Detailed information for compound 1054643

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 309.818 | Formula: C13H16ClN5S
  • H donors: 2 H acceptors: 2 LogP: 2.57 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1c1nnc(s1)NC1=NCCCN1.Cl
  • InChi: 1S/C13H15N5S.ClH/c1-9-5-2-3-6-10(9)11-17-18-13(19-11)16-12-14-7-4-8-15-12;/h2-3,5-6H,4,7-8H2,1H3,(H2,14,15,16,18);1H
  • InChiKey: LQGKEBXDCHWQCG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0043 0.0061
Schistosoma mansoni septate junction protein 0.0034 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0251 0.0784 0.1113
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0017
Echinococcus granulosus Tolloid protein 1 0.0067 0.0134 0.0134
Plasmodium falciparum cysteine repeat modular protein 1 0.0544 0.182 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0036 0.0036
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0069 0.0093
Toxoplasma gondii PAN domain-containing protein 0.0099 0.0246 0.0461
Loa Loa (eye worm) hypothetical protein 0.0138 0.0382 0.0543
Loa Loa (eye worm) hypothetical protein 0.0099 0.0246 0.0349
Loa Loa (eye worm) hypothetical protein 0.0145 0.0408 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0044 0.0062
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0012 0.0012
Onchocerca volvulus 0.1772 0.6157 0.8739
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0062
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0544 0.182 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0067 0.0133 0.0188
Onchocerca volvulus 0.0034 0.0017 0.0019
Brugia malayi PAN domain containing protein 0.0099 0.0246 0.0349
Brugia malayi Cadherin domain containing protein 0.0034 0.0017 0.0024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0099 0.0246 0.0349
Loa Loa (eye worm) TK/ROR protein kinase 0.0544 0.182 0.2584
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0099 0.0246 0.0461
Echinococcus multilocularis lamin dm0 0.003 0.0003 0.0003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0044 0.0044
Echinococcus multilocularis enteropeptidase 0.0251 0.0784 0.0784
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0044 0.0044
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.0017 0.0017
Toxoplasma gondii subtilisin SUB12 0.0099 0.0246 0.0461
Schistosoma mansoni coup transcription factor 0.0042 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0065 0.0125 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0044 0.0062
Toxoplasma gondii microneme protein, putative 0.0099 0.0246 0.0461
Onchocerca volvulus Neurogenic locus notch homolog 0.0034 0.0017 0.0019
Echinococcus multilocularis expressed protein 0.0049 0.0069 0.0069
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0049 0.0069 0.0098
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Brugia malayi mbt repeat family protein 0.0049 0.0069 0.0098
Echinococcus granulosus GPCR family 2 0.0064 0.0121 0.0121
Echinococcus multilocularis neurogenic locus notch protein 4 0.0034 0.0017 0.0017
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0044 0.0058
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0069 0.0069
Echinococcus multilocularis microtubule associated protein 2 0.2859 1 1
Onchocerca volvulus 0.0099 0.0246 0.0344
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0055 0.0091 0.0129
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0036 0.0036
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0251 0.0784 0.0784
Brugia malayi Bromodomain containing protein 0.0033 0.0012 0.0017
Toxoplasma gondii hypothetical protein 0.0099 0.0246 0.0461
Toxoplasma gondii hypothetical protein 0.0099 0.0246 0.0461
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.0608 0.0862
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0069 0.0379
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0078 0.0172 0.0218
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0251 0.0784 0.0784
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0078 0.0172 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0175 0.0249
Schistosoma mansoni cercarial elastase (S01 family) 0.0251 0.0784 0.0784
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0034 0.0017 0.0019
Brugia malayi nuclear receptor NHR-88 0.0042 0.0044 0.0062
Onchocerca volvulus 0.0099 0.0246 0.0344
Onchocerca volvulus 0.0049 0.0069 0.0093
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Schistosoma mansoni slit 0.0034 0.0017 0.0017
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0197 0.0594 0.0594
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0062
Loa Loa (eye worm) hypothetical protein 0.0251 0.0784 0.1113
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0044 0.0062
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0017
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.0017 0.0017
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0057 0.0057
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.0017 0.0017
Echinococcus granulosus slit 2 protein 0.0034 0.0017 0.0017
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0078 0.0172 0.5
Loa Loa (eye worm) PAN domain-containing protein 0.0099 0.0246 0.0349
