Detailed information for compound 1133699

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.346 | Formula: C12H18N2O7S
  • H donors: 6 H acceptors: 6 LogP: -1.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@@H](Nc2ccc(cc2)S(=O)(=O)N)[C@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C12H18N2O7S/c13-22(19,20)7-3-1-6(2-4-7)14-12-11(18)10(17)9(16)8(5-15)21-12/h1-4,8-12,14-18H,5H2,(H2,13,19,20)/t8-,9-,10+,11+,12-/m1/s1
  • InChiKey: RMCYKIOWPVOBJX-LDMBFOFVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0137 0.1232
Brugia malayi Nuclear hormone receptor E75 0.006 0.0163 0.0238
Echinococcus granulosus tar DNA binding protein 0.0125 0.0426 0.1081
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0426 0.1123
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0137 0.0349
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Schistosoma mansoni hypothetical protein 0.0107 0.035 0.0924
Brugia malayi MAP kinase sur-1 0.0053 0.0137 0.02
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.016 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0323 0.1217 0.3212
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0049 0.0071
Schistosoma mansoni hypothetical protein 0.0049 0.0121 0.032
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0487 0.4373
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0058 0.0058
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.0517 0.1393
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0109 0.0159
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0137 0.8603
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0154 0.0154
Mycobacterium ulcerans lipase LipD 0.0148 0.0517 0.4252
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0137 0.02
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0192 0.028
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0069 0.0615
Toxoplasma gondii hypothetical protein 0.0048 0.0116 0.0792
Brugia malayi Blistered cuticle protein 3 0.0052 0.0132 0.0192
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0021 0.019
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.016 0.1619
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0121 0.0176
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0207 0.0751 0.0751
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0137 0.1232
Echinococcus multilocularis microtubule associated protein 2 0.0965 0.3785 0.3785
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.016 0.1311
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Toxoplasma gondii ABC1 family protein 0.0148 0.0517 0.415
Brugia malayi TAR-binding protein 0.0125 0.0426 0.062
Mycobacterium ulcerans hypothetical protein 0.0148 0.0517 0.4252
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.035 0.051
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0058 0.0152
Mycobacterium tuberculosis Conserved protein 0.0148 0.0517 0.1393
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Mycobacterium ulcerans aldehyde dehydrogenase 0.0323 0.1217 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0184 0.0659 1
Schistosoma mansoni peroxidasin 0.0052 0.0132 0.0348
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.0517 0.0753
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0154 0.0407
Echinococcus granulosus nuclear receptor nhr 48 0.006 0.0163 0.0415
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0551 0.1483
Onchocerca volvulus Peroxidase homolog 0.0052 0.0132 0.0109
Onchocerca volvulus Protein ultraspiracle homolog 0.0207 0.0751 0.1018
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.0434 0.3894
Brugia malayi RNA binding protein 0.0125 0.0426 0.062
Loa Loa (eye worm) hypothetical protein 0.1737 0.687 1
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0127 0.0434 0.3894
Mycobacterium ulcerans aldehyde dehydrogenase 0.0323 0.1217 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.016 0.0917
Schistosoma mansoni coup transcription factor 0.0207 0.0751 0.1983
Echinococcus multilocularis neuropeptide s receptor 0.0498 0.1917 0.1917
Leishmania major carbonic anhydrase-like protein 0.0181 0.0647 0.5316
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0966 0.3788 0.3788
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.006 0.0163 0.0238
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0154 0.0392
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0184 0.1652
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0132 0.0192
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.0935 0.1361
Schistosoma mansoni hypothetical protein 0.015 0.0525 0.1387
Brugia malayi Thioredoxin reductase 0.0046 0.0109 0.0159
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0132 0.0192
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0058 0.0152
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0137 0.0349
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0623 0.6322
Loa Loa (eye worm) Poly(ADP-ribose) glycohydrolase 0.0173 0.0614 0.0894
Entamoeba histolytica hypothetical protein 0.015 0.0525 0.8557
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0207 0.0751 0.1094
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0069 0.0615
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0147 0.0512 0.1351
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0207 0.0751 0.1094
Onchocerca volvulus 0.0052 0.0132 0.0109
Onchocerca volvulus 0.0207 0.0751 0.1018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0032 0.0047
