Detailed information for compound 1368566

Basic information

Technical information
  • TDR Targets ID: 1368566
  • Name: 3-[[1-(1,3-benzodioxol-5-ylmethyl)tetrazol-5- yl]-pyrrolidin-1-ylmethyl]-8-methyl-1H-quinol in-2-one
  • MW: 444.486 | Formula: C24H24N6O3
  • H donors: 1 H acceptors: 5 LogP: 3.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc2c(C)cccc2cc1C(c1nnnn1Cc1ccc2c(c1)OCO2)N1CCCC1
  • InChi: 1S/C24H24N6O3/c1-15-5-4-6-17-12-18(24(31)25-21(15)17)22(29-9-2-3-10-29)23-26-27-28-30(23)13-16-7-8-19-20(11-16)33-14-32-19/h4-8,11-12,22H,2-3,9-10,13-14H2,1H3,(H,25,31)
  • InChiKey: RYCAEYBFASCZEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[1-(1,3-benzodioxol-5-ylmethyl)tetrazol-5-yl]-pyrrolidin-1-yl-methyl]-8-methyl-1H-quinolin-2-one
  • 3-[[1-(1,3-benzodioxol-5-ylmethyl)-5-tetrazolyl]-1-pyrrolidinylmethyl]-8-methyl-1H-quinolin-2-one
  • 3-[[1-(1,3-benzodioxol-5-ylmethyl)tetrazol-5-yl]-pyrrolidin-1-yl-methyl]-8-methyl-carbostyril
  • 3-[[1-(1,3-benzodioxol-5-ylmethyl)-1,2,3,4-tetrazol-5-yl]-pyrrolidin-1-yl-methyl]-8-methyl-1H-quinolin-2-one
  • 3-[(1-Benzo[1,3]dioxol-5-ylmethyl-1H-tetrazol-5-yl)-pyrrolidin-1-yl-methyl]-8-methyl-1H-quinolin-2-one
  • MLS000072582
  • SMR000004437
  • MLS000882385
  • ASN 05340593
  • Oprea1_704646

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.1097 0.2551
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0502 0.0502
Plasmodium vivax glutathione reductase, putative 0.0046 0.0407 0.1817
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0153 0.0153
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0153 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0381 0.1766
Entamoeba histolytica cysteine proteinase, putative 0.018 0.1969 0.4808
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Loa Loa (eye worm) hypothetical protein 0.0159 0.1723 0.1723
Echinococcus multilocularis solute carrier family 5 0.004 0.0345 0.0345
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0381 0.1056
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1222 0.3818
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0303 0.0303
Brugia malayi glutathione reductase 0.0046 0.0407 0.0407
Giardia lamblia Cysteine protease 0.0054 0.0502 0.1129
Mycobacterium tuberculosis Conserved protein 0.0043 0.0381 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1879 0.5978
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Echinococcus granulosus cpg binding protein 0.0032 0.0247 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0381 0.0323
Loa Loa (eye worm) glutathione reductase 0.0046 0.0407 0.0407
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.003
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0111 0.0111
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0111 0.0111
Echinococcus granulosus cathepsin l cysteine peptidase 0.018 0.1969 0.1969
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0105 0.1097 0.1043
Schistosoma mansoni inositol transporter 0.004 0.0345 0.0345
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Echinococcus granulosus lamin dm0 0.0028 0.0206 0.0206
Schistosoma mansoni cpg binding protein 0.0032 0.0247 0.0247
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0307 0.344 0.344
Onchocerca volvulus Cathepsin F homolog 0.018 0.1969 0.614
Loa Loa (eye worm) hypothetical protein 0.0045 0.0395 0.0395
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.0345 0.0345
Loa Loa (eye worm) papain family cysteine protease containing protein 0.018 0.1969 0.1969
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.2549 0.2504
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Schistosoma mansoni cpg binding protein 0.0032 0.0247 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.1097 0.3067
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0262 0.0262
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0054 0.0502 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0502 0.1129
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0111 0.0111
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.0345 0.0345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Trypanosoma cruzi cysteine protease, putative 0.0105 0.1097 0.1043
Trypanosoma cruzi cruzipain precursor, putative 0.023 0.2549 0.2504
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Echinococcus granulosus RUN 0.0024 0.0153 0.0153
Loa Loa (eye worm) cathepsin B 0.0307 0.344 0.344
Loa Loa (eye worm) cysteine protease 0.018 0.1969 0.1969
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.1097 0.2551
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1087 0.471
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0502 0.1129
Giardia lamblia Hypothetical protein 0.0054 0.0502 0.1129
Leishmania major cathepsin L-like protease 0.018 0.1969 0.5647
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0381 0.0381
Entamoeba histolytica cysteine protease, putative 0.018 0.1969 0.4808
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0681 0.204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Echinococcus granulosus cathepsin L 0.0054 0.0502 0.0502
