Detailed information for compound 1356342
Basic information
Technical information
- Name: Unnamed compound
- MW: 329.827 | Formula: C17H20ClN5
-
H donors: 2
H acceptors: 2
LogP: 3.29
Rotable bonds: 4
Rule of 5 violations (Lipinski): 1 - SMILES: CCN1CCCC1CNc1[nH]cnc2c1nc1c2cc(cc1)Cl
- InChi: 1S/C17H20ClN5/c1-2-23-7-3-4-12(23)9-19-17-16-15(20-10-21-17)13-8-11(18)5-6-14(13)22-16/h5-6,8,10,12,19H,2-4,7,9H2,1H3,(H,20,21)
- InChiKey: TZCZVSAUNQBVFA-UHFFFAOYSA-N
Network
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Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Plasmodium falciparum | calcium-dependent protein kinase 1 | Starlite/ChEMBL | No references |
| Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
| Homo sapiens | arachidonate 15-lipoxygenase, type B | Starlite/ChEMBL | No references |
| Homo sapiens | solute carrier family 2 (facilitated glucose transporter), member 1 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | hexose transporter | Starlite/ChEMBL | No references |
| Plasmodium falciparum (isolate 3D7) | Calcium-dependent protein kinase 4 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | lysine--tRNA ligase | Starlite/ChEMBL | No references |
| Plasmodium falciparum (isolate 3D7) | Proline--tRNA ligase | Starlite/ChEMBL | No references |
| Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
| Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
| Leishmania mexicana | glucose transporter, lmgt2 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | mitogen-activated protein kinase 2 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | protein kinase 6 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | protein kinase 7 | Starlite/ChEMBL | No references |
| Trypanosoma cruzi | cysteine peptidase, putative | Starlite/ChEMBL | No references |
Predicted pathogen targets for this compound
By orthology
By sequence similarity to non orthologous known druggable targets
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Trypanosoma cruzi | major cysteine proteinase, putative | 0.0061 | 0.09 | 0.7219 |
| Giardia lamblia | Lysyl-tRNA synthetase | 0.0028 | 0.028 | 0.5182 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.1216 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.033 | 0.1462 |
| Echinococcus granulosus | lysyl tRNA synthetase | 0.0028 | 0.028 | 0.1135 |
| Trypanosoma brucei | glucose transporter 1E | 0.0039 | 0.049 | 0.3608 |
| Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0114 | 0.192 | 1 |
| Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0166 | 0.0672 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0.0106 | 0.0225 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Echinococcus granulosus | BC026374 protein S09 family | 0.0022 | 0.0166 | 0.0672 |
| Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0197 | 0.0797 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0081 | 0.0374 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.2158 | 0.8741 |
| Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0197 | 0.0486 |
| Schistosoma mansoni | acetylcholinesterase | 0.0022 | 0.0166 | 0.0672 |
| Trichomonas vaginalis | glucose transporter, putative | 0.0039 | 0.049 | 0.2273 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Loa Loa (eye worm) | cysteine protease | 0.002 | 0.0128 | 0.0567 |
| Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0106 | 0.043 |
| Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0128 | 0.3411 |
| Loa Loa (eye worm) | CAMK/CAMK2 protein kinase | 0.0039 | 0.0481 | 0.213 |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0128 | 0.0567 |
| Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0166 | 0.0735 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0081 | 0.0327 |
| Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0033 | 0.0375 | 0.152 |
| Onchocerca volvulus | 0.0022 | 0.0166 | 0.4424 | |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0022 | 0.0166 | 0.0358 |
| Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0.0166 | 0.0464 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.1216 | 1 |
| Echinococcus multilocularis | neuroligin | 0.0022 | 0.0166 | 0.0358 |
| Schistosoma mansoni | DNA topoisomerase II | 0.0033 | 0.0375 | 0.152 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.1216 | 1 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Onchocerca volvulus | 0.0024 | 0.0197 | 0.5244 | |
| Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0128 | 0.0567 |
| Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0024 | 0.0107 |
| Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0027 | 0.025 | 0.1495 |
| Brugia malayi | Sugar transporter family protein | 0.0018 | 0.0081 | 0.0357 |
| Onchocerca volvulus | 0.0022 | 0.0166 | 0.4424 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.2158 | 0.8699 |
| Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0106 | 0.0107 |
| Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0114 | 0.192 | 1 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.1216 | 1 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Onchocerca volvulus | 0.002 | 0.0128 | 0.3411 | |
| Trypanosoma cruzi | cruzipain precursor, putative | 0.0077 | 0.1216 | 1 |
| Entamoeba histolytica | DNA topoisomerase II, putative | 0.0033 | 0.0375 | 0.7804 |
| Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0027 | 0.025 | 0.1495 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Schistosoma mansoni | loxhd1 | 0.0024 | 0.0197 | 0.0797 |
| Chlamydia trachomatis | DNA gyrase subunit B | 0.006 | 0.0886 | 0.3695 |
| Brugia malayi | Cam kinase protein 1 | 0.0039 | 0.0481 | 0.213 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0481 | 0.1676 |
| Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0022 | 0.0166 | 0.0358 |
| Entamoeba histolytica | cysteine protease, putative | 0.002 | 0.0128 | 0.2662 |
| Mycobacterium leprae | Probable prolyl tRNA synthetase ProS | 0.0038 | 0.0466 | 0.4598 |
| Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0038 | 0.0466 | 0.2064 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Brugia malayi | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Plasmodium falciparum | DNA topoisomerase 2 | 0.0033 | 0.0375 | 0.0297 |
| Entamoeba histolytica | protein kinase, putative | 0.0039 | 0.0481 | 1 |
| Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0106 | 0.0225 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.049 | 0.2273 |
| Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Trypanosoma brucei | glucose transporter 2A | 0.0039 | 0.049 | 0.3608 |
| Leishmania major | glucose transporter, lmgt2 | 0.0039 | 0.049 | 0.3608 |
| Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0016 | 0.0038 | 0.017 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.0081 | 0.0357 |
| Onchocerca volvulus | 0.002 | 0.0128 | 0.3411 | |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0081 | 0.0374 |
| Plasmodium falciparum | calcium-dependent protein kinase 1 | 0.0039 | 0.0481 | 0.0404 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Plasmodium falciparum | LCCL domain-containing protein | 0.0024 | 0.0197 | 0.0117 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK2A | 0.0039 | 0.0481 | 0.0617 |
| Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0166 | 0.0672 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0081 | 0.0327 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0106 | 0.0107 |
| Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0106 | 0.0107 |
| Mycobacterium leprae | Possible lysyl-tRNA synthetase 2 LysX | 0.0028 | 0.028 | 0.1401 |
| Onchocerca volvulus | 0.0024 | 0.0197 | 0.5244 | |
| Onchocerca volvulus | 0.0022 | 0.0166 | 0.4424 | |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Plasmodium falciparum | calcium-dependent protein kinase 2 | 0.0039 | 0.0481 | 0.0404 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0039 | 0.0481 | 0.213 |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0128 | 0.0567 |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0128 | 0.0567 |
| Leishmania major | cathepsin L-like protease | 0.0077 | 0.1216 | 1 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.0081 | 0.0357 |
| Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0.0166 | 0.0464 |
| Mycobacterium ulcerans | DNA gyrase subunit A | 0.0114 | 0.192 | 1 |
| Echinococcus granulosus | calcium dependent protein kinase | 0.0036 | 0.0435 | 0.1763 |
| Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.0166 | 0.0735 |
| Echinococcus granulosus | acetylcholinesterase | 0.0131 | 0.2258 | 0.9145 |
| Echinococcus granulosus | synaptic vesicle 2 protein | 0.0018 | 0.0081 | 0.0327 |
| Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.006 | 0.0886 | 0.438 |
| Toxoplasma gondii | prolyl-tRNA synthetase (ProRS) | 0.0044 | 0.0586 | 0.0779 |
| Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0466 | 0.2064 |
| Mycobacterium tuberculosis | Lysyl-tRNA synthetase 2 LysX | 0.0024 | 0.0199 | 0.0643 |
| Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0128 | 0.0198 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK2B | 0.0039 | 0.0481 | 0.0617 |
| Onchocerca volvulus | 0.002 | 0.0128 | 0.3411 | |
| Entamoeba histolytica | hypothetical protein | 0.0028 | 0.028 | 0.5828 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0481 | 0.1676 |
| Trypanosoma cruzi | hexose transporter | 0.0039 | 0.049 | 0.3608 |
| Plasmodium vivax | multidomain scavenger receptor, putative | 0.0024 | 0.0197 | 0.0117 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0081 | 0.0374 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0033 | 0.0375 | 1 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0033 | 0.0375 | 0.1662 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Mycobacterium ulcerans | carboxylesterase, LipT | 0.0022 | 0.0166 | 0.0464 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Echinococcus multilocularis | para nitrobenzyl esterase | 0.0022 | 0.0166 | 0.0358 |
