Detailed information for compound 115929

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 322.85 | Formula: C18H25ClNO2-
  • H donors: 0 H acceptors: 1 LogP: 4.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCC1(C)OC=C(C1=O)c1ccccc1)CC.[Cl-]
  • InChi: 1S/C18H25NO2.ClH/c1-4-19(5-2)13-9-12-18(3)17(20)16(14-21-18)15-10-7-6-8-11-15;/h6-8,10-11,14H,4-5,9,12-13H2,1-3H3;1H/p-1
  • InChiKey: QVDIWIVCIHYJNK-UHFFFAOYSA-M  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0573 0.289 0.289
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0244 0.1169 0.1322
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0002 0.0002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0291 0.1416 0.1601
Loa Loa (eye worm) hypothetical protein 0.0277 0.1344 0.152
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0049 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0244 0.1169 0.1322
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0559
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0241 0.1157 0.1016
Entamoeba histolytica hexokinase 1 0.1712 0.8844 1
Brugia malayi Hexokinase family protein 0.1712 0.8844 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0241 0.1157 0.1308
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0022 0.0024
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0028 0.0042 0.0047
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0614 0.3106 0.3512
Brugia malayi Cyclic-nucleotide gated cation channel 0.002 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0277 0.1344 0.152
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0047 0.0054
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.014 0.014
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0047 0.0054
Echinococcus granulosus histone lysine methyltransferase setb 0.0244 0.1169 0.1322
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0293 0.1426 0.1612
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0042 0.0047
Brugia malayi Hexokinase family protein 0.1074 0.5509 0.623
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0287 0.0293
Echinococcus multilocularis Smad4 0.0068 0.0252 0.0285
Trypanosoma cruzi DNA damage repair protein, putative 0.0075 0.0287 0.0325
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0117 0.0133
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0241 0.1157 0.1279
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0024 0.0022 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.014 0.014
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0047 0.0021
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0339
Leishmania major DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0042 0.0047
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0042 0.0047
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0197 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0241 0.1157 0.1308
Trypanosoma brucei DNA polymerase IV, putative 0.0241 0.1157 0.1279
Echinococcus granulosus dna polymerase kappa 0.0241 0.1157 0.1308
Loa Loa (eye worm) hypothetical protein 0.0241 0.1157 0.1308
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0049 0.0023
Echinococcus granulosus lysine specific demethylase 5A 0.0109 0.0464 0.0524
Loa Loa (eye worm) hypothetical protein 0.0598 0.3024 0.342
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0277 0.1344 0.152
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0117 0.0133
Schistosoma mansoni hypothetical protein 0.0598 0.3024 0.342
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0068 0.0252 0.0285
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0277 0.1344 0.152
Echinococcus granulosus peregrin 0.0097 0.0403 0.0456
Trichomonas vaginalis penicillin-binding protein, putative 0.0293 0.1426 0.1426
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0105
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0047 0.0054
Schistosoma mansoni DNA polymerase IV / kappa 0.0075 0.0287 0.0325
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0068 0.0251 0.0284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0387 0.0437
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0287 0.0325
Giardia lamblia DINP protein human, muc B family 0.0241 0.1157 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0049 0.0023
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0028 0.0042 0.0047
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0057 0.0192 0.0217
Brugia malayi DIX domain containing protein 0.0028 0.0042 0.0047
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.0287 0.0325
Brugia malayi RNA binding protein 0.0071 0.0267 0.0302
Onchocerca volvulus 0.1712 0.8844 0.8844
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0047 0.0054
Trypanosoma brucei hexokinase, putative 0.1712 0.8844 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0293 0.1426 0.1426
Trypanosoma brucei unspecified product 0.0166 0.0765 0.0835
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0267 0.0302
