Detailed information for compound 1300231

Basic information

Technical information
  • TDR Targets ID: 1300231
  • Name: 5,8-dimethyl-1-(2-oxo-2-pyrrolidin-1-ylethyl) -3-phenylpyrimido[5,6-b]indole-2,4-dione
  • MW: 416.472 | Formula: C24H24N4O3
  • H donors: 0 H acceptors: 3 LogP: 3.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c1c(n2C)c(=O)n(c(=O)n1CC(=O)N1CCCC1)c1ccccc1
  • InChi: 1S/C24H24N4O3/c1-16-10-11-19-18(14-16)21-22(25(19)2)23(30)28(17-8-4-3-5-9-17)24(31)27(21)15-20(29)26-12-6-7-13-26/h3-5,8-11,14H,6-7,12-13,15H2,1-2H3
  • InChiKey: QGSOSKBNRFXANO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5,8-dimethyl-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-3-phenyl-pyrimido[5,6-b]indole-2,4-dione
  • 5,8-dimethyl-1-(2-oxo-2-1-pyrrolidinylethyl)-3-phenylpyrimido[5,6-b]indole-2,4-dione
  • 1-(2-keto-2-pyrrolidin-1-yl-ethyl)-5,8-dimethyl-3-phenyl-pyrimido[5,6-b]indole-2,4-quinone
  • E737-0477
  • NCGC00141553-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus axis inhibition protein axin 0.004 0.0311 0.0316
Mycobacterium tuberculosis Probable oxidoreductase 0.0734 0.792 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.006 0.0522 0.0522
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0122 0.0353
Echinococcus multilocularis dna polymerase eta 0.0085 0.0797 0.0812
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0129 0.0129
Brugia malayi PHD-finger family protein 0.0091 0.0867 0.0884
Loa Loa (eye worm) hypothetical protein 0.0018 0.0071 0.0072
Toxoplasma gondii thioredoxin reductase 0.029 0.3043 0.8893
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0311 0.0316
Loa Loa (eye worm) hypothetical protein 0.004 0.0311 0.0318
Echinococcus multilocularis jumonji domain containing protein 0.0127 0.1259 0.1284
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.019 0.0194
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.058 0.0591
Entamoeba histolytica hypothetical protein 0.0035 0.0256 0.026
Schistosoma mansoni disulfide oxidoreductase 0.0027 0.016 0.016
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0071 0.0071
Leishmania major sir2-family protein-like protein 0.0218 0.2262 0.2308
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.01 0.0968 0.0987
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0194 0.0564
Brugia malayi serine/threonine-protein kinase plk-2 0.0399 0.4245 0.4333
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0522 0.0532
Leishmania major hypothetical protein, conserved 0.0466 0.4976 0.5079
Trichomonas vaginalis CAMK family protein kinase 0.0399 0.4245 0.4333
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0549 0.5883 0.6006
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0522 0.0532
Schistosoma mansoni chromobox protein 0.0023 0.0122 0.0122
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0071 0.0202
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0106 0.1027 0.1163
Loa Loa (eye worm) hypothetical protein 0.004 0.0311 0.0318
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0311 0.0316
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0734 0.792 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.01 0.0968 0.5354
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0575 0.0587
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0071 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0122 0.0123
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1449 0.1479
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.01 0.0968 0.0987
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.058 0.058
Schistosoma mansoni glutamate synthase 0.0027 0.016 0.016
Schistosoma mansoni chromobox protein 0.0023 0.0122 0.0122
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0324 0.3422 0.4233
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.019 0.0193
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.019 0.0193
Plasmodium falciparum ferrodoxin reductase-like protein 0.0027 0.016 0.0463
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.016 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0325 0.0325
Echinococcus granulosus phosphoglycerate kinase 1 0.0167 0.1704 0.1738
Entamoeba histolytica hypothetical protein 0.004 0.0311 0.0316
Schistosoma mansoni hypothetical protein 0.0035 0.0256 0.0256
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.0542 0.0552
Echinococcus granulosus tumor protein p63 0.0408 0.4342 0.4432
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.7313 0.7466
Onchocerca volvulus 0.0389 0.4135 0.9735
Plasmodium falciparum glutathione reductase 0.01 0.0968 0.2826
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0968 0.0987
Loa Loa (eye worm) hypothetical protein 0.0091 0.0867 0.0886
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0523 0.0469
Loa Loa (eye worm) hypothetical protein 0.0029 0.019 0.0194
Toxoplasma gondii NADPH-glutathione reductase 0.01 0.0968 0.2826
Echinococcus granulosus glutamate synthase 0.0027 0.016 0.0162
Echinococcus granulosus axis inhibition protein axin 0.004 0.0311 0.0316
Brugia malayi RNA binding protein 0.0064 0.0575 0.0585
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.016 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0522 0.0532
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0575 0.0585
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0213 0.0619
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0968 0.0987
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.004 0.0311 0.0318
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0523 0.0523
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0399 0.4245 0.4334
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0311 0.0318
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.016 0.0162
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0127 0.0128
Plasmodium falciparum thioredoxin reductase 0.029 0.3043 0.8893
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0522 0.0532
Brugia malayi ShTK domain containing protein 0.0389 0.4135 0.4221
Toxoplasma gondii PHD-finger domain-containing protein 0.0091 0.0867 0.2531
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.016 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0122 0.0123
Loa Loa (eye worm) hypothetical protein 0.0085 0.0797 0.0814
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0122 0.0123
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0523 0.0469
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0218 0.2262 0.2308
Brugia malayi jmjC domain containing protein 0.0299 0.3142 0.3206
