Detailed information for compound 1174661

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 288.162 | Formula: C14H12BrN2+
  • H donors: 1 H acceptors: 0 LogP: 3.88 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CC[n+]1ccc2c(c1)[nH]c1c2cc(cc1)Br
  • InChi: 1S/C14H11BrN2/c1-2-6-17-7-5-11-12-8-10(15)3-4-13(12)16-14(11)9-17/h2-5,7-9H,1,6H2/p+1
  • InChiKey: CUWXQLVLNQZNCQ-UHFFFAOYSA-O  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0104 0.0104
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0001 0.0007
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0063 0.0063
Entamoeba histolytica Ran family GTPase 0.0022 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.2382 0.6515 0.6515
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0017 0.0017
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0253 0.0253
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.3649 1 1
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0431 0.0431
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.1267 0.3447 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0005 0.0005
Leishmania major importin beta-1 subunit, putative 0.0025 0.003 0.0383
Brugia malayi ecdysteroid receptor 0.002 0.0017 0.0017
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0017 0.1768
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0031 0.0031
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0087 0.0087
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0015 0.0015
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.1267 0.3447 0.3447
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.3649 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0017 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0015 0.0042
Schistosoma mansoni hypothetical protein 0.0324 0.0854 0.0854
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0017 0.0017
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0015 0.0042
Schistosoma mansoni ran 0.0022 0.0024 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0001 0.0002
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0015 0.0015
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0001 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0292 0.0847
Entamoeba histolytica hypothetical protein 0.3649 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0017 0.0017
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0087 0.0087
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0053 0.0154
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0001 0.0002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0091 0.0264
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.3649 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0097 0.0097
Trypanosoma brucei protein kinase, putative 0.005 0.01 0.1285
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0017 0.0017
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0063 0.5617
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.01 0.1285
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0017 0.0017
Brugia malayi hypothetical protein 0.0016 0.0006 0.0006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0017 0.0017
Echinococcus multilocularis protein patched 0.0045 0.0087 0.0087
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0017
Onchocerca volvulus 0.0049 0.0097 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.0001 0.0002
Echinococcus granulosus mitogen activated protein kinase 0.005 0.01 0.01
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0103 0.1313
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0015 0.0015
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.3649 1 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0106 0.0253 0.0253
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0292 0.0847
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.1267 0.3447 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Toxoplasma gondii hypothetical protein 0.0048 0.0094 0.0094
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0015 0.0015
Leishmania major cytochrome p450-like protein 0.0014 0.0001 0.0007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0017 0.0017
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0046 0.0585
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.1267 0.3447 0.3447
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0484 0.0484
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0017 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.0001 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.0001 0.0002
Brugia malayi Cytochrome P450 family protein 0.0052 0.0104 0.0104
Entamoeba histolytica hypothetical protein 0.3649 1 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0047 0.0091 0.0091
Schistosoma mansoni importin beta-1 0.003 0.0046 0.0046
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0017 0.0017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0292 0.0292
Plasmodium falciparum importin beta, putative 0.003 0.0046 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0091 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0484 0.0484
Trichomonas vaginalis importin beta-1, putative 0.0025 0.003 0.003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0077 0.099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0484 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.035 0.4478
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2522 0.6901 0.6901
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0063 0.0063
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.01 0.1285
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0046 0.0585
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1267 0.3447 1
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.3649 1 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0024 0.0303
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0017 0.0017
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0017 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0024 0.0312
Echinococcus granulosus expressed conserved protein 0.0099 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0077 0.099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0017 0.0017
Schistosoma mansoni microtubule-associated protein tau 0.1362 0.3708 0.3708
Schistosoma mansoni serine/threonine protein kinase 0.005 0.01 0.01
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0484 0.0484
Echinococcus granulosus Niemann Pick C1 protein 0.0151 0.0377 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.0001 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.0186
Onchocerca volvulus 0.002 0.0017 0.1768
Trichomonas vaginalis CMGC family protein kinase 0.005 0.01 0.01
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0091 0.0091
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0257 0.0257
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.3649 1 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.1066
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0017 0.0017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.0005
Echinococcus multilocularis dUTP pyrophosphatase 0.3649 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0175 0.0444 0.0444
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.3649 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0091 0.0264
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0091 0.0091
Schistosoma mansoni DNA polymerase eta 0.0019 0.0015 0.0015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.2382 0.6515 0.6515
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0091 0.0091
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0063 0.0063
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.0001 0.0002
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0001 0.0001
Echinococcus granulosus snurportin 1 0.0324 0.0854 0.0854
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0292 0.0292
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0046 0.0046