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0251 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0166 0.0765 0.0835
Loa Loa (eye worm) MH1 domain-containing protein 0.0068 0.0252 0.0285
Echinococcus granulosus mothers against decapentaplegic 6 0.003 0.0055 0.0062
Mycobacterium ulcerans lipase LipD 0.0293 0.1426 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0047
Brugia malayi MH2 domain containing protein 0.0999 0.512 0.579
Trypanosoma cruzi hypothetical protein, conserved 0.0293 0.1426 0.1612
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0194 0.022
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0356 0.0371
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0068 0.0252 0.0285
Onchocerca volvulus 0.0244 0.1169 0.1169
Mycobacterium ulcerans hypothetical protein 0.0293 0.1426 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.009 0.0365 0.0413
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0267 0.0302
Brugia malayi Importin beta-1 subunit 0.0058 0.0197 0.0222
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.222 0.2511
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0287 0.0293
Trypanosoma brucei DNA polymerase kappa, putative 0.0166 0.0765 0.0835
Brugia malayi latrophilin 2 splice variant baaae 0.0598 0.3024 0.342
Brugia malayi hypothetical protein 0.0028 0.0042 0.0047
Trichomonas vaginalis beta-galactosidase, putative 0.0504 0.2529 0.2529
Schistosoma mansoni hexokinase 0.1712 0.8844 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.01 0.0113
Leishmania major hexokinase, putative 0.1712 0.8844 1
Echinococcus granulosus hexokinase 0.1712 0.8844 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0277 0.1344 0.152
Mycobacterium leprae Probable lipase LipE 0.0293 0.1426 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0068 0.0251 0.0284
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.002 0.0002 0.0002
Onchocerca volvulus 0.0028 0.0042 0.0042
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0053 0.0173 0.0195
Echinococcus granulosus PHD finger protein rhinoceros 0.009 0.0365 0.0413
Loa Loa (eye worm) hexokinase 0.053 0.2665 0.3013
Plasmodium falciparum importin beta, putative 0.0058 0.0197 0.019
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0068 0.0251 0.0252
Trypanosoma cruzi DNA polymerase eta, putative 0.0241 0.1157 0.1308
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.01 0.0113
Echinococcus multilocularis lysine specific demethylase 5A 0.0109 0.0464 0.0524
Loa Loa (eye worm) acetyltransferase 0.0299 0.146 0.1651
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0875 0.4472 0.5057
Schistosoma mansoni hypothetical protein 0.009 0.0365 0.0413
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0002 0.0002
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0002 0.0002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0293 0.1426 0.13
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Trichomonas vaginalis esterase, putative 0.0293 0.1426 0.1426
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0055 0.0062
Loa Loa (eye worm) hypothetical protein 0.0573 0.289 0.3268
Plasmodium vivax SET domain protein, putative 0.0244 0.1169 0.1294
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1641 0.8472 0.958
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0002 0.0002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0068 0.0251 0.0284
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0049 0.0023
Schistosoma mansoni dishevelled 0.0028 0.0042 0.0047
Schistosoma mansoni smad1 5 8 and 0.0068 0.0252 0.0285
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0002 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0293 0.1426 0.1612
Echinococcus granulosus GPCR family 2 0.0277 0.1344 0.152
Brugia malayi Pre-SET motif family protein 0.0244 0.1169 0.1322
Plasmodium vivax hexokinase, putative 0.1712 0.8844 1
Brugia malayi manba-prov protein 0.0163 0.075 0.0848
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0002 0.0002
Trichomonas vaginalis beta-mannosidase, putative 0.0163 0.075 0.075
Plasmodium vivax hypothetical protein, conserved 0.0293 0.1426 0.1584
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0055 0.0062
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0293 0.1426 0.1612
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0277 0.1344 0.152
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.0022 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0387 0.0437
Trypanosoma cruzi hypothetical protein, conserved 0.0293 0.1426 0.1612
Brugia malayi isocitrate dehydrogenase 0.0068 0.0251 0.0284
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0194 0.103
Leishmania major hexokinase, putative 0.1712 0.8844 1
Schistosoma mansoni hypothetical protein 0.0041 0.011 0.0125
Leishmania major DNA polymerase kappa, putative 0.0075 0.0287 0.0293
Trichomonas vaginalis D-aminoacylase, putative 0.0293 0.1426 0.1426
Mycobacterium tuberculosis Conserved protein 0.0293 0.1426 0.13
