Detailed information for compound 114485

Basic information

Technical information
  • TDR Targets ID: 114485
  • Name: (2R)-1-methoxy-3-(2-nitroimidazol-1-yl)propan -2-ol
  • MW: 201.18 | Formula: C7H11N3O4
  • H donors: 1 H acceptors: 4 LogP: -0.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1nccn1C[C@H](COC)O
  • InChi: 1S/C7H11N3O4/c1-14-5-6(11)4-9-3-2-8-7(9)10(12)13/h2-3,6,11H,4-5H2,1H3/t6-/m1/s1
  • InChiKey: OBBCSXFCDPPXOL-ZCFIWIBFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-1-methoxy-3-(2-nitro-1-imidazolyl)-2-propanol
  • Misonidazole
  • (2R)-1-methoxy-3-(2-nitro-1-imidazolyl)propan-2-ol
  • 95120-45-9

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum tubulin beta chain 0.0314 0.119 0.8229
Leishmania major beta tubulin 0.0314 0.119 0.2894
Schistosoma mansoni tubulin subunit beta 0.0314 0.119 0.2894
Trichomonas vaginalis tubulin beta chain, putative 0.01 0.0336 0.0276
Loa Loa (eye worm) BEN-1 protein 0.0314 0.119 0.5041
Echinococcus multilocularis lipoxygenase domain containing protein 0.0162 0.0584 0.2471
Brugia malayi CHE-14 protein 0.0055 0.0156 0.0661
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0123 0.0427 0.2945
Mycobacterium tuberculosis Hypothetical protein 0.0056 0.0159 0.0198
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0117 0.0403 0.0504
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.005 0.021
Loa Loa (eye worm) tubulin beta chain 0.0077 0.0243 0.1027
Schistosoma mansoni tyrosine kinase 0.0058 0.017 0.041
Echinococcus multilocularis carbonic anhydrase 0.0028 0.005 0.0204
Leishmania major beta tubulin 0.0314 0.119 0.2894
Leishmania major zeta tubulin, putative 0.0077 0.0243 0.0589
Echinococcus multilocularis tubulin alpha chain 0.0253 0.0945 0.4004
Loa Loa (eye worm) hypothetical protein 0.0253 0.0945 0.4004
Loa Loa (eye worm) tubulin alpha chain 0.0253 0.0945 0.4004
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.0945 0.0889
Plasmodium falciparum alpha tubulin 1 0.0253 0.0945 0.6535
Echinococcus multilocularis carbonic anhydrase 0.0028 0.005 0.0204
Schistosoma mansoni tyrosine kinase 0.0128 0.0447 0.1085
Brugia malayi Dihydrofolate reductase 0.0608 0.2358 1
Brugia malayi Tubulin beta chain 0.01 0.0336 0.1425
Brugia malayi Doublecortin family protein 0.0162 0.0584 0.2475
Trypanosoma cruzi zeta tubulin, putative 0.0077 0.0243 0.1676
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0207 0.0501
Echinococcus granulosus Tubulin alpha 1 chain 0.0253 0.0945 0.4004
Loa Loa (eye worm) tubulin alpha-3 chain 0.0153 0.0547 0.2316
Echinococcus granulosus Tubulin beta 2C chain 0.0314 0.119 0.5041
Trichomonas vaginalis tubulin beta chain, putative 0.0314 0.119 0.1135
Brugia malayi hypothetical protein 0.0152 0.0544 0.2306
Onchocerca volvulus 0.0152 0.0544 0.3234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0132 0.0319
Echinococcus multilocularis cyclin dependent kinase 0.0031 0.0061 0.0255
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Schistosoma mansoni tyrosine kinase 0.0058 0.017 0.041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0028 0.0112
Trichomonas vaginalis tubulin alpha chain, putative 0.0177 0.0641 0.0583
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0028 0.0064
Mycobacterium ulcerans hypothetical protein 0.0116 0.0399 0.0196
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Echinococcus granulosus tubulin alpha chain 0.0253 0.0945 0.4004
Schistosoma mansoni tubulin subunit alpha 0.0253 0.0945 0.2298
Schistosoma mansoni hypothetical protein 0.0076 0.0242 0.0587
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0028 0.0112
Echinococcus multilocularis tubulin delta chain 0.0077 0.0243 0.1027
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Schistosoma mansoni tubulin subunit beta 0.0314 0.119 0.2894
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0112
Trypanosoma cruzi tubulin delta chain 0.0077 0.0243 0.1676
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0028 0.0117
Loa Loa (eye worm) tubulin beta chain 0.0314 0.119 0.5041
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0028 0.0117
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0031 0.0061 0.0415
Echinococcus granulosus peroxisome assembly protein 26 0.0253 0.0945 0.4004
Mycobacterium tuberculosis Cell division protein FtsZ 0.0077 0.0243 0.0304
Entamoeba histolytica carbonic anhydrase, putative 0.1047 0.4107 1
Brugia malayi tubulin alpha-2 chain 0.0253 0.0945 0.4007
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.2016 0.7966 1
Leishmania major beta tubulin 0.0314 0.119 0.2894
Echinococcus multilocularis Tubulin beta 2C chain 0.0314 0.119 0.5041
Loa Loa (eye worm) tubulin alpha 2 0.0176 0.064 0.2709
Echinococcus multilocularis tubulin alpha 1C chain 0.0253 0.0945 0.4004
Echinococcus granulosus Protein patched homolog 1 0.0055 0.0156 0.0656
