Detailed information for compound 108078

Basic information

Technical information
  • TDR Targets ID: 108078
  • Name: [(2R)-3-[4-(2,2-dimethylpropanoyloxy)phenyl]- 4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl] -2H-chromen-7-yl] 2,2-dimethylpropanoate
  • MW: 625.794 | Formula: C39H47NO6
  • H donors: 0 H acceptors: 2 LogP: 8.2 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C(C)(C)C)Oc1ccc2c(c1)O[C@@H](C(=C2C)c1ccc(cc1)OC(=O)C(C)(C)C)c1ccc(cc1)OCCN1CCCCC1
  • InChi: 1S/C39H47NO6/c1-26-32-20-19-31(45-37(42)39(5,6)7)25-33(32)46-35(34(26)27-11-17-30(18-12-27)44-36(41)38(2,3)4)28-13-15-29(16-14-28)43-24-23-40-21-9-8-10-22-40/h11-20,25,35H,8-10,21-24H2,1-7H3/t35-/m1/s1
  • InChiKey: OEKMGABCSLYWOP-PGUFJCEWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R)-3-[4-(2,2-dimethylpropanoyloxy)phenyl]-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-yl] 2,2-dimethylpropanoate
  • 2,2-dimethylpropanoic acid [(2R)-3-[4-(2,2-dimethyl-1-oxopropoxy)phenyl]-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-1-benzopyran-7-yl] ester
  • 2,2-dimethylpropionic acid [(2R)-4-methyl-2-[4-(2-piperidinoethoxy)phenyl]-3-(4-pivaloyloxyphenyl)-2H-chromen-7-yl] ester
  • 2,2-dimethylpropanoic acid [(2R)-3-[4-(2,2-dimethyl-1-oxopropoxy)phenyl]-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-yl] ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis intersectin 2 0.0024 0.0075 0.0055
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0739 0.2432
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0361 0.0806
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0039 0.0059
Plasmodium falciparum nitric oxide synthase, putative 0.0029 0.012 0.4965
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0044 0.0244 0.0224
Echinococcus granulosus dro:myosuppressin receptor 0.0044 0.0244 0.0224
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0244 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0184 0.0548
Onchocerca volvulus 0.0044 0.0244 0.1097
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0041 0.0021
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus granulosus lamin dm0 0.0027 0.0098 0.0078
Brugia malayi hypothetical protein 0.0044 0.0244 0.0752
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0251 0.1036
Plasmodium falciparum importin beta, putative 0.0029 0.0113 0.4408
Mycobacterium tuberculosis Probable lipase LipE 0.0083 0.0561 0.1281
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0083 0.0561 0.1829
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0257
Loa Loa (eye worm) FAD binding domain-containing protein 0.0018 0.0028 0.0019
Brugia malayi putative neuropeptide receptor NPR1 0.0044 0.0244 0.0752
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0375 0.2969 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0245 0.1899 0.1882
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0593 0.1356
Schistosoma mansoni myosin xvIII 0.0044 0.0244 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0184 0.0548
Brugia malayi Peripheral plasma membrane protein CASK 0.0024 0.0075 0.0179
Brugia malayi Fes/CIP4 homology domain containing protein 0.0024 0.0075 0.0179
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0022 0.0002
Loa Loa (eye worm) TK/ABL protein kinase 0.0031 0.0137 0.0388
Schistosoma mansoni biogenic amine (5HT) receptor 0.0044 0.0244 0.0244
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0024 0.0075 0.0245
Entamoeba histolytica BAR/SH3 domain containing protein 0.0024 0.0075 0.0231
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Loa Loa (eye worm) beta-lactamase 0.0083 0.0561 0.1829
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0044 0.0244 0.0752
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0184 0.0184
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0184 0.0164
Schistosoma mansoni hypothetical protein 0.0025 0.008 0.008
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0251 0.0231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0179 0.2654
Schistosoma mansoni hypothetical protein 0.0044 0.0244 0.0244
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0041 0.0065
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0041 0.005
Echinococcus granulosus sex peptide receptor 0.0044 0.0244 0.0224
Echinococcus multilocularis somatostatin receptor 0.0044 0.0244 0.0224
Onchocerca volvulus 0.0044 0.0244 0.1097
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.1424 0.4756
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0179 0.0159
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0024 0.0075 0.0055
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.0277 0.0277
Echinococcus granulosus tyrosine protein kinase Fyn 0.0245 0.1899 0.1882
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Echinococcus granulosus SH2 motif 0.0025 0.008 0.006
Giardia lamblia Nitric oxide synthase, inducible 0.0026 0.0093 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0197 0.15 0.1482
Loa Loa (eye worm) hypothetical protein 0.0092 0.0634 0.2078
Echinococcus multilocularis tensin 0.0025 0.008 0.006
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0245 0.1899 0.1882
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0104 0.1051
Echinococcus multilocularis tyrosine kinase 0.0031 0.0137 0.0117
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0672 0.1545
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.1424 0.1406
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0561 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0184 0.0164
Echinococcus multilocularis snurportin 1 0.0304 0.2384 0.2369
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0029 0.012 0.01
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0104 0.3814
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0022 0.0002
Brugia malayi Protein kinase domain containing protein 0.0031 0.0137 0.0388
Echinococcus multilocularis lamin 0.0027 0.0098 0.0078
Echinococcus granulosus expressed protein 0.0024 0.0075 0.0055
Trichomonas vaginalis sulfite reductase, putative 0.0029 0.012 0.045
Loa Loa (eye worm) hypothetical protein 0.0083 0.0561 0.1829
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0184 0.0164
Echinococcus granulosus tyrosine protein kinase Lyn 0.0246 0.1906 0.189
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0051 0.0182
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.0231
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0191 0.2754
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.0244 0.0752
Brugia malayi Variant SH3 domain containing protein 0.0025 0.008 0.0196
Schistosoma mansoni ran 0.0021 0.0051 0.0051
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0024 0.0075 0.0055
Schistosoma mansoni ran 0.0021 0.0051 0.0051
Echinococcus multilocularis g-protein coupled receptor 0.0044 0.0244 0.0224
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0068 0.052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Brugia malayi SH2 domain containing protein 0.0031 0.0137 0.0388
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0075 0.0179
Schistosoma mansoni hypothetical protein 0.1229 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0184 0.0548
Echinococcus multilocularis geminin 0.1229 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Onchocerca volvulus 0.0044 0.0244 0.1097
Brugia malayi Pre-SET motif family protein 0.0033 0.015 0.0435
Plasmodium vivax importin-beta 2, putative 0.0029 0.0113 0.1214
Echinococcus granulosus hypothetical protein 0.0044 0.0244 0.0224
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0184 0.0801
Echinococcus granulosus c src tyrosine kinase 0.0055 0.0334 0.0314
Loa Loa (eye worm) guanylate kinase 0.0024 0.0075 0.0179
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0029 0.012 0.1525
Schistosoma mansoni hypothetical protein 0.0044 0.0237 0.0237
Echinococcus multilocularis musashi 0.0027 0.0098 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0075 0.0648
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0029 0.012 0.1525
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0191 0.2886