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0027 0.016 0.0162
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0389 0.4135 0.4221
Loa Loa (eye worm) hypothetical protein 0.0389 0.4135 0.4222
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0006 0.0005
Leishmania major silent information regulator 2, putative 0.0905 0.9795 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0311 0.0316
Trichomonas vaginalis CAMK family protein kinase 0.0399 0.4245 0.4333
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0575 0.0575
Echinococcus granulosus beta-adrenergic receptor kinase 0.0042 0.0325 0.033
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0324 0.3422 0.3492
Trypanosoma brucei unspecified product 0.0041 0.0319 0.0324
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0324 0.3422 0.3492
Schistosoma mansoni hypothetical protein 0.0018 0.0071 0.0071
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0575 0.0575
Onchocerca volvulus 0.0024 0.0129 0.0016
Trichomonas vaginalis apoptosis inducing factor, putative 0.0027 0.016 0.0162
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0523 0.0516
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0455 0.1325
Schistosoma mansoni hypothetical protein 0.0018 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0311 0.0316
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.006 0.0522 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0311 0.0316
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0027 0.016 0.0463
Leishmania major acetoin dehydrogenase e3 component-like protein 0.01 0.0968 0.0987
Plasmodium vivax JmjC domain containing protein 0.0029 0.019 0.0552
Giardia lamblia Sirtuin type 2 0.0218 0.2262 0.2308
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.016 0.0162
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0542 0.0552
Loa Loa (eye worm) glutaminase 0.0897 0.9703 0.9906
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0122 0.0122
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0071 0.0071
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0456 0.0464
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.01 0.0968 0.2826
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.058 0.0591
Echinococcus granulosus chromobox protein 1 0.0142 0.1423 0.1452
Treponema pallidum thioredoxin reductase (trxB) 0.0027 0.016 0.0251
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.016 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0125
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.01 0.0968 0.0987
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0324 0.3422 0.3492
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0311 0.0316
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0299 0.3142 0.3206
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0319 0.0324
Entamoeba histolytica hypothetical protein, conserved 0.0218 0.2262 0.2308
Leishmania major trypanothione reductase 0.029 0.3043 0.3106
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0006 0.0005
Plasmodium vivax glutathione reductase, putative 0.029 0.3043 0.8893
Schistosoma mansoni hypothetical protein 0.0027 0.016 0.016
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0346 0.0351
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.019 0.0193
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.1704 0.1738
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.016 0.0162
Echinococcus multilocularis chromobox protein 1 0.0142 0.1423 0.1452
Onchocerca volvulus Heterochromatin protein 1 homolog 0.008 0.074 0.1497
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0218 0.2262 0.2308
Onchocerca volvulus 0.0389 0.4135 0.9735
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0178 0.0181
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0027 0.016 0.0162
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.016 0.0162
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0968 0.0987
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0485 0.0494
Loa Loa (eye worm) hypothetical protein 0.008 0.074 0.0755
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0905 0.9795 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.01 0.0968 0.0932
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0193 0.0195
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0905 0.9795 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0031 0.0208 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0071 0.0071
Brugia malayi glutathione reductase 0.029 0.3043 0.3106
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0522 0.0532
Trypanosoma cruzi trypanothione reductase, putative 0.029 0.3043 0.3106
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0325 0.0325
Schistosoma mansoni cpg binding protein 0.0028 0.0178 0.0178
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0122 0.0353
Trypanosoma brucei unspecified product 0.006 0.0522 0.0532
Chlamydia trachomatis thioredoxin reductase 0.0027 0.016 0.0251
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0122 0.0123
Brugia malayi glutaminase DH11.1 0.0897 0.9703 0.9906
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0523 0.0523
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.01 0.0968 0.0987
Loa Loa (eye worm) hypothetical protein 0.004 0.0311 0.0318
Leishmania major hypothetical protein, conserved 0.0027 0.016 0.0162
Trichomonas vaginalis chromobox protein, putative 0.0142 0.1423 0.1452
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0167 0.1704 0.4977
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.016 0.0162
Mycobacterium tuberculosis Probable dehydrogenase 0.0661 0.7111 0.8964
Trichomonas vaginalis glutathione reductase, putative 0.01 0.0968 0.0987
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.006 0.0522 0.0533
Mycobacterium ulcerans phosphoglycerate kinase 0.0167 0.1704 0.1696
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.01 0.0968 0.0987
Entamoeba histolytica serine/threonine protein kinase, putative 0.0399 0.4245 0.4333
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0522 0.0532
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0167 0.1704 0.2031
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0029 0.019 0.0194
Echinococcus granulosus tar DNA binding protein 0.0064 0.0575 0.0585
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0311 0.0316
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0054 0.0456 0.04
Echinococcus multilocularis chromobox protein 2 0.0023 0.0122 0.0123
