Detailed information for compound 1156991

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 575.57 | Formula: C30H30F5N3O3
  • H donors: 1 H acceptors: 3 LogP: 6.13 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1ccc(c(c1)F)[C@]([C@H](C[C@@H]1CO[C@H](OC1)/C=C/C=C/C=C/c1ccc(cc1)C(F)(F)F)C)(Cn1cncn1)O
  • InChi: 1S/C30H30F5N3O3/c1-21(29(39,18-38-20-36-19-37-38)26-13-12-25(31)15-27(26)32)14-23-16-40-28(41-17-23)7-5-3-2-4-6-22-8-10-24(11-9-22)30(33,34)35/h2-13,15,19-21,23,28,39H,14,16-18H2,1H3/b3-2+,6-4+,7-5+/t21-,23-,28-,29+/m0/s1
  • InChiKey: RAYVTBQCCOPLFE-MFJHGZDJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis esterase, putative 0.0036 0.0322 0.0629
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0089 0.1107 0.257
Onchocerca volvulus 0.0048 0.0495 0.0893
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.4114 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.036 0.0813
Echinococcus multilocularis peregrin 0.0032 0.0255 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.036 0.0813
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.016 0.0138
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0527 0.1341
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0593 0.0578
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0322 0.03
Giardia lamblia Cathepsin B precursor 0.0089 0.1107 0.257
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0293 0.072
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0067 0.0119
Plasmodium vivax hypothetical protein, conserved 0.0029 0.022 0.6825
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.036 0.0338
Echinococcus granulosus dna polymerase eta 0.0064 0.0737 0.0716
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1904 0.4452
Loa Loa (eye worm) hypothetical protein 0.0066 0.0761 0.1963
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.022 0.0198
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.4114 1
Brugia malayi jmjC domain containing protein 0.0025 0.016 0.0367
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.2627 0.261
Brugia malayi Pre-SET motif family protein 0.0209 0.2869 0.7567
Plasmodium vivax JmjC domain containing protein 0.0025 0.016 0.4943
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0271 0.3784 0.3774
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0766 0.1976
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0322 0.0629
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0766 0.1769
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.4114 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.036 0.0813
Plasmodium vivax SET domain protein, putative 0.003 0.0231 0.7148
Schistosoma mansoni jumonji domain containing protein 0.0135 0.1782 0.1769
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.036 0.0813
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.1014 0.0994
Loa Loa (eye worm) hypothetical protein 0.0036 0.0322 0.0796
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.016 0.0138
Loa Loa (eye worm) hypothetical protein 0.0047 0.0483 0.1225
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0183 0.0395
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0593 0.0571
Echinococcus granulosus expressed protein 0.0033 0.0283 0.0261
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.016 0.0138
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.036 0.0724
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0593 0.0571
Loa Loa (eye worm) RecQ helicase 0.0021 0.0105 0.0219
Loa Loa (eye worm) hypothetical protein 0.0083 0.1014 0.2637
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0321 0.0299
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0322 0.0307
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.036 0.0898
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.121 0.119
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0272 0.0604
Schistosoma mansoni hypothetical protein 0.0083 0.1014 0.1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0766 0.0745
Mycobacterium tuberculosis Conserved protein 0.0036 0.0322 0.0943
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0322 0.1226
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.4114 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0322 0.0796
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.016 0.0145
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0089 0.1107 0.2574
Brugia malayi Pre-SET motif family protein 0.003 0.0231 0.0554
Loa Loa (eye worm) hypothetical protein 0.0034 0.0293 0.072
Loa Loa (eye worm) hypothetical protein 0.0041 0.0392 0.0982
Loa Loa (eye worm) MBCTL1 0.0054 0.0593 0.1516
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.1014 0.1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0105 0.0093
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.4258 1
Brugia malayi jmjC domain containing protein 0.0025 0.016 0.0367
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0007
Echinococcus granulosus zinc finger protein 0.002 0.0079 0.0056
Echinococcus multilocularis lysine specific demethylase 5A 0.0094 0.1181 0.1162
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0067 0.0045
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0737 0.1701
Schistosoma mansoni ap endonuclease 0.0019 0.0067 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0322 0.0722
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.036 0.0724
Brugia malayi cathepsin B-like cysteine proteinase 0.0271 0.3784 1
Leishmania major DNA polymerase kappa, putative 0.0039 0.036 0.0813
Schistosoma mansoni hypothetical protein 0.0295 0.4136 0.4127
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0322 0.0943
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.036 0.0813
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.1107 0.1094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0483 0.0468
Echinococcus multilocularis cathepsin b 0.0271 0.3784 0.377
Trichomonas vaginalis rotamase, putative 0.0033 0.0272 0.0505
