Detailed information for compound 1143485

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.391 | Formula: C13H14N2O4S2
  • H donors: 2 H acceptors: 5 LogP: 1.51 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]([C@H]1C(=O)N2[C@@H]1[C@@H](C)C(=C2C(=O)O)Sc1nccs1)O
  • InChi: 1S/C13H14N2O4S2/c1-5-8-7(6(2)16)11(17)15(8)9(12(18)19)10(5)21-13-14-3-4-20-13/h3-8,16H,1-2H3,(H,18,19)/t5-,6-,7-,8-/m1/s1
  • InChiKey: ICYYFEDXLOJVIO-WCTZXXKLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0047 0.0089 0.0845
Brugia malayi Muscleblind-like protein 0.0145 0.0777 0.0917
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0047 0.0088 0.5
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1236 0.8464 0.8464
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0135 0.0127
Loa Loa (eye worm) MBCTL1 0.0054 0.0135 0.0142
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0071 0.0084
Leishmania major phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.0921
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0186 0.1068 0.1067
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.028 0.1727 0.7888
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0334 0.211 0.3544
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0071 0.0071
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0334 0.211 0.3544
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0001
Leishmania major hypothetical protein, unknown function 0.0113 0.0554 0.0921
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0877 0.5939 1
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0071 0.0661
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0071 0.0064
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0816 0.5506 0.927
Brugia malayi hypothetical protein 0.0172 0.0968 0.1144
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0047 0.0088 0.0104
Echinococcus granulosus thioredoxin glutathione reductase 0.0137 0.0719 0.0718
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0877 0.5939 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0186 0.1068 0.1061
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0113 0.0554 0.1114
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0047 0.0088 0.008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0554 0.2506
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0071 0.0064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0561 0.3708 0.4381
Loa Loa (eye worm) phosphatidylinositol 3 0.0221 0.1312 0.1457
Echinococcus granulosus microtubule associated protein 2 0.0771 0.519 0.519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0135
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0047 0.0088 0.0164
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0208 0.1222 0.1357
Mycobacterium tuberculosis Probable reductase 0.031 0.1943 0.888
Giardia lamblia GTOR 0.0877 0.5939 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.0054 0.0135 0.0142
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0561 0.3708 0.3707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.031 0.1943 0.888
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0088 0.0095
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.3269 0.5499
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0186 0.1068 0.1786
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0088 1
Brugia malayi beta-lactamase 0.0036 0.0008 0.0009
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0071 0.0064
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0135 0.0135
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0113 0.0554 0.0921
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0777 0.0776
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0877 0.5939 0.5938
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0071 0.0071
Toxoplasma gondii target of rapamycin (TOR), putative 0.0731 0.491 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0186 0.1068 0.1787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0645 0.4298 0.7234
Echinococcus multilocularis serine protein kinase ATM 0.0291 0.1803 0.1803
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0554 0.5153
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0071 0.0084
Mycobacterium tuberculosis Probable dehydrogenase 0.031 0.1943 0.888
Schistosoma mansoni coup transcription factor 0.0045 0.0071 0.0064
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0113 0.0554 0.0553
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1454 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0008 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.1803 0.2131
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0113 0.0554 0.0553
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Brugia malayi nuclear receptor NHR-88 0.0045 0.0071 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.3269 0.5499
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0113 0.0554 0.0646
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0554 0.061
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0638 0.425 0.5022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0877 0.5939 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.031 0.1943 0.888
Onchocerca volvulus 0.008 0.0322 0.327
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0089 0.0081
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0088 0.0135
Brugia malayi Cytochrome P450 family protein 0.0084 0.0347 0.041
Brugia malayi beta-lactamase family protein 0.0036 0.0008 0.0009
Toxoplasma gondii thioredoxin reductase 0.0136 0.0715 0.1442
Echinococcus granulosus histone acetyltransferase KAT2B 0.0053 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0208 0.1222 0.1215
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0071 0.0064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0071 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0113 0.0554 0.0654
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0071 0.0661
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0071 0.0064
Echinococcus multilocularis muscleblind protein 0.0145 0.0777 0.0776
Loa Loa (eye worm) hypothetical protein 0.0177 0.1005 0.1115
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0413 0.2666 0.4481
Brugia malayi mbt repeat family protein 0.0047 0.0089 0.0105
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0823 0.0823
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0291 0.1803 0.3027
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0113 0.0554 0.0553
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0823 0.0816
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0053 0.0126 0.0241
Brugia malayi Inositol-1 0.0036 0.0008 0.001
Toxoplasma gondii NADPH-glutathione reductase 0.0047 0.0088 0.0164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0071 0.0071
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0186 0.1068 0.1787
Loa Loa (eye worm) hypothetical protein 0.0068 0.0237 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4088 0.6879
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.1005 0.1682
Treponema pallidum fructose-bisphosphate aldolase 0.0573 0.3791 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0186 0.1068 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0071 0.0071
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1236 0.8464 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0113 0.0554 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.1222 0.2047
