Detailed information for compound 1068977

Basic information

Technical information
  • TDR Targets ID: 1068977
  • Name: [3-[(2-methyl-2,3-dihydro-1-benzofuran-7-yl)m ethyl]-3,9-diazaspiro[5.5]undecan-9-yl]-pyrid in-4-ylmethanone
  • MW: 405.533 | Formula: C25H31N3O2
  • H donors: 0 H acceptors: 2 LogP: 3.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1Cc2c(O1)c(ccc2)CN1CCC2(CC1)CCN(CC2)C(=O)c1ccncc1
  • InChi: 1S/C25H31N3O2/c1-19-17-21-3-2-4-22(23(21)30-19)18-27-13-7-25(8-14-27)9-15-28(16-10-25)24(29)20-5-11-26-12-6-20/h2-6,11-12,19H,7-10,13-18H2,1H3
  • InChiKey: JQIOFPJNEBMYKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [3-[(2-methyl-2,3-dihydrobenzofuran-7-yl)methyl]-3,9-diazaspiro[5.5]undecan-9-yl]-(4-pyridyl)methanone
  • [3-[(2-methyl-2,3-dihydro-1-benzofuran-7-yl)methyl]-3,9-diazaspiro[5.5]undecan-9-yl]-pyridin-4-yl-methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 8 Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0066 0.0278
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0005
Echinococcus multilocularis deoxyribonuclease 1 2 0.0008 0.0001 0.0004
Trypanosoma brucei trypanothione reductase 0.0048 0.0309 0.1145
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.021
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0237 0.1272
Brugia malayi beta-lactamase family protein 0.0039 0.0237 0.0326
Schistosoma mansoni ferritin 0.0009 0.0008 0.0024
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0066 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Brugia malayi CXXC zinc finger family protein 0.0062 0.0416 0.0573
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.088 0.4746
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0001 0.0005
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0001 0.0005
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0291 0.0924
Loa Loa (eye worm) hypothetical protein 0.0039 0.0237 0.0933
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.006
Echinococcus granulosus dnaJ subfamily B 0.0415 0.3153 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0049
Brugia malayi Thioredoxin reductase 0.0048 0.0309 0.0426
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0326 0.1757
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.088 0.4746
Loa Loa (eye worm) hypothetical protein 0.0164 0.1205 0.4749
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0066 0.024
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0005 0.0017
Trichomonas vaginalis helicase, putative 0.0014 0.0045 0.021
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0116 0.0428
Leishmania major hypothetical protein, conserved 0.0039 0.0237 0.0877
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0256 0.0811
Echinococcus multilocularis ferritin 0.0009 0.0008 0.0024
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0066 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.021
Leishmania major GTP-binding protein, putative 0.0023 0.0116 0.0428
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0237 0.0877
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0066 0.1112
Loa Loa (eye worm) glutaminase 0.028 0.2104 0.8291
Loa Loa (eye worm) hypothetical protein 0.0039 0.0237 0.0933
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0237 0.1093
Brugia malayi beta-lactamase family protein 0.0039 0.0237 0.0326
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0032 0.0044
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0326 0.1035
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0005 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.021
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0005 0.0017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0015 0.0049
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0001 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0066 0.024
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0005 0.0019
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0005 0.0017
Schistosoma mansoni nocturnin 0.0008 0.0001 0.0004
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0066 0.1112
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0037 0.0117
Leishmania major DNA polymerase eta, putative 0.0022 0.0107 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0049
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0056 0.0177
Giardia lamblia DINP protein human, muc B family 0.0022 0.0107 0.0393
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0107 0.0339
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0066 0.024
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0107 0.0571
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Echinococcus multilocularis expressed protein 0.0009 0.0008 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0021
Schistosoma mansoni coup transcription factor 0.001 0.0015 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0237 0.1119
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0309 0.1145
Schistosoma mansoni ferritin 0.0009 0.0008 0.0024
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0107 0.0339
Brugia malayi nuclear hormone receptor 0.001 0.0015 0.0021
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0066 0.0307
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.088 0.4746
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0107 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.021
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.021
Brugia malayi beta-lactamase 0.0039 0.0237 0.0326
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0015 0.0049
Trypanosoma brucei unspecified product 0.0015 0.0054 0.0197
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0005 0.0017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.1037 0.4087
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0001 0.0002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0001 0.0002
Schistosoma mansoni ap endonuclease 0.0041 0.0256 0.0811
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0015 0.0014
Brugia malayi ecdysteroid receptor 0.001 0.0015 0.0021
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0531 0.6004
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0037 0.0051
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0049
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0037 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0054 0.0197
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1037 0.329
