Detailed information for compound 1290342

Basic information

Technical information
  • TDR Targets ID: 1290342
  • Name: 2-[[4-amino-6-[(2-methylphenyl)amino]-1,3,5-t riazin-2-yl]methylsulfanyl]-3-butylquinazolin -4-one
  • MW: 447.556 | Formula: C23H25N7OS
  • H donors: 2 H acceptors: 4 LogP: 4.54 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCn1c(SCc2nc(N)nc(n2)Nc2ccccc2C)nc2c(c1=O)cccc2
  • InChi: 1S/C23H25N7OS/c1-3-4-13-30-20(31)16-10-6-8-12-18(16)26-23(30)32-14-19-27-21(24)29-22(28-19)25-17-11-7-5-9-15(17)2/h5-12H,3-4,13-14H2,1-2H3,(H3,24,25,27,28,29)
  • InChiKey: HYSJPKNMAAMTAQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-amino-6-[(2-methylphenyl)amino]-1,3,5-triazin-2-yl]methylsulfanyl]-3-butyl-quinazolin-4-one
  • 2-[[4-amino-6-[(2-methylphenyl)amino]-1,3,5-triazin-2-yl]methylthio]-3-butyl-4-quinazolinone
  • 2-[[4-amino-6-[(2-methylphenyl)amino]-s-triazin-2-yl]methylthio]-3-butyl-quinazolin-4-one
  • ZINC03486950
  • MLS000567406
  • SMR000154064
  • T5332643

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lamin dm0 0.0028 0.0344 0.0839
Leishmania major cathepsin L-like protease 0.0065 0.119 1
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0236 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0138 0.1159
Echinococcus granulosus smad 0.0017 0.0082 0.0185
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0464 0.0678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0464 0.064
Brugia malayi Cathepsin L-like precursor 0.0065 0.119 0.2157
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0236 0.0299
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0042 0.0013
Giardia lamblia DINP protein human, muc B family 0.0019 0.0138 0.0153
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0035 0.0068
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0264 0.1982
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.119 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0447 0.0614
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0065 0.119 0.1159
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0522 0.0984
Schistosoma mansoni cathepsin F (C01 family) 0.0043 0.0695 0.1042
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0438 0.0404
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0464 0.3718
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0464 0.0494
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0138 0.1159
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0074 0.0166
Brugia malayi Cathepsin L-like cysteine proteinase 0.0043 0.0695 0.1233
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0464 0.3718
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0522 0.4391
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0138 0.0192
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0438 0.0617
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.6745 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0522 0.0769
Echinococcus granulosus cathepsin L cysteine proteinase 0.0065 0.119 0.2946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0872 0.1321
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0035 0.0068
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1158 0.1723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.6745 1
Schistosoma mansoni protein kinase 0.0032 0.0437 0.0635
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0065 0.119 0.2946
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0138 0.0325
Brugia malayi RNA binding protein 0.0068 0.1257 0.2283
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0062
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.2122 0.3201
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1158 0.362
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0422 0.0611
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1158 0.2868
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0447 0.3755
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.0036 0.0522 0.0957
Brugia malayi hypothetical protein 0.0128 0.2649 0.4883
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Onchocerca volvulus 0.0065 0.119 0.4417
Schistosoma mansoni smad1 5 8 and 0.0017 0.0082 0.0074
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0543 0.4398
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0944 0.1434
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0138 0.1159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.6745 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2122 0.5269
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0138 0.089
Loa Loa (eye worm) hypothetical protein 0.0043 0.0695 0.1278
Trypanosoma brucei glucose transporter, putative 0.0033 0.0447 0.3755
Brugia malayi MH2 domain containing protein 0.0017 0.0082 0.0087
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0035 0.0051
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0236 0.0317
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0522 0.0957
Loa Loa (eye worm) hypothetical protein 0.0036 0.0522 0.0957
Echinococcus multilocularis lamin 0.0028 0.0344 0.0839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0491 0.1131
Leishmania major cathepsin L-like protease 0.0065 0.119 1
Echinococcus multilocularis musashi 0.0028 0.0344 0.0839
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0586 0.0821
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0586 0.0821
Trypanosoma brucei glucose transporter 1E 0.0033 0.0447 0.3755
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0236 0.0568
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.119 1
Echinococcus granulosus lamin dm0 0.0028 0.0344 0.0839
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0522 0.422
Echinococcus multilocularis cathepsin L 0.0033 0.0464 0.1138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.119 0.1721
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0242
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0585 0.1771
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0138 0.1159
Loa Loa (eye worm) hypothetical protein 0.0052 0.0896 0.1651
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.5389 1
Echinococcus multilocularis solute carrier family 22 0.0015 0.0035 0.0068
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0437 0.1071
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0944 0.2332