Leishmania major gamma-tubulin 0.0177 0.0641 0.1558
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0028 0.005 0.0204
Trypanosoma brucei beta tubulin 0.0177 0.0641 0.4431
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0207 0.0878
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0133 0.0467 0.0266
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0075 0.0317
Plasmodium vivax protein kinase Crk2 0.0031 0.0061 0.0415
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0128 0.0447 0.189
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.1202
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0028 0.0064
Leishmania major beta tubulin 0.0314 0.119 0.2894
Trichomonas vaginalis tubulin epsilon chain, putative 0.0253 0.0945 0.0889
Leishmania major beta tubulin 0.0314 0.119 0.2894
Schistosoma mansoni jun-related protein 0.0076 0.0242 0.0587
Entamoeba histolytica tubulin family protein 0.0314 0.119 0.2788
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0028 0.0112
Leishmania major beta tubulin 0.0314 0.119 0.2894
Trypanosoma brucei alpha tubulin 0.0253 0.0945 0.6535
Echinococcus granulosus tubulin gamma 1 chain 0.0177 0.0641 0.2715
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0244
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0001 0.0006
Loa Loa (eye worm) thymidylate synthase 0.0117 0.0403 0.1704
Loa Loa (eye worm) hypothetical protein 0.0133 0.0467 0.1976
Brugia malayi hypothetical protein 0.0162 0.0584 0.2475
Brugia malayi hypothetical protein 0.0162 0.0584 0.2475
Brugia malayi thymidylate synthase 0.0117 0.0403 0.1709
Echinococcus granulosus Tubulin beta 2C chain 0.0314 0.119 0.5041
Echinococcus granulosus tubulin alpha chain 0.0253 0.0945 0.4004
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0243 0.0183
Echinococcus multilocularis epidermal growth factor receptor 0.0058 0.017 0.0714
Echinococcus granulosus tubulin alpha 1C chain 0.0253 0.0945 0.4004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0132 0.0319
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0028 0.0117
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0417 0.1762
Echinococcus granulosus alpha tubulin 0.0253 0.0945 0.4004
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0207 0.0501
Toxoplasma gondii alpha-tubulin I, putative 0.0253 0.0945 0.6535
Loa Loa (eye worm) alpha-tubulin 0.0253 0.0945 0.4004
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.005 0.0117
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0128 0.0447 0.189
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.0073
Schistosoma mansoni tubulin subunit beta 0.0314 0.119 0.2894
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0133 0.0467 0.1134
Brugia malayi hypothetical protein 0.0056 0.0159 0.0675
Echinococcus multilocularis protein patched 0.0055 0.0156 0.0656
Leishmania major beta tubulin 0.0314 0.119 0.2894
Echinococcus granulosus RUN 0.0162 0.0584 0.2471
Loa Loa (eye worm) TK/INSR protein kinase 0.0128 0.0447 0.189
Echinococcus granulosus tubulin subunit TubB 0.0253 0.0945 0.4004
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0067 0.0207 0.1421
Echinococcus multilocularis tubulin alpha chain 0.0253 0.0945 0.4004
Loa Loa (eye worm) tubulin beta-1 chain 0.0314 0.119 0.5041
Echinococcus multilocularis dihydrofolate reductase 0.0608 0.2358 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0031 0.0061 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0207 0.0501
Echinococcus multilocularis tubulin subunit beta 0.0314 0.119 0.5041
Plasmodium vivax tubulin gamma chain, putative 0.0177 0.0641 0.4431
Plasmodium vivax sulfate transporter, putative 0.0067 0.0207 0.1421
Schistosoma mansoni tubulin subunit alpha 0.0077 0.0243 0.059
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0031 0.0061 0.0255
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0028 0.0112
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0028 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0061 0.0146
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0204
Echinococcus granulosus tubulin subunit beta 0.0314 0.119 0.5041
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0067 0.0207 0.1421
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0123 0.0427 0.1805
Schistosoma mansoni tubulin subunit alpha 0.0253 0.0945 0.2298
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0028 0.0112
Echinococcus multilocularis cyclin dependent kinase 5 0.0031 0.0061 0.0255
Schistosoma mansoni hypothetical protein 0.0171 0.0617 0.15
Echinococcus granulosus tubulin alpha chain 0.0253 0.0945 0.4004
Brugia malayi Tubulin beta-1 chain 0.0314 0.119 0.5044
Loa Loa (eye worm) tubulin beta-4 chain 0.0314 0.119 0.5041
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0077 0.0243 0.0183