Brugia malayi glutathione reductase 0.0048 0.0309 0.0426
Giardia lamblia Telomerase catalytic subunit 0.0355 0.2686 1
Echinococcus granulosus cpg binding protein 0.0065 0.0443 0.1405
Schistosoma mansoni ferritin light chain 0.0009 0.0008 0.0024
Echinococcus granulosus transcription factor Dp 1 0.0042 0.026 0.0824
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0107 0.0393
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0107 0.0147
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0142 0.0523
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0066 0.0209
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.1852 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0021
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0066 0.024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0006 0.0018
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0008 0.0034
Entamoeba histolytica Ran family GTPase 0.0023 0.0116 0.233
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.026 0.0824
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0256 0.0948
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0237 0.0877
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0256 0.1184
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0237 0.0751
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0066 0.0091
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0015 0.0049
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0107 0.0502
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0237 0.1272
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0015 0.006
Echinococcus granulosus synaptojanin 1 0.0008 0.0001 0.0004
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0237 0.1272
Entamoeba histolytica hypothetical protein 0.0025 0.0134 0.2699
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0001 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0045 0.021
Onchocerca volvulus 0.0164 0.1205 0.1204
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0001 0.0002
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0262 0.0971
Trichomonas vaginalis glutaminase, putative 0.028 0.2104 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0256 0.4741
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0256 0.0948
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0107 0.0339
Trypanosoma brucei unspecified product 0.0015 0.0054 0.0197
Echinococcus granulosus dna polymerase eta 0.0022 0.0107 0.0339
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0256 0.4803
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0021
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0001 0.0004
Echinococcus granulosus FTZ F1 alpha 0.001 0.0015 0.0049
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0237 0.0877
Schistosoma mansoni ran 0.0023 0.0116 0.0369
Echinococcus multilocularis synaptojanin 1 0.0008 0.0001 0.0004
Plasmodium falciparum glutathione reductase 0.0017 0.0066 0.024
Schistosoma mansoni hypothetical protein 0.0415 0.3153 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0056 0.0177
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0134 0.0633
Brugia malayi Telomerase reverse transcriptase 0.0944 0.7251 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0001 0.0002
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0005 0.0017
Plasmodium falciparum glutathione reductase 0.0048 0.0309 0.1145
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0005 0.0019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.1109 0.3516
Echinococcus granulosus snurportin 1 0.0336 0.2538 0.8049
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0142 0.1538
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0015 0.006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0259 0.1227
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0282 0.0895
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0107 0.0393
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0015 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0107 0.0393
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0134 0.0496
Leishmania major importin beta-1 subunit, putative 0.0025 0.0134 0.0496
Schistosoma mansoni cpg binding protein 0.0062 0.0416 0.1318
Loa Loa (eye worm) hypothetical protein 0.0039 0.0237 0.0932
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0326 0.1757
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0531 0.1685
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.088 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0531 0.1974
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0309 0.1216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1037 0.329
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Onchocerca volvulus 0.0039 0.0237 0.0235
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.021
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0008 0.0001 0.0004
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0531 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0066 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0142 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0107 0.0571
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0049
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0282 0.0895
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0005 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0015 0.006
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0066 0.024
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.1143 0.1576
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0256 0.0811
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0015 0.0049
Plasmodium vivax telomerase reverse transcriptase, putative 0.0355 0.2686 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0145
Plasmodium falciparum thioredoxin reductase 0.0017 0.0066 0.024
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0066 0.0348
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0015 0.0049
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0495 1
Schistosoma mansoni carbon catabolite repressor protein 0.0008 0.0001 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0107 0.0393
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0116 0.0369
Brugia malayi steroid hormone receptor 0.001 0.0015 0.0021
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0531 0.1685
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0863 0.34
