Detailed information for compound 1186315

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1117.23 | Formula: C54H84O24
  • H donors: 11 H acceptors: 12 LogP: -1.17 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@@H](O[C@@H]2[C@@H](C)O[C@H]([C@@H]([C@H]2O)O[C@@H]2O[C@H](C)[C@H]([C@@H]([C@H]2O)O)O)O[C@H]2[C@@H](OC[C@H]([C@@H]2O)O)O[C@H]2CC[C@]3([C@H](C2(C)C)CC=C2[C@H]3CC[C@]34[C@@]2(C)C[C@@H]([C@@H]4C(=C)C)OC3=O)C)[C@@H]([C@H]([C@@H]1O)O[C@@H]1OC[C@H]([C@@H]([C@H]1O)OC)O)O
  • InChi: 1S/C54H84O24/c1-20(2)31-27-16-53(8)24-10-11-29-51(5,6)30(13-14-52(29,7)23(24)12-15-54(31,53)50(66)73-27)74-48-43(33(59)25(56)18-69-48)78-49-44(77-46-36(62)35(61)32(58)21(3)70-46)37(63)40(22(4)71-49)75-47-39(65)42(34(60)28(17-55)72-47)76-45-38(64)41(67-9)26(57)19-68-45/h10,21-23,25-49,55-65H,1,11-19H2,2-9H3/t21-,22-,23-,25-,26-,27+,28-,29+,30+,31+,32-,33+,34-,35+,36-,37+,38-,39-,40-,41+,42+,43-,44-,45+,46+,47+,48+,49+,52-,53+,54-/m1/s1
  • InChiKey: PTGYVZJEKPFSQH-GJNCOINDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus pyruvate kinase 0.0072 0.0042 0.0042
Onchocerca volvulus Huntingtin homolog 0.0257 0.0189 0.5034
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0111 0.0109
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0031 0.0031
Trypanosoma brucei PAB1-binding protein , putative 0.0104 0.0067 0.5731
Entamoeba histolytica pyruvate kinase, putative 0.005 0.0024 0.2079
Plasmodium falciparum importin beta, putative 0.0057 0.003 0.4223
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0126 0.0084 0.0084
Brugia malayi Pre-SET motif family protein 0.0062 0.0034 0.0032
Schistosoma mansoni ran 0.0042 0.0018 0.0016
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0121 0.008 0.008
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0034 0.2562
Echinococcus granulosus lamin dm0 0.0026 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0058 0.0057
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0007 0.0383
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0007 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0151 0.0104 0.0103
Onchocerca volvulus 0.0484 0.037 1
Brugia malayi TAR-binding protein 0.0126 0.0084 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0017 0.0016
Brugia malayi nuclear receptor NHR-88 0.0041 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0121 0.008 0.008
Echinococcus multilocularis lamin 0.0026 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.0067 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0017 0.0017
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0084 0.0084
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0021 0.0134
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0964 0.0752 1
Toxoplasma gondii LsmAD domain-containing protein 0.0104 0.0067 0.5955
Entamoeba histolytica hypothetical protein 0.0046 0.0021 0.1502
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0151 0.0104 0.1359
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0136 0.0136
Mycobacterium leprae Probable lipase LipE 0.0151 0.0104 0.9191
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0018 0.2352
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0017 0.0017
Echinococcus granulosus importin subunit beta 1 0.0057 0.003 0.003
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0017 0.0017
Echinococcus multilocularis mitogen activated protein kinase 0.0158 0.011 0.011
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0078 0.0047 0.5886
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0158 0.011 1
Entamoeba histolytica Ran family GTPase 0.0042 0.0018 0.0921
Onchocerca volvulus 0.0057 0.003 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0017 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0017 0.0016
Mycobacterium ulcerans pyruvate kinase 0.0072 0.0042 0.0592
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0017 0.0016
Schistosoma mansoni loxhd1 0.0062 0.0033 0.0032
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.011 0.1498
Loa Loa (eye worm) hypothetical protein 0.0151 0.0104 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0034 0.0479
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0104 0.1409
Brugia malayi beta-lactamase family protein 0.0151 0.0104 0.0103
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0111 0.0111
Echinococcus multilocularis RUN 0.0062 0.0033 0.0033
Trypanosoma brucei pyruvate kinase 1, putative 0.0072 0.0042 0.33
Echinococcus granulosus lamin 0.0026 0.0005 0.0005
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0014 0.0157
Loa Loa (eye worm) glutaminase 0.0856 0.0666 0.0666
Schistosoma mansoni glutaminase 0.0856 0.0666 0.0665
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0018 0.148
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0017 0.0016
Echinococcus granulosus intermediate filament protein 0.0026 0.0005 0.0005
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0151 0.0104 0.1359
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0058 0.0058
Echinococcus multilocularis microtubule associated protein 2 0.2798 0.2213 0.2213
Brugia malayi jmjC domain containing protein 0.0092 0.0058 0.0056
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.001 0.0009
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0078 0.0047 0.3865
Schistosoma mansoni alpha-glucosidase 0.0137 0.0093 0.0091
Schistosoma mansoni rab6-interacting 0.0062 0.0033 0.0032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.0104 0.0103
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0017 0.0334
Trichomonas vaginalis esterase, putative 0.0151 0.0104 0.1409
Loa Loa (eye worm) hypothetical protein 0.0151 0.0104 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0017 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0017 0.0017
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0151 0.0104 0.1359
