Detailed information for compound 1169421

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 310.327 | Formula: C17H16N3O3+
  • H donors: 1 H acceptors: 2 LogP: 3.03 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C/c1n(C)cc[n+]1COC(=O)c1ccc2c(c1)cccc2
  • InChi: 1S/C17H15N3O3/c1-19-8-9-20(16(19)11-18-22)12-23-17(21)15-7-6-13-4-2-3-5-14(13)10-15/h2-11H,12H2,1H3/p+1
  • InChiKey: SHVNHEDUQYVOKZ-UHFFFAOYSA-O  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0307 0.0814 0.2879
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0209 0.0522 0.3329
Echinococcus multilocularis mitogen activated protein kinase 3 0.0209 0.0522 0.0488
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0046 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.1306 0.8693
Echinococcus granulosus mixed lineage leukemia protein mll 0.0059 0.0074 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0172 0.041 0.0738
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0046 0.0036 0.0036
Trypanosoma cruzi metacaspase 5, putative 0.0472 0.1306 0.8693
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0472 0.1306 0.1306
Schistosoma mansoni hypothetical protein 0.0172 0.041 0.041
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0063 0.0086 0.0051
Brugia malayi Cell death protein 3 precursor 0.0937 0.2691 0.9827
Schistosoma mansoni aryl hydrocarbon receptor 0.0243 0.0622 0.0622
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0209 0.0522 0.18
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0066 0.0096 0.0416
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0472 0.1306 1
Trypanosoma cruzi cytochrome P450, putative 0.0307 0.0814 0.5325
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.0482 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0059 0.0159
Schistosoma mansoni caspase-7 (C14 family) 0.0937 0.2691 0.2691
Loa Loa (eye worm) cytochrome P450 family protein 0.0448 0.1232 0.4428
Brugia malayi Intermediate filament tail domain containing protein 0.0164 0.0388 0.1303
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0046 0.0036 0.0036
Schistosoma mansoni caspase-3 (C14 family) 0.1219 0.3532 0.3532
Schistosoma mansoni intermediate filament proteins 0.0164 0.0388 0.0388
Onchocerca volvulus Cell death protein 3 homolog 0.0937 0.2691 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0172 0.041 0.0738
Echinococcus multilocularis lamin 0.0164 0.0388 0.0353
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0081 0.0081
Mycobacterium leprae Conserved hypothetical protein 0.0172 0.041 0.1492
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.007 0.0035
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0063 0.0086 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.1306 0.8693
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0066 0.0096 0.0416
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0059 0.0074 0.0039
Schistosoma mansoni hypothetical protein 0.3389 1 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0472 0.1306 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0172 0.041 0.0738
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0172 0.041 0.0738
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0472 0.1306 0.8693
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0307 0.0814 0.1616
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0172 0.041 0.0738
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0046 0.0036 0.0036
Trypanosoma brucei metacaspase MCA2 0.0472 0.1306 0.8693
Giardia lamblia Kinase, CMGC MAPK 0.0209 0.0522 0.3329
Schistosoma mansoni cpg binding protein 0.0238 0.0608 0.0608
Toxoplasma gondii histone lysine methyltransferase SET1 0.0451 0.1242 0.9497
Loa Loa (eye worm) hypothetical protein 0.0465 0.1284 0.4618
Giardia lamblia Kinase, CMGC CLK 0.0196 0.0482 0.3057
Schistosoma mansoni hypothetical protein 0.0046 0.0036 0.0036
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0536 0.1497 0.1466
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0046 0.0036 0.0036
Brugia malayi follicle stimulating hormone receptor 0.0953 0.2738 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0536 0.1497 1
Trypanosoma brucei Metacaspase-4 0.0472 0.1306 0.8693
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0172 0.041 0.0738
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0059 0.0159
Echinococcus multilocularis musashi 0.0164 0.0388 0.0353
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0081 0.0024
Loa Loa (eye worm) hypothetical protein 0.0536 0.1497 0.5407
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0472 0.1306 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0063 0.0086 0.5
Trypanosoma brucei metacaspase MCA3 0.0472 0.1306 0.8693
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0063 0.0086 0.0347
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0081 0.0359
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.1602 0.4673 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0172 0.041 0.0738
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0536 0.1497 0.1466
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0046 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0063 0.0086 0.0188
Loa Loa (eye worm) cytochrome P450 family protein 0.0307 0.0814 0.2879
Brugia malayi hypothetical protein 0.0465 0.1284 0.4618
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0081 0.0312
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0164 0.0388 0.1303
Schistosoma mansoni peptidase 0.0049 0.0046 0.0046
Brugia malayi cytochrome P450 0.0172 0.041 0.1384
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0172 0.041 0.0738
Echinococcus multilocularis apoptotic protease activating factor 1 0.0465 0.1284 0.1253
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0172 0.041 0.2559