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.0244 0.0244
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0179
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0561 0.243
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0024 0.0075 0.0055
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0083 0.0561 0.1829
Echinococcus multilocularis SH2 motif 0.0025 0.008 0.006
Onchocerca volvulus 0.0044 0.0244 0.1097
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0184 0.0184
Trichomonas vaginalis esterase, putative 0.0083 0.0561 0.243
Brugia malayi glutathione reductase 0.0038 0.0191 0.0574
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0039 0.0019
Plasmodium falciparum thioredoxin reductase 0.0038 0.0191 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0104 0.1213
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0026 0.0093 0.0326
Mycobacterium ulcerans esterase/lipase LipP 0.0083 0.0561 0.243
Onchocerca volvulus 0.0044 0.0244 0.1097
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.0244 0.0224
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0051 0.003
Echinococcus granulosus alpha 1A adrenergic receptor 0.0044 0.0244 0.0224
Echinococcus granulosus neuropeptide FF receptor 2 0.0044 0.0244 0.0224
Loa Loa (eye worm) inositol-1 0.0037 0.0179 0.0533
Entamoeba histolytica BAR/SH3 domain containing protein 0.0024 0.0075 0.0231
Schistosoma mansoni vav2 0.0025 0.008 0.008
Brugia malayi RE15519p 0.0044 0.0244 0.0752
Schistosoma mansoni sorbin 0.0024 0.0075 0.0075
Schistosoma mansoni tyrosine kinase 0.0245 0.1899 0.1899
Echinococcus multilocularis N chimaerin 0.0025 0.008 0.006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0184 0.0548
Echinococcus granulosus g-protein coupled receptor 0.0044 0.0244 0.0224
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0075 0.0179
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0361 0.153
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0024 0.0075 0.0075
Loa Loa (eye worm) glutaminase 0.0288 0.2247 0.7548
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0184 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0075 0.0245
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0044 0.0244 0.0752
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0024 0.0075 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0055 0.0334 0.0314
Onchocerca volvulus 0.0044 0.0244 0.1097
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0025 0.008 0.0196
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0593 0.1356
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0179
Onchocerca volvulus 0.0044 0.0244 0.1097
Echinococcus multilocularis dna polymerase kappa 0.002 0.0041 0.0021
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Schistosoma mansoni biogenic amine (5HT) receptor 0.0044 0.0244 0.0244
Schistosoma mansoni patched 1 0.0045 0.0251 0.0251
Echinococcus granulosus fmrfamide receptor 0.0044 0.0244 0.0224
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0184 0.0184
Onchocerca volvulus Putative cortactin 0.0024 0.0075 0.0261
Echinococcus granulosus biogenic amine 5HT receptor 0.0044 0.0244 0.0224
Schistosoma mansoni ferritin light chain 0.0017 0.002 0.002
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0051 0.0097
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0055 0.0334 0.0334
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0593 0.1356
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0024 0.0075 0.0648
Brugia malayi neuropeptide F receptor 0.0044 0.0244 0.0752
Onchocerca volvulus 0.0025 0.008 0.0286
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0044 0.0244 0.0224
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0041 0.005
Entamoeba histolytica hypothetical protein, conserved 0.0024 0.0075 0.0231
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0098 0.0257
Echinococcus multilocularis SH2 motif 0.0025 0.008 0.006
Schistosoma mansoni histamine h1 receptor 0.0044 0.0244 0.0244
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0044 0.0244 0.0752
Brugia malayi Pre-SET motif family protein 0.0231 0.1778 0.5957
Loa Loa (eye worm) melatonin receptor type 1A 0.0044 0.0244 0.0752
Echinococcus multilocularis serotonin receptor 0.0044 0.0244 0.0224
Onchocerca volvulus 0.0044 0.0244 0.1097
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0184 0.0548
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.1424 0.1406
Echinococcus granulosus expressed conserved protein 0.0025 0.008 0.006
Schistosoma mansoni nuclear receptor 0.0018 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0031 0.0137 0.0117
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0137 0.0388
Echinococcus multilocularis neuropeptide receptor A26 0.0491 0.392 0.3908
Onchocerca volvulus 0.0044 0.0244 0.1097
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0153 0.1137 0.3784
Schistosoma mansoni hypothetical protein 0.0044 0.0237 0.0237
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0137 0.0388
Trypanosoma cruzi p450 reductase, putative 0.0029 0.012 0.1525
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.0244 0.0752
Trichomonas vaginalis penicillin-binding protein, putative 0.0083 0.0561 0.243
Brugia malayi Protein kinase domain containing protein 0.0031 0.0137 0.0388
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0245 0.1899 0.1882
Brugia malayi RhoGAP domain containing protein 0.0025 0.008 0.0196
Schistosoma mansoni hypothetical protein 0.0044 0.0244 0.0244
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0184 0.0164
Brugia malayi Protein kinase domain containing protein 0.0031 0.0137 0.0388
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Brugia malayi steroid hormone receptor 0.0037 0.0184 0.0548
Schistosoma mansoni alpha-1 adrenergic receptor 0.0044 0.0244 0.0244
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0083 0.0561 0.1281
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Echinococcus granulosus neuropeptide receptor A26 0.0491 0.392 0.3908
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0075 0.0179
Brugia malayi Protein kinase domain containing protein 0.0031 0.0137 0.0388
Mycobacterium ulcerans beta-lactamase 0.0083 0.0561 0.243
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0044 0.0244 0.0224
Entamoeba histolytica unconventional myosin IB 0.0024 0.0075 0.0231
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.0244 0.0752
Onchocerca volvulus 0.0031 0.0137 0.0567
Brugia malayi beta-lactamase family protein 0.0083 0.0561 0.1829
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.0244 0.0224
Loa Loa (eye worm) TK protein kinase 0.0197 0.15 0.5013
Loa Loa (eye worm) SH2 domain-containing protein 0.0025 0.008 0.0196
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0029 0.012 0.1525
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0031 0.0137 0.0117
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0244 0.0224
Schistosoma mansoni tyrosine kinase 0.0055 0.0334 0.0334
Onchocerca volvulus Neuropeptide F receptor homolog 0.0044 0.0244 0.1097
Brugia malayi Variant SH3 domain containing protein 0.0025 0.008 0.0196
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0361 0.153
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0048 0.0277 0.0864
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Brugia malayi SH2 domain containing protein 0.0025 0.008 0.0196
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0029 0.012 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0179
Plasmodium vivax SET domain protein, putative 0.0033 0.015 0.1953
Echinococcus multilocularis neuropeptide s receptor 0.0491 0.392 0.3908
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Schistosoma mansoni neuropeptide receptor 0.0044 0.0244 0.0244
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0184 0.0164
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0388
Brugia malayi Spectrin alpha chain 0.0024 0.0075 0.0179
Mycobacterium tuberculosis Probable hydrolase 0.0083 0.0561 0.1281
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Brugia malayi hypothetical protein 0.002 0.0039 0.0059
