Detailed information for compound 1125997

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 479.573 | Formula: C29H29N5O2
  • H donors: 2 H acceptors: 3 LogP: 5.11 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2n(c1)c(c(n2)C)N(C(=O)CCc1ccccc1)C)NCCc1c[nH]c2c1cccc2
  • InChi: 1S/C29H29N5O2/c1-20-29(33(2)27(35)15-12-21-8-4-3-5-9-21)34-19-23(13-14-26(34)32-20)28(36)30-17-16-22-18-31-25-11-7-6-10-24(22)25/h3-11,13-14,18-19,31H,12,15-17H2,1-2H3,(H,30,36)
  • InChiKey: ZFJUULRFDBWZQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0051 0.0173 0.0734
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0247 0.1418
Echinococcus granulosus solute carrier family 22 0.0014 0.0019 0.0033
Echinococcus multilocularis aldo keto reductase 0.0051 0.0173 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0018 0.0121
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.019 0.1649
Entamoeba histolytica hypothetical protein 0.0107 0.0405 0.2858
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Schistosoma mansoni hypothetical protein 0.0179 0.0704 0.1253
Mycobacterium ulcerans hydrolase 0.0106 0.0402 0.3522
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Trichomonas vaginalis penicillin-binding protein, putative 0.0069 0.0247 0.2169
Schistosoma mansoni hypothetical protein 0.003 0.0085 0.0151
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0005 0.0005
Schistosoma mansoni transient receptor potential channel 0.0097 0.0365 0.065
Trypanosoma cruzi aldo-keto reductase 0.0051 0.0173 0.6979
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0005 0.0044
Toxoplasma gondii ABC1 family protein 0.0069 0.0247 0.2156
Trichomonas vaginalis sugar transporter, putative 0.0031 0.009 0.0778
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0005 0.0005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0044 0.0141 0.571
Brugia malayi Matrixin family protein 0.0087 0.0323 0.2724
Schistosoma mansoni hypothetical protein 0.0041 0.013 0.0231
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0364 0.0648
Onchocerca volvulus Matrix metalloproteinase homolog 0.0193 0.0765 1
Onchocerca volvulus 0.0048 0.0158 0.2007
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0019 0.0163
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0053 0.216
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0352 0.0626
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0088 0.0507
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0051 0.0173 0.0173
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0247 0.2169
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0018 0.0112
Echinococcus multilocularis aldo keto reductase 0.0051 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0179 0.0704 0.1253
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0051 0.0173 0.0173
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.019 0.0339
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0051 0.0051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0005 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.038 0.3341
Brugia malayi beta-lactamase family protein 0.0069 0.0247 0.2088
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0005 0.0009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0089 0.0089
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0441 0.1798 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.1185 0.5039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0022
Schistosoma mansoni glucose transport protein 0.0101 0.038 0.0676
Mycobacterium ulcerans hypothetical protein 0.0015 0.0021 0.0152
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.038 0.0676
Schistosoma mansoni patched 1 0.0042 0.0136 0.0242
Plasmodium falciparum importin beta, putative 0.0054 0.0184 0.1053
Brugia malayi major facilitator superfamily protein 0.0014 0.0019 0.0158
Schistosoma mansoni hypothetical protein 0.0041 0.013 0.0231
Echinococcus multilocularis beta LACTamase domain containing family member 0.0069 0.0247 0.0247
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0051 0.0173 0.0307
Echinococcus multilocularis transportin 1 0.001 0.0002 0.0002
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Schistosoma mansoni hypothetical protein 0.0051 0.0171 0.0305
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0364 0.0364
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0005 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Trypanosoma brucei glucose transporter, putative 0.0031 0.009 0.3638
Brugia malayi glutaminase DH11.1 0.0282 0.1134 0.9567
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.023
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0008 0.0045
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0044 0.0141 0.1231
Brugia malayi hypothetical protein 0.0146 0.0567 0.4789
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0005 0.0009
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0042 0.0353
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.008 0.0339
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0053 0.216
Echinococcus multilocularis microtubule associated protein 2 0.1359 0.562 0.562
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0018 0.0719
Echinococcus granulosus aldehyde reductase 0.0036 0.0111 0.0197
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0247 1
Brugia malayi Transient-receptor-potential like protein 0.0036 0.011 0.0932
Echinococcus multilocularis solute carrier family 22 0.0014 0.0019 0.0019
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0019 0.0033
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.038 0.0676
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0088 0.0507
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0051 0.0173 0.1457
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Trypanosoma cruzi aldo/keto reductase, putative 0.0015 0.0021 0.0861
Trichomonas vaginalis glutaminase, putative 0.0282 0.1134 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0015 0.0021 0.0137
Leishmania major glucose transporter, lmgt3 0.0031 0.009 0.3638
Echinococcus multilocularis importin subunit beta 1 0.0054 0.0184 0.0184
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.0148
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0574 0.2351 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0018 0.0102
Echinococcus granulosus cpg binding protein 0.003 0.0086 0.0154
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0051 0.0173 0.0307
Echinococcus granulosus transportin 1 0.001 0.0002 0.0003
Echinococcus granulosus hypothetical protein 0.0051 0.0173 0.0307
Echinococcus multilocularis solute carrier family 22 0.0014 0.0019 0.0019
Schistosoma mansoni transient receptor potential channel 0.0064 0.0228 0.0406
Echinococcus granulosus translational activator gcn1 0.001 0.0002 0.0003
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0089 0.3606
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0019 0.0129
Loa Loa (eye worm) hypothetical protein 0.0087 0.0323 0.1373
Entamoeba histolytica protein kinase, putative 0.0031 0.0088 0.0612
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0005 0.0009
