Detailed information for compound 1305982

Basic information

Technical information
  • TDR Targets ID: 1305982
  • Name: ethyl 2-(cyanoamino)-4-(4-hydroxyphenyl)-5,6- dimethyl-4H-pyran-3-carboxylate
  • MW: 314.336 | Formula: C17H18N2O4
  • H donors: 2 H acceptors: 3 LogP: 3.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(NC#N)OC(=C(C1c1ccc(cc1)O)C)C
  • InChi: 1S/C17H18N2O4/c1-4-22-17(21)15-14(12-5-7-13(20)8-6-12)10(2)11(3)23-16(15)19-9-18/h5-8,14,19-20H,4H2,1-3H3
  • InChiKey: UUPXNJLFTSBKPN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(cyanoamino)-4-(4-hydroxyphenyl)-5,6-dimethyl-4H-pyran-3-carboxylic acid ethyl ester
  • STOCK2S-67172
  • MLS000038330
  • SMR000041023

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine proteinase, putative 0.0103 0.0542 0.2037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0073 0.0508
Brugia malayi cathepsin L-like cysteine proteinase 0.0045 0.0181 0.0678
Leishmania major DNA polymerase kappa, putative 0.0019 0.002 0.0182
Loa Loa (eye worm) hypothetical protein 0.0045 0.0181 0.0477
Leishmania major cathepsin L-like protease 0.0188 0.1073 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0136 0.1109
Onchocerca volvulus 0.0188 0.1073 1
Schistosoma mansoni patched 1 0.0051 0.0219 0.058
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.02 0.0529
Trypanosoma cruzi cruzipain precursor, putative 0.0188 0.1073 0.4029
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0045 0.0181 0.1528
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.003 0.0079
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0144 0.1179
Entamoeba histolytica cysteine proteinase 1, putative 0.0103 0.0542 0.4963
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0168 0.0949 0.8816
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0333 0.2979
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0443 0.2664 0.7036
Brugia malayi Papain family cysteine protease containing protein 0.0188 0.1073 0.4029
Schistosoma mansoni bromodomain containing protein 0.0076 0.0378 0.0997
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0136 0.127
Loa Loa (eye worm) hypothetical protein 0.0045 0.0181 0.0477
Schistosoma mansoni hypothetical protein 0.0513 0.3099 0.8185
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0169 0.1579
Brugia malayi Cathepsin L-like precursor 0.013 0.0711 0.2671
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0219 0.058
Schistosoma mansoni hypothetical protein 0.0299 0.1763 0.4657
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0045 0.0181 0.0477
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0136 0.0512
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.1073 0.4029
Brugia malayi mbt repeat family protein 0.0048 0.02 0.0751
Loa Loa (eye worm) hypothetical protein 0.0181 0.1031 0.2723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0103 0.0542 0.4963
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0062 0.0291 0.0769
Trypanosoma cruzi cysteine peptidase, putative 0.0103 0.0542 0.2037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Plasmodium falciparum serine repeat antigen 7 0.0045 0.0181 0.1682
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.002 0.1433
Schistosoma mansoni hypothetical protein 0.0025 0.0057 0.015
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0241 0.0241
Echinococcus granulosus cathepsin L 0.0045 0.0181 0.0477
Plasmodium vivax unspecified product 0.0045 0.0181 0.1682
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0188 0.1073 1
Leishmania major cathepsin L-like protease 0.0188 0.1073 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0144 0.1179
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0136 0.1109
Giardia lamblia Cathepsin L precursor 0.0045 0.0181 0.1733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0181 0.1528
Entamoeba histolytica cysteine protease, putative 0.0188 0.1073 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0168 0.0949 0.8837
Echinococcus multilocularis zinc finger protein 0.0024 0.0049 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0475 0.0475
Giardia lamblia Cathepsin B precursor 0.0045 0.0181 0.1733
Plasmodium falciparum importin beta, putative 0.0058 0.0266 0.2474
Plasmodium vivax vivapain-2 0.0188 0.1073 1
Giardia lamblia Cysteine protease 0.0045 0.0181 0.1733
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0475 0.1255
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0168 0.0949 0.3561
Schistosoma mansoni cathepsin C 0.0045 0.0181 0.0477
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0181 0.0678
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0188 0.1073 0.2835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.013 0.0711 0.6565
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0172 0.0454
Trichomonas vaginalis ran, putative 0.0043 0.0169 0.1423
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.1073 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0475 0.1255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0181 0.1528
Giardia lamblia Cathepsin B precursor 0.0045 0.0181 0.1733
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.1073 1
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.02 0.0529
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.003 0.0079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0475 0.1784
