Detailed information for compound 1309273

Basic information

Technical information
  • TDR Targets ID: 1309273
  • Name: 1-(1-cyclohexylbenzimidazol-2-yl)ethanol
  • MW: 244.332 | Formula: C15H20N2O
  • H donors: 1 H acceptors: 2 LogP: 2.7 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1nc2c(n1C1CCCCC1)cccc2)O
  • InChi: 1S/C15H20N2O/c1-11(18)15-16-13-9-5-6-10-14(13)17(15)12-7-3-2-4-8-12/h5-6,9-12,18H,2-4,7-8H2,1H3
  • InChiKey: RYTWUTIPDVPQJU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(1-cyclohexyl-2-benzimidazolyl)ethanol
  • MLS000048606
  • SMR000060629
  • Oprea1_060687
  • STOCK1S-88150
  • Enamine_001315
  • Oprea1_756736

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0237 0.0715
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0093 0.0093
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0093 0.0093
Echinococcus granulosus dynamin 1 0.0023 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0094 0.0495 0.075
Schistosoma mansoni opsin-like receptor 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0061 0.0289 0.0438
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0938 0.6371
Echinococcus granulosus g protein coupled receptor 0.0052 0.0237 0.0237
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 0.0237 0.0237
Echinococcus multilocularis G protein coupled receptor 139 0.0052 0.0237 0.0237
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0093 0.0282
Toxoplasma gondii transporter, cation channel family protein 0.0111 0.0594 1
Onchocerca volvulus 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0049 0.0216 0.0327
Loa Loa (eye worm) hypothetical protein 0.0061 0.0289 0.0438
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0093 0.0093
Toxoplasma gondii hypothetical protein 0.0097 0.0513 0.8628
Loa Loa (eye worm) hypothetical protein 0.0061 0.0289 0.0438
Echinococcus granulosus sodium and chloride dependent glycine 0.0094 0.0495 0.0495
Echinococcus granulosus g protein coupled receptor 0.0052 0.0237 0.0237
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0061 0.0289 0.0289
Schistosoma mansoni amine GPCR 0.0052 0.0237 0.0715
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0094 0.0495 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Loa Loa (eye worm) cytochrome P450 0.0014 0.0003 0.0005
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.1473 0.2231
Onchocerca volvulus 0.0094 0.0495 0.1493
Brugia malayi hypothetical protein 0.0094 0.0495 0.075
Schistosoma mansoni amine GPCR 0.0052 0.0237 0.0715
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 0.0237 0.0359
Schistosoma mansoni hypothetical protein 0.0052 0.0237 0.0715
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 0.0237 0.0359
Brugia malayi follicle stimulating hormone receptor 0.0052 0.0237 0.0359
Brugia malayi Dynamin central region family protein 0.0021 0.0047 0.0071
Trypanosoma cruzi dynamin-1-like protein 0.0021 0.0047 0.0071
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0173
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0093 0.0142
Brugia malayi nuclear receptor NHR-88 0.0061 0.0289 0.0438
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 0.0237 0.0715
Schistosoma mansoni hypothetical protein 0.0052 0.0237 0.0715
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0141 0.0141
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 0.0237 0.0359
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0093 0.0142
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0237 0.0237
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0201 0.0201
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0094 0.0495 0.1493
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0061 0.0289 0.0873
Schistosoma mansoni neuropeptide receptor 0.0052 0.0237 0.0715
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0289 0.0873
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0091 0.0138
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0055 0.0084
Schistosoma mansoni amine GPCR 0.0374 0.22 0.6635
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0289 0.0289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0141 0.6862
Schistosoma mansoni myosin xvIII 0.0052 0.0237 0.0715
Schistosoma mansoni hypothetical protein 0.0167 0.0938 0.2829
Entamoeba histolytica hypothetical protein 0.0043 0.0184 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0093 0.0142
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0061 0.0289 0.0873
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0237 0.0715
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0318 0.1859 0.1859
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0093 0.0142
Loa Loa (eye worm) hypothetical protein 0.0094 0.0495 0.075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0289 0.0438
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0093 0.0282
Schistosoma mansoni opsin-like receptor 0.0052 0.0237 0.0715
Echinococcus granulosus allatostatin A receptor 0.0052 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0094 0.0495 0.075
Loa Loa (eye worm) hypothetical protein 0.0557 0.3316 0.5023
Loa Loa (eye worm) hypothetical protein 0.0094 0.0495 0.075
Brugia malayi neuropeptide F receptor 0.0052 0.0237 0.0359
