Detailed information for compound 1155653

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.41 | Formula: C19H25F3N2O
  • H donors: 0 H acceptors: 1 LogP: 3.94 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N([C@H]1CCCC[C@]21CCCN2C)C)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C19H25F3N2O/c1-23-13-5-12-18(23)11-4-3-6-16(18)24(2)17(25)14-7-9-15(10-8-14)19(20,21)22/h7-10,16H,3-6,11-13H2,1-2H3/t16-,18+/m0/s1
  • InChiKey: HUFBLXFPRKMQOF-FUHWJXTLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0051 0.0204
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.0065
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.004 0.0087 0.0368
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.002 0.0044
Loa Loa (eye worm) papain family cysteine protease containing protein 0.004 0.0087 0.0368
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.0442 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0362 0.1563
Entamoeba histolytica cysteine protease, putative 0.004 0.0087 0.2068
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.002 0.0387
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0322 0.1139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Echinococcus granulosus cathepsin L cysteine proteinase 0.004 0.0087 0.0348
Mycobacterium ulcerans hypothetical protein 0.0042 0.0094 0.0063
Mycobacterium ulcerans AcrR family transcriptional regulator 0.3155 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0442 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0031 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0087 0.0236
Plasmodium vivax vivapain-1 0.002 0.0026 0.0787
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0187 0.0744
Brugia malayi jmjC domain containing protein 0.0073 0.0193 0.0827
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0084 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0087 0.0236
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.002 0.0064
Echinococcus granulosus zinc finger protein 0.0025 0.004 0.016
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0094 0.0063
Leishmania major cathepsin L-like protease 0.004 0.0087 0.1636
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0026 0.053
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0187 0.5991
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.002 0.0065
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0095 0.031
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.002 0.0387
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.002 0.0377
Brugia malayi jmjC domain containing protein 0.0018 0.002 0.0072
Plasmodium vivax JmjC domain containing protein 0.0018 0.002 0.056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0031 0.0641
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0322 0.1139
Loa Loa (eye worm) hypothetical protein 0.0062 0.0158 0.0672
Loa Loa (eye worm) intermediate filament protein 0.0063 0.0161 0.0688
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0189 0.0753
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0193 0.0768
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0099 0.2441
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0006 0.0021
Toxoplasma gondii exonuclease III APE 0.0022 0.0031 0.0415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0442 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0033 0.0107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.0065
Brugia malayi Pre-SET motif family protein 0.0735 0.2301 1
Leishmania major cathepsin L-like protease 0.0151 0.0442 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.0322 0.727
Leishmania major cathepsin L-like protease 0.004 0.0087 0.1636
Echinococcus multilocularis phd:f box containing protein 0.0018 0.002 0.0064
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0189 0.0618
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0087 0.0236
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.002 0.0015
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0031 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0026 0.0192
Onchocerca volvulus 0.0837 0.2624 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0087 0.0236
Echinococcus granulosus neuropeptide receptor A26 0.054 0.168 0.6688
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0094 0.1798
Leishmania major cysteine peptidase A (CPA) 0.004 0.0087 0.1636
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0026 0.0105
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0094 0.0262
Echinococcus multilocularis cpg binding protein 0.0037 0.0081 0.0263
Onchocerca volvulus 0.0033 0.0067 0.0084
Schistosoma mansoni hypothetical protein 0.0018 0.0018 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0113 0.0322 0.1283
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.0368
Echinococcus granulosus cpg binding protein 0.0037 0.0081 0.0321
Mycobacterium ulcerans TetR family transcriptional regulator 0.3155 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0362 0.1442
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0025 0.0098
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0094 0.208
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0013 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0094 0.0376
