Detailed information for compound 1282898

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 420.891 | Formula: C23H21ClN4O2
  • H donors: 1 H acceptors: 4 LogP: 4.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Cc1c(C)nc2n(c1O)ncc2C(=O)N(Cc1ccccc1)C
  • InChi: 1S/C23H21ClN4O2/c1-15-19(12-16-8-10-18(24)11-9-16)23(30)28-21(26-15)20(13-25-28)22(29)27(2)14-17-6-4-3-5-7-17/h3-11,13,30H,12,14H2,1-2H3
  • InChiKey: YAKGDNYTXXMYAC-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0219 1
Brugia malayi MH1 domain containing protein 0.0075 0.0159 0.0171
Entamoeba histolytica hypothetical protein 0.0257 0.0704 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.007 0.0687
Schistosoma mansoni CD36-like class B scavenger receptor 0.1641 0.4836 0.8439
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.008 0.0059
Brugia malayi hypothetical protein 0.0257 0.0704 0.0844
Echinococcus multilocularis CD36 class B scavenger receptor 0.1641 0.4836 0.4825
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.008 0.0099
Echinococcus multilocularis isocitrate dehydrogenase 0.0049 0.0083 0.0062
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0117 0.3371
Echinococcus granulosus CD36 class B scavenger receptor 0.1641 0.4836 0.8439
Brugia malayi 'Paired box' domain containing protein 0.0053 0.0093 0.0089
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0083 0.2064
Echinococcus granulosus GPCR family 2 0.0152 0.0389 0.0645
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0117 0.0097
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0022 0.4217
Loa Loa (eye worm) hypothetical protein 0.0053 0.0093 0.0114
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0214 0.0194
Schistosoma mansoni hypothetical protein 0.0152 0.0389 0.0645
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0083 0.0062
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0106
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0219 0.0348
Giardia lamblia DINP protein human, muc B family 0.0039 0.0051 0.1522
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0039 0.0048
Entamoeba histolytica hypothetical protein 0.0257 0.0704 1
Echinococcus granulosus paired box protein pax 6 0.0053 0.0093 0.0126
Brugia malayi paired box protein 0.0053 0.0093 0.0089
Brugia malayi mbt repeat family protein 0.0048 0.008 0.0073
Schistosoma mansoni hypothetical protein 0.0328 0.0915 0.1567
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0049 0.0083 1
Loa Loa (eye worm) nuclear factor I 0.0075 0.0159 0.0196
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0273 0.0752 0.0902
Mycobacterium ulcerans hypothetical protein 0.0029 0.0022 0.4217
Echinococcus multilocularis tumor protein p63 0.0408 0.1154 0.1135
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0083 0.2079
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0051 0.6193
Giardia lamblia Kinase, PLK 0.0095 0.0219 1
Echinococcus multilocularis CD36 class B scavenger receptor 0.1641 0.4836 0.4825
Brugia malayi mbt repeat family protein 0.0048 0.008 0.0073
Loa Loa (eye worm) hypothetical protein 0.0075 0.0159 0.0196
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0273 0.0752 0.0926
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0039 0.0031
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0051 0.0037
Echinococcus multilocularis smad 0.0135 0.034 0.032
Echinococcus multilocularis snurportin 1 0.0648 0.1871 0.1854
Loa Loa (eye worm) MH2 domain-containing protein 0.1986 0.5862 0.7218
Echinococcus multilocularis ubiquitin specific protease 41 0.005 0.0086 0.0065
Schistosoma mansoni ran 0.0045 0.007 0.0085
Loa Loa (eye worm) transcription factor SMAD2 0.1986 0.5862 0.7218
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.005 0.0086 0.2062
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0051 0.1182
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0219 0.6676
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0219 0.027
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0051 0.0053
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0051 0.0434
Schistosoma mansoni hypothetical protein 0.194 0.5726 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0057 0.0044
Schistosoma mansoni DNA polymerase eta 0.0039 0.0051 0.0053
Schistosoma mansoni cd36 antigen 0.062 0.1787 0.3095
Echinococcus multilocularis expressed protein 0.004 0.0057 0.0036
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0051 0.1182
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0051 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0114 0.0164
Loa Loa (eye worm) hypothetical protein 0.0061 0.0117 0.0145
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0051 1
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0039 0.0031
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0083 0.1897
Schistosoma mansoni paired box protein pax-1-related 0.0053 0.0093 0.0126
Echinococcus multilocularis CD36 class B scavenger receptor 0.1641 0.4836 0.4825
Loa Loa (eye worm) MH1 domain-containing protein 0.006 0.0117 0.0144
