Detailed information for compound 1306287

Basic information

Technical information
  • TDR Targets ID: 1306287
  • Name: N-tert-butyl-2-[4-[2-methyl-5-(trifluoromethy l)benzimidazol-1-yl]piperidin-1-yl]acetamide
  • MW: 396.45 | Formula: C20H27F3N4O
  • H donors: 1 H acceptors: 2 LogP: 3.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(C)(C)C)CN1CCC(CC1)n1c(C)nc2c1ccc(c2)C(F)(F)F
  • InChi: 1S/C20H27F3N4O/c1-13-24-16-11-14(20(21,22)23)5-6-17(16)27(13)15-7-9-26(10-8-15)12-18(28)25-19(2,3)4/h5-6,11,15H,7-10,12H2,1-4H3,(H,25,28)
  • InChiKey: VXFBHQXGLMHZGX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-tert-butyl-2-[4-[2-methyl-5-(trifluoromethyl)benzimidazol-1-yl]-1-piperidyl]acetamide
  • N-tert-butyl-2-[4-[2-methyl-5-(trifluoromethyl)-1-benzimidazolyl]-1-piperidinyl]acetamide
  • N-tert-butyl-2-[4-[2-methyl-5-(trifluoromethyl)benzimidazol-1-yl]piperidin-1-yl]ethanamide
  • MLS000033677
  • N-tert-Butyl-2-[4-(2-methyl-5-trifluoromethyl-benzoimidazol-1-yl)-piperidin-1-yl]-acetamide
  • SMR000006462
  • ASN 06358644

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone deacetylase 0.0076 0.0331 0.0514
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0185 0.0291
Plasmodium vivax histone deacetylase 1, putative 0.0093 0.0438 0.3339
Entamoeba histolytica cysteine proteinase, putative 0.0125 0.0637 0.49
Brugia malayi cathepsin Z-like cysteine proteinase 0.0052 0.0185 0.0679
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Onchocerca volvulus 0.023 0.13 1
Schistosoma mansoni hypothetical protein 0.0047 0.0153 0.024
Schistosoma mansoni hypothetical protein 0.1033 0.6326 1
Plasmodium falciparum histone deacetylase 2 0.0076 0.0331 0.251
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0185 0.0291
Loa Loa (eye worm) hypothetical protein 0.0093 0.0438 0.1653
Echinococcus granulosus histone deacetylase 8 0.0048 0.0156 0.0238
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0098 0.0471 0.0744
Giardia lamblia Cysteine protease 0.0052 0.0185 0.1812
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0115 0.0579 0.1835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Loa Loa (eye worm) animal heme peroxidase 0.013 0.067 0.253
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0329 0.1204
Echinococcus multilocularis cysteine protease 0.023 0.13 0.1296
Mycobacterium ulcerans lipase LipD 0.0075 0.0329 1
Echinococcus multilocularis solute carrier family 5 0.0037 0.009 0.0085
Brugia malayi Animal haem peroxidase family protein 0.013 0.067 0.2515
Trypanosoma cruzi histone deacetylase, putative 0.0076 0.0331 0.121
Onchocerca volvulus 0.0098 0.0471 0.3597
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0989
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.1222 0.4615
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422
Toxoplasma gondii cathepsin CPC2 0.0052 0.0185 0.1313
Brugia malayi Animal haem peroxidase family protein 0.013 0.067 0.2515
Toxoplasma gondii histone deacetylase HDAC5 0.0048 0.0156 0.1089
Schistosoma mansoni hypothetical protein 0.0043 0.0129 0.0202
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0185 0.0291
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0112 0.0556 0.0872
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Brugia malayi cathepsin B-like cysteine proteinase 0.0446 0.2649 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0438 0.0692
Plasmodium vivax vivapain-2 0.023 0.13 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Trichomonas vaginalis esterase, putative 0.0075 0.0329 0.2161
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0052 0.0185 0.0679
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Plasmodium falciparum serine repeat antigen 8 0.0052 0.0185 0.1386
Leishmania major hypothetical protein, conserved 0.0075 0.0329 0.1931
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0794 0.2981
Echinococcus multilocularis histone deacetylase 6 0.0076 0.0331 0.0325
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0329 0.2161
Brugia malayi mbt repeat family protein 0.0098 0.0471 0.1762
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0329 0.0948
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0174 0.0947 0.3547
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0083 0.0078
Trypanosoma cruzi cysteine proteinase, putative 0.0125 0.0637 0.2373
Echinococcus multilocularis histone deacetylase 6 0.0082 0.0369 0.0363
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0072 0.0309 0.1146
Mycobacterium tuberculosis Conserved protein 0.0075 0.0329 0.0948
Brugia malayi Histone deacetylase family protein 0.0076 0.0331 0.123
Echinococcus granulosus snurportin 1 0.0326 0.1898 0.2994
Echinococcus granulosus importin subunit beta 1 0.0031 0.0048 0.0066
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.0177 0.4308
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.023 0.13 0.1296
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0016 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0329 0.0512
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0051 0.0175 0.0268
Trypanosoma cruzi histone deacetylase, putative 0.0076 0.0331 0.121
Brugia malayi Importin beta-1 subunit 0.0031 0.0048 0.0159
Echinococcus granulosus solute carrier family 5 0.0037 0.009 0.0134
Trypanosoma brucei cysteine peptidase C (CPC) 0.0174 0.0947 0.5674
Schistosoma mansoni high-affinity choline transporter 0.0339 0.1978 0.3126
