Detailed information for compound 1087237

Basic information

Technical information
  • TDR Targets ID: 1087237
  • Name: 3-(5-bromo-4-methyl-1,3-thiazol-2-yl)-1-[3-(d ifluoromethoxy)phenyl]sulfonylurea
  • MW: 442.256 | Formula: C12H10BrF2N3O4S2
  • H donors: 2 H acceptors: 4 LogP: 4.32 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NS(=O)(=O)c1cccc(c1)OC(F)F)Nc1nc(c(s1)Br)C
  • InChi: 1S/C12H10BrF2N3O4S2/c1-6-9(13)23-12(16-6)17-11(19)18-24(20,21)8-4-2-3-7(5-8)22-10(14)15/h2-5,10H,1H3,(H2,16,17,18,19)
  • InChiKey: DXBZEWFGCOOOEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(5-bromo-4-methyl-thiazol-2-yl)-1-[3-(difluoromethoxy)phenyl]sulfonyl-urea
  • 3-(5-bromo-4-methyl-2-thiazolyl)-1-[3-(difluoromethoxy)phenyl]sulfonylurea
  • 3-(5-bromo-4-methyl-1,3-thiazol-2-yl)-1-[3-(difluoromethoxy)phenyl]sulfonyl-urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fructose-1,6-bisphosphatase 1 Starlite/ChEMBL References
Mus musculus fructose bisphosphatase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Schistosoma mansoni fructose-16-bisphosphatase-related Get druggable targets OG5_127400 All targets in OG5_127400
Schistosoma japonicum ko:K03841 fructose-1,6-bisphosphatase I, putative Get druggable targets OG5_127400 All targets in OG5_127400
Loa Loa (eye worm) fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Echinococcus granulosus fructose 16 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Candida albicans similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania major Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania mexicana fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Neospora caninum Fructose-1 6-biphosphatase, related Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei gambiense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma congolense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania donovani fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Toxoplasma gondii fructose-bisphospatase II Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania braziliensis fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania infantum fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii fructose-bisphospatase I fructose-1,6-bisphosphatase 1 338 aa 326 aa 31.0 %
Toxoplasma gondii fructose-bisphospatase I fructose bisphosphatase 1 338 aa 326 aa 29.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lamin 0.0028 0.0121 0.0121
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0092 0.0092
Echinococcus multilocularis lamin dm0 0.0028 0.0121 0.0121
Onchocerca volvulus 0.0114 0.0925 0.1943
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0035 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0158 0.0379
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0191 0.1648 0.1648
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0217 0.2505
Mycobacterium ulcerans hypothetical protein 0.0114 0.0925 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0158 0.0158
Leishmania major importin beta-1 subunit, putative 0.0047 0.0303 0.0842
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0477 0.0477
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0459 0.4165 0.7304
Schistosoma mansoni hypothetical protein 0.0047 0.0299 0.0299
Onchocerca volvulus 0.0522 0.476 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.2109 0.2109
Schistosoma mansoni importin beta-1 0.0058 0.0406 0.0406
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.0925 0.1881
Echinococcus multilocularis peregrin 0.0061 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0309 0.2762 0.4844
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0037 0.0059
Leishmania major DNA polymerase eta, putative 0.0019 0.0036 0.0056
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0262 0.0262
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0085 0.0653 0.0653
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0158 0.0158
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0036 0.0036
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.052 0.052
Toxoplasma gondii fructose-bisphospatase II 0.0378 0.3406 1
Brugia malayi fructose-1,6-bisphosphatase 0.0378 0.3406 0.8178
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0158 0.0158
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0477 0.1309
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.0925 0.1881
Brugia malayi PHD-finger family protein 0.0058 0.0405 0.0973
Schistosoma mansoni hypothetical protein 0.1081 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0406 0.0713
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0121 0.0291
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.012 0.0303
Loa Loa (eye worm) hypothetical protein 0.0045 0.0281 0.0493
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0158 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0158 0.0277
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0158 0.0158
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0756 0.1524
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0158 0.0379
Mycobacterium leprae conserved hypothetical protein 0.0114 0.0925 0.5
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0035 0.0035
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0213 0.0213
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0231 0.0231
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0141 0.1178 0.339
Loa Loa (eye worm) hypothetical protein 0.01 0.0795 0.1395
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.0925 0.134
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.0925 0.2677
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0277
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0158 0.0158
Leishmania major DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0056
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.008 0.0192
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0036 0.0087
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0756 0.0756
Schistosoma mansoni hypothetical protein 0.0058 0.0405 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0158 0.0379
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0299 0.0524
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0756 0.1524
Echinococcus multilocularis expressed conserved protein 0.0092 0.0724 0.0724
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0299 0.0299
Brugia malayi GH02984p 0.0342 0.3071 0.7373
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0925 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0158 0.0158