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0046 0.0036 0.0036
Schistosoma mansoni caspase-7 (C14 family) 0.1219 0.3532 0.3532
Echinococcus multilocularis ubiquitin specific protease 41 0.0536 0.1497 0.1466
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0063 0.0086 0.0347
Trichomonas vaginalis guanylate cyclase, putative 0.0063 0.0086 0.0347
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0059 0.0159
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0196 0.0482 0.3057
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0536 0.1497 0.1497
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.007 0.0236
Echinococcus granulosus mitogen activated protein kinase 3 0.0209 0.0522 0.0488
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0172 0.041 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0059 0.0159
Brugia malayi cytoplasmic intermediate filament protein 0.0088 0.0161 0.0462
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0172 0.041 0.2559
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0086 0.0347
Schistosoma mansoni cpg binding protein 0.0252 0.0648 0.0648
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0081 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0172 0.041 0.0738
Leishmania major protein kinase, putative 0.0066 0.0096 0.0416
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0081 0.0081
Onchocerca volvulus 0.0238 0.0608 0.2153
Onchocerca volvulus 0.0063 0.0086 0.0191
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0209 0.0522 0.383
Echinococcus multilocularis caspase 3 0.0747 0.2125 0.2097
Echinococcus multilocularis cpg binding protein 0.0252 0.0648 0.0614
Loa Loa (eye worm) intermediate filament protein 0.0164 0.0388 0.1303
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0066 0.0096 0.0416
Plasmodium vivax serine/threonine kinase-1, putative 0.0196 0.0482 0.3517
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0196 0.0482 0.1653
Loa Loa (eye worm) hypothetical protein 0.0136 0.0302 0.0987
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0059 0.0159
Echinococcus multilocularis 0.0172 0.041 0.0375
Echinococcus multilocularis dnaJ subfamily B 0.3389 1 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0172 0.041 0.0738
Onchocerca volvulus 0.018 0.0434 0.15
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0472 0.1306 0.47
Echinococcus multilocularis mitogen activated protein kinase 0.0209 0.0522 0.0488
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0209 0.0522 0.3329
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0172 0.041 0.0738
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0172 0.041 0.0738
Trypanosoma cruzi metacaspase, putative 0.0472 0.1306 0.8693
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0472 0.1306 0.8693
Brugia malayi Cytochrome P450 family protein 0.0172 0.041 0.1384
Schistosoma mansoni cytochrome P450 0.0172 0.041 0.041
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0209 0.0522 0.3329
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0172 0.041 0.0738
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0046 0.0036 0.0036
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0172 0.041 0.0738
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0081 0.0024
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0172 0.041 0.0738
Echinococcus granulosus intermediate filament protein 0.0164 0.0388 0.0353
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0536 0.1497 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0059 0.0074 0.0039
Brugia malayi MAP kinase sur-1 0.0209 0.0522 0.18
Trichomonas vaginalis conserved hypothetical protein 0.0536 0.1497 1
Echinococcus granulosus cpg binding protein 0.0252 0.0648 0.0614
Brugia malayi hypothetical protein 0.0815 0.2327 0.8479
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0046 0.0036 0.0036
Trypanosoma cruzi cytochrome P450, putative 0.0307 0.0814 0.5325
Loa Loa (eye worm) cytochrome P450 0.0172 0.041 0.1384
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0172 0.041 0.0738
Echinococcus granulosus apoptotic protease activating factor 1 0.0465 0.1284 0.1253
Echinococcus multilocularis caspase 2 0.0937 0.2691 0.2665
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.1219 0.3532 0.3509
Brugia malayi Cytochrome P450 family protein 0.0448 0.1232 0.4428
Echinococcus granulosus caspase 8 0.0472 0.1306 0.1275
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0172 0.041 0.0738
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0536 0.1497 0.5407
Echinococcus granulosus dual specificity protein kinase clk2 0.0196 0.0482 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.1306 0.8693
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0472 0.1306 0.8693
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0079 0.0135 0.0099
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0196 0.0482 0.3057
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0059 0.0159
Loa Loa (eye worm) cytochrome P450 family protein 0.0307 0.0814 0.2879
Leishmania major cytochrome p450-like protein 0.0172 0.041 0.2559
Loa Loa (eye worm) hypothetical protein 0.0076 0.0126 0.0333
Loa Loa (eye worm) hypothetical protein 0.0161 0.0379 0.127
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0046 0.0036 0.0036
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0172 0.041 0.0738
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0172 0.041 0.2559
Loa Loa (eye worm) histone methyltransferase 0.0074 0.0118 0.0303
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.079 0.2253 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0172 0.041 0.0738
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0472 0.1306 0.8693
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0088 0.0161 0.0462