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0389 0.0368
Trypanosoma brucei cysteine peptidase C (CPC) 0.0089 0.1107 0.2574
Brugia malayi jmjC domain containing protein 0.0025 0.016 0.0367
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0495 0.0473
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0067 0.0045
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0322 0.0943
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0067 0.0122
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0272 0.0604
Onchocerca volvulus 0.0036 0.0322 0.033
Echinococcus multilocularis dna polymerase kappa 0.0039 0.036 0.0338
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.4114 1
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.036 0.1411
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0322 0.03
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0089 0.1107 0.2574
Schistosoma mansoni hypothetical protein 0.0034 0.0293 0.0278
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0067 0.0119
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.016 0.0367
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0067 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0183 0.0395
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.036 0.0813
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.4114 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0417 0.0948
Schistosoma mansoni bromodomain containing protein 0.0063 0.0725 0.0711
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.016 0.0138
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.036 0.1411
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.036 0.0813
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0067 0.0122
Leishmania major DNA polymerase eta, putative 0.0064 0.0737 0.1701
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0023 0.0017
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0214 0.0192
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0322 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0322 0.0722
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0483 0.0462
Brugia malayi mbt repeat family protein 0.0048 0.0495 0.1256
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.016 0.0342
Leishmania major hypothetical protein, conserved 0.0036 0.0322 0.0722
Leishmania major DNA polymerase eta, putative 0.0038 0.0343 0.0773
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0155 0.2072 0.2054
Loa Loa (eye worm) hypothetical protein 0.005 0.0527 0.1341
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.022 0.1991
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0322 0.0629
Loa Loa (eye worm) hypothetical protein 0.0054 0.0593 0.1516
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.1014 0.0994
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.4114 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.3193 1
Brugia malayi jmjC domain containing protein 0.0096 0.121 0.3157
Brugia malayi beta-lactamase family protein 0.0036 0.0322 0.0796
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0023 0.0017
Brugia malayi mbt repeat family protein 0.0048 0.0495 0.1256
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0495 0.0473
Leishmania major hypothetical protein, conserved 0.0025 0.016 0.0342
Brugia malayi Bromodomain containing protein 0.0075 0.0899 0.233
Loa Loa (eye worm) hypothetical protein 0.0036 0.0322 0.0796
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0023 0.0001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0672 0.0651
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0272 0.0604
Loa Loa (eye worm) hypothetical protein 0.0025 0.016 0.0367
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.1014 0.2637
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0283 0.0693
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0049
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0343 0.0773
Echinococcus granulosus cathepsin b 0.0271 0.3784 0.377
Loa Loa (eye worm) hypothetical protein 0.0029 0.022 0.0526
Loa Loa (eye worm) hypothetical protein 0.0025 0.016 0.0367
Giardia lamblia PHD finger protein 15 0.0029 0.022 0.0378
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0023 0.0635
Toxoplasma gondii ABC1 family protein 0.0036 0.0322 0.2906
Loa Loa (eye worm) beta-lactamase 0.0036 0.0322 0.0796
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0737 0.1701
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.2143 0.6688
Onchocerca volvulus 0.003 0.0231 0.0034
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0322 0.0796
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.121 0.1196
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0155 0.2072 0.2054
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1904 0.4452
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.1014 0.2637
Schistosoma mansoni DNA polymerase eta 0.0064 0.0737 0.0723
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0672 0.0651
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.1014 0.0994
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0322 0.0943
Giardia lamblia Cathepsin B precursor 0.0089 0.1107 0.257
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0189 0.0167
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.4114 1
Onchocerca volvulus 0.0036 0.0322 0.033
Echinococcus granulosus dna polymerase kappa 0.0039 0.036 0.0338
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.036 0.0338
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0495 0.1256
Toxoplasma gondii exonuclease III APE 0.0019 0.0067 0.0608
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0322 0.0629
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.016 0.696
Echinococcus granulosus cathepsin b 0.0271 0.3784 0.377
Brugia malayi beta-lactamase family protein 0.0036 0.0322 0.0796
Loa Loa (eye worm) cathepsin B 0.0089 0.1107 0.2884
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0766 0.1976