Trypanosoma brucei polo-like protein kinase 0.0095 0.0219 0.6743
Schistosoma mansoni hypothetical protein 0.0257 0.0704 0.1198
Brugia malayi vab-3 gene. 0.0053 0.0093 0.0089
Loa Loa (eye worm) Smad1 0.0135 0.034 0.0419
Echinococcus multilocularis Smad4 0.0135 0.034 0.032
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0076 0.1493
Echinococcus granulosus CD36 class B scavenger receptor 0.1641 0.4836 0.8439
Schistosoma mansoni smad 0.0135 0.034 0.0559
Loa Loa (eye worm) hypothetical protein 0.1641 0.4836 0.5953
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.007 0.0687
Brugia malayi Isocitrate dehydrogenase 0.0049 0.0083 0.0076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0022 0.2612
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0273 0.0752 0.1281
Brugia malayi jmjC domain containing protein 0.0034 0.0039 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0219 1
Echinococcus multilocularis CD36 class B scavenger receptor 0.1641 0.4836 0.4825
Echinococcus granulosus expressed protein 0.004 0.0057 0.0062
Loa Loa (eye worm) hypothetical protein 0.0049 0.0082 0.0101
Leishmania major DNA polymerase kappa, putative 0.0039 0.0051 0.1
Brugia malayi 'Paired box' domain containing protein 0.0053 0.0093 0.0089
Brugia malayi MH2 domain containing protein 0.1986 0.5862 0.7211
Schistosoma mansoni hypothetical protein 0.0152 0.0389 0.0645
Trichomonas vaginalis rotamase, putative 0.0039 0.0054 0.0147
Schistosoma mansoni Smad4 0.006 0.0117 0.0168
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0054 0.047
Loa Loa (eye worm) hypothetical protein 0.0128 0.0318 0.0391
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0049 0.0083 0.2224
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0083 0.1197
Loa Loa (eye worm) hypothetical protein 0.0055 0.01 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0086 0.2062
Plasmodium falciparum importin beta, putative 0.0061 0.0117 0.3695
Echinococcus granulosus importin subunit beta 1 0.0061 0.0117 0.0169
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0022 0.0001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0648 0.1871 0.2304
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0022 0.5
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.1641 0.4836 0.8439
Onchocerca volvulus 0.006 0.0114 0.0115
Echinococcus granulosus mothers against decapentaplegic 2 0.006 0.0117 0.0168
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.007 0.0049
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0157 0.0238
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.0026
Trypanosoma cruzi PAB1-binding protein , putative 0.0128 0.0318 1
Brugia malayi Importin beta-1 subunit 0.0061 0.0117 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0051 0.1182
Brugia malayi MH1 domain containing protein 0.0135 0.034 0.0394
Loa Loa (eye worm) hypothetical protein 0.0053 0.0093 0.0114
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0051 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0273 0.0752 0.1281
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0135 0.034 0.032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0273 0.0752 0.1281
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0219 0.6307
Echinococcus multilocularis dna polymerase eta 0.0039 0.0051 0.003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0039 0.0031
Loa Loa (eye worm) hypothetical protein 0.006 0.0117 0.0144
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0083 0.0062
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0051 0.1182
Plasmodium falciparum ataxin-2 like protein, putative 0.0128 0.0318 1
Brugia malayi latrophilin 2 splice variant baaae 0.0328 0.0915 0.1104
Echinococcus granulosus jumonji domain containing protein 0.004 0.0054 0.0058
Loa Loa (eye worm) latrophilin receptor protein 2 0.0152 0.0389 0.0479
Brugia malayi jmjC domain containing protein 0.0093 0.0214 0.0238
Loa Loa (eye worm) isocitrate dehydrogenase 0.0049 0.0083 0.0102
Brugia malayi MH2 domain containing protein 0.006 0.0117 0.0118
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.048 0.1368 0.1663
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0152 0.0389 0.0645
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.039 0.037
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0057 0.0316
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.005 0.0086 0.0065
Schistosoma mansoni ran 0.0045 0.007 0.0085
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.007 0.1635
Trypanosoma brucei PAB1-binding protein , putative 0.0128 0.0318 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0051 0.1182
Echinococcus granulosus paired box protein pax 1 0.0053 0.0093 0.0126
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0022 0.5
Loa Loa (eye worm) MH1 domain-containing protein 0.0135 0.034 0.0419
Brugia malayi RNA, U transporter 1 0.0173 0.0452 0.0531
Brugia malayi hypothetical protein 0.062 0.1787 0.2179
Trypanosoma cruzi PAB1-binding protein , putative 0.0128 0.0318 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.005 0.0086 0.2171