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0651 0.0651
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0153 0.0153
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0502 0.1566
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3975 1
Trypanosoma cruzi cysteine proteinase, putative 0.0105 0.1097 0.1043
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.0345 0.0345
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0381 0.1056
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0381 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.0345 0.0345
Leishmania major cathepsin L-like protease 0.023 0.2549 0.7364
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Toxoplasma gondii cathepsin CPC1 0.0054 0.0502 0.1307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0502 0.1129
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.018 0.1969 0.4874
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1087 0.3374
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0111 0.0111
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0111 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0111 0.0111
Schistosoma mansoni lipoxygenase 0.0024 0.0153 0.0153
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1222 0.3818
Plasmodium vivax vivapain-2 0.018 0.1969 1
Loa Loa (eye worm) fibroinase 0.018 0.1969 0.1969
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.1097 0.1097
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0728 0.0728
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Echinococcus multilocularis high affinity choline transporter 1 0.0366 0.4125 0.4125
Plasmodium vivax serine-repeat antigen (SERA) 0.0054 0.0502 0.2315
Echinococcus multilocularis cathepsin L cysteine protease 0.018 0.1969 0.1969
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0651 0.0651
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0153 0.0153
Schistosoma mansoni cathepsin s 0.0051 0.0471 0.0471
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0262 0.0262
Schistosoma mansoni rab6-interacting 0.0024 0.0153 0.0153
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0872 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Giardia lamblia Cysteine protease 0.0054 0.0502 0.1129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Plasmodium falciparum cysteine proteinase falcipain 3 0.018 0.1969 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Schistosoma mansoni lamin 0.0028 0.0206 0.0206
Brugia malayi PXA domain containing protein 0.002 0.0111 0.0111
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1095 0.1095
Onchocerca volvulus 0.0028 0.0206 0.0643
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.1374 0.3356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Schistosoma mansoni lamin 0.0028 0.0206 0.0206
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.3975 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0054 0.0502 0.1129
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0072 0.0709 0.0709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0262 0.0262
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0381 0.1766
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2803 0.2803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.1097 0.3067
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.018 0.1969 0.4874
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0206
Echinococcus multilocularis cathepsin b 0.0872 1 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0381 0.1766
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Trypanosoma brucei cysteine peptidase C (CPC) 0.0307 0.344 1
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Echinococcus multilocularis cathepsin l cysteine peptidase 0.018 0.1969 0.1969
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Trypanosoma brucei trypanothione reductase 0.0046 0.0407 0.1026
Echinococcus multilocularis expressed protein 0.0393 0.4439 0.4439
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0206 0.0206
Brugia malayi cathepsin L-like precursor 0.0129 0.1374 0.1374
Brugia malayi intermediate filament protein 0.0028 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0111 0.0111
Brugia malayi CXXC zinc finger family protein 0.003 0.0227 0.0227
Onchocerca volvulus Cathepsin L homolog 0.018 0.1969 0.614
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0395 0.0337
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0381 0.1056
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0681 0.0681
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0054 0.0502 0.2315
Brugia malayi cathepsin Z-like cysteine proteinase 0.0054 0.0502 0.0502
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0728 0.3672
Echinococcus granulosus cathepsin l1 0.018 0.1969 0.1969
Echinococcus granulosus cathepsin L cysteine proteinase 0.018 0.1969 0.1969
Trypanosoma cruzi major cysteine proteinase, putative 0.0104 0.1082 0.1028
