Detailed information for compound 1041350

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 356.912 | Formula: C20H21ClN2S
  • H donors: 0 H acceptors: 1 LogP: 4.8 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)C1CN2CCCC2c2c1cccc2C#N.Cl
  • InChi: 1S/C20H20N2S.ClH/c1-23-16-9-7-14(8-10-16)18-13-22-11-3-6-19(22)20-15(12-21)4-2-5-17(18)20;/h2,4-5,7-10,18-19H,3,6,11,13H2,1H3;1H
  • InChiKey: NDROAFPXUAHLBM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Starlite/ChEMBL References
Mus musculus solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 619 aa 578 aa 32.7 %
Plasmodium falciparum transporter, putative solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 617 aa 548 aa 21.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0043 0.0318 1
Echinococcus granulosus peregrin 0.0059 0.0474 0.0464
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0212 0.2018 0.6858
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.009 0.008
Echinococcus granulosus cpg binding protein 0.003 0.0185 0.0176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0539 0.0529
Loa Loa (eye worm) hypothetical protein 0.0059 0.0474 0.0469
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0092 0.0265
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0474 0.0464
Plasmodium vivax thioredoxin reductase, putative 0.0083 0.0725 0.8622
Schistosoma mansoni hypothetical protein 0.0173 0.1628 0.1576
Schistosoma mansoni ap endonuclease 0.0018 0.0069 0.0007
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0023 0.0116 0.0144
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0092 0.0029
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0175 0.1816
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Echinococcus granulosus sodium and chloride dependent glycine 0.0037 0.0258 0.0248
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0029 0.0172 0.0581
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0175 0.0405
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0069
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0029 0.0172 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0092 0.0087
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0074 0.0041
Loa Loa (eye worm) norepinephrine transporter 0.0219 0.2091 0.2087
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0037 0.0258 0.0248
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0092 0.0029
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0069 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0092 0.0029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0539 0.0529
Echinococcus granulosus Aminotransferase class III 0.0043 0.0318 0.0308
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0092 0.0265
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0069 0.0091
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0037 0.0258 0.0248
Trichomonas vaginalis importin beta-1, putative 0.0076 0.0652 0.2046
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.019 0.0421
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.0172 0.0358
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0069
Brugia malayi jmjC domain containing protein 0.0072 0.0614 0.2311
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0043 0.0315 0.1071
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2906
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0092 0.0265
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0074 0.0011
Toxoplasma gondii hypothetical protein 0.0037 0.0258 0.2854
Mycobacterium ulcerans thioesterase TesA 0.0024 0.0124 0.019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Echinococcus multilocularis snurportin 1 0.1003 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0092 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0092 0.0265
Giardia lamblia PHD finger protein 15 0.0059 0.0474 0.7907
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0141
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0037 0.0258 0.0248
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.1819 0.1815
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0043 0.0318 0.085
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0069 0.0024
Brugia malayi hypothetical protein 0.0037 0.0258 0.0917
Loa Loa (eye worm) hypothetical protein 0.0066 0.0548 0.0543
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0175 0.1464
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0019 0.0074 0.0017
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0146 0.0141
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0092 0.0029
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0037 0.0258 0.0197
Schistosoma mansoni ap endonuclease 0.0018 0.0069 0.0007
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0619 0.2329
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0175 0.2063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.1819 0.703
Treponema pallidum NADH oxidase 0.0029 0.0175 0.0522
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0037 0.0258 0.0197
Schistosoma mansoni intermediate filament proteins 0.0026 0.0146 0.0084
Loa Loa (eye worm) hypothetical protein 0.0066 0.0548 0.0543
Schistosoma mansoni sodium/chloride dependent transporter 0.0037 0.0258 0.0197
Loa Loa (eye worm) hypothetical protein 0.0219 0.2091 0.2087
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0029 0.0172 0.0585
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0619 0.056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0614 0.0555
Plasmodium vivax SET domain protein, putative 0.003 0.0181 0.1551
Loa Loa (eye worm) RNA binding protein 0.0073 0.0619 0.0614
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0548 0.0488
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0539 0.0534
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0175 0.0391
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0027 0.0153 0.0521
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0074 0.0064
Loa Loa (eye worm) hypothetical protein 0.0048 0.0369 0.0364
