Detailed information for compound 1238079

Basic information

Technical information
  • TDR Targets ID: 1238079
  • Name: N-(2-adamantylcarbamothioyl)benzamide
  • MW: 314.445 | Formula: C18H22N2OS
  • H donors: 2 H acceptors: 1 LogP: 4.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(NC(=O)c1ccccc1)NC1C2CC3CC1CC(C2)C3
  • InChi: 1S/C18H22N2OS/c21-17(13-4-2-1-3-5-13)20-18(22)19-16-14-7-11-6-12(9-14)10-15(16)8-11/h1-5,11-12,14-16H,6-10H2,(H2,19,20,21,22)
  • InChiKey: CIEQGDRRNMOZKC-UHFFFAOYSA-N  


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Synonyms

  • N-[(2-adamantylamino)-thioxomethyl]benzamide
  • N-(2-adamantylthiocarbamoyl)benzamide
  • ZINC00469483

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0093 0.0093
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0011 0.0022 0.0068
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0093 0.0298
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0093 0.0293
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.006 0.0549 0.0969
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0093 0.0165
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0016 0.0081 0.0358
Echinococcus multilocularis expressed protein 0.0011 0.0022 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0732 0.8956
Schistosoma mansoni hypothetical protein 0.0037 0.0308 0.0982
Entamoeba histolytica hypothetical protein 0.006 0.0549 0.7041
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0213 0.097
Loa Loa (eye worm) hypothetical protein 0.0076 0.0732 0.1125
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0114 0.1145 0.2022
Schistosoma mansoni lamin 0.0022 0.0137 0.0436
Toxoplasma gondii ABC1 family protein 0.0076 0.0732 0.4373
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0093 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0256 0.2676 0.2676
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0018 0.0103 0.0103
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0732 0.404
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0093 0.0165
Mycobacterium ulcerans aldehyde dehydrogenase 0.0163 0.1675 0.7371
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0796 0.2501
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.0473
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0207
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0093 0.0093
Brugia malayi nuclear hormone receptor 0.0018 0.0093 0.0293
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0732 0.404
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0093 0.0293
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0732 0.3223
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.0815 0.1439
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0011 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0093 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0256 0.2676 0.8542
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0103 0.0569
Echinococcus granulosus lamin 0.0022 0.0137 0.0241
Onchocerca volvulus 0.0022 0.0137 0.021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0732 0.1294
Mycobacterium ulcerans beta-lactamase 0.0076 0.0732 0.3223
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0213 0.1176
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Loa Loa (eye worm) hypothetical protein 0.0076 0.0732 0.1125
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0011 0.0022 0.0068
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0033
Loa Loa (eye worm) hypothetical protein 0.0182 0.1883 0.2893
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0603 0.0603
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0779 0.343
Brugia malayi hypothetical protein 0.0011 0.0022 0.0068
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0732 0.1407
Echinococcus multilocularis dna polymerase kappa 0.0018 0.0103 0.0103
Brugia malayi Thioredoxin reductase 0.0083 0.0808 0.2539
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0011 0.0022 0.0022
Leishmania major trypanothione reductase 0.0083 0.0808 0.4459
Schistosoma mansoni hypothetical protein 0.006 0.0549 0.1751
Trypanosoma brucei DNA polymerase eta, putative 0.0018 0.0103 0.0569
Echinococcus granulosus GPCR family 2 0.0082 0.0796 0.1406
Onchocerca volvulus Cell death protein 3 homolog 0.0037 0.0308 0.0473
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.001 0.0015 0.0015
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0732 0.1407
Echinococcus granulosus carbonic anhydrase 0.0083 0.08 0.1413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0093 0.0143
Toxoplasma gondii thioredoxin reductase 0.0083 0.0808 0.4826
Schistosoma mansoni inositol monophosphatase 0.0036 0.0294 0.0938
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0732 0.1407
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0216 0.1194
Brugia malayi glutathione reductase 0.0083 0.0808 0.2539
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0216 0.0952
Echinococcus granulosus cytoplasmic intermediate filament protein 0.001 0.0015 0.0027
Schistosoma mansoni ap endonuclease 0.0016 0.0081 0.0259
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0018 0.0103 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0161 0.0515
Schistosoma mansoni hypothetical protein 0.0082 0.0796 0.2541
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0216 0.0952
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0143
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.019 0.1968 0.3783
