Detailed information for compound 1338499

Basic information

Technical information
  • TDR Targets ID: 1338499
  • Name: 1-(2-chlorophenothiazin-10-yl)-2-[[5-[(3-meth ylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfan yl]ethanone
  • MW: 496.001 | Formula: C24H18ClN3O3S2
  • H donors: 0 H acceptors: 3 LogP: 5.88 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)OCc1nnc(o1)SCC(=O)N1c2ccccc2Sc2c1cc(Cl)cc2
  • InChi: 1S/C24H18ClN3O3S2/c1-15-5-4-6-17(11-15)30-13-22-26-27-24(31-22)32-14-23(29)28-18-7-2-3-8-20(18)33-21-10-9-16(25)12-19(21)28/h2-12H,13-14H2,1H3
  • InChiKey: ACOQBFWIYQIFOF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-(2-chloro-10-phenothiazinyl)-2-[[5-[(3-methylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]thio]ethanone
  • 1-(2-chlorophenothiazin-10-yl)-2-[[5-[(3-methylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]thio]ethanone
  • Oprea1_407952
  • 1-(2-Chloro-phenothiazin-10-yl)-2-(5-m-tolyloxymethyl-[1,3,4]oxadiazol-2-ylsulfanyl)-ethanone
  • MLS000559818
  • SMR000172606
  • ASN 03323273

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2487 1
Echinococcus multilocularis fmrfamide receptor 0.0078 0.2515 0.2515
Brugia malayi Major Facilitator Superfamily protein 0.0008 0.0016 0.0016
Echinococcus multilocularis glycine receptor subunit beta 0.0017 0.0337 0.0337
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.2515 0.2515
Brugia malayi Animal haem peroxidase family protein 0.003 0.0791 0.0791
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0017 0.0337 0.0344
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0052 0.1601 0.1601
Brugia malayi Animal haem peroxidase family protein 0.003 0.0791 0.0791
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0014 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0398 0.0398
Echinococcus granulosus neural cadherin 0.001 0.006 0.006
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2487 1
Schistosoma mansoni nAChR subunit 0.0017 0.0337 0.0344
Echinococcus granulosus fibropellin Ia 0.001 0.006 0.006
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.2515 0.2515
Loa Loa (eye worm) blistered cuticle protein 3 0.003 0.0791 0.0791
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Echinococcus multilocularis g-protein coupled receptor 0.0078 0.2515 0.2515
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Trypanosoma brucei glucose transporter, putative 0.0019 0.0383 0.1486
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0048 0.0049
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.2515 0.2515
Echinococcus granulosus solute carrier family 22 0.0008 0.0016 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0087 0.0974
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0017 0.0337 0.0344
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0337 0.0337
Trypanosoma cruzi hexose transporter 0.0019 0.0383 0.1486
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.2515 0.2515
Toxoplasma gondii EGF family domain-containing protein 0.001 0.006 0.0076
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0087 0.0974
Echinococcus granulosus cysteine protease 0.001 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0019 0.0398 0.0406
Brugia malayi Dopamine receptor protein 1 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0078 0.2515 0.2515
Schistosoma mansoni hypothetical protein 0.001 0.006 0.0061
Onchocerca volvulus Cathepsin L homolog 0.002 0.044 0.1749
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2487 1
Schistosoma mansoni notch 0.001 0.006 0.0061
Echinococcus granulosus allatostatin A receptor 0.0078 0.2515 0.2515
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.1372 0.1372
Brugia malayi Sugar transporter family protein 0.0008 0.0016 0.0016
Brugia malayi EGF-like domain containing protein 0.001 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Schistosoma mansoni peroxidasin 0.003 0.0791 0.0807
Brugia malayi Blistered cuticle protein 3 0.003 0.0791 0.0791
Leishmania major glucose transporter, lmgt1 0.0019 0.0383 0.1486
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0795 0.0811
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0017 0.0337 0.0337
Echinococcus multilocularis lamin dm0 0.0033 0.0885 0.0885
Echinococcus granulosus geminin 0.0164 0.5609 0.5609
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0013 0.0195 0.0724
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.1372 0.1399
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0011 0.0122 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0398 0.0398
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0078 0.2515 0.2515
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0791 0.0791
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0078 0.2515 0.2515
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0017 0.0337 0.0337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2487 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0018 0.0375 0.0375
Loa Loa (eye worm) cysteine protease 0.002 0.044 0.044
Echinococcus granulosus intermediate filament protein 0.0033 0.0885 0.0885
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0078 0.2515 0.2515
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Echinococcus multilocularis orexin receptor type 2 0.0078 0.2515 0.2515
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0021 0.0469 0.1833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Onchocerca volvulus Cathepsin F homolog 0.002 0.044 0.1749
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.006 0.1877 0.1877
Brugia malayi putative neuropeptide receptor NPR1 0.0078 0.2515 0.2515
Toxoplasma gondii facilitative glucose transporter GT1 0.006 0.1877 0.3201
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0078 0.2515 0.2515
Brugia malayi Serotonin receptor 0.0078 0.2515 0.2515
Toxoplasma gondii protein kinase, putative 0.017 0.5831 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0052 0.1601 0.1601
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0589 0.2318
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.001 0.006 0.0061
Schistosoma mansoni myelin transcription factor 1 myt1 0.0052 0.1601 0.1633
Onchocerca volvulus 0.002 0.044 0.1749
Echinococcus multilocularis neurogenic locus notch protein 0.001 0.006 0.006
Echinococcus granulosus slit 2 protein 0.001 0.006 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0087 0.0974
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.188 0.188
Onchocerca volvulus 0.0008 0.0016 0.0063
Brugia malayi excitatory GABA receptor EXP-1A 0.0017 0.0337 0.0337
Trichomonas vaginalis glucose transporter, putative 0.0019 0.0383 0.1973
Schistosoma mansoni hypothetical protein 0.0164 0.5609 0.5721
Brugia malayi Melatonin receptor type 1A 0.0078 0.2515 0.2515
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0078 0.2515 0.2515