Onchocerca volvulus 0.0049 0.0216 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0289 0.0438
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0114 0.0173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0093 0.0093
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0237 0.0237
Echinococcus granulosus voltage dependent calcium channel 0.0111 0.0594 0.0594
Toxoplasma gondii hypothetical protein 0.0094 0.0495 0.8331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0061 0.0289 0.0438
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0289 0.0438
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Echinococcus granulosus neuropeptide receptor A26 0.0052 0.0237 0.0237
Echinococcus granulosus hypothetical protein 0.0052 0.0237 0.0237
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0055 0.3801
Brugia malayi Dynamin 0.0023 0.0057 0.0086
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0184 0.0554
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Schistosoma mansoni biogenic amine receptor 0.0052 0.0237 0.0715
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0094 0.0495 0.0495
Brugia malayi GnHR receptor homolog 0.0052 0.0237 0.0359
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1342 0.1342
Echinococcus multilocularis cpg binding protein 0.003 0.0101 0.0101
Trichomonas vaginalis dynamin, putative 0.0021 0.0047 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0938 0.6371
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0094 0.0495 0.1493
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Onchocerca volvulus 0.0052 0.0237 0.0715
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0094 0.0495 0.8331
Onchocerca volvulus 0.0052 0.0237 0.0715
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0237 0.0237
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 0.0237 0.0715
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 0.0237 0.0237
Echinococcus granulosus cpg binding protein 0.003 0.0101 0.0101
Leishmania major cytochrome p450-like protein 0.0014 0.0003 0.0005
Onchocerca volvulus 0.0029 0.0093 0.0282
Schistosoma mansoni sodium/chloride dependent transporter 0.0557 0.3316 1
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0047 0.0071
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0237 0.0237
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Brugia malayi hypothetical protein 0.0029 0.0093 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0061 0.0289 0.0438
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Loa Loa (eye worm) DR-78 0.0029 0.0093 0.0142
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 0.0237 0.0237
Echinococcus multilocularis neuropeptide receptor A26 0.0052 0.0237 0.0237
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.1473 0.2231
Leishmania major cytochrome p450-like protein 0.0022 0.0055 0.0084
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0184 0.0184
Brugia malayi sulfakinin receptor protein 0.0052 0.0237 0.0359
Brugia malayi Cytochrome P450 family protein 0.0051 0.0231 0.035
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Echinococcus multilocularis g-protein coupled receptor 0.0052 0.0237 0.0237
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0237 0.0237
Trypanosoma brucei C-8 sterol isomerase, putative 0.1095 0.6602 1
Echinococcus granulosus fmrfamide receptor 0.0052 0.0237 0.0237
Brugia malayi photoreceptor-specific nuclear receptor 0.0061 0.0289 0.0438
Leishmania major cytochrome p450-like protein 0.0014 0.0003 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0237 0.0359
Echinococcus multilocularis 0.0014 0.0003 0.0003
Echinococcus granulosus neuropeptide receptor 0.0052 0.0237 0.0237
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0055 0.0084
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0111 0.0594 0.09
Schistosoma mansoni sodium-dependent amino acid transporter 0.0094 0.0495 0.1493
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 0.0237 0.0359
Schistosoma mansoni nuclear hormone receptor 0.0061 0.0289 0.0873
Echinococcus granulosus serotonin transporter 0.0557 0.3316 0.3316
Schistosoma mansoni neuropeptide receptor 0.0052 0.0237 0.0715
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 0.0237 0.0715
Echinococcus multilocularis voltage dependent calcium channel 0.0318 0.1859 0.1859
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 0.0237 0.0715
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0094 0.0495 0.8331
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0094 0.0495 0.0495
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0318 0.1859 0.1859
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0061 0.0289 0.0289
Brugia malayi Inositol-1 0.0036 0.0141 0.0213
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0061 0.0289 0.0438
Loa Loa (eye worm) hypothetical protein 0.0061 0.0289 0.0438
Plasmodium falciparum transporter, putative 0.0094 0.0495 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 0.0237 0.0237
Leishmania major GTP-binding protein, putative 0.0021 0.0047 0.0071
Schistosoma mansoni steroid hormone receptor ad4bp 0.0061 0.0289 0.0873
Schistosoma mansoni hypothetical protein 0.0014 0.0003 0.0009
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0117 1