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0035 0.0062
Schistosoma mansoni DNA polymerase eta 0.0019 0.0036 0.0036
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0405 0.1097
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0036 0.0036
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0405 0.1097
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0017 0.0041
Brugia malayi beta-lactamase 0.0114 0.0925 0.222
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0217 0.0382
Echinococcus multilocularis solute carrier family 5 0.0038 0.0213 0.0213
Schistosoma mansoni lamin 0.0028 0.0121 0.0121
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0262 0.0721
Onchocerca volvulus 0.0066 0.0477 0.1001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0406 0.0406
Plasmodium falciparum importin beta, putative 0.0058 0.0406 1
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0378 0.3406 0.3406
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0254 0.0461
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0055 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0477 0.0477
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1175 0.1175
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0299 0.0299
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0262 0.0629
Schistosoma mansoni patched 1 0.0042 0.0254 0.0254
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.054 0.054
Brugia malayi intermediate filament protein 0.0028 0.0121 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0158 0.0379
Echinococcus granulosus expressed conserved protein 0.0092 0.0724 0.0724
Loa Loa (eye worm) hypothetical protein 0.0114 0.0925 0.1622
Echinococcus granulosus solute carrier family 5 0.0038 0.0213 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0756 0.1524
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0925 0.1881
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0405 0.0405
Brugia malayi PHD-finger family protein 0.0021 0.0057 0.0138
Onchocerca volvulus 0.0114 0.0925 0.1943
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0036 0.0036
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0477 0.0477
Plasmodium vivax importin-beta 2, putative 0.0058 0.0406 0.4171
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0217 0.0217
Schistosoma mansoni zinc finger protein 0.0017 0.0017 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.0925 0.0925
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0213 0.0213
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0085 0.0653 0.0653
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0017 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.0925 0.222
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0756 0.1524
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0217 0.052
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0756 0.1816
Echinococcus multilocularis protein patched 0.0042 0.0254 0.0254
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0623 0.5702 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.0925 0.0925
Echinococcus multilocularis geminin 0.1081 1 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0092 0.0092
Onchocerca volvulus 0.0028 0.0121 0.0255
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.0925 0.1622
Echinococcus granulosus snurportin 1 0.0623 0.5702 0.5702
Trichomonas vaginalis set domain proteins, putative 0.0522 0.476 1
Echinococcus granulosus peregrin 0.0061 0.043 0.043
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0378 0.3406 0.3406
Onchocerca volvulus 0.0032 0.0158 0.0332
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0277
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0477 0.0477
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0017 0.0041
Brugia malayi jmjC domain containing protein 0.0019 0.0035 0.0085
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.0925 0.0925
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0158 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0158 0.0379
Loa Loa (eye worm) hypothetical protein 0.0042 0.0256 0.045
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0158 0.0379
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0148 0.1249 0.219
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0277
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0277
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.0925 0.134
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0303 0.0564
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0213 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0158 0.0379
Echinococcus multilocularis dna polymerase eta 0.0019 0.0036 0.0036
Brugia malayi steroid hormone receptor 0.0032 0.0158 0.0379
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0217 0.0588
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0213 0.0213
Leishmania major hypothetical protein, conserved 0.0019 0.0035 0.0053
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0217 0.038
Schistosoma mansoni lamin 0.0028 0.0121 0.0121
Schistosoma mansoni bromodomain containing protein 0.007 0.0514 0.0514
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0037 0.0025
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0158 0.0277
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.012 0.0303
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.0925 1
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0158 0.0158
Schistosoma mansoni ap endonuclease 0.0038 0.0217 0.0217
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0121 0.0212
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0254 0.0254
Brugia malayi RNA, U transporter 1 0.0166 0.1415 0.3398
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0211
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0036 0.0087
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.054 0.0947
Mycobacterium tuberculosis Conserved protein 0.0114 0.0925 0.134
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.1249 0.2998
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.0925 0.134
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Toxoplasma gondii ABC1 family protein 0.0114 0.0925 0.2639
Brugia malayi nuclear hormone receptor 0.0032 0.0158 0.0379
Schistosoma mansoni inositol transporter 0.0038 0.0213 0.0213
Brugia malayi jmjC domain containing protein 0.0019 0.0035 0.0085
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0158 0.0332
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0213 0.0213
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0042 0.0074