Loa Loa (eye worm) hypothetical protein 0.0081 0.0247 0.036
Schistosoma mansoni RAR-like nuclear receptor 0.0207 0.0751 0.1983
Echinococcus granulosus tumor protein p63 0.1003 0.3936 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0207 0.0751 0.1983
Onchocerca volvulus Bile acid receptor homolog 0.1737 0.687 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0323 0.1217 1
Brugia malayi glutathione reductase 0.0046 0.0109 0.0159
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.016 1
Echinococcus granulosus mitogen activated protein kinase 11 0.0127 0.0434 0.1102
Schistosoma mansoni ap endonuclease 0.0059 0.016 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0207 0.0751 0.1094
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.016 0.1311
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0147 0.0512 0.0512
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0132 0.0192
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0058 0.0152
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.0547 0.0797
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0193 0.0696 0.1013
Echinococcus granulosus lamin 0.0058 0.0157 0.04
Mycobacterium ulcerans hypothetical protein 0.0157 0.0551 0.4527
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0132 0.0192
Brugia malayi nuclear hormone receptor family member nhr-6 0.006 0.0163 0.0238
Echinococcus multilocularis tar DNA binding protein 0.0125 0.0426 0.0426
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0154 0.0407
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1109 0.2926
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0069 0.0396
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0184 0.1652
Brugia malayi Nuclear hormone receptor-like 1 0.0147 0.0512 0.0745
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0089 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0146
Schistosoma mansoni survival motor neuron protein 0.0049 0.0119 0.0313
Echinococcus multilocularis poly(ADP ribose) glycohydrolase 0.0173 0.0614 0.0614
Schistosoma mansoni aldehyde dehydrogenase 0.0323 0.1217 0.3212
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0053 0.0134
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0163 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0207 0.0751 0.1094
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0346 0.0932
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.0256 0.0256
Onchocerca volvulus 0.0065 0.0185 0.0187
Brugia malayi tailless protein 0.006 0.0163 0.0238
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0049 0.0071
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0192 0.0192
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.01 0.0146
Onchocerca volvulus Huntingtin homolog 0.039 0.1486 0.2096
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0091 0.0819
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0207 0.0751 0.1094
Brugia malayi hypothetical protein 0.0065 0.0185 0.0269
Plasmodium falciparum carbonic anhydrase 0.0067 0.0192 0.1514
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0132 0.0109
Toxoplasma gondii thioredoxin reductase 0.0046 0.0109 0.0735
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0157 0.0229
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0192 0.028
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0181 0.0647 0.0942
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0121 0.0308
Brugia malayi hypothetical protein 0.039 0.1486 0.2163
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0091 0.0819
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0948 0.3715 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0163 0.0163
Echinococcus multilocularis musashi 0.0058 0.0157 0.0157
Plasmodium vivax glutathione reductase, putative 0.0046 0.0109 0.0853
Onchocerca volvulus 0.0058 0.0157 0.0146
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0109 0.0853
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0184 0.0659 1
Echinococcus granulosus carbonic anhydrase 0.0067 0.0192 0.0489
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.006 0.0163 0.0163
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.016 0.1432
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.0434 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0207 0.0751 0.1094
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0207 0.0751 0.1094
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0067 0.0192 0.028
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0127 0.0434 0.0632
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0137 0.1128
Echinococcus granulosus GPCR family 2 0.0049 0.0121 0.0308
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.0517 0.4252
Loa Loa (eye worm) glutathione reductase 0.0046 0.0109 0.0159
Loa Loa (eye worm) nuclear hormone receptor 0.006 0.0163 0.0238
Brugia malayi nuclear hormone receptor 0.006 0.0163 0.0238
Brugia malayi ecdysone receptor 0.006 0.0163 0.0238
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.0517 0.1393
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.0256 0.0651
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.0517 0.0517
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Brugia malayi hypothetical protein 0.0147 0.0512 0.0745
Echinococcus granulosus FTZ F1 alpha 0.0207 0.0751 0.1909
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.0517 0.1393
Onchocerca volvulus 0.006 0.0163 0.0155
Loa Loa (eye worm) hypothetical protein 0.039 0.1486 0.2163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0058 0.0152