Loa Loa (eye worm) blistered cuticle protein 3 0.013 0.067 0.253
Loa Loa (eye worm) hypothetical protein 0.0072 0.0309 0.1165
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0083 0.0123
Echinococcus granulosus cathepsin b 0.0446 0.2649 0.4182
Entamoeba histolytica cysteine protease, putative 0.023 0.13 1
Onchocerca volvulus 0.013 0.067 0.5133
Leishmania major cathepsin L-like protease 0.0287 0.1656 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0129 0.0195
Plasmodium vivax vivapain-3 0.0125 0.0637 0.4878
Onchocerca volvulus 0.023 0.13 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0749 0.0744
Brugia malayi GH02984p 0.0339 0.1978 0.7464
Echinococcus granulosus histone deacetylase 3 0.0093 0.0438 0.0684
Schistosoma mansoni transient receptor potential channel 0.0064 0.026 0.041
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0329 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0125 0.0637 0.4258
Toxoplasma gondii histone deacetylase HDAC2 0.0093 0.0438 0.3283
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0062 0.0193
Leishmania major pyruvate kinase 0.0033 0.0062 0.031
Schistosoma mansoni hypothetical protein 0.06 0.3618 0.5718
Plasmodium falciparum serine repeat antigen 4 0.0052 0.0185 0.1386
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Schistosoma mansoni sodium/solute symporter 0.0037 0.009 0.0141
Echinococcus granulosus cathepsin l1 0.023 0.13 0.2049
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Plasmodium falciparum histone deacetylase 1 0.0093 0.0438 0.3339
Schistosoma mansoni hypothetical protein 0.0047 0.0153 0.024
Entamoeba histolytica hypothetical protein 0.0052 0.0185 0.1422
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0185 0.1181
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.1383 0.5222
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0329 0.1224
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0052 0.0185 0.1386
Brugia malayi cathepsin L-like precursor 0.0158 0.0848 0.3188
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Trypanosoma cruzi cysteine peptidase, putative 0.0287 0.1656 0.6237
Giardia lamblia Cathepsin L-like protease 0.0052 0.0185 0.1812
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0447 0.0441
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Onchocerca volvulus Histone deacetylase 10 homolog 0.0048 0.0156 0.1163
Loa Loa (eye worm) hypothetical protein 0.0072 0.0309 0.1165
Toxoplasma gondii cathepsin CPL 0.023 0.13 1
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0329 0.2161
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0329 0.2161
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0989
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0052 0.0185 0.0698
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0048 0.019
Echinococcus multilocularis snurportin 1 0.0326 0.1898 0.1893
Leishmania major cathepsin L-like protease 0.023 0.13 0.7836
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0329 0.1204
Echinococcus multilocularis pyruvate kinase 0.0033 0.0062 0.0057
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Onchocerca volvulus 0.023 0.13 1
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0922 0.7081
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0438 0.0685
Brugia malayi Histone deacetylase family protein 0.0076 0.0331 0.123
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0052 0.0185 0.1422
Toxoplasma gondii histone deacetylase HDAC1 0.0076 0.0331 0.2447
Trypanosoma brucei histone deacetylase 2 0.0048 0.0156 0.0853
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0185 0.0679
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0166 0.0911
Loa Loa (eye worm) hypothetical protein 0.0033 0.0063 0.0238
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0021
Loa Loa (eye worm) histone deacetylase 11 0.0048 0.0156 0.059
Loa Loa (eye worm) animal heme peroxidase 0.013 0.067 0.253
Entamoeba histolytica cysteine proteinase, putative 0.023 0.13 1
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.0471 0.0744
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.024 0.0906
Onchocerca volvulus 0.0075 0.0329 0.2498
Plasmodium vivax histone deacetylase, putative 0.0048 0.0156 0.1163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0329 0.2498
Echinococcus granulosus pyruvate kinase 0.0033 0.0062 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0016 0.003
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.1383 0.5222
Giardia lamblia Cathepsin B precursor 0.0174 0.0947 1
Schistosoma mansoni histone deacetylase 1 2 3 0.0048 0.0156 0.0245
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0052 0.0185 0.0291
Loa Loa (eye worm) hypothetical protein 0.015 0.0794 0.2996
Leishmania major oligopeptidase b 0.0051 0.0177 0.1008
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0006 0.0021
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0185 0.0291
Echinococcus granulosus prolyl endopeptidase 0.0129 0.0663 0.1041
Schistosoma mansoni hypothetical protein 0.0024 0.0006 0.0007
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0166 0.1237
Loa Loa (eye worm) hypothetical protein 0.0339 0.1978 0.7469
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0052 0.0185 0.1386
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.1481 0.5592
Giardia lamblia Cathepsin B precursor 0.0052 0.0185 0.1812
Echinococcus granulosus cathepsin b 0.0446 0.2649 0.4182