Onchocerca volvulus Peroxidase homolog 0.0082 0.0265 0.149
Echinococcus multilocularis Tubulin beta 2C chain 0.0314 0.119 0.5041
Echinococcus multilocularis tubulin beta 1 chain 0.0314 0.119 0.5041
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0133 0.0467 0.3224
Echinococcus granulosus lipoxygenase domain containing protein 0.0162 0.0584 0.2471
Onchocerca volvulus 0.0082 0.0265 0.149
Onchocerca volvulus Putative sulfate transporter 0.0423 0.1624 1
Schistosoma mansoni tyrosine kinase 0.0057 0.0165 0.04
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0132 0.0319
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0067 0.0207 0.1421
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.0945 0.0889
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0123 0.0427 0.1036
Echinococcus multilocularis carbonic anhydrase 0.0028 0.005 0.0204
Plasmodium falciparum tubulin epsilon chain, putative 0.0177 0.0641 0.4431
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.0073
Loa Loa (eye worm) carbonic anhydrase 3 0.0123 0.0427 0.1805
Echinococcus multilocularis tubulin alpha 1C chain 0.0253 0.0945 0.4004
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0176 0.064 0.2709
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0204
Echinococcus granulosus beta tubulin 0.0314 0.119 0.5041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0028 0.0117
Echinococcus granulosus carbonic anhydrase 0.0028 0.005 0.0204
Brugia malayi nuclear hormone receptor 0.0022 0.0028 0.0117
Plasmodium vivax delta tubulin, putative 0.0077 0.0243 0.1676
Schistosoma mansoni tyrosine kinase 0.0057 0.0165 0.04
Echinococcus granulosus tubulin epsilon chain 0.0177 0.0641 0.2715
Schistosoma mansoni polycystin 1-related 0.0162 0.0584 0.1418
Onchocerca volvulus 0.01 0.0336 0.1932
Echinococcus multilocularis sterol regulatory element binding protein 0.0055 0.0156 0.0656
Onchocerca volvulus 0.0423 0.1624 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0028 0.0064
Brugia malayi MH2 domain containing protein 0.012 0.0417 0.1767
Schistosoma mansoni tyrosine kinase 0.0058 0.017 0.041
Onchocerca volvulus 0.0117 0.0403 0.2352
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.005 0.0117
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0207 0.0872
Echinococcus granulosus Polycystic kidney disease protein 0.0162 0.0584 0.2471
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0091 0.038
Brugia malayi Tubulin alpha chain 0.0253 0.0945 0.4007
Loa Loa (eye worm) TK/EGFR protein kinase 0.0058 0.017 0.0714
Schistosoma mansoni loxhd1 0.0162 0.0584 0.1418
Trichomonas vaginalis tubulin gamma chain, putative 0.0314 0.119 0.1135
Brugia malayi beta-tubulin, identical 0.0314 0.119 0.5044
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0378 0.1445 1
Trichomonas vaginalis tubulin, putative 0.01 0.0336 0.0276
Schistosoma mansoni hypothetical protein 0.0038 0.0091 0.0218
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0077 0.0243 0.1676
Plasmodium vivax multidomain scavenger receptor, putative 0.0162 0.0584 0.4032
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0177 0.0641 0.4431
Trypanosoma cruzi epsilon tubulin, putative 0.0177 0.0641 0.4431
Echinococcus granulosus carbonic anhydrase 0.0028 0.005 0.0204
Schistosoma mansoni tubulin subunit beta 0.0077 0.0243 0.059
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0133 0.0467 0.1976
Schistosoma mansoni lipoxygenase 0.0293 0.1106 0.269
Giardia lamblia Alpha-tubulin 0.0253 0.0945 0.7832
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0062 0.0186 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.2526 1 1
Leishmania major beta tubulin 0.0314 0.119 0.2894
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0028 0.0117
Trypanosoma brucei beta tubulin 0.0314 0.119 0.8229
Trichomonas vaginalis tubulin, putative 0.0314 0.119 0.1135
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0067 0.0207 0.1421
Loa Loa (eye worm) beta-tubulin 0.0314 0.119 0.5041
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0028 0.0117
Trypanosoma brucei beta tubulin 0.0314 0.119 0.8229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0093 0.0309 0.1306
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.0945 0.0889
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0112
Onchocerca volvulus 0.0162 0.0584 0.3484
Trypanosoma brucei tubulin delta chain 0.0077 0.0243 0.1676
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0058 0.017 0.0714
Trichomonas vaginalis tubulin gamma chain, putative 0.0077 0.0243 0.0183
Echinococcus multilocularis epidermal growth factor receptor 0.0058 0.017 0.0714
Echinococcus granulosus carbonic anhydrase 0.0028 0.005 0.0204
Trypanosoma brucei epsilon tubulin 0.0177 0.0641 0.4431
Trichomonas vaginalis tubulin, putative 0.01 0.0336 0.0276