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.6745 0.5
Plasmodium vivax unspecified product 0.0021 0.0188 0.0154
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0522 0.0726
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0437 0.0635
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0586 0.1441
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.6745 1
Brugia malayi mbt repeat family protein 0.0047 0.0792 0.1413
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.017 0.3618 0.3595
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Plasmodium vivax unspecified product 0.0033 0.0464 0.0431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0586 0.087
Mycobacterium ulcerans lipase LipD 0.0036 0.0522 0.157
Brugia malayi hypothetical protein 0.0025 0.0264 0.0427
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0586 0.4769
Echinococcus granulosus cysteine protease 0.0033 0.0464 0.1138
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0065 0.119 0.2946
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0264 0.0351
Echinococcus granulosus solute carrier family 22 0.0015 0.0035 0.0068
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0447 0.3565
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0872 0.1321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0792 0.2894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2122 0.5269
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1158 0.9729
Onchocerca volvulus 0.0065 0.119 0.4417
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0437 0.1071
Echinococcus granulosus intermediate filament protein 0.0028 0.0344 0.0839
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0585 0.1438
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0236 0.0308
Schistosoma mansoni inositol monophosphatase 0.0039 0.0585 0.0868
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0944 0.2332
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.119 0.1721
Loa Loa (eye worm) hypothetical protein 0.0043 0.0695 0.1278
Plasmodium vivax vivapain-2 0.0065 0.119 0.1159
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0944 0.2332
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0082 0.0138
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0522 0.0984
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0035 0.0068
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.119 0.1592
Brugia malayi cathepsin L-like precursor 0.0043 0.0695 0.1233
Trypanosoma brucei glucose transporter, putative 0.0033 0.0447 0.3755
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0872 0.2154
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1158 0.1774
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0522 0.157
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0437 0.0599
Entamoeba histolytica protein kinase, putative 0.0032 0.0437 0.0453
Loa Loa (eye worm) hypothetical protein 0.0028 0.0344 0.0626
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0522 0.0984
Echinococcus granulosus Smad4 0.0017 0.0082 0.0185
Leishmania major cathepsin L-like protease 0.0065 0.119 1
Schistosoma mansoni protein kinase 0.0032 0.0437 0.0635
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0586 0.1441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.119 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.1257 0.2323
Toxoplasma gondii protein kinase, putative 0.0297 0.6554 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0082 0.0074
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1257 0.193
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0138 0.1159
Leishmania major glucose transporter, lmgt2 0.0033 0.0447 0.3565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.119 0.1721
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0138 0.0242
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0585 0.0843
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0437 0.1071
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0437 0.3675
Schistosoma mansoni hypothetical protein 0.0289 0.6368 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0065 0.119 0.2946
Loa Loa (eye worm) hypothetical protein 0.0032 0.0437 0.0798
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0169 0.0199
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0522 0.157
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0344 0.0577
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0872 0.2154
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0264 0.023
Echinococcus multilocularis smad 0.0017 0.0082 0.0185
Loa Loa (eye worm) hypothetical protein 0.0128 0.2649 0.4909
Trypanosoma brucei glucose transporter, putative 0.0033 0.0447 0.3755
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0586 0.087
Loa Loa (eye worm) hypothetical protein 0.0036 0.0516 0.0944
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0437 0.0798
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0585 0.476
Trypanosoma brucei glucose transporter, putative 0.0033 0.0447 0.3755
Loa Loa (eye worm) Smad1 0.0017 0.0082 0.0138
Plasmodium falciparum protein kinase 7 0.0297 0.6554 0.6542
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0792 0.1954
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0264 0.023
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0438 0.0404
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0447 0.0614
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0464 0.0802
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0522 0.0726
Echinococcus granulosus tar DNA binding protein 0.0068 0.1257 0.3115
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2122 0.5269
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.5281 0.98
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.6745 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0522 0.0726
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0236 0.0646
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0065 0.119 0.1721
Brugia malayi Cathepsin L-like precursor 0.0065 0.119 0.2157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0138 0.089
Entamoeba histolytica cysteine protease, putative 0.0065 0.119 0.1592
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0138 0.089
Plasmodium vivax vivapain-3 0.0033 0.0464 0.0431
