Detailed information for compound 1312541

Basic information

Technical information
  • TDR Targets ID: 1312541
  • Name: 5-(2,5-dichlorophenyl)-N-(2,5-dimethylphenyl) furan-2-carboxamide
  • MW: 360.234 | Formula: C19H15Cl2NO2
  • H donors: 1 H acceptors: 1 LogP: 5.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl)C
  • InChi: 1S/C19H15Cl2NO2/c1-11-3-4-12(2)16(9-11)22-19(23)18-8-7-17(24-18)14-10-13(20)5-6-15(14)21/h3-10H,1-2H3,(H,22,23)
  • InChiKey: ADEIWISNTUOOEM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(2,5-dichlorophenyl)-N-(2,5-dimethylphenyl)-2-furancarboxamide
  • 5-(2,5-dichlorophenyl)-N-(2,5-dimethylphenyl)-2-furamide
  • Oprea1_143483
  • ZINC00848990
  • Oprea1_396142
  • 5-(2,5-Dichloro-phenyl)-furan-2-carboxylic acid (2,5-dimethyl-phenyl)-amide
  • BAS 01064652

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sphingosine-1-phosphate receptor 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0071 0.0232
Onchocerca volvulus 0.0187 0.0536 0.175
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0215 0.0701
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0012 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0052 0.0194
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0002 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0068 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0052 0.0194
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0052 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0096 0.0313
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0052 0.017
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0126 0.0345 0.6442
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0047
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0052 0.0192
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0021
Schistosoma mansoni tar DNA-binding protein 0.019 0.0546 0.2011
Schistosoma mansoni hypothetical protein 0.0886 0.2715 1
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.0002 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0062 0.0201
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0096 0.1112
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0111 0.2062
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0111 0.2062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0296 0.0877 0.3266
Schistosoma mansoni hypothetical protein 0.0203 0.0585 0.2154
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0164 0.0609
Onchocerca volvulus 0.0047 0.01 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0021
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0111 0.2062
Schistosoma mansoni patched 1 0.0084 0.0215 0.0791
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1446 0.446 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0296 0.0877 0.3266
Schistosoma mansoni tar DNA-binding protein 0.019 0.0546 0.2011
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0063 0.0125
Loa Loa (eye worm) beta-lactamase 0.0187 0.0536 0.1996
Echinococcus granulosus lamin dm0 0.0029 0.0043 0.0158
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0052 0.0194
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0002 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0042 0.0137
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0052 0.0192
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0052 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0111
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0077 0.0194 0.2252
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.0091 0.106
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0002 0.0009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.01 0.1162
Entamoeba histolytica hypothetical protein 0.002 0.0014 0.0166
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0069 0.1282
Mycobacterium leprae conserved hypothetical protein 0.0187 0.0536 0.1174
Loa Loa (eye worm) hypothetical protein 0.0148 0.0414 0.154
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0048
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0064 0.0127
Leishmania major DNA polymerase eta, putative 0.0031 0.005 0.0941
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0007 0.0135
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.033 0.1228
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0015 0.0000034684 0.0000034684
Brugia malayi RNA binding protein 0.019 0.0546 0.2034
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0052 0.0194
Onchocerca volvulus 0.002 0.0014 0.0047
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0013 0.0243
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0241
Trypanosoma brucei hypothetical protein, conserved 0.0187 0.0536 1
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0012 0.0045
Chlamydia trachomatis DNA ligase 0.002 0.0014 0.1266
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0007 0.0204
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0077 0.089
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.055 0.2027
Loa Loa (eye worm) hypothetical protein 0.0195 0.0562 0.2094
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0013 0.0243
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0094 0.0246 0.0905
Brugia malayi SET domain containing protein 0.0016 0.0002 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.01 0.1866
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0052 0.0194
Leishmania major hypothetical protein, conserved 0.0129 0.0356 0.6637
Leishmania major DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0007 0.0135
Loa Loa (eye worm) hypothetical protein 0.0187 0.0536 0.1996
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0013 0.0048
Loa Loa (eye worm) hypothetical protein 0.0044 0.0092 0.0341
Onchocerca volvulus 0.0998 0.3063 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.01 0.0208
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0043 0.016
Echinococcus multilocularis lamin 0.0029 0.0043 0.0043
Brugia malayi beta-lactamase family protein 0.0187 0.0536 0.1996
Schistosoma mansoni chromobox protein 0.0067 0.0164 0.0602
Echinococcus granulosus lamin 0.0029 0.0043 0.0158
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0069 0.0256
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0002 0.0009
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0029 0.0042 0.0788
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0111 0.0361
Loa Loa (eye worm) hypothetical protein 0.0103 0.0274 0.1018
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0014 0.0047
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0014 0.0267