| Loa Loa (eye worm) | doublecortin family protein | 0.0024 | 0.0197 | 0.0872 |
| Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0106 | 0.0428 |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.2158 | 0.8699 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Leishmania major | protein kinase, putative | 0.0039 | 0.0481 | 0.3525 |
| Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0166 | 0.0672 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Echinococcus multilocularis | carboxylesterase 5A | 0.0131 | 0.2258 | 0.9116 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.049 | 0.2273 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0081 | 0.0327 |
| Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.1216 | 1 |
| Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.0128 | 0.2662 |
| Echinococcus multilocularis | lysyl tRNA synthetase | 0.0028 | 0.028 | 0.0836 |
| Trypanosoma cruzi | lysyl-tRNA synthetase, putative | 0.0028 | 0.028 | 0.1758 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0081 | 0.0374 |
| Plasmodium falciparum | DNA gyrase subunit A | 0.0114 | 0.192 | 0.1854 |
| Brugia malayi | Papain family cysteine protease containing protein | 0.002 | 0.0128 | 0.0567 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.1216 | 1 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Chlamydia trachomatis | DNA gyrase subunit A | 0.0114 | 0.192 | 1 |
| Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.2469 | 1 |
| Plasmodium falciparum | protein kinase 7 | 0.0357 | 0.657 | 0.6542 |
| Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0128 | 0.0519 |
| Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0166 | 0.0735 |
| Leishmania major | cathepsin L-like protease | 0.002 | 0.0128 | 0.0417 |
| Brugia malayi | Sugar transporter family protein | 0.0126 | 0.2158 | 0.9559 |
| Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0022 | 0.0166 | 0.0769 |
| Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0028 | 0.028 | 0.1085 |
| Echinococcus multilocularis | cysteine protease | 0.002 | 0.0128 | 0.0198 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0081 | 0.0327 |
| Schistosoma mansoni | lipoxygenase | 0.0142 | 0.2469 | 1 |
| Loa Loa (eye worm) | carboxylesterase | 0.0131 | 0.2258 | 1 |
| Plasmodium vivax | DNA gyrase subunit A, putative | 0.0114 | 0.192 | 0.1854 |
| Leishmania major | cathepsin L-like protease | 0.0077 | 0.1216 | 1 |
| Onchocerca volvulus | 0.002 | 0.0128 | 0.3411 | |
| Brugia malayi | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Plasmodium falciparum | calcium-dependent protein kinase 5 | 0.0039 | 0.0481 | 0.0404 |
| Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0025 | 0.0214 | 0.0991 |
| Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0894 | 0.3959 |
| Echinococcus multilocularis | cysteine protease | 0.002 | 0.0128 | 0.0198 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.0481 | 0.1948 |
| Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0197 | 0.0797 |
| Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0197 | 0.0797 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0481 | 0.1676 |
| Echinococcus granulosus | acetylcholinesterase | 0.0131 | 0.2258 | 0.9145 |
| Plasmodium vivax | DNA gyrase subunit B, putative | 0.006 | 0.0886 | 0.0812 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.1216 | 1 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Trichomonas vaginalis | myo-inositol transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.049 | 0.2273 |
| Trypanosoma cruzi | cysteine peptidase, putative | 0.0077 | 0.1216 | 1 |
| Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0.0106 | 0.0026 |
| Entamoeba histolytica | prolyl-tRNA synthetase, putative | 0.0038 | 0.0466 | 0.9688 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Onchocerca volvulus | 0.0022 | 0.0166 | 0.4424 | |
| Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0106 | 0.0107 |
| Echinococcus granulosus | Sugar transporter ERD6 protein | 0.0018 | 0.0081 | 0.0327 |
| Plasmodium falciparum | calcium-dependent protein kinase 4 | 0.0039 | 0.0481 | 0.0404 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.2258 | 1 |
| Plasmodium falciparum | lysine--tRNA ligase | 0.0028 | 0.028 | 0.0201 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.1216 | 1 |
| Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0197 | 0.0797 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0481 | 0.1948 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.0481 | 0.1948 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.049 | 0.2273 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Brugia malayi | hypothetical protein | 0.0022 | 0.0166 | 0.0735 |
| Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0106 | 0.0104 |
| Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.0128 | 0.2662 |
| Loa Loa (eye worm) | TOPoisomerase family member | 0.0033 | 0.0375 | 0.1662 |