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0019 0.0148
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0053 0.0455
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.019 0.101
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0118 0.021
Onchocerca volvulus 0.0014 0.0019 0.0177
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Loa Loa (eye worm) oxidoreductase 0.0051 0.0173 0.0734
Loa Loa (eye worm) hypothetical protein 0.0048 0.0158 0.0671
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0044 0.0144 0.0612
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0018 0.0045
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0108 0.0643
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0023 0.0053 0.0365
Schistosoma mansoni hypothetical protein 0.0041 0.013 0.0231
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0005 0.0009
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0018 0.014
Onchocerca volvulus 0.0051 0.0173 0.2202
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0022
Schistosoma mansoni importin beta-1 0.0054 0.0184 0.0327
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0086 0.0153
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0086 0.0153
Loa Loa (eye worm) hypothetical protein 0.0061 0.0214 0.0912
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0051 0.2051
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0005 0.0009
Echinococcus granulosus importin 5 0.001 0.0002 0.0003
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0085 0.0085
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0005 0.0005
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0085 0.0151
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0085 0.0739
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0005 0.0022
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0018 0.0121
Schistosoma mansoni cpg binding protein 0.0029 0.008 0.0142
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0018 0.015
Brugia malayi hypothetical protein 0.0014 0.0019 0.0158
Trypanosoma brucei glucose transporter, putative 0.0031 0.009 0.3638
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0108 0.0917
Entamoeba histolytica hypothetical protein 0.0107 0.0405 0.2858
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0046 0.1846
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0005 0.0022
Trypanosoma brucei sugar transporter, putative 0.0014 0.0019 0.0756
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.0086 0.0365
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0046 0.0194
Onchocerca volvulus 0.0014 0.0019 0.0177
Echinococcus multilocularis protein patched 0.0042 0.0136 0.0136
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0007 0.0012
Echinococcus granulosus voltage gated potassium channel subunit 0.0015 0.0021 0.0038
Brugia malayi jmjC domain containing protein 0.0038 0.0118 0.0996
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0158 0.136
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0264
Plasmodium falciparum mitogen-activated protein kinase 2 0.0163 0.0639 0.3664
Brugia malayi nuclear receptor NHR-88 0.0011 0.0005 0.0044
Brugia malayi hypothetical protein 0.0249 0.0998 0.8427
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0108 0.4381
Trypanosoma brucei glucose transporter, putative 0.0031 0.009 0.3638
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0037 0.0314
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.019 0.019
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0088 0.0157
Echinococcus granulosus expressed conserved protein 0.0093 0.0346 0.0616
Brugia malayi steroid hormone receptor 0.0011 0.0005 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0364 0.0648
Brugia malayi Sugar transporter family protein 0.0101 0.038 0.3207
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Schistosoma mansoni glucose transport protein 0.0101 0.038 0.0676
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0317 0.128 0.2278
Loa Loa (eye worm) hypothetical protein 0.0052 0.0176 0.0748
Leishmania major importin beta-1 subunit, putative 0.0044 0.0141 0.571
Echinococcus granulosus importin subunit beta 1 0.0054 0.0184 0.0327
Mycobacterium tuberculosis Conserved protein 0.0069 0.0247 0.1329
Entamoeba histolytica aldose reductase, putative 0.0051 0.0173 0.121
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0086 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0018 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0108 0.094
Plasmodium vivax sugar transporter, putative 0.0014 0.0019 0.0107
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0019 0.0158
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0108 0.4381
Echinococcus granulosus solute carrier family 22 0.0014 0.0019 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Echinococcus granulosus microtubule associated protein 2 0.1359 0.562 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0136 0.1186
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0015 0.0021 0.0171
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0548 0.0548
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0088 0.0507
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0108 0.4381
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0039 0.0165
Loa Loa (eye worm) hypothetical protein 0.0106 0.0402 0.171
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0005 0.0005
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0051 0.0173 0.0307
Schistosoma mansoni pol-related 0.0051 0.0173 0.0307
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0044 0.0144 0.0144
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0158 0.1332
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.0158 0.0671
Leishmania major aldo-keto reductase-like protein 0.0051 0.0173 0.6979
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0046 0.0081
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0018 0.0121
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.037 0.037
Brugia malayi CXXC zinc finger family protein 0.0029 0.008 0.0672
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0005 0.0044
Schistosoma mansoni hypothetical protein 0.0096 0.0358 0.0636
Brugia malayi RNA, U transporter 1 0.0153 0.0597 0.5036
Trypanosoma brucei prostaglandin f synthase 0.0051 0.0173 0.6979
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0018 0.0045
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0317 0.128 0.128
Trypanosoma brucei glucose transporter, putative 0.0031 0.009 0.3638
Trypanosoma cruzi hexose transporter, putative 0.0031 0.009 0.3638
Leishmania major hypothetical protein, conserved 0.0014 0.0019 0.0756
Leishmania major glucose transporter, lmgt2 0.0031 0.009 0.3638
Trypanosoma brucei aldo-keto reductase, putative 0.0051 0.0173 0.6979
Schistosoma mansoni hypothetical protein 0.001 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0364 0.0648
Echinococcus granulosus muscleblind protein 0.0294 0.1185 0.2108
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0022
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.001 0.0404