Loa Loa (eye worm) hypothetical protein 0.2023 0.7045 1
Onchocerca volvulus 0.0251 0.0784 0.1109
Loa Loa (eye worm) hypothetical protein 0.0099 0.0246 0.0349
Brugia malayi jmjC domain containing protein 0.004 0.0036 0.0051
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0043 0.0235
Schistosoma mansoni notch 0.0034 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0099 0.0246 0.0349
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0017
Onchocerca volvulus 0.0034 0.0017 0.0019
Entamoeba histolytica hypothetical protein 0.0074 0.0156 0.5724
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0069 0.0069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.0608 0.0862
Brugia malayi nuclear hormone receptor 0.0042 0.0044 0.0062
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0044 0.0044
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0251 0.0784 0.0784
Brugia malayi mbt repeat family protein 0.0049 0.0069 0.0098
Echinococcus multilocularis snurportin 1 0.0315 0.1007 0.1007
Echinococcus granulosus notch 0.0034 0.0017 0.0017
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.075 0.075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0044 0.0062
Onchocerca volvulus Alhambra homolog 0.0033 0.0012 0.0012
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0078 0.0172 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.0061
Echinococcus multilocularis protein jagged 1 0.0034 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0065 0.0125 0.0177
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0116 0.0218
Brugia malayi Trypsin-like protease protein 5 0.0251 0.0784 0.1113
Brugia malayi hypothetical protein 0.0251 0.0784 0.1113
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0044 0.0044
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0093 0.0132
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0197 0.0594 0.0594
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.075 0.075
Onchocerca volvulus 0.0099 0.0246 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0044 0.0062
Echinococcus granulosus transmembrane protease serine 3 0.0251 0.0784 0.0784
Entamoeba histolytica hypothetical protein 0.0074 0.0156 0.5724
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.0594 0.0843
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0003 0.0004
Onchocerca volvulus 0.0453 0.1495 0.2119
Echinococcus granulosus snurportin 1 0.0315 0.1007 0.1007
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0327 0.0464
Loa Loa (eye worm) RNA binding protein 0.0197 0.0594 0.0843
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0034 0.0017 0.0017
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0093 0.0093
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0078 0.0172 0.0244
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0121 0.0121
Echinococcus multilocularis protein jagged 1 0.0034 0.0017 0.0017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0382 0.1247 0.177
Onchocerca volvulus Huntingtin homolog 0.0382 0.1247 0.1767
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0135 0.0135
Schistosoma mansoni notch 0.0034 0.0017 0.0017
Toxoplasma gondii PAN domain-containing protein 0.1537 0.5329 1
Brugia malayi EGF-like domain containing protein 0.0034 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0001 0.0002
Echinococcus granulosus tar DNA binding protein 0.0197 0.0594 0.0594
Brugia malayi RNA, U transporter 1 0.0084 0.0192 0.0273
Onchocerca volvulus 0.0251 0.0784 0.1109
Schistosoma mansoni hypothetical protein 0.0049 0.007 0.007
Schistosoma mansoni cercarial elastase (S01 family) 0.0251 0.0784 0.0784
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0043 0.0043
Brugia malayi Trypsin family protein 0.0251 0.0784 0.1113
Echinococcus granulosus peregrin 0.0033 0.0012 0.0012
Schistosoma mansoni cercarial elastase (S01 family) 0.0251 0.0784 0.0784
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0036 0.0051
Brugia malayi hypothetical protein 0.0038 0.0029 0.0041
Onchocerca volvulus 0.0065 0.0125 0.0173
Entamoeba histolytica hypothetical protein 0.0074 0.0156 0.5724
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0044 0.0062
Loa Loa (eye worm) MBCTL1 0.0056 0.0093 0.0132
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0078 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Toxoplasma gondii microneme protein MIC4 0.0099 0.0246 0.0461
Loa Loa (eye worm) hypothetical protein 0.0453 0.1495 0.2123
Plasmodium falciparum phd finger protein, putative 0.0033 0.0012 0.0065
Onchocerca volvulus 0.0099 0.0246 0.0344
Onchocerca volvulus 0.0099 0.0246 0.0344
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0017 0.0024
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0044 0.0044
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0197 0.0197
Onchocerca volvulus Huntingtin homolog 0.0382 0.1247 0.1767
Loa Loa (eye worm) hypothetical protein 0.0056 0.0095 0.0134
Brugia malayi hypothetical protein 0.0074 0.0156 0.0222
Onchocerca volvulus 0.0034 0.0017 0.0019
Echinococcus multilocularis notch 0.0034 0.0017 0.0017
Toxoplasma gondii PAN domain-containing protein 0.0099 0.0246 0.0461
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0116 0.5