Brugia malayi dihydrofolate reductase family protein 0.0608 0.2358 1
Brugia malayi ecdysteroid receptor 0.0022 0.0028 0.0117
Echinococcus granulosus tubulin alpha chain 0.0253 0.0945 0.4004
Echinococcus granulosus thymidylate synthase 0.0117 0.0403 0.1704
Loa Loa (eye worm) hypothetical protein 0.007 0.0215 0.0908
Leishmania major beta tubulin 0.0314 0.119 0.2894
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0242 0.102
Echinococcus granulosus Tubulin beta 2C chain 0.0314 0.119 0.5041
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0117 0.0403 0.0413
Echinococcus granulosus tubulin alpha chain 0.0253 0.0945 0.4004
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0207 0.0872
Plasmodium vivax tubulin alpha chain, putative 0.0253 0.0945 0.6535
Echinococcus granulosus sterol regulatory element binding protein 0.0055 0.0156 0.0656
Leishmania major beta tubulin 0.0314 0.119 0.2894
Echinococcus multilocularis tubulin alpha 3 chain 0.0253 0.0945 0.4004
Echinococcus granulosus cyclin dependent kinase 1 0.0031 0.0061 0.0255
Giardia lamblia Epsilon tubulin 0.0077 0.0243 0.1614
Schistosoma mansoni tubulin subunit alpha 0.0253 0.0945 0.2298
Plasmodium falciparum alpha tubulin 2 0.0253 0.0945 0.6535
Trypanosoma brucei alpha tubulin 0.0253 0.0945 0.6535
Echinococcus multilocularis Tubulin alpha 1 chain 0.0253 0.0945 0.4004
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0123 0.0427 0.1036
Brugia malayi Tubulin gamma chain 0.0177 0.0641 0.2719
Giardia lamblia Delta tubulin 0.0077 0.0243 0.1614
Echinococcus multilocularis tubulin alpha 0.0177 0.0641 0.2715
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0028 0.0117
Toxoplasma gondii alpha tubulin TUBA1 0.0253 0.0945 0.6535
Onchocerca volvulus 0.0082 0.0265 0.149
Plasmodium vivax tubulin alpha chain, putative 0.0253 0.0945 0.6535
Trypanosoma cruzi zeta tubulin, putative 0.0077 0.0243 0.1676
Brugia malayi nuclear receptor NHR-88 0.0022 0.0028 0.0117
Loa Loa (eye worm) tubulin alpha-2 chain 0.0253 0.0945 0.4004
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0123 0.0427 0.1809
Giardia lamblia Beta tubulin 0.0314 0.119 1
Schistosoma mansoni hypothetical protein 0.0162 0.0584 0.1418
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0028 0.0112
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1047 0.4107 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0177 0.0641 0.0583
Brugia malayi Protein kinase domain containing protein 0.0128 0.0447 0.1895
Trichomonas vaginalis tubulin, putative 0.0077 0.0243 0.0183
Loa Loa (eye worm) hypothetical protein 0.0034 0.0075 0.0311
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0608 0.2358 0.2197
Trypanosoma cruzi cdc2-related kinase 3 0.0031 0.0061 0.0415
Loa Loa (eye worm) alpha-tubulin 0.0253 0.0945 0.4004
Trypanosoma brucei alpha tubulin 0.0253 0.0945 0.6535
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0028 0.0117
Echinococcus granulosus beta tubulin 0.0314 0.119 0.5041
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0112
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0265 0.1125
Schistosoma mansoni tubulin subunit beta 0.0314 0.119 0.2894
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0176 0.064 0.0582
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Loa Loa (eye worm) hypothetical protein 0.0176 0.064 0.2709
Echinococcus multilocularis Tubulin alpha 1 chain 0.0253 0.0945 0.4004
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0028 0.0117
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0489 0.1885 0.2365
Echinococcus granulosus geminin 0.0171 0.0617 0.2613
Onchocerca volvulus Peroxidasin homolog 0.0082 0.0265 0.149
Loa Loa (eye worm) RNA binding protein 0.0067 0.0207 0.0872
Brugia malayi hypothetical protein 0.007 0.0218 0.0924
Echinococcus multilocularis carbonic anhydrase II 0.0123 0.0427 0.1805
Giardia lamblia Gamma tubulin 0.0177 0.0641 0.514
Schistosoma mansoni tubulin subunit beta 0.0314 0.119 0.2894
Schistosoma mansoni rab6-interacting 0.0162 0.0584 0.1418
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0028 0.0117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0028 0.0112
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0265 0.112
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.0945 0.0889
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0138 0.058
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0133 0.0467 0.1976
Echinococcus granulosus tar DNA binding protein 0.0067 0.0207 0.0872
Trichomonas vaginalis conserved hypothetical protein 0.2526 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0028 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0207 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0159 0.0098
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0133 0.0467 0.3224