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0069 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Plasmodium falciparum ornithine aminotransferase 0.0043 0.0318 0.3327
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0474 0.0469
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.13 0.4995
Echinococcus multilocularis musashi 0.0026 0.0146 0.0136
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0539 0.0529
Brugia malayi CXXC zinc finger family protein 0.0028 0.0169 0.0568
Mycobacterium leprae Probable polyketide synthase Pks1 0.003 0.019 0.0404
Leishmania major GTP-binding protein, putative 0.0069 0.0581 0.1867
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0174 0.0589
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0043 0.0318 0.1081
Plasmodium falciparum phd finger protein, putative 0.0059 0.0474 0.5352
Brugia malayi jmjC domain containing protein 0.0019 0.0074 0.0195
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0474 0.0414
Echinococcus granulosus importin 5 0.0018 0.0062 0.0052
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0092 0.0082
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0037 0.0258 0.0248
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0092 0.0265
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0092 0.0265
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.0442 0.1502
Brugia malayi Bromodomain containing protein 0.0059 0.0474 0.1761
Plasmodium vivax glutathione reductase, putative 0.0083 0.0725 0.8622
Echinococcus granulosus translational activator gcn1 0.0018 0.0062 0.0052
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.1817 0.1809
Loa Loa (eye worm) solute carrier family 6 member 4 0.0219 0.2091 0.2087
Plasmodium vivax JmjC domain containing protein 0.0019 0.0074 0.0148
Brugia malayi Carboxylesterase family protein 0.0066 0.0548 0.2051
Echinococcus granulosus importin subunit beta 1 0.0094 0.0831 0.0822
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0043 0.0318 0.3602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1819 0.1768
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0614 0.0609
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0074 0.0011
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.2854
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0074 0.0064
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1819 0.1768
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2906
Onchocerca volvulus 0.0026 0.0146 0.0254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1819 0.1811
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0043 0.0318 0.0865
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1282 0.4393
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0206 0.1955 0.7563
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2839 1
Schistosoma mansoni cpg binding protein 0.003 0.0185 0.0124
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0219 0.2091 0.8095
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0037 0.0258 0.0248
Onchocerca volvulus 0.003 0.0181 0.0421
Brugia malayi hypothetical protein 0.0035 0.0234 0.0821
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0069 0.0581 0.1867
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.003 0.019 0.0646
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0092 0.0082
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0029 0.0172 0.0341
Onchocerca volvulus 0.0027 0.0153 0.0288
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Schistosoma mansoni jumonji domain containing protein 0.0152 0.142 0.1366
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0005
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0074 0.0011
Echinococcus granulosus phd:f box containing protein 0.0019 0.0074 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.012
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0069 0.006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Echinococcus granulosus GPCR family 2 0.0065 0.0539 0.0529
Schistosoma mansoni coup transcription factor 0.0021 0.0092 0.0029
Brugia malayi PHD-finger family protein 0.0059 0.0474 0.1761
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0303 0.2942 1
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0614 0.0605
Echinococcus granulosus lamin 0.0026 0.0146 0.0136
Trypanosoma brucei trypanothione reductase 0.0083 0.0725 0.2386
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0539 0.2016
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0037 0.0258 0.0248
Brugia malayi ecdysteroid receptor 0.0021 0.0092 0.0265
Echinococcus granulosus dnaJ subfamily B 0.0404 0.3955 0.395
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0092 0.0082
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0074 0.0069
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0069 0.0064
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0113
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0069 0.0581 0.6879
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0092 0.0082
Schistosoma mansoni cpg binding protein 0.003 0.0185 0.0124
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.0172 0.0358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0092 0.0087
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.003 0.019 0.0404
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0074 0.0555
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0074 0.0069
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0175 0.0381
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0212 0.2018 0.6777
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0092 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0069 0.0119
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0037 0.0258 0.0248
Echinococcus granulosus FTZ F1 alpha 0.043 0.4224 0.4218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0092 0.0087
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0029 0.0172 0.0358
Schistosoma mansoni sodium/chloride dependent transporter 0.0219 0.2091 0.2042
