Detailed information for compound 1305096

Basic information

Technical information
  • TDR Targets ID: 1305096
  • Name: N-ethyl-2-(4-ethylphenoxy)acetamide
  • MW: 207.269 | Formula: C12H17NO2
  • H donors: 1 H acceptors: 1 LogP: 2.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=O)COc1ccc(cc1)CC
  • InChi: 1S/C12H17NO2/c1-3-10-5-7-11(8-6-10)15-9-12(14)13-4-2/h5-8H,3-4,9H2,1-2H3,(H,13,14)
  • InChiKey: RQOHJCMOXBDSST-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-ethyl-2-(4-ethylphenoxy)ethanamide
  • MLS000662802
  • SMR000270262
  • ZINC04833519
  • STK225315

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0013 0.0077
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0013 0.0054
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.004 0.0048
Brugia malayi nuclear receptor RXR 0.0016 0.0003 0.0019
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.004 0.1882
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0039 0.1313
Brugia malayi conserved hypotetical protein 0.0016 0.0003 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0039 0.0258
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0191
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0003 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0039 0.0246
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0003 0.0003
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0055 0.0068
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Schistosoma mansoni hypothetical protein 0.0125 0.0222 0.1416
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.004 0.004
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0015 0.0564
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0039 0.0246
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0013 0.0081
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0017 0.0044
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0013 0.0666
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0115
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0039 0.0258
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.004 0.2106
Loa Loa (eye worm) glutaminase 2 0.0533 0.1041 0.6992
Schistosoma mansoni nuclear receptor 0.0016 0.0003 0.0018
Schistosoma mansoni cpg binding protein 0.0059 0.009 0.057
Brugia malayi intermediate filament protein 0.0058 0.0089 0.059
Loa Loa (eye worm) DR-78 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Echinococcus multilocularis GPCR, family 2 0.0099 0.017 0.0169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0003 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0039 0.0258
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0051 0.0373
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0003 0.0018
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.004 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0099 0.017 0.0169
Brugia malayi MH2 domain containing protein 0.0052 0.0075 0.0499
Schistosoma mansoni smad 0.0023 0.0018 0.011
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0039 0.1313
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0003 0.0095
Brugia malayi MH2 domain containing protein 0.0052 0.0075 0.0499
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0192 0.1358
Schistosoma mansoni cpg binding protein 0.0059 0.009 0.057
Schistosoma mansoni ap endonuclease 0.0023 0.0017 0.0106
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0017 0.0044
Schistosoma mansoni hypothetical protein 0.0794 0.1566 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0191
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0192 0.1219
Brugia malayi hypothetical protein 0.0253 0.048 0.3219
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0246 0.1568
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0039 0.0258
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0003 0.0019
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0093 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Plasmodium falciparum glutathione reductase 0.0034 0.004 0.2129
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0254 0.1619
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Brugia malayi hypothetical protein 0.0016 0.0003 0.0019
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.048 0.3061
Brugia malayi hypothetical protein 0.0018 0.0007 0.0044
Brugia malayi beta-lactamase 0.011 0.0192 0.1282
Toxoplasma gondii thioredoxin reductase 0.0099 0.017 0.0228
Brugia malayi nuclear receptor NHR-88 0.0034 0.0039 0.0258
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0013 0.0077
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0015 0.0499
Echinococcus multilocularis dna polymerase eta 0.002 0.0013 0.0012
Brugia malayi beta-lactamase family protein 0.011 0.0192 0.1282
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.004 0.0268
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.017 0.12
Echinococcus multilocularis thioredoxin glutathione reductase 0.0099 0.0171 0.017
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0003 0.0018
Brugia malayi Latrophilin receptor protein 2 0.0099 0.017 0.1138
Trypanosoma brucei trypanothione reductase 0.0099 0.017 0.8869
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0039 0.0258
Brugia malayi MH2 domain containing protein 0.0023 0.0018 0.0115
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0089 0.059
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0048 0.9136
Schistosoma mansoni DNA polymerase eta 0.002 0.0013 0.0077
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0189
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0039 0.0246
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0006 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0093 0.0776
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0013 0.04
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0039 0.0038
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0013 0.04
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0192 0.0191
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0075 0.0501
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0013 0.0054
Mycobacterium ulcerans hypothetical protein 0.011 0.0192 0.1738
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0312 0.0599 0.4018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Mycobacterium leprae Probable lipase LipE 0.011 0.0192 0.3649
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0017 0.0044
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.1313 0.1313
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0051 0.0322
Mycobacterium ulcerans lipase LipD 0.011 0.0192 0.1738