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0213 0.041
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0011 0.0022 0.0095
Brugia malayi MH2 domain containing protein 0.0114 0.1144 0.3594
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0294 0.1621
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0143
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0003 0.001
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0114 0.1145 0.1145
Brugia malayi Pre-SET motif family protein 0.0024 0.0161 0.0507
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0603 0.1926
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0216 0.1194
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0011 0.0022 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0093 0.0143
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0093 0.0165
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0033
Echinococcus granulosus inhibitor of apoptosis protein 0.0114 0.1145 0.2022
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0093 0.0293
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0012 0.0028 0.0043
Echinococcus multilocularis carbonic anhydrase II 0.0176 0.1813 0.1813
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0213 0.0939
Trichomonas vaginalis glutaminase, putative 0.0218 0.2272 1
Echinococcus multilocularis neuropeptide s receptor 0.0531 0.5661 0.5661
Onchocerca volvulus 0.0076 0.0732 0.1125
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0603 0.0927
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0216 0.1858
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0294 0.1621
Brugia malayi hypothetical protein 0.0182 0.1883 0.5917
Onchocerca volvulus 0.0029 0.0213 0.0328
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0212 0.2199 1
Echinococcus multilocularis geminin 0.0298 0.3133 0.3133
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0093 0.0293
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0213 0.067
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0166 0.1706 0.2621
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.0103 0.0158
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0081 0.0779 0.1197
Entamoeba histolytica deoxycytidyl transferase, putative 0.0018 0.0103 0.1323
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0213 0.1176
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0093 0.0298
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0093 0.0093
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0093 0.0298
Loa Loa (eye worm) hypothetical protein 0.0076 0.0732 0.1125
Schistosoma mansoni inhibitor of apoptosis protein 0.0114 0.1145 0.3654
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0093 0.0165
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0133 0.0418
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0076 0.0732 0.1125
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0732 0.1125
Schistosoma mansoni aldehyde dehydrogenase 0.0163 0.1675 0.5345
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0216 0.0952
Trichomonas vaginalis DNA polymerase eta, putative 0.0018 0.0103 0.0454
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0732 0.3223
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0216 0.2776
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0003 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0041 0.0225
Onchocerca volvulus 0.0011 0.0022 0.0033
Loa Loa (eye worm) transcription factor SMAD2 0.0114 0.1144 0.1757
Brugia malayi RNA binding protein 0.0065 0.0603 0.1896
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0022 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0161 0.0515
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0488 0.5204 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0216 0.1194
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0011 0.0022 0.0038
Trypanosoma cruzi trypanothione reductase, putative 0.0083 0.0808 0.4459
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0093 0.0143
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0216 0.1194
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0796 0.1223
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0137 0.0429
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0732 0.3223
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0176 0.1813 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0176 0.1813 0.2784
Plasmodium falciparum carbonic anhydrase 0.0083 0.08 0.9884
Brugia malayi nuclear receptor RXR 0.0009 0.0003 0.001
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0011 0.0022 0.0069
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0093 0.0165
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0081 0.0779 0.0779
Trypanosoma brucei carbonic anhydrase-like protein 0.0176 0.1813 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0081 0.0358
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0083 0.08 0.2513
Echinococcus granulosus caspase 2 0.0037 0.0308 0.0544
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0093 0.0143
Trypanosoma brucei polo-like protein kinase 0.0081 0.0779 0.4299
Brugia malayi hypothetical protein 0.0141 0.1428 0.4487
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0093 0.0298
Brugia malayi Pre-SET motif family protein 0.0166 0.1706 0.5362
Echinococcus multilocularis GPCR, family 2 0.0082 0.0796 0.0796
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0093 0.0165
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0011 0.0022 0.0069