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0184 0.0184
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0041 0.0065
Onchocerca volvulus 0.0033 0.015 0.0635
Brugia malayi RNA, U transporter 1 0.0081 0.0545 0.1776
Echinococcus granulosus methionine synthase reductase 0.0018 0.0028 0.0007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0276 0.0257
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.015 0.013
Brugia malayi cytokine inducible SH2-containing protein 5 0.0025 0.008 0.0196
Schistosoma mansoni tyrosine kinase 0.0031 0.0137 0.0137
Echinococcus granulosus growth factor receptor bound protein 2 0.0048 0.0277 0.0257
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0029 0.012 0.01
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0137 0.0388
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.0244 0.0752
Echinococcus granulosus snurportin 1 0.0304 0.2384 0.2369
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0184 0.0801
Schistosoma mansoni intermediate filament proteins 0.0027 0.0098 0.0098
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0055 0.0334 0.0314
Echinococcus granulosus biogenic amine 5HT receptor 0.0044 0.0244 0.0224
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0098 0.0257
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0025 0.008 0.006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0184 0.0184
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0024 0.0075 0.0075
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0044 0.0244 0.0752
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0179
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0279
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0243
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0025 0.008 0.006
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0037 0.0184 0.0548
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0068 0.0216
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.0244 0.0244
Onchocerca volvulus 0.0037 0.0184 0.0801
Echinococcus granulosus suppressor of cytokine signaling 6 0.0025 0.008 0.006
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.015 0.015
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0044 0.0244 0.0224
Brugia malayi ecdysteroid receptor 0.0037 0.0184 0.0548
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0059
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0179 0.2654
Brugia malayi Serotonin receptor 0.0044 0.0244 0.0752
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0244 0.0224
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0148 0.0302
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.015 0.1953
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0191 0.0405
Brugia malayi hypothetical protein 0.0044 0.0244 0.0752
Schistosoma mansoni hypothetical protein 0.0024 0.0075 0.0075
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0104 0.3814
Toxoplasma gondii thioredoxin reductase 0.0038 0.0191 0.2754
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0025 0.008 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0179
Brugia malayi neuropeptide F receptor 0.0044 0.0244 0.0752
Brugia malayi hypothetical protein 0.0044 0.0244 0.0752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0244 0.0224
Onchocerca volvulus 0.0031 0.0137 0.0567
Schistosoma mansoni suppressor of cytokine signaling 0.0025 0.008 0.008
Schistosoma mansoni neuropeptide f receptor 76f 0.0044 0.0244 0.0244
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0184 0.0164
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0672 1
Echinococcus multilocularis allatostatin A receptor 0.0044 0.0244 0.0224
Brugia malayi FAD binding domain containing protein 0.0018 0.0028 0.0019
Mycobacterium tuberculosis Probable lipase LipD 0.0083 0.0561 0.1281
Trypanosoma brucei hypothetical protein, conserved 0.0083 0.0561 1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0113 0.0093
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0105 0.0739 0.2432
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0184 0.0548
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0191 0.0574
Echinococcus granulosus tyrosine protein kinase Fyn 0.0245 0.1899 0.1882
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0184 0.0184
Entamoeba histolytica SH2 domain containing protein 0.0025 0.008 0.0265
Schistosoma mansoni hypothetical protein 0.0048 0.0276 0.0276
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0195 0.0176
Entamoeba histolytica protein kinase, putative 0.0025 0.0087 0.0317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.015 0.015
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0025 0.008 0.006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.015 0.013
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0022 0.0002
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0361 0.0341
Echinococcus granulosus intermediate filament protein 0.0027 0.0098 0.0078
Trypanosoma brucei trypanothione reductase 0.0038 0.0191 0.2886
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0593 0.1356
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0029 0.012 0.1525
Onchocerca volvulus 0.0044 0.0244 0.1097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0184 0.0548
Brugia malayi hypothetical protein 0.0044 0.0244 0.0752
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0075 0.0179
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0031 0.0137 0.0654
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0044 0.0244 0.0224
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.0277 0.0864
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0244 0.0224
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0561 0.243
Brugia malayi Protein kinase domain containing protein 0.0031 0.0137 0.0388
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0179 0.2654
Loa Loa (eye worm) SH2 domain-containing protein 0.0025 0.008 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0075 0.0245
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0044 0.0244 0.0224
Schistosoma mansoni tyrosine kinase 0.0031 0.0137 0.0137
Schistosoma mansoni biogenic amine receptor 0.0044 0.0244 0.0244
Schistosoma mansoni ferritin 0.0017 0.002 0.002
Schistosoma mansoni tensin 0.0025 0.008 0.008
Brugia malayi FAD binding domain containing protein 0.0029 0.012 0.0334
Loa Loa (eye worm) SRC-1 0.0245 0.1899 0.6368
Echinococcus multilocularis expressed conserved protein 0.0099 0.0694 0.0675
Onchocerca volvulus 0.0263 0.204 1
Echinococcus multilocularis fmrfamide receptor 0.0044 0.0244 0.0224
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0184 0.0164
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0244 0.0244
Mycobacterium tuberculosis Probable reductase 0.0087 0.0593 0.1356
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0022 0.0002
Schistosoma mansoni ferritin 0.0017 0.002 0.002
Echinococcus granulosus SH2 motif 0.0025 0.008 0.006
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0029 0.012 0.01
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Schistosoma mansoni amine GPCR 0.0044 0.0244 0.0244
Brugia malayi Src substrate cortactin 0.0024 0.0075 0.0179
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.0231
Schistosoma mansoni hypothetical protein 0.1229 1 1
Brugia malayi Tensin 0.0025 0.008 0.0196
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0044 0.0244 0.0752
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0024 0.0075 0.0055
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0025 0.008 0.008
Schistosoma mansoni suppressor of cytokine signaling 0.0025 0.008 0.008
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.0244 0.0224
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0041 0.0041
Echinococcus granulosus src region 0.0024 0.0075 0.0055
Schistosoma mansoni GTPase activating protein 0.0025 0.008 0.008
Schistosoma mansoni glutaminase 0.0288 0.2247 0.2247
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus multilocularis protein patched 0.0045 0.0251 0.0231