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0039 0.0258
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0052 0.0075 0.0475
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0039 0.0246
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.004 1
Echinococcus multilocularis neuropeptide receptor 0.0487 0.0948 0.0948
Onchocerca volvulus 0.011 0.0192 0.6518
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0003 0.0003
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0034 0.0226
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0159
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0003 0.0019
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0225 0.0424 0.3052
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0022 0.0144
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.004 0.2106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0003 0.0018
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.004 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0039 0.0258
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0017 0.0017
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0397 0.0769 0.516
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0007 0.0044
Brugia malayi nuclear receptor RXR 0.0018 0.0007 0.0044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0017 0.0641
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0039 0.0246
Brugia malayi tailless protein 0.0016 0.0003 0.0019
Schistosoma mansoni coup transcription factor 0.0034 0.0039 0.0246
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0003 0.0019
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.0018 0.011
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.017 0.8837
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Toxoplasma gondii ABC1 family protein 0.011 0.0192 0.0258
Leishmania major DNA polymerase eta, putative 0.002 0.0013 0.04
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.246
Mycobacterium tuberculosis Probable oxidoreductase 0.025 0.0474 0.342
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0039 0.0258
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0039 0.0258
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0029 0.0627
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0048 0.1344
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0051 0.0322
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0039 0.0246
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0051 0.0322
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.017
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0089 0.059
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0039 0.0246
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.004 0.0268
Schistosoma mansoni hypothetical protein 0.0214 0.04 0.2553
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0003 0.0019
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0003 0.0095
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.0075 0.0499
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0039 0.0246
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0048 0.2582
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.004 0.0268
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0192 0.1358
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0029 0.0174
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0003 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Loa Loa (eye worm) hypothetical protein 0.0253 0.048 0.3219
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0222 0.1416
Loa Loa (eye worm) hypothetical protein 0.018 0.0334 0.2237
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0225 0.0424 0.3052
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Echinococcus granulosus cpg binding protein 0.0059 0.009 0.057
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0051 0.246
Loa Loa (eye worm) hypothetical protein 0.0312 0.0599 0.4018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.004 0.0048
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0003 0.0018
Schistosoma mansoni hypothetical protein 0.0052 0.0075 0.0477
Onchocerca volvulus 0.0052 0.0075 0.2548
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0254 0.0253
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0018 0.0115
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0192 0.1282
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0007 0.0042
Leishmania major DNA polymerase kappa, putative 0.002 0.0013 0.04
Echinococcus multilocularis geminin 0.054 0.1055 0.1055
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.0018 0.011
Echinococcus granulosus TGF beta signal transducer SmadC 0.0052 0.0075 0.0475
Mycobacterium tuberculosis Conserved protein 0.011 0.0192 0.1358
Mycobacterium tuberculosis Conserved protein 0.011 0.0192 0.1358
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0051 0.005
Brugia malayi ecdysteroid receptor 0.0034 0.0039 0.0258
Brugia malayi glutathione reductase 0.0099 0.017 0.1137
Schistosoma mansoni Smad4 0.0023 0.0018 0.011
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0055 0.2653
Brugia malayi ecdysone receptor 0.0016 0.0003 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0007 0.0044
Echinococcus granulosus dnaJ subfamily B 0.0794 0.1566 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.004 0.2129
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0039 0.0258
Schistosoma mansoni smad1 5 8 and 0.0052 0.0075 0.0475
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.3619 0.7236 1
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0192 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0051 0.0339
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0039 0.0246
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0055 0.0408
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0192 0.1358
Mycobacterium ulcerans hypothetical protein 0.0029 0.0029 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0666
Leishmania major hypothetical protein, conserved 0.011 0.0192 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0007 0.0042
Loa Loa (eye worm) glutaminase 0.0533 0.1041 0.6992
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Brugia malayi nuclear hormone receptor 0.0016 0.0003 0.0019
Brugia malayi MH1 domain containing protein 0.0052 0.0075 0.0499
Echinococcus granulosus dna polymerase eta 0.002 0.0013 0.0077
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0039 0.0246
Echinococcus multilocularis tar DNA binding protein 0.0397 0.0769 0.0768
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.1138