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0108 0.0193
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0089 0.0159
Loa Loa (eye worm) hypothetical protein 0.0069 0.0247 0.1052
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0046 0.0262
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0015 0.0021 0.0861
Schistosoma mansoni cpg binding protein 0.003 0.0086 0.0154
Mycobacterium ulcerans glutaminase 0.0282 0.1134 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0005 0.0044
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0018 0.0076
Mycobacterium leprae PROBABLE HYDROLASE 0.0106 0.0402 1
Onchocerca volvulus 0.0014 0.0019 0.0177
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0051 0.0173 0.1457
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.003 0.0054
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0005 0.0044
Onchocerca volvulus Alhambra homolog 0.003 0.0085 0.1047
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.009 0.3638
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0213 0.1139
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0089 0.0777
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0018 0.0121
Loa Loa (eye worm) hypothetical protein 0.0294 0.1185 0.5039
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0018 0.0102
Onchocerca volvulus 0.0014 0.0019 0.0177
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Schistosoma mansoni hypothetical protein 0.0101 0.038 0.0676
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0088 0.0088
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.011 0.011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0187 0.163
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0136 0.0136
Mycobacterium leprae conserved hypothetical protein 0.0069 0.0247 0.5975
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0088 0.0376
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0213 0.038
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0158 0.1332
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Brugia malayi Importin beta-1 subunit 0.0054 0.0184 0.155
Onchocerca volvulus 0.0014 0.0019 0.0177
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0046 0.0193
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0069 0.0247 0.1329
Echinococcus granulosus solute carrier family 22 0.0014 0.0019 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0015 0.0021 0.0091
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0053 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.01 0.0503
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0018 0.0045
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0089 0.0089
Toxoplasma gondii HEAT repeat-containing protein 0.001 0.0002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0249 0.0998 0.4247
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0053 0.4761
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0136 0.0242
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0018 0.0719
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0548 0.0975
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Loa Loa (eye worm) oxidoreductase 0.0014 0.0018 0.0076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0364 0.0364
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0158 0.136
Echinococcus multilocularis GPCR, family 2 0.0044 0.0144 0.0144
Onchocerca volvulus 0.0124 0.0475 0.6176
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0015 0.0021 0.0038
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0107 0.4311
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0046 0.0385
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Onchocerca volvulus 0.0014 0.0019 0.0177
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.009 0.3638
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0018 0.0121
Loa Loa (eye worm) matrixin family protein 0.0211 0.0838 0.3563
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.01 0.0503
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0018 0.015
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0111 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0005 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0005 0.0022
Schistosoma mansoni hypothetical protein 0.0574 0.2351 0.4184
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0053 0.0095
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0089 0.0444
Loa Loa (eye worm) hypothetical protein 0.0054 0.0184 0.0781
Schistosoma mansoni coup transcription factor 0.0011 0.0005 0.0009
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.1037 0.4277 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0088 0.0507
Onchocerca volvulus 0.0014 0.0019 0.0177
Brugia malayi Matrixin family protein 0.0087 0.0323 0.2724
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0051 0.0173 0.0307
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0086 0.0153
Loa Loa (eye worm) hypothetical protein 0.0033 0.0097 0.0412
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Leishmania major hypothetical protein, conserved 0.001 0.0002 0.0079
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0005 0.0009
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0053 0.0451
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0044 0.0144 0.0256
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0046 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0005 0.0009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0158 0.1105
Toxoplasma gondii protein kinase, putative 0.0285 0.1147 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0365 0.1554
Entamoeba histolytica aldose reductase, putative 0.0051 0.0173 0.121
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.009 0.0778
Entamoeba histolytica hypothetical protein 0.0107 0.0405 0.2858
Loa Loa (eye worm) hypothetical protein 0.0069 0.0247 0.1052
Loa Loa (eye worm) glutaminase 2 0.0282 0.1134 0.4821
Brugia malayi hypothetical protein 0.0014 0.0019 0.0158
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.0216
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.044 0.1871
Schistosoma mansoni protein kinase 0.0031 0.0088 0.0157
Loa Loa (eye worm) hypothetical protein 0.0044 0.0144 0.0612
Schistosoma mansoni hypothetical protein 0.0041 0.013 0.0231
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0371 0.0371
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0051 0.0173 0.0173
Giardia lamblia DNA repair protein RAD52 0.0349 0.1413 1
Brugia malayi nuclear hormone receptor 0.0011 0.0005 0.0044
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0072 0.026 0.0462
Schistosoma mansoni potassium channel beta 0.0015 0.0021 0.0038
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0018 0.014
Schistosoma mansoni protein kinase 0.0031 0.0088 0.0157
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0005 0.0009
Echinococcus multilocularis cpg binding protein 0.003 0.0086 0.0086
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0018 0.0719
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0031
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0086 0.074
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0019 0.0756