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0018 0.0361 0.0361
Echinococcus multilocularis serotonin receptor 0.0078 0.2515 0.2515
Echinococcus granulosus GPCR family 2 0.0019 0.0398 0.0398
Schistosoma mansoni alpha-1 adrenergic receptor 0.0078 0.2515 0.2565
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2246 0.9025
Loa Loa (eye worm) LGC-31 protein 0.0017 0.0337 0.0337
Onchocerca volvulus 0.0008 0.0016 0.0063
Brugia malayi Animal haem peroxidase family protein 0.003 0.0791 0.0791
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0008 0.0016 0.0016
Schistosoma mansoni adenoreceptor 0.0078 0.2515 0.2565
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0097 0.3211 0.3595
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0795 0.0811
Brugia malayi hypothetical protein 0.003 0.0791 0.0791
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus multilocularis solute carrier family 22 0.0008 0.0016 0.0016
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.2515 0.2565
Onchocerca volvulus 0.0008 0.0016 0.0063
Leishmania major glucose transporter, lmgt3 0.0019 0.0383 0.1486
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0009 0.0048 0.0049
Trypanosoma brucei glucose transporter 2A 0.0019 0.0383 0.1486
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Brugia malayi Peroxidasin 0.003 0.0791 0.0791
Echinococcus granulosus sex peptide receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0017 0.0337 0.0337
Leishmania major cathepsin L-like protease 0.002 0.044 0.1716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0087 0.0286
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2515 0.2565
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.003 0.0795 0.0795
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0018 0.0375 0.0617
Echinococcus granulosus solute carrier family 22 0.0008 0.0016 0.0016
Schistosoma mansoni sugar transporter 0.0008 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0018 0.0375 0.1451
Schistosoma mansoni biogenic amine receptor 0.0078 0.2515 0.2565
Schistosoma mansoni notch 0.001 0.006 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2515 0.2565
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0589 0.0644
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0018 0.0375 0.0404
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0589 0.0644
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.006 0.1877 0.1877
Onchocerca volvulus 0.0008 0.0016 0.0063
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Schistosoma mansoni lysyl-tRNA synthetase 0.0013 0.0195 0.0199
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Brugia malayi EGF-like domain containing protein 0.001 0.006 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2515 0.2565
Schistosoma mansoni hypothetical protein 0.0078 0.2515 0.2565
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0009 0.0048 0.0048
Onchocerca volvulus 0.0058 0.181 0.7198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0087 0.038
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Leishmania major glucose transporter, lmgt2 0.0019 0.0383 0.1486
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0589 0.2318
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Echinococcus multilocularis solute carrier family 22 0.0008 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.044 0.2278
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0018 0.0375 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0375 0.0382
Leishmania major cysteine peptidase A (CPA) 0.002 0.044 0.1716
Onchocerca volvulus 0.003 0.0791 0.3147
Echinococcus granulosus neuropeptide s receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.003 0.0795 0.0795
Echinococcus multilocularis neuropeptide FF receptor 2 0.0078 0.2515 0.2515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Loa Loa (eye worm) GABA receptor subunit 0.0009 0.0048 0.0048
Echinococcus granulosus lysyl tRNA synthetase 0.0013 0.0195 0.0195
Brugia malayi TAR-binding protein 0.0061 0.1916 0.1916
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.2515 0.2565
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0087 0.0286
Echinococcus granulosus Sugar transporter ERD6 protein 0.0008 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0019 0.0398 0.0406
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0013 0.0195 0.0195
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0018 0.0375 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0199 0.0984
Schistosoma mansoni neuropeptide receptor 0.0078 0.2515 0.2565
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Toxoplasma gondii cathepsin CPL 0.002 0.044 0.0729
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0018 0.0375 0.0375
Plasmodium vivax proline--tRNA ligase, putative 0.0021 0.0469 0.051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.044 0.2278
Schistosoma mansoni nAChR subunit 0.0017 0.0337 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2487 1
Schistosoma mansoni biogenic amine receptor 0.0078 0.2515 0.2565
Onchocerca volvulus 0.0078 0.2515 1
Schistosoma mansoni hypothetical protein 0.0019 0.0398 0.0406
Onchocerca volvulus 0.0078 0.2515 1
Brugia malayi hypothetical protein 0.0078 0.2515 0.2515
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.001 0.006 0.006
Brugia malayi notch-like transmembrane receptor 0.001 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1916 0.1954
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Onchocerca volvulus 0.0033 0.0885 0.3518
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0087 0.0974
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Echinococcus granulosus fmrfamide receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0018 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0048
Schistosoma mansoni sugar transporter 0.0008 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Onchocerca volvulus 0.0078 0.2515 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1916 0.1954
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2487 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0009 0.0048 0.0048
Entamoeba histolytica cysteine protease, putative 0.002 0.044 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Plasmodium falciparum calcium-dependent protein kinase 4 0.0018 0.0375 0.0404
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Echinococcus multilocularis neurogenic locus notch protein 0.001 0.006 0.006
Brugia malayi Papain family cysteine protease containing protein 0.002 0.044 0.044
Leishmania major protein kinase, putative 0.0018 0.0375 0.1451
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0078 0.2515 0.2515
Onchocerca volvulus 0.0008 0.0016 0.0063
Onchocerca volvulus 0.002 0.044 0.1749
Brugia malayi hypothetical protein 0.0078 0.2515 0.2515
Schistosoma mansoni amine GPCR 0.0078 0.2515 0.2565