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0437 0.0798
Leishmania major glucose transporter, lmgt3 0.0033 0.0447 0.3565
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0138 0.089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0422 0.043
Loa Loa (eye worm) beta-lactamase 0.0036 0.0522 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0695 0.0984
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0464 0.064
Loa Loa (eye worm) hypothetical protein 0.0021 0.0188 0.0336
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0896 0.1609
Plasmodium vivax vivapain-2 0.0065 0.119 0.1159
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0082 0.0185
Echinococcus multilocularis cathepsin L cysteine protease 0.0065 0.119 0.2946
Plasmodium vivax vivapain-1 0.0033 0.0464 0.0431
Trypanosoma cruzi hexose transporter 0.0033 0.0447 0.3565
Entamoeba histolytica cysteine proteinase 2 0.0033 0.0464 0.0494
Brugia malayi follicle stimulating hormone receptor 0.0242 0.5281 0.9799
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.402 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0522 0.1235
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0105 0.0608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.119 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0543 0.4398
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0437 0.1071
Loa Loa (eye worm) MBCTL1 0.0054 0.0944 0.1739
Loa Loa (eye worm) hypothetical protein 0.0036 0.0522 0.0957
Echinococcus granulosus solute carrier family 22 0.0015 0.0035 0.0068
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0585 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0065 0.119 0.1159
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0236 0.0375
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0543 0.051
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0138 0.0207
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Echinococcus multilocularis solute carrier family 22 0.0015 0.0035 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0236 0.0424
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0437 0.0751
Onchocerca volvulus 0.0036 0.0522 0.1864
Loa Loa (eye worm) hypothetical protein 0.0043 0.0695 0.1278
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0522 0.0726
Schistosoma mansoni glucose transport protein 0.0105 0.2122 0.3295
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0082 0.0185
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0872 0.1563
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0522 0.0726
Echinococcus multilocularis cysteine protease 0.0065 0.119 0.2946
Echinococcus multilocularis General substrate transporter 0.009 0.1781 0.4418
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.0695 0.0844
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0236 0.0201
Onchocerca volvulus Cathepsin L homolog 0.0065 0.119 0.4417
Leishmania major cathepsin L-like protease 0.0065 0.119 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1257 0.193
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0792 0.1954
Schistosoma mansoni Smad4 0.0017 0.0082 0.0074
Echinococcus multilocularis cysteine protease 0.0065 0.119 0.2946
Loa Loa (eye worm) hypothetical protein 0.0047 0.0792 0.1457
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.0188 0.1327
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0522 0.1235
Echinococcus granulosus lamin 0.0028 0.0344 0.0839
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Leishmania major protein kinase, putative 0.0032 0.0437 0.3483
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0021 0.0188 0.0336
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0062
Mycobacterium ulcerans beta-lactamase 0.0036 0.0522 0.157
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0586 0.0821
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0522 0.0489
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0522 0.0769
Loa Loa (eye worm) sugar transporter 0.0015 0.0035 0.0051
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0438 0.0404
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0138 0.0162
Echinococcus granulosus solute carrier family 22 0.0015 0.0035 0.0068
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0021 0.0188 0.0286
Entamoeba histolytica protein kinase, putative 0.0032 0.0437 0.0453
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0437 0.1071
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0138 0.089
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0422 0.0611
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0447 0.0614
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2122 0.5269
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0586 0.1441
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0138 0.1159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Brugia malayi MH2 domain containing protein 0.0017 0.0082 0.0087
Brugia malayi MH1 domain containing protein 0.0017 0.0082 0.0087
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0082 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.119 0.1721
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0522 0.1283
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0872 0.1606
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0422 0.0577
Brugia malayi intermediate filament protein 0.0028 0.0344 0.0577
Leishmania major cathepsin L-like protease 0.0065 0.119 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0585 0.0819
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Brugia malayi Papain family cysteine protease containing protein 0.0065 0.119 0.2157
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0422 0.0723
Leishmania major glucose transporter, lmgt1 0.0033 0.0447 0.3565
Brugia malayi hypothetical protein 0.0016 0.0062 0.005
Onchocerca volvulus 0.0065 0.119 0.4417
Onchocerca volvulus 0.0065 0.119 0.4417
Schistosoma mansoni DNA polymerase eta 0.0019 0.0138 0.0162
Onchocerca volvulus 0.0065 0.119 0.4417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0422 0.1033
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0062
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0437 0.1071
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Onchocerca volvulus 0.0065 0.119 0.4417
Leishmania major cathepsin L-like protease 0.0065 0.119 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0438 0.0404