Schistosoma mansoni ran 0.0043 0.0262 0.0262
Leishmania major GTP-binding protein, putative 0.0043 0.0262 0.0721
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0141 0.1178 0.3425
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0405 0.0405
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0158 0.0277
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0217 0.4892
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0213 0.0213
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0454 0.0454
Brugia malayi Pre-SET motif family protein 0.0066 0.0477 0.1144
Schistosoma mansoni high-affinity choline transporter 0.0342 0.3071 0.3071
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0619 0.0619
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0158 0.0277
Loa Loa (eye worm) hypothetical protein 0.0058 0.0405 0.0711
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0303 0.0564
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0141 0.1178 0.3425
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.012 0.0252
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0158 0.0158
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0756 0.1327
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0217 0.0588
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0158 0.0158
Echinococcus multilocularis zinc finger protein 0.0022 0.0062 0.0062
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0158 0.0158
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0035 0.0035
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0756 0.2181
Loa Loa (eye worm) hypothetical protein 0.0114 0.0925 0.1622
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.2109 0.2109
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0217 0.0588
Schistosoma mansoni coup transcription factor 0.0032 0.0158 0.0158
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0158 0.0158
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.2109 0.2109
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0037 0.0007
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0017 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Brugia malayi hypothetical protein 0.0018 0.0028 0.0066
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0794 0.0794
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0158 0.0379
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0036 0.0064
Plasmodium vivax SET domain protein, putative 0.0066 0.0477 0.4961
Brugia malayi Bromodomain containing protein 0.0042 0.0256 0.0614
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0217 0.0217
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0114 0.0925 0.1622
Trichomonas vaginalis ran, putative 0.0043 0.0262 0.0477
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0756 0.1589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.2109 0.2109
Brugia malayi Muscleblind-like protein 0.0309 0.2762 0.6632
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Brugia malayi Bromodomain containing protein 0.0083 0.0636 0.1527
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.006 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0158 0.0277
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.003
Schistosoma mansoni hypothetical protein 0.0041 0.024 0.024
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0405 0.0405
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0925 0.1881
Brugia malayi Pre-SET motif family protein 0.0459 0.4165 1
Brugia malayi jmjC domain containing protein 0.0191 0.1648 0.3957
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.003
Schistosoma mansoni hypothetical protein 0.1081 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0262 0.0459
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0158 0.0158
Mycobacterium tuberculosis Conserved protein 0.0114 0.0925 0.134
Schistosoma mansoni inositol transporter 0.0038 0.0213 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Brugia malayi hypothetical protein 0.0028 0.012 0.0288
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.0925 0.134
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0217 0.0588
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0158 0.0158
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0262 0.6105
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.099 0.1736
Echinococcus multilocularis snurportin 1 0.0623 0.5702 0.5702
Loa Loa (eye worm) hypothetical protein 0.0309 0.2762 0.4844
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0405 0.0711
Echinococcus granulosus importin subunit beta 1 0.0058 0.0406 0.0406
Schistosoma mansoni jumonji domain containing protein 0.0151 0.128 0.128
Schistosoma mansoni intermediate filament proteins 0.0028 0.0121 0.0121
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0299 0.0299
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0036 0.0036
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0406 0.1147
Echinococcus granulosus histone lysine methyltransferase setb 0.0085 0.0653 0.0653
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0158 0.0379
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.084 0.7743 0.7743
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0299 0.0717
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0064
Echinococcus multilocularis muscleblind protein 0.0309 0.2762 0.2762
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.2109 0.2109
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0158 0.0379
Loa Loa (eye worm) hypothetical protein 0.0028 0.0121 0.0212
Loa Loa (eye worm) hypothetical protein 0.0085 0.0653 0.1146
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0035 0.0035
Trypanosoma brucei unspecified product 0.0019 0.0036 0.0056
Schistosoma mansoni hypothetical protein 0.0017 0.0017 0.0017
Echinococcus multilocularis musashi 0.0028 0.0121 0.0121
Leishmania major hypothetical protein, conserved 0.0028 0.012 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0158 0.0379
Schistosoma mansoni hypothetical protein 0.0023 0.0073 0.0073
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0158 0.0332
Schistosoma mansoni hypothetical protein 0.0101 0.0809 0.0809
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.054 0.054
Echinococcus multilocularis high affinity choline transporter 1 0.0342 0.3071 0.3071
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0055 0.0055
Brugia malayi hypothetical protein 0.0017 0.0017 0.0041
Echinococcus granulosus phd:f box containing protein 0.0019 0.0035 0.0035
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0756 0.2181