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0052 0.0185 0.1386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Loa Loa (eye worm) histone deacetylase 0.0076 0.0331 0.1248
Trypanosoma cruzi cysteine peptidase, putative 0.0125 0.0637 0.2373
Schistosoma mansoni transient receptor potential channel 0.0097 0.0467 0.0737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Schistosoma mansoni myelin transcription factor 1 myt1 0.0112 0.0556 0.0878
Echinococcus multilocularis cathepsin L cysteine protease 0.023 0.13 0.1296
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0016 0.0125
Brugia malayi Cathepsin L-like precursor 0.0158 0.0848 0.3188
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Giardia lamblia Cathepsin L-like protease 0.0052 0.0185 0.1812
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0153 0.0233
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.098 0.6589
Echinococcus granulosus flap endonuclease 1 0.0026 0.0016 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0129 0.0202
Brugia malayi mbt repeat family protein 0.0098 0.0471 0.1762
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0446 0.2649 0.4186
Brugia malayi Animal haem peroxidase family protein 0.013 0.067 0.2515
Trypanosoma cruzi prolyl endopeptidase 0.0129 0.0663 0.2472
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0329 0.0324
Onchocerca volvulus Peroxidase homolog 0.013 0.067 0.5133
Entamoeba histolytica histone deacetylase, putative 0.0093 0.0438 0.3367
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0175 0.1113
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Plasmodium falciparum cysteine proteinase falcipain 2b 0.023 0.13 1
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.026 0.0403
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.026 0.0255
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0989
Plasmodium falciparum serine repeat antigen 6 0.0052 0.0185 0.1386
Giardia lamblia Cysteine protease 0.0052 0.0185 0.1812
Brugia malayi Animal haem peroxidase family protein 0.013 0.067 0.2515
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.023 0.13 0.877
Giardia lamblia Histone deacetylase 0.0093 0.0438 0.4529
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0446 0.2649 0.4186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Loa Loa (eye worm) hypothetical protein 0.0047 0.0153 0.0577
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Loa Loa (eye worm) cysteine protease 0.023 0.13 0.4909
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0185 0.0679
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1646 0.1641
Schistosoma mansoni hypothetical protein 0.0058 0.0221 0.0348
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0062 0.0281
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0062 0.0235
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0329 0.0519
Leishmania major cathepsin L-like protease 0.023 0.13 0.7836
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0052 0.0185 0.0291
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.018
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0166 0.1237
Schistosoma mansoni cathepsin F (C01 family) 0.023 0.13 0.2054
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Echinococcus multilocularis prolyl endopeptidase 0.0129 0.0663 0.0658
Trypanosoma cruzi histone deacetylase 1, putative 0.0093 0.0438 0.1617
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0153 0.0557
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0098 0.0471 0.3597
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0083 0.0295
Plasmodium vivax unspecified product 0.0125 0.0637 0.4878
Echinococcus multilocularis cathepsin b 0.0446 0.2649 0.2645
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0052 0.0185 0.1386
Schistosoma mansoni histone deacetylase 4 5 0.0076 0.0331 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.023 0.13 0.877
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.023 0.13 0.4909
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0052 0.0185 0.1386
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Schistosoma mansoni cathepsin F (C01 family) 0.023 0.13 0.2054
Schistosoma mansoni cathepsin F (C01 family) 0.0158 0.0848 0.1339
Echinococcus granulosus cathepsin L cysteine protease 0.0125 0.0637 0.0999
Onchocerca volvulus Cathepsin L homolog 0.023 0.13 1
Brugia malayi MH2 domain containing protein 0.0244 0.1383 0.5212
Loa Loa (eye worm) hypothetical protein 0.0286 0.1646 0.6213
Brugia malayi beta-lactamase family protein 0.0075 0.0329 0.1224
Plasmodium falciparum serine repeat antigen 1 0.0052 0.0185 0.1386
Onchocerca volvulus Dual oxidase homolog 0.013 0.067 0.5133
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Schistosoma mansoni hypothetical protein 0.0102 0.0497 0.0784
Loa Loa (eye worm) hypothetical protein 0.0446 0.2649 1
Brugia malayi Cathepsin L-like precursor 0.0072 0.0309 0.1146
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0052 0.0185 0.1386
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0329 0.0948
Echinococcus granulosus ubiquitin specific protease 41 0.0051 0.0175 0.0268
Echinococcus multilocularis cathepsin L cysteine protease 0.023 0.13 0.1296
Plasmodium vivax vivapain-2 0.023 0.13 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0051 0.0175 0.1346
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.059
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0166 0.0585