Loa Loa (eye worm) hypothetical protein 0.018 0.1969 0.1969
Echinococcus granulosus dnaJ subfamily B 0.043 0.4876 0.4876
Leishmania major cathepsin L-like protease 0.023 0.2549 0.7364
Schistosoma mansoni intermediate filament proteins 0.0028 0.0206 0.0206
Brugia malayi Sodium:solute symporter family protein 0.004 0.0345 0.0345
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0054 0.0502 0.2315
Giardia lamblia Cathepsin B precursor 0.0307 0.344 0.8632
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0111 0.0111
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Plasmodium vivax unspecified product 0.0105 0.1097 0.5431
Schistosoma mansoni loxhd1 0.0024 0.0153 0.0153
Onchocerca volvulus 0.0043 0.0381 0.119
Loa Loa (eye worm) hypothetical protein 0.0129 0.1374 0.1374
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0054 0.0502 0.2315
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.018 0.1969 0.1969
Toxoplasma gondii ABC1 family protein 0.0043 0.0381 0.095
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0036 0.0036
Echinococcus multilocularis GPCR, family 2 0.0033 0.0262 0.0262
Echinococcus multilocularis cathepsin L 0.0054 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Leishmania major hypothetical protein, conserved 0.0043 0.0381 0.095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Trypanosoma cruzi cysteine proteinase, putative 0.0105 0.1097 0.1043
Mycobacterium tuberculosis Conserved protein 0.0043 0.0381 0.1056
Brugia malayi cathepsin L-like cysteine proteinase 0.0054 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0366 0.4125 0.4125
Onchocerca volvulus 0.018 0.1969 0.614
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.1097 0.2551
Giardia lamblia Cysteine protease 0.0054 0.0502 0.1129
Giardia lamblia Cathepsin B precursor 0.0307 0.344 0.8632
Echinococcus granulosus cathepsin b 0.0872 1 1
Echinococcus multilocularis RUN 0.0024 0.0153 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0502 0.0502
Onchocerca volvulus 0.018 0.1969 0.614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Trichomonas vaginalis esterase, putative 0.0043 0.0381 0.082
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0381 0.082
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1095 0.1095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Leishmania major cathepsin L-like protease 0.018 0.1969 0.5647
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1087 0.3374
Echinococcus granulosus expressed protein 0.0393 0.4439 0.4439
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0395 0.0991
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0012 0.0012
Onchocerca volvulus 0.0043 0.0381 0.119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Plasmodium vivax serine-repeat antigen (SERA) 0.0054 0.0502 0.2315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Plasmodium vivax vivapain-2 0.018 0.1969 1
Brugia malayi beta-lactamase family protein 0.0043 0.0381 0.0381
Echinococcus granulosus solute carrier family 5 0.004 0.0345 0.0345
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0303 0.0303
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0051 0.0471 0.0471
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0262 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0502 0.1129
Leishmania major trypanothione reductase 0.0046 0.0407 0.1026
Giardia lamblia Cathepsin L-like protease 0.0054 0.0502 0.1129
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.2549 0.2504
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Echinococcus multilocularis cysteine protease 0.018 0.1969 0.1969
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0728 0.0728
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0111 0.0111
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0395 0.0855
Onchocerca volvulus 0.0129 0.1374 0.4286
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0681 0.0681
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0395 0.0395
Plasmodium falciparum glutathione reductase 0.0046 0.0407 0.1817
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Onchocerca volvulus 0.018 0.1969 0.614
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Brugia malayi Papain family cysteine protease containing protein 0.0105 0.1097 0.1097
Loa Loa (eye worm) hypothetical protein 0.004 0.0345 0.0345
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0036 0.0036
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Echinococcus granulosus intermediate filament protein 0.0028 0.0206 0.0206
Entamoeba histolytica cysteine proteinase 1, putative 0.0105 0.1097 0.2551
Onchocerca volvulus 0.004 0.0345 0.1076
Giardia lamblia Hypothetical protein 0.0054 0.0502 0.1129
Brugia malayi hypothetical protein 0.0024 0.0153 0.0153
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0054 0.0502 0.2315
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0307 0.344 0.34
Onchocerca volvulus 0.018 0.1969 0.614
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0407 0.1817
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0054 0.0502 0.2315