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0069 0.0581 0.0576
Trypanosoma brucei importin beta-1 subunit, putative 0.0094 0.0831 0.2768
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0303 0.2942 1
Brugia malayi Pax transcription factor protein 2 0.0233 0.2231 0.864
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0069 0.0236
Mycobacterium tuberculosis Probable dehydrogenase 0.019 0.1803 0.613
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0175 0.0367
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0092 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1819 0.1811
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0175 0.0367
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0165
Loa Loa (eye worm) carboxylesterase 0.0066 0.0548 0.0543
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.1102 0.1098
Echinococcus granulosus serotonin transporter 0.0219 0.2091 0.2084
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.2854
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0074 0.0069
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0303 0.2942 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0092 0.0029
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0076 0.005
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0028 0.0163 0.0555
Onchocerca volvulus 0.0233 0.2231 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0092 0.0082
Plasmodium falciparum glutathione reductase 0.0083 0.0725 0.8622
Schistosoma mansoni hypothetical protein 0.0065 0.0539 0.0479
Echinococcus multilocularis importin 5 0.0018 0.0062 0.0052
Brugia malayi TAR-binding protein 0.0073 0.0619 0.2329
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.0442 0.0382
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0548 0.0543
Onchocerca volvulus Fatty acid synthase homolog 0.0052 0.0404 0.1462
Schistosoma mansoni hypothetical protein 0.0404 0.3955 0.3918
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0092 0.0082
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0436 0.507
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0442 0.0433
Treponema pallidum sodium- and chloride- dependent transporter 0.0219 0.2091 1
Brugia malayi Pre-SET motif family protein 0.0203 0.1926 0.7448
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0175 0.0405
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0092 0.0087
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0175 0.0405
Trypanosoma brucei importin beta-1 subunit, putative 0.0094 0.0831 0.2768
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0074 0.0148
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0092 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0405
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0181 0.012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0474 0.5544
Brugia malayi jmjC domain containing protein 0.0192 0.1817 0.7021
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0175 0.1464
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0092 0.0087
Plasmodium vivax ornithine aminotransferase, putative 0.0043 0.0318 0.3327
Echinococcus multilocularis Aminotransferase class III 0.0043 0.0318 0.0308
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.003 0.019 0.0646
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0318 0.0308
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0175 0.1464
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0092 0.0029
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.0442 0.1367
Toxoplasma gondii HEAT repeat-containing protein 0.0094 0.0831 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.0253
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.05 0.0441
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.2231 0.2227
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0212 0.2018 0.6858
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.019 0.1803 0.613
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0169 0.0164
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0024 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0619 0.056
Loa Loa (eye worm) kap beta 3 protein 0.0018 0.0062 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1819 0.1768
Mycobacterium ulcerans hypothetical protein 0.0303 0.2942 1
Loa Loa (eye worm) hypothetical protein 0.014 0.13 0.1295
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0442 0.0433
Echinococcus multilocularis transportin 1 0.0018 0.0062 0.0052
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0303 0.2942 1
Schistosoma mansoni cpg binding protein 0.0028 0.0169 0.0107
Plasmodium falciparum glutathione reductase 0.0029 0.0175 0.1464
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0043 0.0315 0.1071
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0092 0.0029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.073 0.0721
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0092 0.0082
Brugia malayi jmjC domain containing protein 0.0019 0.0074 0.0195
Leishmania major importin beta-1 subunit, putative 0.0076 0.0652 0.2122
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0175 0.4242
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0092 0.0265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.012
Brugia malayi glutathione reductase 0.0083 0.0725 0.2745
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0092 0.0265
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0181 0.0172
Entamoeba histolytica Ran family GTPase 0.0069 0.0581 0.8795
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0299 0.0851
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0175 0.0381
Echinococcus multilocularis sodium and chloride dependent glycine 0.0037 0.0258 0.0248
Toxoplasma gondii hypothetical protein 0.0047 0.036 0.4125
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0092 0.0029
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.019 0.1803 0.613
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0092 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0092 0.0087