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0012 0.0229
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0002 0.0002
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0111 0.0111
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0052 0.017
Brugia malayi RNA recognition motif domain containing protein 0.019 0.0546 0.2034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0094 0.0246 0.0915
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0091 0.0236 0.2743
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0014 0.0014
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0013 0.0042
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0012 0.0229
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0014 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0373
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0096 0.0253 0.2943
Echinococcus granulosus GPCR family 2 0.0094 0.0246 0.0905
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0069 0.0256
Brugia malayi ecdysteroid receptor 0.0032 0.0052 0.0194
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0464 0.1401 0.5215
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0052 0.0052
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0077 0.0156
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0077 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0009
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0002 0.0009
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0096 0.0253 0.0827
Mycobacterium tuberculosis Conserved protein 0.0187 0.0536 0.1188
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0052 0.0192
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0034 0.006 0.0194
Echinococcus multilocularis GPCR, family 2 0.0094 0.0246 0.0246
Onchocerca volvulus 0.0029 0.0043 0.014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0069 0.1282
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0069 0.0224
Brugia malayi PHD-finger family protein 0.0019 0.0013 0.0049
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0136 0.2532
Trypanosoma cruzi PAB1-binding protein , putative 0.0129 0.0356 0.6637
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0194
Loa Loa (eye worm) TAR-binding protein 0.019 0.0546 0.2034
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0002 0.0002
Loa Loa (eye worm) inositol-1 0.004 0.0077 0.0285
Echinococcus multilocularis survival motor neuron protein 1 0.0464 0.1401 0.1401
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0308 0.066
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0194
Schistosoma mansoni hypothetical protein 0.0094 0.0246 0.0905
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0034 0.006 0.111
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0046
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0136 0.2532
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0082 0.021 0.0782
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0067 0.0162 0.0529
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0014 0.0016
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0096 0.0353
Brugia malayi hypothetical protein 0.0017 0.0006 0.0021
Mycobacterium ulcerans esterase/lipase LipP 0.0187 0.0536 0.1188
Entamoeba histolytica G protein alpha subunit, putative 0.0016 0.0002 0.0028
Echinococcus multilocularis lamin dm0 0.0029 0.0043 0.0043
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0096 0.0253 0.4727
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0052 0.0192
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0014 0.0047
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0069 0.4783
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0007 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0052 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0052 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0052 0.0194
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0164 0.0534
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0007 0.0027
Schistosoma mansoni metabotropic glutamate receptor 0.0033 0.0057 0.0211
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0109 0.0109
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0012 0.0045
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0007 0.0027
Schistosoma mansoni transcription factor LCR-F1 0.0291 0.0861 0.3171
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0016 0.0002 0.0008
Mycobacterium ulcerans lipase LipD 0.0187 0.0536 0.1188
Onchocerca volvulus 0.0029 0.0043 0.014
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0012 0.0012
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0096 0.1786
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0052 0.0192
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0111 0.2062
Plasmodium falciparum ataxin-2 like protein, putative 0.0129 0.0356 1
Leishmania major DNA polymerase eta, putative 0.0044 0.0092 0.1707
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0052 0.0194
Brugia malayi DKFZp564C0469 protein 0.002 0.0014 0.0053
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0052 0.0192
Loa Loa (eye worm) glutamate receptor 0.0016 0.0002 0.0008
Toxoplasma gondii thioredoxin reductase 0.005 0.0109 0.2029
Loa Loa (eye worm) hypothetical protein 0.0187 0.0536 0.1996
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0012 0.0012
Mycobacterium ulcerans hypothetical protein 0.0047 0.01 0.0208
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0013 0.0013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0094 0.0246 0.0915
Mycobacterium tuberculosis Probable lipase LipD 0.0187 0.0536 0.1188
Schistosoma mansoni hypothetical protein 0.0058 0.0134 0.0493
Onchocerca volvulus 0.0148 0.0414 0.1351
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0052 0.0192
Brugia malayi hypothetical protein 0.0017 0.0006 0.0021
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0014 0.0047
Loa Loa (eye worm) hypothetical protein 0.0084 0.0215 0.08
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0164 0.0534
Brugia malayi Bromodomain containing protein 0.0059 0.0136 0.0505
Brugia malayi hypothetical protein 0.0129 0.0356 0.1325
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0012 0.0012
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0006 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0052 0.0194
Schistosoma mansoni lamin 0.0029 0.0043 0.0158
Brugia malayi hypothetical protein 0.0148 0.0414 0.154
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.0521 0.1701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0068 0.0223