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0181 0.1528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0475 0.1255
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0182
Loa Loa (eye worm) hypothetical protein 0.0052 0.0222 0.0588
Brugia malayi cathepsin Z-like cysteine proteinase 0.0045 0.0181 0.0678
Giardia lamblia Cathepsin L precursor 0.0045 0.0181 0.1733
Trypanosoma cruzi ISWI complex protein 0.0018 0.0017 0.0063
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0045 0.0181 0.1682
Echinococcus multilocularis snurportin 1 0.0624 0.3786 0.3786
Giardia lamblia Hypothetical protein 0.0045 0.0181 0.1733
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.1073 1
Giardia lamblia Cathepsin B precursor 0.0045 0.0181 0.1733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0045 0.0181 0.1682
Entamoeba histolytica cysteine protease, putative 0.0045 0.0181 0.1528
Plasmodium vivax vivapain-2 0.0188 0.1073 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0642 0.5908
Loa Loa (eye worm) hypothetical protein 0.0051 0.0219 0.058
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0181 0.0477
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0136 0.1257
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0181 0.0477
Giardia lamblia Cathepsin L precursor 0.0045 0.0181 0.1733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0181 0.1528
Giardia lamblia Cathepsin L-like protease 0.0045 0.0181 0.1733
Giardia lamblia Cysteine protease 0.0045 0.0181 0.1733
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0642 0.1696
Entamoeba histolytica Ran family GTPase 0.0043 0.0169 0.1423
Loa Loa (eye worm) hypothetical protein 0.0085 0.0434 0.1145
Onchocerca volvulus Cathepsin L homolog 0.0188 0.1073 1
Brugia malayi N-terminal motif family protein 0.0181 0.1031 0.3871
Entamoeba histolytica hypothetical protein 0.0047 0.0197 0.1681
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.002 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0103 0.0542 0.4963
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0169 0.0636
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.002 0.0052
Brugia malayi chromobox protein homolog 3 0.0039 0.0144 0.054
Giardia lamblia Cathepsin B precursor 0.0045 0.0181 0.1733
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0188 0.1073 1
Leishmania major cathepsin L-like protease 0.0188 0.1073 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0443 0.2664 1
Schistosoma mansoni cathepsin S (C01 family) 0.0045 0.0181 0.0477
Schistosoma mansoni ran 0.0043 0.0169 0.0448
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.003 0.003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0654 0.1726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0103 0.0542 0.5054
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0045 0.0181 0.1682
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0188 0.1073 0.1073
Schistosoma mansoni cathepsin F (C01 family) 0.0188 0.1073 0.2835
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0144 0.0533
Brugia malayi Bromodomain containing protein 0.0091 0.0466 0.1748
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0181 0.1528
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.003 0.0079
Brugia malayi Papain family cysteine protease containing protein 0.0103 0.0542 0.2037
Giardia lamblia Cathepsin L-like protease 0.0045 0.0181 0.1733
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.1073 1
Leishmania major cathepsin L-like protease 0.0188 0.1073 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0136 0.127
Echinococcus multilocularis dna polymerase kappa 0.0019 0.002 0.002
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.02 0.1106
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0045 0.0181 0.0477
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0073
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Loa Loa (eye worm) cathepsin B 0.0168 0.0949 0.2506
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.013 0.0711 0.2671
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0197 0.1681
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0169 0.1614
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0057 0.015
Toxoplasma gondii cathepsin CPC2 0.0045 0.0181 0.1682
Echinococcus granulosus dna polymerase eta 0.0019 0.002 0.0052
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0103 0.0542 0.1433
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0181 0.0477
Schistosoma mansoni zinc finger protein 0.0024 0.0049 0.0129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.1073 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0182
Entamoeba histolytica cysteine proteinase, putative 0.0188 0.1073 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0182
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0103 0.0542 0.2037
Brugia malayi Bromodomain containing protein 0.0046 0.019 0.0712
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0475 0.1255
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0045 0.0181 0.1733
Echinococcus multilocularis cathepsin L cysteine protease 0.0188 0.1073 0.1073
Brugia malayi Cathepsin L-like precursor 0.0188 0.1073 0.4029
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0241 0.0638
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0071 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Echinococcus multilocularis cathepsin L 0.0103 0.0542 0.0542