Entamoeba histolytica serine/threonine protein kinase, putative 0.0113 0.0322 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0184 0.5868
Echinococcus multilocularis lamin 0.0063 0.0161 0.0527
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.013 0.0519
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0026 0.0105
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0031 0.0123
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0322 0.1139
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0034 0.0068 0.0284
Loa Loa (eye worm) hypothetical protein 0.0042 0.0094 0.0397
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0038 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0322 0.1283
Trypanosoma cruzi major cysteine proteinase, putative 0.0119 0.0339 0.7656
Leishmania major hypothetical protein, conserved 0.0042 0.0094 0.1798
Plasmodium vivax unspecified product 0.002 0.0026 0.0787
Plasmodium vivax vivapain-2 0.004 0.0087 0.2855
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.1473 0.4814
Loa Loa (eye worm) hypothetical protein 0.0063 0.0161 0.0688
Schistosoma mansoni intermediate filament proteins 0.0063 0.0161 0.0642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0442 1
Echinococcus granulosus cathepsin l1 0.004 0.0087 0.0348
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0187 0.0156
Loa Loa (eye worm) hypothetical protein 0.0052 0.0126 0.0534
Brugia malayi Cathepsin L-like precursor 0.0027 0.0046 0.0186
Echinococcus multilocularis neuropeptide receptor A26 0.054 0.168 0.549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0442 1
Giardia lamblia Kinase, PLK 0.0113 0.0322 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0099 0.0068
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0113 0.0322 0.1053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0099 0.2176
Brugia malayi cathepsin L-like precursor 0.0027 0.0046 0.0186
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0187 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.004 0.0087 0.0236
Onchocerca volvulus Cathepsin L homolog 0.004 0.0087 0.0162
Onchocerca volvulus 0.004 0.0087 0.0162
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0033 0.013
Plasmodium falciparum cysteine proteinase falcipain 2a 0.004 0.0087 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0094 0.0308
Brugia malayi Cathepsin L-like precursor 0.004 0.0087 0.0368
Onchocerca volvulus Huntingtin homolog 0.0285 0.0869 0.3194
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.002 0.0026 0.053
Brugia malayi serine/threonine-protein kinase plk-2 0.0113 0.0322 0.1389
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0095 0.0378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0087 0.0236
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0094 0.0397
Loa Loa (eye worm) hypothetical protein 0.0042 0.0094 0.0397
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0025 0.0098
Brugia malayi beta-lactamase family protein 0.0042 0.0094 0.0397
Onchocerca volvulus 0.0063 0.0161 0.0448
Onchocerca volvulus Cathepsin L homolog 0.004 0.0087 0.0162
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.002 0.0064
Brugia malayi beta-lactamase 0.0042 0.0094 0.0397
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0063 0.0161 0.0688
Mycobacterium tuberculosis Conserved protein 0.0042 0.0094 0.0075
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0031 0.0123
Brugia malayi beta-lactamase family protein 0.0042 0.0094 0.0397
Schistosoma mansoni cpg binding protein 0.0037 0.0081 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0442 1
Onchocerca volvulus Cathepsin F homolog 0.004 0.0087 0.0162
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0067 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.002 0.0065
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.002 0.0063
Brugia malayi jmjC domain containing protein 0.0018 0.002 0.0072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.013 0.0554
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.0442 1
Loa Loa (eye worm) hypothetical protein 0.0285 0.0869 0.3769
Brugia malayi jmjC domain containing protein 0.0069 0.018 0.0769
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0031 0.0641
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.002 0.0015
Mycobacterium ulcerans lipase LipD 0.0042 0.0094 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0187 0.0156
Mycobacterium ulcerans beta-lactamase 0.0042 0.0094 0.0063
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0193 0.0827
Echinococcus granulosus microtubule associated protein 2 0.0801 0.2512 1
Schistosoma mansoni hypothetical protein 0.0475 0.1473 0.5864
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0187 0.0744
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0106 0.0299 0.119
Brugia malayi isocitrate dehydrogenase 0.0018 0.002 0.0074
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0094 0.0376
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.002 0.0078
Brugia malayi Cathepsin L-like precursor 0.004 0.0087 0.0368
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0087 0.2068
Echinococcus granulosus lamin 0.0063 0.0161 0.0642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.013 0.0519
Loa Loa (eye worm) fibroinase 0.004 0.0087 0.0368
Loa Loa (eye worm) hypothetical protein 0.0285 0.0869 0.3769
