Detailed information for compound 1289651

Basic information

Technical information
  • TDR Targets ID: 1289651
  • Name: 2,5,8-trihydroxy-6-methoxy-2-methyl-3H-benzo[ g]chromen-4-one
  • MW: 290.268 | Formula: C15H14O6
  • H donors: 3 H acceptors: 4 LogP: 2.1 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(O)cc2c1c(O)c1c(c2)OC(CC1=O)(C)O
  • InChi: 1S/C15H14O6/c1-15(19)6-9(17)13-11(21-15)4-7-3-8(16)5-10(20-2)12(7)14(13)18/h3-5,16,18-19H,6H2,1-2H3
  • InChiKey: FKCYENFBFZUSDP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3748-39-8
  • ACon0_001049
  • 4H-Naphtho(2,3-b)pyran-4-one, 2,3-dihydro-2,5,8-trihydroxy-6-methoxy-2-methyl-
  • Fonsecin
  • MEGxm0_000042
  • ACon1_002280
  • MLS000863579
  • SMR000440773

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Caenorhabditis elegans Protein GLD-1 Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Protein Rev Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense calpain-like cysteine peptidase, putative,antigen, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi tumor suppressor. Get druggable targets OG5_170288 All targets in OG5_170288
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei hypothetical protein Get druggable targets OG5_130635 All targets in OG5_130635
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum calpain-like cysteine peptidase Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma brucei calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) tumor suppressor Get druggable targets OG5_170288 All targets in OG5_170288
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei variant surface glycoprotein (VSG), putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma congolense calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi calpain cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania donovani hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Leishmania infantum hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1629 1
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0212 0.0212
Echinococcus granulosus dna polymerase kappa 0.0023 0.0082 0.042
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0178 0.0461
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0178 0.0656
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0212 0.0871
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0352 0.1174
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0001 0.0066
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0469
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0438 0.1464
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0438 0.1464
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1074 0.547
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1243 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0305 0.0789
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0001
Brugia malayi Inositol-1 0.0036 0.0212 0.0547
Echinococcus granulosus pyruvate kinase 0.0017 0.0014 0.0071
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.3502 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0305 0.1555
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0076 0.0076
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0167 0.0265
Brugia malayi isocitrate dehydrogenase 0.0015 0.0001 0.0003
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0082 0.0663
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0082 0.004
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.037 0.0956
Loa Loa (eye worm) hypothetical protein 0.0033 0.0178 0.0461
Loa Loa (eye worm) hypothetical protein 0.0107 0.0953 0.2463
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3502 1
Schistosoma mansoni hypothetical protein 0.0033 0.0181 0.0606
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0212 0.1703
Schistosoma mansoni inositol monophosphatase 0.0036 0.0212 0.0707
Plasmodium vivax small ubiquitin-related modifier, putative 0.003 0.0152 0.855
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1603 0.8166
Loa Loa (eye worm) hypothetical protein 0.0023 0.0082 0.0213
Loa Loa (eye worm) hypothetical protein 0.0107 0.0953 0.2463
Chlamydia trachomatis pyruvate kinase 0.0033 0.0178 0.5
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0178 0.0461
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0438 0.0438
Echinococcus multilocularis pyruvate kinase 0.0033 0.0178 0.0178
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0082 0.0499
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0001 0.0009
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0212 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0082 0.0663
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0352 0.0909
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0007 0.0059
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0422 0.1091
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0082 0.0663
Schistosoma mansoni ap endonuclease 0.0023 0.0076 0.0255
Schistosoma mansoni flap endonuclease-1 0.0028 0.0136 0.0453
Toxoplasma gondii small ubiquitin family modifier, putative 0.003 0.0152 0.7201
Echinococcus multilocularis pyruvate kinase 0.0017 0.0014 0.0014
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0178 0.8423
Giardia lamblia Pyruvate kinase 0.0033 0.0178 0.0471
Schistosoma mansoni inositol monophosphatase 0.0036 0.0212 0.0707
Echinococcus multilocularis pyruvate kinase 0.0017 0.0014 0.0014
Trypanosoma brucei hypothetical protein 0.0135 0.1243 1
Schistosoma mansoni patched 1 0.0051 0.037 0.1236
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0082 0.0082
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0001 0.0009
Echinococcus multilocularis pyruvate kinase 0.0033 0.0178 0.0178