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0267 0.0302
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0055 0.0062
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0299 0.146 0.1651
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0293 0.1426 0.1612
Loa Loa (eye worm) hypothetical protein 0.009 0.0365 0.0413
Trypanosoma brucei hexokinase 0.1712 0.8844 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0002 0.0002
Echinococcus granulosus Pleckstrin G protein interacting region 0.0028 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0544 0.2741 0.3099
Schistosoma mansoni smad1 5 8 and 0.0068 0.0252 0.0285
Trichomonas vaginalis importin beta-1, putative 0.0047 0.014 0.014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0251 0.0284
Echinococcus granulosus importin subunit beta 1 0.0058 0.0197 0.0222
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0387 0.0437
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0299 0.146 0.1651
Entamoeba histolytica Ran family GTPase 0.0042 0.0117 0.0133
Leishmania major GTP-binding protein, putative 0.0042 0.0117 0.01
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.009 0.0365 0.0413
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.005 0.0159 0.0159
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.222 0.2486
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0047 0.0054
Loa Loa (eye worm) Smad1 0.0068 0.0252 0.0285
Trypanosoma cruzi DNA polymerase kappa, putative 0.0241 0.1157 0.1308
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0251 0.0252
Loa Loa (eye worm) beta-lactamase 0.0293 0.1426 0.1612
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Loa Loa (eye worm) hexokinase 0.1074 0.5509 0.623
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0241 0.1157 0.1308
Echinococcus granulosus mothers against decapentaplegic 2 0.003 0.0055 0.0062
Trichomonas vaginalis ran, putative 0.0042 0.0117 0.0117
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0068 0.0251 0.0252
Loa Loa (eye worm) hexokinase type II 0.1712 0.8844 1
Mycobacterium ulcerans DNA polymerase IV 0.0241 0.1157 0.7639
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0241 0.1157 0.1308
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0047 0.0054
Brugia malayi beta-lactamase family protein 0.0293 0.1426 0.1612
Echinococcus granulosus voltage gated potassium channel 0.0024 0.0022 0.0024
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0227 0.1084 0.1226
Trypanosoma brucei DNA polymerase IV, putative 0.0241 0.1157 0.1279
Echinococcus granulosus hexokinase 0.1712 0.8844 1
Mycobacterium ulcerans DNA polymerase IV 0.0241 0.1157 0.7639
Echinococcus granulosus smad 0.0068 0.0252 0.0285
Echinococcus multilocularis geminin 0.1264 0.6503 0.7354
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.0365 0.0381
Loa Loa (eye worm) MH2 domain-containing protein 0.0068 0.0252 0.0285
Loa Loa (eye worm) hypothetical protein 0.0544 0.2741 0.3099
Trypanosoma cruzi DNA damage repair protein, putative 0.0075 0.0287 0.0325
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0241 0.1157 0.1308
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0277 0.1344 0.152
Brugia malayi MH2 domain containing protein 0.0068 0.0252 0.0285
Schistosoma mansoni voltage-gated potassium channel 0.0057 0.0192 0.0217
Trypanosoma brucei DNA damage repair protein, putative 0.0075 0.0287 0.0293
Giardia lamblia Histone acetyltransferase GCN5 0.0081 0.0318 0.1927
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0053 0.0173 0.0195
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0244 0.1169 0.1322
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0047 0.0021
Trypanosoma brucei DNA damage repair protein, putative 0.0075 0.0287 0.0293
Echinococcus granulosus tar DNA binding protein 0.0071 0.0267 0.0302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0387 0.0437
Schistosoma mansoni hypothetical protein 0.0277 0.1344 0.152
Loa Loa (eye worm) hypothetical protein 0.0875 0.4472 0.5057
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0022 0.0024
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.002 0.0002 0.0002
Mycobacterium ulcerans beta-lactamase 0.0293 0.1426 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0397
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0351 0.0365
Leishmania major DNA polymerase eta, putative 0.0075 0.0287 0.0293
Leishmania major DNA polymerase eta, putative 0.0241 0.1157 0.1279
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0235 0.1122 0.1269
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0251 0.0284
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0177 0.0821 0.0928
Loa Loa (eye worm) transcription factor SMAD2 0.0999 0.512 0.579
Brugia malayi MH1 domain containing protein 0.0068 0.0252 0.0285
Toxoplasma gondii hypothetical protein 0.0028 0.0042 0.0015
Brugia malayi hypothetical protein 0.0039 0.01 0.0113
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0047 0.0054
