Detailed information for compound 1167583

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 559.739 | Formula: C32H33NO4S2
  • H donors: 1 H acceptors: 2 LogP: 4.85 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H]1CCCN(C1)CCC=C(c1sccc1COc1ccccc1)c1sccc1COc1ccccc1
  • InChi: 1S/C32H33NO4S2/c34-32(35)24-9-7-17-33(21-24)18-8-14-29(30-25(15-19-38-30)22-36-27-10-3-1-4-11-27)31-26(16-20-39-31)23-37-28-12-5-2-6-13-28/h1-6,10-16,19-20,24H,7-9,17-18,21-23H2,(H,34,35)/t24-/m1/s1
  • InChiKey: UHOWRRQJOJJTKP-XMMPIXPASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH2 domain-containing protein 0.076 0.1581 0.8918
Brugia malayi CHD4 protein 0.0046 0.0037 0.005
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0518 0.1058 0.6187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0352 0.2057
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0244 0.0466 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0102 0.0158 0.0565
Schistosoma mansoni hypothetical protein 0.0269 0.0519 0.0805
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0241 0.0459 0.1681
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0138 0.0236 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0113 0.0646
Trypanosoma brucei N-myristoyl transferase, putative 0.0815 0.17 0.6318
Loa Loa (eye worm) hypothetical protein 0.0049 0.0044 0.0249
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Echinococcus granulosus dnaJ subfamily B 0.1276 0.2696 0.4241
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0046 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0518 0.1058 0.5972
Echinococcus multilocularis chromobox protein 1 0.0222 0.0419 0.065
Brugia malayi Smad1 0.0052 0.005 0.0069
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1272 0.2686 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0017 0.0081
Echinococcus granulosus histone lysine methyltransferase setb 0.0138 0.0236 0.0363
Loa Loa (eye worm) TAR-binding protein 0.0204 0.0378 0.2133
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0016 0.0017
Echinococcus granulosus chromobox protein 1 0.0222 0.0419 0.065
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0049 0.0783
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0037 0.0198
Loa Loa (eye worm) hypothetical protein 0.0273 0.0527 0.2974
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Toxoplasma gondii isocitrate dehydrogenase 0.0067 0.0083 0.0288
Plasmodium falciparum ataxin-2 like protein, putative 0.0133 0.0226 0.082
Leishmania major C-8 sterol isomerase-like protein 0.0382 0.0765 0.2824
Loa Loa (eye worm) hypothetical protein 0.0125 0.0207 0.117
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0081 0.0113 0.0164
Plasmodium vivax telomerase reverse transcriptase, putative 0.1272 0.2686 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Mycobacterium ulcerans DNA polymerase I 0.0244 0.0466 1
Trichomonas vaginalis chromobox protein, putative 0.0134 0.0228 0.1325
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0269 0.0519 0.0808
Loa Loa (eye worm) transcription factor SMAD2 0.076 0.1581 0.8918
Onchocerca volvulus 0.0036 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.058 0.1192 0.6725
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0067 0.0083 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0014 0.0066
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0046 0.0037 0.0125
Toxoplasma gondii FATC domain-containing protein 0.0046 0.0037 0.0114
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0241 0.0459 0.1681
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0018 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0241 0.0459 0.0714
Trichomonas vaginalis chromobox protein, putative 0.0134 0.0228 0.1325
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0015 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0014 0.008
Loa Loa (eye worm) hypothetical protein 0.0321 0.0631 0.356
Brugia malayi Latrophilin receptor protein 2 0.0269 0.0519 0.0715
Loa Loa (eye worm) patched family protein 0.0031 0.0006 0.0034
Leishmania major hypothetical protein, conserved 0.0035 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.0362 0.0562
Plasmodium falciparum plastid replication-repair enzyme 0.0071 0.0091 0.0317
Schistosoma mansoni hypothetical protein 0.0214 0.0402 0.062
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0045 0.0062
Toxoplasma gondii histone lysine methyltransferase SET1 0.0178 0.0324 0.1185
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1273
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0138 0.0236 0.0359
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1272 0.2686 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0526 0.1076 0.1683
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0125 0.0207 0.0201
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0015 0.0024
Schistosoma mansoni smad 0.0052 0.005 0.0066
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0017 0.0081
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0015 0.0023
Schistosoma mansoni hypothetical protein 0.1276 0.2696 0.4239
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0241 0.0459 0.1681
Echinococcus granulosus Protein patched homolog 1 0.0222 0.0419 0.0651
Trichomonas vaginalis DNA polymerase I, putative 0.0071 0.0091 0.0518
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0085 0.0122 0.0432
Loa Loa (eye worm) RNA binding protein 0.0204 0.0378 0.2133
Brugia malayi Niemann-Pick C1 protein precursor 0.0518 0.1058 0.146