Schistosoma mansoni opsin-like receptor 0.0044 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.0024 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0106 0.0747 0.2459
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0375 0.2969 0.2955
Echinococcus granulosus allatostatin A receptor 0.0044 0.0244 0.0224
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.0244 0.0224
Onchocerca volvulus 0.0083 0.0561 0.2671
Brugia malayi SRC-1 0.0245 0.1899 0.6368
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0184 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0075 0.0648
Brugia malayi SH2 domain containing protein 0.0025 0.008 0.0196
Onchocerca volvulus 0.0031 0.0137 0.0567
Mycobacterium ulcerans lipase LipD 0.0083 0.0561 0.243
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0051 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0244 0.0244
Echinococcus multilocularis G protein coupled receptor 139 0.0044 0.0244 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0184 0.0548
Loa Loa (eye worm) hypothetical protein 0.0037 0.0184 0.0548
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Schistosoma mansoni eps8-related protein 0.0024 0.0075 0.0075
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0104 0.1213
Entamoeba histolytica hypothetical protein, conserved 0.0024 0.0075 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0184 0.0548
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1424 0.1424
Schistosoma mansoni amine GPCR 0.0044 0.0244 0.0244
Brugia malayi SH2 domain containing protein 0.0025 0.008 0.0196
Loa Loa (eye worm) hypothetical protein 0.0083 0.0561 0.1829
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0184 0.0164
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.0244 0.0224
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0025 0.008 0.006
Loa Loa (eye worm) glutathione reductase 0.0038 0.0191 0.0574
Brugia malayi putative neuropeptide receptor 0.0044 0.0244 0.0752
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus multilocularis transfer RNA-Ala 0.0024 0.0075 0.0055
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0179 0.0714
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0276 0.0257
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0041 0.0094
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0044 0.0244 0.0244
Schistosoma mansoni nck2/grb4 0.0048 0.0277 0.0277
Echinococcus granulosus g protein coupled receptor 0.0044 0.0244 0.0224
Brugia malayi beta-lactamase 0.0083 0.0561 0.1829
Echinococcus multilocularis tyrosine protein kinase Abl 0.0055 0.0334 0.0314
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0361 0.6147
Brugia malayi protein-tyrosine kinase 0.0024 0.0075 0.0179
Schistosoma mansoni inositol monophosphatase 0.0037 0.0179 0.0179
Chlamydia trachomatis sulfite reductase 0.0018 0.0028 0.5
Brugia malayi hypothetical protein 0.0025 0.008 0.0196
Onchocerca volvulus 0.0025 0.008 0.0286
Trichomonas vaginalis penicillin-binding protein, putative 0.0083 0.0561 0.243
Echinococcus granulosus beta LACTamase domain containing family member 0.0083 0.0561 0.0542
Echinococcus granulosus orexin receptor type 2 0.0044 0.0244 0.0224
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0044 0.0244 0.0244
Onchocerca volvulus 0.0025 0.008 0.0286
Brugia malayi ORL1-like opioid receptor 0.0044 0.0244 0.0752
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus granulosus nostrin 0.0024 0.0075 0.0055
Schistosoma mansoni biogenic amine receptor 0.0044 0.0244 0.0244
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Leishmania major importin beta-1 subunit, putative 0.0023 0.0068 0.052
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0245 0.1899 0.1882
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0029 0.012 0.1525
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0025 0.008 0.008
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.002 0.5
Onchocerca volvulus 0.0044 0.0244 0.1097
Onchocerca volvulus 0.0044 0.0244 0.1097
Schistosoma mansoni hypothetical protein 0.0044 0.0244 0.0244
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0022 0.0022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0244 0.0244
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0593 0.1356
Schistosoma mansoni cell polarity protein 0.0024 0.0075 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0039 0.0039
Brugia malayi SH2 domain containing protein 0.0031 0.0137 0.0388
Schistosoma mansoni C-fyn 0.0024 0.0075 0.0075
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0041 0.0021
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0098 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0075 0.0245
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0184 0.0801
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Loa Loa (eye worm) SH2 domain-containing protein 0.0025 0.008 0.0196
Brugia malayi STAT protein, DNA binding domain containing protein 0.0025 0.008 0.0196
Brugia malayi hypothetical protein 0.0044 0.0244 0.0752
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0277 0.0864
Schistosoma mansoni tensin 0.0025 0.008 0.008
Brugia malayi tRNA modification GTPase TrmE family protein 0.0025 0.008 0.0196
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0113 0.1374
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0244 0.0224
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Brugia malayi Dopamine receptor protein 1 0.0044 0.0244 0.0752
Schistosoma mansoni DNA polymerase eta 0.002 0.0041 0.0041
Leishmania major hypothetical protein, conserved 0.0028 0.0104 0.1213
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0025 0.008 0.006
Echinococcus granulosus 7TM GPCR rhodopsin 0.0044 0.0244 0.0224
Echinococcus granulosus 7tm_1 domain containing protein 0.0044 0.0244 0.0224
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0044 0.0244 0.0752
Plasmodium vivax flavodoxin domain containing protein 0.0026 0.0093 0.0827
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0184 0.0548
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0184 0.0548
Loa Loa (eye worm) hypothetical protein 0.0033 0.015 0.0435
Echinococcus granulosus tyrosine protein kinase ABL1 0.0031 0.0137 0.0117
Brugia malayi Melatonin receptor type 1A 0.0044 0.0244 0.0752
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0245 0.1899 0.1882
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0025 0.008 0.0196
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0179
Schistosoma mansoni amine GPCR 0.0044 0.0244 0.0244
Echinococcus granulosus suppressor of cytokine signaling 7 0.0025 0.008 0.006
Onchocerca volvulus 0.0031 0.0137 0.0567
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0083 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0184 0.0548
Brugia malayi Myosin tail family protein 0.0024 0.0075 0.0179
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0184 0.0548
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0137 0.0388
Brugia malayi larval opioid receptor 0.0044 0.0244 0.0752
Echinococcus multilocularis dro:myosuppressin receptor 0.0044 0.0244 0.0224
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Echinococcus granulosus SH2 domain containing protein 7 0.0025 0.008 0.006
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0022 0.0002
Plasmodium vivax glutathione reductase, putative 0.0038 0.0191 0.2754
Brugia malayi nuclear receptor RXR 0.002 0.0039 0.0059
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0361 0.0361
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0025 0.008 0.006
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0041 0.0094
Brugia malayi follicle stimulating hormone receptor 0.0044 0.0244 0.0752
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0148 0.1952
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0277 0.0864
Brugia malayi G-protein coupled receptor 0.0044 0.0244 0.0752
Echinococcus granulosus tyrosine protein kinase Fyn 0.0245 0.1899 0.1882
Loa Loa (eye worm) hypothetical protein 0.0083 0.0561 0.1829
Onchocerca volvulus 0.0025 0.008 0.0286
Echinococcus multilocularis protein dispatched 1 0.0052 0.0303 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0184 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0075 0.0245
