Detailed information for compound 1163365

Basic information

Technical information
  • TDR Targets ID: 1163365
  • Name: 3-[2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethy l-propylamino]propan-1-ol
  • MW: 371.513 | Formula: C23H33NO3
  • H donors: 1 H acceptors: 1 LogP: 4.68 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCN(CCc1ccc(c(c1)OCCc1ccccc1)OC)CCC
  • InChi: 1S/C23H33NO3/c1-3-14-24(15-7-17-25)16-12-21-10-11-22(26-2)23(19-21)27-18-13-20-8-5-4-6-9-20/h4-6,8-11,19,25H,3,7,12-18H2,1-2H3
  • InChiKey: WDJQJNKOSAYQGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl-propyl-amino]propan-1-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0039
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0088 0.0168
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0397 0.0397
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0397 0.0878
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0397 0.0878
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0149 0.0248
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0149 0.1347
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0397 0.1661
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0023 0.0038
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0088 0.0168
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0462 0.1949
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0149 0.0248
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0016 0.0027
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0187 0.3602
Schistosoma mansoni cellular tumor antigen P53 0.0096 0.1107 0.5854
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0088 0.0088
Brugia malayi ecdysteroid receptor 0.0022 0.0149 0.0248
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0016 0.0084
Brugia malayi hypothetical protein 0.0024 0.0183 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0149 0.0248
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0183 0.3519
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0397 0.0977
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0171 0.3811
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0149 0.0248
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0524 0.087
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0504 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0524 0.0628
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0462 0.9165
Loa Loa (eye worm) hypothetical protein 0.0041 0.0397 0.066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0524 0.0628
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0413 0.1017
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0397 0.0878
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0171 0.329
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0504 0.0837
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0149 0.0789
Schistosoma mansoni hypothetical protein 0.0031 0.0262 0.1387
Onchocerca volvulus 0.0026 0.0204 0.184
Brugia malayi hypothetical protein 0.0012 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0397 0.066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0149 0.0248
Loa Loa (eye worm) hypothetical protein 0.0022 0.0149 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0149 0.0248
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0369 0.0443
Entamoeba histolytica hypothetical protein 0.0039 0.0369 0.889
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0149 0.0789
Loa Loa (eye worm) hypothetical protein 0.0022 0.0149 0.0248
Leishmania major cytochrome p450-like protein 0.0025 0.0187 0.3602
Onchocerca volvulus 0.0041 0.0397 0.3588
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0524 0.0524
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0183 0.3519
Brugia malayi steroid hormone receptor 0.0022 0.0149 0.0248
Brugia malayi beta-lactamase 0.0041 0.0397 0.066
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0504 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.2277 1
Schistosoma mansoni hypothetical protein 0.0066 0.0722 0.3815
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0504 0.2132
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0023 0.0289
Echinococcus multilocularis tumor protein p63 0.0656 0.8342 0.8342
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0088 0.0105
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0397 0.1661
Echinococcus granulosus tumor protein p63 0.0656 0.8342 1
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0413 0.8108
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0149 0.0149
Brugia malayi Cytochrome P450 family protein 0.0025 0.0187 0.0311
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0204 0.0339
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0149 0.0149
Echinococcus granulosus lamin dm0 0.0026 0.0204 0.0244
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0322 0.634
Loa Loa (eye worm) hypothetical protein 0.0022 0.0149 0.0248
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0149 0.0179
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0149 0.0179
Entamoeba histolytica hypothetical protein 0.0039 0.0369 0.889
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0322 0.634
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0149 0.0789
Echinococcus multilocularis expressed protein 0.0036 0.0333 0.0333
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0016 0.0027
Brugia malayi Muscleblind-like protein 0.0161 0.1941 0.3226
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0171 0.309
Trichomonas vaginalis rotamase, putative 0.0035 0.0322 0.1329
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0322 0.634
Schistosoma mansoni hypothetical protein 0.0039 0.0369 0.1953
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0038
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0171 0.0907
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1117 0.1857
Brugia malayi Cytochrome P450 family protein 0.0015 0.0065 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0149 0.0248
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0504 0.2132
Loa Loa (eye worm) beta-lactamase 0.0041 0.0397 0.066
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0149 0.0179
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.1891 0.1891
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0397 0.0878
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0171 0.0907
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0192 0.2345 0.3896
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0397 0.1661
Echinococcus granulosus intermediate filament protein 0.0026 0.0204 0.0244
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0504 0.2662
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0149 0.0789
Loa Loa (eye worm) hypothetical protein 0.0026 0.0204 0.0339
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0171 0.0907
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0413 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0088 0.0145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0149 0.0179
Echinococcus granulosus expressed protein 0.0036 0.0333 0.04
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0397 0.0878
Onchocerca volvulus 0.0022 0.0149 0.1347
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0088 0.1593
Brugia malayi intermediate filament protein 0.0026 0.0204 0.0339
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0397 0.7853
Loa Loa (eye worm) cytochrome P450 0.0015 0.0065 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0149 0.0248
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0462 0.9165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0149 0.0248