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0207 0.0751 0.1909
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.0434 0.3894
Schistosoma mansoni cellular tumor antigen P53 0.0147 0.0511 0.1349
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0184 0.0268
Echinococcus multilocularis ecdysone induced protein 78C 0.0207 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0067 0.0192 0.028
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0207 0.0751 0.1094
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0181 0.0647 0.1707
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0207 0.0751 0.1094
Loa Loa (eye worm) RNA binding protein 0.0125 0.0426 0.062
Echinococcus multilocularis lamin dm0 0.0058 0.0157 0.0157
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.0517 0.1393
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1109 0.2926
Loa Loa (eye worm) hypothetical protein 0.0571 0.2209 0.3215
Loa Loa (eye worm) hypothetical protein 0.0103 0.0336 0.0489
Brugia malayi hypothetical protein 0.0458 0.1756 0.2556
Loa Loa (eye worm) hypothetical protein 0.0147 0.0511 0.0744
Schistosoma mansoni jun-related protein 0.0068 0.0194 0.0512
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0127 0.0434 0.3565
Mycobacterium tuberculosis Probable reductase 0.0106 0.0346 0.0932
Loa Loa (eye worm) hypothetical protein 0.0239 0.0879 0.1279
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0163 0.0155
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.01 0.0901
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.0547 0.0797
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0207 0.0751 0.1909
Loa Loa (eye worm) hypothetical protein 0.0081 0.0247 0.036
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0137 0.0971
Onchocerca volvulus 0.0052 0.0132 0.0109
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Echinococcus multilocularis neuropeptide receptor A26 0.0498 0.1917 0.1917
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0346 0.0932
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0147 0.0512 0.1351
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.006 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0057 0.0153 0.0223
Loa Loa (eye worm) hypothetical protein 0.0033 0.0058 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0517 0.5249
Schistosoma mansoni ap endonuclease 0.0059 0.016 0.0421
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0388 0.0565
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0207 0.0751 0.1094
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0207 0.0751 0.1094
Echinococcus multilocularis muscleblind protein 1 0.0103 0.0336 0.0336
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0192 0.0508
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0181 0.0647 0.1707
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0132 0.0109
Onchocerca volvulus 0.0148 0.0517 0.0675
Mycobacterium leprae conserved hypothetical protein 0.0148 0.0517 0.7656
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0184 0.1652
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0184 0.0659 0.1775
Schistosoma mansoni hypothetical protein 0.0049 0.0121 0.032
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.0879 0.0879
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0426 0.1123
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0157 0.0229
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0157 0.0229
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0696 0.1837
Trypanosoma brucei protein kinase, putative 0.0053 0.0137 0.1232
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0154 0.0392
Echinococcus granulosus geminin 0.0367 0.1391 0.3533
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0323 0.1217 0.3275
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0069 0.0695
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.016 0.1692
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.016 0.016
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.0517 0.1314
Brugia malayi Nuclear hormone receptor-like 1 0.0147 0.0512 0.0745
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Brugia malayi beta-lactamase family protein 0.0148 0.0517 0.0753
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0614 0.5512
Loa Loa (eye worm) blistered cuticle protein 3 0.0052 0.0132 0.0192
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0069 0.0695
Brugia malayi Muscleblind-like protein 0.0103 0.0336 0.0489
Echinococcus multilocularis muscleblind protein 0.0103 0.0336 0.0336
Echinococcus granulosus carbonic anhydrase II 0.0181 0.0647 0.1643
Schistosoma mansoni hypothetical protein 0.0067 0.0192 0.0508
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.0517 0.4252
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0517 0.5249
Brugia malayi beta-lactamase family protein 0.0148 0.0517 0.0753
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0121 0.0121
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0091 0.0819
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0147 0.0512 0.13
Loa Loa (eye worm) hypothetical protein 0.039 0.1486 0.2163
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0207 0.0751 0.1909
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0393 0.1059
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Schistosoma mansoni nuclear receptor 0.006 0.0163 0.0432
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0069 0.0174