Brugia malayi Inositol-1 0.0037 0.0179 0.0533
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.0244 0.0224
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0179 0.0714
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0179 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0222 0.1702 0.1685
Onchocerca volvulus 0.0027 0.0098 0.0375
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0024 0.0075 0.0055
Echinococcus granulosus dna polymerase eta 0.002 0.0041 0.0021
Echinococcus granulosus N chimaerin 0.0025 0.008 0.006
Entamoeba histolytica protein kinase, putative 0.0024 0.0075 0.0231
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.1424 0.1406
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0044 0.0244 0.0244
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0044 0.0244 0.0224
Echinococcus granulosus G protein coupled receptor 139 0.0044 0.0244 0.0224
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0672 0.1545
Echinococcus multilocularis muscleblind protein 0.0152 0.113 0.1112
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.0244 0.0224
Brugia malayi hypothetical protein 0.0044 0.0244 0.0752
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.0231
Mycobacterium tuberculosis Conserved protein 0.0083 0.0561 0.1281
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0044 0.0244 0.1097
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0184 0.0184
Echinococcus multilocularis dna polymerase eta 0.002 0.0041 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0045 0.0251 0.0776
Echinococcus granulosus SH2 domain containing adapter protein F 0.0025 0.008 0.006
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0044 0.0244 0.0244
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0022 0.0002
Echinococcus granulosus intersectin 2 0.0024 0.0075 0.0055
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0245 0.1899 0.1882
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0041 0.0065
Brugia malayi Tyrosine-protein kinase abl-1 0.0055 0.0334 0.1057
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0018 0.0028 0.0028
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0184 0.0548
Schistosoma mansoni cytochrome P450 reductase 0.0029 0.012 0.012
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.0244 0.0224
Brugia malayi hypothetical protein 0.0018 0.0024 0.0006
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0245 0.1899 0.1882
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0179 0.2654
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.014 0.012
Brugia malayi protein-tyrosine kinase 0.0222 0.1702 0.5699
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0041 0.0094
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0276 0.0863
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0747 0.0728
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0025 0.008 0.0196
Echinococcus multilocularis growth factor receptor bound protein 2 0.0048 0.0277 0.0257
Onchocerca volvulus 0.0044 0.0244 0.1097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.1137 0.3784
Onchocerca volvulus 0.0027 0.0098 0.0375
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0051 0.1831
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0022 0.0002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0022 0.0002
Schistosoma mansoni lamin 0.0027 0.0098 0.0098
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0039 0.0059
Brugia malayi SH2 domain containing protein 0.0025 0.008 0.0196
Echinococcus multilocularis beta LACTamase domain containing family member 0.0083 0.0561 0.0542
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0068 0.0216
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.0277 0.0277
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0137 0.0388
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0244 0.0244
Schistosoma mansoni dynamin-associated protein 0.0024 0.0075 0.0075
Schistosoma mansoni adenoreceptor 0.0044 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Loa Loa (eye worm) thyroid receptor interactor 0.0024 0.0075 0.0179
Brugia malayi Sex muscle abnormal protein 5 0.0048 0.0277 0.0864
Brugia malayi Muscleblind-like protein 0.0152 0.113 0.3759
Echinococcus granulosus tyrosine protein kinase Blk 0.0222 0.1702 0.1685
Brugia malayi hypothetical protein 0.0044 0.0244 0.0752
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0184 0.0548
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0179 0.0714
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0044 0.0244 0.0752
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0024 0.0075 0.0179
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0075 0.0179
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0025 0.008 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.015 0.015
Echinococcus granulosus Niemann Pick C1 protein 0.0151 0.112 0.1102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.015 0.015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.1137 0.3784
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0024 0.0075 0.0055
Brugia malayi hypothetical protein 0.0031 0.0137 0.0388
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0132 0.0132
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0044 0.0244 0.0244
Echinococcus granulosus Spectrin alpha actinin 0.0024 0.0075 0.0055
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0024 0.0075 0.0055
Schistosoma mansoni growth hormone secretagogue receptor 0.0044 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Echinococcus multilocularis Spectrin alpha actinin 0.0024 0.0075 0.0055
Echinococcus granulosus importin subunit beta 1 0.0029 0.0113 0.0093
Schistosoma mansoni tyrosine kinase 0.0055 0.0334 0.0334
Echinococcus multilocularis SH2 domain containing protein 7 0.0025 0.008 0.006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0083 0.0561 0.1829
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0561 0.243
Echinococcus granulosus serotonin receptor 0.0044 0.0244 0.0224
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0184 0.0164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0244 0.0244
Onchocerca volvulus 0.0044 0.0244 0.1097
Plasmodium falciparum glutathione reductase 0.0038 0.0191 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0025 0.008 0.008
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0044 0.0244 0.0224
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0361 0.6075
Echinococcus granulosus SHC transforming protein 3 0.0025 0.008 0.006
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.0231
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0044 0.0244 0.0244
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0184 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0075 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0184 0.0548
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Schistosoma mansoni hypothetical protein 0.0304 0.2384 0.2384
Echinococcus multilocularis fmrfamide receptor 0.0044 0.0244 0.0224
Mycobacterium leprae conserved hypothetical protein 0.0083 0.0561 0.8292
Entamoeba histolytica protein kinase, putative 0.0197 0.15 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0024 0.0075 0.0179
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0276 0.0863
Echinococcus multilocularis expressed protein 0.0024 0.0075 0.0055
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0024 0.0075 0.0055
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0025 0.008 0.006
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0184 0.0184
Mycobacterium tuberculosis Conserved protein 0.0083 0.0561 0.1281
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0024 0.0075 0.0075
Echinococcus multilocularis muscleblind protein 1 0.0152 0.113 0.1112
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0361 0.0341
Echinococcus granulosus tyrosine protein kinase Src42A 0.0215 0.1645 0.1628
Schistosoma mansoni hypothetical protein 0.0105 0.0739 0.0739