Schistosoma mansoni hypothetical protein 0.0094 0.0246 0.0905
Loa Loa (eye worm) hypothetical protein 0.0203 0.0585 0.2178
Echinococcus granulosus replication factor c subunit 1 0.002 0.0014 0.0053
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0126 0.0345 0.0345
Schistosoma mansoni hypothetical protein 0.0081 0.0205 0.0756
Schistosoma mansoni hypothetical protein 0.0081 0.0205 0.0756
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0037 0.012
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0007 0.0027
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0069 0.1278
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0069 0.8861
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0013 0.0042
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0013 0.015
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0002 0.0002
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0179 0.051 0.1878
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0063 0.0125
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0007 0.0025
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0096 0.0353
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0094 0.0246 0.0246
Toxoplasma gondii ABC1 family protein 0.0187 0.0536 1
Echinococcus granulosus expressed protein 0.0016 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0009
Plasmodium vivax JmjC domain containing protein 0.0019 0.0012 0.0229
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0366 0.1094 0.4075
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0014 0.1017
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0308 0.0675
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0014 0.0267
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0347 0.0764
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0111 0.2062
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.006 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0042 0.0137
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0069 0.1282
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0069 0.0138
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.01 0.0208
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0007 0.0024
Schistosoma mansoni hypothetical protein 0.0019 0.0013 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Trichomonas vaginalis chromobox protein, putative 0.0041 0.008 0.0262
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0002 0.0008
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0069 0.1278
Onchocerca volvulus 0.0016 0.0002 0.0008
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0046
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0187 0.0536 0.1188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0007 0.0022
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0046
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0062 0.1147
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0063 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0373
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0063 0.1175
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0215 0.0791
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0241
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0014 0.0402
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.01 0.1866
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0049
Brugia malayi steroid hormone receptor 0.0032 0.0052 0.0194
Loa Loa (eye worm) hypothetical protein 0.0126 0.0345 0.1286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0007 0.0135
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.0331 0.1219
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0007 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0062 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0366 0.1094 0.4031
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0053
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0096 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0014 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0111
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0096 0.0253 0.0827
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0096 0.0357
Echinococcus granulosus beta LACTamase domain containing family member 0.0187 0.0536 0.1974
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0111 0.2062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0068 0.0223
Schistosoma mansoni hypothetical protein 0.0094 0.0246 0.0905
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.0134 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0062 0.0201
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0235
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0053
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0034 0.006 0.0194
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0136 0.0136
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0096 0.1786
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0068 0.0223
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0194
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0235
Plasmodium vivax SET domain protein, putative 0.0126 0.0345 0.6442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.0094 0.0246 0.0915
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.01 0.0193
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0063 0.0151 0.0561
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0194
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0094 0.0246 0.0905
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0007 0.0135
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0052 0.0192
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0016 0.0002 0.0008
Plasmodium vivax glutathione reductase, putative 0.005 0.0109 0.2029
Loa Loa (eye worm) glutamate receptor 0.004 0.0077 0.0288
Trypanosoma brucei unspecified product 0.0019 0.0013 0.0241
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0052 0.0194
Loa Loa (eye worm) hypothetical protein 0.0049 0.0106 0.0394
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.0536 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0015 0.0000034684 0.0000034684
Brugia malayi glutathione reductase 0.005 0.0109 0.0405
Trypanosoma brucei protein kinase, putative 0.005 0.0111 0.2062
Brugia malayi Heterochromatin protein 1 0.0067 0.0164 0.0609
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0007 0.0007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0069 0.0138
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0069 0.0224
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0373