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0112
Schistosoma mansoni hypothetical protein 0.0028 0.005 0.0117
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0207 0.0872
Echinococcus multilocularis protein dispatched 1 0.0055 0.0156 0.0656
Trichomonas vaginalis tubulin alpha chain, putative 0.01 0.0336 0.0276
Loa Loa (eye worm) blistered cuticle protein 3 0.0082 0.0265 0.112
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0031 0.0061 0.0255
Schistosoma mansoni alpha tubulin 0.0253 0.0945 0.2298
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0028 0.0112
Schistosoma mansoni tyrosine kinase 0.0128 0.0447 0.1085
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0028 0.0064
Echinococcus multilocularis tubulin subunit TubB 0.0253 0.0945 0.4004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0028 0.0064
Echinococcus multilocularis 0.0017 0.0005 0.0014
Entamoeba histolytica tubulin gamma chain 0.0177 0.0641 0.1433
Echinococcus granulosus lipoxygenase domain containing protein 0.0162 0.0584 0.2471
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0417 0.1762
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.0073
Brugia malayi Protein kinase domain containing protein 0.0031 0.0061 0.026
Trypanosoma cruzi cdc2-related kinase 3 0.0031 0.0061 0.0415
Brugia malayi cell division control protein 2 homolog 0.0031 0.0061 0.026
Echinococcus granulosus tubulin beta 1 chain 0.0314 0.119 0.5041
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0056 0.0159 0.1093
Echinococcus multilocularis tubulin gamma 1 chain 0.0177 0.0641 0.2715
Echinococcus multilocularis tubulin alpha chain 0.0253 0.0945 0.4004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0132 0.0555
Onchocerca volvulus Dual oxidase homolog 0.0082 0.0265 0.149
Echinococcus granulosus carbonic anhydrase II 0.0123 0.0427 0.1805
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0156 0.0095
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0028 0.0112
Echinococcus multilocularis thymidylate synthase 0.0117 0.0403 0.1704
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Brugia malayi alpha-tubulin 0.0253 0.0945 0.4007
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Trypanosoma brucei cdc2-related kinase 1 0.0031 0.0061 0.0415
Leishmania major beta tubulin 0.0314 0.119 0.2894
Echinococcus multilocularis tubulin epsilon chain 0.0177 0.0641 0.2715
Echinococcus granulosus Tubulin beta 2C chain 0.0314 0.119 0.5041
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0062 0.0186 0.0126
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Loa Loa (eye worm) hypothetical protein 0.0153 0.0547 0.2316
Schistosoma mansoni patched 1 0.0055 0.0156 0.0376
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0265 0.112
Brugia malayi Blistered cuticle protein 3 0.0082 0.0265 0.1125
Trichomonas vaginalis tubulin epsilon chain, putative 0.0077 0.0243 0.0183
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.005 0.0117
Brugia malayi TAR-binding protein 0.0067 0.0207 0.0878
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0028 0.0117
Echinococcus multilocularis Niemann Pick C1 protein 0.0055 0.0156 0.0656
Toxoplasma gondii beta-1 tubulin, putative 0.0314 0.119 0.8229
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0112
Echinococcus multilocularis RUN 0.0162 0.0584 0.2471
Leishmania major beta tubulin 0.0314 0.119 0.2894
Trypanosoma cruzi beta tubulin, putative 0.0314 0.119 0.8229
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0378 0.1445 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0162 0.0584 0.2471
Trichomonas vaginalis tubulin alpha chain, putative 0.01 0.0336 0.0276
Schistosoma mansoni dihydrofolate reductase 0.0608 0.2358 0.574
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0265 0.1125
Echinococcus multilocularis cyclin dependent kinase 1 0.0031 0.0061 0.0255
Echinococcus multilocularis Tubulin alpha 1 chain 0.0253 0.0945 0.4004
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.005 0.021
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0133 0.0467 0.1134
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Plasmodium vivax tubulin beta chain, putative 0.0314 0.119 0.8229
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0242 0.102
Mycobacterium ulcerans thymidylate synthase 0.0117 0.0403 0.02
Leishmania major beta tubulin 0.0314 0.119 0.2894
Echinococcus granulosus tubulin alpha 3 chain 0.0253 0.0945 0.4004
Echinococcus granulosus peroxidasin 0.0082 0.0265 0.112
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0062 0.0186 0.1107
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0117 0.0403 0.0978
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0028 0.0117
Echinococcus granulosus epidermal growth factor receptor 0.0058 0.017 0.0714
Echinococcus multilocularis lipoxygenase domain containing protein 0.0162 0.0584 0.2471
