TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 499.553 | Formula: C27H33NO8
H donors: 1 H acceptors: 2 LogP: 3 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COCCN(CC[C@H]1C2COC(=O)[C@@H]2[C@@H](c2c1cc1OCOc1c2)c1cc(OC)c(c(c1)OC)O)C
InChi: 1S/C27H33NO8/c1-28(7-8-31-2)6-5-16-17-11-20-21(36-14-35-20)12-18(17)24(25-19(16)13-34-27(25)30)15-9-22(32-3)26(29)23(10-15)33-4/h9-12,16,19,24-25,29H,5-8,13-14H2,1-4H3/t16-,19?,24-,25+/m1/s1
InChiKey: HGCZFPHUJJBGOQ-WOHBCZSASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	type IV inositol 5-phosphatase, putative	0.0012	0.0049	0.0251
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0374	0.1312
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0426	0.0426
Trichomonas vaginalis	skeletal muscle/kidney enriched inositol 5-phosphatase, putative	0.0012	0.0049	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0049	0.008
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0441	0.0728
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0501	0.0501
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0058	0.0636	0.5912
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0061	0.037
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0017	0.012	0.0421
Schistosoma mansoni	cpg binding protein	0.006	0.0651	0.3285
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0058	0.0636	0.0636
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0236
Brugia malayi	hypothetical protein	0.0038	0.0374	0.0617
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0061	0.037
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0462	0.1621
Trypanosoma brucei	polo-like protein kinase	0.0092	0.1061	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0374	0.3184
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.1126	0.3951
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0195	0.0322
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0213
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0475	0.4354
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.0049	0.008
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0579	0.0955
Plasmodium falciparum	carbon catabolite repressor protein 4, putative	0.0012	0.0049	0.0424
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.0077	0.0269
Brugia malayi	intermediate filament protein	0.0055	0.0591	0.0976
Onchocerca volvulus		0.0043	0.0441	0.2476
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0012	0.0049	0.0251
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0109	0.102
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0056	0.0611	0.1008
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0109	0.102
Trypanosoma brucei	carnitine O-palmitoyltransferase II, putative	0.0043	0.0441	0.4031
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0195	0.2813
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0195	0.0322
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0092	0.1061	0.9407
Onchocerca volvulus		0.0023	0.0195	0.1021
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.0037
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0058	0.0636	1
Trypanosoma brucei	carnitine O-acetyltransferase, putative	0.0043	0.0441	0.4031
Trypanosoma brucei	Inositol phosphosphingolipids phospholipase C	0.0012	0.0049	0.0251
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0426	0.1495
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0195	0.1565
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0462	0.1621
Trypanosoma cruzi	choline/carnitine O-acetyltransferase, putative	0.0043	0.0441	0.148
Leishmania major	pantothenate kinase subunit, putative	0.0013	0.0061	0.0043
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0012	0.0049	0.0049
Onchocerca volvulus		0.0043	0.0441	0.2476
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.2845	0.2845
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.1061	0.5351
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0475	0.4354
Trypanosoma cruzi	carnitine/choline acetyltransferase, putative	0.0043	0.0441	0.148
Schistosoma mansoni	hypothetical protein	0.004	0.0407	0.2055
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0213
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0441	0.148
Plasmodium vivax	exodeoxyribonuclease III, putative	0.0012	0.0049	0.0424
Trichomonas vaginalis	ocrl type II inositol 5-phosphatase, putative	0.0012	0.0049	0.0251
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.0037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0462	0.2331
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0012	0.0049	0.0171
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.027	0.0446
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.0049	0.0092
Schistosoma mansoni	hypothetical protein	0.0165	0.1982	1
Loa Loa (eye worm)	carnitine O-palmitoyltransferase I isoform	0.0043	0.0441	0.0728
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0195	0.2495
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1061	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0374	0.3184
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.1126	0.1126
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0462	0.0763