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.044 0.2278
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0013 0.0195 0.3046
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.2515 0.2515
Schistosoma mansoni glucose transport protein 0.006 0.1877 0.1915
Schistosoma mansoni amine GPCR 0.0078 0.2515 0.2565
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.2515 0.2515
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0013 0.0195 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Schistosoma mansoni slit 0.001 0.006 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0383 0.1973
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.2515 0.2565
Echinococcus multilocularis somatostatin receptor 0.0078 0.2515 0.2515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0087 0.038
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.2515 0.2515
Trypanosoma brucei glucose transporter, putative 0.0019 0.0383 0.1486
Schistosoma mansoni notch 0.001 0.006 0.0061
Schistosoma mansoni hypothetical protein 0.028 0.9804 1
Leishmania major cathepsin L-like protease 0.002 0.044 0.1716
Echinococcus granulosus serotonin receptor 0.0078 0.2515 0.2515
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0012 0.0135 0.0641
Onchocerca volvulus Putative transporter 0.0008 0.0016 0.0063
Echinococcus granulosus peroxidasin 0.003 0.0791 0.0791
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Echinococcus granulosus 7tm_1 domain containing protein 0.0078 0.2515 0.2515
Echinococcus multilocularis GPCR, family 2 0.0019 0.0398 0.0398
Plasmodium falciparum calcium-dependent protein kinase 3 0.0018 0.0375 0.0404
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Schistosoma mansoni growth hormone secretagogue receptor 0.0078 0.2515 0.2565
Brugia malayi EGF-like domain containing protein 0.001 0.006 0.006
Echinococcus granulosus glycine receptor subunit alpha 1 0.0017 0.0337 0.0337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2487 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.044 0.2278
Plasmodium falciparum proline--tRNA ligase 0.0021 0.0469 0.051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2487 1
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.1372 0.1372
Echinococcus granulosus glycine receptor subunit alpha 1 0.0017 0.0337 0.0337
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0017 0.0337 0.0337
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0018 0.0361 0.1855
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0885 0.0885
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0337 0.0337
Schistosoma mansoni hypothetical protein 0.0019 0.0398 0.0406
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0018 0.0375 0.0375
Brugia malayi major facilitator superfamily protein 0.0008 0.0016 0.0016
Brugia malayi Sugar transporter family protein 0.0008 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus granulosus glycine receptor subunit beta 0.0017 0.0337 0.0337
Echinococcus multilocularis g protein coupled receptor 0.0078 0.2515 0.2515
Brugia malayi Cathepsin L-like precursor 0.002 0.044 0.044
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.2515 0.2565
Schistosoma mansoni septate junction protein 0.001 0.006 0.0061
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0791 0.0791
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Schistosoma mansoni hypothetical protein 0.001 0.006 0.0061
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0078 0.2515 0.2515
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0018 0.0375 0.0404
Onchocerca volvulus 0.0008 0.0016 0.0063
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Onchocerca volvulus 0.0078 0.2515 1
Echinococcus granulosus neurogenic locus notch protein 0.001 0.006 0.006
Onchocerca volvulus 0.0009 0.0048 0.0193
Loa Loa (eye worm) hypothetical protein 0.0015 0.0239 0.0239
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0032 0.0863 0.0863
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0589 0.0985
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.003 0.0795 0.0795
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1916 0.1954
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0383 0.1486
Plasmodium vivax calcium-dependent protein kinase, putative 0.0018 0.0375 0.0404
Schistosoma mansoni intermediate filament proteins 0.0033 0.0885 0.0902
Echinococcus granulosus G protein coupled receptor 139 0.0078 0.2515 0.2515
Onchocerca volvulus 0.0033 0.0885 0.3518
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.044 0.0477
Schistosoma mansoni lamin 0.0033 0.0885 0.0902
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0078 0.2515 0.2515
Onchocerca volvulus Dual oxidase homolog 0.003 0.0791 0.3147
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1916 0.1954
Schistosoma mansoni hypothetical protein 0.001 0.006 0.0061
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.2515 0.2565
Echinococcus multilocularis slit 2 protein 0.001 0.006 0.006
Plasmodium falciparum protein kinase 7 0.017 0.5831 0.6542
Echinococcus granulosus protein jagged 2 0.001 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0199 0.0984
Loa Loa (eye worm) hypothetical protein 0.0018 0.0361 0.0361
Onchocerca volvulus 0.0078 0.2515 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0078 0.2515 0.2515
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0013 0.0195 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.2515 0.2565
Plasmodium falciparum protein kinase 6 0.0255 0.8904 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1893 0.7596
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Echinococcus granulosus glycine receptor subunit beta 0.0017 0.0337 0.0337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.044 0.2278
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0087 0.0286
Echinococcus multilocularis G protein coupled receptor 139 0.0078 0.2515 0.2515
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0052 0.1601 0.1601
Onchocerca volvulus 0.0017 0.0337 0.1341
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.1372 0.5455
Trypanosoma brucei THT1 - hexose transporter, putative 0.0019 0.0383 0.1486
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.044 0.0477
Brugia malayi Major Facilitator Superfamily protein 0.0008 0.0016 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2515 0.2565
Echinococcus granulosus synaptic vesicle 2 protein 0.0008 0.0016 0.0016
Onchocerca volvulus 0.002 0.044 0.1749
Loa Loa (eye worm) sugar transporter 0.0008 0.0016 0.0016
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0021 0.0469 0.1833
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0017 0.0337 0.0337
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0017 0.0337 0.0337
Echinococcus multilocularis notch 0.001 0.006 0.006
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.044 0.044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.2515 0.2515