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Trypanosoma cruzi target of rapamycin kinase 3 0.0192 0.0352 0.1303
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.0219 0.4545
Plasmodium vivax heterochromatin protein 1, putative 0.0036 0.0017 0.004
Echinococcus granulosus geminin 0.1254 0.2648 0.4165
Loa Loa (eye worm) hypothetical protein 0.0123 0.0203 0.1148
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Entamoeba histolytica hypothetical protein 0.0225 0.0425 0.2424
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0815 0.17 0.2671
Loa Loa (eye worm) glutathione reductase 0.0051 0.0049 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0249 0.145
Brugia malayi Bromodomain containing protein 0.0081 0.0114 0.0157
Loa Loa (eye worm) helicase 0.0036 0.0017 0.0094
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0015 0.0069
Schistosoma mansoni hypothetical protein 0.058 0.1192 0.1867
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0036 0.0017 0.0017
Trypanosoma brucei C-8 sterol isomerase, putative 0.0382 0.0765 0.2824
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0018 0.0044
Loa Loa (eye worm) Smad1 0.0052 0.005 0.0282
Loa Loa (eye worm) hypothetical protein 0.0195 0.0361 0.2034
Brugia malayi Associated with TFs and helicases family protein 0.0036 0.0017 0.0023
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0067 0.0083 0.028
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0101
Brugia malayi Pre-SET motif family protein 0.0696 0.1443 0.199
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) N-myristoyltransferase 2 0.0815 0.17 0.9594
Mycobacterium tuberculosis Conserved protein 0.0035 0.0015 0.0024
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0244 0.0466 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0249 0.145
Schistosoma mansoni hypothetical protein 0.0269 0.0519 0.0805
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.0132 0.0743
Loa Loa (eye worm) hypothetical protein 0.0138 0.0236 0.1331
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1271
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0269 0.0519 0.0808
Brugia malayi MH2 domain containing protein 0.0052 0.005 0.0069
Loa Loa (eye worm) phosphatidylinositol 3 0.0241 0.0459 0.2587
Brugia malayi chromobox protein homolog 3 0.0125 0.0207 0.0286
Schistosoma mansoni hypothetical protein 0.0052 0.0051 0.0067
Trypanosoma cruzi PAB1-binding protein , putative 0.0133 0.0226 0.0831
Schistosoma mansoni hypothetical protein 0.0225 0.0425 0.0657
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0015 0.0069
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0081 0.0113 0.0389
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0045 0.0671
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0071 0.0091 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Trypanosoma brucei N-myristoyltransferase 0.0815 0.17 0.6318
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0019 0.0108
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0123 0.0203 0.0308
Echinococcus multilocularis Chromobox protein 3 0.0036 0.0017 0.0017
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0071 0.0091 0.0328
Schistosoma mansoni bromodomain containing protein 0.014 0.024 0.0365
Trichomonas vaginalis Heterochromatin protein, putative 0.0036 0.0017 0.0081
Brugia malayi FAT domain containing protein 0.0035 0.0014 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.058 0.1192 0.1644
Echinococcus granulosus zinc finger protein 0.0047 0.0039 0.0052
Loa Loa (eye worm) hypothetical protein 0.0269 0.0519 0.2925
Toxoplasma gondii thioredoxin reductase 0.0051 0.0049 0.016
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0173 0.0313 0.1138
Echinococcus granulosus tar DNA binding protein 0.0204 0.0378 0.0587
Brugia malayi hypothetical protein 0.0031 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0101
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0045 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0045 0.0062
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0015 0.0069
Loa Loa (eye worm) hypothetical protein 0.0082 0.0114 0.0645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0382 0.2236
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.0419 0.245
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.0362 0.0562
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0051 0.0048 0.0156
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0016 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0129 0.0741
Plasmodium falciparum heterochromatin protein 1 0.0036 0.0017 0.004
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0046 0.0037 0.0044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0269 0.0519 0.0715
Schistosoma mansoni hypothetical protein 0.0269 0.0519 0.0805
Loa Loa (eye worm) patched family protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Plasmodium falciparum glutathione reductase 0.0051 0.0049 0.016
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0018 0.0096
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0269 0.0519 0.0808
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0138 0.0236 0.0359
Loa Loa (eye worm) hypothetical protein 0.0049 0.0045 0.0253
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0015 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0378 0.0583
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Brugia malayi Thioredoxin reductase 0.0051 0.0049 0.0067