Trichomonas vaginalis rotamase, putative 0.004 0.0057 0.0316
Echinococcus multilocularis lysosome membrane protein 2 0.1641 0.4836 0.4825
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0219 0.0245
Schistosoma mansoni hypothetical protein 0.0152 0.0389 0.0645
Loa Loa (eye worm) hypothetical protein 0.0048 0.008 0.0099
Brugia malayi hypothetical protein 0.0128 0.0318 0.0366
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.008 0.0073
Echinococcus granulosus dna polymerase kappa 0.0039 0.0051 0.0053
Schistosoma mansoni hypothetical protein 0.0294 0.0812 0.1387
Echinococcus granulosus CD36 class B scavenger receptor 0.1641 0.4836 0.8439
Loa Loa (eye worm) hypothetical protein 0.062 0.1787 0.22
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0426 0.071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.0063
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0426 0.071
Echinococcus multilocularis GPCR, family 2 0.0152 0.0389 0.0369
Schistosoma mansoni smad 0.006 0.0117 0.0168
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0049 0.0083 0.2603
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0051 0.0053
Plasmodium vivax importin-beta 2, putative 0.0061 0.0117 0.3695
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0083 0.1897
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0083 0.1182
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0054 0.1084
Echinococcus multilocularis paired box protein pax 6 0.0053 0.0093 0.0072
Echinococcus granulosus smad 0.0135 0.034 0.0559
Loa Loa (eye worm) MBCTL1 0.0055 0.01 0.0123
Brugia malayi MH2 domain containing protein 0.0135 0.034 0.0394
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0083 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0051 0.1182
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0051 0.6193
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0219 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.007 0.0086
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.005 0.0086 0.0114
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.005 0.0086 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0022 0.4217
Schistosoma mansoni importin beta-1 0.0061 0.0117 0.0169
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0057 0.0107 0.0086
Schistosoma mansoni hypothetical protein 0.0057 0.0107 0.0151
Leishmania major GTP-binding protein, putative 0.0045 0.007 0.1619
Loa Loa (eye worm) hypothetical protein 0.1641 0.4836 0.5953
Echinococcus multilocularis mothers against decapentaplegic 2 0.006 0.0117 0.0096
Entamoeba histolytica hypothetical protein 0.0257 0.0704 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0022 0.0001
Loa Loa (eye worm) paired box protein 0.0053 0.0093 0.0114
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.01 0.0079
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0049 0.0083 0.0108
Brugia malayi isocitrate dehydrogenase 0.0049 0.0083 0.0076
Echinococcus granulosus paired box protein pax 6 0.0053 0.0093 0.0126
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0051 0.1182
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.005 0.0086 0.327
Brugia malayi MH1 domain containing protein 0.0075 0.0159 0.0171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0152 0.0389 0.0369
Schistosoma mansoni rotamase 0.004 0.0057 0.0062
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.0504 0.0484
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0049 0.0083 0.1182
Schistosoma mansoni transcription factor LCR-F1 0.0257 0.0704 0.1198
Loa Loa (eye worm) pigment dispersing factor receptor c 0.048 0.1368 0.1684
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0219 0.0348
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.005 0.0086 0.2328
Echinococcus multilocularis mothers against decapentaplegic 5 0.0135 0.034 0.032
Brugia malayi mothers against decapentaplegic homolog 3 0.006 0.0117 0.0118
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0039 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.006 0.0117 0.0144
Echinococcus multilocularis mothers against decapentaplegic 6 0.006 0.0117 0.0096
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.005 0.0086 0.0941
Trypanosoma brucei unspecified product 0.0039 0.0051 0.1182
Loa Loa (eye worm) hypothetical protein 0.062 0.1787 0.22
Echinococcus granulosus CD36 class B scavenger receptor 0.1641 0.4836 0.8439
Echinococcus granulosus mothers against decapentaplegic 5 0.0135 0.034 0.0559
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0022 0.4217
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0027
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0021 0.0026
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0219 0.0199
Echinococcus granulosus paired box gene 3/7 (eyeless, eyegone, twin of eyeless) 0.0053 0.0093 0.0126
Trichomonas vaginalis ran, putative 0.0045 0.007 0.109
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.005 0.0086 0.0114
Brugia malayi hypothetical protein 0.062 0.1787 0.2179