Echinococcus granulosus histone acetyltransferase MYST2 0.0052 0.1601 0.1601
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0017 0.0337 0.0337
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0018 0.0375 0.0375
Onchocerca volvulus 0.001 0.006 0.024
Onchocerca volvulus 0.003 0.0791 0.3147
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0017 0.0337 0.0337
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0017 0.0337 0.0337
Leishmania major glucose transporter/membrane transporter D2, putative 0.0019 0.0383 0.1486
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0018 0.0375 0.0617
Schistosoma mansoni protein kinase 0.0018 0.0375 0.0382
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus multilocularis neurogenic locus protein delta 0.001 0.006 0.006
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0078 0.2515 0.2515
Trichomonas vaginalis glucose transporter, putative 0.0019 0.0383 0.1973
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1916 0.1916
Chlamydia trachomatis lysine--tRNA ligase 0.0013 0.0195 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Brugia malayi Cadherin domain containing protein 0.001 0.006 0.006
Onchocerca volvulus 0.0078 0.2515 1
Schistosoma mansoni amine GPCR 0.0078 0.2515 0.2565
Echinococcus granulosus nAChR subunit 0.0017 0.0337 0.0337
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0017 0.0337 0.0337
Onchocerca volvulus 0.0014 0.0199 0.0791
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0021 0.0469 0.1833
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0018 0.0375 0.0375
Brugia malayi Calcium binding EGF domain containing protein 0.001 0.006 0.006
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0791 0.0791
Leishmania major cathepsin L-like protease 0.0077 0.2487 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0017 0.0337 0.0337
Onchocerca volvulus 0.0078 0.2515 1
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.2515 0.2515
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0017 0.0337 0.0344
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0885 0.0885
Echinococcus granulosus somatostatin receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Schistosoma mansoni opsin-like receptor 0.0078 0.2515 0.2565
Plasmodium vivax lysine--tRNA ligase, putative 0.0013 0.0195 0.0201
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.006 0.1877 0.1877
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0009 0.0048 0.0048
Schistosoma mansoni peroxidasin 0.003 0.0791 0.0807
Loa Loa (eye worm) ctsf protein 0.002 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus granulosus glycine receptor subunit alpha 1 0.0017 0.0337 0.0337
Schistosoma mansoni hypothetical protein 0.001 0.006 0.0061
Giardia lamblia High cysteine protein 0.001 0.006 0.1285
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0078 0.2515 0.2515
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0048
Echinococcus granulosus hypothetical protein 0.0078 0.2515 0.2515
Brugia malayi Animal haem peroxidase family protein 0.003 0.0791 0.0791
Entamoeba histolytica protein kinase, putative 0.0018 0.0375 0.8332
Echinococcus multilocularis neuropeptide receptor A26 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Brugia malayi AKH receptor 0.0078 0.2515 0.2515
Onchocerca volvulus 0.0008 0.0016 0.0063
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0018 0.0361 0.0361
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.044 0.044
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Echinococcus granulosus orexin receptor type 2 0.0078 0.2515 0.2515
Onchocerca volvulus 0.0017 0.0337 0.1341
Echinococcus granulosus alpha 1A adrenergic receptor 0.0078 0.2515 0.2515
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0018 0.0361 0.0368
Echinococcus multilocularis serotonin receptor 0.0078 0.2515 0.2515
Echinococcus granulosus neuropeptide receptor 0.0078 0.2515 0.2515
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.003 0.0795 0.0795
Schistosoma mansoni hypothetical protein 0.0164 0.5609 0.5721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2487 1
Trypanosoma cruzi cysteine protease, putative 0.001 0.0087 0.0286
Echinococcus multilocularis neuropeptide receptor 0.0078 0.2515 0.2515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Echinococcus multilocularis survival motor neuron protein 1 0.0286 1 1
Onchocerca volvulus Peroxidase homolog 0.003 0.0791 0.3147
Echinococcus granulosus notch 0.001 0.006 0.006
Plasmodium falciparum calcium-dependent protein kinase 5 0.0018 0.0375 0.0404
Echinococcus multilocularis nAChR subunit 0.0009 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Schistosoma mansoni neuropeptide receptor 0.0078 0.2515 0.2565
Brugia malayi EGF-like domain containing protein 0.001 0.006 0.006
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.044 0.044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0009 0.0048 0.0049
Echinococcus granulosus solute carrier family 22 0.0008 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Brugia malayi mbt repeat family protein 0.0046 0.1372 0.1372
Echinococcus multilocularis g protein coupled receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) ACC-1 protein 0.0017 0.0337 0.0337
Brugia malayi sulfakinin receptor protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0041 0.1194 0.1194
Onchocerca volvulus 0.002 0.044 0.1749
Brugia malayi hypothetical protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Brugia malayi EGF-like domain containing protein 0.001 0.006 0.006
Echinococcus granulosus cathepsin l1 0.0014 0.0199 0.0199
Onchocerca volvulus 0.0008 0.0016 0.0063
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.044 0.044
Onchocerca volvulus 0.0017 0.0337 0.1341
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.044 0.2278
Onchocerca volvulus 0.0078 0.2515 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0885 0.0885
Echinococcus granulosus protein jagged 1 0.001 0.006 0.006
Brugia malayi follicle stimulating hormone receptor 0.0078 0.2515 0.2515
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0021 0.0469 0.1833
Entamoeba histolytica cysteine proteinase 2 0.001 0.0087 0.0974
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.006 0.1877 0.1877
Onchocerca volvulus 0.0078 0.2515 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0018 0.0375 0.0404
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0097 0.3211 0.5495
Loa Loa (eye worm) hypothetical protein 0.006 0.188 0.188
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0078 0.2515 0.2515
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0383 0.1486
Plasmodium falciparum lysine--tRNA ligase 0.0013 0.0195 0.0201
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0078 0.2515 0.2515
Brugia malayi Cathepsin L-like precursor 0.002 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0014 0.0199 0.0199