Trypanosoma cruzi	endonuclease/exonuclease/phosphatase, putative	0.0012	0.0049	0.0092
Onchocerca volvulus		0.0055	0.0591	0.3363
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1367	0.2257
Echinococcus multilocularis	musashi	0.0055	0.0591	0.0591
Schistosoma mansoni	hypothetical protein	0.0165	0.1982	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0049	0.008
Echinococcus granulosus	geminin	0.0165	0.1982	0.6955
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0195	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0374	0.1887
Plasmodium falciparum	endonuclease/exonuclease/phosphatase family protein, putative	0.0012	0.0049	0.0424
Entamoeba histolytica	sphingomyelinase C precursor, putative	0.0012	0.0049	0.0236
Echinococcus multilocularis	neutral sphingomyelinase	0.0012	0.0049	0.0049
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0058	0.0636	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0195	0.2813
Brugia malayi	hypothetical protein	0.001	0.0023	0.0037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0462	0.2331
Entamoeba histolytica	inositol polyphosphate-5-phosphatase, putative	0.0012	0.0049	0.0236
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0049	0.008
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0061	0.037
Schistosoma mansoni	synaptojanin	0.0012	0.0049	0.0246
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0049	0.008
Echinococcus multilocularis	cpg binding protein	0.006	0.0651	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0221	0.0365
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0195	0.2813
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.027	0.0446
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0012	0.0049	0.0171
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.0037
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0058	0.0636	0.5912
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0545	0.0899
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0023	0.0000033351
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0195	0.2813
Schistosoma mansoni	intermediate filament proteins	0.0055	0.0591	0.2982
Echinococcus granulosus	nibrin	0.001	0.0023	0.0079
Entamoeba histolytica	hypothetical protein	0.0038	0.0374	0.3184
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0058	0.0636	1
Onchocerca volvulus		0.0012	0.0049	0.0154
Echinococcus granulosus	synaptojanin 1	0.0012	0.0049	0.0171
Brugia malayi	Intermediate filament tail domain containing protein	0.0055	0.0591	0.0976
Schistosoma mansoni	hypothetical protein	0.004	0.0407	0.2055
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.0049	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0121	0.0199
Schistosoma mansoni	hypothetical protein	0.0012	0.0049	0.0246
Brugia malayi	hypothetical protein	0.001	0.0023	0.0037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0462	0.2331
Onchocerca volvulus		0.0043	0.0441	0.2476
Echinococcus granulosus	carnitine O palmitoyltransferase 2	0.0043	0.0441	0.1548
Schistosoma mansoni	nocturnin	0.0012	0.0049	0.0246
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0023	0.0000033351
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.0049	0.0251
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.0049	0.0424
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0121	0.1597
Trypanosoma cruzi	mitochondrial protein 99, putative	0.0012	0.0049	0.0092
Brugia malayi	MH2 domain containing protein	0.0116	0.1367	0.2257
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0195	0.0322
Plasmodium falciparum	exodeoxyribonuclease III, putative	0.0012	0.0049	0.0424
Schistosoma mansoni	patched 1	0.0042	0.0426	0.215
Brugia malayi	CHE-14 protein	0.0042	0.0426	0.0704
Brugia malayi	F/Y-rich N-terminus family protein	0.0017	0.0117	0.0193
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0092	0.1061	0.6142
Echinococcus granulosus	neutral sphingomyelinase	0.0012	0.0049	0.0171
Echinococcus granulosus	lamin	0.0055	0.0591	0.2074
Plasmodium vivax	endonuclease/exonuclease/phosphatase domain containing protein	0.0012	0.0049	0.0424
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0195	0.0523
Loa Loa (eye worm)	histone methyltransferase	0.0017	0.012	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0221	0.0365
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0012	0.0049	0.0251
Onchocerca volvulus	Huntingtin homolog	0.0144	0.1713	1
Plasmodium falciparum	carbon catabolite repressor protein 4, putative	0.0012	0.0049	0.0424
Giardia lamblia	Inositol 5-phosphatase 4	0.0012	0.0049	0.0251
Trypanosoma cruzi	carnitine O-palmitoyltransferase II, putative	0.0043	0.0441	0.148
Giardia lamblia	Kinase, PLK	0.0092	0.1061	1
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0061	0.037
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.2845	0.9982
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0195	0.0322
Trypanosoma brucei	carnitine O-palmitoyltransferase II, putative	0.0043	0.0441	0.4031
Brugia malayi	hypothetical protein	0.0144	0.1713	0.2828
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0213
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.0077	0.0386