Schistosoma mansoni nuclear receptor nhr-48 0.006 0.0163 0.0432
Trichomonas vaginalis set domain proteins, putative 0.0265 0.0986 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0207 0.0751 0.1094
Brugia malayi beta-lactamase 0.0148 0.0517 0.0753
Brugia malayi nuclear receptor RXR 0.0147 0.0512 0.0745
Leishmania major DNA polymerase eta, putative 0.0044 0.01 0.0825
Schistosoma mansoni hypothetical protein 0.0068 0.0194 0.0512
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0207 0.0751 0.1909
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0323 0.1217 1
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0069 0.0069
Trichomonas vaginalis hypothetical protein 0.0184 0.0659 0.6691
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Onchocerca volvulus 0.006 0.0163 0.0155
Brugia malayi jmjC domain containing protein 0.0058 0.0154 0.0224
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0069 0.0563
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0163 0.0415
Leishmania major hypothetical protein, conserved 0.0148 0.0517 0.4252
Schistosoma mansoni lamin 0.0058 0.0157 0.0415
Brugia malayi jmjC domain containing protein 0.0058 0.0154 0.0224
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0184 0.2998
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Brugia malayi steroid hormone receptor 0.0207 0.0751 0.1094
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0207 0.0751 0.1094
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Brugia malayi ecdysteroid receptor 0.1737 0.687 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0032 0.0047
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0069 0.0563
Onchocerca volvulus Dual oxidase homolog 0.0052 0.0132 0.0109
Echinococcus multilocularis geminin 0.0367 0.1391 0.1391
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.0517 0.1393
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.0426 0.062
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0021 0.0021
Onchocerca volvulus 0.0058 0.0157 0.0146
Brugia malayi Poly 0.0173 0.0614 0.0894
Echinococcus granulosus neuropeptide receptor A26 0.0498 0.1917 0.4869
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0163 0.0163
Loa Loa (eye worm) nuclear receptor nhr-7B 0.006 0.0163 0.0238
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0049 0.0121 0.0176
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0154 0.0407
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0192 0.0192
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0207 0.0751 0.0751
Brugia malayi small heat shock protein 0.0571 0.2209 0.3215
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.016 0.0232
Onchocerca volvulus 0.0148 0.0517 0.0675
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0517 0.1366
Brugia malayi nuclear receptor NHR-67 0.006 0.0163 0.0238
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0184 0.0659 0.5338
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0192 0.0508
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0696 0.1837
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0487 0.4004
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0021 0.0056
Echinococcus multilocularis lamin 0.0058 0.0157 0.0157
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0137 0.1232
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0517 0.4643
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0137 0.0362
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0184 0.0486
Entamoeba histolytica hypothetical protein 0.015 0.0525 0.8557
Brugia malayi hypothetical protein 0.015 0.0525 0.0765
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0156 0.0547 0.0797
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0614 1
Echinococcus granulosus intermediate filament protein 0.0058 0.0157 0.04
Schistosoma mansoni hypothetical protein 0.0049 0.0121 0.032
Onchocerca volvulus Chorion peroxidase homolog 0.0052 0.0132 0.0109
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Leishmania major DNA polymerase eta, putative 0.0031 0.0048 0.0394
Onchocerca volvulus Peroxidase homolog 0.0052 0.0132 0.0109
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0393 0.1059
Loa Loa (eye worm) hypothetical protein 0.0458 0.1756 0.2556
Loa Loa (eye worm) hypothetical protein 0.0103 0.0336 0.0489
Brugia malayi nuclear hormone receptor 0.0207 0.0751 0.1094
Loa Loa (eye worm) DR-78 0.006 0.0163 0.0238
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0517 0.5249
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0075 0.0189
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.016 0.1432
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0393 0.1059
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0192 0.0192
Echinococcus granulosus polyADP ribose glycohydrolase 0.0173 0.0614 0.156
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0393 0.5609
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.0517 0.1393
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0075 0.0075
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0037 0.0093
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0058 0.0306
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0137 0.1392
Echinococcus granulosus peroxidasin 0.0052 0.0132 0.0335
Loa Loa (eye worm) carbonic anhydrase 3 0.0181 0.0647 0.0942
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.0879 0.2232
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0109 0.0277
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0137 0.1232