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1473 1
Echinococcus multilocularis FTZ F1 alpha 0.0061 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Onchocerca volvulus 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0318 0.1859 0.1859
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1473 1
Schistosoma mansoni cpg binding protein 0.003 0.0101 0.0305
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Brugia malayi putative neuropeptide receptor NPR1 0.0052 0.0237 0.0359
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0061 0.0289 0.0873
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0094 0.0495 0.1493
Loa Loa (eye worm) voltage-dependent calcium channel 0.0111 0.0594 0.09
Echinococcus granulosus serotonin receptor 0.0052 0.0237 0.0237
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0061 0.0289 0.0289
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1651 1 1
Schistosoma mansoni biogenic amine receptor 0.0052 0.0237 0.0715
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1095 0.6602 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 0.0237 0.0715
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0141 0.5
Echinococcus granulosus neuropeptide s receptor 0.0052 0.0237 0.0237
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0289 0.0438
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0237 0.0237
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1473 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0237 0.0715
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0061 0.0289 0.0438
Brugia malayi AKH receptor 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.1095 0.6602 1
Brugia malayi nuclear hormone receptor 0.0029 0.0093 0.0142
Trichomonas vaginalis dynamin, putative 0.0021 0.0047 0.0318
Loa Loa (eye worm) inositol-1 0.0036 0.0141 0.0213
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0557 0.3316 0.5023
Loa Loa (eye worm) hypothetical protein 0.0097 0.0513 0.0777
Schistosoma mansoni voltage-gated cation channel 0.0318 0.1859 0.5606
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 0.0237 0.0237
Schistosoma mansoni opsin-like receptor 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Echinococcus multilocularis sodium and chloride dependent glycine 0.0094 0.0495 0.0495
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 0.0237 0.0359
Loa Loa (eye worm) steroid hormone receptor 0.0061 0.0289 0.0438
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 0.0237 0.0359
Brugia malayi hypothetical protein 0.0052 0.0237 0.0359
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0318 0.1859 0.1859
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0237 0.0237
Echinococcus multilocularis dynamin 1 protein 0.0021 0.0047 0.0047
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0094 0.0495 0.075
Loa Loa (eye worm) hypothetical protein 0.0557 0.3316 0.5023
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0093 0.0093
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0318 0.1859 0.2816
Echinococcus multilocularis dynamin 1 0.0023 0.0057 0.0057
Brugia malayi hypothetical protein 0.0052 0.0237 0.0359
Schistosoma mansoni sodium/chloride dependent transporter 0.0094 0.0495 0.1493
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Brugia malayi hypothetical protein 0.0032 0.0114 0.0173
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0052 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Echinococcus multilocularis serotonin transporter 0.0557 0.3316 0.3316
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0061 0.0289 0.0873
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 0.0237 0.0359
Plasmodium vivax hypothetical protein, conserved 0.0094 0.0495 1
Brugia malayi nuclear receptor NHR-88 0.0029 0.0093 0.0142
Schistosoma mansoni neuropeptide receptor 0.0052 0.0237 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0061 0.0289 0.0438
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0201 0.0304
Brugia malayi hypothetical protein 0.0052 0.0237 0.0359
Brugia malayi cytochrome P450 0.0014 0.0003 0.0005
Schistosoma mansoni biogenic amine receptor 0.0052 0.0237 0.0715
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 0.0237 0.0237
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0117 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 0.0237 0.0715
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0237 0.0715
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0114 0.0345
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0055 0.0084
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 0.0237 0.0359
Onchocerca volvulus 0.0029 0.0093 0.0282
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0003 0.0005
Schistosoma mansoni cpg binding protein 0.003 0.0101 0.0305
Schistosoma mansoni nuclear receptor 0.0029 0.0093 0.0282
Schistosoma mansoni survival motor neuron protein 0.0048 0.0209 0.0629
Entamoeba histolytica hypothetical protein 0.0043 0.0184 1
Echinococcus granulosus geminin 0.0167 0.0938 0.0938
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 0.0237 0.0237
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0093 0.0093
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0237 0.0237
Brugia malayi hypothetical protein 0.0052 0.0237 0.0359