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0017
Brugia malayi RNA, U transporter 1 0.0086 0.02 0.02
Echinococcus granulosus microtubule associated protein 2 0.1362 0.3708 0.3708
Trichomonas vaginalis ran, putative 0.0022 0.0024 0.0024
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0024 0.0024
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.0001 0.0002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Echinococcus multilocularis Niemann Pick C1 protein 0.0151 0.0377 0.0377
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0053 0.0154
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0063 0.0063
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0024 0.0312
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0015 0.0042
Echinococcus multilocularis snurportin 1 0.0324 0.0854 0.0854
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0063 0.0803
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0015 0.0015
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0024 0.0312
Leishmania major DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0292 0.0292
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0024 0.0071
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0017
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.1267 0.3447 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0017 0.0017
Echinococcus multilocularis dna polymerase eta 0.0019 0.0015 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0292 0.0847
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0001 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.0001 0.0002
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.01 0.01
Echinococcus multilocularis microtubule associated protein 2 0.1362 0.3708 0.3708
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.01 0.1285
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.3649 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0031 0.0393
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0017 0.0017
Brugia malayi hypothetical protein 0.0025 0.0031 0.0031
Mycobacterium leprae putative cytochrome p450 0.0014 0.0001 0.0002
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0015 0.0186
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0031 0.0031
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.0001 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.035 0.4478
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0001 0.0002
Brugia malayi Cytochrome P450 family protein 0.0014 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0031 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0015 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0091 0.1164
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.0024
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0091 0.1164
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0017 0.0017
Brugia malayi nuclear receptor NHR-88 0.002 0.0017 0.0017
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.3649 1 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Echinococcus multilocularis 0.0014 0.0001 0.0001
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0015 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0017 0.0017
Giardia lamblia Kinase, CMGC MAPK 0.005 0.01 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0017 0.0017
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0058 0.0058
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.0001 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0097 0.0097
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0024 0.0024
Brugia malayi MAP kinase sur-1 0.005 0.01 0.01
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0017 0.0017
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0087 0.0087
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0001 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0097 0.0097
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0091 0.0264
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.01 0.1285
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.0001 0.0002
Loa Loa (eye worm) dUTP diphosphatase 0.3649 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0097 0.0097
Brugia malayi Importin beta-1 subunit 0.003 0.0046 0.0046
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.003 0.003
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0063 0.0803
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0034 0.0055 0.0055
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0063 0.0803
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.003 0.0383
Echinococcus granulosus dna polymerase eta 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0046
Schistosoma mansoni nuclear hormone receptor 0.002 0.0017 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0017 0.0017
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0063 0.0063
Onchocerca volvulus 0.0047 0.0091 0.9408
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.01 0.1285
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0781 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0017
Echinococcus multilocularis tumor protein p63 0.0334 0.0881 0.0881
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0017 0.0017
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0063 0.0803
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0015 0.0015
Echinococcus granulosus dUTP pyrophosphatase 0.3649 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0017 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.01 0.1285
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0024 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0005
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0063 0.0063
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.3649 1 1
Brugia malayi cytochrome P450 0.0014 0.0001 0.0001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0292 0.0847
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0087 0.0087
Leishmania major cytochrome p450-like protein 0.0023 0.0024 0.0312
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0053 0.0154
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0063
Brugia malayi CHE-14 protein 0.0045 0.0087 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0017 0.0017
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.01 0.1285
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0005 0.0005
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0015 0.0186
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Brugia malayi Cytochrome P450 family protein 0.0023 0.0024 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0292 0.0292
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.0001 0.0002
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.0781 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.0854 0.0854
Loa Loa (eye worm) cytochrome P450 0.0014 0.0001 0.0001
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0091 0.0091
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0058 0.0058
Brugia malayi nuclear hormone receptor 0.002 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0017
Schistosoma mansoni cytochrome P450 0.0014 0.0001 0.0001
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0253 0.0253
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0001 0.0007
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0001 0.0007
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0031 0.0031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.0484 0.0484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0017 0.0017
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Schistosoma mansoni hypothetical protein 0.0044 0.0082 0.0082
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.01 0.01
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0024 0.0024
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0292 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0017 0.0017
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.3649 1 1
Echinococcus multilocularis expressed conserved protein 0.0099 0.0235 0.0235
