Detailed information for compound 1185236

Basic information

Technical information
  • TDR Targets ID: 1185236
  • Name: 2-(4-methoxyphenyl)-N-(2-pyrrolidin-1-ylethyl )acetamide
  • MW: 262.347 | Formula: C15H22N2O2
  • H donors: 1 H acceptors: 1 LogP: 1.63 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CC(=O)NCCN1CCCC1
  • InChi: 1S/C15H22N2O2/c1-19-14-6-4-13(5-7-14)12-15(18)16-8-11-17-9-2-3-10-17/h4-7H,2-3,8-12H2,1H3,(H,16,18)
  • InChiKey: YIHXROFFEIPGJX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxyphenyl)-N-(2-1-pyrrolidinylethyl)acetamide
  • 2-(4-methoxyphenyl)-N-(2-pyrrolidin-1-ylethyl)ethanamide
  • BAS 06710977
  • STK185419

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0063 0.0076 0.1097
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0139 0.1791
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0063 0.0076 0.1097
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0105 0.014 0.0409
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0116 0.0158 0.0157
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0462 0.0688 0.2068
Echinococcus granulosus survival motor neuron protein 1 0.0512 0.0764 0.0763
Entamoeba histolytica hypothetical protein 0.0116 0.0158 1
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0005 0.0013
Schistosoma mansoni glutamate synthase 0.0017 0.0005 0.0001
Giardia lamblia NADH oxidase lateral transfer candidate 0.0063 0.0076 1
Loa Loa (eye worm) beta-lactamase 0.0074 0.0093 0.1219
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0076 0.1097
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0063 0.0076 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0024 0.0271
Giardia lamblia GTOR 0.0048 0.0053 0.6766
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0073 0.0072
Plasmodium vivax thioredoxin reductase, putative 0.0182 0.0259 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.001 0.009
Brugia malayi intermediate filament protein 0.0029 0.0024 0.027
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0063 0.0076 0.1097
Echinococcus granulosus thioredoxin glutathione reductase 0.0183 0.0261 0.026
Loa Loa (eye worm) hypothetical protein 0.0445 0.0662 0.8658
Loa Loa (eye worm) hypothetical protein 0.0074 0.0093 0.1219
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0005 0.0014
Leishmania major hypothetical protein, conserved 0.0017 0.0005 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0005 0.0013
Onchocerca volvulus 0.0074 0.0093 0.1232
Schistosoma mansoni glutamate synthase 0.0017 0.0005 0.0001
Echinococcus multilocularis expressed protein 0.0018 0.0008 0.0007
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0085 0.1112
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0053 0.0747
Echinococcus multilocularis smad 0.0017 0.0006 0.0005
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0063 0.0076 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0093 0.0089
Treponema pallidum NADH oxidase 0.0063 0.0076 0.3237
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0005 0.0026
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0053 0.0747
Schistosoma mansoni cellular tumor antigen P53 0.0155 0.0217 0.0213
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0093 0.0089
Brugia malayi Thioredoxin reductase 0.0182 0.0259 0.3361
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0206 0.0202
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0053 0.0747
Loa Loa (eye worm) hypothetical protein 0.0061 0.0073 0.0962
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0053 0.0049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0053 0.0658
Echinococcus granulosus ferritin 0.0018 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0071 0.0088 0.1157
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0021 0.0641
Echinococcus granulosus peptidase Clp S14 family 0.0105 0.014 0.014
Schistosoma mansoni peptidase Clp (S14 family) 0.016 0.0225 0.0221
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0063 0.0076 0.0961
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.0662 0.8652
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0005 0.0004
Onchocerca volvulus 0.0061 0.0073 0.0946
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0063 0.0076 0.0215
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0046 0.0051 0.0623
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0011
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0093 0.1219
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0005 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0073 0.0069
Schistosoma mansoni hypothetical protein 0.0034 0.0031 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0019 0.0211
Toxoplasma gondii NADPH-glutathione reductase 0.0063 0.0076 0.2803
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0053 0.0747
Mycobacterium leprae Probable lipase LipE 0.0074 0.0093 0.0266
Onchocerca volvulus 0.0029 0.0024 0.026
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0063 0.0076 0.1097
Loa Loa (eye worm) thioredoxin reductase 0.0182 0.0259 0.3388
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.1181 0.1181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0144 0.1845
Schistosoma mansoni ferritin 0.0018 0.0008 0.0003
Brugia malayi Pre-SET motif family protein 0.0061 0.0073 0.0914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0421
Schistosoma mansoni hypothetical protein 0.0034 0.0031 0.0027
Mycobacterium ulcerans beta-lactamase 0.0074 0.0093 0.0266
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0416 0.0617 0.1853