Giardia lamblia Lysyl-tRNA synthetase 0.0013 0.0195 0.5182
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Echinococcus granulosus solute carrier family 22 0.0008 0.0016 0.0016
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.2515 0.2515
Echinococcus multilocularis nAChR subunit 0.0017 0.0337 0.0337
Onchocerca volvulus 0.0017 0.0337 0.1341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2487 1
Brugia malayi mbt repeat family protein 0.0046 0.1372 0.1372
Brugia malayi Tachykinin-like peptides receptor 99D 0.0078 0.2515 0.2515
Brugia malayi G-protein coupled receptor 0.0078 0.2515 0.2515
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0078 0.2515 0.2565
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.006 0.1877 0.1877
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0087 0.0087
Plasmodium falciparum hexose transporter 0.006 0.1877 0.2094
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0017 0.0337 0.0337
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1916 0.1916
Loa Loa (eye worm) hypothetical protein 0.0018 0.0361 0.0361
Schistosoma mansoni glucose transport protein 0.006 0.1877 0.1915
Brugia malayi Delta serrate ligand family protein 0.001 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Echinococcus multilocularis G-protein coupled receptor, putative 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Brugia malayi neuropeptide F receptor 0.0078 0.2515 0.2515
Brugia malayi G-protein coupled receptor 0.0078 0.2515 0.2515
Brugia malayi Cation transporter family protein 0.0017 0.0337 0.0337
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0087 0.0286
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0017 0.0337 0.0337
Schistosoma mansoni notch 0.001 0.006 0.0061
Echinococcus multilocularis protein jagged 2 0.001 0.006 0.006
Echinococcus multilocularis neuropeptide s receptor 0.0078 0.2515 0.2515
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0278 0.0278
Brugia malayi Cathepsin L-like precursor 0.002 0.044 0.044
Brugia malayi hypothetical protein 0.0008 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.1372 0.1372
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.1372 0.1399
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.6254 0.6254
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0018 0.0361 1
Onchocerca volvulus 0.001 0.006 0.024
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0087 0.0088
Schistosoma mansoni nAChR subunit 0.0017 0.0337 0.0344
Loa Loa (eye worm) hypothetical protein 0.0015 0.0256 0.0256
Onchocerca volvulus Peroxidasin homolog 0.003 0.0791 0.3147
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.2515 0.2565
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0021 0.0469 0.0779
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.006 0.1877 0.1877
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Schistosoma mansoni amine GPCR 0.0078 0.2515 0.2565
Onchocerca volvulus 0.002 0.044 0.1749
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0078 0.2515 0.2565
Schistosoma mansoni protein kinase 0.0018 0.0375 0.0382
Brugia malayi G protein-coupled receptor F59B2.13 0.0078 0.2515 0.2515
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0021 0.0469 0.1833
Schistosoma mansoni biogenic amine receptor 0.0078 0.2515 0.2565
Schistosoma mansoni hypothetical protein 0.0041 0.1194 0.1218
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0048
Onchocerca volvulus 0.0008 0.0016 0.0063
Schistosoma mansoni histamine h1 receptor 0.0078 0.2515 0.2565
Loa Loa (eye worm) major facilitator superfamily transporter 0.0008 0.0016 0.0016
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.1372 0.1399
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0018 0.0375 0.0375
Schistosoma mansoni neuropeptide receptor 0.0078 0.2515 0.2565
Loa Loa (eye worm) melatonin receptor type 1A 0.0078 0.2515 0.2515
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.006 0.1877 0.1877
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0014 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.044 0.2278
Schistosoma mansoni neuropeptide receptor 0.0078 0.2515 0.2565
Brugia malayi Dopamine receptor protein 2 0.0078 0.2515 0.2515
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0017 0.0337 0.0337
Echinococcus multilocularis calcium dependent protein kinase 0.0017 0.0334 0.0334
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0018 0.0361 0.7989
Schistosoma mansoni nAChR subunit 0.0017 0.0337 0.0344
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0078 0.2515 0.2565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0087 0.0286
Brugia malayi Sugar transporter family protein 0.006 0.1877 0.1877
Schistosoma mansoni laminin gamma-3 chain 0.001 0.006 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0383 0.1973
Schistosoma mansoni sugar transporter 0.0008 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Echinococcus granulosus g protein coupled receptor 0.0078 0.2515 0.2515
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0013 0.0195 0.0961
Onchocerca volvulus 0.0008 0.0016 0.0063
Brugia malayi larval opioid receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.2515 0.2515
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0046 0.1372 0.1372
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0087 0.0088
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.2515 0.2515
Echinococcus multilocularis cysteine protease 0.002 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0286 1 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.6254 0.6254
Brugia malayi cathepsin L-like precursor 0.0014 0.0199 0.0199
Brugia malayi hypothetical protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0052 0.1601 0.1601
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Onchocerca volvulus 0.0078 0.2515 1
Brugia malayi Calcium binding EGF domain containing protein 0.001 0.006 0.006
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0087 0.008
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Onchocerca volvulus 0.0008 0.0016 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.003 0.0795 0.0795
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0398 0.0398
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.044 0.044
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.2515 0.2515
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0017 0.0337 0.0337
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0078 0.2515 0.2565
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Echinococcus granulosus neurogenic locus notch protein 4 0.001 0.006 0.006
Echinococcus granulosus neurogenic locus protein delta 0.001 0.006 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.044 0.1716
Brugia malayi G protein-coupled receptor 0.0078 0.2515 0.2515
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.044 0.0449
