Detailed information for compound 104330

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.717 | Formula: C30H50O
  • H donors: 0 H acceptors: 0 LogP: 10.89 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=C/C(=C\CC/C(=C/CC/C=C(/CCCC(CCC1OC1C)C)\C)/C)/CCC=C(C)C
  • InChi: 1S/C30H50O/c1-8-29(20-11-14-24(2)3)21-13-19-26(5)16-10-9-15-25(4)17-12-18-27(6)22-23-30-28(7)31-30/h8,14-16,21,27-28,30H,1,9-13,17-20,22-23H2,2-7H3/b25-15+,26-16+,29-21+
  • InChiKey: SQNGRFWURHATRC-GROFMTQQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Lanosterol synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans 2,3-oxidosqualene-lanosterol cyclase Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma cruzi lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania major lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma congolense lanosterol synthase Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania mexicana lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Candida albicans 2,3-oxidosqualene-lanosterol cyclase Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma cruzi lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania donovani lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma brucei lanosterol synthase Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania braziliensis lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
Trypanosoma brucei gambiense lanosterol synthase Get druggable targets OG5_127966 All targets in OG5_127966
Leishmania infantum lanosterol synthase, putative Get druggable targets OG5_127966 All targets in OG5_127966
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major histone deacetylase, putative 0.0032 0.0111 0.0384
Onchocerca volvulus 0.0111 0.0682 0.0672
Echinococcus multilocularis histone deacetylase 7 0.0032 0.0111 0.0221
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0163 0.1054 0.2093
Echinococcus multilocularis tyrosine protein kinase Blk 0.003 0.0091 0.0182
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.008 0.0456 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0089 0.0524 0.2749
Schistosoma mansoni serine/threonine protein kinase 0.0631 0.4433 0.8801
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.017 0.0598
Brugia malayi Variant SH3 domain containing protein 0.0018 0.001 0.0014
Echinococcus granulosus intermediate filament protein 0.0028 0.008 0.0159
Echinococcus granulosus roundabout 2 0.0018 0.0005 0.0011
Mycobacterium leprae Possible carboxypeptidase 0.0534 0.3733 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0054 0.0267 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0109 0.0528
Echinococcus granulosus histone deacetylase 6 0.0032 0.0111 0.0221
Echinococcus granulosus histone deacetylase 7 0.0032 0.0111 0.0221
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0147 0.0292
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0164 0.0326
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0251 0.0347
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0113 0.0389
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0218 0.0712
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0259 0.0869
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0021 0.0032 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0128 0.0628
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0093 0.0313
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0038 0.0151 0.0723
Entamoeba histolytica hypothetical protein 0.0154 0.0987 0.5225
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.008 0.011
Entamoeba histolytica hypothetical protein 0.0037 0.0147 0.0733
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0191 0.1256 0.4687
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0024 0.0054 0.0107
Loa Loa (eye worm) TK protein kinase 0.003 0.0091 0.0426
Trichomonas vaginalis CMGC family protein kinase 0.0277 0.188 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.007 0.0381 0.0756
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0028 0.0082 0.0264
Loa Loa (eye worm) BAR domain-containing protein 0.0018 0.001 0.0024
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0024 0.0054 0.0158
Brugia malayi hypothetical protein 0.0018 0.001 0.0014
Schistosoma mansoni histone deacetylase 1 2 3 0.0032 0.0111 0.0221
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0645 0.4535 0.9002
Echinococcus multilocularis Zinc finger, PHD finger 0.0032 0.0113 0.0224
Echinococcus granulosus histone deacetylase 6 0.0032 0.0111 0.0221
Plasmodium vivax histone deacetylase, putative 0.0032 0.0111 0.0376
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.008 0.0369
Schistosoma mansoni lipoxygenase 0.0122 0.076 0.1509
Echinococcus granulosus poly adp ribose polymerase 2 0.0053 0.0259 0.0514
Loa Loa (eye worm) hypothetical protein 0.0035 0.0133 0.0632
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0054 0.0267 0.0686
Echinococcus granulosus protein kinase C and casein kinase substrate in 0.0018 0.001 0.002
Brugia malayi Angiotensin-converting enzyme family protein 0.0297 0.2023 0.2796
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0034 0.0122 0.0243