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0005 0.0017
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0015 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0021
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0107 0.0474
Loa Loa (eye worm) hypothetical protein 0.0039 0.0237 0.0933
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0054 0.0197
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0066 0.024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0049
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0355 0.2686 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0116 0.0428
Onchocerca volvulus 0.0039 0.0237 0.0235
Onchocerca volvulus 0.0039 0.0237 0.0235
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0237 0.0326
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0056 0.0177
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.021
Schistosoma mansoni ran 0.0023 0.0116 0.0369
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0015 0.0021
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0531 1
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0256 0.121
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0056 0.0177
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0291 0.138
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0066 0.0278
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0355 0.2686 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0116 0.0428
Toxoplasma gondii exonuclease III APE 0.0041 0.0256 0.0948
Echinococcus multilocularis traf and tnf receptor associated protein 0.0008 0.0001 0.0004
Trypanosoma brucei unspecified product 0.0022 0.0107 0.0393
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1037 0.329
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0005 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.021
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0116 0.0428
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0083 0.0115
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Echinococcus granulosus neutral sphingomyelinase 0.0008 0.0001 0.0004
Leishmania major trypanothione reductase 0.0048 0.0309 0.1145
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0001 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0256 0.121
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0116 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0021
Plasmodium falciparum thioredoxin reductase 0.0048 0.0309 0.1145
Loa Loa (eye worm) beta-lactamase 0.0039 0.0237 0.0933
Onchocerca volvulus 0.001 0.0015 0.0014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0066 0.0278
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0001 0.0002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0015 0.0049
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0181 0.0668
Plasmodium vivax glutathione reductase, putative 0.0048 0.0309 0.1145
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Mycobacterium tuberculosis Conserved protein 0.0039 0.0237 0.1272
Echinococcus multilocularis dna polymerase eta 0.0022 0.0107 0.0339
Loa Loa (eye worm) glutaminase 2 0.028 0.2104 0.8291
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0085 0.027
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0237 0.0933
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0015 0.0049
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0107 0.0339
Schistosoma mansoni cpg binding protein 0.0065 0.0443 0.1405
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1037 0.329
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0107 0.0339
Brugia malayi Cyclic-nucleotide gated cation channel 0.0009 0.0005 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0066 0.024
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.006
Trichomonas vaginalis esterase, putative 0.0039 0.0237 0.1119
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0237 0.1272
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0005 0.0017
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0531 0.1685
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0237 0.2628
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0066 0.024
Brugia malayi CCR4 0.0008 0.0001 0.0002
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0066 0.024
Schistosoma mansoni cpg binding protein 0.0065 0.0443 0.1405
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0066 0.024
Trypanosoma brucei telomerase reverse transcriptase 0.0355 0.2686 1
Schistosoma mansoni ap endonuclease 0.0041 0.0256 0.0811
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0107 0.0393
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0015 0.006
Mycobacterium ulcerans glutaminase 0.028 0.2104 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0066 0.024
Schistosoma mansoni apoferritin-2 0.0009 0.0008 0.0024
Schistosoma mansoni DNA polymerase eta 0.0022 0.0107 0.0339
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1037 0.329
Mycobacterium leprae Probable lipase LipE 0.0039 0.0237 0.2628
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0291 0.1081
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0142 0.2649
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0282 0.0389
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0336 0.2538 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.1756 0.6916
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0005 0.0017
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0181 0.0668
Loa Loa (eye worm) acetyltransferase 0.0156 0.1143 0.4502
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0531 0.2498
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0015 0.0049
Echinococcus multilocularis cpg binding protein 0.0065 0.0443 0.1405
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0015 0.0049
Schistosoma mansoni ferritin light chain 0.0009 0.0008 0.0024
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0066 0.0307
Mycobacterium tuberculosis Probable reductase 0.0109 0.0785 0.4235
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0134 0.0633
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0291 0.1081
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0785 0.4235
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0237 0.0933
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0032 0.0044
Schistosoma mansoni apoferritin-2 0.0009 0.0008 0.0024
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0008 0.0117