Brugia malayi RNA binding protein 0.0067 0.0207 0.0878
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0378 0.1445 1
Entamoeba histolytica tubulin alpha-1 chain 0.0253 0.0945 0.2184
Giardia lamblia Beta tubulin 0.0314 0.119 1
Echinococcus granulosus cyclin dependent kinase 0.0031 0.0061 0.0255
Echinococcus multilocularis beta tubulin 0.0314 0.119 0.5041
Echinococcus multilocularis geminin 0.0171 0.0617 0.2613
Echinococcus multilocularis peroxisome assembly protein 26 0.0253 0.0945 0.4004
Trichomonas vaginalis tubulin epsilon chain, putative 0.0314 0.119 0.1135
Trichomonas vaginalis tubulin gamma chain, putative 0.0177 0.0641 0.0583
Schistosoma mansoni tyrosine kinase 0.0057 0.0165 0.04
Echinococcus multilocularis Tubulin beta 2C chain 0.0314 0.119 0.5041
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0028 0.0112
Brugia malayi Protein kinase domain containing protein 0.0071 0.022 0.0931
Trypanosoma cruzi alpha tubulin, putative 0.0253 0.0945 0.6535
Echinococcus multilocularis tubulin alpha chain 0.0253 0.0945 0.4004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0028 0.0064
Loa Loa (eye worm) hypothetical protein 0.0162 0.0584 0.2471
Trichomonas vaginalis tubulin alpha chain, putative 0.0314 0.119 0.1135
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0243 0.0183
Brugia malayi steroid hormone receptor 0.0022 0.0028 0.0117
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Trypanosoma brucei epsilon tubulin 0.0177 0.0641 0.4431
Schistosoma mansoni carbonic anhydrase 0.0028 0.005 0.0117
Brugia malayi isocitrate dehydrogenase 0.0016 0.0001 0.0006
Echinococcus multilocularis tubulin alpha chain 0.0253 0.0945 0.4004
Schistosoma mansoni tubulin subunit delta 0.0077 0.0243 0.059
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0093 0.0309 0.1306
Echinococcus granulosus Tubulin alpha 1 chain 0.0253 0.0945 0.4004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0028 0.0112
Treponema pallidum ATP-binding protein (ylxH-1) 0.0453 0.1741 1
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0123 0.0427 0.1809
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0028 0.0112
Schistosoma mansoni alpha tubulin 0.0253 0.0945 0.2298
Giardia lamblia Alpha-tubulin 0.0253 0.0945 0.7832
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0077 0.0243 0.5
Toxoplasma gondii beta tubulin 0.0314 0.119 0.8229
Echinococcus multilocularis hypothetical protein 0.0253 0.0945 0.4004
Echinococcus granulosus tubulin alpha 3 chain 0.0253 0.0945 0.4004
Loa Loa (eye worm) tubulin alpha 2 0.0076 0.0242 0.1021
Onchocerca volvulus 0.0162 0.0584 0.3484
Plasmodium falciparum tubulin delta chain, putative 0.0077 0.0243 0.1676
Echinococcus granulosus tubulin alpha 0.0177 0.0641 0.2715
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0077 0.0243 0.1676
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0112
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0028 0.0112
Brugia malayi Tubulin alpha-2 chain 0.0253 0.0945 0.4007
Trypanosoma brucei alpha tubulin, putative 0.01 0.0336 0.2317
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0253 0.0945 0.0889
Brugia malayi tubulin alpha chain - mouse 0.0253 0.0945 0.4007
Trypanosoma cruzi cdc2-related kinase 1 0.0031 0.0061 0.0415
Onchocerca volvulus Peroxidase homolog 0.0082 0.0265 0.149
Mycobacterium ulcerans cell division protein FtsZ 0.0077 0.0243 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0028 0.0112
Brugia malayi Furin-like cysteine rich region family protein 0.0058 0.017 0.0719
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0028 0.0064
Leishmania major carbonic anhydrase family protein, putative 0.1047 0.4107 1
Leishmania major epsilon tubulin, putative 0.0177 0.0641 0.1558
Loa Loa (eye worm) hypothetical protein 0.0152 0.0544 0.2302
Schistosoma mansoni tubulin subunit gamma 0.0177 0.0641 0.1558
Trypanosoma brucei epsilon tubulin 0.0177 0.0641 0.4431
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0028 0.0112
Trichomonas vaginalis tubulin epsilon chain, putative 0.0253 0.0945 0.0889
Schistosoma mansoni alpha tubulin 0.0253 0.0945 0.2298
Trypanosoma cruzi tubulin gamma chain 0.0177 0.0641 0.4431
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.005 0.021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0132 0.0555
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0265 0.112
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0378 0.1445 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0314 0.119 0.5041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0028 0.0112
Giardia lamblia Beta tubulin 0.0314 0.119 1
Brugia malayi Cell division protein ftsZ 0.0077 0.0243 0.1032
Echinococcus granulosus tubulin delta chain 0.0077 0.0243 0.1027
Trypanosoma brucei cdc2-related kinase 3 0.0031 0.0061 0.0415