Brugia malayi nuclear receptor NHR-88 0.0032 0.0052 0.0194
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.0562 0.6532
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0136 0.2532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0112
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0109 0.0401
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0007 0.0128
Schistosoma mansoni ap endonuclease 0.0037 0.0069 0.0253
Loa Loa (eye worm) hypothetical protein 0.0182 0.0521 0.194
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.0562 0.2071
Brugia malayi Calcitonin receptor-like protein seb-1 0.0296 0.0877 0.3266
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0187 0.0536 0.1996
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0012 0.0045
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0012 0.0045
Mycobacterium tuberculosis Probable hydrolase 0.0187 0.0536 0.1188
Giardia lamblia Replication factor C, subunit 1 0.002 0.0014 0.0549
Entamoeba histolytica hypothetical protein 0.0291 0.0861 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.0536 0.1996
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0174 0.0641
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0179 0.051 0.051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.0134 0.0134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0007 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Brugia malayi Inositol-1 0.004 0.0077 0.0285
Brugia malayi TAR-binding protein 0.019 0.0546 0.2034
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0207 0.0207
Brugia malayi Thioredoxin reductase 0.005 0.0109 0.0405
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0013 0.0241
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0002 0.0009
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0034 0.006 0.0219
Treponema pallidum DNA ligase (lig) 0.002 0.0014 0.1148
Brugia malayi MH2 domain containing protein 0.0127 0.0349 0.13
Echinococcus multilocularis expressed protein 0.0016 0.0002 0.0002
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0002 0.0009
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0111 0.0407
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0347 0.0764
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.0562 0.2094
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.01 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0052 0.0194
Entamoeba histolytica hypothetical protein 0.0291 0.0861 1
Schistosoma mansoni lamin 0.0029 0.0043 0.0158
Plasmodium vivax ataxin-2 like protein, putative 0.0129 0.0356 0.6637
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0052 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0069 0.1282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0366 0.1094 0.4031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0007 0.0135
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0006 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0007 0.0022
Leishmania major trypanothione reductase 0.005 0.0109 0.2029
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0136 0.05
Loa Loa (eye worm) hypothetical protein 0.0129 0.0356 0.1325
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0027 0.0101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0057 0.0112
Echinococcus granulosus tar DNA binding protein 0.019 0.0546 0.2011
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0033 0.0057 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.0536 0.175
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0007 0.0024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0052 0.0052
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0347 0.0764
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0002 0.0009
Echinococcus granulosus peregrin 0.0059 0.0136 0.05
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.01 0.1162
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0069 0.1282
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0096 0.0253 0.4727
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0345 0.1272
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0007 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0096 0.0313
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0136 0.05
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.01 0.1866
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0043 0.016
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0006 0.0006
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0014 0.0267
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0016 0.0002 0.0009
Schistosoma mansoni hypothetical protein 0.0291 0.0861 0.3171
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0094 0.0347
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0016 0.0002 0.0009
Echinococcus granulosus survival motor neuron protein 1 0.0464 0.1401 0.5158
Echinococcus multilocularis nibrin 0.002 0.0014 0.0014
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0136 0.0505
Echinococcus granulosus phd:f box containing protein 0.0019 0.0012 0.0045
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0215 0.08
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0052 0.0194
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0014 0.0166
Trypanosoma brucei PAB1-binding protein , putative 0.0129 0.0356 0.6637
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0018 0.0328
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0052 0.0052
Brugia malayi CHE-14 protein 0.0084 0.0215 0.08
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0047
Onchocerca volvulus 0.0187 0.0536 0.175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0111
Trypanosoma brucei trypanothione reductase 0.005 0.0109 0.2029
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0016 0.0002 0.0009
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0013 0.0013
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0347 0.0749
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0007 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0057 0.0112
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0016 0.0002 0.0008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0034 0.006 0.0691
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0096 0.0357
Onchocerca volvulus 0.0137 0.038 0.124
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0092 0.0341
Schistosoma mansoni topbp1 0.002 0.0014 0.0053
Echinococcus granulosus geminin 0.0886 0.2715 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0007 0.0135
Loa Loa (eye worm) phosphatidylinositol 3 0.0029 0.0042 0.0157