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.0185 0.1181
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.009 0.0085
Onchocerca volvulus 0.0148 0.0785 0.6017
Leishmania major cathepsin L-like protease 0.023 0.13 0.7836
Giardia lamblia Cathepsin B precursor 0.0174 0.0947 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0112 0.0556 0.2084
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422
Onchocerca volvulus 0.0075 0.0329 0.2498
Echinococcus multilocularis histone acetyltransferase MYST2 0.0112 0.0556 0.0551
Echinococcus granulosus histone deacetylase 6 0.0076 0.0331 0.0514
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0052 0.0185 0.0291
Loa Loa (eye worm) hypothetical protein 0.0158 0.0848 0.3202
Schistosoma mansoni transient receptor potential channel 0.0064 0.026 0.041
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0185 0.0698
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0174 0.0947 0.1496
Onchocerca volvulus 0.013 0.067 0.5133
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0166 0.1237
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0329 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.0185 0.1181
Echinococcus multilocularis histone deacetylase 3 0.0093 0.0438 0.0433
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.13 0.4887
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0329 1
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0052 0.0185 0.1386
Plasmodium falciparum serine repeat antigen 7 0.0052 0.0185 0.1386
Mycobacterium tuberculosis Conserved protein 0.0075 0.0329 0.0948
Echinococcus granulosus histone deacetylase 6 0.0082 0.0369 0.0575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Plasmodium falciparum cysteine proteinase falcipain 1 0.0125 0.0637 0.4878
Trypanosoma brucei prolyl endopeptidase 0.0129 0.0663 0.3945
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Mycobacterium ulcerans beta-lactamase 0.0075 0.0329 1
Plasmodium falciparum serine repeat antigen 3 0.0052 0.0185 0.1386
Schistosoma mansoni lipoxygenase 0.01 0.048 0.0758
Leishmania major cathepsin L-like protease 0.023 0.13 0.7836
Leishmania major histone deacetylase, putative 0.0076 0.0331 0.194
Brugia malayi hypothetical protein 0.013 0.067 0.2515
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0052 0.0185 0.1181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Brugia malayi hypothetical protein 0.0148 0.0785 0.2948
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0467 0.0462
Schistosoma mansoni cathepsin C 0.0052 0.0185 0.0291
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.009 0.0134
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Leishmania major cathepsin L-like protease 0.0287 0.1656 1
Giardia lamblia Hypothetical protein 0.0052 0.0185 0.1812
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0051 0.0175 0.0268
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.1481 0.5583
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Onchocerca volvulus Peroxidasin homolog 0.013 0.067 0.5133
Plasmodium vivax vivapain-1 0.0125 0.0637 0.4878
Loa Loa (eye worm) hypothetical protein 0.023 0.13 0.4909
Echinococcus multilocularis pyruvate kinase 0.0033 0.0062 0.0057
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0062 0.0281
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0016 0.0019
Echinococcus multilocularis histone deacetylase 0.0076 0.0331 0.0325
Trypanosoma cruzi histone deacetylase 1, putative 0.0093 0.0438 0.1617
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0185 0.0679
Loa Loa (eye worm) hypothetical protein 0.0158 0.0848 0.3202
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0062 0.0235
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0185 0.1386
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0051 0.0175 0.0641
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0329 0.0948
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Trypanosoma cruzi cruzipain precursor, putative 0.0287 0.1656 0.6237
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0116
Brugia malayi cathepsin L-like cysteine proteinase 0.0052 0.0185 0.0679
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0749 0.1176
Toxoplasma gondii cathepsin CPC1 0.0052 0.0185 0.1313
Trypanosoma cruzi major cysteine proteinase, putative 0.0109 0.0541 0.2008
Brugia malayi cathepsin Z-like cysteine proteinase 0.0052 0.0185 0.0679
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0062 0.009
Trypanosoma brucei oligopeptidase b 0.0051 0.0177 0.0981
Brugia malayi Papain family cysteine protease containing protein 0.023 0.13 0.4899
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0185 0.0698
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0062 0.0347
Brugia malayi Flap endonuclease-1 0.0026 0.0016 0.0041
Plasmodium vivax serine-repeat antigen (SERA) 0.0052 0.0185 0.1386
Brugia malayi cathepsin L precursor 0.0052 0.0185 0.0679
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0051 0.0175 0.1705
Brugia malayi hypothetical protein 0.0049 0.0166 0.0606
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0309 0.1127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Loa Loa (eye worm) beta-lactamase 0.0075 0.0329 0.1242
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0153 0.0557
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Loa Loa (eye worm) histone deacetylase 1 0.0093 0.0438 0.1653
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0438 0.0433