Onchocerca volvulus 0.0028 0.0344 0.1183
Echinococcus multilocularis Smad4 0.0017 0.0082 0.0185
Schistosoma mansoni hypothetical protein 0.0105 0.2122 0.3295
Leishmania major DNA polymerase eta, putative 0.0019 0.0138 0.089
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0586 0.4769
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0391 0.0956
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0872 0.1321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.6745 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0491 0.0921
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0138 0.089
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0138 0.0331
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0447 0.3755
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0944 0.2332
Trichomonas vaginalis esterase, putative 0.0036 0.0522 0.0726
Brugia malayi MH1 domain containing protein 0.0017 0.0082 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.0188 0.0336
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0264 0.023
Loa Loa (eye worm) hypothetical protein 0.0065 0.119 0.2197
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0074 0.0124
Leishmania major cathepsin L-like protease 0.0065 0.119 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0438 0.0617
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.119 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.4988 1
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0464 0.0494
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0585 0.1438
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.119 0.1721
Loa Loa (eye worm) hypothetical protein 0.0128 0.2649 0.4909
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0522 0.091
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0464 0.0494
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0138 0.0207
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0065 0.119 0.2197
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0074 0.0073
Plasmodium falciparum mitogen-activated protein kinase 2 0.017 0.3618 0.3595
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0872 0.2154
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0082 0.0138
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0447 0.3565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.119 1
Echinococcus granulosus cathepsin L 0.0033 0.0464 0.1138
Loa Loa (eye worm) hypothetical protein 0.0021 0.0188 0.0336
Loa Loa (eye worm) sugar transporter 0.0105 0.2122 0.3929
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0138 0.1159
Schistosoma mansoni hypothetical protein 0.0036 0.0516 0.0759
Onchocerca volvulus Cathepsin F homolog 0.0065 0.119 0.4417
Brugia malayi Cathepsin L-like precursor 0.0043 0.0695 0.1233
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0138 0.1159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0438 0.0404
Leishmania major DNA polymerase kappa, putative 0.0019 0.0138 0.089
Brugia malayi beta-lactamase 0.0036 0.0522 0.091
Echinococcus multilocularis solute carrier family 22 0.0015 0.0035 0.0068
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0074 0.0166
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0464 0.3718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2122 0.5269
Loa Loa (eye worm) hypothetical protein 0.0036 0.0522 0.0957
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.5389 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0065 0.119 0.2197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0464 0.3903
Schistosoma mansoni inositol monophosphatase 0.0039 0.0585 0.0868
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0236 0.1737
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0236 0.1737
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0042 0.0064
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.119 1
Brugia malayi mbt repeat family protein 0.0047 0.0792 0.1413
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0438 0.0404
Trypanosoma cruzi cysteine protease, putative 0.0033 0.0464 0.3718
Trypanosoma brucei glucose transporter, putative 0.0033 0.0447 0.3755
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0264 0.1982
Trypanosoma brucei glucose transporter, putative 0.0033 0.0447 0.3755
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0138 0.1159
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0585 0.0819
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.6745 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0065 0.119 0.2946
Schistosoma mansoni cathepsin F (C01 family) 0.0065 0.119 0.1823
Echinococcus multilocularis solute carrier family 22 0.0015 0.0035 0.0068
Brugia malayi TAR-binding protein 0.0068 0.1257 0.2283
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Schistosoma mansoni protein kinase 0.0032 0.0437 0.0635
Echinococcus granulosus GPCR family 2 0.0016 0.0074 0.0166
Brugia malayi Inositol-1 0.0039 0.0585 0.1027
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1158 0.1774
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0522 0.0984
Mycobacterium tuberculosis Conserved protein 0.0036 0.0522 0.0984
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0138 0.0153
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0447 0.3565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0695 0.0984
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.3138 0.6264
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0586 0.1441
Trypanosoma cruzi cruzipain precursor, putative 0.0021 0.0188 0.1327
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0586 0.1441
Loa Loa (eye worm) hypothetical protein 0.0032 0.0422 0.077
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1257 0.193
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0236 0.0299
Brugia malayi Cathepsin L-like precursor 0.0043 0.0695 0.1233
Mycobacterium ulcerans hypothetical protein 0.0036 0.0522 0.157
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0447 0.3565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.6745 1
Brugia malayi Cathepsin L-like precursor 0.0065 0.119 0.2157
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0236 0.0274
Schistosoma mansoni smad1 5 8 and 0.0017 0.0082 0.0074
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0062