Schistosoma mansoni hypothetical protein 0.0126 0.0084 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0151 0.0104 1
Brugia malayi hypothetical protein 0.0257 0.0189 0.0187
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0017 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0017 0.0017
Echinococcus multilocularis beta LACTamase domain containing family member 0.0151 0.0104 0.0104
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0014 0.0354
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0041 0.0041
Plasmodium vivax pyruvate kinase 2, putative 0.0037 0.0014 0.1103
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0126 0.0084 0.0083
Onchocerca volvulus 0.0062 0.0033 0.0778
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0005 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0017 0.0016
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.003 0.2101
Echinococcus granulosus pyruvate kinase 0.0072 0.0042 0.0042
Loa Loa (eye worm) pyruvate kinase-PB 0.005 0.0024 0.0024
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0062 0.0033 0.0033
Entamoeba histolytica hypothetical protein 0.0109 0.0071 1
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.0042 0.0453
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0071 0.0069
Trichomonas vaginalis glutaminase, putative 0.0856 0.0666 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0158 0.011 1
Schistosoma mansoni lamin 0.0026 0.0005 0.0003
Mycobacterium ulcerans esterase/lipase LipP 0.0151 0.0104 0.1535
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0158 0.011 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0012 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0017 0.0016
Brugia malayi Bromodomain containing protein 0.0075 0.0044 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0017 0.0016
Plasmodium falciparum pyruvate kinase 2 0.0037 0.0014 0.1753
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0017 0.0017
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0031 0.0031
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0058 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0058 0.0702
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0034 0.0034
Plasmodium vivax pyruvate kinase, putative 0.0072 0.0042 0.3859
Brugia malayi Pyruvate kinase, M2 isozyme 0.0072 0.0042 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.006 0.0059
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0058 0.0058
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0014 0.0032
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.0042 0.33
Loa Loa (eye worm) hypothetical protein 0.0057 0.003 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0136 0.0136
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0017 0.0017
Trypanosoma brucei glucosidase, putative 0.0035 0.0012 0.0397
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0047 0.0527
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0126 0.0084 0.0084
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0034 0.0034
Echinococcus multilocularis GPCR, family 2 0.0126 0.0084 0.0084
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0062 0.0033 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0104 0.1409
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0005 0.0003
Schistosoma mansoni hypothetical protein 0.003 0.0008 0.0007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.0136 0.0136
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0022 0.0002 0.0000036951
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0018 0.1058
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0002 0.0002
Brugia malayi hypothetical protein 0.0067 0.0037 0.0036
Echinococcus multilocularis pyruvate kinase 0.0037 0.0014 0.0014
Schistosoma mansoni intermediate filament proteins 0.0026 0.0005 0.0003
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0012 0.0012
Leishmania major GTP-binding protein, putative 0.0042 0.0018 0.0925
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0014 0.06
Schistosoma mansoni polycystin 1-related 0.0062 0.0033 0.0032
Brugia malayi Pre-SET motif family protein 0.0425 0.0323 0.0321
Schistosoma mansoni lipoxygenase 0.0062 0.0033 0.0032
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0017 0.0016
Loa Loa (eye worm) beta-lactamase 0.0151 0.0104 0.0104
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0078 0.0047 0.0045
Echinococcus multilocularis pyruvate kinase 0.0057 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0109 0.0071 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0047 0.0527
Brugia malayi Doublecortin family protein 0.0062 0.0033 0.0032
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0017 0.0334
Plasmodium vivax SET domain protein, putative 0.0062 0.0034 0.3052
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0017 0.0017
Schistosoma mansoni bromodomain containing protein 0.0128 0.0086 0.0084
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0162 0.0113 0.1546
Brugia malayi PHD-finger family protein 0.0052 0.0026 0.0024
Brugia malayi RNA, U transporter 1 0.0162 0.0113 0.0112
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0047 0.0047
Schistosoma mansoni alpha-glucosidase 0.0137 0.0093 0.0091
Schistosoma mansoni pyruvate kinase 0.0072 0.0042 0.004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0014 0.1154
Echinococcus granulosus pyruvate kinase 0.0037 0.0014 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0058 0.0702
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.0067 0.5731
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0017 0.0017
Brugia malayi RNA binding protein 0.0126 0.0084 0.0083
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0021 0.0134
Echinococcus granulosus pyruvate kinase 0.0037 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0096 0.006 0.006
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0058 0.1458