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Echinococcus granulosus tyrosine protein kinase Src42A 0.0245 0.1899 0.1882
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0044 0.0244 0.0752
Echinococcus multilocularis GPCR, family 2 0.0048 0.0276 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0184 0.0548
Loa Loa (eye worm) hypothetical protein 0.0092 0.0634 0.2078
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0245 0.1899 0.1882
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0022 0.0002
Echinococcus multilocularis orexin receptor type 2 0.0044 0.0244 0.0224
Echinococcus granulosus neuropeptide s receptor 0.0491 0.392 0.3908
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0044 0.0244 0.0244
Brugia malayi nuclear receptor NHR-88 0.0037 0.0184 0.0548
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.0244 0.0244
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0375 0.2969 0.2955
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0747 0.0728
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0029 0.012 0.1525
Loa Loa (eye worm) hypothetical protein 0.0152 0.113 0.3759
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0251 0.0231
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0179 0.0946
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0025 0.0087 0.0317
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.1778 0.5957
Schistosoma mansoni tensin-related 0.0025 0.008 0.008
Giardia lamblia Hypothetical protein 0.0026 0.0093 1
Brugia malayi G-protein coupled receptor 0.0044 0.0244 0.0752
Brugia malayi hypothetical protein 0.0028 0.0104 0.0279
Schistosoma mansoni hypothetical protein 0.0044 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0083 0.0561 0.1829
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0024 0.0075 0.0075
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0184 0.0164
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0137 0.0388
Echinococcus granulosus hypothetical protein 0.0025 0.008 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.1137 0.3784
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1424 0.1424
Echinococcus granulosus peptide allatostatin:somatostatin 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus granulosus tyrosine protein kinase Srms 0.0031 0.0137 0.0117
Onchocerca volvulus 0.0044 0.0244 0.1097
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0113 0.1214
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0152 0.113 0.3759
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.1424 0.4756
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0025 0.008 0.006
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0025 0.008 0.0196
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0022 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0361 0.0361
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0179 0.0159
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0179 0.2517
Brugia malayi Importin beta-1 subunit 0.0029 0.0113 0.0307
Brugia malayi SH2 domain containing protein 0.0025 0.008 0.0196
Brugia malayi beta-lactamase family protein 0.0083 0.0561 0.1829
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Brugia malayi flavodoxin family protein 0.0029 0.012 0.0334
Trichomonas vaginalis ran, putative 0.0021 0.0051 0.0137
Entamoeba histolytica Ran family GTPase 0.0021 0.0051 0.0065
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.2384 0.8015
Loa Loa (eye worm) hypothetical protein 0.0048 0.0277 0.0864
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0044 0.0244 0.0224
Echinococcus granulosus GPCR family 2 0.0048 0.0276 0.0257
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Schistosoma mansoni amine GPCR 0.0044 0.0244 0.0244
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus multilocularis tyrosine protein kinase Blk 0.0222 0.1702 0.1685
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0075 0.0245
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0068 0.0216
Schistosoma mansoni hypothetical protein 0.0044 0.0237 0.0237
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0022 0.0002
Schistosoma mansoni eyes absent homolog 0.0092 0.0634 0.0634
Brugia malayi AKH receptor 0.0044 0.0244 0.0752
Brugia malayi hypothetical protein 0.0044 0.0244 0.0752
Schistosoma mansoni importin beta-1 0.0029 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0037 0.0184 0.0548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0184 0.0548
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0251 0.0231
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0039 0.0059
Echinococcus granulosus expressed conserved protein 0.0099 0.0694 0.0675
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0215 0.1645 0.1628
Echinococcus granulosus dna polymerase kappa 0.002 0.0041 0.0021
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0184 0.0548
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0031 0.0137 0.0117
Loa Loa (eye worm) hypothetical protein 0.0055 0.0335 0.1061
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0059
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0137 0.0388
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0184 0.0548
Onchocerca volvulus 0.0025 0.008 0.0286
Echinococcus multilocularis sex peptide receptor 0.0044 0.0244 0.0224
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0025 0.008 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0137 0.0388
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0184 0.0548
Trichomonas vaginalis glutaminase, putative 0.0288 0.2247 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0184 0.0184
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0024 0.0075 0.0055
Onchocerca volvulus 0.0024 0.0075 0.0261
Echinococcus multilocularis tyrosine protein kinase Srms 0.0222 0.1702 0.1685
Loa Loa (eye worm) hypothetical protein 0.0037 0.0184 0.0548
Brugia malayi Serine/threonine-protein kinase SULU 0.0375 0.2969 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0184 0.0164
Schistosoma mansoni coup transcription factor 0.0037 0.0184 0.0184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Toxoplasma gondii ABC1 family protein 0.0083 0.0561 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0672 0.1545
Echinococcus multilocularis neuropeptide receptor 0.0044 0.0244 0.0224
Onchocerca volvulus 0.0024 0.0075 0.0261
Echinococcus granulosus somatostatin receptor 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus multilocularis neuropeptide receptor 0.0044 0.0244 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0184 0.0548
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0195 0.0176
Echinococcus multilocularis tyrosine protein kinase shark 0.0031 0.0137 0.0117
Brugia malayi GnHR receptor homolog 0.0044 0.0244 0.0752
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0051 0.003
Echinococcus granulosus lamin 0.0027 0.0098 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0137 0.0388
Echinococcus multilocularis tensin 0.0025 0.008 0.006
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0022 0.0022
Brugia malayi Guanylate kinase family protein 0.0024 0.0075 0.0179
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0083 0.0561 0.1281
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0251 0.0776
Onchocerca volvulus 0.0031 0.0137 0.0567
Schistosoma mansoni adapter molecule crk 0.0048 0.0277 0.0277
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0222 0.1702 0.1685
Echinococcus granulosus tachykinin peptides receptor 99D 0.0044 0.0244 0.0224
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0024 0.0075 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0075 0.0648
Loa Loa (eye worm) TK protein kinase 0.0222 0.1702 0.5699
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0196
Brugia malayi G protein-coupled receptor F59B2.13 0.0044 0.0244 0.0752
Schistosoma mansoni opsin-like receptor 0.0044 0.0244 0.0244
Onchocerca volvulus 0.0031 0.0137 0.0567
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.0231
Schistosoma mansoni nuclear receptor 0.0018 0.0022 0.0022
Brugia malayi hypothetical protein 0.0044 0.0244 0.0752