Toxoplasma gondii sugar transporter ST2 0.0014 0.0019 0.0163
Onchocerca volvulus 0.0014 0.0019 0.0177
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0088 0.0088
Trypanosoma brucei glucose transporter 1E 0.0031 0.009 0.3638
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0171 0.1447
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0005 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.01 0.0503
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.038 0.038
Echinococcus granulosus snurportin 1 0.0574 0.2351 0.4184
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0088 0.0745
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0134 0.0134
Trichomonas vaginalis ran, putative 0.0022 0.0051 0.0431
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Trichomonas vaginalis aldo-keto reductase, putative 0.0015 0.0021 0.0171
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0175 0.0744
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0019 0.0756
Loa Loa (eye worm) hypothetical protein 0.0036 0.0108 0.0458
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0088 0.077
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0118 0.021
Trypanosoma brucei hypothetical protein, conserved 0.0069 0.0247 1
Schistosoma mansoni cpg binding protein 0.003 0.0086 0.0154
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0005 0.0009
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0108 0.0754
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0019 0.0129
Trichomonas vaginalis importin beta-1, putative 0.0044 0.0141 0.1231
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Trypanosoma brucei glucose transporter, putative 0.0031 0.009 0.3638
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0051 0.0173 0.6979
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0019 0.0033
Loa Loa (eye worm) beta-lactamase 0.0069 0.0247 0.1052
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0069 0.0247 0.1329
Schistosoma mansoni hypothetical protein 0.0124 0.0475 0.0844
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0018 0.0121
Schistosoma mansoni hypothetical protein 0.0107 0.0405 0.0721
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0053 0.0306
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0088 0.0088
Brugia malayi Bromodomain containing protein 0.003 0.0085 0.0716
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0247 0.2169
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0005 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.01 0.0503
Leishmania major hypothetical protein, conserved 0.0069 0.0247 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0018 0.0155
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.038 0.0676
Brugia malayi beta-lactamase family protein 0.0069 0.0247 0.2088
Giardia lamblia Aldose reductase 0.0051 0.0173 0.1104
Loa Loa (eye worm) hypothetical protein 0.0096 0.0358 0.1521
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0005 0.0009
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0018 0.0032
Mycobacterium tuberculosis Probable oxidoreductase 0.0051 0.0173 0.0911
Echinococcus granulosus GPCR family 2 0.0044 0.0144 0.0256
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0228 0.0228
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0158 0.3644
Brugia malayi latrophilin 2 splice variant baaae 0.0096 0.0358 0.3017
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0019 0.005
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0018 0.0719
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.038 0.038
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0163 0.0639 0.5569
Loa Loa (eye worm) sugar transporter 0.0101 0.038 0.1616
Plasmodium falciparum protein kinase 7 0.0285 0.1147 0.6579
Loa Loa (eye worm) sugar transporter 0.0014 0.0019 0.008
Echinococcus granulosus aldo keto reductase 0.0051 0.0173 0.0307
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0005 0.0044
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0106 0.0402 0.3392
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0106 0.0402 0.2193
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Schistosoma mansoni sugar transporter 0.0014 0.0019 0.0033
Brugia malayi Latrophilin receptor protein 2 0.0044 0.0144 0.1213
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0349 0.1413 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0158 0.1332
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0364 0.1549
Leishmania major GTP-binding protein, putative 0.0022 0.0051 0.2051
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Onchocerca volvulus 0.0018 0.0033 0.0369
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0018 0.0045
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0069 0.0247 0.1052
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.038 0.038
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0087 0.0323 0.1373
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.0148
Onchocerca volvulus 0.0051 0.0171 0.2188
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0015 0.0021 0.018
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0018 0.0018
Onchocerca volvulus Putative transporter 0.0014 0.0019 0.0177
Mycobacterium ulcerans hypothetical protein 0.0048 0.0158 0.136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0364 0.0648
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0018 0.0121
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0085 0.0151
Echinococcus multilocularis translational activator gcn1 0.001 0.0002 0.0002
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0051 0.0173 0.1508
Schistosoma mansoni aldo-keto reductase 0.0051 0.0173 0.0307
Trypanosoma brucei aldo/keto reductase, putative 0.0015 0.0021 0.0861
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0022
Onchocerca volvulus 0.0051 0.0173 0.2202
Loa Loa (eye worm) hypothetical protein 0.0069 0.0247 0.1052
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.008 0.0143
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0019 0.0019
Mycobacterium tuberculosis Conserved protein 0.0069 0.0247 0.1329
Mycobacterium leprae Probable lipase LipE 0.0069 0.0247 0.5975
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0377 0.0672
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0018 0.0045
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0046 0.031
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0158 0.136
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0018 0.0121
Onchocerca volvulus 0.0051 0.0173 0.2202
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.019 0.1649
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0069 0.0247 0.044
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0089 0.3606
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0247 1
Schistosoma mansoni hypothetical protein 0.0044 0.0144 0.0256
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0019 0.0148
Leishmania major glucose transporter, lmgt1 0.0031 0.009 0.3638
Echinococcus multilocularis muscleblind protein 1 0.0294 0.1185 0.1185
Entamoeba histolytica hypothetical protein 0.0107 0.0405 0.2858