Giardia lamblia Hypothetical protein 0.0052 0.0185 0.1812
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0052 0.0185 0.1812
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.0177 0.1008
Toxoplasma gondii ABC1 family protein 0.0075 0.0329 0.2435
Leishmania major histone deacetylase, putative 0.0093 0.0438 0.2592
Entamoeba histolytica cysteine proteinase 1, putative 0.0125 0.0637 0.49
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0989
Brugia malayi Papain family cysteine protease containing protein 0.0125 0.0637 0.239
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1646 0.2595
Echinococcus granulosus SAM and MBT domain containing protein 0.0098 0.0471 0.0737
Onchocerca volvulus 0.0075 0.0329 0.2498
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.0185 0.1181
Onchocerca volvulus Cathepsin F homolog 0.023 0.13 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0153 0.0147
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0062 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Plasmodium falciparum importin beta, putative 0.0031 0.0048 0.0325
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0329 0.0948
Onchocerca volvulus Peroxidasin homolog 0.013 0.067 0.5133
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0016 0.0083
Schistosoma mansoni inositol transporter 0.0037 0.009 0.0141
Echinococcus multilocularis histone deacetylase 7 0.0076 0.0331 0.0325
Schistosoma mansoni survival motor neuron protein 0.0058 0.0221 0.0348
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0315
Entamoeba histolytica cysteine proteinase, putative 0.0125 0.0637 0.49
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Loa Loa (eye worm) hypothetical protein 0.0097 0.0467 0.1763
Schistosoma mansoni cathepsin S (C01 family) 0.0052 0.0185 0.0291
Echinococcus granulosus histone deacetylase 6 0.0076 0.0331 0.0514
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0329 0.0948
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0052 0.0185 0.0291
Schistosoma mansoni lipoxygenase 0.0142 0.0749 0.1182
Mycobacterium leprae Probable lipase LipE 0.0075 0.0329 1
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0174 0.0947 0.5687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0158 0.0848 0.5693
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0438 0.0685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0158 0.0848 0.5693
Giardia lamblia Cathepsin B precursor 0.0052 0.0185 0.1812
Schistosoma mansoni loxhd1 0.0024 0.0006 0.0007
Brugia malayi hypothetical protein 0.0032 0.0056 0.0191
Brugia malayi N-terminal motif family protein 0.0218 0.1222 0.4604
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0129 0.0663 0.3963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Schistosoma mansoni importin beta-1 0.0031 0.0048 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0052 0.0185 0.1181
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Brugia malayi histone deacetylase 1 (HD1) 0.0093 0.0438 0.1636
Echinococcus granulosus high affinity choline transporter 1 0.0339 0.1978 0.3121
Schistosoma mansoni histone deacetylase 0.0093 0.0438 0.0691
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Schistosoma mansoni cathepsin s 0.0072 0.0309 0.0486
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0446 0.2649 1
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Echinococcus granulosus cathepsin L cysteine proteinase 0.023 0.13 0.2049
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Echinococcus multilocularis histone deacetylase 8 0.0048 0.0156 0.0151
Entamoeba histolytica hypothetical protein 0.0025 0.0011 0.0088
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.0177 0.0981
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Onchocerca volvulus 0.023 0.13 1
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0329 0.1907
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0051 0.0175 0.0275
Echinococcus multilocularis histone deacetylase 6 0.0076 0.0331 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Trypanosoma brucei histone deacetylase, putative 0.0076 0.0331 0.1916
Brugia malayi histone deacetylase 3 (HD3) 0.0093 0.0438 0.1636
Loa Loa (eye worm) hypothetical protein 0.0033 0.0062 0.0235
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Plasmodium vivax importin-beta 2, putative 0.0031 0.0048 0.0325
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0215 0.1204 0.4523
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Echinococcus granulosus histone deacetylase 7 0.0076 0.0331 0.0514
Toxoplasma gondii prolyl endopeptidase 0.0129 0.0663 0.5038
Brugia malayi histone deacetylase 11 0.0048 0.0156 0.057
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0174 0.0947 0.6365
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0112 0.0556 0.0551
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Giardia lamblia Cysteine protease 0.0052 0.0185 0.1812
Trypanosoma cruzi histone deacetylase, putative 0.0048 0.0156 0.0549
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.026 0.0403
Schistosoma mansoni histone deacetylase hda2 0.0048 0.0156 0.0245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0438 0.0692
Onchocerca volvulus 0.0037 0.009 0.0655
Schistosoma mansoni hypothetical protein 0.0326 0.1898 0.2999
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0098 0.0471 0.0466
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Plasmodium falciparum cysteine proteinase falcipain 3 0.023 0.13 1