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.0747 0.4839
Schistosoma mansoni lamin 0.0027 0.0098 0.0098
Schistosoma mansoni shc transforming protein 0.0025 0.008 0.008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0245 0.1899 0.1882
Schistosoma mansoni Dab2-interacting protein-like 0.0024 0.0075 0.0075
Echinococcus multilocularis signal transduction protein lnk realted 0.0025 0.008 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1424 0.1424
Schistosoma mansoni run and tbc1 domain containing 0.0024 0.0075 0.0075
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0245 0.1899 0.1882
Schistosoma mansoni opsin-like receptor 0.0044 0.0244 0.0244
Leishmania major GTP-binding protein, putative 0.0021 0.0051 0.0182
Schistosoma mansoni apoferritin-2 0.0017 0.002 0.002
Schistosoma mansoni amine GPCR 0.0044 0.0244 0.0244
Loa Loa (eye worm) protein-tyrosine kinase 0.0024 0.0075 0.0179
Echinococcus granulosus g protein coupled receptor 0.0044 0.0244 0.0224
Loa Loa (eye worm) FAD binding domain-containing protein 0.0029 0.012 0.0334
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0179
Schistosoma mansoni apoferritin-2 0.0017 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0048 0.0276 0.0863
Onchocerca volvulus 0.0025 0.008 0.0286
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.0231
Trichomonas vaginalis set domain proteins, putative 0.0263 0.204 0.9073
Mycobacterium tuberculosis Conserved protein 0.0083 0.0561 0.1281
Brugia malayi Tachykinin-like peptides receptor 99D 0.0044 0.0244 0.0752
Trichomonas vaginalis p67phox protein, putative 0.0024 0.0075 0.0245
Brugia malayi intermediate filament protein 0.0027 0.0098 0.0257
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0276 0.0257
Echinococcus granulosus fch and double sh3 domains protein 2 0.0024 0.0075 0.0055
Schistosoma mansoni dreadlocks/dock 0.0024 0.0075 0.0075
Mycobacterium leprae Probable lipase LipE 0.0083 0.0561 0.8292
Echinococcus granulosus tensin 0.0025 0.008 0.006
Echinococcus granulosus endophilin A3 0.0024 0.0075 0.0055
Schistosoma mansoni zinc finger protein 0.0018 0.0022 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.0083 0.0561 0.1281
Schistosoma mansoni formin binding protein and related proteins 0.0024 0.0075 0.0075
Entamoeba histolytica hypothetical protein 0.0023 0.0068 0.0185
Echinococcus multilocularis methionine synthase reductase 0.0018 0.0028 0.0007
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.0747 0.2459
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0307
Loa Loa (eye worm) TYRA-2 protein 0.0044 0.0244 0.0752
Onchocerca volvulus 0.0024 0.0075 0.0261
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0184 0.0548
Leishmania major p450 reductase, putative 0.0029 0.012 0.1525
Echinococcus granulosus NCK adaptor protein 0.0048 0.0277 0.0257
Echinococcus granulosus tyrosine protein kinase HCK 0.0197 0.15 0.1482
Brugia malayi Dopamine receptor protein 2 0.0044 0.0244 0.0752
Leishmania major hypothetical protein, conserved 0.0083 0.0561 1
Schistosoma mansoni hypothetical protein 0.0025 0.008 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0244 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0184 0.0548
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0361 0.153
Onchocerca volvulus 0.0044 0.0244 0.1097
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0184 0.0184
Schistosoma mansoni tyrosine kinase 0.0245 0.1899 0.1899
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus granulosus signal transduction protein lnk realted 0.0025 0.008 0.006
Brugia malayi Serotonin receptor 0.0044 0.0244 0.0752
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0075 0.0245
Echinococcus granulosus tyrosine protein kinase shark 0.0031 0.0137 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0244 0.0244
Schistosoma mansoni tensin 0.0025 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0179
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.076 0.076
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0025 0.008 0.0196
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0059
Brugia malayi glutaminase DH11.1 0.0288 0.2247 0.7548
Echinococcus multilocularis NCK adaptor protein 0.0048 0.0277 0.0257
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0104 0.1213
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0044 0.0244 0.0752
Echinococcus multilocularis SH2 motif 0.0025 0.008 0.006
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0024 0.0075 0.0261
Schistosoma mansoni serine/threonine protein kinase 0.0375 0.2969 0.2969
Brugia malayi CHE-14 protein 0.0045 0.0251 0.0776
Onchocerca volvulus 0.0083 0.0561 0.2671
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0245 0.1899 0.1882
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0029 0.012 0.1368
Onchocerca volvulus 0.0044 0.0244 0.1097
Schistosoma mansoni hypothetical protein 0.0048 0.0276 0.0276
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0083 0.0561 0.243
Mycobacterium ulcerans glutaminase 0.0288 0.2247 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Brugia malayi G protein-coupled receptor 0.0044 0.0244 0.0752
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0022 0.0002
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0044 0.0244 0.0244
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0083 0.0561 0.1829
Schistosoma mansoni sorting nexin 0.0024 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Leishmania major cytochrome P450 reductase, putative 0.0026 0.0093 0.0994
Echinococcus multilocularis lamin dm0 0.0027 0.0098 0.0078
Echinococcus granulosus epidermal growth factor receptor kinase 0.0024 0.0075 0.0055
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0184 0.0164
Schistosoma mansoni inositol monophosphatase 0.0037 0.0179 0.0179
Mycobacterium tuberculosis Possible penicillin-binding protein 0.053 0.4244 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0044 0.0244 0.0224
Schistosoma mansoni neuropeptide receptor 0.0044 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.0044 0.0244 0.0244
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0044 0.0244 0.0224
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0104 0.1051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0083 0.0561 0.0561
Echinococcus granulosus neuropeptide receptor 0.0044 0.0244 0.0224
Echinococcus multilocularis G-protein coupled receptor, putative 0.0044 0.0244 0.0224
Trypanosoma brucei conserved protein 0.0024 0.0075 0.0648
Brugia malayi sulfakinin receptor protein 0.0044 0.0244 0.0752
Schistosoma mansoni ferritin light chain 0.0017 0.002 0.002
Schistosoma mansoni neuropeptide receptor 0.0044 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Loa Loa (eye worm) glutaminase 2 0.0288 0.2247 0.7548
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0025 0.008 0.006
Schistosoma mansoni ferritin 0.0017 0.002 0.002
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0179 0.0714
Echinococcus granulosus tyrosine kinase 0.0222 0.1702 0.1685
Echinococcus multilocularis Niemann Pick C1 protein 0.0151 0.112 0.1102
Leishmania major hypothetical protein, conserved 0.0024 0.0075 0.0648
Brugia malayi SH2 domain containing protein 0.0025 0.008 0.0196
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0184 0.0164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0244 0.0244
Echinococcus multilocularis endophilin A3 0.0024 0.0075 0.0055
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0276 0.0257
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0075 0.0179
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0025 0.008 0.006
Echinococcus multilocularis serotonin receptor 0.0044 0.0244 0.0224
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.015 0.013
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0025 0.008 0.0286
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0051 0.0182
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0113 0.1374
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0083 0.0561 0.1281
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0059
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0334