Brugia malayi ecdysteroid receptor 0.0045 0.0071 0.0084
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0448 0.2912 0.4896
Loa Loa (eye worm) hypothetical protein 0.0113 0.0554 0.061
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0089 0.0081
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0047 0.0088 0.0135
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1236 0.8464 1
Loa Loa (eye worm) hypothetical protein 0.0291 0.1803 0.2006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0071 0.0084
Loa Loa (eye worm) phosphatidylinositol 3 0.0656 0.4378 0.4882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.1803 0.3027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0071 0.0084
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0877 0.5939 1
Plasmodium vivax glutathione reductase, putative 0.0136 0.0715 0.6671
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0186 0.1068 0.1253
Brugia malayi mbt repeat family protein 0.0047 0.0089 0.0105
Toxoplasma gondii FATC domain-containing protein 0.0291 0.1803 0.3663
Schistosoma mansoni hypothetical protein 0.0287 0.1781 0.1774
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0071 0.0071
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.028 0.1727 1
Echinococcus granulosus geminin 0.0358 0.2281 0.2281
Brugia malayi FAT domain containing protein 0.0208 0.1222 0.1444
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0053 0.0126 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0071 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0583 0.3868 0.6508
Schistosoma mansoni bromodomain containing protein 0.0065 0.0216 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.2912 0.4896
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0761 0.512 0.862
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0816 0.5506 0.6501
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0071 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0088 0.0095
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0291 0.1803 0.2123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0553 0.3651 0.6143
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0877 0.5939 0.7016
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0047 0.0088 0.0135
Loa Loa (eye worm) hypothetical protein 0.0172 0.0968 0.1073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4091 0.6885
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0554 0.061
Trichomonas vaginalis mercuric reductase, putative 0.0047 0.0088 0.0135
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0761 0.512 0.862
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0071 0.0071
Leishmania major phosphatidylinositol kinase related protein, putative 0.0113 0.0554 0.0921
Loa Loa (eye worm) inositol-1 0.0036 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.0145 0.0777 0.0859
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0047 0.0088 0.0758
Leishmania major phosphatidylinositol kinase, putative 0.0113 0.0554 0.0921
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0438 0.2842 0.4778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4091 0.6885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.3269 0.5499
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0823 0.0823
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0113 0.0554 0.4796
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0345 0.2187 1
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0089 0.0091
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0071 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0071 0.0071
Onchocerca volvulus 0.0113 0.0554 0.5684
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Entamoeba histolytica hypothetical protein 0.0113 0.0554 0.092
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0089 0.0088
Trichomonas vaginalis glutathione reductase, putative 0.0047 0.0088 0.0135
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0071 0.0064
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.031 0.1943 0.888
Entamoeba histolytica hypothetical protein 0.0113 0.0554 0.092
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0071 0.0071
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0113 0.0554 0.0654
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0008 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0696 0.0769
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0113 0.0554 0.1114
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.0823 0.0911
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0334 0.211 0.3544
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0221 0.1312 0.1542
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0554 0.061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0071 0.0084
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0135 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4088 0.6879
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0071 0.0084
Loa Loa (eye worm) glutathione reductase 0.0136 0.0715 0.079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0645 0.4298 0.7234
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0113 0.0554 0.0646
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Giardia lamblia NADH oxidase lateral transfer candidate 0.0047 0.0088 0.0013
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0008 0.0003
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1236 0.8464 1
Leishmania major trypanothione reductase 0.0136 0.0715 0.1192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0669 0.4473 0.7528
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0186 0.1068 0.1253
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0053 0.0126 0.02
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0113 0.0554 0.0654
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0186 0.1068 0.1067
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0071 0.0084
Leishmania major phosphatidylinositol 3-kinase, putative 0.0499 0.3269 0.5499
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0071 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0497 0.0579
Leishmania major phosphatidylinositol 3-kinase, putative 0.0186 0.1068 0.1787
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0008 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0334 0.211 0.2493
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0071 0.0064
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.041 0.2645 0.2645
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0113 0.0554 0.0553
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0071 0.0071
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0554 0.2506
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0173 0.0976 0.0976
Brugia malayi Thioredoxin reductase 0.0136 0.0715 0.0844
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0761 0.5117 0.8614
Echinococcus granulosus expressed protein 0.0425 0.2751 0.2751
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0047 0.0088 0.0758
Brugia malayi Bromodomain containing protein 0.0077 0.0296 0.035
Brugia malayi MH2 domain containing protein 0.0133 0.0696 0.0822
Echinococcus granulosus histone acetyltransferase KAT2B 0.0166 0.0926 0.0926
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0816 0.5506 0.6505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0877 0.5939 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.031 0.1943 0.888
Trypanosoma cruzi target of rapamycin kinase 3 0.0761 0.512 0.6046
