Detailed information for compound 1131203

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 472.615 | Formula: C31H36O4
  • H donors: 2 H acceptors: 4 LogP: 4.92 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@]2(O)c1ccc2c(c1)CC(C2)(C(=O)C)C(=O)C)C
  • InChi: 1S/C31H36O4/c1-18(32)30(19(2)33)16-21-4-6-23(14-22(21)17-30)31(35)13-11-28-27-8-5-20-15-24(34)7-9-25(20)26(27)10-12-29(28,31)3/h4,6-7,9,14-15,26-28,34-35H,5,8,10-13,16-17H2,1-3H3/t26-,27-,28+,29+,31-/m1/s1
  • InChiKey: DLSWVRDRLFHXKU-JTODZQAJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 1 Starlite/ChEMBL References
Homo sapiens estrogen receptor 2 (ER beta) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein estrogen receptor 2 (ER beta) 495 aa 418 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Protein CNPPD1 homolog 0.0047 0.0161 0.0509
Brugia malayi beta-lactamase family protein 0.0036 0.0111 0.0095
Brugia malayi fibroinase precursor 0.0248 0.1113 0.1099
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0031 0.0016
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Brugia malayi hypothetical protein 0.0019 0.0031 0.0016
Echinococcus granulosus cyclin dependent kinase 1 0.0258 0.1158 0.1153
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0031 0.0026
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0022 0.0006
Trypanosoma cruzi mitotic cyclin, putative 0.0047 0.0161 0.012
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0047 0.0161 0.0131
Schistosoma mansoni smad1 5 8 and 0.0016 0.0016 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.1113 0.122
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0113 0.0107
Giardia lamblia Cysteine protease 0.0248 0.1113 0.1063
Brugia malayi Cyclin, N-terminal domain containing protein 0.0342 0.1556 0.1543
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0111 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0113 0.0097
Leishmania major cyclin 0.0342 0.1556 0.1668
Trypanosoma cruzi cyclin 9, putative 0.0047 0.0161 0.012
Entamoeba histolytica cysteine proteinase, putative 0.039 0.1781 0.6232
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0248 0.1113 0.1108
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1943 0.9122 1
Echinococcus multilocularis cyclin y 0.0047 0.0161 0.0155
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0113 0.0107
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0111 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0248 0.1113 0.122
Schistosoma mansoni smad1 5 8 and 0.0016 0.0016 0.001
Brugia malayi Cyclin, N-terminal domain containing protein 0.0047 0.0161 0.0145
Brugia malayi Doublecortin family protein 0.0101 0.0416 0.04
Plasmodium vivax cyclin homologue, putative 0.0047 0.0161 0.019
Loa Loa (eye worm) hypothetical protein 0.0101 0.0416 0.04
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0248 0.1113 0.3784
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0113 0.0334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2761 0.2994
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1057 0.1042
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0111 0.0121
Brugia malayi tailless protein 0.0017 0.0022 0.0006
Brugia malayi Cytochrome P450 family protein 0.0075 0.0295 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0113 0.0097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0248 0.1113 0.1108
Giardia lamblia Cathepsin B precursor 0.0248 0.1113 0.1063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0113 0.0107
Toxoplasma gondii hypothetical protein 0.0147 0.0636 0.0654
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0248 0.1113 0.122
Echinococcus granulosus Smad4 0.0016 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0097
Entamoeba histolytica cell division protein kinase 2, putative 0.0258 0.1158 0.3835
Loa Loa (eye worm) cyclin domain-containing protein 0.0047 0.0161 0.0145
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0161 0.019
Loa Loa (eye worm) cytochrome P450 0.0022 0.0042 0.0026
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0113 0.0097
Brugia malayi MH2 domain containing protein 0.0236 0.1057 0.1042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0097
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0248 0.1113 0.1099
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0022 0.0016
Toxoplasma gondii cathepsin CPC1 0.0248 0.1113 0.118
Trypanosoma cruzi cysteine peptidase, putative 0.039 0.1781 0.1747
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0113 0.0097
Plasmodium falciparum serine repeat antigen 2 0.0248 0.1113 0.3664
Trichomonas vaginalis cyclin B3, putative 0.0047 0.0161 0.0177
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0075 0.0295 0.5709
Brugia malayi Cyclin C 0.0047 0.0161 0.0145
Brugia malayi hypothetical protein 0.0019 0.0031 0.0016
Leishmania major cathepsin L-like protease 0.0597 0.2761 0.2994
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0111 0.0696
Loa Loa (eye worm) hypothetical protein 0.0456 0.2093 0.208
Onchocerca volvulus 0.0036 0.0111 0.0326
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.039 0.1781 0.1776
Echinococcus multilocularis Smad4 0.0016 0.0016 0.001
Trichomonas vaginalis cyclins, putative 0.0342 0.1556 0.1706
Schistosoma mansoni cyclin G2 0.0047 0.0161 0.0155
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0016 0.001
Giardia lamblia Hypothetical protein 0.0248 0.1113 0.1063
Onchocerca volvulus 0.0597 0.2761 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0248 0.1113 0.122
Brugia malayi Cyclin, N-terminal domain containing protein 0.0047 0.0161 0.0145
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0047 0.0161 0.0155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2761 0.3026
Brugia malayi Cyclin, N-terminal domain containing protein 0.0047 0.0161 0.0145
Onchocerca volvulus 0.0597 0.2761 1
Giardia lamblia Hypothetical protein 0.0194 0.0857 0.0776
Brugia malayi beta-lactamase family protein 0.0036 0.0111 0.0095
Trypanosoma cruzi cysteine peptidase, putative 0.0597 0.2761 0.273