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0024 0.0054 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0157 0.0786
Trypanosoma brucei histone deacetylase 1 0.0113 0.0695 0.2602
Echinococcus granulosus poly (ADP ribose) polymerase 0.003 0.0094 0.0186
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0053 0.0259 0.0514
Leishmania major histone deacetylase, putative 0.0113 0.0695 0.2602
Schistosoma mansoni tyrosine kinase 0.0034 0.0122 0.0243
Brugia malayi protein-tyrosine kinase 0.003 0.0091 0.0126
Loa Loa (eye worm) histone deacetylase 11 0.0032 0.0111 0.0525
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0026 0.0051
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0024 0.0054 0.0241
Brugia malayi RNA binding protein 0.0044 0.0193 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0041 0.0176
Loa Loa (eye worm) hypothetical protein 0.0111 0.0682 0.3351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0119 0.058
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0036 0.0137 0.048
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.007 0.0381 0.1337
Echinococcus multilocularis abl interactor 2 0.0018 0.001 0.002
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0021 0.0032 0.0083
Echinococcus multilocularis casein kinase ii subunit alpha 0.0277 0.188 0.3732
Brugia malayi hypothetical protein 0.002 0.0026 0.0035
Loa Loa (eye worm) SRC-1 0.0034 0.0122 0.0579
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0024
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0032 0.0113 0.0156
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.0149 0.0296
Loa Loa (eye worm) hypothetical protein 0.0023 0.0041 0.0176
Brugia malayi hypothetical protein 0.0018 0.001 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0147 0.0292
Trypanosoma cruzi protein farnesyltransferase, putative 0.0024 0.0054 0.0084
Trypanosoma brucei poly(adp-ribose) polymerase 0.0053 0.0259 0.0945
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0179 0.0904
Brugia malayi Telomerase reverse transcriptase 0.1019 0.7235 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0109 0.0528
Schistosoma mansoni microtubule-associated protein tau 0.0714 0.5038 1
Toxoplasma gondii histone deacetylase HDAC1 0.0032 0.0111 0.0376
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0113 0.0309
Plasmodium vivax enoyl-acyl carrier protein reductase 0.008 0.0456 0.1685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0131 0.0647
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0028 0.0082 0.0264
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0022 0.0037 0.0074
Schistosoma mansoni hypothetical protein 0.0037 0.0147 0.0292
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.007 0.0381 0.1983
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0026 0.0051
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0097 0.0576 0.2015
Loa Loa (eye worm) hypothetical protein 0.0073 0.0406 0.1985
Brugia malayi Variant SH3 domain containing protein 0.0018 0.001 0.0014
Trypanosoma brucei telomerase reverse transcriptase 0.0383 0.2643 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.018 0.0643
Giardia lamblia Kinase, CMGC CK2 0.0277 0.188 0.7054
Loa Loa (eye worm) TKL/MLK/MLK protein kinase 0.0022 0.0037 0.0157
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0032 0.0113 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0179 0.0904
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0131 0.0646
Echinococcus granulosus twitchin 0.0018 0.0006 0.0012
Trypanosoma brucei histone deacetylase 2 0.0032 0.0111 0.0384
Echinococcus multilocularis protein of unknown function DUF2013 0.0018 0.001 0.002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0034 0.0122 0.0243
Trypanosoma cruzi histone deacetylase, putative 0.0032 0.0111 0.0304
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0026 0.0051
Brugia malayi sulfakinin receptor protein 0.0139 0.0884 0.1221
Trypanosoma brucei histone deacetylase, putative 0.0032 0.0111 0.0384
Echinococcus multilocularis intersectin 2 0.0023 0.0041 0.0081
Loa Loa (eye worm) hypothetical protein 0.0028 0.008 0.0369
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0098 0.0589 0.2891
Brugia malayi Variant SH3 domain containing protein 0.0018 0.001 0.0014
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0163 0.1054 0.2093
Toxoplasma gondii histone deacetylase HDAC3 0.0113 0.0695 0.2596
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0134 0.0844 0.4459
Entamoeba histolytica protein kinase domain containing protein 0.0277 0.188 1
Echinococcus granulosus histone deacetylase 1 0.0113 0.0695 0.138
Giardia lamblia GTOR 0.0047 0.0218 0.0633
Schistosoma mansoni hypothetical protein 0.0035 0.0133 0.0264
Trichomonas vaginalis CMGC family protein kinase 0.0277 0.188 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0179 0.0904
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0164 0.0326
Brugia malayi Variant SH3 domain containing protein 0.0018 0.001 0.0014
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0122 0.0243
Brugia malayi histone deacetylase 3 (HD3) 0.0113 0.0695 0.0961