Brugia malayi hypothetical protein 0.0043 0.0129 0.0466
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0072 0.0309 0.1165
Echinococcus multilocularis geminin 0.1033 0.6326 0.6324
Mycobacterium ulcerans hypothetical protein 0.0075 0.0329 1
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0016 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Onchocerca volvulus 0.023 0.13 1
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.009 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Echinococcus multilocularis cathepsin L 0.0125 0.0637 0.0632
Schistosoma mansoni histone deacetylase 0.0093 0.0438 0.0691
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0185 0.0658
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Echinococcus granulosus cathepsin L 0.0052 0.0185 0.0284
Leishmania major cathepsin L-like protease 0.0287 0.1656 1
Loa Loa (eye worm) animal heme peroxidase 0.013 0.067 0.253
Plasmodium falciparum serine repeat antigen 2 0.0052 0.0185 0.1386
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0016 0.0011
Trypanosoma cruzi oligopeptidase b 0.0051 0.0177 0.0629
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0051 0.0175 0.0995
Brugia malayi RNA, U transporter 1 0.0087 0.04 0.1493
Brugia malayi Cathepsin L-like cysteine proteinase 0.0158 0.0848 0.3188
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0062 0.0439
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.0185 0.0679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Loa Loa (eye worm) hypothetical protein 0.0037 0.009 0.0341
Loa Loa (eye worm) hypothetical protein 0.0098 0.0471 0.1779
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.026 0.0255
Plasmodium falciparum serine repeat antigen 9 0.0052 0.0185 0.1386
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0093 0.0438 0.2901
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0051 0.0175 0.017
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0125 0.0637 0.1006
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.0177 0.0981
Loa Loa (eye worm) hypothetical protein 0.0112 0.0556 0.2101
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0175 0.0968
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.0177 0.4308
Leishmania major histone deacetylase, putative 0.0076 0.0331 0.194
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0175 0.062
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0447 0.0698
Toxoplasma gondii preprocathepsin c precursor, putative 0.0052 0.0185 0.1313
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0052 0.0185 0.1181
Plasmodium falciparum pyruvate kinase 0.0033 0.0062 0.0439
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0052 0.0185 0.1422
Echinococcus multilocularis cathepsin L 0.0052 0.0185 0.018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0329 0.1242
Loa Loa (eye worm) hypothetical protein 0.0072 0.0309 0.1165
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0467 0.0737
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Echinococcus multilocularis GPCR, family 2 0.0047 0.0153 0.0147
Onchocerca volvulus 0.0058 0.0221 0.1666
Giardia lamblia Cysteine protease 0.0052 0.0185 0.1812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Schistosoma mansoni histone deacetylase 4 5 0.0076 0.0331 0.0521
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0052 0.0185 0.1386
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.0177 0.0408
Onchocerca volvulus 0.013 0.067 0.5133
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0051 0.0175 0.1113
Echinococcus granulosus peroxidasin 0.013 0.067 0.1052
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0153 0.0233
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0051 0.0175 0.0275
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.009 0.0134
Toxoplasma gondii histone deacetylase HDAC3 0.0093 0.0438 0.3283
Echinococcus granulosus endonuclease exonuclease phosphatase 0.039 0.2303 0.3635
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Echinococcus granulosus cathepsin l1 0.0158 0.0848 0.1333
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0062 0.0193
Loa Loa (eye worm) hypothetical protein 0.0129 0.0663 0.2504
Schistosoma mansoni polycystin 1-related 0.0024 0.0006 0.0007
Leishmania major pyruvate kinase 0.0033 0.0062 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0185 0.1181
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.026
Leishmania major histone deacetylase, putative 0.0093 0.0438 0.2592
Chlamydia trachomatis pyruvate kinase 0.0033 0.0062 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0438 0.1655
Echinococcus granulosus cathepsin L 0.0125 0.0637 0.0999
Mycobacterium tuberculosis Probable peptidase 0.0051 0.0177 0.0408
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.0185 0.1181
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0052 0.0185 0.1812
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.0663 0.1047
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0446 0.2649 0.4186
Loa Loa (eye worm) hypothetical protein 0.0049 0.0166 0.0626
Echinococcus multilocularis polycomb protein SCMH1 0.0098 0.0471 0.0466
Leishmania major cysteine peptidase A (CPA) 0.023 0.13 0.7836
Echinococcus granulosus GPCR family 2 0.0047 0.0153 0.0233
Brugia malayi Histone deacetylase 1 0.0093 0.0438 0.1636
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.098 0.6589