Plasmodium falciparum LCCL domain-containing protein 0.0162 0.0584 0.4032
Loa Loa (eye worm) tubulin alpha chain 0.0253 0.0945 0.4004
Leishmania major beta tubulin 0.0314 0.119 0.2894
Mycobacterium leprae Probable transmembrane transport protein 0.0489 0.1885 0.4248
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0133 0.0467 0.198
Echinococcus multilocularis cyclin dependent kinase 1 0.0031 0.0061 0.0255
Onchocerca volvulus Chorion peroxidase homolog 0.0082 0.0265 0.149
Echinococcus multilocularis beta tubulin 0.0314 0.119 0.5041
Echinococcus multilocularis Tubulin beta 2C chain 0.0314 0.119 0.5041
Schistosoma mansoni hypothetical protein 0.0034 0.0075 0.0179
Schistosoma mansoni peroxidasin 0.0082 0.0265 0.0643
Schistosoma mansoni peroxidasin 0.0082 0.0265 0.0643
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0028 0.0117
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0028 0.0064
Leishmania major delta tubulin, putative 0.0077 0.0243 0.0589
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0585 0.2268 0.9617
Trichomonas vaginalis tubulin epsilon chain, putative 0.0314 0.119 0.1135
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0091 0.038
Trypanosoma brucei alpha tubulin 0.0253 0.0945 0.6535
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0091 0.0218
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0999 0.3919 0.4918
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0028 0.0064
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.005 0.021
Echinococcus granulosus cyclin dependent kinase 5 0.0031 0.0061 0.0255
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0204
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0265 0.1125
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0055 0.0156 0.0656
Loa Loa (eye worm) tubulin beta-2A chain 0.0314 0.119 0.5041
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0138 0.0585
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0055 0.0156 0.0376
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0265 0.1125
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0061 0.0146
Brugia malayi Peroxidasin 0.0082 0.0265 0.1125
Leishmania major beta tubulin 0.0314 0.119 0.2894
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0585 0.2268 0.9617
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0028 0.0117
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0608 0.2358 0.5473
Echinococcus multilocularis insulin receptor 0.0128 0.0447 0.189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0028 0.0112
Schistosoma mansoni carbonic anhydrase 0.1047 0.4107 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0138 0.0585
Entamoeba histolytica tubulin alpha chain, putative 0.0253 0.0945 0.2184
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0378 0.1445 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0031 0.0061 0.0255
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.01 0.0336 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0112
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0001 0.0006
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0123 0.0427 0.2945
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0028 0.0117
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Brugia malayi hypothetical protein 0.0082 0.0265 0.1125
Brugia malayi Tubulin beta chain 0.0077 0.0243 0.1032
Trypanosoma brucei beta tubulin 0.0314 0.119 0.8229
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0112
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.005 0.021
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0028 0.0064
Loa Loa (eye worm) doublecortin family protein 0.0162 0.0584 0.2471
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0132 0.0555
Mycobacterium ulcerans carbonic anhydrase 0.1047 0.4107 0.3983
Echinococcus granulosus epidermal growth factor receptor 0.0058 0.017 0.0714
Trypanosoma brucei zeta tubulin 0.0077 0.0243 0.1676
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0028 0.0112
Toxoplasma gondii hypothetical protein 0.0028 0.005 0.0333
Brugia malayi bZIP transcription factor family protein 0.0093 0.0309 0.1311
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0062 0.0186 0.0126
Echinococcus granulosus tubulin alpha 1C chain 0.0253 0.0945 0.4004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0132 0.0555
Loa Loa (eye worm) dihydrofolate reductase 0.0608 0.2358 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0028 0.0117
Brugia malayi Tubulin alpha-2 chain 0.0253 0.0945 0.4007
Onchocerca volvulus 0.007 0.0218 0.1193
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.0945 0.0889
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Leishmania major beta tubulin 0.0314 0.119 0.2894
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0132 0.0561