Loa Loa (eye worm) hypothetical protein 0.0389 0.4135 0.4222
Schistosoma mansoni phd/f-box containing protein 0.0029 0.019 0.019
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0311 0.0316
Mycobacterium ulcerans hypothetical protein 0.0054 0.0456 0.04
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0122 0.0353
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0324 0.3422 0.3492
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0072 0.0072
Onchocerca volvulus 0.0062 0.0551 0.1041
Trichomonas vaginalis CAMK family protein kinase 0.0399 0.4245 0.4333
Onchocerca volvulus 0.0389 0.4135 0.9735
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.058 0.0591
Brugia malayi PXA domain containing protein 0.004 0.0311 0.0316
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.014 0.014
Echinococcus multilocularis PHD finger protein rhinoceros 0.0091 0.0867 0.0884
Mycobacterium ulcerans hypothetical protein 0.0027 0.016 0.0092
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0661 0.7111 0.8964
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0968 0.0987
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0575 0.0575
Schistosoma mansoni regulator of G protein signaling 0.004 0.0311 0.0311
Echinococcus multilocularis beta adrenergic receptor kinase 0.0042 0.0325 0.033
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.1704 0.1738
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0167 0.1704 0.4977
Loa Loa (eye worm) thioredoxin reductase 0.029 0.3043 0.3107
Schistosoma mansoni hypothetical protein 0.0018 0.0071 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2035 0.2076
Plasmodium falciparum glutathione reductase 0.029 0.3043 0.8893
Echinococcus multilocularis phd:f box containing protein 0.0029 0.019 0.0193
Schistosoma mansoni chromobox protein 0.0142 0.1423 0.1423
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0071 0.0071
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0905 0.9795 1
Leishmania major DNA damage repair protein, putative 0.0019 0.0071 0.0071
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0765 0.0779
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0027 0.016 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0071 0.0071
Schistosoma mansoni jumonji/arid domain-containing protein 0.0112 0.1095 0.1095
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0071 0.0202
Brugia malayi TAR-binding protein 0.0064 0.0575 0.0585
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.016 0.0162
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0071 0.007
Trypanosoma brucei SIR2-like protein 4, putative 0.0218 0.2262 0.2308
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.1704 0.1738
Plasmodium vivax NAD-dependent deacetylase, putative 0.0324 0.3422 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0125
Echinococcus granulosus PHD finger protein rhinoceros 0.0091 0.0867 0.0884
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0549 0.5883 0.6006
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.028 0.0284
Plasmodium falciparum phd finger protein, putative 0.0091 0.0867 0.2531
Trichomonas vaginalis chromobox protein, putative 0.0086 0.0806 0.0821
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.1704 0.1738
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.0194 0.0197
Brugia malayi hypothetical protein 0.0023 0.0122 0.0123
Mycobacterium ulcerans ferredoxin reductase 0.0027 0.016 0.0092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0122 0.0123
Schistosoma mansoni hypothetical protein 0.004 0.0306 0.0306
Giardia lamblia Hypothetical protein 0.0905 0.9795 1
Entamoeba histolytica hypothetical protein 0.0023 0.0122 0.0123
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0122 0.0123
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0509 0.0518
Trypanosoma cruzi hypothetical protein, conserved 0.0466 0.4976 0.5079
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.01 0.0968 0.0987
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0324 0.3422 0.3492
Schistosoma mansoni chromatin regulatory protein sir2 0.0905 0.9795 0.9795
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.1704 0.1738
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0218 0.2262 0.661
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.01 0.0968 0.1087
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0311 0.0316
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0325 0.0325
Schistosoma mansoni kinase 0.0203 0.2092 0.2092
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0509 0.0519
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0522 0.0532
Mycobacterium ulcerans NADH dehydrogenase 0.0027 0.016 0.0092
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0027 0.016 0.0162
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0027 0.016 0.0051
Leishmania major hypothetical protein, conserved 0.0027 0.016 0.0162
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0071 0.007
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0054 0.0456 0.0431
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0027 0.016 0.0051
Trypanosoma cruzi polo-like protein kinase, putative 0.0399 0.4245 0.4333
Brugia malayi transcriptional regulator, Sir2 family protein 0.0218 0.2262 0.2308
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.003 0.0194 0.0564
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0027 0.016 0.0092
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0549 0.5883 0.6006
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0042 0.0325 0.0332
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0389 0.4135 0.4221
Plasmodium vivax thioredoxin reductase, putative 0.029 0.3043 0.8893
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0071 0.0071
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0324 0.3422 1
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0389 0.4135 0.4221
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0389 0.4135 0.4221
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.016 0.0162
Echinococcus granulosus lysine specific demethylase 5A 0.0112 0.1095 0.1117
Echinococcus multilocularis phosphoglycerate kinase 1 0.0167 0.1704 0.1738
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.012 0.0346
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0311 0.0316
Echinococcus multilocularis Chromo domain 0.0023 0.0122 0.0123
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.019 0.0193
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.01 0.0968 0.0987
Trichomonas vaginalis chromobox protein, putative 0.0086 0.0806 0.0821