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0236 0.0201
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0438 0.0404
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.1257 0.2283
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0522 0.0984
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0138 0.0153
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0522 0.0984
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2122 0.5269
Loa Loa (eye worm) hypothetical protein 0.0026 0.0286 0.0516
Trypanosoma brucei glucose transporter, putative 0.0033 0.0447 0.3755
Echinococcus granulosus cathepsin L cysteine protease 0.0033 0.0464 0.1138
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0792 0.1954
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.119 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0033 0.0464 0.0431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.119 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0437 0.1071
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0516 0.0898
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0422 0.0899
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0138 0.0192
Onchocerca volvulus 0.0047 0.0792 0.2894
Loa Loa (eye worm) ctsf protein 0.0065 0.119 0.2197
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0422 0.0577
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0391 0.0956
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0138 0.1159
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0035 0.0068
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0154 0.024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0074 0.0166
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0422 0.1033
Toxoplasma gondii cathepsin CPL 0.0065 0.119 0.1771
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.119 0.1721
Echinococcus granulosus solute carrier family 22 0.0015 0.0035 0.0068
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.3138 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0522 0.0957
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0792 0.1195
Brugia malayi Cathepsin L-like precursor 0.0065 0.119 0.2157
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.119 0.1721
Schistosoma mansoni lamin 0.0028 0.0344 0.0488
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0585 0.4914
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.3138 1
Onchocerca volvulus Cathepsin L homolog 0.0065 0.119 0.4417
Schistosoma mansoni cathepsin F (C01 family) 0.0065 0.119 0.1823
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0138 0.1159
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0043 0.0695 0.5717
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0138 0.1159
Loa Loa (eye worm) cysteine protease 0.0065 0.119 0.2197
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0586 0.0678
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0065 0.119 0.1721
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0344 0.0626
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0082 0.0185
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0422 0.0723
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0438 0.0404
Leishmania major cathepsin L-like protease 0.0065 0.119 1
Schistosoma mansoni smad 0.0017 0.0082 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0138 0.1159
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0438 0.0404
Entamoeba histolytica hypothetical protein 0.0023 0.0236 0.0148
Schistosoma mansoni cathepsin s 0.0021 0.0188 0.0242
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0065 0.119 0.1159
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0792 0.1954
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0585 0.0819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Brugia malayi Smad1 0.0017 0.0082 0.0087
Brugia malayi cathepsin F-like cysteine proteinase 0.0021 0.0188 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0447 0.0614
Onchocerca volvulus 0.0065 0.119 0.4417
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Loa Loa (eye worm) RNA binding protein 0.0068 0.1257 0.2323
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0236 0.0568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0464 0.3903
Onchocerca volvulus 0.0043 0.0695 0.2525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.6745 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.6745 1
Plasmodium vivax hexose transporter 0.0105 0.2122 0.2094
Loa Loa (eye worm) TAR-binding protein 0.0068 0.1257 0.2323
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.2122 0.5269
Leishmania major hypothetical protein, conserved 0.0025 0.0264 0.1982
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0543 0.051
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0464 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.2122 0.311
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0543 0.4563
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0792 0.1195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.119 1
Schistosoma mansoni lamin 0.0028 0.0344 0.0488
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0035 0.0051
Echinococcus multilocularis tar DNA binding protein 0.0068 0.1257 0.3115
Onchocerca volvulus Huntingtin homolog 0.0128 0.2649 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0344 0.0488
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0522 0.1283
Brugia malayi Cathepsin L-like precursor 0.0065 0.119 0.2157
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Echinococcus granulosus cathepsin l1 0.0065 0.119 0.2946
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0074 0.0166
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.119 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.402 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0074 0.0166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.119 0.1721
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0447 0.0614
Onchocerca volvulus Huntingtin homolog 0.0128 0.2649 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0344 0.0626
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.119 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0464 0.0678
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0586 0.0821
Leishmania major hypothetical protein, conserved 0.0036 0.0522 0.422