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0092 0.0082
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0404 0.0399
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Onchocerca volvulus 0.005 0.0386 0.1378
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.2839 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0181 0.0172
Echinococcus multilocularis serotonin transporter 0.0219 0.2091 0.2084
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.0917
Onchocerca volvulus 0.0231 0.2208 0.9892
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.144 0.4895
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0153 0.0506
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0069 0.0091
Schistosoma mansoni hypothetical protein 0.0173 0.1628 0.1576
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0076 0.005
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0069 0.0581 0.6744
Loa Loa (eye worm) acyl carrier protein 0.0013 0.0016 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.1955 0.1951
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0548 0.0538
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0146 0.0478
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Loa Loa (eye worm) importin-beta domain-containing protein 0.0018 0.0062 0.0057
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0175 0.0405
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0069 0.0581 0.0571
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0094 0.0406
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0043 0.0318 0.1081
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0029 0.0172 0.0585
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.7945 0.7943
Schistosoma mansoni hypothetical protein 0.1003 1 1
Schistosoma mansoni hypothetical protein 0.0065 0.0539 0.0479
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0043 0.0318 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1819 0.1811
Leishmania major trypanothione reductase 0.0083 0.0725 0.2386
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0092 0.0265
Schistosoma mansoni hypothetical protein 0.0065 0.0539 0.0479
Brugia malayi nuclear receptor NHR-88 0.0021 0.0092 0.0265
Toxoplasma gondii exonuclease III APE 0.0018 0.0069 0.0501
Loa Loa (eye worm) hypothetical protein 0.0206 0.1955 0.1951
Schistosoma mansoni sodium/chloride dependent transporter 0.0037 0.0258 0.0197
Loa Loa (eye worm) thioredoxin reductase 0.0083 0.0725 0.072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0092 0.0082
Echinococcus granulosus sodium and chloride dependent glycine 0.0037 0.0258 0.0248
Echinococcus multilocularis cpg binding protein 0.003 0.0185 0.0176
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0069 0.0581 0.6744
Loa Loa (eye worm) hypothetical protein 0.0065 0.0539 0.0534
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0442 0.1297
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0074 0.0016
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0474 0.0464
Mycobacterium tuberculosis Probable aminotransferase 0.0303 0.2942 1
Onchocerca volvulus 0.0037 0.0258 0.0778
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0548 0.0538
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0619 0.0614
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0548 0.0538
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0619 0.0614
Brugia malayi Carboxylesterase family protein 0.0066 0.0548 0.2051
Toxoplasma gondii type I fatty acid synthase, putative 0.003 0.019 0.2008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0299 0.0828
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0092 0.0265
Schistosoma mansoni lamin 0.0026 0.0146 0.0084
Loa Loa (eye worm) hypothetical protein 0.01 0.0895 0.0891
Loa Loa (eye worm) hypothetical protein 0.003 0.0181 0.0177
Echinococcus multilocularis geminin 0.0173 0.1628 0.162
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Loa Loa (eye worm) hypothetical protein 0.0219 0.2091 0.2087
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0097 0.0288
Toxoplasma gondii thioredoxin reductase 0.0083 0.0725 0.8679
Brugia malayi PHD-finger family protein 0.0021 0.0092 0.0268
Leishmania major hypothetical protein, conserved 0.0019 0.0074 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1282 0.4378
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0028 0.0163 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0092 0.0265
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0074 0.0016
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0181 0.19
Loa Loa (eye worm) fatty acid synthase 0.0028 0.0168 0.0163
Mycobacterium ulcerans polyketide synthase Pks9 0.0019 0.0074 0.0017
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.0124 0.0173
Mycobacterium tuberculosis Putative ferredoxin reductase 0.019 0.1803 0.613
Echinococcus granulosus ornithine aminotransferase 0.0043 0.0318 0.0308
Onchocerca volvulus Alhambra homolog 0.0059 0.0474 0.1786
Mycobacterium ulcerans thioesterase 0.0024 0.0124 0.019
Mycobacterium tuberculosis Probable reductase 0.019 0.1803 0.613
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.2839 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.1955 0.7563
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.0124 0.0421
Onchocerca volvulus 0.0037 0.0258 0.0778
Echinococcus multilocularis translational activator gcn1 0.0018 0.0062 0.0052
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0614 0.0555
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0175 0.0594
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0023 0.0116 0.0161
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0074 0.0064
Echinococcus granulosus transportin 1 0.0018 0.0062 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.004
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0074 0.0064
Brugia malayi AF-10 protein 0.0019 0.0076 0.0205
Mycobacterium tuberculosis Probable oxidoreductase 0.0212 0.2018 0.6858
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0092 0.0265