Mycobacterium tuberculosis Probable lipase LipE 0.0069 0.0247 0.1329
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0088 0.0507
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0051 0.0173 0.0173
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0018 0.0719
Plasmodium falciparum transportin 0.001 0.0002 0.0011
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0088 0.0157
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0089 0.0511
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0051 0.0173 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0005 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0005 0.0022
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0089 0.0089
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0005 0.0009
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0018 0.0719
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0108 0.0548
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.0291
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.009 0.3638
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0005 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0069 0.0247 0.044
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0086 0.1768
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Loa Loa (eye worm) hypothetical protein 0.0042 0.0136 0.0579
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0136 0.0579
Echinococcus multilocularis muscleblind protein 0.0294 0.1185 0.1185
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.009 0.3638
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0088 0.0088
Schistosoma mansoni sugar transporter 0.0014 0.0019 0.0033
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0108 0.094
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0069 0.0247 0.1329
Echinococcus granulosus beta LACTamase domain containing family member 0.0069 0.0247 0.044
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0018 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0158 0.0828
Schistosoma mansoni ran 0.0022 0.0051 0.009
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0019 0.0158
Loa Loa (eye worm) hypothetical protein 0.0036 0.0108 0.0458
Mycobacterium tuberculosis Conserved protein 0.0015 0.0021 0.0065
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0361
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0089 0.3606
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0213 0.0213
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0089 0.0753
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0371 0.3132
Mycobacterium tuberculosis Probable esterase LipL 0.0069 0.0247 0.1329
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0015 0.0021 0.0186
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0019 0.0033
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0088 0.0157
Onchocerca volvulus 0.0014 0.0018 0.0165
Toxoplasma gondii aldo-keto reductase 0.0015 0.0021 0.0186
Echinococcus multilocularis General substrate transporter 0.0087 0.0321 0.0321
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0051 0.0173 0.1508
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0051 0.0173 0.1457
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0213 0.038
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0046 0.1846
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Schistosoma mansoni protein kinase 0.0031 0.0088 0.0157
Loa Loa (eye worm) matrix metalloproteinase 0.0087 0.0323 0.1373
Loa Loa (eye worm) hypothetical protein 0.0051 0.0173 0.0734
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.037 0.0658
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0108 0.0458
Brugia malayi hypothetical protein 0.0014 0.0019 0.0158
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0031 0.1248
Schistosoma mansoni ran 0.0022 0.0051 0.009
Onchocerca volvulus 0.0029 0.008 0.0979
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.019 0.0339
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.019 0.1607
Mycobacterium ulcerans hypothetical protein 0.0069 0.0247 0.2153
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0051 0.0442
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0005 0.0005
Onchocerca volvulus 0.0146 0.0567 0.7399
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0108 1
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0352 0.0352
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0228 0.0406
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0005 0.0009
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0086 0.0594
Echinococcus granulosus General substrate transporter 0.0087 0.0321 0.0571
Toxoplasma gondii HEAT repeat-containing protein 0.001 0.0002 0.0017
Brugia malayi PHD-finger family protein 0.0011 0.0007 0.0062
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0051 0.0173 0.1457
Loa Loa (eye worm) hypothetical protein 0.0087 0.0323 0.1373
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0088 0.0157
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0158 0.136
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0086 0.0723
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0015 0.0021 0.0122
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.038 0.0676
Echinococcus multilocularis geminin 0.0179 0.0704 0.0704
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0019 0.0756
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0018 0.015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0076
Echinococcus granulosus aldo keto reductase 0.0051 0.0173 0.0307
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0089 0.0089
Schistosoma mansoni transient receptor potential channel 0.0064 0.0228 0.0406
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0051 0.0173 0.0307
Brugia malayi NADH-dependent xylose reductase 0.0015 0.0021 0.018
Plasmodium vivax aldehyde reductase, putative 0.0015 0.0021 0.0122
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0365 0.065
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0051 0.0173 0.0173
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0005 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0005 0.0009
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0019 0.008
Schistosoma mansoni sugar transporter 0.0014 0.0019 0.0033
Trypanosoma brucei glucose transporter, putative 0.0031 0.009 0.3638
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0046 0.0386
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0044 0.0144 0.0144
Trypanosoma brucei glucose transporter 2A 0.0031 0.009 0.3638
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0018 0.0076
Brugia malayi MH2 domain containing protein 0.0115 0.044 0.3712
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.0998 0.1777
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0213 0.1853
Schistosoma mansoni microtubule-associated protein tau 0.1359 0.562 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0019 0.0756
Loa Loa (eye worm) oxidoreductase 0.0051 0.0173 0.0734
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0039 0.056
Echinococcus multilocularis aldo keto reductase 0.0051 0.0173 0.0173