Schistosoma mansoni alpha glucosidase 0.0035 0.0012 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0136 0.0136
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0034 0.2887
Brugia malayi Bromodomain containing protein 0.0151 0.0104 0.0103
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0007 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.006 0.006
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0017 0.0016
Brugia malayi steroid hormone receptor 0.0041 0.0017 0.0016
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0022 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0034 0.0479
Loa Loa (eye worm) hypothetical protein 0.0139 0.0095 0.0095
Schistosoma mansoni lamin 0.0026 0.0005 0.0003
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0173 0.0122 0.0122
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0084 0.0084
Onchocerca volvulus 0.0041 0.0017 0.0334
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0017 0.0016
Brugia malayi PHD-finger family protein 0.0028 0.0007 0.0005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0014 0.0014
Schistosoma mansoni ap endonuclease 0.0038 0.0014 0.0013
Mycobacterium ulcerans lipase LipD 0.0151 0.0104 0.1535
Mycobacterium ulcerans beta-lactamase 0.0151 0.0104 0.1535
Schistosoma mansoni hypothetical protein 0.0126 0.0084 0.0083
Loa Loa (eye worm) latrophilin receptor protein 2 0.0126 0.0084 0.0084
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0007 0.0007
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0162 0.0113 0.1478
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.03 0.03
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0126 0.0084 0.0084
Mycobacterium ulcerans glutaminase 0.0856 0.0666 1
Entamoeba histolytica hypothetical protein 0.0109 0.0071 1
Toxoplasma gondii pyruvate kinase PyK1 0.0072 0.0042 0.3651
Leishmania major hypothetical protein, conserved 0.0151 0.0104 0.9431
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0084 0.0084
Brugia malayi intermediate filament protein 0.0026 0.0005 0.0003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.003 0.003
Brugia malayi nuclear hormone receptor 0.0041 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0257 0.0189 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0084 0.0083
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0111 0.0111
Mycobacterium tuberculosis Probable lipase LipE 0.0151 0.0104 0.1359
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0014 0.0014
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0011 0.0009
Onchocerca volvulus Alhambra homolog 0.0028 0.0007 0.0046
Loa Loa (eye worm) hypothetical protein 0.0048 0.0023 0.0023
Onchocerca volvulus 0.0151 0.0104 0.2726
Echinococcus multilocularis mitogen activated protein kinase 3 0.0158 0.011 0.011
Echinococcus multilocularis musashi 0.0026 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0151 0.0104 0.0104
Echinococcus multilocularis lamin dm0 0.0026 0.0005 0.0005
Plasmodium falciparum LCCL domain-containing protein 0.0062 0.0033 0.4808
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0058 0.0058
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0018 0.0925
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0158 0.011 0.011
Giardia lamblia Kinase, CMGC MAPK 0.0158 0.011 1
Echinococcus multilocularis pyruvate kinase 0.0072 0.0042 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0136 0.0135
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0017 0.0017
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0845 0.0657 0.0656
Loa Loa (eye worm) hypothetical protein 0.0104 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0151 0.0104 0.0104
Mycobacterium tuberculosis Conserved protein 0.0151 0.0104 0.1359
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.0323 0.0323
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0158 0.011 1
Schistosoma mansoni hypothetical protein 0.0396 0.03 0.0298
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0021 0.1259
Giardia lamblia Pyruvate kinase 0.0037 0.0014 0.0687
Schistosoma mansoni ran 0.0042 0.0018 0.0016
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0042 0.0042
Echinococcus granulosus beta LACTamase domain containing family member 0.0151 0.0104 0.0104
Schistosoma mansoni zinc finger protein 0.0042 0.0017 0.0016
Brugia malayi hypothetical protein 0.0062 0.0033 0.0032
Mycobacterium leprae Probable pyruvate kinase PykA 0.0072 0.0042 0.3547
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0011 0.0011
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0162 0.0113 0.167
Echinococcus granulosus mitogen activated protein kinase 0.0158 0.011 0.011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0034 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0058 0.0702
Mycobacterium leprae conserved hypothetical protein 0.0151 0.0104 0.9191
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0017 0.0016
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0126 0.0084 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.0104 0.0103
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0021 0.0021
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0042 0.1011
Trichomonas vaginalis ran, putative 0.0042 0.0018 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0136 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0012 0.0397
Trypanosoma brucei hypothetical protein, conserved 0.0151 0.0104 0.9431
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0058 0.0702
Schistosoma mansoni hypothetical protein 0.0062 0.0033 0.0032
Schistosoma mansoni hypothetical protein 0.0609 0.0469 0.0468
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0017
Onchocerca volvulus 0.0151 0.0104 0.2726
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0058 0.0702
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.003 0.2101