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0351 0.0365
Schistosoma mansoni beta-mannosidase 0.0163 0.075 0.0848
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.005 0.0159 0.0159
Onchocerca volvulus Alhambra homolog 0.009 0.0365 0.0365
Schistosoma mansoni dep domain containing protein 0.0028 0.0042 0.0047
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0117 0.0133
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0047
Brugia malayi MH1 domain containing protein 0.0038 0.0093 0.0105
Echinococcus multilocularis dna polymerase eta 0.0241 0.1157 0.1308
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0356 0.0402
Trypanosoma brucei hexokinase 0.1712 0.8844 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0068 0.0251 0.006
Loa Loa (eye worm) RNA binding protein 0.0071 0.0267 0.0302
Echinococcus granulosus dna polymerase eta 0.0241 0.1157 0.1308
Loa Loa (eye worm) jmjC domain-containing protein 0.0185 0.0865 0.0978
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0002 0.0002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0293 0.1426 0.13
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.2529 0.2529
Trichomonas vaginalis D-aminoacylase, putative 0.0293 0.1426 0.1426
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0002 0.0002
Brugia malayi TAR-binding protein 0.0071 0.0267 0.0302
Schistosoma mansoni smad 0.003 0.0055 0.0062
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.5
Brugia malayi Smad1 0.0068 0.0252 0.0285
Brugia malayi jmjC domain containing protein 0.0029 0.0047 0.0054
Mycobacterium ulcerans esterase/lipase LipP 0.0293 0.1426 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0053 0.0027
Echinococcus multilocularis GPCR, family 2 0.0277 0.1344 0.152
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0351 0.0365
Brugia malayi regulator of G-protein signaling egl-10 0.0028 0.0042 0.0047
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0113
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0047 0.0054
Mycobacterium tuberculosis Probable esterase LipL 0.0293 0.1426 0.13
Echinococcus multilocularis beta LACTamase domain containing family member 0.0293 0.1426 0.1612
Schistosoma mansoni hypothetical protein 0.1264 0.6503 0.7354
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0029 0.0047 0.0054
Trypanosoma brucei unspecified product 0.0241 0.1157 0.1279
Loa Loa (eye worm) latrophilin receptor protein 2 0.0277 0.1344 0.152
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0029 0.0033
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0053 0.0173 0.0195
Loa Loa (eye worm) hypothetical protein 0.0154 0.07 0.0792
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.002 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.0029 0.0047 0.0021
Loa Loa (eye worm) nuclear factor I 0.0038 0.0093 0.0105
Mycobacterium tuberculosis Probable lipase LipE 0.0293 0.1426 0.13
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Schistosoma mansoni z-protein (S1r protein) 0.0028 0.0042 0.0047
Mycobacterium tuberculosis Possible penicillin-binding protein 0.187 0.9669 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0287 0.0293
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0365
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.0351 0.2172
Brugia malayi hexokinase 0.1712 0.8844 1
Brugia malayi jmjC domain containing protein 0.0029 0.0047 0.0054
Brugia malayi F/Y-rich N-terminus family protein 0.0038 0.0096 0.0109
Leishmania major DNA damage repair protein, putative 0.0075 0.0287 0.0293
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0387 0.0437
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0387 0.0437
Loa Loa (eye worm) hypothetical protein 0.0075 0.0287 0.0325
Schistosoma mansoni ran 0.0042 0.0117 0.0133
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0002 0.0002
Brugia malayi RNA, U transporter 1 0.0164 0.0751 0.0849
Onchocerca volvulus 0.1074 0.5509 0.5509
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Echinococcus granulosus snurportin 1 0.0614 0.3106 0.3512
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Echinococcus granulosus TGF beta signal transducer SmadC 0.0068 0.0252 0.0285
Brugia malayi hypothetical protein 0.0025 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0054
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0241 0.1157 0.1157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0241 0.1157 0.1308
Schistosoma mansoni DNA polymerase eta 0.0241 0.1157 0.1308
Onchocerca volvulus 0.0293 0.1426 0.1426
Onchocerca volvulus Hexokinase homolog 0.1074 0.5509 0.5509
Schistosoma mansoni Smad4 0.003 0.0055 0.0062
Echinococcus multilocularis hexokinase 0.1712 0.8844 1
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Loa Loa (eye worm) hexokinase 0.1712 0.8844 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0244 0.1169 0.1294
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0056
Schistosoma mansoni hypothetical protein 0.0039 0.01 0.0113
Schistosoma mansoni ran 0.0042 0.0117 0.0133