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.0696 0.1768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0696 0.1837
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0181 0.0647 0.0942
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0487 0.4373
Schistosoma mansoni hypothetical protein 0.0367 0.1391 0.3671
Entamoeba histolytica hypothetical protein 0.0173 0.0614 1
Echinococcus multilocularis dna polymerase eta 0.0044 0.01 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Brugia malayi map kinase activated protein kinase protein 2 0.0966 0.3788 0.5515
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0207 0.0751 0.1018
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1114 1
Brugia malayi Peroxidasin 0.0052 0.0132 0.0192
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0388 0.0565
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0192 0.028
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0426 0.1123
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Schistosoma mansoni inositol monophosphatase 0.0036 0.0069 0.0181
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.0525 0.0525
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0163 0.0163
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0069 0.0615
Echinococcus multilocularis GPCR, family 2 0.0049 0.0121 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.0696 0.0696
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.016 0.0405
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0229
Brugia malayi nuclear hormone receptor family member odr-7 0.006 0.0163 0.0238
Plasmodium falciparum enoyl-acyl carrier reductase 0.0184 0.0659 1
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0132 0.0192
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0132 0.0192
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0207 0.0751 0.1909
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0207 0.0751 0.1094
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Echinococcus multilocularis jun protein 0.0083 0.0256 0.0256
Loa Loa (eye worm) beta-lactamase 0.0148 0.0517 0.0753
Brugia malayi conserved hypotetical protein 0.006 0.0163 0.0238
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0517 0.4643
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0207 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0147 0.0512 0.0745
Echinococcus multilocularis thyroid hormone receptor alpha 0.0296 0.1109 0.1109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.0696 0.0696
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0053 0.0144
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0058 0.0147
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0058 0.0058
Trypanosoma brucei carbonic anhydrase-like protein 0.0181 0.0647 0.5805
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.016 0.2598
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0181 0.0647 0.5805
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0323 0.1217 0.3091
Brugia malayi hypothetical protein 0.0239 0.0879 0.1279
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0119 0.0173
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0192 0.028
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0137 0.1392
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0132 0.0192
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0132 0.0192
Echinococcus granulosus carbonic anhydrase 0.0067 0.0192 0.0489
Brugia malayi Steroid receptor seven-up type 2 0.0207 0.0751 0.1094
Brugia malayi hypothetical protein 0.006 0.0163 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0021 0.0215
Echinococcus granulosus jun protein 0.0083 0.0256 0.0651
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0207 0.0751 0.1983
Trypanosoma brucei trypanothione reductase 0.0046 0.0109 0.0979
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.1114 0.9156
Onchocerca volvulus 0.0052 0.0132 0.0109
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0207 0.0751 0.0751
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0184 0.0268
Echinococcus multilocularis carbonic anhydrase II 0.0181 0.0647 0.0647
Echinococcus multilocularis FTZ F1 alpha 0.0207 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0147 0.0512 0.0745
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Echinococcus granulosus neuropeptide s receptor 0.0498 0.1917 0.4869
Brugia malayi intermediate filament protein 0.0058 0.0157 0.0229
Entamoeba histolytica hypothetical protein 0.0024 0.0021 0.0345
Schistosoma mansoni nuclear hormone receptor 0.0207 0.0751 0.1983
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0346 0.4832
Loa Loa (eye worm) hypothetical protein 0.0067 0.0192 0.028
Mycobacterium ulcerans beta-lactamase 0.0148 0.0517 0.4252
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0207 0.0751 0.1094
Schistosoma mansoni hypothetical protein 0.0367 0.1391 0.3671
Brugia malayi Nuclear hormone receptor E75 0.006 0.0163 0.0238
Echinococcus granulosus microtubule associated protein 2 0.0965 0.3785 0.9615
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.0696 0.1768
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.0525 0.1335
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0207 0.0751 0.1094
Onchocerca volvulus Huntingtin homolog 0.039 0.1486 0.2096
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.01 0.0901
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0137 0.0137
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0121 0.0176