Loa Loa (eye worm) hypothetical protein 0.0087 0.0054 0.0054
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0158 0.011 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0042 0.0042
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0071 0.0071
Brugia malayi Calcitonin receptor-like protein seb-1 0.0397 0.0301 0.0299
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0151 0.0104 0.0104
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0047 0.3774
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0017 0.0016
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0018 0.0925
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.011 0.1498
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0041 0.0041
Giardia lamblia Pyruvate kinase 0.0072 0.0042 0.3398
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0158 0.011 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0021 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0151 0.0104 0.0104
Plasmodium falciparum pyruvate kinase 0.0072 0.0042 0.6131
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0003 0.0001
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.0042 0.33
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0014 0.06
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0017 0.0017
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0058 0.49
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0007 0.0007
Onchocerca volvulus 0.0062 0.0034 0.0786
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0017 0.0017
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0078 0.0047 0.0045
Schistosoma mansoni pyruvate kinase 0.0037 0.0014 0.0012
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0011 0.0011
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0609 0.0469 0.0469
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0017
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0018 0.0018
Trypanosoma brucei protein kinase, putative 0.0158 0.011 1
Echinococcus multilocularis importin subunit beta 1 0.0057 0.003 0.003
Echinococcus multilocularis pyruvate kinase 0.0072 0.0042 0.0042
Schistosoma mansoni ap endonuclease 0.0038 0.0014 0.0013
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0017 0.0017
Plasmodium vivax multidomain scavenger receptor, putative 0.0062 0.0033 0.3027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0017 0.0017
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0158 0.011 1
Schistosoma mansoni rab6-interacting 0.0062 0.0033 0.0032
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0033 0.0033
Mycobacterium tuberculosis Probable lipase LipD 0.0151 0.0104 0.1359
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0162 0.0113 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0047 0.0527
Trypanosoma cruzi PAB1-binding protein , putative 0.0104 0.0067 0.5731
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0046 0.0021 0.002
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0084 0.0083
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0011 0.0009
Schistosoma mansoni lipoxygenase 0.0173 0.0122 0.012
Toxoplasma gondii ABC1 family protein 0.0151 0.0104 0.946
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0084 0.0083
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0058 0.0702
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0136 0.0135
Echinococcus multilocularis geminin 0.0845 0.0657 0.0657
Mycobacterium tuberculosis Conserved protein 0.0151 0.0104 0.1359
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0034 0.0033
Schistosoma mansoni hypothetical protein 0.0041 0.0017 0.0015
Schistosoma mansoni importin beta-1 0.0057 0.003 0.0028
Schistosoma mansoni cpg binding protein 0.0064 0.0035 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0034 0.0032
Mycobacterium tuberculosis Probable aminotransferase 0.0162 0.0113 0.1478
Onchocerca volvulus 0.0062 0.0033 0.0778
Trichomonas vaginalis set domain proteins, putative 0.0484 0.037 0.5466
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0042 0.1011
Plasmodium vivax ataxin-2 like protein, putative 0.0104 0.0067 0.6294
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0017 0.0016
Trypanosoma brucei polo-like protein kinase 0.0093 0.0058 0.49
Loa Loa (eye worm) hypothetical protein 0.0126 0.0084 0.0084
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0007 0.0383
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0072 0.0042 0.0524
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0173 0.0122 0.0122
Echinococcus granulosus RUN 0.0062 0.0033 0.0033
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0043 0.0041
Giardia lamblia Kinase, PLK 0.0093 0.0058 0.4974
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0003 0.0003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0033 0.0033
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0058 0.7848
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0084 0.0083
Schistosoma mansoni kinase 0.0048 0.0022 0.0021
Echinococcus multilocularis Polycystic kidney disease protein 0.0062 0.0033 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.011 0.1498
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.0042 0.0453
Loa Loa (eye worm) hypothetical protein 0.0397 0.0301 0.0301
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0003 0.0003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0111 0.0111
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0047 0.0047
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0003 0.0003
Leishmania major importin beta-1 subunit, putative 0.0046 0.0021 0.1259
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0007 0.0404
Loa Loa (eye worm) RNA binding protein 0.0126 0.0084 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0017
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0017 0.0016