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0397
Loa Loa (eye worm) PHD-finger family protein 0.009 0.0365 0.0413
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0028 0.0042 0.0042
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0029 0.0047 0.0054
Schistosoma mansoni jumonji domain containing protein 0.0234 0.1117 0.1263
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0318 0.0327
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0053 0.0173 0.0195
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0042 0.0047
Plasmodium vivax DNA repair protein REV1, putative 0.0075 0.0287 0.0293
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0028 0.0042 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Schistosoma mansoni Smad4 0.003 0.0055 0.0062
Giardia lamblia DNA damage repair protein 0.0075 0.0287 0.1635
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0042 0.0047
Echinococcus granulosus geminin 0.1264 0.6503 0.7354
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0002 0.0002
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0042 0.0047
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0002 0.0002
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0117 0.0133
Loa Loa (eye worm) hypothetical protein 0.0058 0.0197 0.0222
Echinococcus multilocularis mothers against decapentaplegic 2 0.003 0.0055 0.0062
Echinococcus granulosus beta LACTamase domain containing family member 0.0293 0.1426 0.1612
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0047
Echinococcus granulosus Smad4 0.0068 0.0252 0.0285
Loa Loa (eye worm) DIX domain-containing protein 0.0028 0.0042 0.0047
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0251 0.0252
Toxoplasma gondii isocitrate dehydrogenase 0.0068 0.0251 0.0252
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0113
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.0022 0.0024
Echinococcus granulosus hexokinase 0.1712 0.8844 1
Echinococcus multilocularis smad 0.0068 0.0252 0.0285
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0024 0.0023 0.0026
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0197 0.0222
Brugia malayi acetyltransferase, GNAT family protein 0.0299 0.146 0.1651
Schistosoma mansoni smad 0.0068 0.0252 0.0285
Brugia malayi hypothetical protein 0.0028 0.0042 0.0047
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0267 0.0302
Plasmodium vivax importin-beta 2, putative 0.0058 0.0197 0.019
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.0365 0.0381
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Brugia malayi MH1 domain containing protein 0.0038 0.0093 0.0105
Schistosoma mansoni hypothetical protein 0.1264 0.6503 0.7354
Echinococcus multilocularis dna polymerase kappa 0.0241 0.1157 0.1308
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0267 0.0302
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0294 0.1432 0.162
Trichomonas vaginalis D-aminoacylase, putative 0.0293 0.1426 0.1426
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0117 0.01
Toxoplasma gondii hexokinase 0.1712 0.8844 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0029 0.0049 0.0023
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0047 0.0021
Brugia malayi MH2 domain containing protein 0.0068 0.0252 0.0285
Schistosoma mansoni hypothetical protein 0.0277 0.1344 0.152
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0194 0.022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0054
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0068 0.0251 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0244 0.1169 0.1322
Onchocerca volvulus 0.1712 0.8844 0.8844
Loa Loa (eye worm) hypothetical protein 0.1167 0.5999 0.6783
Echinococcus multilocularis hexokinase 0.1712 0.8844 1
Mycobacterium leprae conserved hypothetical protein 0.0293 0.1426 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.5
Echinococcus multilocularis mothers against decapentaplegic 6 0.003 0.0055 0.0062
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0047 0.0054
Onchocerca volvulus 0.0293 0.1426 0.1426
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0356 0.0356
Toxoplasma gondii hypothetical protein 0.003 0.0053 0.0027
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0559
Mycobacterium tuberculosis Probable lipase LipD 0.0293 0.1426 0.13
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0042 0.0047
Brugia malayi beta-lactamase 0.0293 0.1426 0.1612
Brugia malayi MH1 domain containing protein 0.0068 0.0252 0.0285
Loa Loa (eye worm) hexokinase 0.1712 0.8844 1
Toxoplasma gondii ABC1 family protein 0.0293 0.1426 0.1584
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.002 0.0002 0.0002
Brugia malayi ImpB/MucB/SamB family protein 0.0241 0.1157 0.1308
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0075 0.0287 0.0293
Brugia malayi jmjC domain containing protein 0.0029 0.0047 0.0054
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0053 0.0027
Brugia malayi jmjC domain containing protein 0.0109 0.0464 0.0524