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0024 0.027
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0021 0.0262
Plasmodium falciparum glutathione reductase 0.0182 0.0259 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0017 0.0005 0.0013
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2174 0.3314 1
Brugia malayi RhoGAP domain containing protein 0.0061 0.0073 0.0924
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0085 0.0081
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0137 0.0189 0.0188
Onchocerca volvulus 0.0074 0.0093 0.1232
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0006 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0093 0.1243
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0063 0.0076 0.1097
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0005 0.0013
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0063 0.0076 0.0215
Leishmania major trypanothione reductase 0.0182 0.0259 0.3875
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0005 0.0004
Brugia malayi MH2 domain containing protein 0.0017 0.0006 0.0039
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0073 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0038 0.0475
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0031 0.041
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0093 0.3468
Mycobacterium tuberculosis Conserved protein 0.0074 0.0093 0.0266
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.0662 1
Brugia malayi beta-lactamase family protein 0.0074 0.0093 0.1182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0421
Mycobacterium tuberculosis Conserved protein 0.0074 0.0093 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0053 0.0686
Schistosoma mansoni Smad4 0.0017 0.0006 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0038 0.0475
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.0064 0.0178
Onchocerca volvulus 0.0074 0.0093 0.1232
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0005 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0021 0.0641
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0063 0.0076 0.1097
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0093 0.0266
Loa Loa (eye worm) hypothetical protein 0.0107 0.0144 0.1879
Loa Loa (eye worm) hypothetical protein 0.0073 0.0092 0.1199
Echinococcus multilocularis peptidase Clp (S14 family) 0.0105 0.014 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0093 0.1243
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0005 0.0013
Brugia malayi hypothetical protein 0.0512 0.0764 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0416 0.0617 0.1853
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0005 0.0014
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0008 0.0007
Loa Loa (eye worm) glutathione reductase 0.0182 0.0259 0.3388
Schistosoma mansoni ferritin light chain 0.0018 0.0008 0.0003
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.0225 0.866
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0073 0.0069
Onchocerca volvulus 0.0104 0.0139 0.188
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0005 0.0014
Plasmodium falciparum thioredoxin reductase 0.0063 0.0076 0.2803
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0006 0.0005
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0005 0.0004
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.016 0.0225 0.866
Brugia malayi MH2 domain containing protein 0.0017 0.0006 0.0039
Brugia malayi MH1 domain containing protein 0.0017 0.0006 0.0039
Brugia malayi hypothetical protein 0.0018 0.0007 0.0044
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0005 0.0014
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0105 0.014 0.0409
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0073 0.2663
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0006 0.008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0144 0.1879
Schistosoma mansoni lamin 0.0029 0.0024 0.002
Plasmodium vivax SET domain protein, putative 0.0061 0.0073 0.2663
Echinococcus granulosus smad 0.0017 0.0006 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0019 0.0211
Plasmodium falciparum glutathione reductase 0.0063 0.0076 0.2803
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0064 0.232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.0264
Leishmania major NADH dehydrogenase, putative 0.0017 0.0005 0.0014
Echinococcus multilocularis GPCR, family 2 0.0034 0.0031 0.0031
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0005 0.0014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0031 0.0031
Brugia malayi MH2 domain containing protein 0.0255 0.0371 0.4838
Trypanosoma brucei trypanothione reductase 0.0182 0.0259 0.3875
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.016 0.0225 0.866
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0031 0.0371
Loa Loa (eye worm) hypothetical protein 0.0034 0.0031 0.041
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0005 0.0014
Schistosoma mansoni hypothetical protein 0.0034 0.0031 0.0027
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0006 0.0005
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2174 0.3314 1
Trichomonas vaginalis glutathione reductase, putative 0.0063 0.0076 0.1008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0416 0.0617 0.1853
Schistosoma mansoni ferritin light chain 0.0018 0.0008 0.0003
Leishmania major hypothetical protein, conserved 0.0017 0.0005 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0421
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.016 0.0225 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.016 0.0225 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0063 0.0076 0.2803