Echinococcus granulosus dnaJ subfamily B 0.0396 0.03 0.03
Brugia malayi latrophilin 2 splice variant baaae 0.0272 0.02 0.0199
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0151 0.0104 0.1535
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0014 0.1834
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0014 0.06
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0078 0.0047 0.3774
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0017 0.0017
Echinococcus granulosus ubiquitin specific protease 41 0.0078 0.0047 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0017 0.0017
Echinococcus granulosus mitogen activated protein kinase 3 0.0158 0.011 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.011 0.0109
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.0104 0.1409
Onchocerca volvulus 0.0092 0.0057 0.1434
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0014 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0017 0.0017
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0078 0.0047 0.0047
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0047 0.3774
Schistosoma mansoni hypothetical protein 0.0272 0.02 0.0199
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0034 0.0424
Loa Loa (eye worm) hypothetical protein 0.5343 0.4239 0.4239
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0011 0.0011
Echinococcus multilocularis snurportin 1 0.0609 0.0469 0.0469
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0076 0.6788
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0017 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0017 0.0017
Echinococcus granulosus geminin 0.0845 0.0657 0.0657
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.0104 0.9431
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0058 0.49
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0017 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0017 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0014 0.06
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.0057 0.003 0.0028
Schistosoma mansoni coup transcription factor 0.0041 0.0017 0.0016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.0136 0.0135
Brugia malayi jmjC domain containing protein 0.0041 0.0017 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0017 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.011 0.1498
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0111 0.0111
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0058 0.0058
Chlamydia trachomatis pyruvate kinase 0.0072 0.0042 1
Brugia malayi Importin beta-1 subunit 0.0057 0.003 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0272 0.02 0.02
Entamoeba histolytica hypothetical protein 0.0109 0.0071 1
Brugia malayi Latrophilin receptor protein 2 0.0126 0.0084 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0017 0.0016
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0017 0.0016
Toxoplasma gondii pyruvate kinase PyKII 0.0037 0.0014 0.1044
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0002
Echinococcus multilocularis zinc finger protein 0.0042 0.0017 0.0017
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0017 0.0016
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0012 0.0397
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0005 0.0005
Echinococcus multilocularis pyruvate kinase 0.0037 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0017
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0003 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.0104 0.9431
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0014 0.0738
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0071 0.0071
Echinococcus multilocularis pyruvate kinase 0.0037 0.0014 0.0014
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0018 0.0018
Echinococcus multilocularis cpg binding protein 0.0064 0.0035 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0034 0.0479
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0005 0.0003
Echinococcus granulosus pyruvate kinase 0.0037 0.0014 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0034 0.0032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0017 0.0017
Onchocerca volvulus Huntingtin homolog 0.0257 0.0189 0.5034
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0042 0.0042
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0014 0.0013
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0002 0.0002
Schistosoma mansoni pyruvate kinase 0.0072 0.0042 0.004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0017 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0058 0.0702
Brugia malayi ecdysteroid receptor 0.0041 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0151 0.0104 0.0104
Echinococcus granulosus snurportin 1 0.0609 0.0469 0.0469
Brugia malayi MH2 domain containing protein 0.0234 0.0171 0.0169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0017 0.0017
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0014 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0017
Echinococcus granulosus tar DNA binding protein 0.0126 0.0084 0.0084
Brugia malayi glutaminase DH11.1 0.0856 0.0666 0.0665
Echinococcus granulosus peregrin 0.0033 0.001 0.001
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.006 0.006
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0021 0.0134
Mycobacterium ulcerans hypothetical protein 0.0162 0.0113 0.167
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0002
Brugia malayi Bromodomain containing protein 0.0033 0.001 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0084 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.006 0.0059
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0082 0.0081
Brugia malayi beta-lactamase family protein 0.0151 0.0104 0.0103
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0014 0.0177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0076 0.0044 0.0044