Trichomonas vaginalis conserved hypothetical protein 0.008 0.074 0.0754
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0031 0.0208 0.0211
Echinococcus granulosus cpg binding protein 0.003 0.0195 0.0198
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0523 0.0532
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0027 0.016 0.0162
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0122 0.0353
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.006 0.0522 0.0532
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0027 0.016 0.0463
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0122 0.0353
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.058 0.0591
Toxoplasma gondii histone deacetylase SIR2-like 0.0218 0.2262 0.661
Loa Loa (eye worm) glutathione reductase 0.029 0.3043 0.3107
Schistosoma mansoni axis inhibition protein axin 0.004 0.0311 0.0311
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0122 0.0123
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.019 0.0193
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0027 0.016 0.0162
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0765 0.0765
Loa Loa (eye worm) RNA binding protein 0.0064 0.0575 0.0587
Toxoplasma gondii selenide, water dikinase 0.0027 0.016 0.0463
Brugia malayi polk-prov protein 0.0019 0.0071 0.0071
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0324 0.3422 0.3492
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0027 0.016 0.0051
Brugia malayi Bromodomain containing protein 0.0091 0.0867 0.0884
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0575 0.0587
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.01 0.0968 0.0932
Schistosoma mansoni axis inhibition protein axin 0.004 0.0311 0.0311
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0218 0.2262 0.2308
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0311 0.0316
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0218 0.2262 0.2308
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0346 0.1006
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0071 0.0071
Schistosoma mansoni regulator of G protein signaling 0.004 0.0311 0.0311
Brugia malayi CHD4 protein 0.0025 0.014 0.0141
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0127 0.0128
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0071 0.0071
Mycobacterium ulcerans NAD-dependent deacetylase 0.0324 0.3422 0.3479
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.016 0.0162
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.016 0.0162
Loa Loa (eye worm) sirtuin 4 0.0218 0.2262 0.231
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0765 0.0779
Echinococcus multilocularis peregrin 0.0091 0.0867 0.0884
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0071 0.0071
Loa Loa (eye worm) jmjC domain-containing protein 0.0188 0.1932 0.1972
Entamoeba histolytica hypothetical protein 0.0035 0.0256 0.026
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0765 0.0779
Brugia malayi jmjC domain containing protein 0.0029 0.019 0.0193
Trypanosoma brucei DNA polymerase eta, putative 0.0085 0.0797 0.0812
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0549 0.5883 0.6006
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0311 0.0311
Echinococcus granulosus phd:f box containing protein 0.0029 0.019 0.0193
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0311 0.0316
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0522 0.0532
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.019 0.0193
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.019 0.0552
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0027 0.016 0.0051
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0027 0.016 0.0092
Brugia malayi PXA domain containing protein 0.004 0.0311 0.0316
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0549 0.5883 0.6006
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.016 0.0162
Mycobacterium ulcerans Sir2-like regulatory protein 0.0218 0.2262 0.2275
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.058 0.0591
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0122 0.0353
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0027 0.016 0.0162
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0122 0.0122
Giardia lamblia Kinase, PLK 0.0399 0.4245 0.4333
Brugia malayi transcriptional regulator, Sir2 family protein 0.0905 0.9795 1
Trichomonas vaginalis chromobox protein, putative 0.0142 0.1423 0.1452
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0311 0.0316
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.016 0.0162
Schistosoma mansoni cpg binding protein 0.003 0.0195 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.0399 0.4245 0.4333
Leishmania major dihydrolipoamide dehydrogenase, putative 0.01 0.0968 0.0987
Loa Loa (eye worm) RGS-3 protein 0.004 0.0311 0.0318
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0122 0.0123
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.019 0.0552
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0271 0.0271
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0027 0.016 0.0051
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0071 0.0072
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0522 0.0516
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0122 0.0123
Brugia malayi glutamate synthase 0.0027 0.016 0.0162
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0734 0.792 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0549 0.5883 0.6006
Toxoplasma gondii PHD-finger domain-containing protein 0.0091 0.0867 0.2531
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0054 0.0456 0.0464
Schistosoma mansoni tyrosinase precursor 0.0389 0.4135 0.4135
Echinococcus granulosus citrate lyase subunit beta protein 0.0054 0.0456 0.0464
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0193 0.0195
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0905 0.9795 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0027 0.016 0.0162
Schistosoma mansoni glutamate synthase 0.0027 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.004 0.0306 0.0312
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.012 0.0346
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.016 0.0162
Echinococcus granulosus jumonji domain containing protein 0.0127 0.1259 0.1284
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0086 0.0806 0.1658
Brugia malayi jmjC domain containing protein 0.0112 0.1095 0.1117
Echinococcus granulosus thioredoxin glutathione reductase 0.029 0.3049 0.3111