Brugia malayi Cell death protein 3 precursor 0.0037 0.0308 0.0967
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0253 0.0486
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0256 0.2676 0.8542
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.0103 0.0329
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0143
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0216 0.1858
Trichomonas vaginalis set domain proteins, putative 0.0189 0.1956 0.8608
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0103 0.0569
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0796 0.0796
Trypanosoma brucei unspecified product 0.0013 0.0041 0.0225
Giardia lamblia Kinase, PLK 0.0081 0.0779 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0294 0.1293
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0176 0.1813 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0796 0.1406
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0011 0.0022 0.0068
Brugia malayi ecdysteroid receptor 0.0018 0.0093 0.0293
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0732 0.404
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.0152 0.0268
Mycobacterium ulcerans aldehyde dehydrogenase 0.0163 0.1675 0.7371
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0294 0.1755
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0294 0.1293
Schistosoma mansoni GTP-binding protein alpha subunit 0.0011 0.0022 0.0069
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0213 0.0939
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0161 0.0963
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0603 0.1926
Echinococcus granulosus lamin dm0 0.0022 0.0137 0.0241
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0093 0.0293
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0081 0.0255
Onchocerca volvulus 0.0011 0.0022 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0103 0.0454
Schistosoma mansoni hypothetical protein 0.0298 0.3133 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0024
Echinococcus granulosus carbonic anhydrase 0.0083 0.08 0.1413
Brugia malayi hypothetical protein 0.0024 0.0161 0.0506
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0216 0.1858
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0093 0.0298
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0216 0.1858
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0081 0.0779 0.1377
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0011 0.0022 0.0069
Schistosoma mansoni ap endonuclease 0.0016 0.0081 0.0259
Schistosoma mansoni GTP-binding protein alpha subunit 0.0011 0.0022 0.0069
Schistosoma mansoni carbonic anhydrase-related 0.0083 0.08 0.2553
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0732 0.2301
Brugia malayi hypothetical protein 0.0009 0.0003 0.001
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0018 0.0103 0.0454
Onchocerca volvulus 0.0076 0.0732 0.1125
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0796 0.1406
Brugia malayi hypothetical protein 0.0009 0.0003 0.001
Echinococcus granulosus apoptotic protease activating factor 1 0.0037 0.0308 0.0544
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0256 0.2676 0.8542
Loa Loa (eye worm) G protein alpha subunit 3 0.0011 0.0022 0.0033
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.019 0.1968 0.3783
Onchocerca volvulus 0.0024 0.0161 0.0248
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0003 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0216 0.1194
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0011 0.0022 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0779 0.343
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0732 0.2337
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0294 0.1293
Echinococcus granulosus histone lysine methyltransferase setb 0.0024 0.0161 0.0285
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0133 0.0418
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0216 0.1194
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0732 0.3223
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0011 0.0022 0.0068
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0216 0.1292
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0011 0.0022 0.0022
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0294 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0093 0.0293
Toxoplasma gondii hypothetical protein 0.0083 0.08 0.4776
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0216 0.1194
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0732 0.3223
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0011 0.0022 0.0038
Loa Loa (eye worm) glutaminase 2 0.0218 0.2272 0.349
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0093 0.0293
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0093 0.0165
Entamoeba histolytica serine/threonine protein kinase, putative 0.0081 0.0779 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0081 0.0779 0.4299
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0216 0.069
Brugia malayi G-protein alpha subunit 0.0011 0.0022 0.0068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0216 0.1194
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0093 0.0293
Loa Loa (eye worm) hypothetical protein 0.0076 0.0732 0.1125
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0337 0.1481
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0093 0.0293
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.0815 0.0815