Plasmodium falciparum thioredoxin reductase 0.0051 0.0049 0.016
Leishmania major phosphatidylinositol 3-kinase, putative 0.0081 0.0113 0.0389
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0045 0.0671
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0052 0.005 0.007
Entamoeba histolytica hypothetical protein 0.0046 0.0037 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0102 0.0158 0.0235
Echinococcus granulosus Smad4 0.0052 0.005 0.007
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0378 0.0583
Brugia malayi Calcitonin receptor-like protein seb-1 0.0849 0.1772 0.2444
Echinococcus granulosus TGF beta signal transducer SmadC 0.0052 0.005 0.007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0045 0.0253
Echinococcus granulosus Niemann Pick C1 protein 0.0741 0.1539 0.2417
Trypanosoma cruzi ISWI complex protein 0.0033 0.0008 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Toxoplasma gondii RNA-directed DNA polymerase 0.1272 0.2686 1
Echinococcus multilocularis GPCR, family 2 0.0269 0.0519 0.0808
Entamoeba histolytica hypothetical protein 0.0225 0.0425 0.2424
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Leishmania major trypanothione reductase 0.0051 0.0049 0.0151
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0017 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.004 0.022
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0045 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0352 0.2057
Loa Loa (eye worm) hypothetical protein 0.003 0.0003 0.0017
Mycobacterium ulcerans 5'-3' exonuclease 0.0173 0.0313 0.6614
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0017 0.0013
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0113 0.0635
Schistosoma mansoni transcription factor LCR-F1 0.0225 0.0425 0.0657
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Brugia malayi Bromodomain containing protein 0.0164 0.0294 0.0405
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0036 0.0017 0.0023
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0015 0.0024
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0103 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.0276 0.1608
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0018 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0129 0.0741
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0241 0.0459 0.0632
Brugia malayi DNA polymerase I family protein 0.0071 0.0091 0.0125
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.005 0.0282
Loa Loa (eye worm) hypothetical protein 0.015 0.0263 0.1483
Onchocerca volvulus 0.0321 0.0631 0.0625
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0045 0.0136
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0045 0.0136
Trichomonas vaginalis set domain proteins, putative 0.0792 0.165 0.9706
Echinococcus granulosus sterol regulatory element binding protein 0.0222 0.0419 0.0651
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0067 0.0083 0.0299
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0045 0.0671
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0241 0.0459 0.071
Echinococcus multilocularis Smad4 0.0052 0.005 0.007
Echinococcus multilocularis microtubule associated protein 2 0.2966 0.6349 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Brugia malayi Isocitrate dehydrogenase 0.0067 0.0083 0.0115
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Trypanosoma brucei trypanothione reductase 0.0051 0.0049 0.0151
Brugia malayi Valyl-tRNA synthetase 0.0036 0.0017 0.0023
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0067 0.0083 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.0191 0.3922
Trichomonas vaginalis N-myristoyl transferase, putative 0.0536 0.1096 0.6439
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0081 0.0113 0.0168
Onchocerca volvulus 0.0049 0.0045 0.0039
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0037 0.0198
Schistosoma mansoni zinc finger protein 0.0047 0.0039 0.0048
Echinococcus multilocularis protein dispatched 1 0.0254 0.0487 0.0758
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0382 0.0765 0.1054
Giardia lamblia CDC72 0.0815 0.17 0.5574
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Brugia malayi MH1 domain containing protein 0.0052 0.005 0.0069
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0123 0.0203 0.0311
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0101
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.0036 0.0017 0.0013
Echinococcus granulosus smad 0.0052 0.005 0.007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0696 0.1443 0.8142
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0173 0.0313 0.1155
Trypanosoma cruzi PAB1-binding protein , putative 0.0133 0.0226 0.0831
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Entamoeba histolytica hypothetical protein 0.0225 0.0425 0.2424
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0049 0.0068
Brugia malayi Heterochromatin protein 1 0.0222 0.0419 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0246 0.1432
Brugia malayi RNA recognition motif domain containing protein 0.0204 0.0378 0.0521
Loa Loa (eye worm) hypothetical protein 0.0051 0.0048 0.027
Trichomonas vaginalis N-myristoyl transferase, putative 0.0815 0.17 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1273
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0045 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0246 0.1432
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0101