Onchocerca volvulus 0.0027 0.016 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0122 0.0123
Loa Loa (eye worm) hypothetical protein 0.0119 0.1171 0.1196
Brugia malayi Phosphoglycerate kinase 0.0167 0.1704 0.1738
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.01 0.0968 0.2826
Loa Loa (eye worm) glutaminase 2 0.0897 0.9703 0.9906
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0456 0.0464
Trypanosoma brucei NADH dehydrogenase 0.0027 0.016 0.0162
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.016 0.0162
Brugia malayi SET domain containing protein 0.0024 0.0129 0.013
Entamoeba histolytica hypothetical protein 0.0023 0.0122 0.0123
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0006 0.0005
Giardia lamblia Phosphoglycerate kinase 0.0167 0.1704 0.1738
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0256 0.026
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0324 0.3422 0.3492
Loa Loa (eye worm) transcriptional regulator 0.0905 0.9795 1
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0122 0.0123
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0256 0.026
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.016 0.0162
Schistosoma mansoni protein phosphatase 2C 0.0029 0.019 0.019
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.016 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0125
Onchocerca volvulus 0.0389 0.4135 0.9735
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.1704 0.1738
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0122 0.0353
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0193 0.0195
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0125
Trypanosoma cruzi DNA polymerase eta, putative 0.0085 0.0797 0.0812
Echinococcus granulosus expressed protein 0.0787 0.8498 0.8676
Loa Loa (eye worm) hypothetical protein 0.0031 0.0212 0.0217
Trypanosoma brucei hypothetical protein, conserved 0.0466 0.4976 0.5079
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0522 0.0532
Trichomonas vaginalis CAMK family protein kinase 0.0399 0.4245 0.4333
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0522 0.0469
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0027 0.016 0.0162
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0071 0.007
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.012 0.0121
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0523 0.0532
Loa Loa (eye worm) ShTK domain-containing protein 0.0389 0.4135 0.4222
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0905 0.9795 1
Mycobacterium ulcerans glutaminase 0.0897 0.9703 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0027 0.016 0.0162
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0027 0.016 0.0051
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.016 0.0162
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0122 0.0123
Brugia malayi chromobox protein homolog 3 0.008 0.074 0.0754
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0522 0.0532
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.7313 0.7313
Schistosoma mansoni chromatin regulatory protein sir2 0.0218 0.2262 0.2262
Echinococcus multilocularis chromatin regulatory protein sir2 0.0905 0.9795 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0311 0.0318
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0522 0.0532
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0122 0.0123
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.019 0.0193
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.019 0.019
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0311 0.0316
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0661 0.7111 0.8964
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0071 0.0202
Schistosoma mansoni regulator of G protein signaling 0.004 0.0311 0.0311
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0311 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0522 0.0532
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0193 0.0195
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0522 0.0532
Loa Loa (eye worm) RecQ helicase 0.0024 0.0127 0.0129
Entamoeba histolytica hypothetical protein 0.0023 0.012 0.0121
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0311 0.0311
Brugia malayi F/Y-rich N-terminus family protein 0.0038 0.0289 0.0294
Giardia lamblia PHD finger protein 15 0.0091 0.0867 0.0884
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.016 0.0162
Schistosoma mansoni chromatin regulatory protein sir2 0.0905 0.9795 0.9795
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0218 0.2262 0.2308
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0311 0.0316
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0542 0.0552
Brugia malayi jmjC domain containing protein 0.0029 0.019 0.0193
Onchocerca volvulus 0.0028 0.0178 0.0134
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0522 0.0532
Echinococcus granulosus Chromo domain 0.0023 0.0122 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0072
Echinococcus granulosus chromobox protein 1 0.0142 0.1423 0.1452
Loa Loa (eye worm) transcriptional regulator 0.0218 0.2262 0.231
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0905 0.9795 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0319 0.0324
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.016 0.0162
Echinococcus granulosus transcription factor Dp 1 0.0038 0.028 0.0284
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0324 0.3422 0.3492
Entamoeba histolytica phosphoglycerate kinase, putative 0.0167 0.1704 0.1738
Leishmania major hypothetical protein, conserved 0.0029 0.019 0.0193
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.0542 0.0552
Entamoeba histolytica hypothetical protein 0.0023 0.0122 0.0123
Echinococcus multilocularis glutamate synthase 0.0027 0.016 0.0162
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0074 0.0676 0.0689
Plasmodium vivax phosphoglycerate kinase, putative 0.0167 0.1704 0.4977
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0027 0.016 0.0162
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.016 0.0162
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0525 0.0525
Leishmania major DNA polymerase eta, putative 0.0044 0.0346 0.0351
Schistosoma mansoni hypothetical protein 0.0023 0.0122 0.0122
Schistosoma mansoni terminal deoxycytidyl transferase 0.006 0.0522 0.0522
Brugia malayi jmjC domain containing protein 0.0029 0.019 0.0193
Mycobacterium ulcerans glutamate synthase subunit beta 0.0027 0.016 0.0092