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0234
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0216 0.1194
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0207
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0234
Echinococcus granulosus protein quaking 0.0024 0.0161 0.0285
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0143
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0011 0.0022 0.0095
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0779 0.343
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0216 0.0952
Onchocerca volvulus Serine\/threonine kinase homolog 0.0081 0.0779 0.1197
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0011 0.0022 0.0033
Brugia malayi glutaminase DH11.1 0.0218 0.2272 0.7138
Loa Loa (eye worm) hypothetical protein 0.0114 0.1145 0.1759
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0732 0.0732
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0083 0.08 0.2513
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0093 0.0293
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0216 0.1194
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0093 0.0293
Schistosoma mansoni carbonic anhydrase 0.0083 0.08 0.2553
Mycobacterium tuberculosis Probable oxidoreductase 0.0212 0.2199 0.4226
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0011 0.0022 0.0069
Loa Loa (eye worm) thioredoxin reductase 0.0083 0.0808 0.1241
Plasmodium falciparum thioredoxin reductase 0.0083 0.0808 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0603 0.1926
Loa Loa (eye worm) hypothetical protein 0.0141 0.1428 0.2194
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0253 0.115
Schistosoma mansoni coup transcription factor 0.0018 0.0093 0.0298
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0176 0.1813 0.5695
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0212 0.2199 0.4226
Trypanosoma brucei trypanothione reductase 0.0083 0.0808 0.4459
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0093 0.0093
Echinococcus multilocularis apoptotic protease activating factor 1 0.0037 0.0308 0.0308
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0011 0.0022 0.0069
Schistosoma mansoni DNA polymerase eta 0.0018 0.0103 0.0329
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0216 0.7363
Loa Loa (eye worm) hypothetical protein 0.0178 0.1833 0.2815
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0234
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Onchocerca volvulus 0.0114 0.1145 0.1759
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0213 0.0939
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0093 0.0143
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0213 0.0939
Entamoeba histolytica hypothetical protein 0.006 0.0549 0.7041
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0213 0.0939
Echinococcus multilocularis musashi 0.0022 0.0137 0.0137
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0011 0.0022 0.0069
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0213 0.2736
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0093 0.0143
Brugia malayi beta-lactamase family protein 0.0076 0.0732 0.2301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0216 0.1194
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0093 0.0093
Brugia malayi hypothetical protein 0.0037 0.0308 0.0967
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0779 0.343
Brugia malayi beta-lactamase 0.0076 0.0732 0.2301
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0103 0.0198
Brugia malayi Temporarily assigned gene name protein 44 0.0024 0.0161 0.0506
Echinococcus multilocularis caspase 2 0.0037 0.0308 0.0308
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0103 0.0324
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0011 0.0022 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0093 0.0293
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0093 0.0093
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0018 0.0103 0.0182
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0294 0.1621
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0093 0.0293
Echinococcus multilocularis carbonic anhydrase 0.0083 0.08 0.08
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0732 0.3223
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0.0081 0.0156
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0779 0.343
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0337 0.1481
Loa Loa (eye worm) hypothetical protein 0.0024 0.0161 0.0248
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0093 0.0298
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0216 0.7363
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0779 0.2487
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0176 0.1813 0.5785
Loa Loa (eye worm) hypothetical protein 0.0037 0.0308 0.0473
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0732 0.1407
Mycobacterium tuberculosis Probable reductase 0.019 0.1968 0.3783
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0163 0.1675 0.2958
Loa Loa (eye worm) hypothetical protein 0.0141 0.1428 0.2194
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0033
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0732 0.333
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.0103 0.0329
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0114 0.1145 0.3654
Loa Loa (eye worm) hypothetical protein 0.026 0.2726 0.4188
Schistosoma mansoni hypothetical protein 0.0298 0.3133 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1145 0.1759