Onchocerca volvulus Putative cubilin 0.0046 0.0059 0.008
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0034 0.0034
Brugia malayi hypothetical protein 0.0242 0.075 0.1064
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0044 0.0044
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0044 0.0058
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0044 0.0044
Echinococcus multilocularis muscleblind protein 0.0145 0.0408 0.0408
Schistosoma mansoni cell polarity protein 0.0034 0.0017 0.0017
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0078 0.0172 0.0945
Trypanosoma cruzi hypothetical protein, conserved 0.0544 0.182 1
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.0017 0.0017
Brugia malayi Calcium binding EGF domain containing protein 0.0046 0.0059 0.0084
Toxoplasma gondii PAN domain-containing protein 0.0099 0.0246 0.0461
Brugia malayi EGF-like domain containing protein 0.0034 0.0017 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0044 0.0062
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0044 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0044 0.0062
Loa Loa (eye worm) PAN domain-containing protein 0.0099 0.0246 0.0349
Loa Loa (eye worm) trypsin family protein 0.0251 0.0784 0.1113
Loa Loa (eye worm) hypothetical protein 0.0145 0.0408 0.0579
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0067 0.0133 0.0188
Schistosoma mansoni hypothetical protein 0.0138 0.0382 0.0382
Echinococcus multilocularis GPCR, family 2 0.0064 0.0121 0.0121
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0251 0.0784 0.0784
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0263 0.0826 0.0826
Schistosoma mansoni egf-like domain protein 0.0055 0.0091 0.0091
Echinococcus multilocularis Mastin 0.0251 0.0784 0.0784
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0078 0.0172 0.0244
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0062
Loa Loa (eye worm) hypothetical protein 0.0099 0.0246 0.0349
Brugia malayi PAN domain containing protein 0.0099 0.0246 0.0349
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.0276 0.0276
Toxoplasma gondii microneme protein MIC17C 0.0099 0.0246 0.0461
Schistosoma mansoni hypothetical protein 0.0251 0.0784 0.0784
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0121 0.0172
Echinococcus granulosus Mastin 0.0251 0.0784 0.0784
Echinococcus multilocularis fibrillin 1 0.0055 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0017
Echinococcus multilocularis fat cadherin tumor suppressor 0.0034 0.0017 0.0017
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0044 0.0062
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2047 0.7129 0.7129
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0062
Echinococcus granulosus laminin 0.0055 0.0091 0.0091
Echinococcus granulosus protein jagged 1 0.0034 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0251 0.0784 0.1113
Schistosoma mansoni hypothetical protein 0.0064 0.0121 0.0121
Schistosoma mansoni cercarial elastase (S01 family) 0.0251 0.0784 0.0784
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0012 0.0065
Brugia malayi Calcium binding EGF domain containing protein 0.0055 0.0091 0.0129
Toxoplasma gondii PAN domain-containing protein 0.0099 0.0246 0.0461
Echinococcus multilocularis geminin 0.0364 0.1182 0.1182
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0012 0.0012
Brugia malayi Cadherin domain containing protein 0.0034 0.0017 0.0024
Echinococcus granulosus glycoprotein Antigen 5 0.0251 0.0784 0.0784
Echinococcus granulosus lamin 0.003 0.0003 0.0003
Onchocerca volvulus 0.0099 0.0246 0.0344
Echinococcus granulosus enteropeptidase 0.0251 0.0784 0.0784
Brugia malayi Muscleblind-like protein 0.0145 0.0408 0.0579
Onchocerca volvulus 0.0251 0.0784 0.1109
Echinococcus multilocularis protein jagged 2 0.0034 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0012
Onchocerca volvulus 0.0544 0.182 0.258
Brugia malayi MH2 domain containing protein 0.0122 0.0327 0.0464
Loa Loa (eye worm) notch protein 0.0034 0.0017 0.0024
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0036 0.0036
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0107 0.0273 0.0273
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0135 0.7864
Loa Loa (eye worm) hypothetical protein 0.0251 0.0784 0.1113
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0055 0.0091 0.0129
Schistosoma mansoni notch 0.0034 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0044 0.0062
Echinococcus granulosus intermediate filament protein 0.003 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0544 0.182 0.182
Onchocerca volvulus 0.0099 0.0246 0.0344
Echinococcus multilocularis laminin 0.0055 0.0091 0.0091
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0078 0.0172 0.0328
Onchocerca volvulus 0.0099 0.0246 0.0344
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0067 0.0134 0.0134
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0093 0.0093
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0078 0.0172 0.0244
Brugia malayi Trypsin family protein 0.0251 0.0784 0.1113
Mycobacterium ulcerans hypothetical protein 0.0251 0.0784 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0093 0.0093