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0172 0.041 0.0738
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0172 0.041 0.0738
Mycobacterium leprae putative cytochrome p450 0.0172 0.041 0.1492
Loa Loa (eye worm) CXXC zinc finger family protein 0.0238 0.0608 0.2116
Echinococcus granulosus lamin dm0 0.0164 0.0388 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0059 0.0159
Trichomonas vaginalis CMGC family protein kinase 0.0209 0.0522 0.3329
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0046 0.0036 0.0036
Echinococcus granulosus aryl hydrocarbon receptor 0.0063 0.0086 0.0051
Brugia malayi CXXC zinc finger family protein 0.0238 0.0608 0.2116
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0172 0.041 0.0738
Brugia malayi bHLH-PAS transcription factor 0.018 0.0434 0.1474
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0046 0.0036 0.0036
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0063 0.0086 0.0051
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0172 0.041 0.0738
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0079 0.0135 0.0099
Schistosoma mansoni cpg binding protein 0.0252 0.0648 0.0648
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0172 0.041 0.0738
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0472 0.1306 0.8693
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0074 0.0118 0.0082
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0172 0.041 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0059 0.0159
Mycobacterium ulcerans putative regulatory protein 0.018 0.0434 0.0791
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0172 0.041 0.0738
Brugia malayi intermediate filament protein 0.0164 0.0388 0.1303
Echinococcus granulosus lamin 0.0164 0.0388 0.0353
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.007 0.007
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0046 0.0036 0.0036
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0172 0.041 0.0738
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0209 0.0522 0.3329
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.007 0.0035
Schistosoma mansoni lamin 0.0164 0.0388 0.0388
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0059 0.0074 0.0039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0536 0.1497 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0472 0.1306 0.8693
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0059 0.0159
Leishmania major metacaspase, putative 0.0472 0.1306 0.8693
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0172 0.041 0.0738
Echinococcus multilocularis dual specificity protein kinase clk2 0.0196 0.0482 0.0448
Schistosoma mansoni hypothetical protein 0.0465 0.1284 0.1284
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0074 0.0118 0.0082
Plasmodium vivax hypothetical protein, conserved 0.0472 0.1306 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0059 0.0159
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0046 0.0036 0.0036
Leishmania major protein kinase, putative 0.0066 0.0096 0.0416
Echinococcus granulosus mitogen activated protein kinase 0.0209 0.0522 0.0488
Plasmodium falciparum metacaspase-like protein 0.0472 0.1306 1
Trypanosoma cruzi metacaspase, putative 0.0472 0.1306 0.8693
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0209 0.0522 0.3329
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0063 0.0086 0.0347
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0536 0.1497 0.1466
Trypanosoma cruzi metacaspase, putative 0.0472 0.1306 0.8693
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0953 0.2738 1
Trichomonas vaginalis adenylate cyclase, putative 0.0063 0.0086 0.0347
Trypanosoma brucei protein kinase, putative 0.0209 0.0522 0.3329
Loa Loa (eye worm) hypoxia-induced factor 1 0.0752 0.2139 0.7782
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.1306 0.8693
Loa Loa (eye worm) hypothetical protein 0.0164 0.0388 0.1303
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0209 0.0522 0.3329
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0059 0.0159
Brugia malayi Cytochrome P450 family protein 0.0307 0.0814 0.2879
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.1306 0.8693
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0536 0.1497 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0172 0.041 0.0738
Loa Loa (eye worm) CYP4Cod1 0.0307 0.0814 0.2879
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0054 0.0059 0.0159
Echinococcus multilocularis 0.0193 0.0472 0.0438
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0046 0.0036 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0209 0.0522 0.3329
Toxoplasma gondii cytochrome p450 superfamily protein 0.0172 0.041 0.2944
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0172 0.041 0.0738
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0074 0.0074
Plasmodium falciparum protein serine/threonine kinase-1 0.0196 0.0482 0.3517
Echinococcus granulosus ubiquitin specific protease 41 0.0536 0.1497 0.1466
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0172 0.041 0.2559
Trichomonas vaginalis helicase, putative 0.0054 0.0059 0.0159
Echinococcus multilocularis caspase 8 0.0472 0.1306 0.1275
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0196 0.0482 0.3057
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.1306 0.8693
Trypanosoma brucei cytochrome P450, putative 0.0307 0.0814 0.5325
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0172 0.041 0.0738
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0046 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0079 0.0135 0.0366
Echinococcus granulosus caspase 2 0.0937 0.2691 0.2665
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0059 0.0159