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.1097 0.2551
Brugia malayi beta-lactamase 0.0043 0.0381 0.0381
Toxoplasma gondii cathepsin CPL 0.018 0.1969 0.5647
Onchocerca volvulus 0.0043 0.0381 0.119
Schistosoma mansoni cathepsin F (C01 family) 0.018 0.1969 0.1969
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0395 0.0855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0206 0.0206
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0502 0.0502
Echinococcus granulosus cathepsin b 0.0872 1 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.0407 0.1026
Echinococcus granulosus lamin 0.0028 0.0206 0.0206
Giardia lamblia Cathepsin B precursor 0.0054 0.0502 0.1129
Brugia malayi cathepsin Z-like cysteine proteinase 0.0054 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.02
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.1097 0.1097
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0395 0.0395
Brugia malayi hypothetical protein 0.0024 0.0153 0.0153
Brugia malayi Papain family cysteine protease containing protein 0.018 0.1969 0.1969
Brugia malayi Cathepsin L-like precursor 0.0129 0.1374 0.1374
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0414 0.0414
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Giardia lamblia Cathepsin L-like protease 0.0054 0.0502 0.1129
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0129 0.1374 0.1374
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0395 0.0337
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0054 0.0502 0.2315
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0395 0.0395
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0502 0.0444
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.2549 0.2504
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0471 0.0413
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0395 0.0395
Loa Loa (eye worm) ctsf protein 0.018 0.1969 0.1969
Echinococcus multilocularis cathepsin l cysteine peptidase 0.018 0.1969 0.1969
Echinococcus multilocularis dnaJ subfamily B 0.043 0.4876 0.4876
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0054 0.0502 0.1129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1097 0.2647
Echinococcus granulosus axis inhibition protein axin 0.002 0.0111 0.0111
Plasmodium falciparum thioredoxin reductase 0.0046 0.0407 0.1817
Mycobacterium ulcerans lipase LipD 0.0043 0.0381 0.1766
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0381 0.1056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Echinococcus granulosus cathepsin L cysteine protease 0.0105 0.1097 0.1097
Leishmania major cysteine peptidase A (CPA) 0.018 0.1969 0.5647
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Toxoplasma gondii preprocathepsin c precursor, putative 0.0054 0.0502 0.1307
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0303 0.0303
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0728 0.3672
Schistosoma mansoni high-affinity choline transporter 0.0366 0.4125 0.4125
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0111 0.0111
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1879 1
Schistosoma mansoni cpg binding protein 0.003 0.0227 0.0227
Echinococcus multilocularis cathepsin L cysteine protease 0.018 0.1969 0.1969
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0111 0.0111
Brugia malayi hypothetical protein 0.0159 0.1723 0.1723
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0627 0.0627
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0395 0.0395
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.028 0.028
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Onchocerca volvulus Cathepsin L homolog 0.018 0.1969 0.614
Plasmodium vivax unspecified product 0.0054 0.0502 0.2315
Brugia malayi hypothetical protein 0.002 0.0111 0.0111
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0054 0.0502 0.1129
Onchocerca volvulus 0.0054 0.0502 0.1566
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0872 1 1
Echinococcus multilocularis musashi 0.0028 0.0206 0.0206
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0872 1 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0111 0.0129
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0728 0.1976
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0381 0.0381
Entamoeba histolytica cysteine proteinase 2 0.0105 0.1097 0.2551
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0681 0.3413
Leishmania major cathepsin L-like protease 0.018 0.1969 0.5647
Onchocerca volvulus 0.018 0.1969 0.614
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1087 0.3374
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0381 0.0381
Brugia malayi Cathepsin L-like precursor 0.0051 0.0471 0.0471
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0111 0.0111
Echinococcus multilocularis lamin dm0 0.0028 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0381 0.1056
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.3975 1
Schistosoma mansoni hypothetical protein 0.043 0.4876 0.4876