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0093 0.0093
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0078 0.0172 0.0945
Echinococcus granulosus lamin dm0 0.003 0.0003 0.0003
Schistosoma mansoni notch 0.0034 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0453 0.1495 0.2123
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Toxoplasma gondii kringle domain-containing protein 0.0544 0.182 0.3415
Echinococcus multilocularis peregrin 0.0033 0.0012 0.0012
Schistosoma mansoni lozenge 0.0057 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Echinococcus granulosus neural cadherin 0.0034 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0044 0.0062
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Schistosoma mansoni lamin 0.003 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0044 0.0062
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0043 0.0061
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0067 0.0134 0.019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0044 0.0062
Brugia malayi hypothetical protein 0.0038 0.0029 0.0041
Brugia malayi EGF-like domain containing protein 0.0034 0.0017 0.0024
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0064 0.0121 0.0121
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0043 0.0061
Loa Loa (eye worm) hypothetical protein 0.0201 0.0608 0.0862
Schistosoma mansoni cercarial elastase (S01 family) 0.0251 0.0784 0.0784
Schistosoma mansoni lamin 0.003 0.0003 0.0003
Echinococcus multilocularis slit 2 protein 0.0034 0.0017 0.0017
Brugia malayi EGF-like domain containing protein 0.0034 0.0017 0.0024
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0251 0.0784 0.1113
Loa Loa (eye worm) hypothetical protein 0.0099 0.0246 0.0349
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0043 0.0235
Schistosoma mansoni hypothetical protein 0.0364 0.1182 0.1182
Schistosoma mansoni cercarial elastase (S01 family) 0.0251 0.0784 0.0784
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0034 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0017
Brugia malayi ecdysteroid receptor 0.0042 0.0044 0.0062
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0044 0.0044
Schistosoma mansoni cercarial elastase (S01 family) 0.0251 0.0784 0.0784
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0829 0.2824 0.2824
Onchocerca volvulus 0.0099 0.0246 0.0344
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.0608 0.0862
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Onchocerca volvulus 0.0099 0.0246 0.0344
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0093 0.0093
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0251 0.0784 0.0784
Schistosoma mansoni notch 0.0034 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0044 0.0062
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0044 0.0062
Loa Loa (eye worm) hypothetical protein 0.2023 0.7045 1
Brugia malayi EGF-like domain containing protein 0.0034 0.0017 0.0024
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0069 0.0098
Toxoplasma gondii microneme protein MIC17B 0.0099 0.0246 0.0461
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0012 0.0022
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0046 0.0059 0.0084
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0017
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0135 0.0192
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0044 0.0044
Echinococcus granulosus protein jagged 2 0.0034 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0067 0.0133 0.0188
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0078 0.0172 0.0323
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0036 0.0036
Echinococcus granulosus expressed protein 0.0049 0.0069 0.0069
Onchocerca volvulus 0.0099 0.0246 0.0344
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0044 0.0044
Leishmania major hypothetical protein, conserved 0.0544 0.182 1
Schistosoma mansoni hypothetical protein 0.0074 0.0156 0.0156
Brugia malayi hypothetical protein 0.0453 0.1495 0.2123
Schistosoma mansoni tar DNA-binding protein 0.0197 0.0594 0.0594
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.1007 0.143
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0251 0.0784 0.0784
Brugia malayi TAR-binding protein 0.0197 0.0594 0.0843
Brugia malayi PAN domain containing protein 0.0099 0.0246 0.0349
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0044 0.0062
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0099 0.0246 0.0349
Brugia malayi Protein kinase domain containing protein 0.0544 0.182 0.2584
Brugia malayi PHD-finger family protein 0.0033 0.0012 0.0017
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0042 0.0043 0.008
Onchocerca volvulus 0.0065 0.0125 0.0173
Onchocerca volvulus 0.0099 0.0246 0.0344
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Echinococcus granulosus protein jagged 2 0.0034 0.0017 0.0017
Loa Loa (eye worm) PAN domain-containing protein 0.0099 0.0246 0.0349
Brugia malayi intermediate filament protein 0.003 0.0003 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0044 0.0044
