Detailed information for compound 1271190

Basic information

Technical information
  • TDR Targets ID: 1271190
  • Name: EU-0047453
  • MW: 545.653 | Formula: C29H31N5O4S
  • H donors: 2 H acceptors: 5 LogP: 3.83 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN(C(=O)c1ccc(cc1)Nc1nnc(c2c1cccc2)c1ccc(c(c1)S(=O)(=O)NCC1CCCO1)C)C
  • InChi: 1S/C29H31N5O4S/c1-19-10-11-21(17-26(19)39(36,37)30-18-23-7-6-16-38-23)27-24-8-4-5-9-25(24)28(33-32-27)31-22-14-12-20(13-15-22)29(35)34(2)3/h4-5,8-15,17,23,30H,6-7,16,18H2,1-3H3,(H,31,33)
  • InChiKey: SANAWFBGMBPJFG-UHFFFAOYSA-N  


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Synonyms

  • MLS000590557
  • N,N-dimethyl-4-[[4-[4-methyl-3-(oxolan-2-ylmethylsulfamoyl)phenyl]phthalazin-1-yl]amino]benzamide
  • N,N-dimethyl-4-[[4-[4-methyl-3-(tetrahydrofuran-2-ylmethylsulfamoyl)phenyl]phthalazin-1-yl]amino]benzamide
  • N,N-dimethyl-4-[[4-[4-methyl-3-(2-tetrahydrofuranylmethylsulfamoyl)phenyl]-1-phthalazinyl]amino]benzamide
  • N,N-dimethyl-4-[[4-[4-methyl-3-(tetrahydrofurfurylsulfamoyl)phenyl]phthalazin-1-yl]amino]benzamide
  • N,N-Dimethyl-4-(4-{4-methyl-3-[(tetrahydro-furan-2-ylmethyl)-sulfamoyl]-phenyl}-phthalazin-1-ylamino)-benzamide
  • SMR000217580
  • STK080097