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0119	0.1407	0.7099
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0058	0.0636	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0092	0.1061	0.3722
Entamoeba histolytica	inositol polyphosphate 5-phosphatase, putative	0.0012	0.0049	0.0236
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0488	0.6058	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0426	0.0704
Onchocerca volvulus	Putative neutral sphingomyelinase	0.0012	0.0049	0.0154
Plasmodium falciparum	DNase I-like protein, putative	0.0012	0.0049	0.0424
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.1653	0.1653
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0012	0.0049	0.008
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0121	0.0199
Trypanosoma cruzi	carnitine/choline acetyltransferase, putative	0.0043	0.0441	0.148
Onchocerca volvulus		0.0043	0.0441	0.2476
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.0049	0.0251
Schistosoma mansoni	neutral sphingomyelinase	0.0012	0.0049	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0234	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0426	0.0704
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0058	0.0636	0.2233
Brugia malayi	CCR4	0.0012	0.0049	0.008
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0121	0.1225
Echinococcus multilocularis	protein patched	0.0042	0.0426	0.0426
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0441	0.148
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0061	0.037
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0061	0.037
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0058	0.0636	1
Toxoplasma gondii	exonuclease III APE	0.0058	0.0636	0.5016
Schistosoma mansoni	topbp1	0.001	0.0023	0.0114
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0023	0.0114
Leishmania major	carnitine palmitoyltransferase-like protein	0.0043	0.0441	0.1401
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0195	0.0523
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.0077	0.0077
Schistosoma mansoni	choline o-acyltransferase	0.0043	0.0441	0.2225
Schistosoma mansoni	synaptojanin	0.0012	0.0049	0.0246
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.0037
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.0077	0.0077
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0462	0.0462
Schistosoma mansoni	cpg binding protein	0.0056	0.0611	0.308
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0462	0.0763
Brugia malayi	serine/threonine-protein kinase plk-2	0.0092	0.1061	0.1751
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0049	0.008
Giardia lamblia	hypothetical protein	0.0012	0.0049	0.0251
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0195	0.0322
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0058	0.0636	0.2098
Trypanosoma cruzi	Inositol phosphosphingolipids phospholipase C	0.0012	0.0049	0.0092
Schistosoma mansoni	lamin	0.0055	0.0591	0.2982
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0092	0.1061	0.1061
Trichomonas vaginalis	type II inositol 5-phosphatase, putative	0.0012	0.0049	0.0251
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0441	0.148
Trichomonas vaginalis	ap endonuclease, putative	0.0058	0.0636	0.5912
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0195	0.2813
Trypanosoma cruzi	carnitine O-acetyltransferase, putative	0.0043	0.0441	0.148
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0023	0.0000028295
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.0049	0.008
Schistosoma mansoni	DNA ligase IV	0.001	0.0023	0.0114
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0043	0.0441	0.0728
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0012	0.0049	0.0236
Echinococcus multilocularis	choline O acetyltransferase	0.0043	0.0441	0.0441
Echinococcus multilocularis	geminin	0.0165	0.1982	0.1982
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0023	0.008
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.0049	0.0092
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0023	0.0000033351
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0195	0.0322
Echinococcus multilocularis	carnitine O palmitoyltransferase 1, liver	0.0234	0.285	0.285
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0121	0.0199
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.0037
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0195	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1713	0.2828
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0109	0.102
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0092	0.1061	0.1751
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0234	0.082
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0121	0.1597
Schistosoma mansoni	kinase	0.0047	0.049	0.2472
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.0049	0.008
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0441	0.4031
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.1126	1
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0061	0.037
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0061	0.037
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0049	0.008
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0058	0.0636	0.5561