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0051 0.0373
Schistosoma mansoni glutaminase 0.0533 0.1041 0.6649
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0003 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.004 0.0253
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Echinococcus multilocularis Smad4 0.0052 0.0075 0.0074
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.017 0.1138
Plasmodium vivax hypothetical protein, conserved 0.011 0.0192 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0039 0.0246
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0039 0.0246
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0017 0.0172
Schistosoma mansoni cpg binding protein 0.0056 0.0084 0.053
Brugia malayi nuclear hormone receptor 0.0034 0.0039 0.0258
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0005 0.0277
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0192 0.1738
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Treponema pallidum NADH oxidase 0.0034 0.004 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0051 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0192 0.1219
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0013 0.0077
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0003 0.0018
Echinococcus granulosus GPCR family 2 0.0099 0.017 0.1082
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0006 0.0036
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.004 0.2106
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.004 0.0253
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0052 0.0075 0.0074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0225 0.0424 0.3052
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.1278
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0039 0.1313
Echinococcus multilocularis mothers against decapentaplegic 5 0.0052 0.0075 0.0074
Brugia malayi MH2 domain containing protein 0.0756 0.1489 1
Mycobacterium tuberculosis Conserved protein 0.011 0.0192 0.1358
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0099 0.017 0.1082
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Mycobacterium tuberculosis Possible penicillin-binding protein 0.07 0.1377 1
Brugia malayi hypothetical protein 0.0016 0.0003 0.0019
Brugia malayi MH1 domain containing protein 0.0028 0.0029 0.0189
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0093 0.0776
Echinococcus granulosus Smad4 0.0052 0.0075 0.0475
Brugia malayi Thioredoxin reductase 0.0099 0.017 0.1137
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.004 0.2129
Echinococcus multilocularis cpg binding protein 0.0059 0.009 0.0089
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0039 0.0246
Schistosoma mansoni smad1 5 8 and 0.0052 0.0075 0.0475
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0051 0.0322
Schistosoma mansoni Smad4 0.0052 0.0075 0.0475
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0081
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0225 0.0424 0.8867
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.004 0.0256
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.025 0.0474 0.342
Onchocerca volvulus 0.0029 0.0029 0.097
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0055 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0003 0.0019
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.0018 0.0017
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0191 0.0256
Loa Loa (eye worm) TAR-binding protein 0.0397 0.0769 0.516
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0756 0.1489 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.004 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0039 0.0258
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0191
Onchocerca volvulus 0.016 0.0293 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Brugia malayi RNA binding protein 0.0397 0.0769 0.516
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0192 0.1358
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Onchocerca volvulus 0.0058 0.0089 0.3001
Brugia malayi MH1 domain containing protein 0.0028 0.0029 0.0189
Echinococcus granulosus mothers against decapentaplegic 5 0.0052 0.0075 0.0475
Brugia malayi RNA recognition motif domain containing protein 0.0397 0.0769 0.516
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0029 0.0159
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Echinococcus granulosus intermediate filament protein 0.0058 0.0089 0.0561
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0192 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0029 0.0627
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Schistosoma mansoni smad 0.0052 0.0075 0.0475
Loa Loa (eye worm) hypothetical protein 0.0058 0.0089 0.059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0241 0.0454 0.3049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0039 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.246
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0039 0.0258
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0007 0.0044
Brugia malayi TAR-binding protein 0.0397 0.0769 0.516
Echinococcus multilocularis muscleblind protein 0.018 0.0334 0.0333
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0017 0.0641
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Loa Loa (eye worm) nuclear factor I 0.0028 0.0029 0.0189
Brugia malayi steroid hormone receptor 0.0034 0.0039 0.0258
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0241 0.0454 0.3049
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0192 0.1282
Schistosoma mansoni smad1 5 8 and 0.0052 0.0075 0.0475
Schistosoma mansoni hypothetical protein 0.054 0.1055 0.6738
Echinococcus granulosus neuropeptide receptor 0.0487 0.0948 0.6054
Schistosoma mansoni intermediate filament proteins 0.0058 0.0089 0.0561
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0017 0.0641
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0039 0.0038
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0003 0.0018
Loa Loa (eye worm) transcription factor SMAD2 0.0756 0.1489 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Toxoplasma gondii exonuclease III APE 0.0023 0.0017 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0192 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.2669
Mycobacterium ulcerans glutaminase 0.0533 0.1041 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0015 0.0018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Plasmodium falciparum thioredoxin reductase 0.0034 0.004 0.2129
Trichomonas vaginalis esterase, putative 0.011 0.0192 0.1738