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0003 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0122
Onchocerca volvulus 0.0013 0.0007 0.0152
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0005 0.0113
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0033 0.0795
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0016
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0013 0.0007 0.018
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0024 0.0021
Echinococcus multilocularis tyrosine kinase 0.0013 0.0007 0.018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0016
Mycobacterium ulcerans hypothetical protein 0.0029 0.0024 0.0021
Loa Loa (eye worm) glutamate receptor 0.0134 0.0132 0.5233
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0003 0.0111
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0288 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0063 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0037 0.1449
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0007 0.0002 0.005
Echinococcus granulosus receptor type guanylyl cyclase 0.0013 0.0007 0.018
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0003 0.0668
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.006 0.0056 0.2222
Echinococcus granulosus tyrosine kinase 0.0013 0.0007 0.018
Onchocerca volvulus 0.006 0.0056 0.1843
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.9771 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0648
Entamoeba histolytica hypothetical protein 0.0013 0.0007 0.2096
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0046 0.154
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0024 0.5158
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0013 0.0007 0.0294
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.0942
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0013 0.0007 0.018
Onchocerca volvulus Poor gastrulation protein homolog 0.0022 0.0017 0.0482
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.0113
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0007 0.0165
Brugia malayi MH2 domain containing protein 0.0008 0.0003 0.0111
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0024 0.0942
Schistosoma mansoni Smad4 0.0008 0.0003 0.0138
Onchocerca volvulus 0.0013 0.0007 0.0152
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0003 0.1882
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.003 0.1187
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0016
Brugia malayi Pre-SET motif family protein 0.0037 0.0032 0.1273
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0024 0.5158
Echinococcus granulosus metabotropic glutamate receptor 5 0.0166 0.0164 0.3978
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0003 0.0075
Trypanosoma brucei protein kinase, putative 0.005 0.0046 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0014 0.0339
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0032 0.078
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0553
Echinococcus multilocularis glutamate receptor 2 0.0013 0.0007 0.018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0032 0.1577
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.1449
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0253 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.0179 0.4346
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0113 0.011 0.2664
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0032 0.1577
Loa Loa (eye worm) hypothetical protein 0.018 0.0179 0.7094
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0024 0.0021
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0002 0.0101
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0024 1
Echinococcus granulosus atrial natriuretic peptide receptor 0.0013 0.0007 0.018
Loa Loa (eye worm) RGC/RGC protein kinase 0.0013 0.0007 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0016
Echinococcus granulosus metabotropic glutamate receptor 2 0.0113 0.011 0.2664
Echinococcus granulosus glutamate receptor 2 0.0013 0.0007 0.018
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0006 0.0135
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0007 0.0002 0.005
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0294
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.003 0.0986
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0014 0.0339
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0006 0.0273
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0005 0.0228
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0014 0.0339
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0013 0.0007 0.018
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.0002 0.005
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0006 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0122
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0122
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0032 0.078
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0014 0.0339
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0046 0.2261
Loa Loa (eye worm) hypothetical protein 0.018 0.0179 0.7094
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0013 0.0007 0.018
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0003 0.0001
Echinococcus multilocularis receptor type guanylyl cyclase 0.0013 0.0007 0.018
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0024 0.5158
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0046 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0071 0.3488
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0046 0.1119
Brugia malayi MH1 domain containing protein 0.0008 0.0003 0.0111
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0056 0.2222
Echinococcus multilocularis smad 0.0008 0.0003 0.0068
Plasmodium vivax SET domain protein, putative 0.0037 0.0032 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0003 0.0122
Echinococcus multilocularis geminin 0.0205 0.0204 0.4948
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0024 0.0021
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0003 0.0668
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0051 0.2502
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0051 0.1238
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0294
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0034 0.003 0.1179
Echinococcus multilocularis muscleblind protein 0.018 0.0179 0.4346
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.003 0.0728
Schistosoma mansoni 60S ribosomal protein L21 0.0006 0.0001 0.0025
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0003 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0013
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.0002 0.005
Loa Loa (eye worm) glutamate receptor 0.0053 0.0049 0.1926
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0032 0.5096
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0024 0.0021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0024 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0056 0.2222
Mycobacterium ulcerans AcrR family transcriptional regulator 0.9771 1 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0046 0.154
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0013 0.0007 0.0294
Loa Loa (eye worm) RGC/RGC protein kinase 0.0013 0.0007 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0016
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0046 0.1826
Echinococcus granulosus smad 0.0008 0.0003 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0003 0.0001
Echinococcus granulosus GPCR family 2 0.0019 0.0014 0.0339
Trypanosoma cruzi extracellular receptor, putative 0.0013 0.0007 0.1008
Echinococcus granulosus Smad4 0.0008 0.0003 0.0068
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0685
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0006 0.0135
Echinococcus granulosus geminin 0.0205 0.0204 0.4948
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0016
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0007 0.027
Schistosoma mansoni cpg binding protein 0.0037 0.0032 0.1569
Onchocerca volvulus 0.0287 0.0288 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.0002 0.005
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0234 0.9271
Loa Loa (eye worm) hypothetical protein 0.0123 0.012 0.4749
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.0002 0.0101
Brugia malayi metabotropic glutamate receptor type 2 0.0066 0.0062 0.2438
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0081
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0046 1
Echinococcus granulosus glutamate receptor 2 0.0013 0.0007 0.018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0024 0.0022
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0022 0.0017 0.0482
Echinococcus granulosus cpg binding protein 0.0037 0.0032 0.0776
Brugia malayi CXXC zinc finger family protein 0.0035 0.003 0.1187
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0032 0.078
Brugia malayi MAP kinase sur-1 0.005 0.0046 0.1826
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0007 0.0002 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0032 0.1577
Brugia malayi Receptor family ligand binding region containing protein 0.0013 0.0007 0.0294
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0013 0.0007 0.0152
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.0036
Echinococcus multilocularis cpg binding protein 0.0037 0.0032 0.0776
Brugia malayi Guanylyl cyclase protein 23 0.0013 0.0007 0.0294
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.0002 0.005
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0013 0.0007 0.018
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0033 0.1297
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0051 0.1238
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0016
Echinococcus multilocularis glutamate receptor 2 0.0013 0.0007 0.018
Mycobacterium ulcerans transcriptional regulator 0.9771 1 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.012 0.4749
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0001 0.0045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0007 0.0165
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0003 0.0488
Brugia malayi MH1 domain containing protein 0.0008 0.0003 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0016