Loa Loa (eye worm) hypothetical protein 0.0074 0.0093 0.1219
Mycobacterium tuberculosis Probable oxidoreductase 0.0462 0.0688 0.2068
Brugia malayi beta-lactamase family protein 0.0074 0.0093 0.1182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0038 0.0475
Trypanosoma cruzi trypanothione reductase, putative 0.0182 0.0259 0.3875
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0093 0.1243
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0021 0.0262
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0474 0.0706 0.2122
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0093 0.0266
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0074 0.0093 0.1219
Mycobacterium ulcerans lipase LipD 0.0074 0.0093 0.0266
Loa Loa (eye worm) hypothetical protein 0.0074 0.0093 0.1219
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0008 0.0112
Echinococcus multilocularis glutamate synthase 0.0017 0.0005 0.0004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0024 0.0311
Brugia malayi TAR-binding protein 0.0069 0.0085 0.1075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0019 0.0211
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.0225 1
Schistosoma mansoni hypothetical protein 0.0034 0.0031 0.0027
Onchocerca volvulus 0.0155 0.0217 0.2963
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0024 0.0311
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0038 0.0518
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0005 0.0013
Plasmodium falciparum thioredoxin reductase 0.0182 0.0259 1
Mycobacterium ulcerans TetR family transcriptional regulator 0.2174 0.3314 1
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0206 0.0202
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0063 0.0076 0.3237
Echinococcus multilocularis Smad4 0.0017 0.0006 0.0005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0063 0.0076 0.1097
Toxoplasma gondii hypothetical protein 0.0055 0.0064 0.232
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0105 0.014 0.0409
Schistosoma mansoni smad1 5 8 and 0.0017 0.0006 0.0002
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0005 0.0004
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0005 0.0013
Echinococcus multilocularis tumor protein p63 0.1057 0.1602 0.1601
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0014 0.0155
Schistosoma mansoni glutamate synthase 0.0017 0.0005 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0076 0.1097
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0073 0.0069
Onchocerca volvulus 0.0029 0.0024 0.026
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0063 0.0076 0.2803
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0064 0.232
Trichomonas vaginalis set domain proteins, putative 0.0483 0.072 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0005 0.0004
Echinococcus multilocularis lamin 0.0029 0.0024 0.0023
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0182 0.0259 0.0768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0038 0.0475
Leishmania major hypothetical protein, conserved 0.0027 0.0021 0.0262
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0416 0.0617 0.1849
Mycobacterium tuberculosis Conserved protein 0.0074 0.0093 0.0266
Brugia malayi glutathione reductase 0.0182 0.0259 0.3361
Brugia malayi RhoGAP domain containing protein 0.0071 0.0088 0.112
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0034 0.1151
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.016 0.0225 0.0224
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0005 0.0014
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0005 0.0026
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0004 0.0003
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.016 0.0225 0.0664
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0006 0.0005
Echinococcus granulosus expressed protein 0.0018 0.0008 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0076 0.1097
Giardia lamblia Rho GAP, putative 0.0061 0.0073 0.9608
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0031 0.0371
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0069 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0093 0.1353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0421
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0005 0.0001
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0093 0.0092
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0144 0.1845
Echinococcus granulosus Smad4 0.0017 0.0006 0.0005
Echinococcus granulosus tar DNA binding protein 0.0069 0.0085 0.0084
Loa Loa (eye worm) hypothetical protein 0.0061 0.0073 0.0952
Entamoeba histolytica hypothetical protein 0.0116 0.0158 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0063 0.0076 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0042 0.0535
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0085 0.0081
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0462 0.0688 0.2064
Loa Loa (eye worm) hypothetical protein 0.0155 0.0217 0.2838
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0416 0.0617 0.1853
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0031 0.0031
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0053 0.0747
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0424 0.063 0.8243
Schistosoma mansoni intermediate filament proteins 0.0029 0.0024 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0029 0.0346
Loa Loa (eye worm) hypothetical protein 0.016 0.0225 0.2943