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.018 0.0588
Echinococcus multilocularis cathepsin L cysteine protease 0.004 0.0087 0.0286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.013 0.0519
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.002 0.0044
Schistosoma mansoni inositol monophosphatase 0.0043 0.0099 0.0392
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0087 0.0236
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.002 0.0044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0046 0.0186
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0094 0.0262
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.3155 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0094 0.0397
Leishmania major cathepsin L-like protease 0.004 0.0087 0.1636
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.002 0.0078
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0138 0.04 0.905
Brugia malayi Isocitrate dehydrogenase 0.0018 0.002 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.013 0.0519
Echinococcus multilocularis musashi 0.0063 0.0161 0.0527
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0094 0.0075
Mycobacterium leprae Probable lipase LipE 0.0042 0.0094 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.002 0.0072
Plasmodium vivax SET domain protein, putative 0.0106 0.0299 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0072
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0026 0.053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0442 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0193 0.0768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0031 0.1709
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0087 0.0236
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.0442 1
Echinococcus multilocularis microtubule associated protein 2 0.0801 0.2512 0.8209
Brugia malayi Cathepsin L-like precursor 0.004 0.0087 0.0368
Brugia malayi Cathepsin L-like precursor 0.004 0.0087 0.0368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0046 0.0075
Schistosoma mansoni hypothetical protein 0.0198 0.0591 0.2353
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0058 0.023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.013 0.0426
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.013 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Echinococcus granulosus cathepsin L 0.002 0.0026 0.0105
Brugia malayi Cathepsin L-like precursor 0.0027 0.0046 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0094 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Plasmodium falciparum cysteine proteinase falcipain 2b 0.004 0.0087 1
Schistosoma mansoni jumonji domain containing protein 0.0069 0.018 0.0716
Mycobacterium tuberculosis Conserved protein 0.0042 0.0094 0.0075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.0065
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0094 0.0075
Schistosoma mansoni ap endonuclease 0.0022 0.0031 0.0124
Onchocerca volvulus 0.004 0.0087 0.0162
Echinococcus multilocularis neuropeptide s receptor 0.054 0.168 0.549
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0051 0.0167
Brugia malayi Bromodomain containing protein 0.0045 0.0104 0.0438
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0006 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0442 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0072
Loa Loa (eye worm) hypothetical protein 0.0042 0.0094 0.0397
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0094 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Echinococcus granulosus phd:f box containing protein 0.0018 0.002 0.0078
Onchocerca volvulus 0.0042 0.0094 0.0188
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0031 0.0165
Onchocerca volvulus 0.0042 0.0094 0.0188
Plasmodium vivax vivapain-2 0.004 0.0087 0.2855
Onchocerca volvulus 0.0063 0.0161 0.0448
Schistosoma mansoni cathepsin F (C01 family) 0.004 0.0087 0.0348
Schistosoma mansoni protein phosphatase 2C 0.0018 0.002 0.0078
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0974 0.306 1
Onchocerca volvulus 0.0106 0.0299 0.0982
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0031 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0187 0.0744
Mycobacterium tuberculosis Conserved protein 0.0042 0.0094 0.0075
Loa Loa (eye worm) hypothetical protein 0.0027 0.0046 0.0186
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0099 0.2176
Schistosoma mansoni cathepsin s 0.0013 0.0003 0.0012
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0031 0.0307
Brugia malayi jmjC domain containing protein 0.0018 0.002 0.0072
Schistosoma mansoni kinase 0.0058 0.0145 0.0576
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0094 0.0262
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0094 0.0397
Schistosoma mansoni cpg binding protein 0.0037 0.0081 0.0321
Leishmania major hypothetical protein, conserved 0.0018 0.002 0.0034
Schistosoma mansoni inositol monophosphatase 0.0043 0.0099 0.0392
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.002 0.0064
Echinococcus granulosus geminin 0.0198 0.0591 0.2353
Trypanosoma cruzi cysteine protease, putative 0.002 0.0026 0.053
Loa Loa (eye worm) beta-lactamase 0.0042 0.0094 0.0397
Schistosoma mansoni jumonji domain containing protein 0.0018 0.002 0.0078