Loa Loa (eye worm) fibroinase 0.0597 0.2761 0.2749
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2761 0.2994
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0248 0.1113 0.3784
Brugia malayi nuclear hormone receptor 0.0037 0.0113 0.0097
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.0444 0.0443
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0016 0.001
Onchocerca volvulus 0.0101 0.0416 0.1439
Echinococcus granulosus cathepsin b 0.2129 1 1
Echinococcus multilocularis cyclin 0.0047 0.0161 0.0155
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0113 0.0107
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0113 0.0107
Brugia malayi cell division control protein 2 homolog 0.0258 0.1158 0.1144
Plasmodium vivax vivapain-1 0.039 0.1781 0.6304
Trypanosoma cruzi major cysteine proteinase, putative 0.0248 0.1113 0.1076
Trypanosoma cruzi CYC2-like cyclin, putative 0.0342 0.1556 0.1521
Schistosoma mansoni cathepsin C 0.0248 0.1113 0.1108
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0113 0.0097
Brugia malayi Cytochrome P450 family protein 0.0075 0.0295 0.0279
Schistosoma mansoni Smad4 0.0016 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0095
Onchocerca volvulus 0.0036 0.0111 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0113 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0115 0.0485 0.0479
Plasmodium falciparum serine repeat antigen 8 0.0248 0.1113 0.3664
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0113 0.0107
Echinococcus multilocularis cyclin y 0.0047 0.0161 0.0155
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0248 0.1113 0.1108
Loa Loa (eye worm) hypothetical protein 0.0248 0.1113 0.1099
Plasmodium vivax vivapain-3 0.039 0.1781 0.6304
Trypanosoma brucei cyclin 3 0.0047 0.0161 0.0131
Echinococcus multilocularis cyclins 0.0194 0.0857 0.0852
Trichomonas vaginalis cyclins, putative 0.0194 0.0857 0.0939
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0022 0.0016
Echinococcus multilocularis cyclin dependent kinase 1 0.0258 0.1158 0.1153
Brugia malayi cathepsin F-like cysteine proteinase 0.0248 0.1113 0.1099
Brugia malayi follicle stimulating hormone receptor 0.0696 0.3229 0.3218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0248 0.1113 0.122
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0113 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0113 0.0107
Brugia malayi Cathepsin L-like precursor 0.0597 0.2761 0.2749
Brugia malayi nuclear receptor NHR-88 0.0017 0.0022 0.0006
Onchocerca volvulus 0.0597 0.2761 1
Onchocerca volvulus 0.0101 0.0416 0.1439
Trypanosoma brucei cysteine peptidase C (CPC) 0.1943 0.9122 1
Leishmania major cathepsin L-like protease 0.0597 0.2761 0.2994
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0248 0.1113 0.1063
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0456 0.2093 0.206
Onchocerca volvulus 0.0248 0.1113 0.3986
Schistosoma mansoni serine/threonine protein kinase 0.0258 0.1158 0.1153
Brugia malayi Cathepsin L-like precursor 0.0456 0.2093 0.208
Echinococcus multilocularis cpg binding protein 0.006 0.0221 0.0215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Entamoeba histolytica cysteine proteinase 2 0.039 0.1781 0.6232
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0022 0.0016
Toxoplasma gondii hypothetical protein 0.0047 0.0161 0.0131
Onchocerca volvulus Cathepsin L homolog 0.0248 0.1113 0.3986
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0022 0.0016
Schistosoma mansoni cpg binding protein 0.006 0.0221 0.0215
Echinococcus granulosus Polycystic kidney disease protein 0.0101 0.0416 0.041
Trichomonas vaginalis cyclin B, putative 0.0342 0.1556 0.1706
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0248 0.1113 0.1063
Brugia malayi Cyclin, N-terminal domain containing protein 0.0047 0.0161 0.0145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Trichomonas vaginalis cyclin D, putative 0.0194 0.0857 0.0939
Loa Loa (eye worm) hypothetical protein 0.0141 0.0607 0.0593
Leishmania major mitotic cyclin, putative 0.0047 0.0161 0.0131
Trichomonas vaginalis cyclins, putative 0.0342 0.1556 0.1706
Trypanosoma cruzi cysteine protease, putative 0.039 0.1781 0.1747
Echinococcus multilocularis cyclin k 0.0047 0.0161 0.0155
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.039 0.1781 0.1776
Entamoeba histolytica cysteine proteinase, putative 0.039 0.1781 0.6232
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0248 0.1113 0.122
Giardia lamblia Cathepsin B precursor 0.0248 0.1113 0.1063
Trichomonas vaginalis cyclins, putative 0.0195 0.086 0.0943
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0295 0.0279
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0141 0.0607 0.0593
Trichomonas vaginalis cyclin B, putative 0.0342 0.1556 0.1706
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0095
Brugia malayi conserved hypotetical protein 0.0017 0.0022 0.0006
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0248 0.1113 0.3664
Loa Loa (eye worm) hypothetical protein 0.0248 0.1113 0.1099
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0111 0.0696
Schistosoma mansoni cathepsin S (C01 family) 0.0248 0.1113 0.1108
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0022 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0161 0.0177
Plasmodium falciparum serine repeat antigen 6 0.0248 0.1113 0.3664
Echinococcus granulosus cathepsin L 0.0248 0.1113 0.1108
Schistosoma mansoni smad1 5 8 and 0.0016 0.0016 0.001
Plasmodium vivax vivapain-2 0.0597 0.2761 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0111 0.0121
Giardia lamblia Cathepsin L precursor 0.0248 0.1113 0.1063
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0141 0.0607 0.0593
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0113 0.0097
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0022 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.0597 0.2761 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0111 0.0696
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0031 0.0026