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.044 0.2278
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2515 0.2565
Onchocerca volvulus 0.0078 0.2515 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.2515 0.2515
Schistosoma mansoni hypothetical protein 0.001 0.006 0.0061
Echinococcus granulosus 7TM GPCR rhodopsin 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.044 0.044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.044 0.2278
Loa Loa (eye worm) hypothetical protein 0.0016 0.0278 0.0278
Trypanosoma brucei glucose transporter, putative 0.0019 0.0383 0.1486
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus multilocularis neurogenic locus protein delta 0.001 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.044 0.0449
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Onchocerca volvulus 0.001 0.006 0.024
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Brugia malayi RNA binding protein 0.0061 0.1916 0.1916
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0087 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2515 0.2565
Loa Loa (eye worm) fibroinase 0.002 0.044 0.044
Brugia malayi EGF-like domain containing protein 0.001 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.044 0.0477
Trypanosoma brucei glucose transporter, putative 0.0019 0.0383 0.1486
Schistosoma mansoni lamin 0.0033 0.0885 0.0902
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0008 0.0016 0.0016
Plasmodium falciparum calcium-dependent protein kinase 2 0.0018 0.0375 0.0404
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0087 0.0087
Echinococcus granulosus delta-like protein 1 0.001 0.006 0.006
Onchocerca volvulus 0.0008 0.0016 0.0063
Loa Loa (eye worm) hypothetical protein 0.0015 0.0256 0.0256
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0199 0.0199
Brugia malayi hypothetical protein 0.0078 0.2515 0.2515
Echinococcus granulosus protein jagged 1 0.001 0.006 0.006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0017 0.0337 0.0337
Schistosoma mansoni hypothetical protein 0.006 0.1877 0.1915
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0589 0.0644
Brugia malayi Calcium binding EGF domain containing protein 0.001 0.006 0.006
Loa Loa (eye worm) sugar transporter 0.006 0.1877 0.1877
Brugia malayi Cation transporter family protein 0.0017 0.0337 0.0337
Echinococcus granulosus peptide allatostatin:somatostatin 0.0078 0.2515 0.2515
Brugia malayi hypothetical protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.188 0.188
Loa Loa (eye worm) TYRA-2 protein 0.0078 0.2515 0.2515
Brugia malayi neuropeptide F receptor 0.0078 0.2515 0.2515
Echinococcus granulosus g-protein coupled receptor 0.0078 0.2515 0.2515
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Onchocerca volvulus 0.0078 0.2515 1
Brugia malayi Cathepsin L-like precursor 0.002 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Giardia lamblia Prolyl-tRNA synthetase 0.0018 0.0361 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0078 0.2515 0.2515
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0383 0.1973
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.044 0.2278
Echinococcus granulosus neuropeptide receptor A26 0.0078 0.2515 0.2515
Plasmodium vivax vivapain-2 0.002 0.044 0.0477
Schistosoma mansoni hypothetical protein 0.0011 0.0105 0.0107
Brugia malayi Animal haem peroxidase family protein 0.003 0.0791 0.0791
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1916 0.1916
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0087 0.0974
Schistosoma mansoni hypothetical protein 0.001 0.006 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.044 0.2278
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Plasmodium falciparum mitogen-activated protein kinase 2 0.0097 0.3211 0.3595
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0018 0.0375 0.0375
Echinococcus granulosus calcium dependent protein kinase 0.0017 0.0334 0.0334
Brugia malayi hypothetical protein 0.0078 0.2515 0.2515
Echinococcus granulosus g protein coupled receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Onchocerca volvulus 0.0078 0.2515 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.181 0.1846
Brugia malayi hypothetical protein 0.0078 0.2515 0.2515
Echinococcus multilocularis fmrfamide receptor 0.0078 0.2515 0.2515
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.2515 0.2565
Onchocerca volvulus Neurogenic locus notch homolog 0.001 0.006 0.024
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0105 0.0105
Schistosoma mansoni nAChR subunit 0.0017 0.0337 0.0344
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0078 0.2515 0.2565
Schistosoma mansoni hypothetical protein 0.0058 0.181 0.1846
Loa Loa (eye worm) notch protein 0.001 0.006 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2515 0.2565
Plasmodium vivax vivapain-2 0.002 0.044 0.0477
Onchocerca volvulus 0.0009 0.0048 0.0193
Plasmodium vivax hexose transporter 0.006 0.1877 0.2094
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.044 0.044
Echinococcus multilocularis synaptic vesicle 2 protein 0.0008 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0018 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Leishmania major cathepsin L-like protease 0.002 0.044 0.1716
Onchocerca volvulus Putative cubilin 0.001 0.006 0.024
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0017 0.0337 0.0337
Leishmania major cathepsin L-like protease 0.0077 0.2487 1
Onchocerca volvulus 0.0008 0.0016 0.0063
Onchocerca volvulus 0.0008 0.0016 0.0063
Schistosoma mansoni hypothetical protein 0.001 0.006 0.0061
Brugia malayi hypothetical protein 0.0078 0.2515 0.2515
Echinococcus multilocularis sex peptide receptor 0.0078 0.2515 0.2515
Echinococcus multilocularis g protein coupled receptor 0.0078 0.2515 0.2515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Onchocerca volvulus Putative nachr subunit 0.0017 0.0337 0.1341
Plasmodium vivax vivapain-1 0.001 0.0087 0.008
Onchocerca volvulus 0.001 0.006 0.024
Echinococcus granulosus neurogenic locus notch protein 0.001 0.006 0.006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0017 0.0337 0.0337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Echinococcus multilocularis neuropeptide receptor 0.0078 0.2515 0.2515
Onchocerca volvulus 0.002 0.044 0.1749
Leishmania major cathepsin L-like protease 0.0077 0.2487 1
Brugia malayi ORL1-like opioid receptor 0.0078 0.2515 0.2515
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0017 0.0337 0.0337
Trypanosoma brucei glucose transporter, putative 0.0019 0.0383 0.1486
Brugia malayi Cathepsin L-like precursor 0.002 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.2515 0.2515
Echinococcus granulosus General substrate transporter 0.0052 0.1573 0.1573
Onchocerca volvulus 0.0078 0.2515 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Echinococcus multilocularis cysteine protease 0.002 0.044 0.044