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0026 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0046 0.0075
Schistosoma mansoni zinc finger protein 0.0018 0.0018 0.0072
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.002 0.008
Trypanosoma brucei polo-like protein kinase 0.0113 0.0322 0.7172
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0006 0.0026
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0099 0.0278
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0322 0.1139
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0187 0.0156
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.002 0.008
Echinococcus multilocularis zinc finger protein 0.0025 0.004 0.0131
Schistosoma mansoni phd/f-box containing protein 0.0018 0.002 0.0078
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0025 0.0098
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0094 0.0075
Echinococcus granulosus lamin dm0 0.0063 0.0161 0.0642
Schistosoma mansoni cpg binding protein 0.0033 0.0067 0.0268
Brugia malayi cytoplasmic intermediate filament protein 0.0034 0.0068 0.0284
Onchocerca volvulus 0.004 0.0087 0.0162
Loa Loa (eye worm) hypothetical protein 0.0083 0.0224 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0442 1
Schistosoma mansoni bromodomain containing protein 0.0076 0.0203 0.0806
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0222
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0094 0.0262
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0199 0.0791
Loa Loa (eye worm) inositol-1 0.0043 0.0099 0.0416
Schistosoma mansoni cathepsin F (C01 family) 0.004 0.0087 0.0348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0362 0.1442
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0222
Brugia malayi Cathepsin L-like precursor 0.004 0.0087 0.0368
Schistosoma mansoni hypothetical protein 0.0024 0.0038 0.0151
Echinococcus granulosus intermediate filament protein 0.0063 0.0161 0.0642
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0106 0.0299 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0106 0.0299 0.0977
Plasmodium falciparum cysteine proteinase falcipain 1 0.002 0.0026 0.0991
Brugia malayi Intermediate filament tail domain containing protein 0.0063 0.0161 0.0688
Onchocerca volvulus 0.004 0.0087 0.0162
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.002 0.0078
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0031 0.0124
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0735 0.2301 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0126 0.0362 0.1184
Trypanosoma cruzi cruzipain precursor, putative 0.0151 0.0442 1
Onchocerca volvulus 0.004 0.0087 0.0162
Brugia malayi hypothetical protein 0.0285 0.0869 0.3769
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.014 0.0437
Brugia malayi Bromodomain containing protein 0.0089 0.0246 0.1057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Schistosoma mansoni lamin 0.0063 0.0161 0.0642
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0051 0.0204
Brugia malayi Pre-SET motif family protein 0.0106 0.0299 0.1287
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0187 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0442 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.002 0.0078
Loa Loa (eye worm) hypothetical protein 0.0027 0.0046 0.0186
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.014 0.0437
Echinococcus multilocularis cathepsin L cysteine protease 0.004 0.0087 0.0286
Schistosoma mansoni zinc finger protein 0.0025 0.004 0.016
Echinococcus multilocularis lamin dm0 0.0063 0.0161 0.0527
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0094 0.208
Schistosoma mansoni ap endonuclease 0.0022 0.0031 0.0124
Loa Loa (eye worm) hypothetical protein 0.0042 0.0094 0.0397
Echinococcus multilocularis cysteine protease 0.004 0.0087 0.0286
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0094 0.0376
Onchocerca volvulus 0.004 0.0087 0.0162
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.018 0.0716
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.002 0.0072
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0101 0.0284 0.1132
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0094 0.0262
Echinococcus multilocularis cysteine protease 0.004 0.0087 0.0286
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0026 0.0101
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0094 0.0075
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.0238
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0099 0.1896
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0094 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0087 0.0236
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0026 0.0105
Brugia malayi PHD-finger family protein 0.0031 0.006 0.0248
Schistosoma mansoni hypothetical protein 0.0198 0.0591 0.2353
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0087 0.2068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0113 0.0322 0.1389
Loa Loa (eye worm) cysteine protease 0.004 0.0087 0.0368
Echinococcus multilocularis geminin 0.0198 0.0591 0.1931
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.0087 0.1924
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.0322 0.727
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0072
Loa Loa (eye worm) hypothetical protein 0.0048 0.0113 0.0477