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0248 0.1113 0.1108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0113 0.0097
Echinococcus granulosus RUN 0.0101 0.0416 0.041
Plasmodium vivax unspecified product 0.039 0.1781 0.6304
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0111 0.0069
Brugia malayi cathepsin L-like cysteine proteinase 0.0248 0.1113 0.1099
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0113 0.0097
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.0485 0.0469
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0248 0.1113 0.122
Echinococcus granulosus cyclin t1 0.0047 0.0161 0.0155
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0031 0.0016
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0022 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0113 0.0107
Echinococcus multilocularis lipoxygenase domain containing protein 0.0101 0.0416 0.041
Trypanosoma cruzi cysteine peptidase, putative 0.0597 0.2761 0.273
Loa Loa (eye worm) cyclin domain-containing protein 0.0047 0.0161 0.0145
Echinococcus granulosus cyclin G2 0.0047 0.0161 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0113 0.0097
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0111 0.0696
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0258 0.1158 0.1144
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0115 0.0485 0.0488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0456 0.2093 0.2294
Onchocerca volvulus 0.0456 0.2093 0.7562
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0031 0.0026
Plasmodium falciparum serine repeat antigen 7 0.0248 0.1113 0.3664
Echinococcus granulosus cyclin b3 0.0194 0.0857 0.0852
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0016
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0597 0.2761 1
Schistosoma mansoni polycystin 1-related 0.0101 0.0416 0.041
Schistosoma mansoni cyclin k 0.0047 0.0161 0.0155
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0097
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0047 0.0161 0.019
Loa Loa (eye worm) cathepsin B 0.1943 0.9122 0.9121
Brugia malayi Cathepsin L-like precursor 0.0597 0.2761 0.2749
Onchocerca volvulus 0.0597 0.2761 1
Echinococcus multilocularis cathepsin L 0.039 0.1781 0.1776
Entamoeba histolytica hypothetical protein 0.0248 0.1113 0.3664
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0113 0.0107
Plasmodium falciparum protein kinase 5 0.0258 0.1158 0.3835
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0095
Giardia lamblia Kinase, CMGC CDK 0.0258 0.1158 0.1112
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0016
Entamoeba histolytica cysteine protease, putative 0.0248 0.1113 0.3664
Loa Loa (eye worm) hypothetical protein 0.0342 0.1556 0.1543
Echinococcus multilocularis cathepsin L cysteine protease 0.0597 0.2761 0.2756
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0021 0.0005
Leishmania major cathepsin L-like protease 0.0597 0.2761 0.2994
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0597 0.2761 0.3026
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0111 0.0696
Loa Loa (eye worm) ctsf protein 0.0597 0.2761 0.2749
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0113 0.0097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2761 0.3026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2761 0.2994
Echinococcus multilocularis cyclin B3 1 0.0194 0.0857 0.0852
Echinococcus granulosus cathepsin l1 0.0456 0.2093 0.2088
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0113 0.0334
Brugia malayi hypothetical protein 0.0047 0.0161 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.1113 0.122
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0248 0.1113 0.1099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Echinococcus granulosus cyclins 0.0047 0.0161 0.0155
Trichomonas vaginalis cyclins, putative 0.0047 0.0161 0.0177
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0022 0.0016
Brugia malayi cyclin fold protein 1 variant b 0.0047 0.0161 0.0145
Giardia lamblia Cathepsin L precursor 0.0248 0.1113 0.1063
Trypanosoma cruzi cdc2-related kinase 3 0.0258 0.1158 0.1121
Entamoeba histolytica cysteine protease, putative 0.0248 0.1113 0.3664
Schistosoma mansoni cathepsin B (C01 family) 0.0248 0.1113 0.1108
Loa Loa (eye worm) cyclin domain-containing protein 0.0047 0.0161 0.0145
Loa Loa (eye worm) hypothetical protein 0.0248 0.1113 0.1099
Schistosoma mansoni cathepsin F (C01 family) 0.0597 0.2761 0.2756
Echinococcus multilocularis cyclin dependent kinase 0.0258 0.1158 0.1153
Giardia lamblia Cathepsin B precursor 0.1943 0.9122 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0095
Trichomonas vaginalis esterase, putative 0.0036 0.0111 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.039 0.1781 0.1915
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0113 0.0097
Mycobacterium tuberculosis Conserved protein 0.0036 0.0111 0.0696
Brugia malayi cathepsin L-like precursor 0.0456 0.2093 0.208
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0047 0.0161 0.0131
Schistosoma mansoni coup transcription factor 0.0037 0.0113 0.0107
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0042 0.0026
Giardia lamblia Cathepsin L precursor 0.0248 0.1113 0.1063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.039 0.1781 0.1952
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0111 0.1556
Loa Loa (eye worm) hypothetical protein 0.0148 0.0639 0.0624
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0047 0.0161 0.0145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0248 0.1113 0.1063
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.1113 0.122
Echinococcus multilocularis cyclin t1 0.0047 0.0161 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0248 0.1113 0.122
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2129 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0097
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0248 0.1113 0.3664
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0113 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0258 0.1158 0.1153