| Echinococcus granulosus | neuroligin | 0.0022 | 0.0166 | 0.0672 |
| Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0106 | 0.0428 |
| Echinococcus multilocularis | acetylcholinesterase | 0.0131 | 0.2258 | 0.9116 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0128 | 0.0198 |
| Onchocerca volvulus | 0.002 | 0.0128 | 0.3411 | |
| Echinococcus multilocularis | acetylcholinesterase | 0.0131 | 0.2258 | 0.9116 |
| Leishmania major | cathepsin L-like protease | 0.002 | 0.0128 | 0.0417 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Echinococcus granulosus | General substrate transporter | 0.0108 | 0.1818 | 0.7365 |
| Giardia lamblia | Prolyl-tRNA synthetase | 0.0038 | 0.0466 | 1 |
| Trypanosoma cruzi | cysteine peptidase, putative | 0.002 | 0.0128 | 0.0417 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0481 | 0.1948 |
| Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Leishmania major | cysteine peptidase A (CPA) | 0.002 | 0.0128 | 0.0417 |
| Schistosoma mansoni | glucose transporter | 0.0018 | 0.0081 | 0.0327 |
| Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0114 | 0.192 | 0.2835 |
| Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.2469 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0166 | 0.0735 |
| Leishmania major | mitochondrial DNA topoisomerase II | 0.0033 | 0.0375 | 0.2595 |
| Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.0166 | 0.0735 |
| Brugia malayi | major facilitator superfamily protein | 0.0018 | 0.0081 | 0.0357 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0021 | 0.0151 | 0.0615 |
| Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0126 | 0.2158 | 0.3201 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.1216 | 1 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0039 | 0.0481 | 0.2229 |
| Mycobacterium ulcerans | DNA gyrase subunit B | 0.006 | 0.0886 | 0.438 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.0481 | 0.1948 |
| Loa Loa (eye worm) | fibroinase | 0.002 | 0.0128 | 0.0567 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0.0106 | 0.0139 |
| Entamoeba histolytica | protein kinase, putative | 0.0039 | 0.0481 | 1 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK3 | 0.0039 | 0.0481 | 0.0617 |
| Plasmodium vivax | calcium-dependent protein kinase 1, putative | 0.0039 | 0.0481 | 0.0404 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Plasmodium vivax | hexose transporter | 0.0126 | 0.2158 | 0.2094 |
| Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0106 | 0.0039 |
| Leishmania major | cathepsin L-like protease | 0.002 | 0.0128 | 0.0417 |
| Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.007 | 0.1088 | 0.8873 |
| Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.002 | 0.0128 | 0.0048 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0044 | 0.0586 | 0.4451 |
| Trypanosoma brucei | bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0586 | 0.4451 |
| Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0106 | 0.0428 |
| Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0027 | 0.025 | 0.1495 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Schistosoma mansoni | hypothetical protein | 0.0126 | 0.2158 | 0.8741 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0033 | 0.0375 | 0.1662 |
| Echinococcus granulosus | Polycystic kidney disease protein | 0.0024 | 0.0197 | 0.0797 |
| Echinococcus granulosus | cathepsin l1 | 0.002 | 0.0128 | 0.0519 |
| Leishmania major | glucose transporter, lmgt3 | 0.0039 | 0.049 | 0.3608 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0018 | 0.0081 | 0.0357 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Plasmodium vivax | CDK-related protein kinase 6, putative | 0.0536 | 1 | 1 |
| Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0033 | 0.0375 | 0.2595 |
| Echinococcus multilocularis | RUN | 0.0024 | 0.0197 | 0.0486 |
| Schistosoma mansoni | lysyl-tRNA synthetase | 0.0028 | 0.028 | 0.1135 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0081 | 0.0327 |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.2158 | 0.8699 |
| Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0166 | 0.0735 |
| Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0131 | 0.2258 | 0.9145 |
| Echinococcus granulosus | RUN | 0.0024 | 0.0197 | 0.0797 |
| Onchocerca volvulus | Putative transporter | 0.0018 | 0.0081 | 0.2148 |
| Onchocerca volvulus | Cathepsin F homolog | 0.002 | 0.0128 | 0.3411 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Trypanosoma cruzi | cysteine peptidase, putative | 0.0077 | 0.1216 | 1 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2158 | 0.8741 |
| Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0106 | 0.0107 |
| Schistosoma mansoni | lysyl-tRNA synthetase | 0.0028 | 0.028 | 0.1135 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Echinococcus granulosus | para nitrobenzyl esterase | 0.0022 | 0.0166 | 0.0672 |