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0186 0.1068 0.1787
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0136 0.0715 0.3244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0823 0.0823
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0441 0.2865 0.4754
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0345 0.2187 1
Plasmodium vivax thioredoxin reductase, putative 0.0136 0.0715 0.6671
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0089 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0761 0.5117 0.8614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.3443 0.5793
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.028 0.1727 0.7888
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0499 0.3269 0.5499
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0071 0.0071
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0047 0.0088 0.0467
Entamoeba histolytica hypothetical protein 0.0113 0.0554 0.092
Echinococcus multilocularis geminin 0.0358 0.2281 0.2281
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0089 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4091 0.6885
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0192 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0554 0.0921
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0186 0.1068 0.1786
Brugia malayi Bromodomain containing protein 0.0041 0.0046 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.3443 0.5793
Schistosoma mansoni hypothetical protein 0.0358 0.2281 0.2275
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0186 0.1068 0.1184
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0186 0.1068 0.1261
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0589 0.3908 0.6575
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0071 0.0071
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0089 0.0088
Plasmodium falciparum glutathione reductase 0.0136 0.0715 0.6426
Loa Loa (eye worm) phosphatidylinositol 3 0.0877 0.5939 0.6627
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0047 0.0088 0.0369
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0081 0.0122
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0071 0.0071
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0177 0.1005 0.118
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.3443 0.5793
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0071 0.0084
Schistosoma mansoni microtubule-associated protein tau 0.0771 0.519 0.5186
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0816 0.5506 0.927
Onchocerca volvulus 0.0172 0.0968 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0823 0.0816
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0047 0.0088 0.0077
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0816 0.5506 0.927
Giardia lamblia Hypothetical protein 0.0113 0.0554 0.0808
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0173 0.0976 0.0969
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0186 0.1068 0.1067
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0816 0.5506 0.927
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0291 0.1803 0.2123
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0047 0.0088 0.0467
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0291 0.1803 0.1797
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0113 0.0554 0.4796
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0008 0.0008
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0186 0.1068 0.1787
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0071 0.0071
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0008 0.0009
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0877 0.5939 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1365 0.6229
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0135 0.016
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.041 0.2645 0.2645
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1005 0.1682
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0113 0.0554 0.0921
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0071 0.0071
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0113 0.0554 0.0646
Schistosoma mansoni hypothetical protein 0.0358 0.2281 0.2275
Loa Loa (eye worm) hypothetical protein 0.0157 0.0864 0.0957
Trypanosoma cruzi trypanothione reductase, putative 0.0136 0.0715 0.0836
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0071 0.0084
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0071 0.0071
Brugia malayi glutathione reductase 0.0136 0.0715 0.0844
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0877 0.5939 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0047 0.0088 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4088 0.6879
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0047 0.0088 0.0088
Brugia malayi steroid hormone receptor 0.0045 0.0071 0.0084
Loa Loa (eye worm) thioredoxin reductase 0.0136 0.0715 0.079
Mycobacterium tuberculosis Probable oxidoreductase 0.0345 0.2187 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0071 0.0071
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0589 0.3908 0.6575
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0071 0.0661
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.3269 0.5499
Plasmodium falciparum thioredoxin reductase 0.0047 0.0088 0.0077
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0089 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.1372 0.2301
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.0322 0.0321
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.0646
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0113 0.0554 0.5153
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0208 0.1222 0.1221
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0113 0.0554 0.0921
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0113 0.0554 0.092
Plasmodium falciparum thioredoxin reductase 0.0136 0.0715 0.6426
Loa Loa (eye worm) hypothetical protein 0.0047 0.0089 0.0091
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0071 0.0064
Loa Loa (eye worm) hypothetical protein 0.0044 0.0063 0.0061
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0071 0.0071
Giardia lamblia Fructose-bisphosphate aldolase 0.0573 0.3791 0.6334
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0334 0.211 0.3544
Echinococcus granulosus muscleblind protein 0.0145 0.0777 0.0776
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0334 0.211 0.3544
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Plasmodium vivax hypothetical protein 0.0113 0.0554 0.5153
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0071 0.0084
Loa Loa (eye worm) hypothetical protein 0.0561 0.3708 0.4134
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0816 0.5506 0.6501
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0053 0.0126 0.1117
Echinococcus multilocularis expressed protein 0.0425 0.2751 0.2751
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0047 0.0088 0.0467
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0291 0.1803 0.1803
Trichomonas vaginalis bromodomain-containing protein, putative 0.0053 0.0126 0.02
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0656 0.4378 0.7368
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0135 0.0135
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0192 0.0191
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.1068 0.1068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0186 0.1068 0.1787