Echinococcus granulosus cathepsin b 0.2129 1 1
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Echinococcus multilocularis RUN 0.0101 0.0416 0.041
Mycobacterium tuberculosis Conserved protein 0.0036 0.0111 0.0696
Echinococcus multilocularis 0.0022 0.0042 0.0036
Onchocerca volvulus 0.0036 0.0111 0.0326
Trypanosoma brucei cdc2-related kinase 1 0.0258 0.1158 0.1229
Schistosoma mansoni Cyclin fold protein 0.0047 0.0161 0.0155
Brugia malayi hypothetical protein 0.0017 0.0022 0.0006
Plasmodium vivax cyclin 4, putative 0.0047 0.0161 0.019
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0258 0.1158 0.1153
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0248 0.1113 0.1099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0113 0.0097
Trichomonas vaginalis cyclin B, putative 0.0047 0.0161 0.0177
Giardia lamblia Cathepsin L precursor 0.0248 0.1113 0.1063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Loa Loa (eye worm) cyclin domain-containing protein 0.0047 0.0161 0.0145
Echinococcus multilocularis G1:S specific cyclin D1 0.0047 0.0161 0.0155
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Plasmodium falciparum serine repeat antigen 9 0.0248 0.1113 0.3664
Plasmodium falciparum serine repeat antigen 1 0.0248 0.1113 0.3664
Loa Loa (eye worm) cyclin domain-containing protein 0.0047 0.0161 0.0145
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0031 0.0016
Mycobacterium ulcerans hypothetical protein 0.0036 0.0111 0.1556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2761 0.2994
Echinococcus multilocularis cyclin b3 0.0194 0.0857 0.0852
Echinococcus granulosus cyclin dependent kinase 5 0.0258 0.1158 0.1153
Echinococcus multilocularis lipoxygenase domain containing protein 0.0101 0.0416 0.041
Giardia lamblia Cathepsin L precursor 0.0248 0.1113 0.1063
Leishmania major cyclin 9, putative 0.0047 0.0161 0.0131
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0597 0.2761 1
Entamoeba histolytica cysteine protease, putative 0.0248 0.1113 0.3664
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0258 0.1158 0.1229
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Onchocerca volvulus 0.0597 0.2761 1
Trichomonas vaginalis cyclin B3, putative 0.0194 0.0857 0.0939
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.3722 0.3718
Schistosoma mansoni cyclin G 0.0047 0.0161 0.0155
Echinococcus granulosus cpg binding protein 0.006 0.0221 0.0215
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0248 0.1113 0.1108
Brugia malayi Papain family cysteine protease containing protein 0.039 0.1781 0.1768
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0022 0.0006
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Giardia lamblia Encystation-specific protease 0.0248 0.1113 0.1063
Brugia malayi Papain family cysteine protease containing protein 0.0248 0.1113 0.1099
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0248 0.1113 0.3664
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2129 1 1
Trichomonas vaginalis cyclin B, putative 0.0194 0.0857 0.0939
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2761 0.3026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0111 0.1556
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0113 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0248 0.1113 0.122
Brugia malayi steroid hormone receptor 0.0037 0.0113 0.0097
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0113 0.0097
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0248 0.1113 0.3784
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0113 0.0097
Schistosoma mansoni rab6-interacting 0.0101 0.0416 0.041
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0113 0.0097
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0597 0.2761 0.2749
Brugia malayi ecdysone receptor 0.0017 0.0022 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.0504 0.0498
Trichomonas vaginalis cyclin D, putative 0.0047 0.0161 0.0177
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0042 0.0036
Entamoeba histolytica cyclin family protein 0.0194 0.0857 0.2677
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0022 0.0016
Leishmania major cytochrome p450-like protein 0.0075 0.0295 0.0278
Plasmodium vivax vivapain-2 0.0597 0.2761 1
Plasmodium falciparum cyclin 0.0194 0.0857 0.2677
Schistosoma mansoni zinc finger protein 0.0017 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0254 0.1139 0.1125
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0113 0.0107
Echinococcus multilocularis cyclins 0.0194 0.0857 0.0852
Giardia lamblia Cysteine protease 0.0248 0.1113 0.1063
Trichomonas vaginalis CMGC family protein kinase 0.0258 0.1158 0.1269
Brugia malayi hypothetical protein 0.0047 0.0161 0.0145
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2761 0.3026
Echinococcus granulosus cyclin B 0.0342 0.1556 0.1551
Trypanosoma cruzi cdc2-related kinase 1 0.0258 0.1158 0.1121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0342 0.1556 0.1543
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0248 0.1113 0.3784
Echinococcus granulosus cathepsin L 0.039 0.1781 0.1776
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0113 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0248 0.1113 0.122
Brugia malayi Protein kinase domain containing protein 0.0258 0.1158 0.1144
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0113 0.0107
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0248 0.1113 0.3784
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0248 0.1113 0.3784
Brugia malayi nuclear hormone receptor 0.0017 0.0022 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0111 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0113 0.0097
Loa Loa (eye worm) hypothetical protein 0.2129 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.0607 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0161 0.012
Schistosoma mansoni nuclear receptor 0.0017 0.0022 0.0016
Echinococcus multilocularis cathepsin b 0.2129 1 1
Giardia lamblia Kinase, CMGC CDK 0.0258 0.1158 0.1112
Loa Loa (eye worm) hypothetical protein 0.0456 0.2093 0.208