Echinococcus multilocularis GPCR, family 2 0.0047 0.0299 0.0299
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.1249 0.219
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0036 0.0056
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0036 0.0036
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.078 0.1873
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0158 0.0158
Leishmania major hypothetical protein, conserved 0.0114 0.0925 0.2677
Mycobacterium tuberculosis Conserved protein 0.0114 0.0925 0.134
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0217 0.2041
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0303 0.0565
Loa Loa (eye worm) hypothetical protein 0.0047 0.0299 0.0524
Toxoplasma gondii exonuclease III APE 0.0038 0.0217 0.0538
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0809 0.1943
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0158 0.0158
Onchocerca volvulus 0.0114 0.0925 0.1943
Loa Loa (eye worm) hypothetical protein 0.0078 0.0591 0.1037
Brugia malayi ecdysteroid receptor 0.0032 0.0158 0.0379
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0378 0.3406 0.5974
Schistosoma mansoni hypothetical protein 0.0041 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0041 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0101 0.0809 0.1419
Echinococcus granulosus zinc finger protein 0.0022 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.003
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.0925 0.134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0158 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0925 0.2677
Loa Loa (eye worm) hypothetical protein 0.0042 0.0254 0.0446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.2109 0.2109
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0036 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.012 0.2285
Brugia malayi beta-lactamase family protein 0.0114 0.0925 0.222
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.078 1
Schistosoma mansoni zinc finger protein 0.0022 0.0062 0.0062
Entamoeba histolytica Ran family GTPase 0.0043 0.0262 0.3032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.0925 0.0925
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0041 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.2109 0.2109
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0035 0.0053
Echinococcus granulosus intermediate filament protein 0.0028 0.0121 0.0121
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0158 0.0277
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0036 0.0056
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0092 0.0092
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0036 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0158 0.0158
Onchocerca volvulus Alhambra homolog 0.0058 0.0405 0.0851
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0277
Brugia malayi CHE-14 protein 0.0042 0.0254 0.061
Brugia malayi Importin beta-1 subunit 0.0058 0.0406 0.0976
Onchocerca volvulus 0.0038 0.0213 0.0448
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0213 0.0374
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0406 0.1101
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0378 0.3406 1
Entamoeba histolytica hypothetical protein 0.0047 0.0303 0.3583
Loa Loa (eye worm) hypothetical protein 0.0114 0.0925 0.1622
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0121 0.0212
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.054 0.054
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0056
Schistosoma mansoni kinase 0.0049 0.0315 0.0315
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.012 0.2285
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.0925 0.134
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0262 0.2547
Schistosoma mansoni hypothetical protein 0.0047 0.0299 0.0299
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0378 0.3406 0.3406
Brugia malayi Bromodomain containing protein 0.0061 0.043 0.1032
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0036 0.0036
Echinococcus granulosus high affinity choline transporter 1 0.0342 0.3071 0.3071
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0406 0.1147
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0158 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0158 0.0379
Echinococcus granulosus lamin dm0 0.0028 0.0121 0.0121
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0405 0.4159
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0213 0.0213
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0277
Echinococcus multilocularis protein dispatched 1 0.0048 0.031 0.031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0231 0.0231
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.024 0.2109 0.5064
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0158 0.0158
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.003
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0254 0.0254
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0017 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0017 0.0017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0299 0.0299
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0035 0.0035
Trypanosoma brucei polo-like protein kinase 0.0096 0.0756 0.2181
Loa Loa (eye worm) hypothetical protein 0.0047 0.0301 0.0527
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0217 0.0382
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0277
Brugia malayi jmjC domain containing protein 0.0019 0.0035 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0756 0.1524
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0158 0.0158
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0036 0.0036
Schistosoma mansoni sodium/solute symporter 0.0038 0.0213 0.0213
Giardia lamblia Kinase, PLK 0.0096 0.0756 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0158 0.0379
Loa Loa (eye worm) beta-lactamase 0.0114 0.0925 0.1622
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0213 0.0528
Schistosoma mansoni ran 0.0043 0.0262 0.0262
Brugia malayi beta-lactamase family protein 0.0114 0.0925 0.222
Echinococcus granulosus GPCR family 2 0.0047 0.0299 0.0299
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0217 0.2031
Brugia malayi PHD-finger family protein 0.0027 0.0117 0.0281
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0035 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0035 0.0062
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0217 0.5
Echinococcus granulosus dna polymerase eta 0.0019 0.0036 0.0036