Echinococcus granulosus g protein coupled receptor 0.0052 0.0237 0.0237
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0938 0.6371
Onchocerca volvulus 0.0052 0.0237 0.0715
Schistosoma mansoni histamine h1 receptor 0.0052 0.0237 0.0715
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0993 0.6744
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0231 0.035
Brugia malayi Steroid receptor seven-up type 2 0.0061 0.0289 0.0438
Brugia malayi hypothetical protein 0.0052 0.0237 0.0359
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0094 0.0495 0.075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0173
Echinococcus multilocularis sodium and chloride dependent glycine 0.0094 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0061 0.0289 0.0438
Brugia malayi Cytochrome P450 family protein 0.0022 0.0055 0.0084
Onchocerca volvulus 0.0557 0.3316 1
Brugia malayi conserved hypotetical protein 0.0029 0.0093 0.0142
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0094 0.0495 0.1493
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0237 0.0237
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0289 0.0873
Onchocerca volvulus Protein ultraspiracle homolog 0.0061 0.0289 0.0873
Schistosoma mansoni hypothetical protein 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Brugia malayi ecdysone receptor 0.0029 0.0093 0.0142
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1473 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 0.0237 0.0237
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.0094 0.0495 0.075
Brugia malayi neuropeptide F receptor 0.0052 0.0237 0.0359
Echinococcus granulosus neuropeptide receptor 0.0052 0.0237 0.0237
Entamoeba histolytica hypothetical protein 0.0043 0.0184 1
Schistosoma mansoni cytochrome P450 0.0014 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0173
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0093 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0201 0.0605
Echinococcus granulosus orexin receptor type 2 0.0052 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0093 0.0282
Onchocerca volvulus 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0173
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0237 0.0715
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 0.0237 0.0237
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0061 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0173
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0086
Echinococcus granulosus g-protein coupled receptor 0.0052 0.0237 0.0237
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0237 0.0359
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0237 0.0237
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0237 0.0237
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0061 0.0289 0.0873
Echinococcus multilocularis voltage dependent calcium channel 0.0318 0.1859 0.1859
Brugia malayi RE15519p 0.0052 0.0237 0.0359
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0055 0.0084
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Onchocerca volvulus 0.0052 0.0237 0.0715
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Echinococcus granulosus sodium and chloride dependent glycine 0.0094 0.0495 0.0495
Echinococcus multilocularis orexin receptor type 2 0.0052 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0233 0.1342 0.2032
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0237 0.0715
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0093 0.0093
Entamoeba histolytica hypothetical protein 0.0043 0.0184 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0201 0.0201
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0061 0.0289 0.0289
Schistosoma mansoni hypothetical protein 0.0403 0.238 0.7177
Echinococcus multilocularis ecdysone induced protein 78C 0.0061 0.0289 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1473 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0094 0.0495 0.075
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0237 0.0237
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 0.0237 0.0237
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0114 0.0173
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0093 0.0282
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Toxoplasma gondii dynamin-related protein DRPB 0.0021 0.0047 0.0787
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 0.0237 0.0237
Brugia malayi nuclear receptor NHR-67 0.0029 0.0093 0.0142
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0237 0.0715
Brugia malayi tailless protein 0.0029 0.0093 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Schistosoma mansoni dynamin 0.0021 0.0047 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0938 0.6371
Brugia malayi CXXC zinc finger family protein 0.0028 0.0091 0.0138
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0055 0.0084
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0094 0.0495 0.1493
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Schistosoma mansoni hypothetical protein 0.0048 0.0209 0.0629
Loa Loa (eye worm) hypothetical protein 0.0061 0.0289 0.0438
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0093 0.0282