Echinococcus granulosus	expressed conserved protein	0.0091	0.1052	0.369
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1061	1
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.0049	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0049	0.008
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0002	0.001
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.0049	0.0092
Brugia malayi	topoisomerase	0.001	0.0023	0.0037
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0441	0.148
Trypanosoma brucei	inositol/phosphatidylinositol phosphatase, putative	0.0012	0.0049	0.0251
Onchocerca volvulus		0.0055	0.0591	0.3363
Brugia malayi	CXXC zinc finger family protein	0.0056	0.0611	0.1008
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0213
Onchocerca volvulus		0.0048	0.0501	0.2828
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0195	1
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0023	0.0023
Leishmania major	carnitine/choline acetyltransferase, putative	0.0043	0.0441	0.1401
Treponema pallidum	hypothetical protein	0.0012	0.0049	0.0424
Schistosoma mansoni	hypothetical protein	0.0048	0.0501	0.2526
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0213
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0049	0.008
Trypanosoma brucei	carnitine O-palmitoyltransferase, putative	0.0043	0.0441	0.4031
Brugia malayi	Choline O-acetyltransferase	0.0043	0.0441	0.0728
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0058	0.0636	0.217
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0107	0.1246	1
Echinococcus multilocularis	lamin dm0	0.0055	0.0591	0.0591
Echinococcus multilocularis	expressed conserved protein	0.0091	0.1052	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0121	0.0199
Trypanosoma brucei	RNA editing exonuclease 2	0.0012	0.0049	0.0251
Echinococcus granulosus	intermediate filament protein	0.0055	0.0591	0.2074
Brugia malayi	DKFZp564C0469 protein	0.001	0.0023	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0061	0.037
Loa Loa (eye worm)	intermediate filament protein	0.0055	0.0591	0.0976
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0236
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0195	0.2813
Trypanosoma brucei	DNA-(apurinic or apyrimidinic site) lyase, putative	0.0012	0.0049	0.0251
Echinococcus granulosus	choline O acetyltransferase	0.0043	0.0441	0.1548
Schistosoma mansoni	lamin	0.0055	0.0591	0.2982
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0055	0.0591	0.0976
Trichomonas vaginalis	helicase, putative	0.0013	0.0061	0.037
Onchocerca volvulus		0.0056	0.0611	0.3478
Trypanosoma cruzi	RNA-editing complex protein MP100, putative	0.0012	0.0049	0.0092
Echinococcus multilocularis	nibrin	0.001	0.0023	0.0023
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0012	0.0049	0.0251
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0195	0.0523
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0043	0.0441	0.0728
Trypanosoma cruzi	mitochondrial protein 99, putative	0.0012	0.0049	0.0092
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0234	0.0234
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0061	0.037
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0012	0.0049	0.0049
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0058	0.0636	0.217
Trypanosoma cruzi	inositol 5-phosphatase 1, putative	0.0012	0.0049	0.0092
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.0037
Loa Loa (eye worm)	choline/Carnitine O-acyltransferase	0.0043	0.0441	0.0728
Echinococcus granulosus	lamin dm0	0.0055	0.0591	0.2074
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1061	1
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1061	1
Echinococcus granulosus	carnitine O palmitoyltransferase 1 liver	0.0234	0.285	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.0077	0.0269
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0012	0.0049	0.0171
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.1126	0.1859
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0023	0.0000031374
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0426	0.3888
Trichomonas vaginalis	Phospholipase C precursor, putative	0.0012	0.0049	0.0251
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1061	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1367	0.2257
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.1061	0.3671
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0023	0.0037
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0234	0.285	1
Onchocerca volvulus		0.0012	0.0049	0.0154
Brugia malayi	exodeoxyribonuclease III family protein	0.0058	0.0636	0.1051
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0234	0.285	1
Loa Loa (eye worm)	hypothetical protein	0.0488	0.6058	1
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.0049	0.008
Loa Loa (eye worm)	hypothetical protein	0.0233	0.2845	0.4697
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0012	0.0049	0.0092
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0236
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0023	0.0037
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0195	0.2813