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0093 0.4687
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0093 0.0776
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0225 0.0424 0.3052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0039 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0039 0.0258
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0013 0.0081
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0017 0.0111
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0051 0.0322
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.004 0.7193
Echinococcus granulosus tar DNA binding protein 0.0397 0.0769 0.4906
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0039 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.017 0.0169
Schistosoma mansoni ap endonuclease 0.0023 0.0017 0.0106
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0005 0.0005
Plasmodium falciparum thioredoxin reductase 0.0099 0.017 1
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0192 0.1738
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0013 0.0012
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0093 0.0121
Loa Loa (eye worm) glutathione reductase 0.0099 0.017 0.1137
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0017 0.0725
Trypanosoma brucei unspecified product 0.002 0.0013 0.0666
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0018 0.0115
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0029 0.0159
Brugia malayi nuclear receptor NHR-67 0.0016 0.0003 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0159 0.029 0.1848
Loa Loa (eye worm) beta-lactamase 0.011 0.0192 0.1282
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0039 0.0246
Echinococcus granulosus geminin 0.054 0.1055 0.6738
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0003 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.0454 0.0454
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0028 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0039 0.0258
Echinococcus multilocularis G protein coupled receptor 139 0.0487 0.0948 0.0948
Plasmodium vivax glutathione reductase, putative 0.0099 0.017 0.8837
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.004 0.0268
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0051 0.005
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.0018 0.0017
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.004 0.1882
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0039 0.0258
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0191
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.1278
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.017 0.8837
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0184
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0089 0.059
Schistosoma mansoni hypothetical protein 0.015 0.0273 0.1743
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0339
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0005 0.0031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0039 0.0258
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0029 0.0159
Brugia malayi isocitrate dehydrogenase 0.0017 0.0005 0.0031
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0039 0.0246
Echinococcus multilocularis dnaJ subfamily B 0.0794 0.1566 0.1565
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0192 0.1738
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.1278
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.004 0.0266
Onchocerca volvulus 0.011 0.0192 0.6518
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.048 0.0479
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0017 0.09
Loa Loa (eye worm) hypothetical protein 0.018 0.0334 0.2237
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0022 0.0144
Schistosoma mansoni lamin 0.0058 0.0089 0.0561
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0039 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0159
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0192 0.1738
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0039 0.0258
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Echinococcus multilocularis musashi 0.0058 0.0089 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0039 0.0038
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0003 0.0018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0006 0.0006
Echinococcus multilocularis lamin 0.0058 0.0089 0.0088
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0007 0.0042
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0006 0.0038
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0051 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0093 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0039 0.0258
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0017 0.0641
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0192 0.1358
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0039 0.0038
Brugia malayi Smad1 0.0052 0.0075 0.0499
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.004 0.1882
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0055 0.0408
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.004 0.1882
Echinococcus granulosus smad 0.0052 0.0075 0.0475
Brugia malayi hypothetical protein 0.016 0.0293 0.1967
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0084 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0039 0.0258
Echinococcus granulosus muscleblind protein 0.018 0.0334 0.2127
Echinococcus multilocularis lamin dm0 0.0058 0.0089 0.0088
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0254 0.1703
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0312 0.0599 0.4018
Onchocerca volvulus 0.0016 0.0003 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.0454 0.2899
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0666
Onchocerca volvulus 0.0034 0.0039 0.1313
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Echinococcus granulosus thioredoxin glutathione reductase 0.0099 0.0171 0.1088
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.004 0.1882
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Loa Loa (eye worm) hypothetical protein 0.0214 0.04 0.2685
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0454 0.2899
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0093 0.0587
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0005 0.0031
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.004 0.2106
Schistosoma mansoni lamin 0.0058 0.0089 0.0561
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0029 0.0627