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0267 0.097
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0041 0.0164
Trichomonas vaginalis CMGC family protein kinase 0.0277 0.188 1
Giardia lamblia Telomerase catalytic subunit 0.0383 0.2643 1
Schistosoma mansoni polycystin 1-related 0.002 0.0026 0.0051
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0024 0.0054 0.0107
Echinococcus multilocularis histone deacetylase 3 0.0113 0.0695 0.138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0131 0.0646
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0093 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0179 0.0904
Schistosoma mansoni growth factor receptor-bound protein 0.0027 0.0073 0.0144
Echinococcus granulosus poly ADP ribose polymerase 1 0.0096 0.0571 0.1134
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0589 0.1169
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0026 0.0051
Schistosoma mansoni rab6-interacting 0.002 0.0026 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0277 0.188 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0024 0.0054 0.0234
Echinococcus granulosus protein of unknown function DUF2013 0.0018 0.001 0.002
Schistosoma mansoni histone deacetylase 4 5 0.0032 0.0111 0.0221
Echinococcus multilocularis tyrosine protein kinase HCK 0.0025 0.006 0.0119
Loa Loa (eye worm) hypothetical protein 0.0064 0.0341 0.1664
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0024 0.0054 0.0241
Plasmodium vivax histone deacetylase 2, putative 0.0032 0.0111 0.0376
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0032 0.0113 0.0224
Brugia malayi Abl-interactor 1 0.0018 0.001 0.0014
Trypanosoma cruzi histone deacetylase 1, putative 0.0113 0.0695 0.254
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.0699
Echinococcus multilocularis histone deacetylase 6 0.0032 0.0111 0.0221
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0028 0.0082 0.0272
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.1711 0.8451
Echinococcus granulosus tyrosine protein kinase Src64B 0.0034 0.0122 0.0243
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0041 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0131 0.0647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0131 0.0647
Loa Loa (eye worm) histone deacetylase 0.0032 0.0111 0.0525
Schistosoma mansoni lamin 0.0028 0.008 0.0159
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0046 0.0214 0.0767
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0093 0.0441
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0024 0.0054 0.0107
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0036 0.0137 0.0401
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0053 0.0259 0.0514
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.007 0.0381 0.1409
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0113 0.0309
Schistosoma mansoni peptidase Clp (S14 family) 0.0054 0.0267 0.0531
Echinococcus granulosus rho guanine nucleotide exchange factor 16 0.0018 0.001 0.002
Giardia lamblia Phosphatidylinositol 4-kinase 0.0028 0.0082 0.0107
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0093 0.0432
Toxoplasma gondii FATC domain-containing protein 0.0021 0.0032 0.0075
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0051 0.0249 0.0752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0019 0.0046
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0024 0.0054 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0131 0.0646
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0218 0.1111
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0024 0.0054 0.0107
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0024 0.0054 0.0234
Echinococcus granulosus histone deacetylase 0.0032 0.0111 0.0221
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.008 0.0456 0.1191
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0024 0.0054 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.017 0.0852
Brugia malayi WGR domain containing protein 0.0096 0.0571 0.079
Schistosoma mansoni amine GPCR 0.0403 0.2786 0.553
Trypanosoma cruzi histone deacetylase 1, putative 0.0113 0.0695 0.254
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0024 0.0054 0.0075
Brugia malayi SRC-1 0.0034 0.0122 0.0169
Brugia malayi Protein kinase domain containing protein 0.0098 0.0589 0.0814
Trypanosoma brucei wee1-like protein kinase 0.0036 0.0137 0.048
Loa Loa (eye worm) abl-interactor 1 0.0018 0.001 0.0024
Entamoeba histolytica casein kinase, putative 0.0277 0.188 1
Onchocerca volvulus 0.0111 0.0682 0.0672
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0291 0.1979 0.3929
Trypanosoma cruzi histone deacetylase, putative 0.0032 0.0111 0.0304
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0032 0.0113 0.0381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0179 0.0904
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0028 0.0082 0.019
Plasmodium falciparum enoyl-acyl carrier reductase 0.008 0.0456 0.1685
Schistosoma mansoni hematopoietic lineage cell specific protein 0.0018 0.001 0.002
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0091 0.0182
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0093 0.0313