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0076 0.0461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0305 0.102
Brugia malayi TAR-binding protein 0.0076 0.0634 0.1639
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0076 0.0614
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0082 0.0499
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0634 0.1639
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0014 0.0657
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1243 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0634 0.2118
Leishmania major pyruvate kinase 0.0033 0.0178 0.1434
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0001 0.0009
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.037 0.1884
Echinococcus granulosus pyruvate kinase 0.0017 0.0014 0.0071
Plasmodium falciparum small ubiquitin-related modifier 0.003 0.0152 0.855
Echinococcus granulosus Protein patched homolog 1 0.0051 0.037 0.1884
Loa Loa (eye worm) hypothetical protein 0.0148 0.1376 0.3555
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0438 0.1132
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0959 0.7716
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.018 0.1712 0.4424
Loa Loa (eye worm) hypothetical protein 0.0049 0.0352 0.0909
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3502 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.1376 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1243 1
Onchocerca volvulus 0.0049 0.0352 0.1448
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0082 0.0018
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0076 0.0179
Entamoeba histolytica protein kinase, putative 0.0108 0.0959 0.2576
Entamoeba histolytica protein kinase, putative 0.0108 0.0959 0.2576
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0167 0.0167
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0212 0.1703
Echinococcus granulosus tar DNA binding protein 0.0076 0.0634 0.323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0305 0.102
Schistosoma mansoni DNA polymerase eta 0.0023 0.0082 0.0275
Trypanosoma brucei small ubiquitin-related modifier 0.003 0.0152 0.1226
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0305 0.0789
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0082 0.0018
Echinococcus granulosus pyruvate kinase 0.0033 0.0178 0.0908
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0167 0.0265
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0001 0.0066
Entamoeba histolytica hypothetical protein 0.0108 0.0959 0.2576
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1243 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Loa Loa (eye worm) inositol-1 0.0036 0.0212 0.0547
Trypanosoma brucei calpain-like protein, putative 0.0135 0.1243 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1629 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0305 0.1555
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1243 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0212 0.0395
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0352 0.1174
Echinococcus granulosus expressed conserved protein 0.0112 0.0999 0.5089
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0076 0.0197
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0082 0.0213
Echinococcus granulosus muscleblind protein 0.018 0.1712 0.8719
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0076 0.428
Giardia lamblia DINP protein human, muc B family 0.0023 0.0082 0.0196
Echinococcus multilocularis muscleblind protein 1 0.018 0.1712 0.1712
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0108 0.0959 0.7716
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0212 0.0395
Schistosoma mansoni hypothetical protein 0.0205 0.1964 0.6558
Echinococcus multilocularis dna polymerase eta 0.0023 0.0082 0.0082
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0167 0.0439
Echinococcus multilocularis dual specificity 0.0108 0.0959 0.0959
Echinococcus multilocularis pyruvate kinase 0.0017 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0007 0.0059
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1336 0.3453
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0007 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0212 0.0395
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0178 0.0461
Brugia malayi mbt repeat family protein 0.0049 0.0352 0.0909
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0178 0.1434
Echinococcus multilocularis muscleblind protein 0.018 0.1712 0.1712
Brugia malayi Flap endonuclease-1 0.0031 0.0167 0.0431
Loa Loa (eye worm) MBCTL1 0.0056 0.0422 0.1091
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0082 0.0663
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0422 0.2151
Brugia malayi Muscleblind-like protein 0.018 0.1712 0.4424
Echinococcus granulosus flap endonuclease 1 0.0031 0.0167 0.085
Brugia malayi Protein kinase domain containing protein 0.0108 0.0959 0.2478
Trypanosoma brucei unspecified product 0.0023 0.0082 0.0663
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0438 0.0438
Echinococcus multilocularis geminin 0.0205 0.1964 0.1964
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1093 0.3651
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0212 0.0396
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0076 0.428
Loa Loa (eye worm) hypothetical protein 0.0051 0.037 0.0956
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0001 0.0055
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1243 1
Brugia malayi hypothetical protein 0.0148 0.1376 0.3555
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.3502 1
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.003 0.0152 0.0509
Loa Loa (eye worm) SMO-1 protein 0.003 0.0152 0.0394