Mycobacterium leprae conserved hypothetical protein 0.011 0.0192 0.3649
Brugia malayi Calcitonin receptor-like protein seb-1 0.0312 0.0599 0.4018
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0093 0.0637
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0191
Schistosoma mansoni transcription factor LCR-F1 0.015 0.0273 0.1743
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.016 0.0293 0.1967
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0007 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0039 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0159
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.017 0.1082
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0192 0.1738
Brugia malayi beta-lactamase family protein 0.011 0.0192 0.1282
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0039 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0003 0.0003
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0023 0.0018 0.0586
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0017 0.0111
Echinococcus multilocularis dna polymerase kappa 0.002 0.0013 0.0012
Mycobacterium ulcerans beta-lactamase 0.011 0.0192 0.1738
Echinococcus granulosus lamin dm0 0.0058 0.0089 0.0561
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0029 0.0159
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.029 0.0289
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.0018 0.0115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.0454 0.0454
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0005 0.0005
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0003 0.0018
Echinococcus granulosus lamin 0.0058 0.0089 0.0561
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0005 0.0277
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.025 0.0474 1
Onchocerca volvulus 0.0056 0.0084 0.2831
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.0273 0.0273
Schistosoma mansoni hypothetical protein 0.054 0.1055 0.6738
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.0273 0.1743
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.004 0.1882
Schistosoma mansoni survival motor neuron protein 0.0052 0.0075 0.0477
Brugia malayi latrophilin 2 splice variant baaae 0.0214 0.04 0.2685
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.0075 0.0499
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0039 0.0038
Brugia malayi Muscleblind-like protein 0.018 0.0334 0.2237
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0015 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0029 0.0174
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0192 0.1738
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Plasmodium falciparum glutathione reductase 0.0099 0.017 1
Brugia malayi CXXC zinc finger family protein 0.0056 0.0084 0.0557
Trichomonas vaginalis glutaminase, putative 0.0533 0.1041 1
Brugia malayi hypothetical protein 0.0018 0.0007 0.0044
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0034 0.0226
Mycobacterium tuberculosis Probable reductase 0.0225 0.0424 0.3052
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0192 0.1358
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.1313 0.8385
Schistosoma mansoni Smad4 0.0023 0.0018 0.011
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0029
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0028 0.0175
Loa Loa (eye worm) RNA binding protein 0.0397 0.0769 0.516
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0039 0.0246
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0013 0.0081
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0576
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0192 0.1219
Brugia malayi hypothetical protein 0.015 0.0273 0.1833
Loa Loa (eye worm) acetyltransferase 0.0141 0.0254 0.1703
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.017 0.1138
Mycobacterium tuberculosis Probable dehydrogenase 0.0225 0.0424 0.3052
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0051 0.1471
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0017 0.0087
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.025 0.0474 0.342
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0051 0.005
Schistosoma mansoni neuropeptide receptor 0.0487 0.0948 0.6054
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0005
Brugia malayi MH1 domain containing protein 0.0052 0.0075 0.0499
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0005 0.0029
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.017 0.1137
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.0454 0.2899
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0039 0.0258
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Onchocerca volvulus 0.011 0.0192 0.6518
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0118 0.0209 0.1331
Echinococcus granulosus microtubule associated protein 2 0.0668 0.1313 0.8385
Onchocerca volvulus 0.0016 0.0003 0.0095
Echinococcus granulosus dna polymerase kappa 0.002 0.0013 0.0077
Schistosoma mansoni zinc finger protein 0.0016 0.0003 0.0018
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.004 0.1882
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0055 0.0345
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0454 0.2899
Brugia malayi glutaminase DH11.1 0.0533 0.1041 0.6992
Onchocerca volvulus 0.0058 0.0089 0.3001
Echinococcus multilocularis smad 0.0052 0.0075 0.0074
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0017 0.0106
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0093 0.0587
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0192 0.1358
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Leishmania major trypanothione reductase 0.0099 0.017 0.8837
Schistosoma mansoni nuclear receptor 0.0016 0.0003 0.0018
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0003 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0159 0.029 0.1848
Echinococcus multilocularis muscleblind protein 1 0.018 0.0334 0.0333
Brugia malayi nuclear receptor NHR-88 0.0016 0.0003 0.0019
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0003 0.0019
Loa Loa (eye worm) Smad1 0.0052 0.0075 0.0499
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0222 0.0222
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0666
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0192 0.1738
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0017 0.1167
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0039 0.0258
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0454 0.2899

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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