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0069 0.0253
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0235
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0052 0.0192
Echinococcus granulosus nibrin 0.002 0.0014 0.0053
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0002 0.0009
Echinococcus granulosus metabotropic glutamate receptor 5 0.0049 0.0106 0.039
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0077 0.0282
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0174 0.0641
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0092 0.1707
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0013 0.0243
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0069 0.0069
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0012 0.0012
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0077 0.1429
Schistosoma mansoni metabotropic glutamate receptor 0.0019 0.0014 0.0051
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0014 0.0267
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0052 0.0192
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0016 0.0002 0.0009
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0014 0.0053
Loa Loa (eye worm) RNA binding protein 0.019 0.0546 0.2034
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0069 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0187 0.0536 0.1996
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0016 0.0002 0.0009
Mycobacterium leprae Probable lipase LipE 0.0187 0.0536 0.1174
Mycobacterium tuberculosis Conserved protein 0.0187 0.0536 0.1188
Brugia malayi N-terminal motif family protein 0.0182 0.0521 0.194
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0052 0.0052
Leishmania major hypothetical protein, conserved 0.0019 0.0012 0.0229
Schistosoma mansoni hypothetical protein 0.0081 0.0205 0.0756
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0052 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0062 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0366 0.1094 0.4031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0112
Brugia malayi hypothetical protein 0.0291 0.0861 0.3206
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.01 0.0208
Schistosoma mansoni inositol monophosphatase 0.004 0.0077 0.0282
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0014 0.0267
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0002 0.0002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0069 0.0798
Echinococcus granulosus dna polymerase kappa 0.0019 0.0013 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0006 0.0021
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0092 0.1707
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0096 0.1786
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0111 0.0407
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0111 0.8041
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0007 0.0135
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0265
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0007 0.0128
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0052 0.0192
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0006 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0042 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0046
Onchocerca volvulus 0.003 0.0046 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0041 0.0134
Echinococcus multilocularis musashi 0.0029 0.0043 0.0043
Brugia malayi hypothetical protein 0.002 0.0014 0.0053
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0215 0.0215
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0052 0.0192
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.017
Brugia malayi jmjC domain containing protein 0.0071 0.0174 0.0648
Plasmodium falciparum glutathione reductase 0.005 0.0109 0.3057
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0016 0.0002 0.0002
Echinococcus multilocularis expressed conserved protein 0.0184 0.0525 0.0525
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0037 0.012
Loa Loa (eye worm) hypothetical protein 0.0187 0.0536 0.1996
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0014 0.0267
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0109 0.0405
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.01 0.0193
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0007 0.0135
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0096 0.1112
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0077 0.1429
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0016 0.0002 0.0009
Brugia malayi follicle stimulating hormone receptor 0.0464 0.1399 0.5208
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0187 0.0536 0.1974
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0111 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0052 0.0169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0007 0.0135
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0052 0.0052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0057 0.0112
Echinococcus granulosus microtubule associated protein 2 0.0734 0.2241 0.8253
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0007 0.0135
Loa Loa (eye worm) hypothetical protein 0.0059 0.0136 0.0505
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.0824 0.0824
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0016 0.0002 0.0009
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0002 0.0009
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.0066 0.0245
Brugia malayi AF-10 protein 0.0019 0.0013 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0062 0.0201
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0012 0.0045
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.005 0.0941
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0109 0.2029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0096 0.0253 0.0944
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0174 0.0641
Echinococcus granulosus dna polymerase eta 0.0044 0.0092 0.0337
Echinococcus granulosus chromobox protein 1 0.0067 0.0164 0.0602
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0877 0.2686 1
Plasmodium falciparum phd finger protein, putative 0.0059 0.0136 0.3814
Loa Loa (eye worm) glutathione reductase 0.005 0.0109 0.0405
Trichomonas vaginalis penicillin-binding protein, putative 0.0187 0.0536 0.175
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0012 0.0046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0062 0.0201
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0077 1
Brugia malayi latrophilin 2 splice variant baaae 0.0203 0.0585 0.2178