Schistosoma mansoni pyruvate kinase 0.0017 0.0014 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3502 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3502 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0352 0.179
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0352 0.179
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0001 0.0009
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1074 0.2776
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0173 0.1053
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0438 0.1464
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0167 0.0431
Echinococcus multilocularis expressed conserved protein 0.0112 0.0999 0.0999
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0001 0.0003
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1243 1
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0001 0.0055
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1603 0.1603
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3502 1
Brugia malayi RNA binding protein 0.0076 0.0634 0.1639
Loa Loa (eye worm) hypothetical protein 0.0056 0.0422 0.1091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0305 0.0305
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0634 0.1639
Schistosoma mansoni hypothetical protein 0.0049 0.0351 0.1172
Onchocerca volvulus Huntingtin homolog 0.0148 0.1376 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3502 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0167 0.7889
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0082 0.0019
Toxoplasma gondii exonuclease III APE 0.0023 0.0076 0.3604
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0082 0.0275
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1074 0.2913
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0135 0.1243 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1376 0.3555
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0082 0.0275
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0082 0.0213
Echinococcus granulosus pyruvate kinase 0.0017 0.0014 0.0071
Entamoeba histolytica ubiquitin like protein 0.003 0.0152 0.0223
Schistosoma mansoni pyruvate kinase 0.0033 0.0178 0.0595
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0001 0.0001
Leishmania major small ubiquitin protein, putative 0.003 0.0152 0.1226
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0634 0.2118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0197
Giardia lamblia Sentrin 0.003 0.0152 0.0397
Loa Loa (eye worm) hypothetical protein 0.0062 0.0489 0.1264
Loa Loa (eye worm) hypothetical protein 0.0119 0.1074 0.2776
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0212 0.1703
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0001 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.037 0.0857
Schistosoma mansoni hypothetical protein 0.0049 0.0351 0.1172
Brugia malayi jmjC domain containing protein 0.0058 0.0438 0.1132
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0352 0.0352
Schistosoma mansoni hypothetical protein 0.0304 0.2994 1
Trypanosoma brucei unspecified product 0.0016 0.0007 0.0059
Brugia malayi jmjC domain containing protein 0.0058 0.0438 0.1132
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1243 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0422 0.2151
Echinococcus granulosus geminin 0.0205 0.1964 1
Echinococcus multilocularis protein patched 0.0051 0.037 0.037
Schistosoma mansoni hypothetical protein 0.0033 0.0181 0.0606
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1243 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1243 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0076 0.0614
Echinococcus granulosus dna polymerase eta 0.0023 0.0082 0.042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3502 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0152 0.0222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0178 0.0298
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0152 0.1226
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0182 0.0469
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0001 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3502 1
Echinococcus granulosus Small ubiquitin modifier 2 0.003 0.0152 0.0776
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0634 0.2118
Echinococcus granulosus pyruvate kinase 0.0033 0.0178 0.0908
Echinococcus granulosus hypothetical protein 0.0033 0.0181 0.0924
Entamoeba histolytica protein kinase domain containing protein 0.0108 0.0959 0.2576
Brugia malayi tumor suppressor. 0.0388 0.387 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1243 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0076 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0108 0.0959 0.7716
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0076 0.0001
Brugia malayi mbt repeat family protein 0.0049 0.0352 0.0909
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0422 0.0422
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.1902 0.9684
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1336 0.3453
Echinococcus multilocularis protein quaking 0.0033 0.0181 0.0181
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0076 0.0197
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0076 0.0614
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0167 0.1343
Brugia malayi MH2 domain containing protein 0.0144 0.1336 0.3453
Schistosoma mansoni pyruvate kinase 0.0033 0.0178 0.0595
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0178 0.1434
Brugia malayi CHE-14 protein 0.0051 0.037 0.0956
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0178 1
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0959 0.3202