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0093 0.1353
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0092 0.1162
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0005 0.0067
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0046 0.0051 0.0623
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0005 0.0013
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0005 0.0014
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.0225 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0462 0.0688 0.2068
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0093 0.1182
Schistosoma mansoni lamin 0.0029 0.0024 0.002
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.0225 0.866
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0076 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0027 0.0324
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0093 0.0266
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.0662 1
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0093 0.1353
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0076 0.1097
Brugia malayi Pre-SET motif family protein 0.0424 0.063 0.8235
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0093 0.0266
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0063 0.0076 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0063 0.0076 0.3237
Echinococcus granulosus Rac GTPase activating protein 1 0.0071 0.0088 0.0088
Schistosoma mansoni ferritin 0.0018 0.0008 0.0003
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0017 0.0005 0.0013
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0038 0.0518
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0017 0.0005 0.0014
Brugia malayi hypothetical protein 0.0027 0.0021 0.024
Schistosoma mansoni ferritin 0.0018 0.0008 0.0003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0003 0.0041
Schistosoma mansoni ferritin 0.0018 0.0008 0.0003
Echinococcus multilocularis thioredoxin glutathione reductase 0.0183 0.0261 0.026
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0021 0.0641
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.028
Brugia malayi MH1 domain containing protein 0.0017 0.0006 0.0039
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0093 0.0266
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0006 0.0005
Brugia malayi beta-lactamase 0.0074 0.0093 0.1182
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0512 0.0764 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0005 0.0014
Echinococcus granulosus lamin 0.0029 0.0024 0.0023
Echinococcus granulosus tumor protein p63 0.1057 0.1602 0.1601
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0005 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0073 0.0072
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0005 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0073 0.0069
Mycobacterium ulcerans transcriptional regulator 0.2174 0.3314 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0004 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.0371 0.4859
Schistosoma mansoni smad1 5 8 and 0.0017 0.0006 0.0002
Brugia malayi Probable ClpP-like protease 0.016 0.0225 0.2914
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0005 0.0004
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0008 0.0007
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0093 0.0266
Brugia malayi glutamate synthase 0.0017 0.0005 0.0026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0031 0.0031
Schistosoma mansoni rac gtpase activating protein 0.0071 0.0088 0.0084
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0085 0.1075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0067
Schistosoma mansoni smad1 5 8 and 0.0017 0.0006 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0019 0.021
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0005 0.0013
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0005 0.0013
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0093 0.0092
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.0225 0.0664
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0005 0.0001
Schistosoma mansoni hypothetical protein 0.0104 0.0139 0.0135
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.016 0.0225 0.0224
Schistosoma mansoni survival motor neuron protein 0.0104 0.0139 0.0135
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0063 0.0076 0.1097
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0021 0.0641
Brugia malayi Smad1 0.0017 0.0006 0.0039
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0093 0.0266
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0005 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0085 0.0081
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0008 0.0112
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0085 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0085 0.0081
Leishmania major hypothetical protein, conserved 0.0017 0.0005 0.0014
Echinococcus multilocularis Rac GTPase activating protein 1 0.0071 0.0088 0.0088
Echinococcus granulosus lamin dm0 0.0029 0.0024 0.0023
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0005 0.0004
Mycobacterium tuberculosis Probable dehydrogenase 0.0416 0.0617 0.1853
Schistosoma mansoni hypothetical protein 0.0017 0.0005 0.0001
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0005 0.0004
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0005 0.0014
Mycobacterium tuberculosis Probable reductase 0.0416 0.0617 0.1853
Schistosoma mansoni smad 0.0017 0.0006 0.0002
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0053 0.315