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0051 0.003
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0057 0.0107 0.0151
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.007 0.2189
Plasmodium vivax ataxin-2 like protein, putative 0.0128 0.0318 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0111 0.0137
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.01 0.0139
Onchocerca volvulus Mothers against decapentaplegic homolog 0.006 0.0117 0.0118
Schistosoma mansoni hypothetical protein 0.0152 0.039 0.0647
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.039 0.0647
Brugia malayi Latrophilin receptor protein 2 0.0152 0.0389 0.0454
Echinococcus granulosus CD36 class B scavenger receptor 0.1641 0.4836 0.8439
Echinococcus granulosus geminin 0.194 0.5726 1
Schistosoma mansoni smad1 5 8 and 0.0135 0.034 0.0559
Schistosoma mansoni Smad4 0.006 0.0117 0.0168
Onchocerca volvulus Retinal homeobox protein Rx homolog 0.0053 0.0093 0.0089
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0054 0.1264
Echinococcus multilocularis paired box protein pax 6 0.0053 0.0093 0.0072
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0214 0.0339
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0022 0.2612
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.005 0.0086 0.0114
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.005 0.0086 0.13
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0049 0.0083 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0022 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0219 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.034 0.0419
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0219 0.2895
Echinococcus multilocularis CD36 class B scavenger receptor 0.1641 0.4836 0.4825
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0049 0.0083 0.2603
Leishmania major importin beta-1 subunit, putative 0.0049 0.0083 0.2077
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.008 0.0059
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0135 0.034 0.0559
Loa Loa (eye worm) vab-3 0.0053 0.0093 0.0114
Brugia malayi N-terminal motif family protein 0.0371 0.1042 0.126
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0022 0.4217
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.0426 0.0406
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0219 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.01 0.0139
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.01 0.0098
Toxoplasma gondii LsmAD domain-containing protein 0.0128 0.0318 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0371 0.1042 0.126
Loa Loa (eye worm) pax transcription factor protein 2 0.2743 0.8122 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0093 0.0114
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0117 0.3248
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.007 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0219 1
Schistosoma mansoni CD36-like class B scavenger receptor 0.1641 0.4836 0.8439
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0051 0.1182
Entamoeba histolytica hypothetical protein 0.0049 0.0083 0.0901
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0083 0.2224
Echinococcus multilocularis geminin 0.194 0.5726 0.5717
Loa Loa (eye worm) hypothetical protein 0.048 0.1368 0.1684
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0152 0.0389 0.0454
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0054 0.0093
Brugia malayi Gooseberry protein 0.0053 0.0093 0.0089
Brugia malayi MH1 domain containing protein 0.0135 0.034 0.0394
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0076 0.1493
Schistosoma mansoni paired box protein pax-6 0.0053 0.0093 0.0126
Onchocerca volvulus 0.0048 0.008 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0051 0.1182
Echinococcus multilocularis paired box protein pax 6 0.0053 0.0093 0.0072
Echinococcus granulosus ubiquitin specific protease 41 0.005 0.0086 0.0114
Brugia malayi 'Paired box' domain containing protein 0.0053 0.0093 0.0089
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0054 0.1101
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0219 0.0245
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.008 0.0104
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0054 0.0093
Schistosoma mansoni paired box protein pax-6 0.0053 0.0093 0.0126
Brugia malayi Pax transcription factor protein 2 0.2743 0.8122 1
Schistosoma mansoni hypothetical protein 0.0648 0.1871 0.3243
Leishmania major DNA polymerase eta, putative 0.0039 0.0051 0.1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0273 0.0752 0.0732
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.008 0.0104
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.008 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0021 0.0662
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.008 0.0104
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.062 0.1787 0.22
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.008 0.0104