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0049 0.0069 0.0098
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0069 0.0379
Schistosoma mansoni cercarial elastase (S01 family) 0.0251 0.0784 0.0784
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.007 0.0099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0044 0.0044
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0044 0.0062
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.0577 0.0577
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0012 0.0022
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0116 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0197 0.0594 0.0594
Schistosoma mansoni cercarial elastase (S01 family) 0.0251 0.0784 0.0784
Toxoplasma gondii calcium binding egf domain-containing protein 0.0055 0.0091 0.0171
Loa Loa (eye worm) hypothetical protein 0.0067 0.0134 0.019
Brugia malayi Delta serrate ligand family protein 0.0034 0.0017 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0044 0.0062
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0069 0.0069
Onchocerca volvulus 0.0049 0.007 0.0095
Brugia malayi PAN domain containing protein 0.0099 0.0246 0.0349
Loa Loa (eye worm) hypothetical protein 0.0251 0.0784 0.1113
Echinococcus multilocularis transmembrane protease serine 3 0.0251 0.0784 0.0784
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0044 0.0044
Brugia malayi Trypsin family protein 0.2023 0.7045 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0251 0.0784 0.0784
Loa Loa (eye worm) DOMON domain-containing protein 0.0065 0.0125 0.0177
Echinococcus granulosus delta-like protein 1 0.0034 0.0017 0.0017
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0251 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.003 0.0003 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0044 0.0062
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0251 0.0784 0.0784
Loa Loa (eye worm) Notch2 0.0034 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0121 0.0121
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0121 0.0172
Loa Loa (eye worm) hypothetical protein 0.0055 0.0091 0.0129
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0382 0.0543
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0135 0.0113
Brugia malayi PAN domain containing protein 0.0099 0.0246 0.0349
Onchocerca volvulus 0.0042 0.0044 0.0058
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0044 0.0044
Echinococcus granulosus geminin 0.0364 0.1182 0.1182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0044 0.0062
Loa Loa (eye worm) hypothetical protein 0.0242 0.075 0.1064
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.0577 0.0577
Onchocerca volvulus 0.0065 0.0125 0.0173
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.0276 0.0276
Echinococcus multilocularis musashi 0.003 0.0003 0.0003
Toxoplasma gondii PAN/Apple domain-containing protein 0.0099 0.0246 0.0461
Schistosoma mansoni hypothetical protein 0.0315 0.1007 0.1007
Onchocerca volvulus Arrow homolog 0.0067 0.0133 0.0184
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0044 0.0058
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0057 0.0057
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0156 0.0156
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0121 0.0121
Brugia malayi Kringle domain containing protein 0.0544 0.182 0.2584
Brugia malayi Trypsin family protein 0.0251 0.0784 0.1113
Schistosoma mansoni tar DNA-binding protein 0.0197 0.0594 0.0594
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0017
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0116 0.0116
Toxoplasma gondii microneme protein MIC17A 0.0099 0.0246 0.0461
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0044 0.0044
Onchocerca volvulus 0.0251 0.0784 0.1109
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0044 0.0044
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0078 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0012 0.0017
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0044 0.0044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0044 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0044 0.0062
Echinococcus multilocularis Tolloid protein 1 0.0067 0.0134 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0044 0.0062
Brugia malayi PAN domain containing protein 0.0099 0.0246 0.0349
Giardia lamblia High cysteine protein 0.0034 0.0017 1
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0078 0.0172 0.0172
Toxoplasma gondii PAN domain-containing protein 0.1537 0.5329 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0044 0.0044
Loa Loa (eye worm) TAR-binding protein 0.0197 0.0594 0.0843
Loa Loa (eye worm) hypothetical protein 0.0064 0.0121 0.0172
Echinococcus multilocularis tar DNA binding protein 0.0197 0.0594 0.0594
Onchocerca volvulus 0.0034 0.0017 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0044 0.0062
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0078 0.0172 0.0244
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0069 0.0129
Schistosoma mansoni intermediate filament proteins 0.003 0.0003 0.0003
Brugia malayi GCC2 and GCC3 family protein 0.0034 0.0017 0.0024