Trypanosoma brucei importin beta-1 subunit, putative 0.0054 0.0184 0.7423
Loa Loa (eye worm) hypothetical protein 0.0146 0.0567 0.2414
Loa Loa (eye worm) matrixin family protein 0.0193 0.0765 0.3254
Echinococcus multilocularis aldo keto reductase 0.0051 0.0173 0.0173
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0051 0.0173 0.1508
Plasmodium vivax hexose transporter 0.0101 0.038 0.2179
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0108 0.0617
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0005 0.0009
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0046 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0051 0.0173 0.0307
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0044 0.0144 0.0256
Trypanosoma brucei importin beta-1 subunit, putative 0.0054 0.0184 0.7423
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.008 0.008
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0089 0.3606
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0088 0.077
Giardia lamblia PHD finger protein 15 0.003 0.0085 0.0474
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0088 0.077
Echinococcus multilocularis peregrin 0.003 0.0085 0.0085
Entamoeba histolytica hypothetical protein 0.0099 0.0373 0.263
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0107 0.0611
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0158 0.0828
Echinococcus multilocularis aldehyde reductase 0.0036 0.0111 0.0111
Brugia malayi Cam kinase protein 1 0.0031 0.0088 0.0745
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.009 0.0778
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0088 0.0376
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0018 0.0045
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0213 0.186
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0099 0.0373 0.263
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0007 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0118 0.021
Trypanosoma cruzi hexose transporter 0.0031 0.009 0.3638
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0158 0.136
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0107 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.0148
Plasmodium falciparum protein kinase 6 0.0429 0.1744 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0405 0.0721
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0019 0.0756
Schistosoma mansoni ap endonuclease 0.0021 0.0046 0.0081
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0089 0.0159
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0019 0.0158
Trichomonas vaginalis D-aminoacylase, putative 0.0069 0.0247 0.2169
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0089 0.3606
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0019 0.005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0046 1
Toxoplasma gondii exonuclease III APE 0.0021 0.0046 0.0398
Mycobacterium ulcerans oxidoreductase 0.0051 0.0173 0.1492
Mycobacterium tuberculosis Probable lipase LipD 0.0069 0.0247 0.1329
Plasmodium falciparum phd finger protein, putative 0.003 0.0085 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.0148
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0108 0.094
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0005 0.0044
Brugia malayi PHD-finger family protein 0.003 0.0085 0.0716
Schistosoma mansoni glucose transport protein 0.0101 0.038 0.0676
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0085 0.0361
Loa Loa (eye worm) hypothetical protein 0.0052 0.0174 0.0741
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0158 0.1105
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0086 0.0723
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0044 0.0141 0.1231
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0018 0.0121
Echinococcus multilocularis snurportin 1 0.0574 0.2351 0.2351
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0005 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0018 0.015
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0018 0.0121
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0046 0.0386
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0214 0.0381
Mycobacterium tuberculosis Conserved protein 0.0069 0.0247 0.1329
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0405 0.0721
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0088 0.0507
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0051 0.0173 0.0173
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0018 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0018 0.0121
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0227
Leishmania major protein kinase, putative 0.0031 0.0088 0.3571
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0018 0.015
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.044 0.1871
Loa Loa (eye worm) hypothetical protein 0.0069 0.0247 0.1052
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.003 0.0086 0.0365
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0107 0.4311
Onchocerca volvulus 0.0014 0.0018 0.0165
Onchocerca volvulus Matrilysin homolog 0.0087 0.0323 0.4179
Brugia malayi jmjC domain containing protein 0.0098 0.037 0.312
Onchocerca volvulus 0.0014 0.0019 0.0177
Brugia malayi Matrixin family protein 0.0087 0.0323 0.2724
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0039 0.0165
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0088 0.3571
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0022
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0051 0.0173 0.0307
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0228 0.0406
Brugia malayi Hemopexin family protein 0.0124 0.0475 0.4005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.014 0.0542 0.4572
Toxoplasma gondii sugar transporter ST3 0.0014 0.0019 0.0163
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0136 0.0242
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0005 0.0009
Onchocerca volvulus 0.0014 0.0019 0.0177
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0046 0.0368
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0365 0.065
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0005 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0005 0.0044
Trichomonas vaginalis glucose transporter, putative 0.0031 0.009 0.0778
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0405 0.0405
Trypanosoma cruzi hexose transporter, putative 0.0031 0.009 0.3638
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0053 0.0466
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0087 0.0323 0.0574
Trypanosoma cruzi aldo/keto reductase, putative 0.0051 0.0173 0.6979
Trichomonas vaginalis aldo/keto reductase, putative 0.0051 0.0173 0.1508
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Onchocerca volvulus 0.0014 0.0018 0.0165
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Loa Loa (eye worm) glutaminase 0.0282 0.1134 0.4821
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Trypanosoma brucei glucose transporter, putative 0.0031 0.009 0.3638
Onchocerca volvulus 0.0069 0.0247 0.3186
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0001 0.0021
Onchocerca volvulus 0.0014 0.0019 0.0177