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0027 0.016 0.0162
Onchocerca volvulus Serine\/threonine kinase homolog 0.0399 0.4245 1
Schistosoma mansoni DNA polymerase eta 0.0085 0.0797 0.0797
Echinococcus multilocularis dna polymerase kappa 0.006 0.0522 0.0532
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0734 0.792 1
Giardia lamblia DNA damage repair protein 0.0019 0.0071 0.0071
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0027 0.016 0.0051
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0399 0.4245 0.4333
Trichomonas vaginalis glutaminase, putative 0.0897 0.9703 0.9906
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.004 0.0311 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0122 0.0123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0193 0.0195
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.012 0.0346
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.01 0.0968 0.5354
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0127 0.0128
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0905 0.9795 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.01 0.0968 0.2826
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0311 0.0316
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.01 0.0968 0.2826
Entamoeba histolytica hypothetical protein 0.0035 0.0256 0.026
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.016 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0399 0.4245 0.4245
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0522 0.0532
Treponema pallidum oxidoreductase 0.0027 0.016 0.0251
Schistosoma mansoni hypothetical protein 0.0018 0.0071 0.0071
Schistosoma mansoni chromatin regulatory protein sir2 0.0218 0.2262 0.2262
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0968 0.0987
Onchocerca volvulus Alhambra homolog 0.0091 0.0867 0.1807
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0027 0.016 0.0251
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0311 0.0316
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0125
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0002 0.0002
Entamoeba histolytica deoxycytidyl transferase, putative 0.006 0.0522 0.0532
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0522 0.0532
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.016 0.0092
Toxoplasma gondii histone deacetylase SIR2 0.0324 0.3422 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0193 0.0195
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0542 0.0552
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0299 0.3142 0.3206
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.019 0.0193
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0311 0.0311
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.058 0.0591
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.012 0.0051
Brugia malayi hypothetical protein 0.004 0.0311 0.0316
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0027 0.016 0.0251
Loa Loa (eye worm) hypothetical protein 0.033 0.3489 0.3562
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0122 0.0123
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0905 0.9795 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0112 0.1095 0.1118
Brugia malayi CXXC zinc finger family protein 0.0028 0.0178 0.018
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0522 0.0532
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.016 0.0162
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0043 0.0121
Treponema pallidum NADH oxidase 0.01 0.0968 0.5354
Echinococcus multilocularis citrate lyase subunit beta protein 0.0054 0.0456 0.0464
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0127 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.0399 0.4245 0.4333
Echinococcus granulosus chromatin regulatory protein sir2 0.0905 0.9795 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0002 0.0002
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.012 0.0121
Leishmania major hypothetical protein, conserved 0.0027 0.016 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0125
Echinococcus multilocularis tumor protein p63 0.0408 0.4342 0.4432
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.029 0.3043 0.3748
Echinococcus granulosus Chromobox protein 3 0.0023 0.0122 0.0123
Mycobacterium ulcerans monoxygenase 0.0027 0.016 0.0092
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0071 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.016 0.0162
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0027 0.016 0.0463
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.016 0.0463
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.016 0.0162
Schistosoma mansoni glutaminase 0.0897 0.9703 0.9703
Loa Loa (eye worm) hypothetical protein 0.0082 0.0765 0.0781
Chlamydia trachomatis phosphoglycerate kinase 0.0167 0.1704 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.016 0.0162
Mycobacterium tuberculosis Conserved protein 0.0054 0.0456 0.0431
Plasmodium vivax ferrodoxin reductase, putative 0.0027 0.016 0.0463
Loa Loa (eye worm) hypothetical protein 0.0027 0.016 0.0163
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0661 0.7111 0.8964
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0399 0.4245 0.4333
Brugia malayi hypothetical protein 0.0035 0.0256 0.026
Echinococcus multilocularis lysine specific demethylase 5A 0.011 0.1078 0.1099
Trichomonas vaginalis conserved hypothetical protein 0.008 0.074 0.0754
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0025 0.014 0.0141
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0155 0.0156
Brugia malayi Common central domain of tyrosinase family protein 0.0389 0.4135 0.4221
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0122 0.0123
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.01 0.0968 0.0968
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0027 0.016 0.0162
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0054 0.0456 0.04
Giardia lamblia NADH oxidase lateral transfer candidate 0.01 0.0968 0.0987
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0071 0.0071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0193 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0522 0.0532
Trichomonas vaginalis CAMK family protein kinase 0.0399 0.4245 0.4333
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0167 0.1704 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0523 0.0532
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0311 0.0311
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.01 0.0968 0.0987