Echinococcus granulosus acetylcholinesterase 0.0066 0.0548 0.0538
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0074 0.0011
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0092 0.0029
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.2854
Plasmodium vivax amine transporter, putative 0.0037 0.0258 0.2546
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0598 0.0589
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0021 0.0091 0.0309
Trypanosoma cruzi trypanothione reductase, putative 0.0083 0.0725 0.2367
Onchocerca volvulus 0.0037 0.0258 0.0778
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0234 0.0172
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0299 0.0828
Brugia malayi Thioredoxin reductase 0.0083 0.0725 0.2745
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0069 0.0581 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0158 0.0096
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0069 0.0581 0.218
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0092 0.0082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0092 0.0082
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0076 0.0585
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0037 0.0258 0.5809
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2906
Schistosoma mansoni ran 0.0069 0.0581 0.0521
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0619 0.0609
Echinococcus granulosus intermediate filament protein 0.0026 0.0146 0.0136
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.003 0.019 0.0421
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2906
Schistosoma mansoni sodium-dependent amino acid transporter 0.0037 0.0258 0.0197
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0074 0.0064
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0092 0.0265
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.003 0.019 0.0404
Mycobacterium leprae Polyketide synthase Pks13 0.0043 0.0315 0.084
Brugia malayi jmjC domain containing protein 0.0019 0.0074 0.0195
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0023 0.012 0.0406
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Brugia malayi Importin beta-1 subunit 0.0094 0.0831 0.3159
Echinococcus multilocularis GPCR, family 2 0.0065 0.0539 0.0529
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0442 0.1637
Plasmodium falciparum thioredoxin reductase 0.0083 0.0725 0.8622
Schistosoma mansoni importin beta-1 0.0094 0.0831 0.0773
Onchocerca volvulus 0.0026 0.0146 0.0254
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0619 0.056
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.073 0.0721
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1003 1 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0094 0.0406
Plasmodium falciparum importin beta, putative 0.0094 0.0831 1
Echinococcus multilocularis importin subunit beta 1 0.0094 0.0831 0.0822
Schistosoma mansoni hypothetical protein 0.014 0.13 0.1245
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0175 0.1464
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0037 0.0258 0.0917
Trypanosoma cruzi importin beta-1 subunit, putative 0.0076 0.0652 0.2102
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0069 0.0581 0.1846
Loa Loa (eye worm) hypothetical protein 0.0094 0.0831 0.0826
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0076 0.0652 0.2046
Mycobacterium tuberculosis Polyketide synthase Pks12 0.003 0.019 0.0646
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0069 0.0178
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.0917
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.019 0.1803 0.613
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0023 0.0116 0.0161
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0069 0.006
Brugia malayi Pre-SET motif family protein 0.003 0.0181 0.0617
Echinococcus granulosus lamin dm0 0.0026 0.0146 0.0136
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0019 0.0071 0.0517
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.0172 0.0358
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0299 0.0828
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0175 0.0381
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0234 0.0224
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0092 0.0082
Echinococcus multilocularis sodium and chloride dependent glycine 0.0037 0.0258 0.0248
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0043 0.0318 0.085
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0405
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0074 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.039 0.1156
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.009 0.008
Echinococcus granulosus acetylcholinesterase 0.0066 0.0548 0.0538
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1282 0.4393
Onchocerca volvulus 0.0219 0.2091 0.9349
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0181 0.0172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1819 0.1811
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0318 0.0308
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0092 0.0029
Brugia malayi kap beta 3 protein 0.0018 0.0062 0.0151
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0074 0.0064
Toxoplasma gondii HEAT repeat-containing protein 0.0018 0.0062 0.0413
Echinococcus multilocularis lamin 0.0026 0.0146 0.0136
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0474 0.5352
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0043 0.0318 0.0865
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0083 0.0725 0.2464
Brugia malayi jmjC domain containing protein 0.0019 0.0074 0.0195
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0043 0.0318 0.0865
Mycobacterium ulcerans polyketide synthase 0.003 0.019 0.0421
Loa Loa (eye worm) hypothetical protein 0.0219 0.2091 0.2087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0092 0.0082
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0054 0.0431 0.1594