Loa Loa (eye worm) serotonin transporter b 0.0557 0.3316 0.5023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Brugia malayi ecdysteroid receptor 0.0061 0.0289 0.0438
Echinococcus granulosus tumor protein p63 0.0333 0.1952 0.1952
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0047 0.0071
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 0.0237 0.0237
Echinococcus granulosus FTZ F1 alpha 0.0061 0.0289 0.0289
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0094 0.0495 0.0495
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0003 0.0005
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.238 0.238
Schistosoma mansoni adenoreceptor 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Schistosoma mansoni zinc finger protein 0.0029 0.0093 0.0282
Onchocerca volvulus 0.0028 0.0091 0.0275
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0237 0.0359
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0237 0.0715
Schistosoma mansoni dynamin 0.0023 0.0057 0.0171
Echinococcus granulosus ecdysone induced protein 78C 0.0061 0.0289 0.0289
Trichomonas vaginalis dynamin, putative 0.0021 0.0047 0.0318
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0093 0.0093
Brugia malayi G-protein coupled receptor 0.0052 0.0237 0.0359
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0201 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0061 0.0289 0.0438
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 0.0237 0.0237
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0318 0.1859 0.1859
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Brugia malayi Melatonin receptor type 1A 0.0052 0.0237 0.0359
Trichomonas vaginalis mgm1, putative 0.0021 0.0047 0.0318
Schistosoma mansoni coup transcription factor 0.0061 0.0289 0.0873
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 0.0237 0.0237
Schistosoma mansoni inositol monophosphatase 0.0036 0.0141 0.0424
Schistosoma mansoni inositol monophosphatase 0.0036 0.0141 0.0424
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0938 0.6371
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0557 0.3316 1
Schistosoma mansoni dynamin 0.0023 0.0057 0.0171
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0061 0.0289 0.0289
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0055 0.0084
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1095 0.6602 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0003 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0246 0.4136
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0093 0.0093
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0237 0.0237
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0237 0.0237
Brugia malayi Dopamine receptor protein 1 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.0061 0.0289 0.0438
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0093 0.0142
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0093 0.0093
Onchocerca volvulus 0.0052 0.0237 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0289 0.0438
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0237 0.0237
Toxoplasma gondii dynamin-related protein DRPA 0.0021 0.0047 0.0787
Brugia malayi Serotonin receptor 0.0052 0.0237 0.0359
Treponema pallidum sodium- and chloride- dependent transporter 0.0557 0.3316 0.5
Onchocerca volvulus 0.0052 0.0237 0.0715
Loa Loa (eye worm) norepinephrine transporter 0.0557 0.3316 0.5023
Echinococcus granulosus dro:myosuppressin receptor 0.0052 0.0237 0.0237
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0094 0.0495 0.075
Loa Loa (eye worm) hypothetical protein 0.0094 0.0495 0.075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0237 0.0715
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0021 0.0047 0.0318
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0052 0.0237 0.0715
Onchocerca volvulus 0.0052 0.0237 0.0715
Echinococcus granulosus sex peptide receptor 0.0052 0.0237 0.0237
Onchocerca volvulus 0.0052 0.0237 0.0715
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0141 0.0956
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 0.0237 0.0715
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0938 0.2829
Onchocerca volvulus 0.0052 0.0237 0.0715
Echinococcus multilocularis serotonin receptor 0.0052 0.0237 0.0237
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0094 0.0495 0.0495
Trichomonas vaginalis dynamin, putative 0.0021 0.0047 0.0318
Plasmodium falciparum amino acid transporter, putative 0.0094 0.0495 1
Echinococcus granulosus dynamin 1 protein 0.0021 0.0047 0.0047
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 0.0237 0.0359
Brugia malayi nuclear receptor RXR 0.0032 0.0114 0.0173
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Echinococcus multilocularis tumor protein p63 0.0333 0.1952 0.1952
Echinococcus multilocularis thyroid hormone receptor alpha 0.0061 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Brugia malayi Serotonin receptor 0.0052 0.0237 0.0359
Brugia malayi G-protein coupled receptor 0.0052 0.0237 0.0359
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0318 0.1859 0.5606
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0097 0.0513 0.0777
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0289 0.0873
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0052 0.0237 0.0715