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0018 0.001 0.002
Echinococcus multilocularis roundabout 2 0.0018 0.0005 0.0011
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0028 0.008 0.0263
Leishmania major histone deacetylase, putative 0.0032 0.0111 0.0384
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0093 0.0184
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0024
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0154 0.0987 0.5225
Plasmodium vivax histone deacetylase, putative 0.0032 0.0111 0.0376
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0024 0.0054 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.017 0.0852
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.008 0.0456 0.0543
Schistosoma mansoni tyrosine kinase 0.0034 0.0122 0.0243
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0218 0.0712
Brugia malayi Variant SH3 domain containing protein 0.0018 0.001 0.0014
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0024 0.0054 0.0166
Echinococcus multilocularis microtubule associated protein 2 0.0714 0.5038 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0057 0.0179
Trypanosoma brucei Casein kinase II 0.0277 0.188 0.7103
Schistosoma mansoni protein kinase 0.0277 0.188 0.3732
Trichomonas vaginalis histone deacetylase, putative 0.0113 0.0695 0.3664
Echinococcus multilocularis RIMS binding protein 2 0.0018 0.001 0.002
Plasmodium falciparum histone deacetylase, putative 0.0032 0.0111 0.0376
Echinococcus multilocularis lamin dm0 0.0028 0.008 0.0159
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0113 0.0695 0.3664
Toxoplasma gondii histone deacetylase HDAC5 0.0032 0.0111 0.0376
Trichomonas vaginalis histone deacetylase, putative 0.0113 0.0695 0.3664
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0122 0.0243
Trichomonas vaginalis CMGC family protein kinase 0.0277 0.188 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0032 0.0044
Brugia malayi Variant SH3 domain containing protein 0.0018 0.001 0.0014
Echinococcus multilocularis serine protein kinase ATM 0.0021 0.0032 0.0064
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0218 0.0789
Onchocerca volvulus 0.0023 0.0041 0.0031
Leishmania major hypothetical protein, conserved 0.0067 0.0361 0.1333
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.01 0.0602 0.0832
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0037 0.0051
Schistosoma mansoni histone deacetylase 0.0113 0.0695 0.138
Onchocerca volvulus Histone deacetylase 10 homolog 0.0032 0.0111 0.0101
Entamoeba histolytica protein kinase rad3, putative 0.0021 0.0032 0.0117
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0024 0.0054 0.0234
Schistosoma mansoni histone deacetylase hda2 0.0032 0.0111 0.0221
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0054 0.0267 0.0531
Echinococcus multilocularis histone deacetylase 0.0032 0.0111 0.0221
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0093 0.0184
Schistosoma mansoni membrane traffic protein 0.0018 0.001 0.002
Echinococcus granulosus intersectin 2 0.0023 0.0041 0.0081
Schistosoma mansoni fkbp-rapamycin associated protein 0.0021 0.0032 0.0064
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.001 0.0024
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0032 0.0113 0.0381
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0147 0.0292
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0034 0.0122 0.0243
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0032 0.0113 0.0531
Schistosoma mansoni hypothetical protein 0.0018 0.001 0.002
Schistosoma mansoni sh3-containing grb2-like protein 3 (endophilin III) 0.0018 0.001 0.002
Loa Loa (eye worm) phosphatidylinositol 3 0.0028 0.0082 0.0378
Leishmania major geranylgeranyltransferase, putative 0.0024 0.0054 0.0166
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0024
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0093 0.0232
Schistosoma mansoni histone deacetylase 0.0113 0.0695 0.138
Leishmania major hypothetical protein, conserved 0.0023 0.0041 0.0117
Trypanosoma cruzi protein farnesyltransferase, putative 0.0024 0.0054 0.0084
Echinococcus granulosus serine protein kinase ATM 0.0021 0.0032 0.0064
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0032 0.0113 0.0548
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0241
Brugia malayi histone deacetylase 11 0.0032 0.0111 0.0154
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0032 0.0113 0.0381
Echinococcus granulosus LIM and SH3 domain protein 1 0.0018 0.001 0.002
Toxoplasma gondii RNA-directed DNA polymerase 0.0383 0.2643 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0024
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0054 0.0267 0.097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0218 0.1111
Echinococcus multilocularis Src y 3 domain 0.0018 0.001 0.002
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0218 0.0433
Toxoplasma gondii histone deacetylase HDAC4 0.0032 0.0111 0.0376
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0133 0.0184
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0018 0.001 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0041 0.0034