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0012	0.0049	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0061	0.037
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0501	0.0827
Brugia malayi	hypothetical protein	0.0233	0.2845	0.4697
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0061	0.037
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0441	0.148
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0049	0.008
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0213
Onchocerca volvulus	Huntingtin homolog	0.0144	0.1713	1
Schistosoma mansoni	hypothetical protein	0.004	0.0407	0.2055
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0236
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0061	0.037
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0195	0.2813
Echinococcus granulosus	traf and tnf receptor associated protein	0.0012	0.0049	0.0171
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0195	0.1565
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0012	0.0049	0.0049
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0061	0.037
Trypanosoma brucei	inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative	0.0012	0.0049	0.0251
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0012	0.0049	0.0246
Echinococcus multilocularis	synaptojanin 1	0.0012	0.0049	0.0049
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0012	0.0049	0.0092
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0121	0.1597
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0049	0.008
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0213
Schistosoma mansoni	choline o-acyltransferase	0.0043	0.0441	0.2225
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0462	0.0462
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0374	0.1887
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0591	0.0976
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0426	0.1495
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0058	0.0636	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0049	0.008
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.1145	0.5777
Schistosoma mansoni	cript-related	0.0012	0.0049	0.0246
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0012	0.0049	0.008
Trichomonas vaginalis	sphingomyelinase C 2 precursor, putative	0.0012	0.0049	0.0251
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0061	0.037
Schistosoma mansoni	hypothetical protein	0.004	0.0407	0.2055
Schistosoma mansoni	ap endonuclease	0.0058	0.0636	0.321
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1713	0.2828
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0017	0.012	0.012
Loa Loa (eye worm)	choline O-acetyltransferase	0.0043	0.0441	0.0728
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0012	0.0049	0.0049
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0092	0.1061	0.3613
Entamoeba histolytica	hypothetical protein	0.0038	0.0374	0.3184
Schistosoma mansoni	cpg binding protein	0.006	0.0651	0.3285
Plasmodium vivax	endonuclease/exonuclease/phosphatase domain containing protein	0.0012	0.0049	0.0424
Echinococcus multilocularis	carnitine O palmitoyltransferase 2	0.0043	0.0441	0.0441
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1061	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0121	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.1653	0.5797
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0012	0.0049	0.008
Schistosoma mansoni	ap endonuclease	0.0058	0.0636	0.321
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1061	1
Leishmania major	choline/Carnitine o-acyltransferase-like protein	0.0234	0.285	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0061	0.037
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0012	0.0049	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0049	0.008
Brugia malayi	Choline O-acetyltransferase	0.0043	0.0441	0.0728
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0061	0.037
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0043	0.0441	0.148
Echinococcus granulosus	cpg binding protein	0.006	0.0651	0.2285
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0058	0.0636	0.1051
Trichomonas vaginalis	ap endonuclease, putative	0.0058	0.0636	0.5912
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0121	0.0199
Trypanosoma cruzi	pantothenate kinase subunit, putative	0.0013	0.0061	0.0135
Schistosoma mansoni	carbon catabolite repressor protein	0.0012	0.0049	0.0246
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0501	0.2526
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0012	0.0049	0.0049
Schistosoma mansoni	topbp1	0.001	0.0023	0.0114
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.1061	0.3671
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0109	0.102
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1126	0.1859
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0374	0.0374
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0195	0.2495
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0012	0.0049	0.0236
Echinococcus multilocularis	lamin	0.0055	0.0591	0.0591

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1196304

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1213713