Plasmodium vivax histone deacetylase, putative 0.0076 0.0331 0.251
Loa Loa (eye worm) papain family cysteine protease containing protein 0.023 0.13 0.4909
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.009 0.0134
Leishmania major hypothetical protein, conserved 0.0049 0.0166 0.0938
Loa Loa (eye worm) histone deacetylase 3 0.0093 0.0438 0.1653
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0125 0.0637 0.1006
Loa Loa (eye worm) hypothetical protein 0.0148 0.0785 0.2962
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0048 0.0243
Onchocerca volvulus Prolyl endopeptidase homolog 0.0129 0.0663 0.508
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0438 0.1638
Entamoeba histolytica cysteine proteinase, putative 0.0158 0.0848 0.6523
Brugia malayi Peroxidasin 0.013 0.067 0.2515
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0021
Schistosoma mansoni hypothetical protein 0.0047 0.0153 0.024
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0051 0.0175 0.1113
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0446 0.2649 0.4186
Giardia lamblia Cathepsin B precursor 0.0052 0.0185 0.1812
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0329 0.0948
Echinococcus multilocularis ubiquitin specific protease 41 0.0051 0.0175 0.017
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0438 0.0433
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0467 0.073
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0329 0.0519
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0048 0.019
Echinococcus granulosus cysteine protease 0.0125 0.0637 0.0999
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0062 0.0439
Trypanosoma brucei histone deacetylase 3 0.0076 0.0331 0.1916
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0221 0.0816
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0048 0.0042
Brugia malayi hypothetical protein 0.0286 0.1646 0.6205
Entamoeba histolytica cysteine proteinase, putative 0.0125 0.0637 0.49
Plasmodium vivax histone deacetylase 2, putative 0.0076 0.0331 0.251
Trypanosoma cruzi cysteine protease, putative 0.0125 0.0637 0.2373
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0166 0.0585
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0051 0.0175 0.017
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0482 0.2876 1
Trypanosoma brucei histone deacetylase 4 0.0076 0.0331 0.1916
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0497 0.1859
Loa Loa (eye worm) fibroinase 0.023 0.13 0.4909
Brugia malayi beta-lactamase family protein 0.0075 0.0329 0.1224
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0166 0.1164
Echinococcus granulosus histone deacetylase 1 0.0093 0.0438 0.0684
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0153 0.0577
Schistosoma mansoni hypothetical protein 0.0047 0.0153 0.024
Loa Loa (eye worm) cathepsin B 0.0174 0.0947 0.3575
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Schistosoma mansoni rab6-interacting 0.0024 0.0006 0.0007
Mycobacterium tuberculosis Conserved protein 0.0075 0.0329 0.0948
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0052 0.0185 0.1181
Trypanosoma cruzi histone deacetylase, putative 0.0048 0.0156 0.0549
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0093 0.0438 0.2901
Giardia lamblia Encystation-specific protease 0.0052 0.0185 0.1812
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0309 0.1127
Onchocerca volvulus 0.0158 0.0848 0.6508
Echinococcus multilocularis high affinity choline transporter 1 0.0339 0.1978 0.1974
Giardia lamblia Cathepsin B precursor 0.0052 0.0185 0.1812
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0185 0.1181
Loa Loa (eye worm) MBCTL1 0.0112 0.0556 0.2101
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0794 0.2981
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0637 0.3785
Onchocerca volvulus 0.023 0.13 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0112 0.0556 0.0872
Loa Loa (eye worm) histone deacetylase 7A 0.0076 0.0331 0.1248
Brugia malayi cathepsin F-like cysteine proteinase 0.0072 0.0309 0.1146
Onchocerca volvulus Peroxidase homolog 0.013 0.067 0.5133
Loa Loa (eye worm) mbt repeat family protein 0.0098 0.0471 0.1779
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0052 0.0185 0.1386
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.0663 0.1047
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0794 0.2996
Trypanosoma cruzi histone deacetylase, putative 0.0076 0.0331 0.121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0052 0.0185 0.1812
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Plasmodium vivax unspecified product 0.0052 0.0185 0.1386
Brugia malayi fibroinase precursor 0.0052 0.0185 0.0679
Schistosoma mansoni pyruvate kinase 0.0033 0.0062 0.0097
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0062 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Loa Loa (eye worm) hypothetical protein 0.0102 0.0497 0.1876
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Brugia malayi prolyl oligopeptidase family protein 0.0129 0.0663 0.2488
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422
Onchocerca volvulus 0.0052 0.0185 0.1386
Schistosoma mansoni rab6-interacting 0.0024 0.0006 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0287 0.1656 0.6237
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0052 0.0185 0.1386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0125 0.0637 0.4258