Plasmodium vivax unspecified product 0.001 0.0087 0.008
Brugia malayi GCC2 and GCC3 family protein 0.001 0.006 0.006
Echinococcus multilocularis dro:myosuppressin receptor 0.0078 0.2515 0.2515
Echinococcus multilocularis musashi 0.0033 0.0885 0.0885
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Schistosoma mansoni nAChR subunit 0.0017 0.0337 0.0344
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus multilocularis General substrate transporter 0.0052 0.1573 0.1573
Brugia malayi Cam kinase protein 1 0.0018 0.0375 0.0375
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0018 0.0375 0.0375
Echinococcus multilocularis solute carrier family 22 0.0008 0.0016 0.0016
Brugia malayi Cation transporter family protein 0.0017 0.0337 0.0337
Entamoeba histolytica cysteine proteinase, putative 0.002 0.044 1
Onchocerca volvulus 0.002 0.044 0.1749
Echinococcus multilocularis glycine receptor subunit beta 0.0017 0.0337 0.0337
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0017 0.0337 0.0337
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.2515 0.2515
Loa Loa (eye worm) MBCTL1 0.0052 0.1601 0.1601
Schistosoma mansoni neuropeptide f receptor 76f 0.0078 0.2515 0.2565
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2487 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0048
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.2515 0.2565
Schistosoma mansoni lysyl-tRNA synthetase 0.0013 0.0195 0.0199
Brugia malayi Cathepsin L-like precursor 0.002 0.044 0.044
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1916 0.1916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Brugia malayi major facilitator superfamily protein 0.0008 0.0016 0.0016
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.181 0.181
Schistosoma mansoni notch 0.001 0.006 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Brugia malayi intermediate filament protein 0.0033 0.0885 0.0885
Trypanosoma cruzi hexose transporter, putative 0.001 0.0078 0.0253
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2487 1
Brugia malayi Cadherin domain containing protein 0.001 0.006 0.006
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0383 0.1973
Entamoeba histolytica protein kinase, putative 0.0018 0.0375 0.8332
Leishmania major lysyl-tRNA synthetase, putative 0.0013 0.0195 0.0724
Onchocerca volvulus 0.003 0.0791 0.3147
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Onchocerca volvulus Neurogenic locus notch protein homolog 0.001 0.006 0.024
Brugia malayi EGF-like domain containing protein 0.001 0.006 0.006
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0383 0.1973
Echinococcus multilocularis fibropellin Ia 0.001 0.006 0.006
Onchocerca volvulus 0.0078 0.2515 1
Echinococcus multilocularis neural cadherin 0.001 0.006 0.006
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.2515 0.2515
Brugia malayi Major Facilitator Superfamily protein 0.0008 0.0016 0.0016
Loa Loa (eye worm) major facilitator superfamily transporter 0.0008 0.0016 0.0016
Onchocerca volvulus Peroxidase homolog 0.003 0.0791 0.3147
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0048
Echinococcus multilocularis lysyl tRNA synthetase 0.0013 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Schistosoma mansoni myosin xvIII 0.0078 0.2515 0.2565
Schistosoma mansoni opsin-like receptor 0.0078 0.2515 0.2565
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.034 0.034
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0018 0.0361 0.0361
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0199 0.3846
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0017 0.0337 0.0337
Schistosoma mansoni amine GPCR 0.0078 0.2515 0.2565
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0398 0.0398
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0078 0.2515 0.2515
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0018 0.0361 0.0361
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0078 0.2515 0.2515
Plasmodium vivax vivapain-3 0.001 0.0087 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0078 0.2515 0.2565
Leishmania major cathepsin L-like protease 0.002 0.044 0.1716
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.006 0.1877 0.1877
Echinococcus granulosus g protein coupled receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0017 0.0337 0.0337
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0087 0.0286
Onchocerca volvulus 0.001 0.006 0.024
Brugia malayi hypothetical protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0017 0.0337 0.0337
Echinococcus multilocularis protein jagged 1 0.001 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0048
Echinococcus granulosus survival motor neuron protein 1 0.0286 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0048
Echinococcus granulosus dro:myosuppressin receptor 0.0078 0.2515 0.2515
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0589 0.2318
Brugia malayi putative neuropeptide receptor 0.0078 0.2515 0.2515
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.034 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0383 0.1486
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.002 0.044 0.044
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Schistosoma mansoni nAChR subunit 0.0017 0.0337 0.0344
Trypanosoma brucei THT1 - hexose transporter, putative 0.0019 0.0383 0.1486
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.2487 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.2515 0.2515
Brugia malayi Cathepsin L-like precursor 0.0014 0.0199 0.0199
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.1372 0.1372
Loa Loa (eye worm) ACC-1 protein 0.0017 0.0337 0.0337
Brugia malayi Muscle positioning protein 4 0.001 0.006 0.006
Echinococcus granulosus cathepsin l1 0.002 0.044 0.044
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0017 0.0337 0.0337
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0017 0.0337 0.0337
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0017 0.0337 0.0337
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0199 0.0203
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.006 0.1877 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0398 0.0398
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0087 0.0088
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0078 0.2515 0.2565
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Schistosoma mansoni protein kinase 0.0018 0.0375 0.0382
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Leishmania major cathepsin L-like protease 0.002 0.044 0.1716
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0017 0.0337 0.0344
Trichomonas vaginalis CAMK family protein kinase 0.0018 0.0375 0.1927
Schistosoma mansoni notch 0.001 0.006 0.0061
Schistosoma mansoni sugar transporter 0.0008 0.0016 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2515 0.2565