Brugia malayi RNA binding protein 0.0069 0.0085 0.1075
Loa Loa (eye worm) RNA binding protein 0.0069 0.0085 0.1112
Trichomonas vaginalis mercuric reductase, putative 0.0063 0.0076 0.1008
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2169 0.3308 1
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0116 0.0158 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0004 0.0055
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0063 0.0076 0.0075
Schistosoma mansoni apoferritin-2 0.0018 0.0008 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0421
Echinococcus granulosus glutamate synthase 0.0017 0.0005 0.0004
Leishmania major hypothetical protein, conserved 0.0074 0.0093 0.1353
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0038 0.0518
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0008 0.0007
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0005 0.0014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0063 0.0076 0.1097
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0053 0.0697
Loa Loa (eye worm) hypothetical protein 0.0074 0.0093 0.1219
Onchocerca volvulus 0.0483 0.072 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0085 0.0081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0076 0.1097
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0076 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0024 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0053 0.0686
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0005 0.0004
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0053 0.315
Echinococcus multilocularis lamin dm0 0.0029 0.0024 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0019 0.021
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0093 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0421
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0005 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0021 0.0262
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0093 0.0266
Echinococcus multilocularis ferritin 0.0018 0.0008 0.0007
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0053 0.0052
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0005 0.0014
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0063 0.0076 0.3237
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0085 0.1112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0034 0.0421
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0093 0.0266
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0063 0.0076 0.0215
Entamoeba histolytica hypothetical protein 0.0116 0.0158 1
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0005 0.0014
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0063 0.0076 0.0215
Trichomonas vaginalis ferritin, putative 0.0018 0.0008 0.0048
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0053 0.0747
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0005 0.0067
Schistosoma mansoni hypothetical protein 0.0137 0.0189 0.0185
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0005 0.0004
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0137 0.0189 0.0188
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0074 0.0093 0.1219
Echinococcus granulosus GPCR family 2 0.0034 0.0031 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0006 0.008
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.0225 0.0664
Schistosoma mansoni apoferritin-2 0.0018 0.0008 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0512 0.0764 0.0763
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.0371 0.4859
Mycobacterium ulcerans hypothetical protein 0.0074 0.0093 0.0266
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.0662 1
Brugia malayi hypothetical protein 0.0116 0.0158 0.2034
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.0206 0.0205
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0093 0.1243
Loa Loa (eye worm) hypothetical protein 0.0227 0.0328 0.4294
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0064 0.2679
Trichomonas vaginalis esterase, putative 0.0074 0.0093 0.1243
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.03
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0093 0.1243
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0005 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0019 0.0211
Loa Loa (eye worm) Smad1 0.0017 0.0006 0.008
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0063 0.0076 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0005 0.0013
Toxoplasma gondii thioredoxin reductase 0.0182 0.0259 1
Schistosoma mansoni transcription factor LCR-F1 0.0116 0.0158 0.0154
Schistosoma mansoni hypothetical protein 0.0116 0.0158 0.0154
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0024 0.0271
Echinococcus granulosus intermediate filament protein 0.0029 0.0024 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0053 0.0686
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0116 0.0158 0.0157
Schistosoma mansoni hypothetical protein 0.0073 0.0092 0.0087
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0053 0.0052
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0063 0.0076 0.0075
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0004 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0038 0.0475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0019 0.021
Toxoplasma gondii ABC1 family protein 0.0074 0.0093 0.3468
Plasmodium vivax glutathione reductase, putative 0.0182 0.0259 1
Echinococcus multilocularis musashi 0.0029 0.0024 0.0023

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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