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0013 0.0013
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1446 0.446 1
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0207 0.0763
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0291 0.0861 0.3171
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0111 0.0111
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0067 0.0162 0.0529
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0002 0.0009
Brugia malayi MAP kinase sur-1 0.005 0.0111 0.0412
Schistosoma mansoni hypothetical protein 0.0095 0.0249 0.0916
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0052 0.0192
Echinococcus granulosus expressed conserved protein 0.0184 0.0525 0.1935
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0025 0.003 0.1784
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0046
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0096 0.1786
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0291 0.0861 0.0861
Echinococcus multilocularis beta LACTamase domain containing family member 0.0187 0.0536 0.0536
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0071 0.0232
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0137 0.038 0.1398
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0187 0.0536 0.1188
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0013
Mycobacterium tuberculosis Probable lipase LipE 0.0187 0.0536 0.1188
Schistosoma mansoni microtubule-associated protein tau 0.0734 0.2241 0.8253
Echinococcus multilocularis geminin 0.0886 0.2715 0.2715
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0052 0.0194
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0308 0.0675
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0053
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0016 0.0002 0.0009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.019 0.0546 0.2034
Entamoeba histolytica hypothetical protein 0.0291 0.0861 1
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0002 0.0009
Schistosoma mansoni tar DNA-binding protein 0.019 0.0546 0.2011
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0012 0.0045
Brugia malayi hypothetical protein 0.0083 0.0213 0.0794
Brugia malayi PHD-finger family protein 0.0059 0.0136 0.0505
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0002 0.0009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0126 0.0345 0.0345
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.01 0.0208
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0077 0.025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0052 0.0194
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0308 0.0675
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0063 0.0151 0.0555
Mycobacterium tuberculosis Conserved protein 0.0187 0.0536 0.1188
Echinococcus multilocularis protein dispatched 1 0.0096 0.0252 0.0252
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0052 0.0192
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0111 0.2062
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0007 0.0135
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0043 0.016
Trichomonas vaginalis set domain proteins, putative 0.0998 0.3063 1
Onchocerca volvulus 0.0016 0.0002 0.0008
Loa Loa (eye worm) G protein alpha subunit 3 0.0016 0.0002 0.0009
Entamoeba histolytica hypothetical protein 0.0077 0.0194 0.2252
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0052 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0366 0.1094 0.1094
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0013 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0016 0.0002 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0047 0.01 0.0373
Schistosoma mansoni hypothetical protein 0.0081 0.0205 0.0756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0112
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0002 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0052 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Schistosoma mansoni jumonji domain containing protein 0.0152 0.0428 0.1575
Onchocerca volvulus 0.0032 0.0052 0.017
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0094 0.0246 0.0246
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0007 0.0135
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0111 0.2062
Loa Loa (eye worm) hypothetical protein 0.0063 0.0151 0.0561
Schistosoma mansoni DNA ligase IV 0.002 0.0014 0.0053
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0366 0.1094 0.4075
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0052 0.0194
Echinococcus multilocularis peregrin 0.0059 0.0136 0.0136
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0109 0.0228
Trichomonas vaginalis penicillin-binding protein, putative 0.0187 0.0536 0.175
Brugia malayi G-protein alpha subunit 0.0016 0.0002 0.0009
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0016 0.0002 0.0009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.01 0.1162
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0349 0.13
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0076 0.0249
Schistosoma mansoni chromobox protein 0.0067 0.0164 0.0602
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0007 0.0128
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0077 0.1429
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0194
Trichomonas vaginalis esterase, putative 0.0187 0.0536 0.175
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0002 0.0009
Toxoplasma gondii exonuclease III APE 0.0037 0.0069 0.1282
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0048
Schistosoma mansoni survival motor neuron protein 0.0095 0.0249 0.0916
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0069 0.1278
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0007 0.0135
Mycobacterium ulcerans transcriptional regulator 0.1446 0.446 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0112
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0047
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0077 0.025
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.0824 0.3033
Brugia malayi Pre-SET motif family protein 0.0126 0.0345 0.1286
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.01 0.0208
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0052 0.0192
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0002 0.0009
Schistosoma mansoni inositol monophosphatase 0.004 0.0077 0.0282
Giardia lamblia DINP protein human, muc B family 0.0019 0.0013 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0068 0.0223
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.005 0.0941