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Onchocerca volvulus 0.0052 0.0237 0.0715
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0318 0.1859 0.1859
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0094 0.0495 0.075
Brugia malayi hypothetical protein 0.0233 0.1342 0.2032
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0237 0.0237
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.0094 0.0495 0.075
Brugia malayi hypothetical protein 0.0052 0.0237 0.0359
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0141 0.0956
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0094 0.0495 0.8331
Echinococcus multilocularis somatostatin receptor 0.0052 0.0237 0.0237
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0061 0.0289 0.0289
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.0213
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Schistosoma mansoni nuclear receptor 0.0029 0.0093 0.0282
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0938 0.6371
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.1473 1
Echinococcus granulosus somatostatin receptor 0.0052 0.0237 0.0237
Schistosoma mansoni cpg binding protein 0.0028 0.0091 0.0275
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0289 0.0289
Schistosoma mansoni sodium/chloride dependent transporter 0.0094 0.0495 0.1493
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0093 0.0142
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0094 0.0495 0.0495
Echinococcus multilocularis dynamin 0.0021 0.0047 0.0047
Brugia malayi putative neuropeptide receptor 0.0052 0.0237 0.0359
Brugia malayi Dopamine receptor protein 2 0.0052 0.0237 0.0359
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0094 0.0495 0.1493
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0237 0.0237
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0094 0.0495 0.0495
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 0.0237 0.0359
Brugia malayi hypothetical protein 0.0052 0.0237 0.0359
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0237 0.0237
Brugia malayi hypothetical protein 0.0029 0.0093 0.0142
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.046 0.2729 0.4134
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0141 0.0956
Onchocerca volvulus Bile acid receptor homolog 0.0061 0.0289 0.0873
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.0213
Echinococcus multilocularis neuropeptide s receptor 0.0052 0.0237 0.0237
Loa Loa (eye worm) DRP-1 protein 0.0021 0.0047 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0061 0.0289 0.0438
Brugia malayi ORL1-like opioid receptor 0.0052 0.0237 0.0359
Echinococcus granulosus dynamin 0.0021 0.0047 0.0047
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0052 0.0237 0.0359
Brugia malayi steroid hormone receptor 0.0061 0.0289 0.0438
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1342 0.1342
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0093 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0201 0.0605
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0003 0.0003
Schistosoma mansoni RAR-like nuclear receptor 0.0061 0.0289 0.0873
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0237 0.0715
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0237 0.0715
Brugia malayi hypothetical protein 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Loa Loa (eye worm) hypothetical protein 0.056 0.3335 0.5051
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 0.0237 0.0237
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Schistosoma mansoni neuropeptide receptor 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0141 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Onchocerca volvulus Neuropeptide F receptor homolog 0.0052 0.0237 0.0715
Echinococcus granulosus dnaJ subfamily B 0.0403 0.238 0.238
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.0213
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0093 0.0142
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0237 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0061 0.0289 0.0438
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0061 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0094 0.0495 0.075
Brugia malayi Dynamin 0.0023 0.0057 0.0086
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0237 0.0715
Onchocerca volvulus 0.0094 0.0495 0.1493
Echinococcus granulosus voltage dependent calcium channel 0.0318 0.1859 0.1859
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 0.0237 0.0237
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0093 0.0282
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 0.0237 0.0715
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0318 0.1859 0.5606
Schistosoma mansoni hypothetical protein 0.0051 0.023 0.0693
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Brugia malayi hypothetical protein 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.046 0.2729 0.4134
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0003 0.0005
Echinococcus multilocularis allatostatin A receptor 0.0052 0.0237 0.0237
Schistosoma mansoni retinoic acid receptor RXR 0.0061 0.0289 0.0873
Onchocerca volvulus 0.0052 0.0237 0.0715
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0285 0.086