Loa Loa (eye worm) hypothetical protein 0.0371 0.1042 0.1283
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.005 0.0086 0.2062
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0057 0.007
Echinococcus multilocularis paired box protein pax 1 0.0053 0.0093 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0051 0.1182
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0051 0.1182
Onchocerca volvulus 0.0053 0.0093 0.0089
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.005 0.0086 0.13
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.007 0.2189
Loa Loa (eye worm) hypothetical protein 0.0152 0.0389 0.0479
Schistosoma mansoni smad1 5 8 and 0.0135 0.034 0.0559
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0257 0.0704 0.0685
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0051 0.0053
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0 0.5
Plasmodium falciparum phd finger protein, putative 0.0028 0.0021 0.0662
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0022 0.4217
Schistosoma mansoni Smad4 0.0135 0.034 0.0559
Schistosoma mansoni paired box protein pax-6 0.0053 0.0093 0.0126
Entamoeba histolytica hypothetical protein 0.0257 0.0704 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0093 0.0114
Brugia malayi CD36 family protein 0.1641 0.4836 0.5943
Echinococcus granulosus snurportin 1 0.0648 0.1871 0.3243
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0051 0.0063
Brugia malayi Calcitonin receptor-like protein seb-1 0.048 0.1368 0.1663
Echinococcus granulosus dna polymerase eta 0.0039 0.0051 0.0053
Schistosoma mansoni hypothetical protein 0.0152 0.0389 0.0645
Brugia malayi hypothetical protein 0.0083 0.0182 0.0199
Echinococcus granulosus TGF beta signal transducer SmadC 0.0135 0.034 0.0559
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0152 0.0389 0.0645
Plasmodium falciparum ataxin-2 like protein, putative 0.0128 0.0318 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.007 0.1788
Brugia malayi paired box pox-meso protein 0.0053 0.0093 0.0089
Echinococcus granulosus mothers against decapentaplegic 6 0.006 0.0117 0.0168
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0051 0.0037
Loa Loa (eye worm) hypothetical protein 0.006 0.0114 0.0141
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.007 0.006
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.005 0.0086 0.008
Loa Loa (eye worm) hypothetical protein 0.1641 0.4836 0.5953
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0051 0.1182
Schistosoma mansoni hypothetical protein 0.194 0.5726 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0051 0.1182
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0152 0.0389 0.0369
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.005 0.0086 0.0065
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.0504 0.0847
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.01 0.0139
Onchocerca volvulus 0.0053 0.0093 0.0089
Loa Loa (eye worm) hypothetical protein 0.0328 0.0915 0.1127
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0022 0.4217
Onchocerca volvulus 0.2743 0.8122 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0049 0.0083 0.0108
Entamoeba histolytica Ran family GTPase 0.0045 0.007 0.0702
Schistosoma mansoni kinase 0.0048 0.008 0.0103
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0257 0.0704 0.1198
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.007 0.2446
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0051 0.1182
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0117 0.3371
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0273 0.0752 0.1281
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0051 0.1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0022 0.4217
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0219 1
Leishmania major hypothetical protein, conserved 0.0128 0.0318 1
Brugia malayi Smad1 0.0135 0.034 0.0394
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0054 0.0033
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.1641 0.4836 0.5943
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0219 0.6307
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0083 0.2079
Echinococcus granulosus tumor protein p63 0.0408 0.1154 0.1986
Schistosoma mansoni smad1 5 8 and 0.0135 0.034 0.0559
Brugia malayi MH2 domain containing protein 0.0135 0.034 0.0394
Echinococcus granulosus lysosome membrane protein 2 0.1641 0.4836 0.8439
Echinococcus granulosus Smad4 0.0135 0.034 0.0559
Onchocerca volvulus 0.0029 0.0022 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0083 0.1897
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0273 0.0752 0.0732
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0273 0.0752 0.1281
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.01 0.0079

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0282 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (binding) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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