Loa Loa (eye worm) intermediate filament protein 0.003 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0382 0.1247 0.177
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0062
Brugia malayi notch-like transmembrane receptor 0.0034 0.0017 0.0024
Echinococcus granulosus fibropellin Ia 0.0034 0.0017 0.0017
Brugia malayi Fibulin-1 precursor 0.0055 0.0091 0.0129
Brugia malayi SEA domain containing protein 0.0065 0.0125 0.0177
Toxoplasma gondii TIM10 family protein, putative 0.0049 0.0069 0.0129
Schistosoma mansoni hypothetical protein 0.0064 0.0121 0.0121
Brugia malayi PAN domain containing protein 0.0099 0.0246 0.0349
Echinococcus multilocularis fibropellin Ia 0.0034 0.0017 0.0017
Schistosoma mansoni cercarial elastase (S01 family) 0.0251 0.0784 0.0784
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.0017 0.0017
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0044 0.0044
Onchocerca volvulus 0.0065 0.0125 0.0173
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0297 0.0947 0.0947
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0078 0.0172 0.5
Schistosoma mansoni survival motor neuron protein 0.0049 0.007 0.007
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0251 0.0784 0.0784
Echinococcus multilocularis glycoprotein Antigen 5 0.0251 0.0784 0.0784
Onchocerca volvulus 0.0251 0.0784 0.1109
Brugia malayi steroid hormone receptor 0.0042 0.0044 0.0062
Brugia malayi RNA binding protein 0.0197 0.0594 0.0843
Brugia malayi hypothetical protein 0.0382 0.1247 0.177
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0044 0.0044
Schistosoma mansoni laminin gamma-3 chain 0.0034 0.0017 0.0017
Brugia malayi jmjC domain containing protein 0.0107 0.0276 0.0391
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0251 0.0784 0.0784
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2023 0.7045 0.7045
Brugia malayi Muscle positioning protein 4 0.0099 0.0246 0.0349
Loa Loa (eye worm) runx1 0.0057 0.0097 0.0137
Echinococcus granulosus muscleblind protein 0.0145 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0099 0.0246 0.0349
Echinococcus multilocularis tissue type plasminogen activator 0.0544 0.182 0.182
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0012 0.0012
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0024
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0044 0.0044
Echinococcus granulosus neurogenic locus notch protein 4 0.0034 0.0017 0.0017
Echinococcus granulosus protein jagged 1 0.0034 0.0017 0.0017
Toxoplasma gondii EGF family domain-containing protein 0.0034 0.0017 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0116 0.0116
Onchocerca volvulus 0.2023 0.7045 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0327 0.0464
Echinococcus granulosus neurogenic locus protein delta 0.0034 0.0017 0.0017
Echinococcus multilocularis neural cadherin 0.0034 0.0017 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0044 0.0044
Loa Loa (eye worm) PAN domain-containing protein 0.0099 0.0246 0.0349
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0121 0.0121
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0135 0.0192
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0069 0.0069
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0017 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0044 0.0062
Loa Loa (eye worm) PAN domain-containing protein 0.0099 0.0246 0.0349
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0078 0.0172 0.0218
Brugia malayi EGF-like domain containing protein 0.0034 0.0017 0.0024
Toxoplasma gondii calcium binding egf domain-containing protein 0.0055 0.0091 0.0171
Echinococcus multilocularis Protein lozenge 0.0057 0.0097 0.0097
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0121 0.0172
Brugia malayi PAN domain containing protein 0.0099 0.0246 0.0349
Brugia malayi EGF-like domain containing protein 0.0034 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.0062
Schistosoma mansoni notch 0.0034 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0544 0.182 0.2584
Schistosoma mansoni hypothetical protein 0.0364 0.1182 0.1182
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0064 0.0121 0.0121
Schistosoma mansoni microtubule-associated protein tau 0.2859 1 1
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0049 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.0074 0.0156 0.5724
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0408 0.0408
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0042 0.0043 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0132
Onchocerca volvulus Slit protein homolog 0.0034 0.0017 0.0019
Echinococcus multilocularis lamin 0.003 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0069 0.0098
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0135 0.0192
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.0594 0.0843
Echinococcus granulosus tissue type plasminogen activator 0.0544 0.182 0.182
Brugia malayi PAN domain containing protein 0.0099 0.0246 0.0349
Brugia malayi PAN domain containing protein 0.0099 0.0246 0.0349

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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