Schistosoma mansoni chromobox protein 0.0222 0.0419 0.0647
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0815 0.17 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0196 0.0362 0.0499
Echinococcus granulosus Chromo domain 0.0036 0.0017 0.0017
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0046 0.0037 0.0048
Brugia malayi RNA binding protein 0.0204 0.0378 0.0521
Echinococcus multilocularis Chromo domain 0.0036 0.0017 0.0017
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0071 0.0091 0.0308
Schistosoma mansoni N-myristoyltransferase 0.0815 0.17 0.2669
Schistosoma mansoni hypothetical protein 0.0035 0.0014 0.0009
Onchocerca volvulus 0.0098 0.0149 0.0143
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Mycobacterium tuberculosis Probable reductase 0.0117 0.0191 0.3922
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0269 0.0519 0.0808
Schistosoma mansoni fkbp-rapamycin associated protein 0.0046 0.0037 0.0044
Loa Loa (eye worm) latrophilin receptor protein 2 0.0269 0.0519 0.2925
Brugia malayi M-phase phosphoprotein, mpp8 0.0036 0.0017 0.0023
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0071 0.0091 0.044
Brugia malayi Patched protein homolog 1 0.0031 0.0006 0.0008
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0067 0.0083 0.1543
Entamoeba histolytica protein kinase rad3, putative 0.0046 0.0037 0.0118
Echinococcus multilocularis Niemann Pick C1 protein 0.0518 0.1058 0.1659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Brugia malayi hypothetical protein 0.0225 0.0425 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Brugia malayi CXXC zinc finger family protein 0.009 0.0132 0.0182
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0815 0.17 0.6321
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0067 0.0083 0.0288
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0046 0.0037 0.0105
Schistosoma mansoni hypothetical protein 0.1254 0.2648 0.4163
Loa Loa (eye worm) heterochromatin protein 1 0.0222 0.0419 0.2361
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.0191 0.3922
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0045 0.0136
Echinococcus multilocularis tumor protein p63 0.219 0.4672 0.7356
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Onchocerca volvulus 0.0035 0.0015 0.0009
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0071 0.0091 0.0317
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0046 0.0037 0.0125
Onchocerca volvulus 0.0138 0.0236 0.023
Loa Loa (eye worm) hypothetical protein 0.0849 0.1772 1
Leishmania major telomerase reverse transcriptase, putative 0.1272 0.2686 1
Trichomonas vaginalis chromobox protein, putative 0.0222 0.0419 0.2448
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0134 0.0228 0.0222
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0061 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1271
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0016 0.0013
Trypanosoma cruzi N-myristoyl transferase, putative 0.0815 0.17 0.6326
Loa Loa (eye worm) hypothetical protein 0.0096 0.0145 0.0818
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0378 0.0583
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0015 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Entamoeba histolytica hypothetical protein 0.0225 0.0425 0.2424
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0017 0.004
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.0191 0.3922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0113 0.0646
Loa Loa (eye worm) hypothetical protein 0.0087 0.0125 0.0706
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0241 0.0459 0.2624
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0017 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0113 0.0646
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0037 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0138 0.0236 0.0359
Echinococcus multilocularis twinkle protein, mitochondrial 0.0052 0.0051 0.0071
Echinococcus multilocularis smad 0.0052 0.005 0.007
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0241 0.0459 0.2624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0352 0.2057
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0362 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0113 0.0646
Schistosoma mansoni hypothetical protein 0.0044 0.0033 0.0039
Brugia malayi beta-lactamase 0.0035 0.0015 0.002
Echinococcus multilocularis geminin 0.1254 0.2648 0.4165
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.0191 0.3922
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0192 0.0352 0.1285
Brugia malayi Patched related family protein 12 0.0031 0.0006 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0083 0.0122
Brugia malayi Patched related family protein 10 0.0031 0.0006 0.0008
Brugia malayi protein C24B5.3 0.0031 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.0269 0.0519 0.0805
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0049 0.0276
Schistosoma mansoni hypothetical protein 0.0052 0.0051 0.0067
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0081 0.0113 0.0168
Echinococcus granulosus tumor protein p63 0.219 0.4672 0.7356
Mycobacterium tuberculosis Conserved protein 0.0035 0.0015 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0045 0.0671
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0815 0.17 0.2671
Brugia malayi hypothetical protein 0.0031 0.0006 0.0008
Brugia malayi TAR-binding protein 0.0204 0.0378 0.0521
Loa Loa (eye worm) CHromoDomain protein family member 0.0046 0.0037 0.0206