| Brugia malayi | lysyl-tRNA synthetase | 0.0028 | 0.028 | 0.1242 |
| Trichomonas vaginalis | spcc417.12 protein, putative | 0.0022 | 0.0166 | 0.0769 |
| Schistosoma mansoni | BC026374 protein (S09 family) | 0.0022 | 0.0166 | 0.0672 |
| Trichomonas vaginalis | sugar transport protein, putative | 0.0018 | 0.0081 | 0.0374 |
| Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0022 | 0.0166 | 0.0672 |
| Leishmania major | cathepsin L-like protease | 0.002 | 0.0128 | 0.0417 |
| Brugia malayi | Carboxylesterase family protein | 0.0131 | 0.2258 | 1 |
| Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0106 | 0.0039 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase ID | 0.0039 | 0.0481 | 0.213 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.049 | 0.2273 |
| Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0106 | 0.0428 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0081 | 0.0327 |
| Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0018 | 0.0081 | 0.0357 |
| Plasmodium vivax | lysine--tRNA ligase, putative | 0.0028 | 0.028 | 0.0201 |
| Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0038 | 0.0466 | 0.1887 |
| Echinococcus granulosus | glutamyl tRNA synthetase cytoplasmic | 0.0038 | 0.0466 | 0.1887 |
| Echinococcus granulosus | cathepsin l cysteine peptidase | 0.002 | 0.0128 | 0.0519 |
| Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0106 | 0.0428 |
| Echinococcus granulosus | cathepsin L cysteine proteinase | 0.002 | 0.0128 | 0.0519 |
| Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0197 | 0.0872 |
| Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0128 | 0.0519 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Echinococcus multilocularis | Polycystic kidney disease protein | 0.0024 | 0.0197 | 0.0486 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Leishmania major | glucose transporter, lmgt1 | 0.0039 | 0.049 | 0.3608 |
| Loa Loa (eye worm) | sugar transporter | 0.0018 | 0.0081 | 0.0357 |
| Brugia malayi | hypothetical protein | 0.0024 | 0.0197 | 0.0872 |
| Plasmodium falciparum | mitogen-activated protein kinase 2 | 0.0204 | 0.3647 | 0.3595 |
| Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0106 | 0.0468 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0166 | 0.0735 |
| Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0106 | 0.0104 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Trypanosoma cruzi | cysteine peptidase, putative | 0.0077 | 0.1216 | 1 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0894 | 0.3959 |
| Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0166 | 0.0735 |
| Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0529 | 0.2343 |
| Loa Loa (eye worm) | ctsf protein | 0.002 | 0.0128 | 0.0567 |
| Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0894 | 0.3959 |
| Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0128 | 0.0198 |
| Brugia malayi | Bifunctional aminoacyl-tRNA synthetase | 0.0038 | 0.0466 | 0.2064 |
| Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0197 | 0.0797 |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0128 | 0.0567 |
| Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0131 | 0.2258 | 1 |
| Brugia malayi | Probable DNA topoisomerase II | 0.0033 | 0.0375 | 0.1662 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Plasmodium vivax | calcium-dependent protein kinase, putative | 0.0039 | 0.0481 | 0.0404 |
| Brugia malayi | Doublecortin family protein | 0.0024 | 0.0197 | 0.0872 |
| Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0024 | 0.0107 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Onchocerca volvulus | 0.002 | 0.0128 | 0.3411 | |
| Trypanosoma brucei | DNA topoisomerase ii | 0.0033 | 0.0375 | 0.2595 |
| Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0044 | 0.0586 | 0.4451 |
| Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0586 | 0.4451 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0481 | 0.1948 |
| Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0529 | 0.2143 |
| Leishmania major | lysyl-tRNA synthetase, putative | 0.0028 | 0.028 | 0.1758 |
| Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0106 | 0.0468 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2158 | 0.8741 |
| Mycobacterium tuberculosis | Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) | 0.0024 | 0.0199 | 0.0643 |
| Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0166 | 0.0735 |
| Onchocerca volvulus | 0.0022 | 0.0166 | 0.4424 | |
| Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0033 | 0.0375 | 0.1234 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0054 | 0.078 | 1 |
| Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0038 | 0.0466 | 0.1887 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Brugia malayi | Sugar transporter family protein | 0.0018 | 0.0081 | 0.0357 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2158 | 0.8741 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.028 | 0.1242 |
| Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0033 | 0.0375 | 1 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.1216 | 1 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0106 | 0.0428 |
| Schistosoma mansoni | lipoxygenase | 0.01 | 0.1648 | 0.6675 |
| Onchocerca volvulus | 0.002 | 0.0128 | 0.3411 | |
| Echinococcus multilocularis | calcium dependent protein kinase | 0.0036 | 0.0435 | 0.1485 |
| Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0114 | 0.192 | 1 |
| Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0106 | 0.0104 |
| Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.002 | 0.0128 | 0.0048 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0039 | 0.049 | 0.3608 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Schistosoma mansoni | polycystin 1-related | 0.0024 | 0.0197 | 0.0797 |
| Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Trypanosoma brucei | lysyl-tRNA synthetase, putative | 0.0028 | 0.028 | 0.1758 |
| Toxoplasma gondii | cathepsin CPL | 0.002 | 0.0128 | 0.0073 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0586 | 0.4451 |
| Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0128 | 0.0198 |
| Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0.0106 | 0.0225 |
| Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0028 | 0.028 | 0.1299 |
| Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0033 | 0.0375 | 0.0454 |
| Brugia malayi | hypothetical protein | 0.0024 | 0.0197 | 0.0872 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Brugia malayi | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Leishmania major | cathepsin L-like protease | 0.0077 | 0.1216 | 1 |
| Plasmodium vivax | calcium-dependent protein kinase 4, putative | 0.0039 | 0.0481 | 0.0404 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Schistosoma mansoni | nuclear transcription factor X-box binding 1 (nfx1) | 0.0018 | 0.0081 | 0.0327 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0481 | 0.1676 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Trichomonas vaginalis | glucose transporter, putative | 0.0039 | 0.049 | 0.2273 |
| Brugia malayi | major facilitator superfamily protein | 0.0018 | 0.0081 | 0.0357 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Toxoplasma gondii | lysine-tRNA ligase | 0.0028 | 0.028 | 0.0308 |
| Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0481 | 0.213 |
| Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.002 | 0.0128 | 0.0567 |
| Brugia malayi | Carboxylesterase family protein | 0.0131 | 0.2258 | 1 |
| Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0.0106 | 0.0026 |
| Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0028 | 0.028 | 0.1085 |
| Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0106 | 0.0428 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0106 | 0.043 |
| Onchocerca volvulus | 0.0018 | 0.0081 | 0.2148 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0197 | 0.0872 |
| Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0106 | 0.047 |
| Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0128 | 0.3411 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0039 | 0.0481 | 0.1948 |
| Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.002 | 0.0128 | 0.0567 |
| Toxoplasma gondii | cell-cycle-associated protein kinase MAPK, putative | 0.0204 | 0.3647 | 0.5495 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0126 | 0.2158 | 1 |
| Plasmodium falciparum | DNA gyrase subunit B | 0.006 | 0.0886 | 0.0812 |
| Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0033 | 0.0375 | 1 |
| Schistosoma mansoni | gliotactin | 0.0022 | 0.0166 | 0.0672 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2158 | 0.8741 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0466 | 0.2064 |
| Plasmodium falciparum | calcium-dependent protein kinase 3 | 0.0039 | 0.0481 | 0.0404 |
| Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.2258 | 1 |
| Plasmodium vivax | DNA topoisomerase II, putative | 0.0033 | 0.0375 | 0.0297 |
| Plasmodium falciparum | hexose transporter | 0.0126 | 0.2158 | 0.2094 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Trichomonas vaginalis | glucose transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Giardia lamblia | DNA topoisomerase II | 0.003 | 0.032 | 0.6225 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0166 | 0.0735 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0081 | 0.0327 |
| Plasmodium vivax | vivapain-2 | 0.002 | 0.0128 | 0.0048 |
| Plasmodium falciparum | proline--tRNA ligase | 0.0044 | 0.0586 | 0.051 |
| Toxoplasma gondii | protein kinase, putative | 0.0357 | 0.657 | 1 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0022 | 0.0166 | 0.0464 |
| Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0033 | 0.0375 | 0.2595 |
| Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0106 | 0.0225 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Leishmania major | cathepsin L-like protease | 0.002 | 0.0128 | 0.0417 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.006 | 0.0886 | 0.438 |
| Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0166 | 0.0735 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0033 | 0.0375 | 0.1739 |
| Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0106 | 0.0225 |
| Chlamydia trachomatis | DNA gyrase subunit B | 0.006 | 0.0886 | 0.3695 |
| Plasmodium vivax | mitogen-activated protein kinase 2, putative | 0.0204 | 0.3647 | 0.3595 |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0128 | 0.0567 |
| Leishmania major | DNA topoisomerase ii | 0.0027 | 0.025 | 0.1495 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.2158 | 0.8741 |
| Echinococcus multilocularis | General substrate transporter | 0.0108 | 0.1818 | 0.7276 |
| Plasmodium vivax | proline--tRNA ligase, putative | 0.0044 | 0.0586 | 0.051 |
| Echinococcus granulosus | carboxylesterase 5A | 0.0131 | 0.2258 | 0.9145 |
| Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0106 | 0.047 |
| Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0022 | 0.0166 | 0.0672 |
| Trypanosoma brucei | calcium/calmodulin-dependent protein kinase, putative | 0.0039 | 0.0481 | 0.3525 |
| Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.002 | 0.0128 | 0.0048 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0081 | 0.0357 |
| Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0166 | 0.0735 |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0128 | 0.0567 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0081 | 0.0374 |
| Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0021 | 0.0149 | 0.0105 |
| Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0894 | 0.3959 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0081 | 0.0327 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0197 | 0.0486 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.0481 | 0.1948 |
| Plasmodium vivax | calcium-dependent protein kinase 3, putative | 0.0039 | 0.0481 | 0.0404 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.0081 | 0.0357 |
| Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0106 | 0.0468 |
| Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.1216 | 1 |
| Loa Loa (eye worm) | sugar transporter | 0.0126 | 0.2158 | 0.9559 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.2158 | 0.8741 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.049 | 0.3608 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0081 | 0.0374 |
| Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0027 | 0.025 | 0.1495 |
| Trichomonas vaginalis | prolyl-tRNA synthetase, putative | 0.0038 | 0.0466 | 0.2159 |
| Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0106 | 0.047 |
| Echinococcus multilocularis | glutamyl tRNA synthetase cytoplasmic | 0.0038 | 0.0466 | 0.1614 |
| Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0106 | 0.0468 |
| Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0529 | 0.2343 |
| Plasmodium vivax | vivapain-2 | 0.002 | 0.0128 | 0.0048 |
| Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0128 | 0.0593 |
| Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0126 | 0.2158 | 0.8699 |
| Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0166 | 0.0735 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| AC50 (binding) | 20 uM | PubChem BioAssay. Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
| EC50 (functional) | = 218 nM | MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). | ChEMBL. | No reference |
| Growth Inhibition (functional) | = 8.5536 % | MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. | ChEMBL. | No reference |
| IC50 (functional) | = 1451 nM | MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. | ChEMBL. | No reference |
| IC50 (functional) | > 12000 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | > 12000 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | > 12000 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: 3H-Hyoxanthine uptake assay; RPMI 1640 (Invitrogen cat#11875-093) with Sodium Bicarbonate (NaHCO3) 2000 mg/mL. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: Modified 3H-Hyoxanthine uptake assay; RPMI 1640 (Invitrogen cat#23400-013) without Sodium Bicarbonate (NaHCO3). | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: 3H-Hyoxanthine uptake assay; 5% O2, 5% CO2 in N2. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: Modified 3H-Hyoxanthine uptake assay; 1% O2, 5% CO2 in N2. | ChEMBL. | No reference |
| IC50 (functional) | > 2.5 uM | MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. | ChEMBL. | No reference |
| IC50 (functional) | > 2.5 uM | MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. | ChEMBL. | No reference |
| IC50 (functional) | = 16.2279415130615 uM | MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. | ChEMBL. | No reference |
| IC50 (functional) | = 16.227941513061523 uM | MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. | ChEMBL. | No reference |