Brugia malayi Calcitonin receptor-like protein seb-1 0.0875 0.4472 0.5057
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0042 0.0047
Brugia malayi ImpB/MucB/SamB family protein 0.0241 0.1157 0.1308
Loa Loa (eye worm) jmjC domain-containing protein 0.0109 0.0464 0.0524
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0293 0.1426 0.13
Brugia malayi PHD-finger family protein 0.0029 0.0049 0.0056
Plasmodium falciparum hexokinase 0.1712 0.8844 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0267 0.0302
Plasmodium vivax hypothetical protein, conserved 0.009 0.0365 0.0381
Brugia malayi Isocitrate dehydrogenase 0.0068 0.0251 0.0284
Brugia malayi N-terminal motif family protein 0.0573 0.289 0.3268
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0318 0.0359
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0075 0.0287 0.0293
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Echinococcus multilocularis mothers against decapentaplegic 5 0.0068 0.0252 0.0285
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Trichomonas vaginalis glycoside hydrolase, putative 0.0804 0.4101 0.4101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0244 0.1169 0.1322
Brugia malayi polk-prov protein 0.0075 0.0287 0.0325
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0047 0.0054
Brugia malayi beta-lactamase family protein 0.0293 0.1426 0.1612
Trypanosoma brucei DNA polymerase kappa, putative 0.0166 0.0765 0.0835
Trypanosoma cruzi hexokinase, putative 0.1712 0.8844 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0999 0.512 0.579
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0387 0.0437
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Onchocerca volvulus 0.0293 0.1426 0.1426
Echinococcus multilocularis snurportin 1 0.0614 0.3106 0.3512
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0267 0.0302
Brugia malayi MH2 domain containing protein 0.003 0.0055 0.0062
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0287 0.0293
Mycobacterium tuberculosis Probable hydrolase 0.0293 0.1426 0.13
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0244 0.1169 0.1322
Echinococcus granulosus mothers against decapentaplegic 5 0.0068 0.0252 0.0285
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0042 0.0047
Echinococcus multilocularis peregrin 0.0097 0.0403 0.0456
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0068 0.0251 0.0252
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.222 0.2511
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0197 0.019
Schistosoma mansoni regulator of G protein signaling 0.0028 0.0042 0.0047
Trypanosoma cruzi hexokinase, putative 0.1712 0.8844 1
Entamoeba histolytica hypothetical protein 0.0047 0.014 0.0158
Schistosoma mansoni dishevelled 0.0028 0.0042 0.0047
Trypanosoma brucei chrX additional, unordered contigs 0.0075 0.0287 0.0293
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0047 0.0054
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0117 0.01
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0356 0.0371
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0177 0.0821 0.0928
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0117 0.0133
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.01 0.0113
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0117 0.0133
Brugia malayi Bromodomain containing protein 0.0097 0.0403 0.0456
Schistosoma mansoni Smad4 0.0068 0.0252 0.0285
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.0022 0.0024
Schistosoma mansoni hypothetical protein 0.0029 0.0049 0.0056
Mycobacterium tuberculosis Conserved protein 0.0293 0.1426 0.13
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.5
Entamoeba histolytica beta-galactosidase, putative 0.034 0.1675 0.1894
Echinococcus multilocularis isocitrate dehydrogenase 0.0068 0.0251 0.0284
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0047 0.0054
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.0351 0.0397
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0113
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0387 0.0437
Mycobacterium tuberculosis Conserved protein 0.0293 0.1426 0.13
Entamoeba histolytica hexokinase 2 0.1712 0.8844 1
Giardia lamblia PHD finger protein 15 0.009 0.0365 0.2384
Brugia malayi Probable ClpP-like protease 0.0087 0.0351 0.0397
Schistosoma mansoni importin beta-1 0.0058 0.0197 0.0222
Trypanosoma brucei hypothetical protein, conserved 0.0293 0.1426 0.1584
Loa Loa (eye worm) beta-glucuronidase 0.0163 0.075 0.0848
Loa Loa (eye worm) hypothetical protein 0.0087 0.0351 0.0397
Trypanosoma brucei DNA polymerase eta, putative 0.0241 0.1157 0.1279
Loa Loa (eye worm) hypothetical protein 0.0445 0.222 0.2511
Brugia malayi Pre-SET motif family protein 0.1698 0.8774 0.9921
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0244 0.1169 0.1322
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0096 0.0109
Echinococcus granulosus phd:f box containing protein 0.0029 0.0047 0.0054