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Brugia malayi isocitrate dehydrogenase 0.0067 0.0083 0.0115
Brugia malayi hypothetical protein 0.0031 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0123 0.0203 0.1148
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0049 0.0171
Echinococcus multilocularis Niemann Pick C1 protein 0.0741 0.1539 0.2417
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0046 0.0037 0.0118
Echinococcus multilocularis mothers against decapentaplegic 5 0.0052 0.005 0.007
Echinococcus multilocularis expressed conserved protein 0.0487 0.0991 0.1552
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0017 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.005 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1271
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.0191 0.3922
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.0219 0.4545
Brugia malayi PHD-finger family protein 0.0058 0.0064 0.0088
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0067 0.0083 0.0118
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0173 0.0313 0.1138
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0194 0.0357 0.0549
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0132 0.0223 0.0343
Toxoplasma gondii target of rapamycin (TOR), putative 0.0179 0.0325 0.1191
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0015 0.0024
Mycobacterium ulcerans hypothetical protein 0.0049 0.0045 0.0671
Echinococcus multilocularis dnaJ subfamily B 0.1276 0.2696 0.4241
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Schistosoma mansoni DNA polymerase I 0.0071 0.0091 0.013
Loa Loa (eye worm) isocitrate dehydrogenase 0.0067 0.0083 0.047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.0362 0.0562
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Echinococcus granulosus chromobox protein 1 0.0222 0.0419 0.065
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1656 0.3517 0.5536
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.0219 0.4532
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0083 0.028
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0081 0.0113 0.0409
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0225 0.0425 0.066
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Schistosoma mansoni smad1 5 8 and 0.0052 0.005 0.0066
Echinococcus granulosus Niemann Pick C1 protein 0.0518 0.1058 0.1659
Schistosoma mansoni hypothetical protein 0.0214 0.0402 0.062
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0052 0.005 0.0066
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.01 0.0154 0.0545
Brugia malayi CHE-14 protein 0.0222 0.0419 0.0578
Schistosoma mansoni patched 1 0.0222 0.0419 0.0647
Leishmania major hypothetical protein, conserved 0.0133 0.0226 0.0812
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0045 0.0693
Trypanosoma cruzi N-myristoyl transferase, putative 0.0815 0.17 0.6326
Giardia lamblia Telomerase catalytic subunit 0.1272 0.2686 1
Echinococcus granulosus Chromobox protein 3 0.0036 0.0017 0.0017
Loa Loa (eye worm) patched family protein 0.0031 0.0006 0.0034
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0017 0.0081
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0241 0.0459 0.0714
Loa Loa (eye worm) hypothetical protein 0.0046 0.0037 0.0206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.0362 0.0562
Chlamydia trachomatis DNA polymerase I 0.0244 0.0466 1
Toxoplasma gondii LsmAD domain-containing protein 0.0133 0.0226 0.082
Plasmodium vivax ataxin-2 like protein, putative 0.0133 0.0226 0.082
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0015 0.0069
Echinococcus multilocularis cpg binding protein 0.0099 0.0152 0.023
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0102 0.0158 0.0239
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0815 0.17 0.6321
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0173 0.0313 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0241 0.0459 0.2684
Echinococcus granulosus expressed conserved protein 0.0487 0.0991 0.1552
Loa Loa (eye worm) hypothetical protein 0.0791 0.1647 0.9295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0241 0.0459 0.2684
Schistosoma mansoni cellular tumor antigen P53 0.0321 0.0631 0.0982
Brugia malayi hypothetical protein 0.0031 0.0006 0.0008
Brugia malayi hypothetical protein 0.0036 0.0017 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0015 0.001
Echinococcus multilocularis sterol regulatory element binding protein 0.0222 0.0419 0.0651
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0049 0.0068
Onchocerca volvulus 0.009 0.0132 0.0126
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0035 0.0014 0.0013
Schistosoma mansoni Smad4 0.0052 0.005 0.0066
Echinococcus granulosus cpg binding protein 0.0099 0.0152 0.023
Trypanosoma brucei PAB1-binding protein , putative 0.0133 0.0226 0.0812
Onchocerca volvulus 0.0035 0.0015 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0017 0.0081
Loa Loa (eye worm) hypothetical protein 0.0382 0.0765 0.4314
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0113 0.0155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Leishmania major N-myristoyl transferase, putative 0.0815 0.17 0.6318
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.006 0.0067 0.0097
Onchocerca volvulus 0.0036 0.0017 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0133 0.0226 0.082
Toxoplasma gondii ABC1 family protein 0.0035 0.0015 0.0032