Trypanosoma cruzi major cysteine proteinase, putative 0.0045 0.0181 0.0678
Schistosoma mansoni ran 0.0043 0.0169 0.0448
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.096 0.2536
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0045 0.0181 0.1682
Brugia malayi Heterochromatin protein 1 0.0069 0.0333 0.1252
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0045 0.0181 0.0477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.1073 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0181 0.0477
Loa Loa (eye worm) hypothetical protein 0.0058 0.0264 0.0696
Leishmania major cathepsin L-like protease 0.0188 0.1073 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.0264 0.0264
Echinococcus granulosus chromobox protein 1 0.0069 0.0333 0.0881
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.02 0.0529
Echinococcus granulosus cathepsin l cysteine peptidase 0.0188 0.1073 0.2835
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0475 0.1255
Onchocerca volvulus 0.0188 0.1073 1
Brugia malayi Cathepsin L-like precursor 0.0188 0.1073 0.4029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Echinococcus granulosus cathepsin b 0.0443 0.2664 0.7036
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0351 0.0351
Echinococcus granulosus importin subunit beta 1 0.0058 0.0266 0.0701
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0169 0.1579
Plasmodium vivax vivapain-3 0.0103 0.0542 0.5054
Brugia malayi cathepsin L-like precursor 0.013 0.0711 0.2671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0181 0.1528
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Leishmania major cathepsin L-like protease 0.0188 0.1073 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Echinococcus multilocularis chromobox protein 1 0.0069 0.0333 0.0333
Leishmania major cathepsin L-like protease 0.0188 0.1073 1
Toxoplasma gondii cathepsin CPC1 0.0045 0.0181 0.1682
Echinococcus granulosus zinc finger protein 0.0024 0.0049 0.0129
Onchocerca volvulus 0.0188 0.1073 1
Schistosoma mansoni ap endonuclease 0.0038 0.0136 0.036
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0136 0.5
Brugia malayi fibroinase precursor 0.0045 0.0181 0.0678
Schistosoma mansoni cathepsin F (C01 family) 0.0188 0.1073 0.2835
Loa Loa (eye worm) MBCTL1 0.0055 0.0241 0.0638
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.0044
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.1125 0.1125
Schistosoma mansoni importin beta-1 0.0058 0.0266 0.0701
Trypanosoma brucei ISWI complex protein 0.0018 0.0017 0.0156
Entamoeba histolytica cysteine proteinase, putative 0.0103 0.0542 0.4963
Echinococcus granulosus cathepsin L cysteine proteinase 0.0188 0.1073 0.2835
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0642 0.2411
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0197 0.0739
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0045 0.0181 0.0477
Schistosoma mansoni cathepsin F (C01 family) 0.013 0.0711 0.1879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.1073 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0443 0.2664 0.7036
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0182
Plasmodium falciparum serine repeat antigen 3 0.0045 0.0181 0.1682
Loa Loa (eye worm) hypothetical protein 0.0058 0.0264 0.0696
Entamoeba histolytica cysteine proteinase, putative 0.0188 0.1073 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.002 0.002
Echinococcus granulosus cysteine protease 0.0103 0.0542 0.1433
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0333 0.2979
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0182
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0443 0.2664 1
Giardia lamblia Cathepsin L precursor 0.0045 0.0181 0.1733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.1073 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0168 0.0949 0.8837
Toxoplasma gondii exonuclease III APE 0.0038 0.0136 0.127
Echinococcus multilocularis cathepsin b 0.0443 0.2664 0.2664
Leishmania major hypothetical protein, conserved 0.0018 0.0017 0.0156
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0172 0.0172
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.1073 0.4029
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0045 0.0181 0.1682
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0351 0.0926
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0182
Onchocerca volvulus Cathepsin F homolog 0.0188 0.1073 1
Onchocerca volvulus 0.0188 0.1073 1
Schistosoma mansoni hypothetical protein 0.0049 0.0208 0.0549
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Echinococcus multilocularis cysteine protease 0.0188 0.1073 0.1073
Echinococcus granulosus cathepsin l1 0.0188 0.1073 0.2835
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.1073 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0136 0.0512
Trypanosoma cruzi ISWI complex protein 0.0018 0.0017 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.1073 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.1073 1
Schistosoma mansoni chromobox protein 0.0069 0.0333 0.0881
Echinococcus multilocularis cathepsin b 0.0443 0.2664 0.2664
Onchocerca volvulus 0.0188 0.1073 1
Echinococcus multilocularis cathepsin L 0.0045 0.0181 0.0181
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0266 0.2474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Trypanosoma cruzi cruzipain precursor, putative 0.0058 0.0264 0.099