Schistosoma mansoni hypothetical protein 0.0205 0.1964 0.6558
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3502 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0634 0.1639
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0634 0.2118
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0178 0.1434
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0438 0.2232
Brugia malayi hypothetical protein 0.0033 0.0182 0.0469
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0178 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0167 0.1343
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.1902 0.1902
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1074 0.1074
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0178 0.0461
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0014 0.078
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0634 0.2118
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0212 0.1077
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0082 0.0663
Leishmania major DNA polymerase eta, putative 0.0023 0.0082 0.0663
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0167 0.9366
Leishmania major DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Echinococcus granulosus dual specificity 0.0108 0.0959 0.4883
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0305 0.0305
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0108 0.0959 0.2478
Trypanosoma brucei calpain, putative 0.0135 0.1243 1
Echinococcus multilocularis pyruvate kinase 0.0026 0.0107 0.0107
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0178 0.0298
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0422 0.141
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0178 0.0461
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0076 0.0614
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0212 0.1703
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0001
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0014 0.078
Schistosoma mansoni hypothetical protein 0.0049 0.0351 0.1172
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1629 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0082 0.0213
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0082 0.042
Brugia malayi Ubiquitin-like protein SMT3 0.003 0.0152 0.0394
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0634 0.1639
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0135 0.1243 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3502 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0178 0.1087
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Echinococcus multilocularis protein dispatched 1 0.0058 0.0445 0.0445
Leishmania major pyruvate kinase 0.0033 0.0178 0.1434
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0082 0.004
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0001 0.0004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0076 0.0388
Plasmodium falciparum flap endonuclease 1 0.0031 0.0167 0.9366
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0352 0.1174
Plasmodium falciparum pyruvate kinase 0.0033 0.0178 1
Trypanosoma brucei unspecified product 0.0016 0.0007 0.0059
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0352 0.0352
Echinococcus multilocularis Small ubiquitin modifier 2 0.003 0.0152 0.0152
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0082 0.0082
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0082 0.0663
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0305 0.102
Schistosoma mansoni hypothetical protein 0.0049 0.0351 0.1172
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Loa Loa (eye worm) hypothetical protein 0.018 0.1712 0.4424
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0438 0.2232
Schistosoma mansoni ap endonuclease 0.0023 0.0076 0.0255
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0422 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0082 0.0663
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0167 0.1343
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1243 1
Echinococcus granulosus protein quaking 0.0033 0.0181 0.0924
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0178 0.1434
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.037 0.037
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0352 0.1448
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0959 0.7716
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0212 1
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0152 0.1226
Loa Loa (eye worm) tumor suppressor 0.0388 0.387 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1243 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 2.92 uM PUBCHEM_BIOASSAY: MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442] ChEMBL. No reference
IC50 (binding) = 2.957 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2280, AID2290, AID2459] ChEMBL. No reference
IC50 (binding) = 16.241 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2290 (Summary (gld-1 inhibitors)), 2280 (Primary screen (gld-1 inhibitors in singlicate))] ChEMBL. No reference
IC50 (functional) 38.14 uM PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] ChEMBL. No reference
Potency (functional) = 1.2559 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3183 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1705 (qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) ), 2324 (Probe Development Summary of Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1707 (Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay), 2517 (qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1708 (Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV)] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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