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0001 0.0002
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0017 0.1768
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0017 0.0017
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0058 0.0169
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0001 0.0002
Echinococcus granulosus tumor protein p63 0.0334 0.0881 0.0881
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0017 0.0017
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0024 0.0303
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0017 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.0001 0.0002
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.0001 0.0002
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0063 0.0063
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0031 0.0393
Schistosoma mansoni ran 0.0022 0.0024 0.0024
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0017 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0091 0.0264
Trypanosoma brucei unspecified product 0.0019 0.0015 0.0186
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0077 0.099
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0044 0.0082 0.0082
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0091 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0091 0.0264
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0097 0.0097
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0017 0.1768
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0017 0.0017
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.3649 1 1
Leishmania major hypothetical protein, conserved 0.0025 0.0031 0.0393
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0058 0.0169
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0058 0.0058
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.01 0.01
Mycobacterium ulcerans hypothetical protein 0.0047 0.0091 0.0264
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.0001 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.0186
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0017 0.0017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0017 0.0017
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0087 0.0087
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0044 0.0082 0.0082
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0001 0.0002
Schistosoma mansoni coup transcription factor 0.002 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0017 0.0017
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0024 0.0303
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.0781 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.0253 0.0253
Entamoeba histolytica hypothetical protein 0.0025 0.003 0.003
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.0005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0063 0.0063
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0001 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.0484 0.0484
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0063 0.0063
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0091 0.0264
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0017 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0091 0.0264
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.0001 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0017 0.0017
Chlamydia trachomatis deoxycytidine triphosphate deaminase 0.1267 0.3447 0.3409
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0017 0.0017
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.3649 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0091 0.0091
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0091 0.1164
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0292 0.3737
Echinococcus granulosus GPCR family 2 0.0016 0.0005 0.0005
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0001 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0053 0.0154
Echinococcus granulosus dna polymerase kappa 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0393 0.1141
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0097 0.0097
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.035 0.4478
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0031 0.0393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0044 0.0082 0.0082
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.0001 0.0002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0091 0.0091
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.0001 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.005 0.01 0.01
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.01 0.01
Schistosoma mansoni patched 1 0.0045 0.0087 0.0087
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0001 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.005 0.01 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0186
Loa Loa (eye worm) hypothetical protein 0.0056 0.0115 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0017 0.0017
Plasmodium vivax importin-beta 2, putative 0.003 0.0046 0.0046
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0063 0.0063
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0781 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.0253 0.0253
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0001 0.0002
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0024 0.0024
Brugia malayi Cytochrome P450 family protein 0.0023 0.0024 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.0186
Schistosoma mansoni thyroid hormone receptor 0.002 0.0017 0.0017
Echinococcus granulosus FTZ F1 alpha 0.0399 0.106 0.106
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0017 0.0017
Wolbachia endosymbiont of Brugia malayi dUTPase 0.3649 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0017 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0091 0.0264
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0017 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.0001 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0484 0.0484
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0175 0.0444 0.0444
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0017 0.0017
Leishmania major DNA polymerase eta, putative 0.0019 0.0015 0.0186
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0015 0.0186
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0077 0.099
Echinococcus multilocularis protein dispatched 1 0.0052 0.0104 0.0104
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.1267 0.3447 0.3447
Brugia malayi steroid hormone receptor 0.002 0.0017 0.0017
Mycobacterium ulcerans hypothetical protein 0.0157 0.0393 0.1141
Leishmania major GTP-binding protein, putative 0.0022 0.0024 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0484 0.0484
Trichomonas vaginalis CMGC family protein kinase 0.005 0.01 0.01
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0091 0.0264
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0055 0.0055
Echinococcus multilocularis importin subunit beta 1 0.003 0.0046 0.0046
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0001 0.0007
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0091 0.0264
Leishmania major cytochrome p450-like protein 0.0014 0.0001 0.0007
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0017 0.0017
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0017 0.0017
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0017 0.0017
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.01 0.01
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.0024
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0024 0.0024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0017 0.0017
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0001 0.0002
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0087 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0091 0.0091
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.0001 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.