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.001 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.017 0.0852
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0053 0.0259 0.087
Echinococcus multilocularis Cbl interacting protein of 85 kDa 0.0018 0.001 0.002
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0113 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.017 0.0852
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0036 0.0137 0.0401
Schistosoma mansoni rab6-interacting 0.002 0.0026 0.0051
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0291 0.1979 0.3929
Trypanosoma brucei lanosterol synthase 0.0178 0.1162 0.4376
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0381 0.0527
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0053 0.0259 0.087
Brugia malayi Doublecortin family protein 0.002 0.0026 0.0035
Onchocerca volvulus 0.002 0.0026 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0109 0.0528
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0113 0.0695 0.3664
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.008 0.0456 0.0895
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0034 0.0122 0.0243
Brugia malayi Variant SH3 domain containing protein 0.0018 0.001 0.0014
Trypanosoma cruzi lanosterol synthase, putative 0.0178 0.1162 0.4329
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0021 0.0032 0.0117
Mycobacterium tuberculosis Conserved protein 0.0534 0.3733 1
Echinococcus granulosus abl interactor 2 0.0018 0.001 0.002
Brugia malayi hypothetical protein 0.0037 0.0147 0.0203
Echinococcus multilocularis protein kinase C and casein kinase substrate in 0.0018 0.001 0.002
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0093 0.0313
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.008 0.0456 0.1685
Loa Loa (eye worm) histone deacetylase 7A 0.0032 0.0111 0.0525
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0044 0.0193 0.0932
Plasmodium falciparum telomerase reverse transcriptase 0.0383 0.2643 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0025 0.006 0.0119
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0218 0.1111
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.017 0.0852
Loa Loa (eye worm) histone deacetylase 1 0.0113 0.0695 0.3419
Loa Loa (eye worm) hypothetical protein 0.0127 0.0793 0.3901
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0024
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0267 1
Echinococcus multilocularis tar DNA binding protein 0.0044 0.0193 0.0384
Brugia malayi Variant SH3 domain containing protein 0.0018 0.001 0.0014
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.001 0.0024
Schistosoma mansoni histone deacetylase 4 5 0.0032 0.0111 0.0221
Entamoeba histolytica histone deacetylase, putative 0.0113 0.0695 0.3664
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0188 0.1238 0.6107
Trypanosoma cruzi histone deacetylase, putative 0.0032 0.0111 0.0304
Schistosoma mansoni hypothetical protein 0.0018 0.001 0.002
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0024 0.0054 0.0158
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0024 0.0054 0.0107
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0024 0.0054 0.0234
Leishmania major histone deacetylase, putative 0.0113 0.0695 0.2602
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0026 0.0051
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0191 0.1256 0.666
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0383 0.2643 1
Trichomonas vaginalis histone deacetylase, putative 0.0113 0.0695 0.3664
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0193 0.0384
Plasmodium falciparum histone deacetylase 1 0.0113 0.0695 0.2596
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.017 0.0852
Loa Loa (eye worm) hypothetical protein 0.0139 0.0884 0.4353
Schistosoma mansoni histone deacetylase hda2 0.0032 0.0111 0.0221
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0032 0.0113 0.0548
Entamoeba histolytica hypothetical protein 0.0037 0.0147 0.0733
Loa Loa (eye worm) intermediate filament protein 0.0028 0.008 0.0369
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0024 0.0054 0.0234
Brugia malayi hypothetical protein 0.002 0.0026 0.0035
Schistosoma mansoni lipoxygenase 0.0085 0.0495 0.0982
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0127 0.0793 0.1573
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0026 0.0051
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0055 0.0279 0.0946
Echinococcus granulosus RUN 0.002 0.0026 0.0051
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0383 0.2643 1
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0096 0.0571 0.1134
Onchocerca volvulus 0.0165 0.1072 0.1062
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.003 0.0091 0.0182
Echinococcus granulosus tar DNA binding protein 0.0044 0.0193 0.0384
Leishmania major casein kinase II, putative 0.0277 0.188 0.7103
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0122 0.0243
Schistosoma mansoni hypothetical protein 0.002 0.0026 0.0051
Mycobacterium ulcerans D-alanyl-D-alanine carboxypeptidase 0.0534 0.3733 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0241