Brugia malayi lysyl-tRNA synthetase 0.0013 0.0195 0.0195
Echinococcus multilocularis allatostatin A receptor 0.0078 0.2515 0.2515
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0078 0.2515 0.2515
Onchocerca volvulus Cathepsin L homolog 0.002 0.044 0.1749
Brugia malayi Dopamine receptor 0.0078 0.2515 0.2515
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0105 0.0105
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Schistosoma mansoni hypothetical protein 0.0078 0.2515 0.2565
Brugia malayi Serotonin receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0018 0.0361 0.0368
Echinococcus granulosus nAChR subunit 0.0009 0.0048 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2487 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2515 0.2565
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0078 0.2515 0.2515
Onchocerca volvulus 0.0046 0.1372 0.5455
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0337 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Echinococcus granulosus lamin 0.0033 0.0885 0.0885
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.1372 0.1372
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Schistosoma mansoni glucose transporter 0.0008 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.2515 0.2515
Echinococcus multilocularis neurogenic locus notch protein 4 0.001 0.006 0.006
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1916 0.1954
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Brugia malayi Cathepsin L-like precursor 0.0014 0.0199 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2487 1
Trypanosoma brucei glucose transporter, putative 0.0019 0.0383 0.1486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2515 0.2515
Onchocerca volvulus 0.0008 0.0016 0.0063
Trypanosoma brucei glucose transporter 1E 0.0019 0.0383 0.1486
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0011 0.0122 1
Leishmania major hypothetical protein, conserved 0.0024 0.0589 0.2318
Brugia malayi hypothetical protein 0.0024 0.0589 0.0589
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0078 0.2515 0.2565
Trypanosoma brucei glucose transporter, putative 0.0019 0.0383 0.1486
Onchocerca volvulus Neuropeptide F receptor homolog 0.0078 0.2515 1
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0791 0.0791
Echinococcus granulosus tar DNA binding protein 0.0061 0.1916 0.1916
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.003 0.0795 0.0795
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0337 0.0337
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0078 0.2515 0.2565
Schistosoma mansoni opsin-like receptor 0.0078 0.2515 0.2565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Echinococcus multilocularis solute carrier family 22 0.0008 0.0016 0.0016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0009 0.0048 0.0048
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0017 0.0337 0.0337
Onchocerca volvulus Peroxidasin homolog 0.003 0.0791 0.3147
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Onchocerca volvulus 0.0017 0.0337 0.1341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Onchocerca volvulus 0.0078 0.2515 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Echinococcus granulosus neuropeptide receptor 0.0078 0.2515 0.2515
Echinococcus granulosus protein jagged 2 0.001 0.006 0.006
Onchocerca volvulus Chorion peroxidase homolog 0.003 0.0791 0.3147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Onchocerca volvulus 0.0017 0.0337 0.1341
Schistosoma mansoni cell polarity protein 0.001 0.006 0.0061
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0018 0.0375 0.0617
Onchocerca volvulus 0.0008 0.0016 0.0063
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0398 0.0398
Entamoeba histolytica hypothetical protein 0.0013 0.0195 0.3738
Toxoplasma gondii lysine-tRNA ligase 0.0013 0.0195 0.0308
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0078 0.2515 0.2565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.044 0.2278
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Echinococcus multilocularis geminin 0.0164 0.5609 0.5609
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Echinococcus granulosus lamin dm0 0.0033 0.0885 0.0885
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0008 0.0016 0.5
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0017 0.0337 0.0344
Brugia malayi hypothetical protein 0.0016 0.0278 0.0278
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0078 0.2515 0.2515
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0078 0.2515 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0019 0.0383 0.1486
Brugia malayi hypothetical protein 0.0008 0.0016 0.0016
Plasmodium vivax CDK-related protein kinase 6, putative 0.0255 0.8904 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0017 0.0337 0.0344
Brugia malayi RE15519p 0.0078 0.2515 0.2515
Entamoeba histolytica cysteine proteinase, putative 0.002 0.044 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0885 0.0885
Brugia malayi hypothetical protein 0.0008 0.0016 0.0016
Echinococcus multilocularis lamin 0.0033 0.0885 0.0885
Entamoeba histolytica cysteine protease, putative 0.001 0.0087 0.0974
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0052 0.1601 0.1601
Loa Loa (eye worm) Notch2 0.001 0.006 0.006
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0013 0.0195 0.0724
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0795 0.0811
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.2515 0.2515
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0017 0.0337 0.0337
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.2515 0.2515
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0017 0.0337 0.0337
Schistosoma mansoni glucose transport protein 0.006 0.1877 0.1915
Echinococcus multilocularis protein jagged 1 0.001 0.006 0.006
Trypanosoma brucei glucose transporter, putative 0.0019 0.0383 0.1486
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.188 0.188
Loa Loa (eye worm) RNA binding protein 0.0061 0.1916 0.1916
Echinococcus multilocularis fat cadherin tumor suppressor 0.001 0.006 0.006
Onchocerca volvulus 0.0078 0.2515 1
Echinococcus granulosus cathepsin L 0.001 0.0087 0.0087
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0018 0.0375 0.0404
Echinococcus multilocularis peroxidasin 0.003 0.0791 0.0791
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0078 0.2515 0.2515
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.003 0.0791 0.0791
Loa Loa (eye worm) hypothetical protein 0.0078 0.2515 0.2515
Loa Loa (eye worm) hypothetical protein 0.0017 0.0337 0.0337
Onchocerca volvulus Slit protein homolog 0.001 0.006 0.024
Echinococcus multilocularis cathepsin L 0.001 0.0087 0.0087
Brugia malayi GnHR receptor homolog 0.0078 0.2515 0.2515

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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