Loa Loa (eye worm) hypothetical protein 0.0067 0.0192 0.028
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0091 0.0819
Loa Loa (eye worm) hypothetical protein 0.0147 0.0512 0.0745
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0163 0.0155
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0184 0.1513
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0346 0.0932
Onchocerca volvulus 0.0147 0.0511 0.0666
Schistosoma mansoni steroid hormone receptor ad4bp 0.0207 0.0751 0.1983
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0426 0.1123
Brugia malayi Nuclear hormone receptor-like 1 0.0207 0.0751 0.1094
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0053
Echinococcus multilocularis peroxidasin 0.0052 0.0132 0.0132
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.0935 0.1361
Schistosoma mansoni hypothetical protein 0.0049 0.0119 0.0313
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0109 0.0979
Schistosoma mansoni nuclear hormone receptor 0.006 0.0163 0.0432
Brugia malayi orphan nuclear receptor NR2E1 0.006 0.0163 0.0238
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0614 0.5512
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0192 0.028
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0966 0.3788 0.9624
Schistosoma mansoni transcription factor LCR-F1 0.015 0.0525 0.1387
Schistosoma mansoni lamin 0.0058 0.0157 0.0415
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0048 0.043
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0181 0.0647 0.0942
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.0547 0.0797
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Loa Loa (eye worm) steroid hormone receptor 0.0207 0.0751 0.1094
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.1114 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0037 0.0037
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0048 0.0224
Entamoeba histolytica hypothetical protein 0.015 0.0525 0.8557
Schistosoma mansoni carbonic anhydrase 0.0067 0.0192 0.0508
Loa Loa (eye worm) hypothetical protein 0.0147 0.0512 0.0745
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0323 0.1217 0.1217
Brugia malayi Pre-SET motif family protein 0.0233 0.0857 0.1247
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0247 0.4027
Loa Loa (eye worm) TAR-binding protein 0.0125 0.0426 0.062
Schistosoma mansoni poly(ADP-ribose) glycohydrolase 0.0173 0.0614 0.1621
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0121 0.0176
Toxoplasma gondii hypothetical protein 0.0067 0.0192 0.1432
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0184 0.0659 0.5419
Loa Loa (eye worm) hypothetical protein 0.0107 0.035 0.051
Loa Loa (eye worm) nuclear receptor NHR-67 0.006 0.0163 0.0238
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Mycobacterium tuberculosis Conserved protein 0.0148 0.0517 0.1393
Schistosoma mansoni DNA polymerase eta 0.0044 0.01 0.0265
Loa Loa (eye worm) inositol-1 0.0036 0.0069 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0623 0.6322
Onchocerca volvulus 0.0458 0.1756 0.2493
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0966 0.3788 0.5515
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.006 0.0163 0.0432
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0109 0.0294
Echinococcus granulosus thyroid hormone receptor alpha 0.006 0.0163 0.0415
Brugia malayi Inositol-1 0.0036 0.0069 0.01
Echinococcus multilocularis tumor protein p63 0.1003 0.3936 0.3936
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.0517 0.1393
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0207 0.0751 0.1983
Onchocerca volvulus 0.0049 0.0119 0.0089
Onchocerca volvulus 0.0148 0.0517 0.0675
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.016 0.154
Brugia malayi photoreceptor-specific nuclear receptor 0.0207 0.0751 0.1094
Schistosoma mansoni peroxidasin 0.0052 0.0132 0.0348
Mycobacterium tuberculosis Conserved protein 0.0148 0.0517 0.1393
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0193 0.0696 0.1013
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0089 0.0281 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0207 0.0751 0.1094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0011
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0184 0.0468
Brugia malayi nuclear receptor NHR-88 0.006 0.0163 0.0238
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0077 0.0231 0.3768
Schistosoma mansoni nuclear receptor 0.006 0.0163 0.0432
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0207 0.0751 0.1909
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0517 0.1366
Schistosoma mansoni nuclear hormone receptor 0.006 0.0163 0.0432
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0517 0.5249
Brugia malayi nuclear receptor RXR 0.006 0.0163 0.0238
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0077 0.0231 0.1758
Schistosoma mansoni intermediate filament proteins 0.0058 0.0157 0.0415
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.0426 0.062
Schistosoma mansoni retinoic acid receptor RXR 0.0207 0.0751 0.1983
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0207 0.0751 0.1094
Schistosoma mansoni inositol monophosphatase 0.0036 0.0069 0.0181
Toxoplasma gondii exonuclease III APE 0.0059 0.016 0.1157
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0346 0.0932
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0207 0.0751 0.1909
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0207 0.0751 0.1983