Leishmania major phosphatidylinositol 4-kinase, putative 0.0028 0.0082 0.0272
Trichomonas vaginalis histone deacetylase, putative 0.0113 0.0695 0.3664
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0054 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0191 0.1256 0.1735
Loa Loa (eye worm) hypothetical protein 0.0053 0.0259 0.1257
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0177 0.1154 0.6114
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0035 0.0133 0.0325
Trichomonas vaginalis histone deacetylase, putative 0.0113 0.0695 0.3664
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0193 0.0384
Entamoeba histolytica hypothetical protein 0.0021 0.0032 0.0117
Echinococcus granulosus histone deacetylase 3 0.0113 0.0695 0.138
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0024 0.0054 0.0234
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0251 0.0347
Echinococcus multilocularis LIM and SH3 domain protein 1 0.0018 0.001 0.002
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0127 0.0793 0.1573
Echinococcus multilocularis histone deacetylase 1 0.0113 0.0695 0.138
Echinococcus multilocularis lamin 0.0028 0.008 0.0159
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0024 0.0054 0.0107
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0032 0.0044
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.007 0.0381 0.1983
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0096 0.0571 0.1134
Echinococcus granulosus lamin dm0 0.0028 0.008 0.0159
Schistosoma mansoni hypothetical protein 0.0018 0.001 0.002
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0122 0.0243
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0122 0.0243
Brugia malayi Probable ClpP-like protease 0.0054 0.0267 0.037
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0023 0.0041 0.0109
Echinococcus granulosus tyrosine kinase 0.003 0.0091 0.0182
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0024 0.0054 0.0158
Echinococcus granulosus growth factor receptor bound protein 2 0.0027 0.0073 0.0144
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.007 0.0381 0.1983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0218 0.1111
Plasmodium vivax histone deacetylase 1, putative 0.0113 0.0695 0.2596
Echinococcus granulosus Cbl interacting protein of 85 kDa 0.0018 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0188 0.1238 0.1711
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0024 0.0054 0.0166
Brugia malayi intermediate filament protein 0.0028 0.008 0.011
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0032 0.0113 0.0548
Loa Loa (eye worm) TAR-binding protein 0.0044 0.0193 0.0932
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0024 0.0054 0.0107
Echinococcus multilocularis histone deacetylase 6 0.0032 0.0111 0.0221
Loa Loa (eye worm) hypothetical protein 0.0052 0.0251 0.1217
Trichomonas vaginalis CMGC family protein kinase 0.0277 0.188 1
Onchocerca volvulus 0.002 0.0026 0.0015
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0036 0.0137 0.048
Brugia malayi histone deacetylase 1 (HD1) 0.0113 0.0695 0.0961
Entamoeba histolytica hypothetical protein 0.0037 0.0147 0.0733
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0032 0.0113 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.017 0.0852
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.076 0.1509
Echinococcus multilocularis histone deacetylase 6 0.0032 0.0111 0.0221
Loa Loa (eye worm) hypothetical protein 0.0104 0.0626 0.3076
Schistosoma mansoni nebulin 0.0018 0.001 0.002
Loa Loa (eye worm) TK protein kinase 0.0025 0.006 0.027
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.018 0.0565
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0093 0.0232
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0034 0.0122 0.0243
Loa Loa (eye worm) RNA binding protein 0.0044 0.0193 0.0932
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0127 0.0793 0.1096
Trichomonas vaginalis CMGC family protein kinase 0.0277 0.188 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.001 0.0024
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0191 0.1256 0.666
Trichomonas vaginalis histone deacetylase, putative 0.0113 0.0695 0.3664
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0046 0.0208 0.0412
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0024 0.0054 0.0234
Schistosoma mansoni tyrosine kinase 0.0031 0.0101 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0032 0.0117
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0113 0.0389
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0054 0.0267 0.097
Echinococcus multilocularis rho guanine nucleotide exchange factor 16 0.0018 0.001 0.002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0191 0.1256 0.666
Schistosoma mansoni loxhd1 0.002 0.0026 0.0051
Leishmania major lanosterol synthase, putative 0.0153 0.0987 0.3708
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0024 0.0054 0.0158
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0028 0.0082 0.019
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0218 0.0789