Echinococcus granulosus cathepsin L cysteine protease 0.039 0.1781 0.1776
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Entamoeba histolytica cyclin, putative 0.0194 0.0857 0.2677
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0111 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0113 0.0097
Trypanosoma cruzi major cysteine proteinase, putative 0.0248 0.1113 0.1076
Schistosoma mansoni lipoxygenase 0.0471 0.2165 0.216
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0248 0.1113 0.122
Brugia malayi beta-lactamase 0.0036 0.0111 0.0095
Trypanosoma brucei cytochrome P450, putative 0.0075 0.0295 0.0278
Schistosoma mansoni cathepsin s 0.0141 0.0607 0.0602
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0113 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0248 0.1113 0.122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Brugia malayi cytochrome P450 0.0022 0.0042 0.0026
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0597 0.2761 0.2756
Loa Loa (eye worm) hypothetical protein 0.0597 0.2761 0.2749
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Schistosoma mansoni loxhd1 0.0101 0.0416 0.041
Onchocerca volvulus Cathepsin L homolog 0.0597 0.2761 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.1032 1
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0113 0.0107
Schistosoma mansoni g1/s-specific cyclin C 0.0047 0.0161 0.0155
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0206 0.019
Plasmodium falciparum serine repeat antigen 4 0.0248 0.1113 0.3664
Trichomonas vaginalis cyclin D, putative 0.0194 0.0857 0.0939
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0248 0.1113 0.1108
Loa Loa (eye worm) cyclin C 0.0047 0.0161 0.0145
Echinococcus multilocularis cyclin dependent kinase 1 0.0258 0.1158 0.1153
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0113 0.0107
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0471 0.2165 0.216
Onchocerca volvulus 0.0342 0.1556 0.5603
Toxoplasma gondii cathepsin CPL 0.0597 0.2761 0.2994
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0113 0.0097
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0031 0.0026
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0022 0.0006
Echinococcus multilocularis cyclins 0.0194 0.0857 0.0852
Brugia malayi nuclear receptor RXR 0.0019 0.0031 0.0016
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.039 0.1781 0.1747
Trichomonas vaginalis cyclins, putative 0.0342 0.1556 0.1706
Brugia malayi Cathepsin L-like precursor 0.0456 0.2093 0.208
Brugia malayi cathepsin F-like cysteine proteinase 0.0141 0.0607 0.0593
Mycobacterium leprae Probable lipase LipE 0.0036 0.0111 1
Trypanosoma brucei cdc2-related kinase 3 0.0258 0.1158 0.1229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Echinococcus granulosus cyclins 0.0194 0.0857 0.0852
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0022 0.0016
Echinococcus multilocularis cysteine protease 0.0597 0.2761 0.2756
Schistosoma mansoni cathepsin F (C01 family) 0.0456 0.2093 0.2088
Toxoplasma gondii cyclin 4, putative 0.0047 0.0161 0.0131
Trichomonas vaginalis cyclins, putative 0.0342 0.1556 0.1706
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0248 0.1113 0.1108
Echinococcus multilocularis cysteine protease 0.0597 0.2761 0.2756
Brugia malayi Cyclin, N-terminal domain containing protein 0.0047 0.0161 0.0145
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0248 0.1113 0.1108
Loa Loa (eye worm) DR-78 0.0017 0.0022 0.0006
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0047 0.0161 0.0131
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Echinococcus multilocularis Polycystic kidney disease protein 0.0101 0.0416 0.041
Echinococcus granulosus G1:S specific cyclin D1 0.0047 0.0161 0.0155
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Echinococcus granulosus lipoxygenase domain containing protein 0.0101 0.0416 0.041
Entamoeba histolytica cysteine protease, putative 0.0597 0.2761 1
Giardia lamblia Cathepsin L precursor 0.0248 0.1113 0.1063
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0113 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.1113 0.122
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0111 0.0121
Loa Loa (eye worm) hypothetical protein 0.0248 0.1113 0.1099
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0047 0.0161 0.0155
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0111 0.0696
Echinococcus granulosus cathepsin L cysteine proteinase 0.0597 0.2761 0.2756
Entamoeba histolytica cyclin, putative 0.0342 0.1556 0.5367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2761 0.3026
Schistosoma mansoni cpg binding protein 0.006 0.0221 0.0215
Giardia lamblia Cathepsin B precursor 0.1943 0.9122 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0248 0.1113 0.3784
Trypanosoma cruzi cytochrome P450, putative 0.0075 0.0295 0.0254
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0111 0.0105
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0597 0.2761 0.2756
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0248 0.1113 0.1063
Leishmania major cathepsin L-like protease 0.0597 0.2761 0.2994
Giardia lamblia G2/mitotic-specific cyclin B 0.0342 0.1556 0.1557
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0016
Brugia malayi Cytochrome P450 family protein 0.0022 0.0042 0.0026
Plasmodium vivax serine-repeat antigen (SERA) 0.0248 0.1113 0.3784
Echinococcus multilocularis cyclin G2 0.0047 0.0161 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0113 0.0097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2129 1 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.0485 0.0479
Giardia lamblia Cathepsin L-like protease 0.0248 0.1113 0.1063
Schistosoma mansoni hypothetical protein 0.0398 0.182 0.1816
Echinococcus granulosus cathepsin l1 0.0597 0.2761 0.2756
Schistosoma mansoni cyclin B3 0.0304 0.1375 0.137
Mycobacterium tuberculosis Conserved protein 0.0036 0.0111 0.0696
Schistosoma mansoni hypothetical protein 0.0101 0.0416 0.041
Entamoeba histolytica cysteine proteinase, putative 0.0456 0.2093 0.7431