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0094 0.0495 0.0495
Schistosoma mansoni amine GPCR 0.0052 0.0237 0.0715
Onchocerca volvulus 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Loa Loa (eye worm) solute carrier family 6 member 4 0.0557 0.3316 0.5023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0061 0.0289 0.0438
Onchocerca volvulus 0.0052 0.0237 0.0715
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0209 0.0316
Brugia malayi larval opioid receptor 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0237 0.0715
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 0.0237 0.0359
Trichomonas vaginalis dynamin, putative 0.0021 0.0047 0.0318
Plasmodium vivax amine transporter, putative 0.0094 0.0495 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0201 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0061 0.0289 0.0438
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0237 0.0715
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0061 0.0289 0.0438
Loa Loa (eye worm) TYRA-2 protein 0.0052 0.0237 0.0359
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.0213
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0289 0.0438
Onchocerca volvulus 0.0048 0.0209 0.0629
Brugia malayi Dopamine receptor 0.0052 0.0237 0.0359
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0094 0.0495 0.1493
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0318 0.1859 0.1859
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0094 0.0495 0.1493
Schistosoma mansoni hypothetical protein 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0061 0.0289 0.0438
Brugia malayi Cytochrome P450 family protein 0.0022 0.0055 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0061 0.0289 0.0438
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0093 0.0142
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0201 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0289 0.0438
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0111 0.0594 0.09
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 0.0237 0.0237
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0237 0.0237
Brugia malayi Cytochrome P450 family protein 0.0014 0.0003 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0237 0.0715
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Brugia malayi hypothetical protein 0.0052 0.0237 0.0359
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0093 0.0282
Onchocerca volvulus 0.0094 0.0495 0.1493
Trichomonas vaginalis dynamin, putative 0.0021 0.0047 0.0318
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0003 0.0005
Giardia lamblia Dynamin 0.0021 0.0047 0.5
Echinococcus multilocularis geminin 0.0167 0.0938 0.0938
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0093 0.0142
Brugia malayi G protein-coupled receptor 0.0052 0.0237 0.0359
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0216 0.0652
Onchocerca volvulus 0.0061 0.0289 0.0873
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0237 0.0237
Brugia malayi nuclear receptor RXR 0.0029 0.0093 0.0142
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0359
Onchocerca volvulus 0.0052 0.0237 0.0715
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0557 0.3316 0.5023
Loa Loa (eye worm) calcium channel 0.0318 0.1859 0.2816
Loa Loa (eye worm) hypothetical protein 0.0318 0.1859 0.2816
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0237 0.0237
Schistosoma mansoni hypothetical protein 0.0167 0.0938 0.2829
Loa Loa (eye worm) hypothetical protein 0.0111 0.0594 0.09
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0061 0.0289 0.0438
Toxoplasma gondii dynamin gtpase 0.0014 0.0003 0.0051
Echinococcus multilocularis sex peptide receptor 0.0052 0.0237 0.0237
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0114 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0201 0.0201
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0237 0.0237
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0141 0.2367
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0938 0.6371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0061 0.0289 0.0438
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0993 0.6744
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0237 0.0715
Echinococcus granulosus G protein coupled receptor 139 0.0052 0.0237 0.0237
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0061 0.0289 0.0289
Brugia malayi hypothetical protein 0.0032 0.0114 0.0173
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.0114 0.0345
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0237 0.0237
Brugia malayi nuclear hormone receptor 0.0061 0.0289 0.0438
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0061 0.0289 0.0873
Leishmania major C-8 sterol isomerase-like protein 0.1095 0.6602 1
Schistosoma mansoni hypothetical protein 0.0043 0.0184 0.0554
Schistosoma mansoni amine GPCR 0.0052 0.0237 0.0715
Toxoplasma gondii hypothetical protein 0.0094 0.0495 0.8331
Echinococcus multilocularis serotonin receptor 0.0052 0.0237 0.0237
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0052 0.0237 0.0237
Brugia malayi hypothetical protein 0.0043 0.0184 0.0278

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.