Schistosoma mansoni hypothetical protein 0.0214 0.0402 0.062
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.1254 0.2648 0.4163
Loa Loa (eye worm) patched family protein 0.0031 0.0006 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Trichomonas vaginalis chromobox protein, putative 0.0222 0.0419 0.2448
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0017 0.0081
Brugia malayi glutathione reductase 0.0051 0.0049 0.0067
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0204 0.0378 0.2133
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0123 0.0203 0.0308
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.006 0.0067 0.0097
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0114 0.0184 0.0657
Echinococcus multilocularis protein patched 0.0222 0.0419 0.0651
Brugia malayi Telomerase reverse transcriptase 0.3384 0.7252 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0133 0.0226 0.1274
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0081 0.0113 0.0389
Brugia malayi protein C24B5.3 0.0031 0.0006 0.0008
Echinococcus granulosus microtubule associated protein 2 0.2966 0.6349 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0083 0.0122
Echinococcus granulosus chromobox protein 2 0.0036 0.0017 0.0017
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0015 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0207 0.1204
Brugia malayi Patched related family protein 4 0.0031 0.0006 0.0008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0045 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0352 0.2057
Schistosoma mansoni smad1 5 8 and 0.0052 0.005 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0078 0.0441
Brugia malayi MH2 domain containing protein 0.0052 0.005 0.0069
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0015 0.0043
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0045 0.0167
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0382 0.0765 0.2838
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0015 0.0082
Plasmodium vivax glutathione reductase, putative 0.0051 0.0049 0.016
Schistosoma mansoni smad1 5 8 and 0.0052 0.005 0.0066
Mycobacterium tuberculosis Conserved protein 0.0035 0.0015 0.0024
Schistosoma mansoni chromobox protein 0.0222 0.0419 0.0647
Echinococcus multilocularis isocitrate dehydrogenase 0.0067 0.0083 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0849 0.1772 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Brugia malayi hypothetical protein 0.0133 0.0226 0.0311
Loa Loa (eye worm) hypothetical protein 0.0098 0.0149 0.0842
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0222 0.0419 0.2363
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0123 0.0203 0.0308
Trypanosoma brucei telomerase reverse transcriptase 0.1272 0.2686 1
Echinococcus granulosus GPCR family 2 0.0269 0.0519 0.0808
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0037 0.005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.0427 0.9138
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Onchocerca volvulus 0.0792 0.165 0.1645
Trichomonas vaginalis esterase, putative 0.0035 0.0015 0.0069
Echinococcus multilocularis chromobox protein 1 0.0222 0.0419 0.065
Brugia malayi SET domain containing protein 0.0042 0.0029 0.004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0132 0.0223 0.0343
Loa Loa (eye worm) hypothetical protein 0.0222 0.0419 0.2363
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0033 0.0185
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0101
Loa Loa (eye worm) hypothetical protein 0.0071 0.0091 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0036 0.0017 0.0017
Loa Loa (eye worm) twinkle helicase 0.0052 0.0051 0.0287
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0045 0.0671
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0017 0.004
Schistosoma mansoni cpg binding protein 0.0099 0.0152 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162 0.0287 0.1675
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.004 0.022
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0083 0.0299
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0192 0.0352 0.1285
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0378 0.0583
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0015 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0362 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0249 0.145
Loa Loa (eye worm) hypothetical protein 0.0049 0.0045 0.0253
Echinococcus granulosus mothers against decapentaplegic 5 0.0052 0.005 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0037 0.0201
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0123 0.0203 0.0311
Plasmodium vivax SET domain protein, putative 0.0102 0.0158 0.0565
Plasmodium vivax plastid replication-repair enzyme, putative 0.0071 0.0091 0.0317
Schistosoma mansoni cpg binding protein 0.0099 0.0152 0.0226
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0081 0.0113 0.0409
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0045 0.0671
Brugia malayi MH2 domain containing protein 0.076 0.1581 0.218
Schistosoma mansoni cpg binding protein 0.009 0.0132 0.0195
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.0191 0.3907
Echinococcus multilocularis chromobox protein 2 0.0036 0.0017 0.0017
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0241 0.0459 0.1698
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0015 0.0014
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0083 0.028