Brugia malayi hypothetical protein 0.0147 0.0512 0.0745
Schistosoma mansoni hypothetical protein 0.0049 0.0121 0.032
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0137 0.1392
Schistosoma mansoni serine/threonine protein kinase 0.0966 0.3788 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.0857 0.1247
Brugia malayi bZIP transcription factor family protein 0.0083 0.0256 0.0373
Schistosoma mansoni hypothetical protein 0.0089 0.0281 0.0742
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.016 0.0429
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0021 0.019
Loa Loa (eye worm) hypothetical protein 0.0147 0.0512 0.0745
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0109 0.0109
Entamoeba histolytica hypothetical protein 0.0077 0.0231 0.3768
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0147 0.0512 0.0745
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0587 0.0777
Schistosoma mansoni microtubule-associated protein tau 0.0965 0.3785 0.9991
Echinococcus granulosus carbonic anhydrase 0.0067 0.0192 0.0489
Trypanosoma brucei poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0614 0.5512
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0346 0.0932
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.0517 0.4643
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Brugia malayi nuclear receptor NHR-88 0.0207 0.0751 0.1094
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0207 0.0751 0.1983
Echinococcus granulosus ecdysone induced protein 78C 0.0207 0.0751 0.1909
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.006 0.0163 0.0415
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.016 0.0232
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0207 0.0751 0.0751
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0207 0.0751 0.1983
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0207 0.0751 0.0751
Echinococcus granulosus lamin dm0 0.0058 0.0157 0.04
Toxoplasma gondii aldehyde dehydrogenase 0.0323 0.1217 1
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0173 0.0614 0.4959
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0154 0.0224
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.016 0.1432
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0207 0.0751 0.1094
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0069 0.0695
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0184 0.0659 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0008 0.0068
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.0434 0.0434
Echinococcus granulosus dna polymerase eta 0.0044 0.01 0.0255
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0137 0.1128
Echinococcus granulosus muscleblind protein 0.0103 0.0336 0.0853
Brugia malayi Pre-SET motif family protein 0.0033 0.0058 0.0084
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0181 0.0647 0.5805
Brugia malayi MH2 domain containing protein 0.0116 0.0388 0.0565
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.016 0.1619
Plasmodium vivax hypothetical protein, conserved 0.0148 0.0517 0.7639
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0069 0.1116
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0184 0.0659 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Onchocerca volvulus 0.0265 0.0986 0.1362
Leishmania major trypanothione reductase 0.0046 0.0109 0.0896
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0207 0.0751 0.1094
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0128 0.1148
Echinococcus granulosus mitogen activated protein kinase 14 0.0127 0.0434 0.1102
Schistosoma mansoni zinc finger protein 0.006 0.0163 0.0432
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0121 0.0308
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0137 0.0137
Echinococcus multilocularis nuclear receptor nhr 48 0.006 0.0163 0.0163
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0517 0.5249
Brugia malayi hypothetical protein 0.0052 0.0132 0.0192
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.006 0.0163 0.0432
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0137 0.1232
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0163 0.0415
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.0434 0.0434
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0426 0.1123
Brugia malayi P38 map kinase family protein 2 0.0127 0.0434 0.0632
Entamoeba histolytica hypothetical protein 0.015 0.0525 0.8557
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0247 0.4027
Trichomonas vaginalis esterase, putative 0.0148 0.0517 0.5249
Mycobacterium leprae Probable lipase LipE 0.0148 0.0517 0.7656
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0192 0.0508
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1114 1
Brugia malayi hypothetical protein 0.006 0.0163 0.0238
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0132 0.0192
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.0517 0.0753
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0137 0.1392
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.0434 0.0434

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 18 nM Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow carbon dioxide hydrase assay method ChEMBL. 20211561
Ki (binding) = 930 nM Inhibition of human recombinant carbonic anhydrase1 after 15 mins by stopped flow carbon dioxide hydrase assay method ChEMBL. 20211561

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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