Trichomonas vaginalis CMGC family protein kinase 0.0258 0.1158 0.1269
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0016 0.001
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1943 0.9122 0.9119
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0022 0.0006
Trichomonas vaginalis cyclin B, putative 0.0047 0.0161 0.0177
Trypanosoma cruzi cruzipain precursor, putative 0.0141 0.0607 0.0568
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0304 0.1375 0.137
Leishmania major cathepsin L-like protease 0.0597 0.2761 0.2994
Echinococcus granulosus cyclins 0.0194 0.0857 0.0852
Brugia malayi ecdysteroid receptor 0.0037 0.0113 0.0097
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0111 0.0076
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0022 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.039 0.1781 0.6232
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0111 0.0095
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0248 0.1113 0.3664
Giardia lamblia Cathepsin L-like protease 0.0248 0.1113 0.1063
Loa Loa (eye worm) doublecortin family protein 0.0101 0.0416 0.04
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1057 0.1042
Loa Loa (eye worm) hypothetical protein 0.0141 0.0607 0.0593
Echinococcus granulosus cyclins 0.0194 0.0857 0.0852
Loa Loa (eye worm) hypothetical protein 0.0248 0.1113 0.1099
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0113 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2761 0.3026
Plasmodium vivax unspecified product 0.0141 0.0607 0.1875
Schistosoma mansoni cyclins 0.0194 0.0857 0.0852
Schistosoma mansoni cathepsin F (C01 family) 0.0597 0.2761 0.2756
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0022 0.0006
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0022 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2761 0.2994
Brugia malayi hypothetical protein 0.0017 0.0022 0.0006
Echinococcus multilocularis cathepsin L cysteine protease 0.0597 0.2761 0.2756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.1113 0.122
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1943 0.9122 1
Trypanosoma cruzi cysteine proteinase, putative 0.039 0.1781 0.1747
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Brugia malayi hypothetical protein 0.0101 0.0416 0.04
Loa Loa (eye worm) cyclin domain-containing protein 0.0047 0.0161 0.0145
Schistosoma mansoni rab6-interacting 0.0101 0.0416 0.041
Echinococcus granulosus cyclins 0.0194 0.0857 0.0852
Onchocerca volvulus Cyclin L homolog 0.0047 0.0161 0.0509
Trichomonas vaginalis cyclin B3, putative 0.0047 0.0161 0.0177
Trypanosoma cruzi cyclin 6, putative 0.0342 0.1556 0.1521
Toxoplasma gondii ABC1 family protein 0.0036 0.0111 0.0076
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0022 0.0016
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0471 0.2165 0.216
Giardia lamblia Hypothetical protein 0.0248 0.1113 0.1063
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0022 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0161 0.0177
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0113 0.0107
Onchocerca volvulus 0.0047 0.0161 0.0509
Echinococcus multilocularis cyclin B 0.0342 0.1556 0.1551
Entamoeba histolytica cysteine protease, putative 0.0248 0.1113 0.3664
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0047 0.0161 0.0155
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0342 0.1556 0.1668
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0248 0.1113 0.3784
Trichomonas vaginalis cyclins, putative 0.0047 0.0161 0.0177
Brugia malayi cathepsin Z-like cysteine proteinase 0.0248 0.1113 0.1099
Leishmania major hypothetical protein, conserved 0.0036 0.0111 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.039 0.1781 0.1915
Trypanosoma cruzi cruzipain precursor, putative 0.0597 0.2761 0.273
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.0485 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0111 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0115 0.0485 0.4471
Trypanosoma cruzi cyclin, putative 0.0342 0.1556 0.1521
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0248 0.1113 0.3784
Echinococcus multilocularis cyclins 0.0194 0.0857 0.0852
Plasmodium falciparum cysteine proteinase falcipain 3 0.0597 0.2761 1
Onchocerca volvulus Cathepsin L homolog 0.0597 0.2761 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0607 0.0593
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0022 0.0016
Echinococcus granulosus cyclin k 0.0047 0.0161 0.0155
Toxoplasma gondii cathepsin CPC2 0.0248 0.1113 0.118
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0113 0.0107
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0111 0.0105
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2129 1 1
Schistosoma mansoni nuclear receptor 0.0017 0.0022 0.0016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0248 0.1113 0.1108
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0857 0.0939
Plasmodium falciparum serine repeat antigen 5 0.0248 0.1113 0.3664
Echinococcus granulosus Cyclin L1 0.0047 0.0161 0.0155
Brugia malayi nuclear receptor NHR-67 0.0017 0.0022 0.0006
Brugia malayi cathepsin Z-like cysteine proteinase 0.0248 0.1113 0.1099
Echinococcus granulosus cyclin y 0.0047 0.0161 0.0155
Trichomonas vaginalis cyclin A, putative 0.0047 0.0161 0.0177
Trichomonas vaginalis cyclin B, putative 0.0342 0.1556 0.1706
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0047 0.0161 0.0155
Plasmodium vivax unspecified product 0.0248 0.1113 0.3784
Trypanosoma cruzi cyclin, putative 0.0342 0.1556 0.1521
Echinococcus granulosus cyclins 0.0194 0.0857 0.0852
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2761 0.2994
Trypanosoma cruzi cysteine peptidase, putative 0.0597 0.2761 0.273
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0053 0.0192 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2761 0.3026
Loa Loa (eye worm) hypothetical protein 0.0047 0.0161 0.0145
Brugia malayi Cathepsin L-like precursor 0.0597 0.2761 0.2749
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0113 0.0107