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Echinococcus multilocularis tar DNA binding protein 0.0204 0.0378 0.0587
Echinococcus multilocularis zinc finger protein 0.0047 0.0039 0.0052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0015 0.001
Schistosoma mansoni hypothetical protein 0.006 0.0067 0.0093
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0015 0.0024
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0061 0.034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0045 0.0693
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Trichomonas vaginalis hypothetical protein 0.0036 0.0017 0.0081
Schistosoma mansoni chromobox protein 0.0036 0.0017 0.0013
Brugia malayi N-myristoyltransferase 2 0.0815 0.17 0.2345
Echinococcus granulosus serine protein kinase ATM 0.0046 0.0037 0.0048
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0352 0.2057
Echinococcus granulosus fetal alzheimer antigen falz 0.0053 0.0053 0.0074
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0014 0.0019
Brugia malayi Pre-SET motif family protein 0.0102 0.0158 0.0217
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0006 0.0033
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0067 0.0083 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0015 0.0043
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0196 0.0362 0.2043
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) beta-lactamase 0.0035 0.0015 0.0082
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0173 0.0313 0.1155
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0173 0.0313 0.1145
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Onchocerca volvulus 0.0035 0.0015 0.0009
Plasmodium falciparum telomerase reverse transcriptase 0.1272 0.2686 1
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0071 0.0091 0.0328
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0071 0.0091 0.0308
Echinococcus multilocularis serine protein kinase ATM 0.0046 0.0037 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0045 0.0167
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0036 0.0017 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0037 0.0198
Brugia malayi Myosin head containing protein 0.0031 0.0006 0.0008
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0052 0.0051 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0241 0.0459 0.2684
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0035 0.0014 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0207 0.1204
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0083 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0048 0.0264
Trypanosoma cruzi ISWI complex protein 0.0033 0.0008 0.002
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0081 0.0113 0.0389
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0053 0.0053 0.0074
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0015 0.0069
Toxoplasma gondii helicase, putative 0.0071 0.0091 0.0317
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Echinococcus granulosus twinkle protein mitochondrial 0.0052 0.0051 0.0071
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Schistosoma mansoni chromobox protein 0.0036 0.0017 0.0013
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0036 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0362 0.0558
Brugia malayi MH1 domain containing protein 0.0052 0.005 0.0069
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0241 0.0459 0.1698
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0017 0.0013
Brugia malayi Protein cec-1. 0.0036 0.0017 0.0023
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0046 0.0037 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0113 0.0646
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0378 0.0583
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0225 0.0425 0.066
Brugia malayi hypothetical protein 0.0791 0.1647 0.2272
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0017 0.004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Toxoplasma gondii isocitrate dehydrogenase 0.0067 0.0083 0.0288
Treponema pallidum DNA polymerase I (polA) 0.0244 0.0466 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0096 0.0145 0.022
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0016 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0103 0.0153
Brugia malayi beta-lactamase family protein 0.0035 0.0015 0.002
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0244 0.0466 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0849 0.1772 0.2444
Onchocerca volvulus 0.0791 0.1647 0.1642
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0241 0.0459 0.1681
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0049 0.016
Schistosoma mansoni microtubule-associated protein tau 0.2966 0.6349 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0046 0.0037 0.0044
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0045 0.0167
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0173 0.0313 0.6622
Schistosoma mansoni hypothetical protein 0.0214 0.0402 0.062
Brugia malayi hypothetical protein 0.0086 0.0124 0.0171
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.0219 0.4545
Brugia malayi beta-lactamase family protein 0.0035 0.0015 0.002
Loa Loa (eye worm) patched family protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0053 0.0053 0.007
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0046 0.0037 0.0048

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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