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0015 0.0021 0.0186
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.038 0.038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0005 0.0044
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Mycobacterium ulcerans esterase/lipase LipP 0.0069 0.0247 0.2153
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0051 0.0428
Trichomonas vaginalis glucose transporter, putative 0.0031 0.009 0.0778
Schistosoma mansoni glucose transporter 0.0014 0.0019 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0005 0.0022
Trichomonas vaginalis aldo-keto reductase, putative 0.0015 0.0021 0.0171
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0005 0.0009
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0051 0.0173 0.403
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.019 0.7696
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0021 0.0171
Brugia malayi hypothetical protein 0.0107 0.0405 0.3419
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0044 0.0144 0.1213
Onchocerca volvulus 0.0014 0.0019 0.0177
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.001 0.0002 0.0079
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0108 0.0193
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0005 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0031 0.009 0.0778
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0018 0.0121
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0086 0.0481
Mycobacterium ulcerans lipase LipD 0.0069 0.0247 0.2153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0005 0.0022
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0051 0.0173 0.0173
Trypanosoma cruzi hexose transporter, putative 0.0031 0.009 0.3638
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0163 0.0639 0.3664
Loa Loa (eye worm) pigment dispersing factor receptor c 0.014 0.0542 0.2304
Loa Loa (eye worm) hypothetical protein 0.0069 0.0247 0.1052
Echinococcus granulosus solute carrier family 22 0.0014 0.0019 0.0033
Schistosoma mansoni aldo-keto reductase 0.0051 0.0173 0.0307
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0005 0.0009
Brugia malayi isocitrate dehydrogenase 0.0031 0.0089 0.0753
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0018 0.0719
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Loa Loa (eye worm) hypothetical protein 0.0069 0.0247 0.1052
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Entamoeba histolytica alcohol dehydrogenase, putative 0.0015 0.0021 0.0137
Plasmodium vivax transportin, putative 0.001 0.0002 0.0011
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0053 0.216
Echinococcus multilocularis importin 5 0.001 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0044 0.0144 0.0256
Brugia malayi CHE-14 protein 0.0042 0.0136 0.1149
Toxoplasma gondii HEAT repeat-containing protein 0.0054 0.0184 0.16
Entamoeba histolytica aldose reductase, putative 0.0051 0.0173 0.121
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0018 0.0045
Schistosoma mansoni importin-beta 2 0.001 0.0002 0.0003
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0019 0.008
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0053 0.0306
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0107 0.0611
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0089 0.0777
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0108 0.0617
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0085 0.0739
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0022
Onchocerca volvulus 0.0014 0.0019 0.0177
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0046 0.0201
Plasmodium vivax CDK-related protein kinase 6, putative 0.0429 0.1744 1
Schistosoma mansoni hypothetical protein 0.0044 0.0144 0.0256
Onchocerca volvulus 0.0087 0.0323 0.4179
Echinococcus multilocularis protein dispatched 1 0.0048 0.0161 0.0161
Entamoeba histolytica protein kinase, putative 0.0031 0.0088 0.0612
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0019 0.0148
Echinococcus granulosus geminin 0.0179 0.0704 0.1253
Entamoeba histolytica hypothetical protein 0.0044 0.0141 0.0987
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0018 0.0045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0046 0.1846
Toxoplasma gondii aldose reductase, putative 0.0051 0.0173 0.1504
Plasmodium vivax hypothetical protein, conserved 0.003 0.0085 0.0486
Trichomonas vaginalis aldo/keto reductase, putative 0.0051 0.0173 0.1508
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0158 0.3644
Brugia malayi major facilitator superfamily protein 0.0014 0.0019 0.0158
Onchocerca volvulus 0.0069 0.0247 0.3186
Brugia malayi beta-lactamase 0.0069 0.0247 0.2088
Loa Loa (eye worm) oxidoreductase 0.0051 0.0173 0.0734
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0118 0.0502
Plasmodium falciparum aldo-keto reductase, putative 0.0015 0.0021 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0364 0.0648
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0213 0.1853
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0046 0.0262
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0012 0.0011 0.0048
Trypanosoma brucei glucose transporter, putative 0.0031 0.009 0.3638
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0053 0.0249
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0285 0.0508
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0019 0.0129
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0018 0.0032
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0046 0.1846
Trichomonas vaginalis sugar transporter, putative 0.0031 0.009 0.0778
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0213 0.1853
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0018 0.0121
Trichomonas vaginalis aldo/keto reductase, putative 0.0051 0.0173 0.1508
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0005 0.0005
Entamoeba histolytica Ran family GTPase 0.0022 0.0051 0.0346
Brugia malayi Muscleblind-like protein 0.0294 0.1185 1
Echinococcus granulosus aldo keto reductase 0.0051 0.0173 0.0307
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0051 0.0291
Trichomonas vaginalis aldo-keto reductase, putative 0.0015 0.0021 0.0171
Loa Loa (eye worm) kap beta 3 protein 0.001 0.0002 0.0008
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0108 0.0914
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0213 0.038
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0001 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0158 0.6379
Loa Loa (eye worm) importin-beta domain-containing protein 0.001 0.0002 0.0008
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0051 0.0173 0.0173
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0228 0.0228
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0108 0.4381
Onchocerca volvulus 0.0051 0.0173 0.2202
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0365 0.0365
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0158 0.1105
Mycobacterium tuberculosis Probable hydrolase 0.0069 0.0247 0.1329
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0053 0.0095
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0158 0.6379