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.021
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0015 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0237 0.0877
Loa Loa (eye worm) hypothetical protein 0.0039 0.0237 0.0933
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0262 0.0971
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0015 0.0049
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0282 0.1111
Brugia malayi hypothetical protein 0.0164 0.1205 0.1662
Plasmodium vivax importin-beta 2, putative 0.0031 0.0181 0.0668
Echinococcus granulosus ferritin 0.0009 0.0008 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0015 0.0021
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0116 0.0369
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.1143 0.3623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0015 0.006
Mycobacterium ulcerans hypothetical protein 0.0039 0.0237 0.1093
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0066 0.024
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0256 0.0353
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0953 0.3021
Mycobacterium ulcerans beta-lactamase 0.0039 0.0237 0.1093
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0015 0.0049
Loa Loa (eye worm) hypothetical protein 0.0077 0.0531 0.2093
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0015 0.006
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0309 0.1145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0015 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0066 0.024
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0107 0.0421
Toxoplasma gondii ABC1 family protein 0.0039 0.0237 0.0877
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0066 0.024
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0001 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0056 0.0177
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.3153 1
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0037 0.0117
Loa Loa (eye worm) glutathione reductase 0.0048 0.0309 0.1216
Brugia malayi nuclear receptor NHR-88 0.001 0.0015 0.0021
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0107 0.214
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0001 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0066 0.024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0021
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0256 0.0948
Plasmodium falciparum importin beta, putative 0.0031 0.0181 0.0668
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0049
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0495 0.1838
Brugia malayi MH2 domain containing protein 0.0119 0.0863 0.119
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.006
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0015 0.0021
Brugia malayi follicle stimulating hormone receptor 0.0235 0.1756 0.2421
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.021
Echinococcus granulosus dna polymerase kappa 0.0022 0.0107 0.0339
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0256 0.5158
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0015 0.0049
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0037 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0021
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0066 0.024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0049
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0237 0.1119
Schistosoma mansoni nuclear hormone receptor 0.001 0.0015 0.0049
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0008 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0021
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0495 0.0682
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0309 0.0979
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0045 0.021
Schistosoma mansoni hypothetical protein 0.0336 0.2538 0.8049
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0291 0.138
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0237 0.1119
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0008 0.0001 0.0004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0049
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0495 0.1569
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0785 0.4235
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0015 0.0049
Schistosoma mansoni importin beta-1 0.0031 0.0181 0.0573
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0066 0.024
Schistosoma mansoni ferritin 0.0009 0.0008 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0015 0.006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0256 0.0948
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0237 0.1119
Trichomonas vaginalis ferritin, putative 0.0009 0.0008 0.003
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0008 0.0001 0.0004
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0107 0.0393
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0237 0.1272
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0008 0.0001 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0021
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0256 0.0948
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0262 0.5282
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0015 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Echinococcus granulosus expressed protein 0.0009 0.0008 0.0024
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0237 0.1093
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0021
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0495 0.1838
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0495 0.1838
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0531 0.1974
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0005 0.0017
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0785 0.4235
Schistosoma mansoni cript-related 0.0008 0.0001 0.0004
Schistosoma mansoni synaptojanin 0.0008 0.0001 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0237 0.1119
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0085 0.0335
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0021
Mycobacterium tuberculosis Conserved protein 0.0039 0.0237 0.1272
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1037 0.329
Toxoplasma gondii thioredoxin reductase 0.0048 0.0309 0.1145
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0005 0.0021
Schistosoma mansoni neutral sphingomyelinase 0.0008 0.0001 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0054 0.0197
