Detailed information for compound 1112678

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.423 | Formula: C25H16F3N5O
  • H donors: 1 H acceptors: 4 LogP: 4.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)C(F)(F)F)Nc1cccc(c1)c1ccnc2n1ncc2c1cccnc1
  • InChi: 1S/C25H16F3N5O/c26-25(27,28)19-7-1-5-17(12-19)24(34)32-20-8-2-4-16(13-20)22-9-11-30-23-21(15-31-33(22)23)18-6-3-10-29-14-18/h1-15H,(H,32,34)
  • InChiKey: UAQFLCCYSVWUFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens B-Raf proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus granulosus raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma japonicum ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) TKL/RAF/RAF protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Brugia malayi Raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0266 0.3104
Loa Loa (eye worm) hypothetical protein 0.0132 0.222 0.2546
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0778 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0106 0.0122
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0266 0.0028
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0488 0.0559
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.3457 0.6899
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0266 0.0028
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0516 0.0844
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0778 0.9101
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0777 0.1215
Brugia malayi nuclear receptor NHR-88 0.0031 0.0106 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.1527 0.2571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.045 0.0623
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0332 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.2831 0.5611
Echinococcus granulosus tar DNA binding protein 0.0064 0.0799 0.1426
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0465 0.0649
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0487 0.0783
Schistosoma mansoni bromodomain containing protein 0.0136 0.2309 0.3987
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.045 0.0708
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0606 0.0904
Brugia malayi MH2 domain containing protein 0.0245 0.4611 0.5288
Schistosoma mansoni hypothetical protein 0.0049 0.0487 0.0688
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0606 0.1029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0106 0.0122
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0465 0.0649
Schistosoma mansoni hypothetical protein 0.0049 0.0487 0.0688
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0516 0.6638
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0266 0.0028
Echinococcus multilocularis transcription factor btf3 0.0038 0.0239 0.0273
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0266 0.0436
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0266 0.0028
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0197 0.0187
Brugia malayi mbt repeat family protein 0.0048 0.0465 0.0533
Loa Loa (eye worm) hypothetical protein 0.0089 0.1318 0.1512
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0799 0.1253
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0106 0.0122
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0266 0.0328
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0606 0.1029
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0465 0.0739
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0262 0.0322
Schistosoma mansoni hypothetical protein 0.0032 0.012 0.0025
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.1027 0.1896
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0266 0.3411
Schistosoma mansoni transcription factor btf3 0.0038 0.0239 0.024
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0799 0.1426
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0778 0.1385
Loa Loa (eye worm) hypothetical protein 0.0031 0.0106 0.0122
Plasmodium vivax SET domain protein, putative 0.0063 0.0777 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.4611 0.5288
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0778 0.1217
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.3457 0.6899
Loa Loa (eye worm) acetyltransferase 0.0161 0.2831 0.3247
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0487 0.0783
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0778 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.2732 0.3133
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0516 0.0284
Trypanosoma cruzi ISWI complex protein 0.0032 0.012 0.1402
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0239 0.2789
Loa Loa (eye worm) hypothetical protein 0.0055 0.0606 0.0695
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0197 0.0165
Schistosoma mansoni alpha glucosidase 0.0039 0.0266 0.0288
Loa Loa (eye worm) hypothetical protein 0.0156 0.2732 0.3133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.1527 0.2571
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0516 0.0284
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0465 0.0363
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.3134 0.3595
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0262 0.0322
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0799 0.0916
Loa Loa (eye worm) hypothetical protein 0.0093 0.1402 0.1608
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.045 0.0623
Brugia malayi ecdysteroid receptor 0.0031 0.0106 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0799 0.1253
Loa Loa (eye worm) hypothetical protein 0.0048 0.0465 0.0533
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0606 0.1029
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0266 0.0436
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0855 0.1543
Onchocerca volvulus 0.0048 0.0465 0.0363
Schistosoma mansoni hypothetical protein 0.0049 0.0487 0.0688
Echinococcus granulosus zinc finger protein 0.0045 0.0388 0.0581
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0266 0.0328
Loa Loa (eye worm) hypothetical protein 0.0147 0.2556 0.2932
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0777 0.1382
Brugia malayi TAR-binding protein 0.0064 0.0799 0.0916
Loa Loa (eye worm) MBCTL1 0.0055 0.0606 0.0695
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0332 0.1507
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0778 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.045 0.0623
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0465 0.0739
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0799 0.0916
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0239 0.307
Brugia malayi hypothetical protein 0.0132 0.222 0.2546
Loa Loa (eye worm) RNA binding protein 0.0064 0.0799 0.0916
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0099 0.1527 0.2926
Leishmania major basic transcription factor 3a, putative 0.0038 0.0239 0.2789
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.1692 0.1941
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0197 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0106 0.0122
Loa Loa (eye worm) hypothetical protein 0.0031 0.0106 0.0122
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.045 0.0516
Schistosoma mansoni alpha-glucosidase 0.0151 0.2621 0.4551
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0106 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0799 0.1253
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0106 0.0122
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0465 0.0739
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0606 0.1029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0106 0.0122
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0266 0.0028
Loa Loa (eye worm) hypothetical protein 0.0099 0.1527 0.1751
Brugia malayi mbt repeat family protein 0.0048 0.0465 0.0533
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0106 0.0122
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.3134 0.3595
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0778 0.1217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0106 0.0122
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0239 0.0274
Trypanosoma brucei ISWI complex protein 0.0032 0.012 0.1402
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0778 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0262 0.4963 0.8789
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0855 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0855 1