Schistosoma mansoni hypothetical protein 0.0022 0.0042 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.1113 0.122
Loa Loa (eye worm) CYL-1 protein 0.0047 0.0161 0.0145
Trypanosoma cruzi cysteine proteinase, putative 0.039 0.1781 0.1747
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0248 0.1113 0.1099
Onchocerca volvulus 0.0056 0.0206 0.0673
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0113 0.0097
Brugia malayi Cyclin, N-terminal domain containing protein 0.0342 0.1556 0.1543
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2761 0.2994
Trypanosoma cruzi cysteine peptidase, putative 0.0597 0.2761 0.273
Schistosoma mansoni cyclin d 0.0047 0.0161 0.0155
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0113 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Schistosoma mansoni lipoxygenase 0.029 0.1309 0.1304
Entamoeba histolytica cysteine protease, putative 0.0248 0.1113 0.3664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Brugia malayi Cytochrome P450 family protein 0.0022 0.0042 0.0026
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0108 0.0448 0.0433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0456 0.2093 0.2294
Toxoplasma gondii preprocathepsin c precursor, putative 0.0248 0.1113 0.118
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0113 0.0334
Echinococcus multilocularis cathepsin L 0.0248 0.1113 0.1108
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Trypanosoma cruzi cdc2-related kinase 3 0.0258 0.1158 0.1121
Entamoeba histolytica cysteine proteinase, putative 0.0597 0.2761 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0258 0.1158 0.1229
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0248 0.1113 0.3664
Echinococcus multilocularis cyclin dependent kinase 5 0.0258 0.1158 0.1153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2761 0.2994
Echinococcus granulosus cyclin A3 4 0.0047 0.0161 0.0155
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0095
Plasmodium falciparum serine repeat antigen 3 0.0248 0.1113 0.3664
Brugia malayi CXXC zinc finger family protein 0.0056 0.0206 0.019
Trichomonas vaginalis cyclin B, putative 0.0342 0.1556 0.1706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0248 0.1113 0.1099
Brugia malayi Cyclin, N-terminal domain containing protein 0.0304 0.1375 0.1361
Brugia malayi Papain family cysteine protease containing protein 0.0248 0.1113 0.1099
Echinococcus granulosus cyclin B3 1 0.0194 0.0857 0.0852
Leishmania major cysteine peptidase A (CPA) 0.0597 0.2761 0.2994
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2761 0.3026
Echinococcus granulosus lipoxygenase domain containing protein 0.0101 0.0416 0.041
Trypanosoma cruzi mitotic cyclin, putative 0.0047 0.0161 0.012
Echinococcus granulosus cyclin y 0.0047 0.0161 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0113 0.0097
Brugia malayi Papain family cysteine protease containing protein 0.039 0.1781 0.1768
Trypanosoma brucei mitotic cyclin 6 0.0342 0.1556 0.1668
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.0485 1
Toxoplasma gondii cyclin dependent kinase binding protein 0.0047 0.0161 0.0131
Entamoeba histolytica cysteine protease, putative 0.0248 0.1113 0.3664
Echinococcus granulosus smad 0.0016 0.0016 0.001
Entamoeba histolytica cyclin family protein 0.0194 0.0857 0.2677
Echinococcus multilocularis cyclin G2 0.0047 0.0161 0.0155
Echinococcus granulosus cysteine protease 0.039 0.1781 0.1776
Loa Loa (eye worm) hypothetical protein 0.0456 0.2093 0.208
Brugia malayi nuclear receptor RXR 0.0017 0.0022 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.039 0.1781 0.1952
Giardia lamblia Cathepsin B precursor 0.0248 0.1113 0.1063
Onchocerca volvulus 0.0037 0.0113 0.0334
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.0485 0.0479
Trypanosoma cruzi cytochrome P450, putative 0.0075 0.0295 0.0254
Brugia malayi Cyclin, N-terminal domain containing protein 0.0047 0.0161 0.0145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0113 0.0107
Echinococcus multilocularis cyclins 0.0194 0.0857 0.0852
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0113 0.0107
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0113 0.0107
Leishmania major cathepsin L-like protease 0.0597 0.2761 0.2994
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0113 0.0107
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0597 0.2761 0.2749
Schistosoma mansoni hypothetical protein 0.0047 0.0161 0.0155
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0095
Schistosoma mansoni cyclin B 0.0342 0.1556 0.1551
Loa Loa (eye worm) hypothetical protein 0.0047 0.0161 0.0145
Loa Loa (eye worm) cyclin domain-containing protein 0.0304 0.1375 0.1361
Onchocerca volvulus 0.0597 0.2761 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2761 0.2994
Entamoeba histolytica cysteine proteinase, putative 0.039 0.1781 0.6232
Giardia lamblia Cathepsin B precursor 0.0248 0.1113 0.1063
Onchocerca volvulus 0.0597 0.2761 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Loa Loa (eye worm) hypothetical protein 0.0101 0.0416 0.04
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0597 0.2761 0.3026
Echinococcus multilocularis cathepsin b 0.2129 1 1
Plasmodium falciparum LCCL domain-containing protein 0.0101 0.0416 0.0979
Leishmania major mitotic cyclin, putative 0.0047 0.0161 0.0131
Brugia malayi Cathepsin L-like precursor 0.0141 0.0607 0.0593
Brugia malayi Cathepsin L-like precursor 0.0597 0.2761 0.2749
Giardia lamblia Cathepsin B precursor 0.0248 0.1113 0.1063
Echinococcus granulosus cyclin dependent kinase 0.0258 0.1158 0.1153
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0161 0.0177
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0022 0.0016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1943 0.9122 0.9122
Giardia lamblia Cyclin A 0.0194 0.0857 0.0776
Brugia malayi Cathepsin L-like cysteine proteinase 0.0456 0.2093 0.208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2761 0.3026
Onchocerca volvulus Cyclin L homolog 0.0047 0.0161 0.0509