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0183 0.0417
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0504 0.0604
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0369 0.1953
Echinococcus granulosus muscleblind protein 0.0161 0.1941 0.2327
Schistosoma mansoni hypothetical protein 0.0031 0.0262 0.1387
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0149 0.0789
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0262 0.0315
Schistosoma mansoni coup transcription factor 0.0022 0.0149 0.0789
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0397 0.0878
Mycobacterium ulcerans beta-lactamase 0.0041 0.0397 0.0878
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0171 0.0285
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0149 0.0149
Toxoplasma gondii ABC1 family protein 0.0041 0.0397 0.7853
Schistosoma mansoni intermediate filament proteins 0.0026 0.0204 0.1077
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0149 0.0248
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0504 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0016 0.0019
Trypanosoma brucei protein kinase, putative 0.0049 0.0504 1
Brugia malayi beta-lactamase family protein 0.0041 0.0397 0.066
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0149 0.0248
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0308 0.3853 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0149 0.0789
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0598 0.0993
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0722 0.1199
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0204 0.0339
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0149 0.0149
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0308 0.3853 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0262 0.0436
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0504 1
Brugia malayi hypothetical protein 0.0039 0.0369 0.0614
Loa Loa (eye worm) acetyltransferase 0.0157 0.1891 0.3143
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0149 0.0248
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0322 0.634
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0504 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0088 0.1593
Onchocerca volvulus 0.0041 0.0397 0.3588
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0012 0.0023 0.0289
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0149 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0149 0.0248
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0198 0.0328
Brugia malayi Cytochrome P450 family protein 0.0025 0.0187 0.0311
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0308 0.3853 1
Schistosoma mansoni lamin 0.0026 0.0204 0.1077
Loa Loa (eye worm) hypothetical protein 0.0022 0.0149 0.0248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0149 0.0149
Brugia malayi MAP kinase sur-1 0.0049 0.0504 0.0837
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0023 0.0028
Brugia malayi isocitrate dehydrogenase 0.0017 0.0088 0.0145
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0029 0.0029
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0149 0.0179
Echinococcus multilocularis GPCR, family 2 0.0031 0.0262 0.0262
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0308 0.3853 1
Schistosoma mansoni rotamase 0.0036 0.0333 0.1763
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0397 0.21
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0088 0.0088
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0204 0.0339
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0504 0.2132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0149 0.0248
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0462 0.1147
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0397 0.066
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0149 0.1347
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0187 0.0311
Loa Loa (eye worm) hypothetical protein 0.0161 0.1941 0.3226
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0183 0.3519
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0088 0.0145
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0504 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0149 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0149 0.0248
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0322 0.7685
Loa Loa (eye worm) hypothetical protein 0.0041 0.0397 0.066
Mycobacterium tuberculosis Conserved protein 0.0041 0.0397 0.0878
Schistosoma mansoni cytochrome P450 0.0015 0.0065 0.0341
Treponema pallidum hypothetical protein 0.0308 0.3853 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0088 0.1593
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0027
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0065 0.0077
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0504 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0397 0.066
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0029 0.0035
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0023 0.0028
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0171 0.329
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0262 0.0262
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1117 0.1857
Loa Loa (eye worm) hypothetical protein 0.0022 0.0149 0.0248
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0016 0.0084
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0149 0.0179
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0012 0.0021 0.0111
Onchocerca volvulus 0.0096 0.1107 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1117 0.1857
Leishmania major hypothetical protein, conserved 0.0041 0.0397 0.7853
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0011 0.0009 0.5
Brugia malayi hypothetical protein 0.0016 0.0071 0.0118
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0171 0.329
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0035
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0088 0.1593
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0397 0.066
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0262 0.0315
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0369 0.0369
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0183 0.0417
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0171 0.0388
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0171 0.0285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0262 0.0436
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0149 0.0789
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0023 0.0289
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0183 0.3519
Echinococcus multilocularis muscleblind protein 0.0161 0.1941 0.1941
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0504 0.0504
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0397 0.0878
Leishmania major cytochrome p450-like protein 0.0015 0.0065 0.1129
Loa Loa (eye worm) hypothetical protein 0.0022 0.0149 0.0248
Echinococcus multilocularis 0.0012 0.0023 0.0023
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0504 0.0504
Schistosoma mansoni lamin 0.0026 0.0204 0.1077
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0022 0.0149 0.0248
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0462 0.1949
Loa Loa (eye worm) hypothetical protein 0.0096 0.1107 0.184
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0149 0.0248
Mycobacterium leprae Probable lipase LipE 0.0041 0.0397 0.0878
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0047 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0183 0.0304
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.1891 0.3143