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0051 0.009
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0053 0.0436
Brugia malayi ecdysteroid receptor 0.0011 0.0005 0.0044
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.0998 0.0998
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0108 0.0108
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0019 0.0107
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0069 0.0247 0.2153
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0018 0.0719
Mycobacterium ulcerans beta-lactamase 0.0069 0.0247 0.2153
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0089 0.0089
Onchocerca volvulus 0.0014 0.0019 0.0177
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0069 0.0247 0.2088
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0088 0.0507
Onchocerca volvulus 0.0051 0.0173 0.2202
Echinococcus granulosus peregrin 0.003 0.0085 0.0151
Trichomonas vaginalis esterase, putative 0.0069 0.0247 0.2169
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0051 0.2051
Schistosoma mansoni ap endonuclease 0.0021 0.0046 0.0081
Schistosoma mansoni glutaminase 0.0282 0.1134 0.2017
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0018 0.0121
Brugia malayi kap beta 3 protein 0.001 0.0002 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0018 0.0121
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0022
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0371 0.2617
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0218 0.0928
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0158 0.6379
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0018 0.0719
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0107 0.4311
Toxoplasma gondii sugar transporter ST1 0.0014 0.0019 0.0163
Mycobacterium ulcerans sugar transporter 0.0014 0.0019 0.0129
Schistosoma mansoni polycystin 1-related 0.0091 0.0339 0.0603
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Loa Loa (eye worm) hypothetical protein 0.0036 0.0108 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0005 0.0044
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0108 0.0108
Mycobacterium leprae Possible oxidoreductase 0.0015 0.0021 0.0092
Onchocerca volvulus 0.0014 0.0019 0.0177
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0005 0.0009
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0371 0.066
Onchocerca volvulus 0.0015 0.0021 0.0211
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0108 0.0193
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Echinococcus multilocularis voltage gated potassium channel subunit 0.0015 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0044 0.0144 0.0256
Echinococcus multilocularis solute carrier family 22 0.0014 0.0019 0.0019
Brugia malayi Sugar transporter family protein 0.0014 0.0019 0.0158
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.0111 0.2424
Loa Loa (eye worm) hypothetical protein 0.0036 0.0108 0.0458
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0051 0.0173 0.6979
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0053 0.0928
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0005 0.0009
Loa Loa (eye worm) oxidoreductase 0.0051 0.0173 0.0734
Loa Loa (eye worm) hypothetical protein 0.014 0.0542 0.2304
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0088 0.0507
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0158 0.136
Loa Loa (eye worm) hypothetical protein 0.0036 0.011 0.047
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0108 0.0193
Onchocerca volvulus 0.0014 0.0019 0.0177
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0051 0.0173 0.0307
Onchocerca volvulus 0.0051 0.0173 0.2202
Giardia lamblia Aldose reductase 0.0051 0.0173 0.1104
Schistosoma mansoni sugar transporter 0.0014 0.0019 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0088 0.0157
Leishmania major prostaglandin f synthase, putative 0.0051 0.0173 0.6979
Plasmodium falciparum hexose transporter 0.0101 0.038 0.2179
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0076
Brugia malayi Matrixin family protein 0.0087 0.0323 0.2724
Plasmodium vivax importin-beta 2, putative 0.0054 0.0184 0.1053
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0364 0.3073
Onchocerca volvulus Matrilysin homolog 0.0193 0.0765 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0053 0.0095
Loa Loa (eye worm) hypothetical protein 0.0099 0.0371 0.1578
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0019 0.0019
Brugia malayi Sugar transporter family protein 0.0014 0.0019 0.0158
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.038 0.3312
Brugia malayi Matrixin family protein 0.0211 0.0838 0.7071
Brugia malayi Calcitonin receptor-like protein seb-1 0.014 0.0542 0.4572
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.011 0.0197
Echinococcus multilocularis expressed conserved protein 0.0093 0.0346 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.0148
Plasmodium falciparum aldehyde reductase, putative 0.0015 0.0021 0.0122
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0089 0.0511
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0051 0.0173 0.0173
Trichomonas vaginalis penicillin-binding protein, putative 0.0069 0.0247 0.2169
Brugia malayi AF-10 protein 0.001 0.0001 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0088 0.0763
Onchocerca volvulus 0.0069 0.0247 0.3186
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0213 0.8627
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.008
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0051 0.0173 0.0307
Loa Loa (eye worm) hypothetical protein 0.0048 0.0158 0.0671
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0107 0.4311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0108 0.0458
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0376
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0088 0.0507
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0158 0.136
Trichomonas vaginalis aldo-keto reductase, putative 0.0051 0.0173 0.1508
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0051 0.2051
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0107 0.4311
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0108 0.0193
Schistosoma mansoni survival motor neuron protein 0.0051 0.0171 0.0305
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0053 0.0436
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0018 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0018 0.0121
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0134 0.0238
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0001 0.0021
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0001 0.0004
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0051 0.0173 0.0173
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0008 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0019 0.0148
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0089 0.0379
Echinococcus multilocularis solute carrier family 22 0.0014 0.0019 0.0019

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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