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0277 0.188 0.9291
Loa Loa (eye worm) hypothetical protein 0.0111 0.0682 0.3351
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0251 0.1217
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0132
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0034 0.0122 0.0243
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0026 0.0051
Trypanosoma brucei histone deacetylase 3 0.0032 0.0111 0.0384
Loa Loa (eye worm) doublecortin family protein 0.002 0.0026 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0141 0.0699
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0093 0.0441
Echinococcus granulosus microtubule associated protein 2 0.0714 0.5038 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0093 0.0313
Echinococcus multilocularis RUN 0.002 0.0026 0.0051
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0032 0.0113 0.0224
Echinococcus granulosus lamin 0.0028 0.008 0.0159
Loa Loa (eye worm) histone deacetylase 3 0.0113 0.0695 0.3419
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0218 0.0789
Echinococcus multilocularis NCK adaptor protein 0.0027 0.0073 0.0144
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0028 0.0082 0.0162
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0134 0.0844 0.4459
Toxoplasma gondii histone deacetylase HDAC2 0.0113 0.0695 0.2596
Echinococcus multilocularis tyrosine protein kinase Srms 0.003 0.0091 0.0182
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0032 0.0113 0.0548
Plasmodium falciparum histone deacetylase 2 0.0032 0.0111 0.0376
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0277 0.188 0.7101
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.008 0.0456 1
Echinococcus granulosus sh3 containing grb2 protein 3 0.0018 0.001 0.002
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0032 0.0113 0.0224
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0054 0.0084
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0034 0.0122 0.0243
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0218 0.0433
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0026 0.0051
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0218 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0032 0.0117
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0034 0.0122 0.0243
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0111 0.0682 0.1353
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0218 0.1053
Schistosoma mansoni dynamin-associated protein 0.0023 0.0041 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0032 0.0117
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0024 0.0054 0.0075
Entamoeba histolytica protein kinase, putative 0.0025 0.006 0.0266
Echinococcus multilocularis sh3 containing grb2 protein 3 0.0018 0.001 0.002
Echinococcus granulosus WGR domain containing protein 0.003 0.0094 0.0186
Brugia malayi WGR domain containing protein 0.0053 0.0259 0.0358
Trypanosoma cruzi histone deacetylase, putative 0.0032 0.0111 0.0304
Plasmodium vivax telomerase reverse transcriptase, putative 0.0383 0.2643 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.076 0.1509
Brugia malayi Cation transporter family protein 0.0111 0.0682 0.0942
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0093 0.0128
Onchocerca volvulus 0.0028 0.008 0.007
Toxoplasma gondii CMGC kinase, CK2 family 0.0277 0.188 0.7101
Schistosoma mansoni hypothetical protein 0.0018 0.001 0.002
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0191 0.1256 0.4687
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0093 0.0441
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0082 0.0113
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0032 0.0113 0.0548
Echinococcus multilocularis 0.0028 0.0082 0.0162
Brugia malayi Histone deacetylase family protein 0.0032 0.0111 0.0154
Echinococcus granulosus peptidase Clp S14 family 0.0035 0.0133 0.0265
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.007 0.0381 0.1983
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0024 0.0054 0.0084
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0093 0.0184
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.007 0.0381 0.1983
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0113 0.0695 0.3664
Echinococcus granulosus Src y 3 domain 0.0018 0.001 0.002
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0193 0.0384
Onchocerca volvulus 0.0028 0.008 0.007
Leishmania major telomerase reverse transcriptase, putative 0.0383 0.2643 1
Brugia malayi RNA recognition motif domain containing protein 0.0044 0.0193 0.0267
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.01 0.0599 0.2229
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0291 0.1979 0.3929
Plasmodium vivax geranylgeranyltransferase, putative 0.0024 0.0054 0.0158
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0193 0.0384
Echinococcus multilocularis peptidase Clp (S14 family) 0.0035 0.0133 0.0265
Trichomonas vaginalis hypothetical protein 0.008 0.0456 0.2381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.035
Trypanosoma cruzi histone deacetylase, putative 0.0032 0.0111 0.0304
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0024