Loa Loa (eye worm) hypothetical protein 0.0145 0.0777 0.0859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0761 0.5117 0.8614
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0877 0.5939 0.7014
Loa Loa (eye worm) hypothetical protein 0.008 0.0322 0.0351
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0186 0.1068 0.2162
Brugia malayi beta-lactamase family protein 0.0036 0.0008 0.0009
Plasmodium falciparum glutathione reductase 0.0047 0.0088 0.0077
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0113 0.0554 0.0553
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Schistosoma mansoni fkbp-rapamycin associated protein 0.0291 0.1803 0.1797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0877 0.5939 1
Brugia malayi nuclear hormone receptor 0.0045 0.0071 0.0084
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0113 0.0554 0.0546
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0113 0.0554 0.1114
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0334 0.211 0.2104
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0186 0.1068 0.1061
Loa Loa (eye worm) hypothetical protein 0.0255 0.1554 0.1727
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0088 0.0095
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Entamoeba histolytica protein kinase rad3, putative 0.0291 0.1803 0.3027
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.202 0.3393
Leishmania major hypothetical protein, conserved 0.0218 0.1295 0.2171
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1236 0.8464 0.8464
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0656 0.4378 0.7368
Onchocerca volvulus 0.0113 0.0554 0.5684
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.1068 0.1068
Giardia lamblia Phosphatidylinositol 4-kinase 0.0113 0.0554 0.0808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0761 0.5117 0.8614
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.031 0.1943 0.888
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0071 0.0071
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0291 0.1803 0.1803
Loa Loa (eye worm) acetyltransferase 0.0173 0.0976 0.1082
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0008 0.0007
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0208 0.1222 0.1221
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0823 0.0823
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.1803 0.2131
Loa Loa (eye worm) hypothetical protein 0.0116 0.0574 0.0633
Echinococcus multilocularis microtubule associated protein 2 0.0771 0.519 0.519
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0347 0.0379
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0071 0.0084
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0656 0.4378 0.7368
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0135
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.5153
Entamoeba histolytica hypothetical protein 0.0668 0.4463 0.7512
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0008 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0334 0.211 0.3544
Schistosoma mansoni hypothetical protein 0.0113 0.0554 0.0546
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0071 0.0084
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1236 0.8464 0.8463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0554 0.0921
Loa Loa (eye worm) phosphatidylinositol 3 0.1306 0.8958 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0045 0.0071 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.0921
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0071 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0071 0.0064
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0047 0.0088 0.0135
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0345 0.2187 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.0322 0.0314
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0088 0.0135
Echinococcus multilocularis 0.0113 0.0554 0.0553
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0071 0.0064
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0696 0.0769
Loa Loa (eye worm) hypothetical protein 0.0157 0.0864 0.0957
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1454 1 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.0322 0.038
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.0823 0.0972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0761 0.5117 0.8614
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0668 0.4463 0.7512
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0089 0.0845
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0321 0.202 0.4105
Onchocerca volvulus 0.0045 0.0071 0.0661
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0088 1
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0071 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0321 0.202 0.2248
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0877 0.5939 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4091 0.6885
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0261 0.1596 0.2587
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0877 0.5939 0.5938
Echinococcus granulosus serine protein kinase ATM 0.0291 0.1803 0.1803
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0554 0.061
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0334 0.211 0.2486
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0703 0.4708 0.7924
Trypanosoma brucei trypanothione reductase 0.0136 0.0715 0.1192
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0071 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0113 0.0554 0.0546
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0186 0.1068 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0561 0.3708 0.3707
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0877 0.5939 0.5935
Echinococcus multilocularis Zinc finger, PHD finger 0.0186 0.1068 0.1067
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.0646
Brugia malayi acetyltransferase, GNAT family protein 0.0173 0.0976 0.1154
Entamoeba histolytica hypothetical protein 0.0291 0.1803 0.3027
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0346 0.2194 0.3686
Echinococcus multilocularis thioredoxin glutathione reductase 0.0137 0.0719 0.0718
Loa Loa (eye worm) phosphatidylinositol kinase 0.0113 0.0554 0.061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0823 0.0816
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0186 0.1068 0.2162
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0071 0.0071
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.0322 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.1803 0.3027
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.5153
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0047 0.0088 0.0088
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0877 0.5939 0.7014
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0047 0.0088 0.0077

Activities

Activity type Activity value Assay description Source Reference
Binding (binding) = 69 % Binding affinity towards Human Serum albumin. ChEMBL. No reference
MIC (functional) = 0.78 ug ml-1 In vitro minimum inhibitory concentration of the compound against Escherichia coli NIHJ JC-2 ChEMBL. No reference
Time (binding) = 15 min Time of enzyme-catalyzed hydrolysis from 500 uM to 400 uM in the presence of purified renal DHP-1 of swine ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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