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.1374 0.3356
Schistosoma mansoni cathepsin F (C01 family) 0.018 0.1969 0.1969
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0111 0.0111
Plasmodium falciparum serine repeat antigen 1 0.0054 0.0502 0.2315
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0728 0.1976
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0728 0.0728
Trypanosoma cruzi cysteine peptidase, putative 0.0105 0.1097 0.1043
Entamoeba histolytica hypothetical protein 0.0054 0.0502 0.1013
Toxoplasma gondii cathepsin B 0.0307 0.344 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Onchocerca volvulus 0.0287 0.3206 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Leishmania major cathepsin L-like protease 0.023 0.2549 0.7364
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0111 0.0111
Brugia malayi Cathepsin L-like precursor 0.018 0.1969 0.1969
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0395 0.0855
Schistosoma mansoni sodium/solute symporter 0.004 0.0345 0.0345
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0227 0.0227
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0054 0.0502 0.1129
Plasmodium falciparum serine repeat antigen 5 0.0054 0.0502 0.2315
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0502 0.1129
Loa Loa (eye worm) hypothetical protein 0.0024 0.0153 0.0153
Mycobacterium tuberculosis Probable reductase 0.0104 0.1087 0.3374
Giardia lamblia Cathepsin L precursor 0.0054 0.0502 0.1129
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Schistosoma mansoni axis inhibition protein axin 0.002 0.0111 0.0111
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0407 0.0407
Entamoeba histolytica cysteine proteinase, putative 0.018 0.1969 0.4808
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0054 0.0502 0.1129
Loa Loa (eye worm) hypothetical protein 0.0872 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0111 0.0111
Mycobacterium tuberculosis Conserved protein 0.0043 0.0381 0.1056
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0054 0.0502 0.0502
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0111 0.0111
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0053 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0381 0.1683
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0111 0.0111
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3975 1
Onchocerca volvulus 0.0159 0.1723 0.5375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0381 0.082
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0407 0.0349
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0636 0.0636
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0395 0.0395
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.006 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0262 0.0262
Giardia lamblia Cathepsin B precursor 0.0054 0.0502 0.1129
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0681 0.0681
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0051 0.0471 0.0471
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0502 0.1129
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.1097 0.1097
Echinococcus granulosus cysteine protease 0.0105 0.1097 0.1097
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0728 0.0728
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0681 0.3413
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0502 0.1129
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0502 0.0502
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0054 0.0502 0.0502
Entamoeba histolytica cysteine proteinase, putative 0.0129 0.1374 0.3269
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0395 0.0855
Schistosoma mansoni rab6-interacting 0.0024 0.0153 0.0153
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0872 1 1
Loa Loa (eye worm) RGS-3 protein 0.002 0.0111 0.0111
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0872 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0709 0.0709
Onchocerca volvulus 0.018 0.1969 0.614
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0407 0.114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0179 0.1954 0.1906
Schistosoma mansoni cathepsin S (C01 family) 0.0054 0.0502 0.0502
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0054 0.0502 0.2315
Leishmania major cathepsin L-like protease 0.018 0.1969 0.5647
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Onchocerca volvulus 0.0037 0.0303 0.0944
Echinococcus granulosus axis inhibition protein axin 0.002 0.0111 0.0111
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0681 0.1837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0502 0.1129
Plasmodium falciparum serine repeat antigen 3 0.0054 0.0502 0.2315
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0307 0.344 0.8632
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0129 0.1374 0.1374
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0153 0.0486
Giardia lamblia Cathepsin B precursor 0.0054 0.0502 0.1129
Plasmodium falciparum serine repeat antigen 2 0.0054 0.0502 0.2315