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0896 0.1609
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0586 0.4923
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0437 0.1071
Entamoeba histolytica cysteine proteinase 1, putative 0.0033 0.0464 0.0494
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0522 0.0984
Mycobacterium tuberculosis Conserved protein 0.0036 0.0522 0.0984
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0124
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Entamoeba histolytica cysteine protease, putative 0.0033 0.0464 0.0494
Leishmania major cysteine peptidase A (CPA) 0.0065 0.119 1
Schistosoma mansoni glucose transport protein 0.0105 0.2122 0.3295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.119 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.6745 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2122 0.5269
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0447 0.3755
Brugia malayi Cathepsin L-like precursor 0.0021 0.0188 0.0286
Trypanosoma brucei glucose transporter 2A 0.0033 0.0447 0.3755
Echinococcus granulosus dna polymerase kappa 0.0019 0.0138 0.0325
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0585 0.476
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0082 0.0074
Echinococcus multilocularis dna polymerase eta 0.0019 0.0138 0.0325
Loa Loa (eye worm) hypothetical protein 0.0036 0.0522 0.0957
Loa Loa (eye worm) hypothetical protein 0.0054 0.0944 0.1739
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0236 0.1981
Echinococcus granulosus General substrate transporter 0.009 0.1781 0.4418
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0543 0.4398
Onchocerca volvulus 0.0028 0.0344 0.1183
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0944 0.1697
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0585 0.0676
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1257 0.193
Toxoplasma gondii ABC1 family protein 0.0036 0.0522 0.0747
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0138 0.1159
Trypanosoma brucei glucose transporter, putative 0.0033 0.0447 0.3755
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.017 0.3618 0.5495
Plasmodium falciparum hexose transporter 0.0105 0.2122 0.2094
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.0476
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1158 0.362
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1158 0.2268
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0447 0.0614
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0543 0.0779
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.119 0.1721
Loa Loa (eye worm) hypothetical protein 0.0039 0.0586 0.1074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.119 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0464 0.0494
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0586 0.4769
Schistosoma mansoni glucose transport protein 0.0105 0.2122 0.3295
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0872 0.2154
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0586 0.1441
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Brugia malayi Sugar transporter family protein 0.0105 0.2122 0.3898
Onchocerca volvulus 0.0036 0.0522 0.1864
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0264 0.2218
Loa Loa (eye worm) fibroinase 0.0065 0.119 0.2197
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0138 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.119 1
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0464 0.0802
Echinococcus granulosus dna polymerase eta 0.0019 0.0138 0.0325
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0035 0.0295
Trypanosoma brucei unspecified product 0.0019 0.0138 0.1159
Echinococcus granulosus cathepsin l1 0.0043 0.0695 0.1713
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0792 0.1195
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.119 0.1592
Brugia malayi beta-lactamase family protein 0.0036 0.0522 0.091
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0543 0.4398
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1257 0.193
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0447 0.0614
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.119 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0585 0.476
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1158 0.362
Trypanosoma brucei sugar transporter, putative 0.0015 0.0035 0.0295
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1158 0.2868
Brugia malayi Cathepsin L-like precursor 0.0065 0.119 0.2157
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0236 0.0646
Brugia malayi MH2 domain containing protein 0.0246 0.5389 1
Brugia malayi beta-lactamase family protein 0.0036 0.0522 0.091
Loa Loa (eye worm) hypothetical protein 0.0032 0.0422 0.077
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0138 0.0331
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0236 0.0317
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0792 0.1457
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0896 0.1651
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0138 0.0325
Mycobacterium tuberculosis Conserved protein 0.0036 0.0522 0.0984
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.119 0.1721
Loa Loa (eye worm) hypothetical protein 0.0028 0.0332 0.0603
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0438 0.0617
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0154 0.024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Onchocerca volvulus 0.0036 0.0522 0.1864
Brugia malayi Cam kinase protein 1 0.0032 0.0437 0.0751
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0522 0.422
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0586 0.1029
Loa Loa (eye worm) inositol-1 0.0039 0.0585 0.1072
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0051
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0138 0.0325
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0033 0.0464 0.3718

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) 69.497 uM PubChem BioAssay. Counterscreen for exosite inhibitors of ADAM10: QFRET-based biochemical high throughput dose response assay to identify inhibitors of ADAM17. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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