Onchocerca volvulus Chorion peroxidase homolog 0.013 0.067 0.5133
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.0177 0.0629
Echinococcus granulosus geminin 0.1033 0.6326 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0052 0.0185 0.1386
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0093 0.0438 0.2901
Schistosoma mansoni hypothetical protein 0.1033 0.6326 1
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.0471 0.0744
Trypanosoma cruzi oligopeptidase b 0.0051 0.0177 0.0629
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0125 0.0637 0.1006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0153 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0185 0.1181
Loa Loa (eye worm) hypothetical protein 0.0158 0.0848 0.3202
Brugia malayi beta-lactamase 0.0075 0.0329 0.1224
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.009 0.0577
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0062 0.0439
Schistosoma mansoni inositol transporter 0.0037 0.009 0.0141
Schistosoma mansoni cathepsin B (C01 family) 0.0052 0.0185 0.0291
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0329 0.2161
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0125 0.0637 0.2373
Giardia lamblia Cathepsin B precursor 0.0174 0.0947 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0438 0.0692
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.1222 0.9397
Echinococcus multilocularis pyruvate kinase 0.0026 0.0019 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0637 0.3785
Toxoplasma gondii cathepsin B 0.0174 0.0947 0.7248
Loa Loa (eye worm) hypothetical protein 0.0051 0.0175 0.0661
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.039 0.2303 0.2299
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0129 0.0123
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0062 0.0235
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.0177 0.0629
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0062 0.0439
Brugia malayi Sodium:solute symporter family protein 0.0037 0.009 0.0321
Echinococcus granulosus cathepsin l cysteine peptidase 0.023 0.13 0.2049
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0052 0.0185 0.1386
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.1898 0.7165
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0052 0.0185 0.1386
Trypanosoma brucei histone deacetylase 1 0.0093 0.0438 0.257
Schistosoma mansoni peroxidasin 0.013 0.067 0.1058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0329 0.0948
Leishmania major cathepsin L-like protease 0.023 0.13 0.7836
Plasmodium falciparum serine repeat antigen 5 0.0052 0.0185 0.1386
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0185 0.1181
Giardia lamblia Cathepsin B precursor 0.0052 0.0185 0.1812
Brugia malayi Animal haem peroxidase family protein 0.013 0.067 0.2515
Schistosoma mansoni histone deacetylase hda2 0.0082 0.0369 0.0581
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Brugia malayi Papain family cysteine protease containing protein 0.0125 0.0637 0.239
Echinococcus multilocularis histone deacetylase 1 0.0093 0.0438 0.0433
Echinococcus granulosus polycomb protein SCMH1 0.0098 0.0471 0.0737
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0185 0.0291
Echinococcus multilocularis cathepsin l cysteine peptidase 0.023 0.13 0.1296
Schistosoma mansoni peroxidasin 0.013 0.067 0.1058
Trypanosoma cruzi cysteine proteinase, putative 0.0125 0.0637 0.2373
Trypanosoma cruzi cysteine peptidase, putative 0.0287 0.1656 0.6237
Giardia lamblia Pyruvate kinase 0.0033 0.0062 0.0494
Echinococcus multilocularis cysteine protease 0.023 0.13 0.1296
Onchocerca volvulus Cathepsin L homolog 0.023 0.13 1
Plasmodium falciparum flap endonuclease 1 0.0026 0.0016 0.0083
Onchocerca volvulus 0.023 0.13 1
Loa Loa (eye worm) ctsf protein 0.023 0.13 0.4909
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0062 0.0215
Toxoplasma gondii histone deacetylase HDAC4 0.0048 0.0156 0.1089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Brugia malayi Cathepsin L-like precursor 0.0158 0.0848 0.3188
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.009 0.0085
Brugia malayi Blistered cuticle protein 3 0.013 0.067 0.2515
Loa Loa (eye worm) animal heme peroxidase 0.013 0.067 0.253
Entamoeba histolytica cysteine proteinase 2 0.0125 0.0637 0.49
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0052 0.0185 0.1812
Entamoeba histolytica cysteine proteinase, putative 0.0125 0.0637 0.49
Plasmodium falciparum histone deacetylase, putative 0.0076 0.0331 0.251
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0062 0.0358
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.009 0.0085
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0329 0.2161
Echinococcus multilocularis peroxidasin 0.013 0.067 0.0665
Schistosoma mansoni pyruvate kinase 0.0033 0.0062 0.0097
Entamoeba histolytica cysteine proteinase, putative 0.023 0.13 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Echinococcus multilocularis cathepsin b 0.0446 0.2649 0.2645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Plasmodium vivax unspecified product 0.0072 0.0309 0.234
Plasmodium falciparum cysteine proteinase falcipain 2a 0.023 0.13 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0052 0.0185 0.1386
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0175 0.062

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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