Echinococcus multilocularis carbonic anhydrase 0.0083 0.08 0.08
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.019 0.1968 0.3783
Loa Loa (eye worm) hypothetical protein 0.0082 0.0796 0.1223
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0135 0.0735
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0213 0.097
Loa Loa (eye worm) hypothetical protein 0.0083 0.08 0.1228
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0011 0.0022 0.0038
Mycobacterium ulcerans hypothetical protein 0.0029 0.0213 0.0939
Mycobacterium ulcerans lipase LipD 0.0076 0.0732 0.3223
Mycobacterium tuberculosis Probable dehydrogenase 0.019 0.1968 0.3783
Brugia malayi hypothetical protein 0.006 0.0549 0.1724
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0018 0.0103 0.0569
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0213 0.2736
Mycobacterium tuberculosis Conserved protein 0.0076 0.0732 0.1407
Onchocerca volvulus 0.0182 0.1883 0.2893
Brugia malayi intermediate filament protein 0.0022 0.0137 0.0429
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0011 0.0022 0.0069
Brugia malayi steroid hormone receptor 0.0018 0.0093 0.0293
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0022 0.0095
Loa Loa (eye worm) hydrolase 0.0609 0.651 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0093 0.0298
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0163 0.1675 0.1675
Leishmania major hypothetical protein, conserved 0.0076 0.0732 0.404
Trypanosoma cruzi DNA polymerase eta, putative 0.0018 0.0103 0.0569
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0207
Schistosoma mansoni hypothetical protein 0.0082 0.0796 0.2541
Echinococcus multilocularis lamin dm0 0.0022 0.0137 0.0137
Brugia malayi TAR-binding protein 0.0065 0.0603 0.1896
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0216 0.1194
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0216 1
Echinococcus granulosus carbonic anhydrase 0.0083 0.08 0.1413
Onchocerca volvulus 0.0037 0.0308 0.0473
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0256 0.2676 0.4728
Loa Loa (eye worm) hypothetical protein 0.0029 0.0213 0.0328
Schistosoma mansoni kinase 0.0041 0.0348 0.1111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0143
Mycobacterium tuberculosis Conserved protein 0.0076 0.0732 0.1407
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0093 0.0298
Schistosoma mansoni hypothetical protein 0.0083 0.08 0.2553
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0011 0.0022 0.0038
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0732 0.1407
Schistosoma mansoni glutaminase 0.0218 0.2272 0.7252
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0213 0.067
Trypanosoma brucei unspecified product 0.0018 0.0103 0.0569
Brugia malayi hydrolase, alpha/beta fold family protein 0.0302 0.3183 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0603 0.1926
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0294 1
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0011 0.0022 0.0022
Echinococcus granulosus tar DNA binding protein 0.0065 0.0603 0.1066
Toxoplasma gondii exonuclease III APE 0.0016 0.0081 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0041 0.0225
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0216 0.0216
Brugia malayi beta-lactamase family protein 0.0076 0.0732 0.2301
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0011 0.0022 0.0068
Trypanosoma brucei unspecified product 0.0013 0.0041 0.0225
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0011 0.0022 0.0069
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0011 0.0022 0.0095
Treponema pallidum exodeoxyribonuclease (exoA) 0.0016 0.0081 0.3756
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0022 0.0095
Treponema pallidum NADH oxidase 0.0029 0.0216 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0213 0.0328
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0135 0.0259
Schistosoma mansoni hypothetical protein 0.0024 0.0161 0.0514
Schistosoma mansoni hypothetical protein 0.0024 0.0161 0.0514
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0011 0.0022 0.0068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.0203
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0135 0.0735
Mycobacterium ulcerans glutaminase 0.0218 0.2272 1
Leishmania major DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0216 0.1292
Mycobacterium tuberculosis Putative ferredoxin reductase 0.019 0.1968 0.3783
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0022 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0603 0.1926
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0143
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0083 0.08 0.2513
Echinococcus multilocularis inhibitor of apoptosis protein 0.0114 0.1145 0.1145
Plasmodium vivax thioredoxin reductase, putative 0.0083 0.0808 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0114 0.1144 0.1757
Leishmania major carbonic anhydrase-like protein 0.0176 0.1813 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0234
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0081 0.0448
Onchocerca volvulus 0.0022 0.0137 0.021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0207
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.1833 0.5759
Echinococcus multilocularis lamin 0.0022 0.0137 0.0137
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0609 0.651 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0163 0.1675 0.3218