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0149 0.0179
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0322 0.634
Trichomonas vaginalis chaperonin, putative 0.0024 0.0171 0.0659
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0149 0.0149
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0171 0.0285
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0397 0.7853
Echinococcus multilocularis muscleblind protein 1 0.0161 0.1941 0.1941
Brugia malayi cytochrome P450 0.0015 0.0065 0.0107
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0397 0.7853
Loa Loa (eye worm) hypothetical protein 0.0161 0.1941 0.3226
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0088 0.0088
Brugia malayi beta-lactamase family protein 0.0041 0.0397 0.066
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0187 0.0323
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0524 0.087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0524 0.0524
Brugia malayi nuclear hormone receptor 0.0022 0.0149 0.0248
Loa Loa (eye worm) hypothetical protein 0.0097 0.1117 0.1857
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0397 0.0476
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0308 0.3853 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0065 0.1129
Trichomonas vaginalis rotamase, putative 0.0036 0.0333 0.1377
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0476 0.6017 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0149 0.0248
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0065 0.1129
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0397 0.0878
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0065 0.1129
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0262 0.0436
Loa Loa (eye worm) hypothetical protein 0.0041 0.0397 0.066
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0187 0.0311
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0187 0.3602
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0504 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0524 0.2768
Brugia malayi nuclear receptor NHR-88 0.0022 0.0149 0.0248
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0397 0.066
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0047 0.0079
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0065 0.1129
Onchocerca volvulus 0.0026 0.0204 0.184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0149 0.0248
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0023 0.0121
Brugia malayi Cytochrome P450 family protein 0.0057 0.0598 0.0993
Echinococcus granulosus lamin 0.0026 0.0204 0.0244
Schistosoma mansoni hypothetical protein 0.0031 0.0262 0.1387
Trichomonas vaginalis esterase, putative 0.0041 0.0397 0.1661
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0149 0.0248
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0088 0.1593
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0397 0.0878
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0171 0.0388
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0187 0.3602
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0149 0.0248
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0187 0.0311
Echinococcus multilocularis lamin 0.0026 0.0204 0.0204
Mycobacterium ulcerans hypothetical protein 0.0041 0.0397 0.0878
Echinococcus multilocularis 0.0015 0.0065 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0149 0.0179
Echinococcus multilocularis lamin dm0 0.0026 0.0204 0.0204
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0262 0.0436
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0149 0.1347
Entamoeba histolytica hypothetical protein 0.0039 0.0369 0.889
Mycobacterium tuberculosis Conserved protein 0.0041 0.0397 0.0878
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0397 0.1661
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0192 0.2345 0.3896
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0333 0.0554
Leishmania major cytochrome p450-like protein 0.0015 0.0065 0.1129
Echinococcus multilocularis musashi 0.0026 0.0204 0.0204
Leishmania major hypothetical protein, conserved 0.0024 0.0183 0.3519
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0262 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0149 0.0248
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0023 0.0121
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0088 0.0088
Brugia malayi nuclear receptor RXR 0.0012 0.0016 0.0027
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0045
Schistosoma mansoni hypothetical protein 0.0015 0.0065 0.0341
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.1891 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0504 0.2132
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0397 0.0878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0524 0.2768
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.1835 0.2199
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0149 0.0248
Entamoeba histolytica hypothetical protein 0.0039 0.0369 0.889
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0149 0.0248
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.3256 0.8424
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0397 0.1661
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0504 1
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0171 0.0206
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0016 0.0027
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0009 0.0009
Mycobacterium ulcerans lipase LipD 0.0041 0.0397 0.0878
Brugia malayi hypothetical protein 0.0012 0.0016 0.0027
Schistosoma mansoni hypothetical protein 0.0031 0.0262 0.1387
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0333 0.1377
Loa Loa (eye worm) hypothetical protein 0.0066 0.0722 0.1199
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0149 0.0789
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0065 0.1129
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0397 0.21
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0027
Leishmania major hypothetical protein, conserved 0.0012 0.0023 0.0289
Echinococcus granulosus GPCR family 2 0.0031 0.0262 0.0315
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0027
Brugia malayi follicle stimulating hormone receptor 0.0476 0.6017 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0171 0.0171
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0149 0.0179
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0149 0.0789
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0088 0.0463
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0504 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0088 0.1593
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0149 0.0789
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0524 0.2768
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0333 0.0554
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0065 0.1129
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0088 0.1593
Onchocerca volvulus 0.0041 0.0397 0.3588
Mycobacterium tuberculosis Conserved protein 0.0041 0.0397 0.0878
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0462 0.0554
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0171 0.329
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0149 0.0789
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0171 0.0659
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0088 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0149 0.0248
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0183 0.0417
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0149 0.0789

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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