Entamoeba histolytica cysteine proteinase 1, putative 0.039 0.1781 0.6232
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0113 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0022 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0295 0.0279
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0016
Echinococcus multilocularis cyclins 0.0194 0.0857 0.0852
Schistosoma mansoni cytochrome P450 0.0022 0.0042 0.0036
Echinococcus granulosus dnaJ subfamily B 0.0398 0.182 0.1816
Echinococcus granulosus cyclin 0.0047 0.0161 0.0155
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0022 0.0016
Plasmodium vivax serine-repeat antigen (SERA) 0.0248 0.1113 0.3784
Echinococcus multilocularis smad 0.0016 0.0016 0.001
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0258 0.1158 0.1229
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0111 0.0696
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0258 0.1158 0.1144
Mycobacterium ulcerans lipase LipD 0.0036 0.0111 0.1556
Brugia malayi cathepsin L precursor 0.0248 0.1113 0.1099
Trypanosoma cruzi cdc2-related kinase 1 0.0258 0.1158 0.1121
Leishmania major cathepsin L-like protease 0.0597 0.2761 0.2994
Toxoplasma gondii cathepsin B 0.1943 0.9122 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0111 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2761 0.2994
Trypanosoma brucei mitotic cyclin 0.0047 0.0161 0.0131
Brugia malayi Cathepsin L-like precursor 0.0597 0.2761 0.2749
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0022 0.0006
Schistosoma mansoni cpg binding protein 0.0056 0.0206 0.02
Onchocerca volvulus Cathepsin F homolog 0.0597 0.2761 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0101 0.0416 0.1151
Loa Loa (eye worm) CYP4Cod1 0.0075 0.0295 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.1113 0.122
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2761 0.3026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0097
Brugia malayi nuclear receptor NHR-88 0.0037 0.0113 0.0097
Plasmodium vivax protein kinase Crk2 0.0258 0.1158 0.3952
Echinococcus granulosus cathepsin l cysteine peptidase 0.0597 0.2761 0.2756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.1113 0.122
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0111 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Mycobacterium ulcerans beta-lactamase 0.0036 0.0111 0.1556
Echinococcus multilocularis cyclin A3 4 0.0047 0.0161 0.0155
Brugia malayi Cyclin, N-terminal domain containing protein 0.0047 0.0161 0.0145
Leishmania major cathepsin L-like protease 0.0597 0.2761 0.2994
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0016 0.001
Loa Loa (eye worm) cysteine protease 0.0597 0.2761 0.2749
Giardia lamblia Cathepsin B precursor 0.1943 0.9122 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0304 0.1375 0.137
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0258 0.1158 0.1144
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0016 0.001
Trichomonas vaginalis cyclin A, putative 0.0342 0.1556 0.1706
Brugia malayi hypothetical protein 0.0101 0.0416 0.04
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Plasmodium falciparum cysteine proteinase falcipain 1 0.039 0.1781 0.6232
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0111 0.0121
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0248 0.1113 0.3784
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2129 1 1
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0047 0.0161 0.0155
Echinococcus multilocularis Cyclin L1 0.0047 0.0161 0.0155
Echinococcus granulosus cyclin G2 0.0047 0.0161 0.0155
Echinococcus multilocularis cyclins 0.0194 0.0857 0.0852
Entamoeba histolytica cell division protein kinase 2, putative 0.0258 0.1158 0.3835
Schistosoma mansoni hypothetical protein 0.0047 0.0161 0.0155
Brugia malayi Papain family cysteine protease containing protein 0.0597 0.2761 0.2749
Giardia lamblia Cysteine protease 0.0248 0.1113 0.1063
Brugia malayi Papain family cysteine protease containing protein 0.0248 0.1113 0.1099
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.182 0.1816
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2761 0.2994
Schistosoma mansoni cyclin l 0.0047 0.0161 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0113 0.0097
Entamoeba histolytica cysteine protease, putative 0.039 0.1781 0.6232
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0113 0.0107
Trypanosoma brucei cyclin 9 0.0047 0.0161 0.0131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0006
Brugia malayi Cathepsin L-like precursor 0.0597 0.2761 0.2749
Schistosoma mansoni smad 0.0016 0.0016 0.001
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.039 0.1781 0.1776
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0113 0.0107
Giardia lamblia Cysteine protease 0.0248 0.1113 0.1063
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0696 0.3229 0.3218
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0161 0.0177
Trichomonas vaginalis CMGC family protein kinase 0.0258 0.1158 0.1269
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0022 0.0006

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 6.474 Transactivation of human ERalpha expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay ChEMBL. 20408532
EC50 (binding) = 6.655 Transactivation of human ERbeta expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay ChEMBL. 20408532
Efficacy (binding) = 65.5 % Transactivation of human ERbeta expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay relative to 17-beta-estradiol ChEMBL. 20408532
Efficacy (binding) = 92.8 % Transactivation of human ERalpha expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay relative to 17-beta-estradiol ChEMBL. 20408532
IC50 (binding) = 6.596 Binding affinity to ERbeta by fluorescence polarization-based competitive binding assay ChEMBL. 20408532
IC50 (binding) = 6.614 Binding affinity to ERalpha by fluorescence polarization-based competitive binding assay ChEMBL. 20408532

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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