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0158
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0093 0.0298
Loa Loa (eye worm) hypothetical protein 0.0029 0.0213 0.0328
Loa Loa (eye worm) inositol-1 0.0036 0.0294 0.0451
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0603 0.1896
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0732 0.3223
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0161 0.0161
Brugia malayi tumor suppressor. 0.0282 0.2959 0.9298
Entamoeba histolytica hypothetical protein 0.006 0.0549 0.7041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0093 0.0293
Plasmodium falciparum glutathione reductase 0.0029 0.0216 0.1858
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0081 0.1043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0143
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0294 0.1621
Onchocerca volvulus 0.0189 0.1956 0.3004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0016 0.0081 0.2765
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0093 0.0143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.026 0.2726 0.8566
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0294 0.1293
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0093 0.0298
Loa Loa (eye worm) hypothetical protein 0.0083 0.08 0.1228
Brugia malayi Calcitonin receptor-like protein seb-1 0.026 0.2726 0.8566
Plasmodium vivax SET domain protein, putative 0.0024 0.0161 0.11
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0137 0.021
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0216 0.0416
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0003 0.0011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0213 0.2736
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0011 0.0022 0.0033
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0083 0.0808 0.1553
Loa Loa (eye worm) glutathione reductase 0.0083 0.0808 0.1241
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0081 0.0448
Onchocerca volvulus 0.0076 0.0732 0.1125
Onchocerca volvulus 0.0011 0.0022 0.0033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.026 0.2726 0.4188
Trypanosoma cruzi polo-like protein kinase, putative 0.0081 0.0779 0.4299
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0016 0.0081 0.1043
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0103 0.0569
Schistosoma mansoni aldehyde dehydrogenase 0.0163 0.1675 0.5345
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0256 0.2676 0.4728
Plasmodium falciparum thioredoxin reductase 0.0029 0.0216 0.1858
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0216 0.0952
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0093 0.0165
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0011 0.0022 0.0038
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0093 0.0093
Brugia malayi Inositol-1 0.0036 0.0294 0.0923
Entamoeba histolytica G protein alpha subunit, putative 0.0011 0.0022 0.0278
Loa Loa (eye worm) glutaminase 0.0218 0.2272 0.349
Schistosoma mansoni hypothetical protein 0.0178 0.1833 0.585
Schistosoma mansoni lamin 0.0022 0.0137 0.0436
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0093 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0093 0.0293
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0114 0.1145 0.3597
Mycobacterium ulcerans hypothetical protein 0.0076 0.0732 0.3223
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0779 0.343
Echinococcus granulosus intermediate filament protein 0.0022 0.0137 0.0241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0093 0.0143
Mycobacterium tuberculosis Conserved protein 0.0076 0.0732 0.1407
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0213 0.067
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0796 0.0796
Loa Loa (eye worm) RNA binding protein 0.0065 0.0603 0.0927
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0003 0.0003
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0011 0.0022 0.0069
Echinococcus multilocularis neuropeptide receptor A26 0.0531 0.5661 0.5661
Echinococcus granulosus neuropeptide s receptor 0.0531 0.5661 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0603 0.0927
Onchocerca volvulus 0.0018 0.0093 0.0143
Echinococcus granulosus dna polymerase eta 0.0018 0.0103 0.0182
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0083 0.08 0.2513
Loa Loa (eye worm) carbonic anhydrase 3 0.0176 0.1813 0.2784
Plasmodium falciparum glutathione reductase 0.0083 0.0808 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0216 0.1194
Echinococcus granulosus hypothetical protein 0.0024 0.0161 0.0285
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Brugia malayi nuclear receptor NHR-88 0.0018 0.0093 0.0293
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0093 0.0093
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0212 0.2199 0.4226
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0093 0.0093
Giardia lamblia DINP protein human, muc B family 0.0018 0.0103 0.1323
Mycobacterium ulcerans aldehyde dehydrogenase 0.0163 0.1675 0.7371
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0256 0.2676 0.4111
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0083 0.08 0.2513
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0213 0.0939
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0011 0.0022 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0732 0.2337
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0256 0.2676 0.2676
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0093 0.0143