Loa Loa (eye worm) hypothetical protein 0.0045 0.0181 0.0477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0136 0.0512
Giardia lamblia Cysteine protease 0.0045 0.0181 0.1733
Loa Loa (eye worm) hypothetical protein 0.013 0.0711 0.1879
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.002 0.0073
Plasmodium vivax vivapain-1 0.0103 0.0542 0.5054
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.002 0.1433
Loa Loa (eye worm) hypothetical protein 0.0048 0.02 0.0529
Leishmania major cysteine peptidase A (CPA) 0.0188 0.1073 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0045 0.0181 0.0678
Trypanosoma brucei unspecified product 0.0019 0.002 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.002 0.0182
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0168 0.0949 0.2506
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0045 0.0181 0.1682
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.002 0.002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0136 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.1073 1
Entamoeba histolytica cysteine protease, putative 0.0045 0.0181 0.1528
Entamoeba histolytica cysteine proteinase, putative 0.0103 0.0542 0.4963
Entamoeba histolytica cysteine protease, putative 0.0045 0.0181 0.1528
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0136 0.036
Plasmodium vivax unspecified product 0.0058 0.0264 0.2456
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0197 0.1681
Brugia malayi Cathepsin L-like precursor 0.013 0.0711 0.2671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0103 0.0542 0.5054
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0169 0.0448
Schistosoma mansoni ap endonuclease 0.0038 0.0136 0.036
Echinococcus granulosus snurportin 1 0.0624 0.3786 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0188 0.1073 1
Giardia lamblia Encystation-specific protease 0.0045 0.0181 0.1733
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0188 0.1073 0.2835
Leishmania major cathepsin L-like protease 0.0188 0.1073 1
Brugia malayi Cathepsin L-like precursor 0.0188 0.1073 0.4029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0181 0.1528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0181 0.1528
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0443 0.2664 0.7036
Brugia malayi Papain family cysteine protease containing protein 0.0103 0.0542 0.2037
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Entamoeba histolytica cysteine proteinase 2 0.0103 0.0542 0.4963
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0079
Brugia malayi cathepsin F-like cysteine proteinase 0.0045 0.0181 0.0678
Schistosoma mansoni hypothetical protein 0.0049 0.0208 0.0549
Entamoeba histolytica cysteine protease, putative 0.0045 0.0181 0.1528
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Plasmodium vivax importin-beta 2, putative 0.0058 0.0266 0.2474
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.002 0.0182
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0073
Onchocerca volvulus Cathepsin L homolog 0.0045 0.0181 0.0907
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0181 0.0477
Plasmodium falciparum serine repeat antigen 1 0.0045 0.0181 0.1682
Leishmania major importin beta-1 subunit, putative 0.0047 0.0197 0.1833
Giardia lamblia Cathepsin L precursor 0.0045 0.0181 0.1733
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0045 0.0181 0.1682
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0241 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.1073 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0045 0.0181 0.1682
Brugia malayi PHD-finger family protein 0.003 0.0089 0.0334
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0045 0.0181 0.1528
Echinococcus granulosus dna polymerase kappa 0.0019 0.002 0.0052
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0162 0.1353
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0035 0.0091
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0136 0.127
Trypanosoma cruzi major cysteine proteinase, putative 0.0045 0.0181 0.0678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.1073 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.003 0.0079
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0219 0.058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.1073 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.02 0.02
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0045 0.0181 0.1682
Giardia lamblia Cathepsin B precursor 0.0045 0.0181 0.1733
Brugia malayi mbt repeat family protein 0.0048 0.02 0.0751
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0181 0.0477
Brugia malayi CHE-14 protein 0.0051 0.0219 0.0824
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0045 0.0181 0.1528
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0241 0.0638
Loa Loa (eye worm) hypothetical protein 0.003 0.0091 0.0242
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0169 0.0169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0475 0.1255
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0136 0.0136
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.1073 0.4029
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.002 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0182