Leishmania major cathepsin L-like protease 0.018 0.1969 0.5647
Plasmodium vivax SET domain protein, putative 0.0037 0.0303 0.1271
Echinococcus multilocularis lamin 0.0028 0.0206 0.0206
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0502 0.0502
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1087 0.3374
Mycobacterium ulcerans hypothetical protein 0.0043 0.0381 0.1766
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0471 0.0413
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0054 0.0502 0.1129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Plasmodium vivax unspecified product 0.0051 0.0471 0.2152
Loa Loa (eye worm) hypothetical protein 0.0105 0.1095 0.1095
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0681 0.0681
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0054 0.0502 0.1013
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.004 0.0345 0.0843
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0153 0.0153
Brugia malayi GH02984p 0.0366 0.4125 0.4125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1097 0.2647
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0054 0.0502 0.2315
Plasmodium vivax vivapain-3 0.0105 0.1097 0.5431
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1222 0.5611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0502 0.1129
Brugia malayi hypothetical protein 0.002 0.0111 0.0111
Brugia malayi PXA domain containing protein 0.002 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0033 0.0262 0.0262
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0381 0.082
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0054 0.0502 0.2315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0303 0.0303
Echinococcus multilocularis cysteine protease 0.018 0.1969 0.1969
Brugia malayi Cathepsin L-like cysteine proteinase 0.0129 0.1374 0.1374
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3102 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0247 0.0247
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0153 0.0486
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Toxoplasma gondii cathepsin CPC2 0.0054 0.0502 0.1307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Giardia lamblia Cathepsin B precursor 0.0054 0.0502 0.1129
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0395 0.0991
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0054 0.0502 0.2315
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0111 0.0111
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3206 0.8035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0381 0.1056
Echinococcus multilocularis cathepsin b 0.0872 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0024 0.0153 0.0153
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.006 0.5
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1879 1
Giardia lamblia Cysteine protease 0.0054 0.0502 0.1129
Brugia malayi Papain family cysteine protease containing protein 0.0105 0.1097 0.1097
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.006 0.5
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0728 0.2195
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0381 0.082
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0012 0.0012
Schistosoma mansoni cathepsin C 0.0054 0.0502 0.0502
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0054 0.0502 0.0502
Schistosoma mansoni axis inhibition protein axin 0.002 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0072 0.0709 0.0709
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0303 0.0718
Schistosoma mansoni polycystin 1-related 0.0024 0.0153 0.0153
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0111 0.0111
Entamoeba histolytica cysteine protease, putative 0.0054 0.0502 0.1013
Brugia malayi fibroinase precursor 0.0054 0.0502 0.0502
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1095 0.1095
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0111 0.0111
Plasmodium vivax vivapain-1 0.0105 0.1097 0.5431
Echinococcus granulosus cathepsin l1 0.0129 0.1374 0.1374
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0111 0.0111
Onchocerca volvulus 0.0024 0.0153 0.0477
Echinococcus granulosus high affinity choline transporter 1 0.0366 0.4125 0.4125
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0054 0.0502 0.0502
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0054 0.0502 0.0502
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0381 0.082
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Brugia malayi Pre-SET motif family protein 0.0037 0.0303 0.0303
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0262 0.0262
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.018 0.1969 0.4874
Loa Loa (eye worm) hypothetical protein 0.0051 0.0471 0.0471
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0111 0.0111
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0381 0.095
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0395 0.0395
Plasmodium falciparum serine repeat antigen 7 0.0054 0.0502 0.2315