Trypanosoma cruzi ISWI complex protein 0.0032 0.012 0.1402
Brugia malayi Bromodomain containing protein 0.0084 0.1211 0.1389
Echinococcus multilocularis GPCR, family 2 0.0049 0.0487 0.0783
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0855 0.1543
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0438 0.0684
Loa Loa (eye worm) hypothetical protein 0.0031 0.0106 0.0122
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0266 0.0028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.045 0.0516
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.045 0.0708
Loa Loa (eye worm) hypothetical protein 0.0049 0.0487 0.0558
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0106 0.0122
Echinococcus granulosus raf serine:threonine protein kinase 0.0262 0.4963 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0106 0.0122
Loa Loa (eye worm) hypothetical protein 0.0132 0.222 0.2546
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0855 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0106 0.0122
Echinococcus multilocularis geminin 0.0171 0.3062 0.6086
Onchocerca volvulus Huntingtin homolog 0.0132 0.222 0.2136
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0465 0.0739
Echinococcus granulosus geminin 0.0171 0.3062 0.6086
Loa Loa (eye worm) hypothetical protein 0.008 0.1134 0.1301
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0438 0.0601
Trichomonas vaginalis set domain proteins, putative 0.0501 1 1
Schistosoma mansoni hypothetical protein 0.0171 0.3062 0.5348
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0855 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.1692 0.1941
Schistosoma mansoni hypothetical protein 0.0106 0.1692 0.2871
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0266 0.0305
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.3134 0.6235
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0106 0.0122
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0465 0.0649
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0106 0.0122
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0855 0.0981
Brugia malayi Pre-SET motif family protein 0.0063 0.0777 0.0892
Brugia malayi RNA binding protein 0.0064 0.0799 0.0916
Echinococcus granulosus transcription factor btf3 0.0038 0.0239 0.0273
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0266 0.0028
Onchocerca volvulus Huntingtin homolog 0.0132 0.222 0.2136
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0266 0.3104
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0516 0.6628
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.2732 0.3133
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0799 0.1253
Loa Loa (eye worm) hypothetical protein 0.0031 0.0106 0.0122
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0516 0.6628
Loa Loa (eye worm) hypothetical protein 0.0031 0.0106 0.0122
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.2635 0.5208
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0606 0.0695
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0487 0.0783
Loa Loa (eye worm) hypothetical protein 0.0031 0.0106 0.0122
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0239 0.7196
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0487 0.0558
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0799 0.1253
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0855 0.0981
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0106 0.0122
Loa Loa (eye worm) hypothetical protein 0.0031 0.0106 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0106 0.0122
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0487 0.0558
Echinococcus multilocularis zinc finger protein 0.0045 0.0388 0.0581
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0106 0.0122
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0332 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.3134 0.6235
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.045 0.0708
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0487 0.0783
Brugia malayi steroid hormone receptor 0.0031 0.0106 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0106 0.0122
Brugia malayi PHD-finger family protein 0.0056 0.0623 0.0714
Brugia malayi Raf kinase 0.0253 0.477 0.5471
Leishmania major hypothetical protein, conserved 0.0032 0.012 0.1402
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.045 0.0708
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0487 0.0558
Loa Loa (eye worm) raf kinase 0.026 0.4936 0.5661
Brugia malayi Pre-SET motif family protein 0.044 0.8719 1
Trypanosoma brucei glucosidase, putative 0.0039 0.0266 0.3104
Schistosoma mansoni zinc finger protein 0.0032 0.012 0.0025
Schistosoma mansoni hypothetical protein 0.0293 0.5632 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0855 0.1356
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.044 0.8719 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.2831 0.4931
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0778 0.1385
Schistosoma mansoni alpha-glucosidase 0.0151 0.2621 0.4551
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0128 0.2152 0.4213
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.1027 0.1896
Schistosoma mansoni zinc finger protein 0.0045 0.0388 0.0511
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.2732 0.3133
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0266 0.3104
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0778 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0266 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0106 0.0122
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0728 0.1281
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0855 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0148 0.2574 0.2953
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0128 0.2152 0.4213
Echinococcus multilocularis raf serine:threonine protein kinase 0.0262 0.4963 1
Onchocerca volvulus 0.0063 0.0777 0.0678
Loa Loa (eye worm) bromodomain containing protein 0.0041 0.0304 0.0349
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.3134 0.6235
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0106 0.0122
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0465 0.0533
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0197 0.0187
Brugia malayi Bromodomain containing protein 0.016 0.2825 0.3239
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0106 0.0122
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.4611 0.5288
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0799 0.0916
Onchocerca volvulus 0.0101 0.158 0.1489
Schistosoma mansoni hypothetical protein 0.0049 0.0487 0.0688
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0777 0.1215
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0438 0.0684
Schistosoma mansoni hypothetical protein 0.0171 0.3062 0.5348
Brugia malayi Cytochrome P450 family protein 0.0049 0.0488 0.0559
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0266 0.0305
Echinococcus granulosus GPCR family 2 0.0049 0.0487 0.0783
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0106 0.0122
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0266 0.0028
Brugia malayi nuclear hormone receptor 0.0031 0.0106 0.0122
Brugia malayi beta-NAC-like protein 0.0038 0.0239 0.0274
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0106 0.0122
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0777 0.9985
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0239 0.2789
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0239 0.2789
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0106 0.0122
Loa Loa (eye worm) hypothetical protein 0.0031 0.0106 0.0122
Echinococcus granulosus histone lysine methyltransferase setb 0.0099 0.1527 0.2926
Schistosoma mansoni hypothetical protein 0.0043 0.0354 0.0449
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0354 0.0406
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.2831 0.3247
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0239 0.3065

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.113 uM Inhibition of human recombinant B-Raf expressed in Sf9 cells ChEMBL. 19864136
IC50 (functional) = 3.7 uM Cytotoxicity against human HT-29 cells expressing B-Raf mutant ChEMBL. 19864136

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19864136

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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