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0176 0.1813 0.5695
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0161 0.0515
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0083 0.08 0.1228
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0213 0.0939
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0081 0.0358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0093 0.0143
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0216 0.1194
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0011 0.0022 0.0068
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0024 0.0161 0.0161
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0161 0.0515
Echinococcus granulosus dna polymerase kappa 0.0018 0.0103 0.0182
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0081 0.0448
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0103 0.0324
Onchocerca volvulus Huntingtin homolog 0.0141 0.1428 0.2194
Echinococcus granulosus neuropeptide receptor A26 0.0531 0.5661 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0294 0.0938
Schistosoma mansoni intermediate filament proteins 0.0022 0.0137 0.0436
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0011 0.0022 0.0068
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0103 0.0454
Echinococcus multilocularis dna polymerase eta 0.0018 0.0103 0.0103
Schistosoma mansoni transcription factor LCR-F1 0.006 0.0549 0.1751
Schistosoma mansoni hypothetical protein 0.0082 0.0796 0.2541
Loa Loa (eye worm) tumor suppressor 0.0282 0.2959 0.4546
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0103 0.0569
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0011 0.0022 0.0022
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0081 0.0448
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0176 0.1813 0.5785
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0796 0.2501
Echinococcus granulosus carbonic anhydrase II 0.0176 0.1813 0.3202
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0093 0.0298
Trichomonas vaginalis CAMK family protein kinase 0.0081 0.0779 0.343
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0041 0.0225
Echinococcus granulosus expressed protein 0.0011 0.0022 0.0038
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0081 0.0081
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0135 0.0593
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0081 0.0125
Loa Loa (eye worm) beta-lactamase 0.0076 0.0732 0.1125
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.021
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0093 0.0293
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0213 0.041
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0081 0.0144
Trypanosoma cruzi polo-like protein kinase, putative 0.0081 0.0779 0.4299
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0114 0.1145 0.3597
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0256 0.2676 0.8408
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0163 0.1675 0.9239
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0216 0.068
Loa Loa (eye worm) hypothetical protein 0.0024 0.0161 0.0248
Toxoplasma gondii aldehyde dehydrogenase 0.0163 0.1675 1
Echinococcus granulosus geminin 0.0298 0.3133 0.5535
Echinococcus multilocularis protein quaking 0.0024 0.0161 0.0161
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0294 0.377
Schistosoma mansoni hypothetical protein 0.0082 0.0796 0.2541
Schistosoma mansoni hypothetical protein 0.0114 0.1145 0.3654
Leishmania major DNA polymerase eta, putative 0.0018 0.0103 0.0569
Trichomonas vaginalis esterase, putative 0.0076 0.0732 0.3223
Schistosoma mansoni carbonic anhydrase-related 0.0083 0.08 0.2553
Schistosoma mansoni caspase-7 (C14 family) 0.0037 0.0308 0.0982
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0213 0.1176
Plasmodium vivax glutathione reductase, putative 0.0083 0.0808 1
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0732 0.1407
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0137 0.021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0216 0.1194
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.019 0.1968 0.8952
Onchocerca volvulus Deterin homolog 0.0114 0.1145 0.1759
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.006 0.0549 0.0549
Entamoeba histolytica hypothetical protein 0.006 0.0549 0.7041
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0011 0.0022 0.0095
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0732 0.1407
Brugia malayi serine/threonine-protein kinase plk-2 0.0081 0.0779 0.2449
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0216 0.0382
Loa Loa (eye worm) hypothetical protein 0.0076 0.0732 0.1125
Echinococcus multilocularis carbonic anhydrase 0.0083 0.08 0.08
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0011 0.0022 0.0033
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0294 0.0519
Onchocerca volvulus Huntingtin homolog 0.0141 0.1428 0.2194
Mycobacterium leprae Probable lipase LipE 0.0076 0.0732 0.333
Loa Loa (eye worm) hypothetical protein 0.0083 0.08 0.1228
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0216 0.1194
Schistosoma mansoni carbonic anhydrase-related 0.0083 0.08 0.2553
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0216 0.1194
Brugia malayi cytoplasmic intermediate filament protein 0.0012 0.0028 0.0088

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 195 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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