Mycobacterium tuberculosis Conserved protein 0.0039 0.0237 0.1272
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0037 0.0117
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0107 0.0502
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0711
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0531 0.1974
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0416 0.1638
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0237 0.1272
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1037 0.329
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0785 0.4235
Leishmania major DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0005 0.0017
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0066 0.024
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0237 0.0751
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.1143 0.3623
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0291 0.1081
Treponema pallidum NADH oxidase 0.0017 0.0066 0.1217
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0134 0.0633
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0037 0.0117
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0107 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.021
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0314 0.0995
Trichomonas vaginalis ran, putative 0.0023 0.0116 0.0547
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0495 0.1838
Toxoplasma gondii hypothetical protein 0.0026 0.0142 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.021
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0326 0.3657
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0008 0.0034
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0005 0.0017
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0005 0.0017
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0309 0.1661
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0785 0.8915
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0066 0.024
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0181 0.0573
Schistosoma mansoni glutaminase 0.028 0.2104 0.6673
Mycobacterium ulcerans lipase LipD 0.0039 0.0237 0.1093
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0049
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0116 0.0458
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0256 0.0948
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0066 0.0209
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0237 0.0751
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0495 0.1569
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0531 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0066 0.024
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0314 0.0995
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0256 0.1008
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0008 0.0001 0.0005
Toxoplasma gondii RNA-directed DNA polymerase 0.0355 0.2686 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0021
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0785 0.4235
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0107 0.0147
Brugia malayi glutaminase DH11.1 0.028 0.2104 0.2902
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0005
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0116 0.0428
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0237 0.0751
Echinococcus multilocularis neutral sphingomyelinase 0.0008 0.0001 0.0004
Brugia malayi RNA, U transporter 1 0.0089 0.063 0.0869
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0256 0.0948
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0001 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0049
Leishmania major telomerase reverse transcriptase, putative 0.0355 0.2686 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0015 0.0049
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.1037 0.1431
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0085 0.027
Brugia malayi Importin beta-1 subunit 0.0031 0.0181 0.0249
Schistosoma mansoni hypothetical protein 0.0008 0.0001 0.0004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0309 0.0979
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0495 0.1569
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0049
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0874 0.325
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0107 0.0393
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0326 0.1035
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0531 0.2498
Loa Loa (eye worm) hypothetical protein 0.0039 0.0237 0.0933
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0001 0.0002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0237 0.1272
Echinococcus granulosus importin subunit beta 1 0.0031 0.0181 0.0573
Schistosoma mansoni synaptojanin 0.0008 0.0001 0.0004
Echinococcus multilocularis snurportin 1 0.0336 0.2538 0.8049
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0259 0.1227
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0531 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0066 0.0209
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0116 0.016
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0116 0.0428
Brugia malayi Probable ClpP-like protease 0.0077 0.0531 0.0733
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0066 0.024
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0531 0.1974
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0015 0.0049
Schistosoma mansoni ferritin 0.0009 0.0008 0.0024
Echinococcus granulosus traf and tnf receptor associated protein 0.0008 0.0001 0.0004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0256 0.1375
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0001 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0863 0.34
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0495 0.1949
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0181 0.0668
Plasmodium falciparum telomerase reverse transcriptase 0.0355 0.2686 1
Onchocerca volvulus 0.0062 0.0416 0.0414

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.68 Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology ChEMBL. 19954248
IC50 (binding) = 5.09 Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method ChEMBL. 19954248
IC50 (functional) = 6.89 Antagonist activity at human CCR8 ChEMBL. 19954248

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.