Echinococcus granulosus cpg binding protein 0.0064 0.0035 0.0035
Loa Loa (eye worm) glutaminase 2 0.0856 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0017
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0058 0.49
Brugia malayi hypothetical protein 0.0109 0.0071 0.0069
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.0171 0.0171
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0047 0.3774
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0017
Loa Loa (eye worm) doublecortin family protein 0.0062 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0028 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.008 0.0048 0.0048
Echinococcus granulosus zinc finger protein 0.0042 0.0017 0.0017
Echinococcus multilocularis peregrin 0.0033 0.001 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0126 0.0084 0.0084
Trypanosoma brucei pyruvate kinase 1 0.0072 0.0042 0.33
Schistosoma mansoni microtubule-associated protein tau 0.2798 0.2213 0.2212
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0034 0.2951
Brugia malayi Pyruvate kinase, muscle isozyme 0.0072 0.0042 0.004
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0017 0.0017
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0017 0.0017
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0012 0.0012
Leishmania major hypothetical protein, conserved 0.0104 0.0067 0.5731
Mycobacterium tuberculosis Probable hydrolase 0.0151 0.0104 0.1359
Echinococcus multilocularis ubiquitin specific protease 41 0.0078 0.0047 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0012 0.0397
Brugia malayi hypothetical protein 0.0104 0.0067 0.0065
Mycobacterium tuberculosis Probable esterase LipL 0.0151 0.0104 0.1359
Toxoplasma gondii exonuclease III APE 0.0038 0.0014 0.1092
Plasmodium falciparum ataxin-2 like protein, putative 0.0104 0.0067 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0007 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0017 0.0016
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0015 0.0015
Schistosoma mansoni cpg binding protein 0.0064 0.0035 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0136 0.0136
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0078 0.0047 0.0045
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0012 0.0012
Mycobacterium ulcerans hypothetical protein 0.0151 0.0104 0.1535
Leishmania major pyruvate kinase 0.0072 0.0042 0.33
Mycobacterium tuberculosis Conserved protein 0.0151 0.0104 0.1359
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.0104 0.1409
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2436 0.1925 0.1925
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.003 0.2515
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0017 0.0016
Leishmania major pyruvate kinase 0.0072 0.0042 0.33
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.0171 0.0171
Echinococcus granulosus microtubule associated protein 2 0.2798 0.2213 0.2213
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.0104 0.1409
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0002 0.0002
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0017 0.0334
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0042 0.1011
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0017 0.0016
Brugia malayi beta-lactamase 0.0151 0.0104 0.0103
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0014 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0022 0.0021
Echinococcus granulosus Aminotransferase class III 0.0023 0.0003 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0397 0.0301 0.0301
Echinococcus granulosus GPCR family 2 0.0126 0.0084 0.0084
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0845 0.0657 0.0656
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0015 0.0015
Brugia malayi CXXC zinc finger family protein 0.0057 0.003 0.0028
Schistosoma mansoni hypothetical protein 0.0126 0.0084 0.0083
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0018 0.14
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0002
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0084 0.0083
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0042 0.0042
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0018 0.0016
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0033 0.0033
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0003 0.0003
Brugia malayi MAP kinase sur-1 0.0158 0.011 0.0109
Onchocerca volvulus 0.0151 0.0104 0.2726
Brugia malayi hypothetical protein 0.0062 0.0033 0.0032
Entamoeba histolytica hypothetical protein 0.0109 0.0071 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.0189 0.0189
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0017 0.0016
Schistosoma mansoni zinc finger protein 0.003 0.0008 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0397 0.0301 0.0299
Plasmodium vivax importin-beta 2, putative 0.0057 0.003 0.2658
Echinococcus granulosus Polycystic kidney disease protein 0.0062 0.0033 0.0033
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0017 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0021 0.014
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0012 0.0899
Plasmodium falciparum phd finger protein, putative 0.0028 0.0007 0.0642
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0158 0.011 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0018 0.0925

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5 ug ml-1 Cytotoxicity against mouse P388 cells ChEMBL. 10650081
IC50 (functional) = 5 ug ml-1 Cytotoxicity against human A549 cells ChEMBL. 10650081
IC50 (functional) = 5 ug ml-1 Cytotoxicity against human HT29 cells ChEMBL. 10650081

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 10650081
Homo sapiens ChEMBL23 10650081

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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