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0117 0.4623
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0056 0.2727
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0046 0.7309
Echinococcus granulosus nmda type glutamate receptor 0.0013 0.0007 0.018
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.003 0.0986
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0122
Echinococcus granulosus muscleblind protein 0.018 0.0179 0.4346
Onchocerca volvulus 0.0035 0.003 0.0944
Schistosoma mansoni protein kinase 0.0013 0.0007 0.0364
Loa Loa (eye worm) hypothetical protein 0.0166 0.0164 0.6492
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0024 0.0942
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0685
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0003 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0051 0.1238
Brugia malayi Muscleblind-like protein 0.018 0.0179 0.7094
Onchocerca volvulus 0.0037 0.0032 0.102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0016
Schistosoma mansoni metabotropic glutamate receptor 0.0113 0.011 0.5384
Schistosoma mansoni smad1 5 8 and 0.0008 0.0003 0.0138
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0003 0.0488
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0013 0.0007 0.018
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0016 0.0013
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0003 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0003 0.0111
Echinococcus multilocularis nmda type glutamate receptor 0.0013 0.0007 0.018
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0003 0.0488
Echinococcus multilocularis tumor protein p63 0.0408 0.0412 1
Leishmania major extracellular receptor, putative 0.0013 0.0007 0.1609
Mycobacterium ulcerans TetR family transcriptional regulator 0.9771 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.0942
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0024 0.0021
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.0002 0.005
Brugia malayi Pre-SET motif family protein 0.0252 0.0253 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0051 0.202
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0034 0.003 0.1179
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0007 0.0002 0.005
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0016 0.4573
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0016
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0122 0.0119 0.472
Schistosoma mansoni smad1 5 8 and 0.0008 0.0003 0.0138
Loa Loa (eye worm) hypothetical protein 0.006 0.0056 0.2202
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0003 0.0668
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.0942
Onchocerca volvulus Huntingtin homolog 0.0123 0.012 0.41
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0056 0.2222
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0003 0.0001
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0022 0.0017 0.0666
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0051 0.1238
Echinococcus multilocularis GPCR, family 3, C terminal 0.0022 0.0017 0.0408
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0033 0.0795
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0648
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0013 0.0007 0.018
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0002 0.0101
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0046 1
Schistosoma mansoni glutamate receptor NMDA 0.0013 0.0007 0.0364
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0013 0.0007 0.018
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0003 0.0001
Brugia malayi Smad1 0.0008 0.0003 0.0111
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0294
Echinococcus granulosus GPCR family 3 C terminal 0.0022 0.0017 0.0408
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0294
Schistosoma mansoni hypothetical protein 0.0205 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0648
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0046 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0046 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0024 0.0021
Schistosoma mansoni hypothetical protein 0.0022 0.0017 0.0825
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0046 0.1119
Brugia malayi Metabotropic glutamate receptor precursor. 0.0134 0.0132 0.5233
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0016
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0003 0.0001
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0153 0.0151 0.7404
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0122
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0006 0.0135
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0006 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0648
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0294
Brugia malayi hypothetical protein 0.0013 0.0007 0.0294
Schistosoma mansoni smad1 5 8 and 0.0008 0.0003 0.0138
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0122
Loa Loa (eye worm) RGC/RGC protein kinase 0.0013 0.0007 0.0294
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0005 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0648
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.0002 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0032 0.1577
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0013 0.0007 0.018
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0046 0.1119
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0014 0.0339
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0003 0.0001
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0003 0.0068
Brugia malayi Cyclic-nucleotide gated cation channel 0.0007 0.0002 0.0081
Schistosoma mansoni cpg binding protein 0.0035 0.003 0.147
Loa Loa (eye worm) Smad1 0.0008 0.0003 0.0111
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0024 0.0022
Onchocerca volvulus 0.0029 0.0024 0.0726
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0166 0.0164 0.3978
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0046 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0032 0.1273
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0046 0.154
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0117 0.4623
Brugia malayi Receptor family ligand binding region containing protein 0.0034 0.003 0.1179
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0007 0.0264
Brugia malayi MH2 domain containing protein 0.0008 0.0003 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0046 0.154
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0046 1
Schistosoma mansoni smad 0.0008 0.0003 0.0138
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0003 0.0068
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0024 0.0021
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0234 0.9271
Brugia malayi MH2 domain containing protein 0.0119 0.0117 0.4623
Schistosoma mansoni voltage-gated potassium channel 0.0006 0.0001 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0051 0.202
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0036 0.1779
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0666
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0003 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0014 0.0553
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.0002 0.005
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0003 0.0122
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.1097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0051 0.2502
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0003 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0024 0.0942
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0007 0.0002 0.005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0294
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.1795
Schistosoma mansoni metabotropic glutamate receptor 0.0066 0.0062 0.3019
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0122
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0036 0.1779
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0221
Trichomonas vaginalis helicase, putative 0.0008 0.0003 0.0016
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0003 0.0138
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0024 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0051 0.2502
Schistosoma mansoni cpg binding protein 0.0037 0.0032 0.1569
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0046 0.1119
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0014 0.0553
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0122
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0685
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0014 0.0553
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0003 0.0068
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0016 0.5
Brugia malayi hypothetical protein 0.0123 0.012 0.4749
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0033 0.1297
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0024 0.0021
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0016 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.0002 0.0081
Schistosoma mansoni tyrosine kinase 0.0013 0.0007 0.0364
Echinococcus granulosus tumor protein p63 0.0408 0.0412 1
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0002 0.0101
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0046 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0002 0.0101
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0685
Echinococcus multilocularis Smad4 0.0008 0.0003 0.0068
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0003 0.0068
Loa Loa (eye worm) hypothetical protein 0.0034 0.003 0.1179
Onchocerca volvulus Huntingtin homolog 0.0123 0.012 0.41
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0006 0.0221
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0024 0.0021
Schistosoma mansoni hypothetical protein 0.0205 0.0204 1
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0003 0.0151
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.0002 0.0101
Schistosoma mansoni tyrosine kinase 0.0013 0.0007 0.0364
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0113

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 10.691 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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