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.0925 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0262 0.0672
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0037 0.0007
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0217 0.5
Schistosoma mansoni hypothetical protein 0.0047 0.0299 0.0299
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0378 0.3406 1
Leishmania major 0.0378 0.3406 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0925 0.1622
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0037 0.006
Mycobacterium ulcerans lipase LipD 0.0114 0.0925 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0037 0.0059
Plasmodium falciparum phd finger protein, putative 0.0058 0.0405 0.997
Echinococcus granulosus lamin 0.0028 0.0121 0.0121
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0303 0.0842
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0213 0.0512
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.024 0.2109 0.3699
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0254 0.0446
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.1249 0.2998
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0035 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0303 0.0565
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0158 0.0158
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0756 0.0756
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.078 0.078
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0158 0.0379
Mycobacterium ulcerans beta-lactamase 0.0114 0.0925 1
Schistosoma mansoni ap endonuclease 0.0038 0.0217 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0756 0.1524
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0756 0.2181
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0262 0.0721
Echinococcus granulosus muscleblind protein 0.0309 0.2762 0.2762
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0158 0.0158
Trichomonas vaginalis esterase, putative 0.0114 0.0925 0.1881
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0158 0.0158
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0756 0.9685
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0158 0.0332
Loa Loa (eye worm) hypothetical protein 0.0098 0.078 0.1368
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.01
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.0987 0.1731
Brugia malayi nuclear receptor NHR-88 0.0032 0.0158 0.0379
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0925 0.1881
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.012 0.0303
Loa Loa (eye worm) hypothetical protein 0.0342 0.3071 0.5386
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0035 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0756 0.1524
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0204
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0035 0.0035
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0262 0.0721
Brugia malayi nuclear receptor RXR 0.0017 0.0017 0.0041
Echinococcus multilocularis muscleblind protein 1 0.0309 0.2762 0.2762
Loa Loa (eye worm) hypothetical protein 0.0052 0.0343 0.0602
Schistosoma mansoni hypothetical protein 0.0047 0.0299 0.0299
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0254 0.0254
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0925 0.2677
Brugia malayi hypothetical protein 0.0017 0.0017 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0158 0.0379
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0623 0.5702 0.5702
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.012 0.0953
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0378 0.3406 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0158 0.0158
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0035 0.0053
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0726 0.6668 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0756 0.0756
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.099 0.1736
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0262 0.313
Mycobacterium leprae Probable lipase LipE 0.0114 0.0925 0.5
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.0925 0.134
Toxoplasma gondii fructose-bisphospatase I 0.0141 0.1178 0.339
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0191 0.1648 0.1648
Echinococcus granulosus dna polymerase kappa 0.0019 0.0036 0.0036
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1175 0.1175
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0303 0.0564
Loa Loa (eye worm) hypothetical protein 0.0032 0.0158 0.0277
Giardia lamblia PHD finger protein 15 0.0058 0.0405 0.5122
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0217 0.2426
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0035 0.0062
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0619 0.0619
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0299 0.0717
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0158 0.0158
Brugia malayi jmjC domain containing protein 0.0073 0.054 0.1296
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0158 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0085 0.0653 0.0653
Brugia malayi AF-10 protein 0.0019 0.0037 0.009
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0056
Loa Loa (eye worm) hypothetical protein 0.0114 0.0925 0.1622
Brugia malayi MH2 domain containing protein 0.0121 0.099 0.2377
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0141 0.1178 0.3425
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0217 0.0272
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0073 0.0127
Brugia malayi jmjC domain containing protein 0.0019 0.0035 0.0085
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0158 0.0379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0158 0.0277
Onchocerca volvulus 0.0028 0.0121 0.0255

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 8 % Antidiabetic activity in C57BLKS db/db mouse assessed as reduction in glucose level at 100 mg/kg, po after 2 hrs relative to control ChEMBL. 19969452
Activity (functional) = 11 % Antidiabetic activity in C57BLKS db/db mouse assessed as reduction in glucose level at 100 mg/kg, po after 4 hrs relative to control ChEMBL. 19969452
Activity (functional) = 26 % Antidiabetic activity in C57BLKS db/db mouse assessed as reduction in glucose level at 100 mg/kg, po after 6 hrs relative to control ChEMBL. 19969452
EC50 (binding) = 14 uM Inhibition of FBPase in mouse liver ChEMBL. 19969452
IC50 (binding) = 0.17 uM Inhibition of FBPase in human liver ChEMBL. 19969452

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.