Mycobacterium tuberculosis Probable reductase 0.0114 0.0308 0.0675
Brugia malayi chromobox protein homolog 3 0.0038 0.0071 0.0265
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0052 0.0192
Brugia malayi intermediate filament protein 0.0029 0.0043 0.016
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0308 0.0675
Echinococcus granulosus metabotropic glutamate receptor 2 0.0033 0.0057 0.0211
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0025 0.0471
Schistosoma mansoni tar DNA-binding protein 0.019 0.0546 0.2011
Toxoplasma gondii LsmAD domain-containing protein 0.0129 0.0356 0.6637
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.0562 0.0562
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0013 0.0243
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0007 0.0204
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0052 0.0192
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.0002 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0007 0.0022
Schistosoma mansoni intermediate filament proteins 0.0029 0.0043 0.0158
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0052 0.0192
Brugia malayi hypothetical protein 0.0016 0.0002 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.0129 0.0356 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0012 0.0229
Brugia malayi Pre-SET motif family protein 0.0877 0.2686 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0069 0.1931
Echinococcus granulosus chromobox protein 1 0.0067 0.0164 0.0602
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0007 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0053
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0077 0.1429
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0034 0.006 0.0691
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1446 0.446 1
Plasmodium vivax hypothetical protein, conserved 0.0187 0.0536 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0034 0.006 0.0194
Onchocerca volvulus Alhambra homolog 0.0059 0.0136 0.0443
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0052 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0052 0.0194
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0012 0.0045
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.016
Brugia malayi metabotropic glutamate receptor type 2 0.0019 0.0014 0.0051
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.01 0.0208
Brugia malayi beta-lactamase 0.0187 0.0536 0.1996
Brugia malayi AMP-binding enzyme family protein 0.0047 0.01 0.0373
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0013 0.0013
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0007 0.0007
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0007 0.0135
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0002 0.0008
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0179 0.051 0.1878
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0308 0.0675
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0187 0.0536 0.1996
Plasmodium falciparum glutathione reductase 0.0017 0.0007 0.0204
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0109 0.2029
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0013 0.0013
Brugia malayi topoisomerase 0.002 0.0014 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0187 0.0536 0.1974
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0345 0.1272
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0249 0.0926
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0007 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0041 0.0134
Onchocerca volvulus 0.0095 0.0249 0.0812
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0049 0.0106 0.0106
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0012 0.0229
Echinococcus multilocularis chromobox protein 1 0.0067 0.0164 0.0164
Echinococcus multilocularis chromobox protein 1 0.0067 0.0164 0.0164
Entamoeba histolytica hypothetical protein 0.0291 0.0861 1
Mycobacterium ulcerans hypothetical protein 0.0187 0.0536 0.1188
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0007 0.0135
Loa Loa (eye worm) hypothetical protein 0.0187 0.0536 0.1996
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.01 0.0208
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0077 0.025
Brugia malayi Latrophilin receptor protein 2 0.0094 0.0246 0.0915
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0002 0.0009
Schistosoma mansoni hypothetical protein 0.0059 0.0136 0.05
Mycobacterium tuberculosis Probable esterase LipL 0.0187 0.0536 0.1188
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0048 0.0103 0.7425
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0187 0.0536 0.1188
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0349 0.13
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0046
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0063 0.177
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0096 0.0253 0.0827
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0111 0.0361
Schistosoma mansoni hypothetical protein 0.0886 0.2715 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0096 0.1786
Schistosoma mansoni DNA polymerase eta 0.0044 0.0092 0.0337
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0002 0.0009
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0187 0.0536 0.1188
Mycobacterium ulcerans beta-lactamase 0.0187 0.0536 0.1188
Brugia malayi AMP-binding enzyme family protein 0.0047 0.01 0.0373
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0001 0.0005
Brugia malayi hypothetical protein 0.0464 0.1401 0.5215
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.0536 0.175
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0174 0.0648
Trypanosoma cruzi PAB1-binding protein , putative 0.0129 0.0356 0.6637
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0014 0.0267
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0007 0.0128
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0016 0.0002 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0096 0.0313
Schistosoma mansoni hypothetical protein 0.0094 0.0246 0.0905
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0052 0.0194
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0077 0.1429
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0345 0.1272
Echinococcus multilocularis protein patched 0.0084 0.0215 0.0215
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0063 1
Brugia malayi nuclear hormone receptor 0.0032 0.0052 0.0194
Onchocerca volvulus 0.0187 0.0536 0.175
Onchocerca volvulus 0.0016 0.0002 0.0008
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0002 0.0009