Echinococcus multilocularis microtubule associated protein 2 0.0692 1 1
Schistosoma mansoni ap endonuclease 0.0019 0.0067 0.0052
Brugia malayi PHD-finger family protein 0.0025 0.0158 0.0359
Schistosoma mansoni microtubule-associated protein tau 0.0692 1 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0766 0.0752
Schistosoma mansoni hypothetical protein 0.0083 0.1014 0.1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0322 0.0307
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0354 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.036 0.0813
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0283 0.0534
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.036 0.0813
Giardia lamblia DINP protein human, muc B family 0.0039 0.036 0.0724
Trypanosoma brucei unspecified product 0.0027 0.0183 0.0395
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0272 0.0604
Echinococcus multilocularis phd:f box containing protein 0.0025 0.016 0.0138
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0483 0.0462
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.036 0.0813
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0231 0.0209
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0417 0.0948
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0067 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0322 0.0796
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.036 0.0345
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0231 0.0216
Brugia malayi isocitrate dehydrogenase 0.0016 0.0023 0.0001
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.016 0.0145
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0007
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0041 0.0019
Schistosoma mansoni hypothetical protein 0.0021 0.0094 0.0079
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0271 0.3784 0.8882
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.121 0.3157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0527 0.1341
Brugia malayi jmjC domain containing protein 0.0155 0.2072 0.545
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0272 0.2453
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0271 0.3784 0.3774
Loa Loa (eye worm) hypothetical protein 0.0048 0.0495 0.1256
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.022 0.1991
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.4114 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0766 0.1769
Schistosoma mansoni hypothetical protein 0.0083 0.1014 0.1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0321 0.0299
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0067 0.0122
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0023 0.0007
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0766 0.1726
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0023 0.0017
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.036 0.1064
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0389 0.0368
Mycobacterium ulcerans beta-lactamase 0.0036 0.0322 0.1226
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0322 0.0943
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.022 0.0526
Loa Loa (eye worm) hypothetical protein 0.0038 0.0357 0.0889
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.036 0.0898
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0495 0.048
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0094 0.0191
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.016 0.0367
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.036 0.0813
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.036 0.0813
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0483 0.0468
Mycobacterium tuberculosis Conserved protein 0.0036 0.0322 0.0943
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0527 0.1341
Loa Loa (eye worm) hypothetical protein 0.0071 0.0835 0.2162
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.4114 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0041 0.0026
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0417 0.0948
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0123 0.01
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.036 0.0813
Mycobacterium tuberculosis Conserved protein 0.0036 0.0322 0.0943
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0183 0.0395
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0189 0.0167
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.1902 0.5927
Schistosoma mansoni phd/f-box containing protein 0.0025 0.016 0.0145
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.016 0.0342
Echinococcus granulosus peregrin 0.0032 0.0255 0.0234
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1904 0.4452
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0417 0.0948
Echinococcus granulosus bloom syndrome protein 0.0021 0.0105 0.0083
Schistosoma mansoni jumonji domain containing protein 0.0025 0.016 0.0145
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0593 0.0571
Schistosoma mansoni apoptosis regulator bax 0.0083 0.1014 0.1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0555 0.1272
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0322 0.0943
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0283 0.0693
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0322 0.0629
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.016 0.1448
Brugia malayi PHD-finger family protein 0.0029 0.022 0.0526
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0231 0.0216
Mycobacterium ulcerans lipase LipD 0.0036 0.0322 0.1226
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2869 0.7567
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0272 0.0505
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0105 0.0219
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.068 0.1748
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0067 0.2029
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0067 0.0122
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.036 0.0813