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0099 0.0392
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0106 0.0299 0.119
Echinococcus multilocularis cathepsin l cysteine peptidase 0.004 0.0087 0.0286
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0094 0.0075
Echinococcus granulosus neuropeptide s receptor 0.054 0.168 0.6688
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0099 0.0322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0087 0.0236
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0031 0.0952
Echinococcus granulosus cysteine protease 0.002 0.0026 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0322 0.1139
Toxoplasma gondii ABC1 family protein 0.0042 0.0094 0.2677
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0087 0.0236
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0099 0.1896
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.004 0.0087 0.0236
Echinococcus multilocularis cathepsin l cysteine peptidase 0.004 0.0087 0.0286
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0193 0.0768
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.002 0.0072
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0099 0.0278
Trichomonas vaginalis esterase, putative 0.0042 0.0094 0.0262
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.002 0.0034
Plasmodium falciparum cysteine proteinase falcipain 3 0.004 0.0087 1
Leishmania major cathepsin L-like protease 0.0151 0.0442 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0099 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0046 0.0658
Loa Loa (eye worm) ctsf protein 0.004 0.0087 0.0368
Leishmania major cathepsin L-like protease 0.0151 0.0442 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0113 0.0322 0.1072
Trypanosoma cruzi ISWI complex protein 0.0018 0.0018 0.0345
Echinococcus granulosus histone lysine methyltransferase setb 0.0126 0.0362 0.1442
Brugia malayi Cathepsin L-like precursor 0.004 0.0087 0.0368
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0099 0.0278
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.002 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0442 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.002 0.0574
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0026 0.053
Brugia malayi intermediate filament protein 0.0063 0.0161 0.0688
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0031 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0322 0.1139
Brugia malayi Inositol-1 0.0043 0.0099 0.0416
Onchocerca volvulus 0.004 0.0087 0.0162
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.002 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.013 0.0519
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0031 0.0307
Plasmodium vivax vivapain-3 0.002 0.0026 0.0787
Schistosoma mansoni microtubule-associated protein tau 0.0801 0.2512 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.013 0.0554
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.002 0.0377
Trichomonas vaginalis set domain proteins, putative 0.0837 0.2624 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0058 0.0189
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0025 0.0081
Leishmania major cathepsin L-like protease 0.004 0.0087 0.1636
Leishmania major cathepsin L-like protease 0.004 0.0087 0.1636
Mycobacterium ulcerans transcriptional regulator 0.3155 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0031 0.0019
Echinococcus multilocularis cathepsin L 0.002 0.0026 0.0086
Toxoplasma gondii cathepsin CPL 0.004 0.0087 0.2431
Onchocerca volvulus 0.0042 0.0094 0.0188
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0099 0.2827
Trypanosoma cruzi ISWI complex protein 0.0018 0.0018 0.0345
Brugia malayi Cathepsin L-like cysteine proteinase 0.0027 0.0046 0.0186
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0027 0.0104
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0046 0.0182
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0026 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0442 1
Echinococcus granulosus cathepsin l1 0.0027 0.0046 0.0182
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0322 0.1139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0026 0.0192
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0087 0.0368
Brugia malayi jmjC domain containing protein 0.0018 0.002 0.0072
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0187 0.3981
Echinococcus granulosus dnaJ subfamily B 0.0475 0.1473 0.5864
Brugia malayi CXXC zinc finger family protein 0.0033 0.0067 0.028
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0094 0.3087
Onchocerca volvulus Huntingtin homolog 0.0285 0.0869 0.3194
Echinococcus granulosus cathepsin l cysteine peptidase 0.004 0.0087 0.0348
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.018 0.0588
Schistosoma mansoni lamin 0.0063 0.0161 0.0642
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0113 0.0322 0.7172
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0267 0.0811 0.0793
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0439
Loa Loa (eye worm) hypothetical protein 0.0042 0.0094 0.0397
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0094 0.0075

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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