Schistosoma mansoni cathepsin B (C01 family) 0.0045 0.0181 0.0477
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0169 0.0636
Loa Loa (eye worm) hypothetical protein 0.0045 0.0181 0.0477
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0162 0.072
Plasmodium falciparum cysteine proteinase falcipain 1 0.0103 0.0542 0.5054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0181 0.1528
Brugia malayi Cathepsin L-like precursor 0.0188 0.1073 0.4029
Echinococcus multilocularis cathepsin L cysteine protease 0.0188 0.1073 0.1073
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0136 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0443 0.2664 0.7036
Onchocerca volvulus Cathepsin L homolog 0.0188 0.1073 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0241 0.0638
Giardia lamblia Cathepsin B precursor 0.0168 0.0949 1
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.02 0.0529
Echinococcus multilocularis chromobox protein 1 0.0069 0.0333 0.0333
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0181 0.0678
Loa Loa (eye worm) hypothetical protein 0.0045 0.0181 0.0477
Brugia malayi Cathepsin L-like precursor 0.0188 0.1073 0.4029
Loa Loa (eye worm) hypothetical protein 0.013 0.0711 0.1879
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0045 0.0181 0.1733
Plasmodium falciparum serine repeat antigen 8 0.0045 0.0181 0.1682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Leishmania major GTP-binding protein, putative 0.0043 0.0169 0.1579
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0045 0.0181 0.1733
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0045 0.0181 0.1528
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0181 0.1528
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Echinococcus granulosus expressed conserved protein 0.0112 0.0597 0.1578
Echinococcus granulosus cathepsin L 0.0103 0.0542 0.1433
Loa Loa (eye worm) hypothetical protein 0.0045 0.0181 0.0477
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0475 0.0475
Schistosoma mansoni hypothetical protein 0.0049 0.0208 0.0549
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.002 0.0073
Toxoplasma gondii preprocathepsin c precursor, putative 0.0045 0.0181 0.1682
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0169 0.0448
Trypanosoma cruzi cysteine protease, putative 0.0103 0.0542 0.2037
Brugia malayi cathepsin L precursor 0.0045 0.0181 0.0678
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.003 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0073 0.0508
Brugia malayi RNA, U transporter 1 0.0166 0.0936 0.3515
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0264 0.099
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0071 0.0188
Onchocerca volvulus 0.013 0.0711 0.6314
Giardia lamblia Cathepsin B precursor 0.0168 0.0949 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.002 0.0182
Echinococcus granulosus cathepsin b 0.0443 0.2664 0.7036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.013 0.0711 0.6565
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0058 0.0264 0.099
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0181 0.1528
Loa Loa (eye worm) hypothetical protein 0.0188 0.1073 0.2835
Plasmodium vivax unspecified product 0.0103 0.0542 0.5054
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0162 0.1353
Brugia malayi cathepsin F-like cysteine proteinase 0.0058 0.0264 0.099
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.002 0.0182
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0045 0.0181 0.1682
Schistosoma mansoni hypothetical protein 0.0624 0.3786 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0045 0.0181 0.1682
Loa Loa (eye worm) hypothetical protein 0.0058 0.0264 0.0696
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0624 0.3786 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.013 0.0711 0.2671
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0219 0.0219
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0045 0.0181 0.1682
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0241 0.0906
Loa Loa (eye worm) hypothetical protein 0.0119 0.0642 0.1696
Plasmodium falciparum serine repeat antigen 9 0.0045 0.0181 0.1682
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0073
Onchocerca volvulus 0.0048 0.02 0.1106
Loa Loa (eye worm) hypothetical protein 0.0058 0.0266 0.0701
Brugia malayi Importin beta-1 subunit 0.0058 0.0266 0.0997
Onchocerca volvulus 0.0188 0.1073 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0103 0.0542 0.1433
Echinococcus multilocularis cysteine protease 0.0188 0.1073 0.1073
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0136 0.1109
Leishmania major DNA polymerase eta, putative 0.0019 0.002 0.0182
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.002 0.0052
Loa Loa (eye worm) hypothetical protein 0.0443 0.2664 0.7036
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.1073 0.4029
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0169 0.1579
Schistosoma mansoni chromobox protein 0.0069 0.0333 0.0881
Echinococcus granulosus cathepsin l1 0.013 0.0711 0.1879
Giardia lamblia Cathepsin B precursor 0.0168 0.0949 1
Schistosoma mansoni hypothetical protein 0.0049 0.0208 0.0549
Plasmodium falciparum serine repeat antigen 6 0.0045 0.0181 0.1682
Plasmodium falciparum serine repeat antigen 2 0.0045 0.0181 0.1682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0181 0.1528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.002 0.0182