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0067 0.2252
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0041 0.0019
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0007
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.4258 1
Onchocerca volvulus 0.0036 0.0322 0.033
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0322 0.1226
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0023 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.036 0.0813
Schistosoma mansoni rotamase 0.0033 0.0283 0.0268
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0038 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0322 0.0629
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.4114 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.121 0.1196
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0495 0.048
Echinococcus granulosus phd:f box containing protein 0.0025 0.016 0.0138
Brugia malayi beta-lactamase 0.0036 0.0322 0.0796
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0023 0.0206
Toxoplasma gondii cathepsin B 0.0089 0.1107 1
Brugia malayi jmjC domain containing protein 0.0025 0.016 0.0367
Trypanosoma brucei unspecified product 0.0039 0.036 0.0813
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0322 0.0943
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.1014 0.0994
Trichomonas vaginalis set domain proteins, putative 0.0238 0.3294 0.7974
Schistosoma mansoni hypothetical protein 0.0029 0.022 0.0205
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0766 0.1769
Schistosoma mansoni zinc finger protein 0.002 0.0079 0.0063
Echinococcus multilocularis expressed protein 0.0033 0.0283 0.0261
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0041 0.0026
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.016 0.0342
Trichomonas vaginalis rotamase, putative 0.0033 0.0283 0.0534
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0066 0.2207
Onchocerca volvulus 0.0238 0.3294 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0271 0.3784 0.3774
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0495 0.0473
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0023 0.0017
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.016 0.1448
Loa Loa (eye worm) hypothetical protein 0.0036 0.0322 0.0796
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.005 0.0074
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.016 0.0138
Echinococcus multilocularis dna polymerase eta 0.0064 0.0737 0.0716
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0007
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.036 0.0724
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0495 0.0893
Loa Loa (eye worm) hypothetical protein 0.0036 0.0322 0.0796
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0123 0.0107
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0105 0.0083
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0495 0.0473
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.036 0.1064
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0766 0.1769
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0343 0.31
Brugia malayi Bromodomain containing protein 0.0038 0.0356 0.0886
Giardia lamblia Cathepsin B precursor 0.0089 0.1107 0.257
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.1902 0.8838
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.022 0.0198
Loa Loa (eye worm) hypothetical protein 0.0064 0.0737 0.19
Echinococcus multilocularis zinc finger protein 0.002 0.0079 0.0056
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.016 0.0367
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.036 0.0345
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.022 0.0205
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0023 0.0206
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.2627 0.261
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.036 0.0813
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.036 0.0813
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0766 0.0745
Brugia malayi Bromodomain containing protein 0.0032 0.0255 0.062
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.016 0.0138
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0593 0.1516
Loa Loa (eye worm) hypothetical protein 0.0036 0.0322 0.0796
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0271 0.3784 0.3774
Mycobacterium ulcerans hypothetical protein 0.0036 0.0322 0.1226
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.036 0.0813
Trypanosoma brucei unspecified product 0.0027 0.0183 0.0395
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0322 0.0943
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0322 0.0722
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0495 0.048
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0023 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.4114 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0105 0.0093
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0593 0.0571
Loa Loa (eye worm) hypothetical protein 0.0271 0.3784 1
Schistosoma mansoni protein phosphatase 2C 0.0025 0.016 0.0145
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0354 0.0333
Toxoplasma gondii hypothetical protein 0.0049 0.051 0.4604
Mycobacterium ulcerans hypothetical protein 0.016 0.2143 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.022 1
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0737 0.19
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.1902 1
Echinococcus multilocularis cathepsin b 0.0271 0.3784 0.377
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.4258 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0123 0.01
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0231 0.2084
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.4258 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.042 0.1057

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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