Echinococcus multilocularis endophilin A3 0.0018 0.001 0.002
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0645 0.4535 0.9002
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0034 0.0122 0.0243
Trypanosoma cruzi casein kinase II, putative 0.0277 0.188 0.7079
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0111 0.0682 0.1353
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0218 0.0789
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0297 0.2023 1
Echinococcus granulosus histone deacetylase 8 0.0032 0.0111 0.0221
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0024 0.0054 0.0234
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0024 0.0054 0.0107
Onchocerca volvulus Tyrosine kinase homolog 0.0176 0.1151 0.1142
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0218 0.0301
Loa Loa (eye worm) hypothetical protein 0.0113 0.0695 0.3419
Echinococcus granulosus histone deacetylase 6 0.0032 0.0111 0.0221
Trypanosoma brucei histone deacetylase 4 0.0032 0.0111 0.0384
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0021 0.0032 0.0064
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0024 0.0054 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0131 0.0647
Giardia lamblia Histone deacetylase 0.0113 0.0695 0.2477
Plasmodium falciparum geranylgeranyltransferase, putative 0.0024 0.0054 0.0158
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0279 0.1355
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0267 0.097
Echinococcus granulosus RIMS binding protein 2 0.0018 0.001 0.002
Plasmodium vivax unspecified product 0.0277 0.188 0.7101
Brugia malayi Variant SH3 domain containing protein 0.0018 0.001 0.0014
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0122 0.0243
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0024 0.0054 0.0158
Loa Loa (eye worm) hypothetical protein 0.0032 0.0111 0.0525
Brugia malayi TAR-binding protein 0.0044 0.0193 0.0267
Leishmania major farnesyltransferase beta subunit 0.0024 0.0054 0.0166
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0098 0.0589 0.1266
Echinococcus granulosus casein kinase ii subunit alpha 0.0277 0.188 0.3732
Plasmodium falciparum casein kinase 2, alpha subunit 0.0277 0.188 0.7101
Schistosoma mansoni lamin 0.0028 0.008 0.0159
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0028 0.0082 0.0162
Entamoeba histolytica hypothetical protein 0.0037 0.0147 0.0733
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0193 0.0384
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0096 0.0571 0.3001
Loa Loa (eye worm) hypothetical protein 0.0054 0.0267 0.1298
Schistosoma mansoni intermediate filament proteins 0.0028 0.008 0.0159
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0042 0.018 0.0643
Onchocerca volvulus 0.0111 0.0682 0.0672
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0191 0.1256 0.666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0218 0.1111
Echinococcus granulosus tyrosine protein kinase Blk 0.003 0.0091 0.0182
Brugia malayi Histone deacetylase family protein 0.0032 0.0111 0.0154
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0036 0.0137 0.0401
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0021 0.0032 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0093 0.0441
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0024 0.0054 0.0158
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0041 0.0057
Brugia malayi Histone deacetylase 1 0.0113 0.0695 0.0961
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0024 0.0054 0.0234
Brugia malayi Casein kinase II, alpha chain 0.0277 0.188 0.2599
Brugia malayi hypothetical protein 0.0139 0.0884 0.1221
Echinococcus multilocularis histone deacetylase 8 0.0032 0.0111 0.0221
Trypanosoma cruzi lanosterol synthase, putative 0.0178 0.1162 0.4329
Echinococcus multilocularis musashi 0.0028 0.008 0.0159
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0024 0.0054 0.0107

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.3 uM Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from rat liver ChEMBL. 9003518
IC50 (binding) = 0.3 uM Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from rat liver ChEMBL. 9003518
IC50 (binding) = 0.5 uM Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from pig liver ChEMBL. 9003518
IC50 (binding) = 0.5 uM Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from pig liver ChEMBL. 9003518
Ki (binding) = 2.5 uM Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from rat liver ChEMBL. 9003518
Ki (binding) = 2.5 uM Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from rat liver ChEMBL. 9003518
Ki (binding) = 4.4 uM Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from pig liver ChEMBL. 9003518
Ki (binding) = 4.4 uM Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from pig liver ChEMBL. 9003518
kinact (binding) = 221 min-1 Compound was tested for rate of inactivation on Oxidosqualene-lanosterol cyclase on pig liver ChEMBL. 9003518
kinact (binding) = 221 min-1 Compound was tested for rate of inactivation on Oxidosqualene-lanosterol cyclase on pig liver ChEMBL. 9003518

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.