Echinococcus multilocularis 0.0025 0.008 0.006
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0039 0.0039
Brugia malayi Thioredoxin reductase 0.0038 0.0191 0.0574
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0048 0.0277 0.0277
Echinococcus multilocularis neuropeptide FF receptor 2 0.0044 0.0244 0.0224
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0022 0.0002
Onchocerca volvulus 0.0025 0.0082 0.0299
Schistosoma mansoni SH2A 0.0025 0.008 0.008
Mycobacterium ulcerans hypothetical protein 0.0083 0.0561 0.243
Brugia malayi hypothetical protein 0.0375 0.2969 1
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.0244 0.0224
Brugia malayi SH3 domain containing protein 0.0024 0.0075 0.0179
Loa Loa (eye worm) STAT protein 0.0025 0.008 0.0196
Echinococcus granulosus muscleblind protein 0.0152 0.113 0.1112
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0025 0.008 0.0286
Onchocerca volvulus 0.0083 0.0561 0.2671
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0059
Brugia malayi hypothetical protein 0.002 0.0039 0.0059
Schistosoma mansoni biogenic amine receptor 0.0044 0.0244 0.0244
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0039 0.0019
Brugia malayi hypothetical protein 0.0044 0.0244 0.0752
Leishmania major trypanothione reductase 0.0038 0.0191 0.2886
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0184 0.0164
Echinococcus multilocularis c src tyrosine kinase 0.0055 0.0334 0.0314
Brugia malayi SH2 domain containing protein 0.0025 0.008 0.0196
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0024 0.0075 0.0055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0184 0.0164
Echinococcus granulosus g protein coupled receptor 0.0044 0.0244 0.0224
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.0048 0.0276 0.0276
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0029 0.012 0.1525
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0244 0.0244
Schistosoma mansoni neuropeptide receptor 0.0044 0.0244 0.0244
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.1424 0.1406
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0276 0.0863
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0044 0.0244 0.0752
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0593 0.8777
Schistosoma mansoni signal transduction protein lnk-related 0.0025 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0561 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0245 0.1899 0.1882
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0029 0.012 0.1525
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0184 0.0164
Onchocerca volvulus 0.0024 0.0075 0.0261
Schistosoma mansoni ferritin 0.0017 0.002 0.002
Brugia malayi nuclear hormone receptor 0.0037 0.0184 0.0548
Schistosoma mansoni apoptosis stimulating of P53 0.0024 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0048 0.0276 0.0276
Echinococcus granulosus tyrosine kinase 0.0031 0.0137 0.0117
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0051 0.0182
Loa Loa (eye worm) p53BP2 0.0024 0.0075 0.0179
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus multilocularis nostrin 0.0024 0.0075 0.0055
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0041 0.0094
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0184 0.0164
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Echinococcus granulosus neuropeptide receptor 0.0044 0.0244 0.0224
Loa Loa (eye worm) hypothetical protein 0.0037 0.0184 0.0548
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0025 0.008 0.006
Brugia malayi Dopamine receptor 0.0044 0.0244 0.0752
Brugia malayi hypothetical protein 0.0092 0.0634 0.2078
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0029 0.012 0.045
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0825 0.6674 0.6668
Echinococcus multilocularis SHC transforming protein 3 0.0025 0.008 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0244 0.0224
Schistosoma mansoni tensin-related 0.0025 0.008 0.008
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0184 0.0548
Loa Loa (eye worm) hypothetical protein 0.0044 0.0244 0.0752
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0065
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0137 0.0388

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 36.2 nM Inhibition of estradiol-stimulated T-47D cell proliferation. ChEMBL. 9216828
IC50 (functional) = 36.2 nM Inhibition of estradiol-stimulated T-47D cell proliferation. ChEMBL. 9216828
Ki (functional) = 4.22 nM Apparent binding affinity against estradiol-stimulated T-47D cell proliferation ChEMBL. 9216828
Ki (functional) = 4.22 nM Apparent binding affinity against estradiol-stimulated T-47D cell proliferation ChEMBL. 9216828
Ki (binding) > 270 nM Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) ChEMBL. 9216828
Ki (binding) > 270 nM Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) ChEMBL. 9216828
RBA (binding) < 0.04 Relative Binding Affinity for estrogen receptor in Human Breast cancer or normal uterine cytosol in 3.3%ethanol compared to estradiol ChEMBL. 9216828
Weight (functional) = 15.7 mg Uterine weight after 9 day treatment at 16 ug by oral gavage to ovariectomised mice without estrone ChEMBL. 9216828
Weight (functional) = 15.7 mg Uterine weight after 9 day treatment at 16 ug by oral gavage to ovariectomised mice without estrone ChEMBL. 9216828
Weight (functional) = 16.5 mg Uterine weight after 9 day treatment at 0.47 ug by oral gavage to ovariectomised mice without estrone ChEMBL. 9216828
Weight (functional) = 16.5 mg Uterine weight after 9 day treatment at 0.47 ug by oral gavage to ovariectomised mice without estrone ChEMBL. 9216828
Weight (functional) = 17.2 mg Uterine weight after 9 day treatment at 1.6 ug by oral gavage to ovariectomised mice without estrone ChEMBL. 9216828
Weight (functional) = 17.2 mg Uterine weight after 9 day treatment at 1.6 ug by oral gavage to ovariectomised mice without estrone ChEMBL. 9216828
Weight (functional) = 18 mg Uterine weight after 9 day treatment at 47 ug by oral gavage to ovariectomised mice without estrone ChEMBL. 9216828
Weight (functional) = 18 mg Uterine weight after 9 day treatment at 47 ug by oral gavage to ovariectomised mice without estrone ChEMBL. 9216828
Weight (functional) = 19.8 mg Uterine weight after 9 day treatment at 4.7 ug by oral gavage to ovariectomised mice without estrone ChEMBL. 9216828
Weight (functional) = 19.8 mg Uterine weight after 9 day treatment at 4.7 ug by oral gavage to ovariectomised mice without estrone ChEMBL. 9216828
Weight (functional) = 61.1 mg Uterine weight after 9 day treatment at 47 ug by oral gavage to ovariectomised mice with estrone ChEMBL. 9216828
Weight (functional) = 61.1 mg Uterine weight after 9 day treatment at 47 ug by oral gavage to ovariectomised mice with estrone ChEMBL. 9216828
Weight (functional) = 75.7 mg Uterine weight after 9 day treatment at 16 ug by oral gavage to ovariectomised mice with estrone ChEMBL. 9216828
Weight (functional) = 75.7 mg Uterine weight after 9 day treatment at 16 ug by oral gavage to ovariectomised mice with estrone ChEMBL. 9216828
Weight (functional) = 83.1 mg Uterine weight after 9 day treatment at 0.47 ug by oral gavage to ovariectomised mice with estrone ChEMBL. 9216828
Weight (functional) = 83.1 mg Uterine weight after 9 day treatment at 0.47 ug by oral gavage to ovariectomised mice with estrone ChEMBL. 9216828
Weight (functional) = 88.6 mg Uterine weight after 9 day treatment at 1.6 ug by oral gavage to ovariectomised mice with estrone ChEMBL. 9216828
Weight (functional) = 88.6 mg Uterine weight after 9 day treatment at 1.6 ug by oral gavage to ovariectomised mice with estrone ChEMBL. 9216828
Weight (functional) = 91.2 mg Uterine weight after 9 day treatment at 4.7 ug by oral gavage to ovariectomised mice with estrone ChEMBL. 9216828
Weight (functional) = 91.2 mg Uterine weight after 9 day treatment at 4.7 ug by oral gavage to ovariectomised mice with estrone ChEMBL. 9216828

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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