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.0572 0.2106
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0006 0.0021
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0077 0.0288
Giardia lamblia PHD finger protein 15 0.0059 0.0136 1
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0014 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0366 0.1094 0.4031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0052 0.0194
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0012 0.0045
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0064 0.0111
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0027 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0241
Brugia malayi nuclear receptor RXR 0.0017 0.0006 0.0021
Plasmodium falciparum thioredoxin reductase 0.005 0.0109 0.3057
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0013 0.0366
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0111 0.0407
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0006 0.0021
Echinococcus multilocularis tar DNA binding protein 0.019 0.0546 0.0546
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0366 0.1094 0.4031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0049 0.0159
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0014 0.0047
Echinococcus granulosus histone lysine methyltransferase setb 0.0126 0.0345 0.1272
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0012 0.0345
Schistosoma mansoni ap endonuclease 0.0037 0.0069 0.0253
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0052 0.0192
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0009
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0007 0.0135
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0012 0.0229
Echinococcus multilocularis microtubule associated protein 2 0.0734 0.2241 0.2241
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0013 0.0048
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0052 0.0192
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0215 0.0791
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0007 0.0128
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0052 0.017
Echinococcus granulosus intermediate filament protein 0.0029 0.0043 0.0158
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0096 0.1786
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0014 0.0053
Echinococcus multilocularis dna polymerase eta 0.0044 0.0092 0.0092
Schistosoma mansoni topbp1 0.002 0.0014 0.0053
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0002 0.0009
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0034 0.006 0.111
Schistosoma mansoni coup transcription factor 0.0032 0.0052 0.0192
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.01 0.0208
Brugia malayi beta-lactamase family protein 0.0187 0.0536 0.1996
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0111 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0071 0.0232
Trichomonas vaginalis chromobox protein, putative 0.0041 0.008 0.0262
Brugia malayi jmjC domain containing protein 0.0192 0.055 0.205
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0053
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0012 0.0045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0366 0.1094 0.1094
Loa Loa (eye worm) hypothetical protein 0.01 0.0266 0.099
Schistosoma mansoni tar DNA-binding protein 0.019 0.0546 0.2011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0057 0.0112
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0111 0.0361
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0464 0.1399 0.5208
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.0536 0.175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0062 0.0201
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0013 0.0048
Loa Loa (eye worm) hypothetical protein 0.0296 0.0877 0.3266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0235
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0241
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0052 0.0052
Plasmodium falciparum thioredoxin reductase 0.0017 0.0007 0.0204
Brugia malayi hypothetical protein 0.002 0.0014 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0235
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0012 0.0012
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.055 0.055
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.008 0.0262
Giardia lamblia GTOR 0.0046 0.0096 0.6888
Leishmania major hypothetical protein, conserved 0.0187 0.0536 1
Loa Loa (eye worm) phosphatidylinositol 3 0.016 0.0451 0.1677
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0007 0.0135
Loa Loa (eye worm) hypothetical protein 0.0033 0.0056 0.0209
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0174 0.0174
Mycobacterium ulcerans TetR family transcriptional regulator 0.1446 0.446 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0194
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0016 0.0002 0.0009
Onchocerca volvulus 0.0022 0.0021 0.0068
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1195 0.3676 0.8239

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 165 nM Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay ChEMBL. 21570287
IC50 (functional) = 0.165 um PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)] ChEMBL. No reference
IC50 (functional) > 25 uM PUBCHEM_BIOASSAY: Late stage counterscreen assay for S1P4 antagonists: Fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 2 (S1P2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1510, AID1524, AID1692, AID1853, AID2332, AID489009, AID489017] ChEMBL. No reference
IC50 (functional) > 25 uM PUBCHEM_BIOASSAY: Late stage counterscreen assay for S1P4 antagonists: Fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 3 (S1P3). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1510, AID1524, AID1692, AID1853, AID2332, AID489009, AID489017] ChEMBL. No reference
IC50 (functional) > 25 uM PUBCHEM_BIOASSAY: Late stage counterscreen assay for S1P4 antagonists: Fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 5 (S1P5). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1510, AID1524, AID1692, AID1853, AID2332, AID489009, AID489017] ChEMBL. No reference
IC50 (functional) > 25 uM PUBCHEM_BIOASSAY: Late stage counterscreen assay for S1P4 antagonists: Fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 1 (S1P1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1510, AID1524, AID1692, AID1853, AID2332, AID489009, AID489017] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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