Schistosoma mansoni tubulin subunit epsilon 0.0177 0.0641 0.1558
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0314 0.119 0.5041
Loa Loa (eye worm) hypothetical protein 0.0162 0.0584 0.2471
Echinococcus granulosus Tubulin alpha 1 chain 0.0253 0.0945 0.4004
Onchocerca volvulus Peroxidasin homolog 0.0082 0.0265 0.149
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0153 0.0547 0.0489
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0378 0.1445 0.3516
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0265 0.112
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0133 0.0467 0.3224
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0536 0.2074 0.2602
Schistosoma mansoni tubulin subunit beta 0.0314 0.119 0.2894
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0031 0.0061 0.0146
Brugia malayi hypothetical protein 0.0038 0.0091 0.0385
Echinococcus granulosus Niemann Pick C1 protein 0.0055 0.0156 0.0656
Loa Loa (eye worm) tubulin gamma chain 0.0177 0.0641 0.2715
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0207 0.0501
Plasmodium falciparum tubulin gamma chain 0.0177 0.0641 0.4431
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0608 0.2358 0.2959
Loa Loa (eye worm) hypothetical protein 0.0055 0.0156 0.0656
Leishmania major carbonic anhydrase-like protein 0.0123 0.0427 0.1036
Trypanosoma brucei beta tubulin 0.0314 0.119 0.8229
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0028 0.0112
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0028 0.0112
Trypanosoma brucei tubulin gamma chain 0.0177 0.0641 0.4431
Chlamydia trachomatis dihydrofolate reductase 0.0608 0.2358 1
Brugia malayi Tubulin alpha chain 0.0077 0.0243 0.1032
Plasmodium vivax tubulin epsilon chain, putative 0.0177 0.0641 0.4431
Loa Loa (eye worm) hypothetical protein 0.0082 0.0265 0.112
Echinococcus multilocularis peroxidasin 0.0082 0.0265 0.112
Onchocerca volvulus 0.0082 0.0265 0.149
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0067 0.0207 0.1421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0028 0.0112
Plasmodium falciparum protein kinase 5 0.0031 0.0061 0.0415
Trichomonas vaginalis tubulin alpha chain, putative 0.01 0.0336 0.0276
Entamoeba histolytica tubulin family protein 0.0314 0.119 0.2788
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0028 0.0064
Plasmodium falciparum carbonic anhydrase 0.0028 0.005 0.0333
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0132 0.0555
Echinococcus multilocularis tubulin alpha 3 chain 0.0253 0.0945 0.4004
Schistosoma mansoni coup transcription factor 0.0022 0.0028 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0028 0.0112
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.0945 0.0889
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0028 0.0112
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Schistosoma mansoni lipoxygenase 0.0585 0.2268 0.552
Echinococcus granulosus insulin receptor 0.0128 0.0447 0.189
Echinococcus granulosus Tubulin beta 2C chain 0.0314 0.119 0.5041
Loa Loa (eye worm) BEN-1 protein 0.0314 0.119 0.5041
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0028 0.0112
Trypanosoma cruzi tubulin delta chain 0.0077 0.0243 0.1676
Echinococcus granulosus dihydrofolate reductase 0.0608 0.2358 1
Leishmania major beta tubulin 0.0314 0.119 0.2894
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0028 0.0112
Toxoplasma gondii beta-tubulin, putative 0.0314 0.119 0.8229
Leishmania major alpha tubulin 0.0253 0.0945 0.2298
Echinococcus multilocularis Tubulin beta 2C chain 0.0314 0.119 0.5041
Schistosoma mansoni hypothetical protein 0.0171 0.0617 0.15
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.058
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0265 0.1125
Echinococcus multilocularis jun protein 0.0093 0.0309 0.1306
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0031 0.0061 0.0146
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0001 0.0006
Trypanosoma cruzi epsilon tubulin, putative 0.0177 0.0641 0.4431
Entamoeba histolytica hypothetical protein 0.0038 0.0091 0.0073
Leishmania major beta tubulin 0.0314 0.119 0.2894
Trypanosoma brucei carbonic anhydrase-like protein 0.0123 0.0427 0.2945
Loa Loa (eye worm) tubulin alpha 2 0.0176 0.064 0.2709
Echinococcus granulosus jun protein 0.0093 0.0309 0.1306
Trypanosoma cruzi cdc2-related kinase 1 0.0031 0.0061 0.0415
Schistosoma mansoni rab6-interacting 0.0162 0.0584 0.1418
Trypanosoma brucei zeta tubulin, putative 0.0077 0.0243 0.1676

Activities

Activity type Activity value Assay description Source Reference
Partition coefficient = 0.41 Compound was tested for the partition coefficient between octanol and water. ChEMBL. 2066990

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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