| IC50 (functional) | 20 uM | PubChem BioAssay. Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
| IC50 (functional) | > 30 uM | MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. | ChEMBL. | No reference |
| IC50 (functional) | > 30 uM | MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. | ChEMBL. | No reference |
| IC50 (functional) | > 32 uM | MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). | ChEMBL. | No reference |
| IC50 (functional) | > 32 uM | MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). | ChEMBL. | No reference |
| IC50 (functional) | > 32 uM | MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). | ChEMBL. | No reference |
| IC50 (functional) | 50 uM | PubChem BioAssay. Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Inhibition (functional) | = -14.5676786787323 % | MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. | ChEMBL. | No reference |
| Inhibition (functional) | = -14.56767867873228 % | MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. | ChEMBL. | No reference |
| Inhibition (functional) | = -0.006896020389772772 % | MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = -0.00689602038977277 % | MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 0.0616 % | MMV: Screen against Mtb, single point, replicating, at 25uM | ChEMBL. | No reference |
| Inhibition (functional) | = 3.48311496247367 % | MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 4.53 % | MMV: Screen against Mtb, single point, non replicating, at 25uM | ChEMBL. | No reference |
| Inhibition (functional) | = 6 % | MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). | ChEMBL. | No reference |
| Inhibition (functional) | = 18.253651532288398 % | MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 18.2536515322884 % | MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 29 % | MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). | ChEMBL. | No reference |
| IZ | = 0 mm | MMV: Selection for compounds that exhibit enhanced toxicity in combination with artemisinin. Assay utilized the disc diffusion method with the observance of a clear zone indicating inhibition of growth. Synthetic complete medium containing 3% glycerol as a carbon source (SCG) was used in each assay. 10 uL of each compound was added to a paper disc which was placed on SCG and SCG+Artemisinin (0.2 uM) plates seeded with 10e6 yeast cells (WC081 strain: Mat a, leu2 delta 0, lys2 delta 0, ura3 delta 0, his3 delta 1, pdr1 delta::HIS3, pdr3 delta::kanMX4, derived from BY4742, regulators of Multi-drug resistance transporters have been deleted to enhance toxicity of compounds). Plates were incubated at 30 degrees C for 5 days and clear zones were measured. Compounds that produced a larger clear zone in the presence of artemisinin was considered to have an additive interaction with artemisinin. Results are reported as diameter of clear zone on SCG+artemisinin plates - diameter of clear zone on SCG plates without artemisinin. | ChEMBL. | No reference |
| Potency (functional) | 0.6573 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (functional) | 1.4716 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] | ChEMBL. | No reference |
| Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 14.581 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
| Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)] | ChEMBL. | No reference |
| Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
| Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] | ChEMBL. | No reference |
| Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
| Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
| Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
| Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
| Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
| Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
| Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
| Ratio (functional) | = 0.925 | MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. | ChEMBL. | No reference |
| Relative Growth (functional) | = -0.3246 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Relative Growth (functional) | = -0.0942 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Relative Growth (functional) | = -0.0942 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Toxicity (functional) | = 0 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
| Toxicity (functional) | = 0 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
| Toxicity (functional) | = 0 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
| Species name | Source | Reference | Is orphan |
|---|---|---|---|
| Plasmodium falciparum | ChEMBL23 | ||
| Leishmania infantum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1459149
Bibliographic References
No literature references available for this target.
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