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0097 0.0288
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.1817 0.1809
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0029 0.0172 0.0585
Mycobacterium ulcerans hypothetical protein 0.0154 0.144 0.4771
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.019 0.1803 0.6029
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1926 0.1922
Plasmodium falciparum thioredoxin reductase 0.0029 0.0175 0.1464
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0043 0.0318 0.0865
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0089 0.0745
Trichomonas vaginalis ran, putative 0.0069 0.0581 0.18
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0442 0.1297
Schistosoma mansoni hypothetical protein 0.0019 0.0076 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0258 0.2546
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0092 0.0265
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0405
Toxoplasma gondii hypothetical protein 0.0037 0.0258 0.2854
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.0917
Brugia malayi nuclear hormone receptor 0.0021 0.0092 0.0265
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0219 0.2091 0.2042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0092 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0619 0.056
Echinococcus granulosus geminin 0.0173 0.1628 0.162
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0175 0.4242
Mycobacterium ulcerans acetylornithine aminotransferase 0.0043 0.0318 0.0865
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0043 0.0318 0.1152
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0367
Schistosoma mansoni hypothetical protein 0.0065 0.0539 0.0479
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0539 0.0529
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0548 0.0538
Schistosoma mansoni hypothetical protein 0.0059 0.0474 0.0414
Loa Loa (eye worm) serotonin transporter b 0.0219 0.2091 0.2087
Mycobacterium ulcerans polyketide synthase 0.0029 0.0172 0.0358
Mycobacterium ulcerans L-lysine aminotransferase 0.0043 0.0318 0.0865
Schistosoma mansoni lamin 0.0026 0.0146 0.0084
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0175 0.1816
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0074 0.0555
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2208 0.745
Brugia malayi RNA binding protein 0.0073 0.0619 0.2329
Loa Loa (eye worm) hypothetical protein 0.0026 0.0141 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0619 0.056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.3955 0.395
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0043 0.0318 0.085
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0405
Plasmodium falciparum transporter, putative 0.0037 0.0258 0.2546
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2839 1
Brugia malayi steroid hormone receptor 0.0021 0.0092 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0092 0.0087
Toxoplasma gondii HEAT repeat-containing protein 0.0018 0.0062 0.0413
Plasmodium vivax importin-beta 2, putative 0.0094 0.0831 1
Plasmodium falciparum amino acid transporter, putative 0.0037 0.0258 0.2546
Schistosoma mansoni ran 0.0069 0.0581 0.0521
Mycobacterium ulcerans polyketide synthase Pks13 0.0043 0.0315 0.0856
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.0047 0.0161
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0074 0.0011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0076 0.0652 0.2046
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0027 0.0153 0.0148
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0474 0.5544
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0539 0.2016
Entamoeba histolytica hypothetical protein 0.0076 0.0652 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0069 0.0581 0.1846
Brugia malayi intermediate filament protein 0.0026 0.0146 0.0478
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0705 0.0696
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0092 0.0082
Echinococcus granulosus tar DNA binding protein 0.0073 0.0619 0.0609
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0043 0.0318 0.0257
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0164 0.0155
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0043 0.0318 0.1081
Echinococcus multilocularis peregrin 0.0059 0.0474 0.0464
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.0253
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0076 0.0585
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0043 0.0318 0.1081
Brugia malayi RNA, U transporter 1 0.0267 0.2578 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.012
Echinococcus granulosus GTP binding nuclear protein Ran 0.0069 0.0581 0.0571
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0069 0.0025
Onchocerca volvulus 0.0028 0.0169 0.0362
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0175 0.0391
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0175 0.0591
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0092 0.0082
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0092 0.0082
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0705 0.0696
Schistosoma mansoni hypothetical protein 0.0035 0.0234 0.0172
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0234 0.0224
Loa Loa (eye worm) glutathione reductase 0.0083 0.0725 0.072
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0146 0.0141
Echinococcus multilocularis lamin dm0 0.0026 0.0146 0.0136

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 5 mg kg-1 Tested in vivo for head twitches antagonizing activity in mice ChEMBL. 2213832
Ki (binding) = 14.7 nM Tested in vitro for serotonin(5-HT) neuronal uptake inhibition ChEMBL. 2213832
Ki (binding) = 390 nM Tested in vitro for norepinephrine(NE) neuronal uptake inhibition ChEMBL. 2213832
Ki (binding) = 2800 nM Tested in vitro for dopamine(DA) neuronal uptake inhibition ChEMBL. 2213832

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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