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0333 0.0881
Onchocerca volvulus 0.0045 0.0181 0.0907
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.02 0.02
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.02 0.0529
Giardia lamblia Cathepsin L precursor 0.0045 0.0181 0.1733
Toxoplasma gondii cathepsin B 0.0168 0.0949 0.8837
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.003 0.0079
Loa Loa (eye worm) ctsf protein 0.0188 0.1073 0.2835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.1073 1
Loa Loa (eye worm) cysteine protease 0.0188 0.1073 0.2835
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0188 0.1073 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.1073 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0103 0.0542 0.1433
Brugia malayi Cathepsin L-like precursor 0.0188 0.1073 0.4029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0208 0.055
Plasmodium falciparum serine repeat antigen 5 0.0045 0.0181 0.1682
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0219 0.058
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0266 0.2474
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.1073 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0136 0.036
Entamoeba histolytica hypothetical protein 0.0045 0.0181 0.1528
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.1073 1
Giardia lamblia Hypothetical protein 0.0045 0.0181 0.1733
Loa Loa (eye worm) hypothetical protein 0.0055 0.0241 0.0638
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0181 0.0678
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0136 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0642 0.0642
Toxoplasma gondii cathepsin CPL 0.0188 0.1073 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0169 0.0636
Echinococcus granulosus geminin 0.0513 0.3099 0.8185
Entamoeba histolytica cysteine protease, putative 0.0045 0.0181 0.1528
Plasmodium vivax serine-repeat antigen (SERA) 0.0045 0.0181 0.1682
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0045 0.0181 0.1733
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0188 0.1073 0.1073
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0181 0.0477
Loa Loa (eye worm) hypothetical protein 0.013 0.0711 0.1879
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.1073 1
Giardia lamblia Cysteine protease 0.0045 0.0181 0.1733
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.1031 0.9569
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0045 0.0181 0.1682
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0181 0.1528
Brugia malayi Cathepsin L-like precursor 0.0058 0.0264 0.099
Schistosoma mansoni hypothetical protein 0.0513 0.3099 0.8185
Entamoeba histolytica cysteine proteinase, putative 0.013 0.0711 0.6565
Echinococcus granulosus cathepsin L cysteine protease 0.0103 0.0542 0.1433
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0181 0.1528
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0045 0.0181 0.0477
Echinococcus multilocularis geminin 0.0513 0.3099 0.3099
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0169 0.1579
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0058 0.0264 0.0696
Brugia malayi cathepsin Z-like cysteine proteinase 0.0045 0.0181 0.0678
Trypanosoma cruzi cysteine proteinase, putative 0.0103 0.0542 0.2037
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0045 0.0181 0.1528
Schistosoma mansoni cathepsin s 0.0058 0.0264 0.0696
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0181 0.1528
Echinococcus multilocularis protein patched 0.0051 0.0219 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.1073 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.002 0.0073
Echinococcus multilocularis expressed conserved protein 0.0112 0.0597 0.0597
Schistosoma mansoni zinc finger protein 0.0018 0.0017 0.0044
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.02 0.0529
Loa Loa (eye worm) fibroinase 0.0188 0.1073 0.2835
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.003 0.003
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0266 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0045 0.0181 0.1528
Entamoeba histolytica cysteine proteinase, putative 0.0103 0.0542 0.4963
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0219 0.1897
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.1125 0.2971
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0046 0.019 0.0503
Entamoeba histolytica cysteine proteinase, putative 0.0103 0.0542 0.4963
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0266 0.2474
Entamoeba histolytica cysteine protease, putative 0.0103 0.0542 0.4963
Onchocerca volvulus 0.0188 0.1073 1
Entamoeba histolytica cysteine protease, putative 0.0045 0.0181 0.1528
Plasmodium falciparum serine repeat antigen 4 0.0045 0.0181 0.1682
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0136 0.127
Echinococcus granulosus chromobox protein 1 0.0069 0.0333 0.0881
Schistosoma mansoni DNA polymerase eta 0.0019 0.002 0.0052
Plasmodium vivax serine-repeat antigen (SERA) 0.0045 0.0181 0.1682
Plasmodium falciparum cysteine proteinase falcipain 3 0.0188 0.1073 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0197 0.1681

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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