Brugia malayi AF-10 protein 0.003 0.0194 0.0197
Brugia malayi Phosphoglycerate kinase 0.0061 0.0542 0.0552
Giardia lamblia Glutamate synthase 0.0027 0.016 0.0162
Brugia malayi ImpB/MucB/SamB family protein 0.0085 0.0797 0.0812
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0027 0.016 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0122 0.0123
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.019 0.0193
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0311 0.0316
Brugia malayi hypothetical protein 0.004 0.0311 0.0316
Brugia malayi NAD-dependent deacetylase SIRT1 0.0549 0.5883 0.6006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0968 0.0987
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0319 0.0324
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0074 0.0676 0.0689
Leishmania major phosphoglycerate kinase B, cytosolic 0.0167 0.1704 0.1738
Onchocerca volvulus 0.006 0.0523 0.0971
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0027 0.016 0.0051
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.01 0.0968 0.0987
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0027 0.016 0.0463
Schistosoma mansoni chromatin regulatory protein sir2 0.0905 0.9795 0.9795
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0027 0.016 0.0092
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0071 0.007
Leishmania major DNA polymerase eta, putative 0.0085 0.0797 0.0812
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0311 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0311 0.0316
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0311 0.0316
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1449 0.1479
Schistosoma mansoni regulator of G protein signaling 0.004 0.0311 0.0311
Leishmania major NADH dehydrogenase, putative 0.0027 0.016 0.0162
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.016 0.0162
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.016 0.0162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0122 0.0123
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.01 0.0968 0.0987
Schistosoma mansoni hypothetical protein 0.003 0.0194 0.0194
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0032 0.0213 0.0619
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.058 0.0591
Loa Loa (eye worm) PHD-finger family protein 0.0091 0.0867 0.0886
Loa Loa (eye worm) hypothetical protein 0.006 0.0523 0.0534
Loa Loa (eye worm) hypothetical protein 0.0062 0.0551 0.0563
Plasmodium vivax hypothetical protein, conserved 0.0218 0.2262 0.661
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.019 0.0194
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.016 0.0463
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0027 0.016 0.0162
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.016 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0122 0.0123
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0027 0.016 0.0251
Trypanosoma brucei trypanothione reductase 0.029 0.3043 0.3106
Onchocerca volvulus 0.0082 0.0765 0.1558
Leishmania major dihydrolipoamide dehydrogenase, putative 0.01 0.0968 0.0987
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.1704 0.1704
Schistosoma mansoni regulator of G protein signaling 0.004 0.0311 0.0311
Entamoeba histolytica hypothetical protein 0.0035 0.0256 0.026
Loa Loa (eye worm) CHromoDomain protein family member 0.0025 0.014 0.0143
Trichomonas vaginalis hypothetical protein 0.0023 0.0122 0.0123
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0523 0.1524
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0311 0.0316
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.058 0.0591
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0027 0.016 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0071 0.0071
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0122 0.0123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0193 0.0195
Mycobacterium tuberculosis Probable reductase 0.0661 0.7111 0.8964
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0122 0.0353
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.0194 0.0197
Echinococcus granulosus GPCR family 2 0.0018 0.0071 0.007
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0523 0.0523
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0025 0.014 0.0141
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0522 0.0532
Leishmania major DNA polymerase kappa, putative 0.006 0.0522 0.0532
Schistosoma mansoni hypothetical protein 0.0091 0.0867 0.0867
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0311 0.0316
Schistosoma mansoni jumonji domain containing protein 0.0029 0.019 0.019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.016 0.0162
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0509 0.0518
Trypanosoma cruzi polo-like protein kinase, putative 0.0399 0.4245 0.4333
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0311 0.0316
Entamoeba histolytica hypothetical protein 0.004 0.0311 0.0316
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0027 0.016 0.0092
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0027 0.016 0.0092
Giardia lamblia Thioredoxin reductase 0.0027 0.016 0.0162
Brugia malayi Heterochromatin protein 1 0.0142 0.1423 0.1452
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0575 0.0585
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0167 0.1704 0.2031
Giardia lamblia Transcriptional regulator, Sir2 family 0.0324 0.3422 0.3492
Brugia malayi PHD-finger family protein 0.0031 0.0212 0.0215
Treponema pallidum phosphoglycerate kinase 0.0167 0.1704 1
Schistosoma mansoni sulfide quinone reductase 0.0027 0.016 0.016
Entamoeba histolytica disulphide oxidoreductase, putative 0.0027 0.016 0.0162
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0006 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.01 0.0968 0.2826
Loa Loa (eye worm) hypothetical protein 0.0156 0.1582 0.1615
Leishmania major DNA polymerase kappa, putative 0.0019 0.0071 0.0071
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0661 0.7111 0.8964
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0311 0.0316
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.012 0.0346
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0006 0.0005
Schistosoma mansoni glutamate synthase 0.0027 0.016 0.016
Loa Loa (eye worm) helicase 0.0023 0.0122 0.0125
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0218 0.2262 0.2308
Entamoeba histolytica hypothetical protein 0.004 0.0311 0.0316
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0522 0.0532