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0113
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0117 0.01
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0117 0.01
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0875 0.4472 0.5057
Leishmania major importin beta-1 subunit, putative 0.0047 0.014 0.0126
Trypanosoma brucei unspecified product 0.0166 0.0765 0.0835
Brugia malayi Hexokinase family protein 0.053 0.2665 0.3013
Toxoplasma gondii isocitrate dehydrogenase 0.0068 0.0251 0.0252
Plasmodium falciparum phd finger protein, putative 0.009 0.0365 0.0381
Brugia malayi jmjC domain containing protein 0.0294 0.1432 0.162
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0047 0.0054
Trichomonas vaginalis DNA polymerase eta, putative 0.0241 0.1157 0.1157
Onchocerca volvulus 0.1712 0.8844 0.8844
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.014 0.0158
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0062
Schistosoma mansoni smad1 5 8 and 0.0068 0.0252 0.0285
Brugia malayi AF-10 protein 0.0029 0.0049 0.0056
Leishmania major hypothetical protein, conserved 0.0293 0.1426 0.1584
Onchocerca volvulus Mothers against decapentaplegic homolog 0.003 0.0055 0.0055
Echinococcus multilocularis hexokinase type 2 0.1712 0.8844 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0241 0.1157 0.1016
Brugia malayi Beta-glucuronidase precursor 0.0163 0.075 0.0848
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0197 0.019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.0464 0.0524
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0047 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0047 0.0054
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0293 0.1426 1
Schistosoma mansoni hypothetical protein 0.0478 0.2394 0.2706
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.222 0.2486
Trichomonas vaginalis set domain proteins, putative 0.1933 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0029 0.0033
Echinococcus granulosus hexokinase type 2 0.1712 0.8844 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.0464 0.0524
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0075 0.0287 0.0293
Brugia malayi jmjC domain containing protein 0.0029 0.0047 0.0054
Brugia malayi Latrophilin receptor protein 2 0.0277 0.1344 0.152
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.0049 0.0023
Echinococcus multilocularis hexokinase 0.1712 0.8844 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1698 0.8774 0.9921
Echinococcus multilocularis jumonji domain containing protein 0.0125 0.0549 0.0621
Plasmodium vivax JmjC domain containing protein 0.0029 0.0047 0.0021
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0047 0.0054
Echinococcus granulosus jumonji domain containing protein 0.0125 0.0549 0.0621
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0387 0.0437
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0277 0.1344 0.152
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0068 0.0251 0.0284
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0024
Brugia malayi hexokinase type II 0.0544 0.2741 0.3099
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0287 0.0325
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0047 0.0054
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0047 0.0054
Trypanosoma brucei DNA polymerase IV, putative 0.0241 0.1157 0.1279
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0251 0.0284
Entamoeba histolytica deoxycytidyl transferase, putative 0.0241 0.1157 0.1308
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0267 0.0302
Brugia malayi PHD-finger family protein 0.009 0.0365 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Treponema pallidum hexokinase (hxk) 0.1712 0.8844 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0294 0.1432 0.162
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0356 0.0371
Plasmodium falciparum DNA repair protein REV1, putative 0.0075 0.0287 0.0293
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0614 0.3106 0.3512
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0241 0.1157 0.1308
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0002 0.0002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0241 0.1157 0.1308
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0267 0.0302

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 16 nM Binding affinity for sigma receptor in guinea pig brain membrane using radiolabeled ligand [3H]-(+)-SKF- 10,047 was determined ChEMBL. No reference
Ki (binding) > 10000 nM Binding affinity for dopamine receptor D2 in guinea pig striatal membrane using radiolabeled ligand [3H]-spiperone ChEMBL. No reference
Ki (binding) = 100000 nM Binding affinity of the compound towards PCP receptor in guinea pig brain membrane using radiolabeled ligand [3H]-TCP (1-[1-(2-thienyl)cyclohexyl]piperidine) was determined ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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