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0111 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0054 0.0502 0.1129
Schistosoma mansoni lipoxygenase 0.0067 0.0651 0.0651
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0111 0.0111
Schistosoma mansoni cathepsin B (C01 family) 0.0054 0.0502 0.0502
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0303 0.0303
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0262 0.0262
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0054 0.0502 0.2315
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0111 0.0111
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0381 0.0381
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0471 0.0471
Plasmodium falciparum serine repeat antigen 4 0.0054 0.0502 0.2315
Entamoeba histolytica cysteine protease, putative 0.0105 0.1097 0.2551
Brugia malayi beta-lactamase family protein 0.0043 0.0381 0.0381
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0502 0.0502
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0054 0.0502 0.1013
Plasmodium falciparum serine repeat antigen 8 0.0054 0.0502 0.2315
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.0345 0.0345
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0054 0.0502 0.2315
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0395 0.0395
Brugia malayi Pre-SET motif family protein 0.0252 0.2803 0.2803
Giardia lamblia Encystation-specific protease 0.0054 0.0502 0.1129
Plasmodium falciparum serine repeat antigen 6 0.0054 0.0502 0.2315
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0502 0.0502
Brugia malayi Cathepsin L-like precursor 0.0129 0.1374 0.1374
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0502 0.1129
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0381 0.1056
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0024 0.0153 0.0153
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0307 0.344 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0381 0.0381
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0111
Onchocerca volvulus 0.003 0.0227 0.071
Onchocerca volvulus 0.0028 0.0206 0.0643
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.2549 0.7364
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0111 0.0111
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0502 0.0502
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0054 0.0502 0.2315
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0111 0.0111
Onchocerca volvulus 0.0024 0.0153 0.0477
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0502 0.0502
Loa Loa (eye worm) beta-lactamase 0.0043 0.0381 0.0381
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0153 0.0153
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0414 0.0414
Plasmodium falciparum cysteine proteinase falcipain 2a 0.018 0.1969 1
Brugia malayi Thioredoxin reductase 0.0046 0.0407 0.0407
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1087 0.3374
Brugia malayi cathepsin L precursor 0.0054 0.0502 0.0502
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3975 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0054 0.0502 0.1129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0053 0.0053
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0111 0.0111
Giardia lamblia Cathepsin B precursor 0.0307 0.344 0.8632
Trypanosoma cruzi cysteine peptidase, putative 0.018 0.1969 0.192
Giardia lamblia Cathepsin B precursor 0.0054 0.0502 0.1129
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0557 0.1469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.018 0.1969 0.4874
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0853 0.9788 0.9788
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0381 0.0323
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.0345 0.0345
Plasmodium falciparum cysteine proteinase falcipain 2b 0.018 0.1969 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0728 0.3672
Onchocerca volvulus 0.018 0.1969 0.614
Brugia malayi cathepsin F-like cysteine proteinase 0.0054 0.0502 0.0502
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.0345 0.0345
Schistosoma mansoni inositol transporter 0.004 0.0345 0.0345
Plasmodium falciparum serine repeat antigen 9 0.0054 0.0502 0.2315
Echinococcus multilocularis cathepsin L 0.0105 0.1097 0.1097
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.0381
Plasmodium falciparum cysteine proteinase falcipain 1 0.0105 0.1097 0.5431
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0051 0.0471 0.0471
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0395 0.0736
Echinococcus granulosus GPCR family 2 0.0033 0.0262 0.0262
Brugia malayi Doublecortin family protein 0.0024 0.0153 0.0153
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1222 0.3818
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.0502
Echinococcus granulosus cathepsin L 0.0105 0.1097 0.1097
Schistosoma mansoni cathepsin F (C01 family) 0.0129 0.1374 0.1374

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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