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0575 0.0575
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.016 0.0162
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0027 0.016 0.0463
Schistosoma mansoni tyrosinase precursor 0.0389 0.4135 0.4135
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0549 0.5883 0.6006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.01 0.0968 0.5354
Echinococcus granulosus dna polymerase kappa 0.006 0.0522 0.0532
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0122 0.0123
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0905 0.9795 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0542 0.0552
Echinococcus multilocularis GPCR, family 2 0.0018 0.0071 0.007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0661 0.7111 0.8964
Echinococcus granulosus peregrin 0.0091 0.0867 0.0884
Echinococcus granulosus dna polymerase eta 0.0085 0.0797 0.0812
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0095 0.0274
Brugia malayi jmjC domain containing protein 0.0029 0.019 0.0193
Brugia malayi transcriptional regulator, Sir2 family protein 0.0218 0.2262 0.2308
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0122 0.0123
Schistosoma mansoni cpg binding protein 0.003 0.0195 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0466 0.4976 0.5079
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0575 0.0575
Schistosoma mansoni chromatin regulatory protein sir2 0.0549 0.5883 0.5883
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0042 0.0325 0.0332
Giardia lamblia DINP protein human, muc B family 0.006 0.0522 0.0532
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.019 0.0194
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.1704 0.1704
Loa Loa (eye worm) ShTK domain-containing protein 0.0389 0.4135 0.4222
Echinococcus granulosus microtubule associated protein 2 0.0679 0.7313 0.7466
Plasmodium falciparum thioredoxin reductase 0.01 0.0968 0.2826
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0399 0.4245 0.4333
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0027 0.016 0.0162
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.012 0.0051
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0122 0.0123
Loa Loa (eye worm) hypothetical protein 0.0549 0.5883 0.6007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0112 0.1095 0.1095
Loa Loa (eye worm) hypothetical protein 0.004 0.0311 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0122 0.0123
Schistosoma mansoni chromatin regulatory protein sir2 0.0324 0.3422 0.3422
Loa Loa (eye worm) heterochromatin protein 1 0.0142 0.1423 0.1453
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0311 0.0316
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0027 0.016 0.0463
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0306 0.0311
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0091 0.0867 0.0867
Entamoeba histolytica thioredoxin reductase, putative 0.0027 0.016 0.0162
Brugia malayi MH2 domain containing protein 0.0144 0.1449 0.1477
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0027 0.016 0.0162
Mycobacterium ulcerans flavoprotein disulfide reductase 0.01 0.0968 0.0932
Mycobacterium ulcerans hypothetical protein 0.0054 0.0456 0.04
Echinococcus multilocularis chromobox protein 1 0.0142 0.1423 0.1452
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0027 0.016 0.0463
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.019 0.0552
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0054 0.0456 0.04
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0542 0.0552
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0122 0.0123
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0041 0.0115
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0218 0.2262 0.2308
Leishmania major phosphoglycerate kinase C, glycosomal 0.0167 0.1704 0.1738
Trypanosoma brucei unspecified product 0.0041 0.0319 0.0324
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0122 0.0353
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0968 0.0987
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.016 0.0162
Schistosoma mansoni chromobox protein 0.0142 0.1423 0.1423
Schistosoma mansoni sulfide quinone reductase 0.0027 0.016 0.016
Loa Loa (eye worm) tyrosinase 1 0.0389 0.4135 0.4222
Trichomonas vaginalis mercuric reductase, putative 0.01 0.0968 0.0987
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0027 0.016 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0523 0.0469
Echinococcus granulosus bloom syndrome protein 0.0024 0.0127 0.0128
Echinococcus granulosus chromobox protein 2 0.0023 0.0122 0.0123
Plasmodium falciparum phosphoglycerate kinase 0.0167 0.1704 0.4977
Brugia malayi Protein cec-1. 0.0023 0.0122 0.0123
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.0542 0.0552
Schistosoma mansoni jumonji domain containing protein 0.0237 0.2469 0.2469
Loa Loa (eye worm) programmed cell death 8 0.0027 0.016 0.0163
Loa Loa (eye worm) hypothetical protein 0.0167 0.1704 0.174
Echinococcus multilocularis cpg binding protein 0.003 0.0195 0.0198
Mycobacterium tuberculosis Conserved hypothetical protein 0.006 0.0522 0.0516
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0456 0.0464
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0071 0.0202
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.058 0.0592
Echinococcus multilocularis expressed protein 0.0787 0.8498 0.8676
Mycobacterium ulcerans dehydrogenase 0.0027 0.016 0.0092
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0522 0.0469
Echinococcus multilocularis thioredoxin glutathione reductase 0.029 0.3049 0.3111
Loa Loa (eye worm) transcriptional regulator 0.0218 0.2262 0.231
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0027 0.016 0.0162
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.0522 0.0532
Brugia malayi Thioredoxin reductase 0.029 0.3043 0.3106
Trypanosoma brucei polo-like protein kinase 0.0399 0.4245 0.4333
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0485 0.0494
Loa Loa (eye worm) hypothetical protein 0.0058 0.0509 0.0519
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0027 0.016 0.0162
Plasmodium vivax hypothetical protein, conserved 0.0091 0.0867 0.2531
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.2035 0.2076
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0042 0.0325 0.033

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0032 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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