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0196 0.0482 0.3057
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0536 0.1497 0.1466
Echinococcus granulosus single minded 2 0.018 0.0434 0.04
Leishmania major cytochrome p450-like protein 0.0172 0.041 0.2559
Schistosoma mansoni lamin 0.0164 0.0388 0.0388
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0172 0.041 0.0738
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0172 0.041 0.0738
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0046 0.0036 0.0036
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0086 0.0347
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0063 0.0086 0.0188
Trichomonas vaginalis CMGC family protein kinase 0.0209 0.0522 0.3329
Echinococcus granulosus caspase 0.1219 0.3532 0.3509
Schistosoma mansoni calpain-7 (C02 family) 0.0046 0.0036 0.0036
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0472 0.1306 0.8693
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0086 0.0347
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0172 0.041 0.0738
Echinococcus granulosus hypothetical protein 0.0193 0.0472 0.0438
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0059 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0059 0.0159
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0536 0.1497 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0054 0.0059 0.0159
Plasmodium falciparum metacaspase 1 0.0472 0.1306 1
Brugia malayi F/Y-rich N-terminus family protein 0.0073 0.0115 0.0293
Leishmania major cytochrome p450-like protein 0.0307 0.0814 0.5325
Loa Loa (eye worm) hypothetical protein 0.0815 0.2327 0.8479
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.007 0.0127
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0172 0.041 0.0738
Brugia malayi hypoxia-induced factor 1 0.0752 0.2139 0.7782
Schistosoma mansoni single-minded 0.0243 0.0622 0.0622
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0081 0.0024
Brugia malayi PAS domain containing protein 0.0243 0.0622 0.217
Trypanosoma brucei metacaspase 5, putative 0.0472 0.1306 0.8693
Echinococcus granulosus caspase 3 0.0747 0.2125 0.2097
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0172 0.041 0.0738
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0196 0.0482 0.3517
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0172 0.041 0.0738
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0536 0.1497 0.1497
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0046 0.0036 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0209 0.0522 0.3329
Trypanosoma cruzi metacaspase, putative 0.0472 0.1306 0.8693
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0196 0.0482 0.3057
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0063 0.0086 0.0347
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0046 0.0036 0.0036
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0209 0.0522 0.3329
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.1219 0.3532 0.3509
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.0522 0.0522
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0059 0.0085
Onchocerca volvulus 0.0164 0.0388 0.1326
Echinococcus multilocularis caspase 0.1219 0.3532 0.3509
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB 0.1602 0.4673 1
Echinococcus multilocularis lamin dm0 0.0164 0.0388 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0086 0.0347
Schistosoma mansoni calpain-7 (C02 family) 0.0046 0.0036 0.0036
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0472 0.1306 0.8693
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0172 0.041 0.0738
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0172 0.041 0.0738
Echinococcus multilocularis aryl hydrocarbon receptor 0.0063 0.0086 0.0051
Onchocerca volvulus 0.0164 0.0388 0.1326
Leishmania major protein kinase, putative 0.0196 0.0482 0.3057
Onchocerca volvulus 0.0465 0.1284 0.47
Trichomonas vaginalis CMGC family protein kinase 0.0196 0.0482 0.3057
Echinococcus multilocularis transfer RNA-Lys 0.018 0.0434 0.04
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0172 0.041 0.2559
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0196 0.0482 0.3057
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0536 0.1497 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0505 0.1403 0.1403
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0086 0.0347
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0059 0.0159
Trypanosoma cruzi metacaspase 5, putative 0.0472 0.1306 0.8693
Plasmodium vivax metacaspase 1, putative 0.0472 0.1306 1
Leishmania major protein kinase, putative 0.0196 0.0482 0.3057
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0086 0.0347
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0536 0.1497 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0126 0.0333
Trichomonas vaginalis guanylate cyclase, putative 0.0063 0.0086 0.0347
Loa Loa (eye worm) hypothetical protein 0.0472 0.1306 0.47
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0081 0.0024
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0536 0.1497 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0081 0.0046
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0472 0.1306 0.8693
Brugia malayi Protein kinase domain containing protein 0.0196 0.0482 0.1653
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.0482 0.0482
Trypanosoma brucei metacaspase 0.0472 0.1306 0.8693
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0066 0.0096 0.0416
Echinococcus granulosus cytochrome P450 2K1 0.0172 0.041 0.0375
Loa Loa (eye worm) hypothetical protein 0.0937 0.2691 0.9827
Loa Loa (eye worm) hypothetical protein 0.0193 0.0472 0.1616

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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