Detailed information for compound 1378740

Basic information

Technical information
  • TDR Targets ID: 1378740
  • Name: phenyl 1-(4-methylphenyl)sulfonylpyrrolidine- 2-carboxylate
  • MW: 345.413 | Formula: C18H19NO4S
  • H donors: 0 H acceptors: 3 LogP: 3.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCN1S(=O)(=O)c1ccc(cc1)C)Oc1ccccc1
  • InChi: 1S/C18H19NO4S/c1-14-9-11-16(12-10-14)24(21,22)19-13-5-8-17(19)18(20)23-15-6-3-2-4-7-15/h2-4,6-7,9-12,17H,5,8,13H2,1H3
  • InChiKey: MDVWINCYNQZXQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-methylphenyl)sulfonyl-2-pyrrolidinecarboxylic acid phenyl ester
  • 1-(4-methylphenyl)sulfonylpyrrolidine-2-carboxylic acid phenyl ester
  • MLS000097590
  • SMR000064639

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0115 0.0115
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0009 0.0166
Schistosoma mansoni hypothetical protein 0.0052 0.0288 0.0288
Onchocerca volvulus Huntingtin homolog 0.0126 0.0875 0.427
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0149 0.0149
Onchocerca volvulus Poor gastrulation protein homolog 0.0052 0.0288 0.1307
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0484 0.0484
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0394 0.3009 0.3009
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0001 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0137 0.526
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0064 0.0063
Onchocerca volvulus 0.003 0.0115 0.043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0287 0.0287
Giardia lamblia Fructose-bisphosphate aldolase 0.033 0.2504 1
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0219 0.0219
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0009 0.0148
Onchocerca volvulus Alhambra homolog 0.0033 0.0137 0.0545
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.3214 0.3214
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0169 0.0169
Echinococcus multilocularis expressed conserved protein 0.0093 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0082 0.0528 0.0527
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0071 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0287
Echinococcus multilocularis nmda type glutamate receptor 0.003 0.0115 0.0115
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.024 0.024
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0094 0.0795
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0064 0.0257
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0997 0.0997
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.003 0.0115 0.043
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0094 0.0094
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0219 0.0219
Loa Loa (eye worm) jmjC domain-containing protein 0.0105 0.0708 0.0708
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.023 0.4898
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0064 0.1349
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0094 0.0094
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Brugia malayi beta-lactamase family protein 0.0037 0.0169 0.0168
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0469 0.8942
Schistosoma mansoni hypothetical protein 0.0048 0.026 0.026
Leishmania major trypanothione reductase 0.0048 0.0261 0.556
Schistosoma mansoni jumonji domain containing protein 0.0149 0.106 0.106
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0064 0.0481
Brugia malayi jmjC domain containing protein 0.0171 0.1236 0.1236
Echinococcus multilocularis protein dispatched 1 0.0048 0.026 0.026
Trichomonas vaginalis esterase, putative 0.0037 0.0169 0.0676
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0756 0.6315
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0469 0.8942
Echinococcus multilocularis geminin 0.0193 0.1411 0.1411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0052 0.0288 0.1307
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0169 0.3211
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0469 0.0468
Mycobacterium tuberculosis Conserved protein 0.0037 0.0169 0.0959
Schistosoma mansoni serine/threonine protein kinase 0.1272 1 1
Brugia malayi jmjC domain containing protein 0.0027 0.0094 0.0093
Entamoeba histolytica hypothetical protein 0.0041 0.0201 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0169 0.3211
Plasmodium vivax JmjC domain containing protein 0.0027 0.0094 0.3594
Schistosoma mansoni cpg binding protein 0.0031 0.0123 0.0123
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0064 0.0481
Giardia lamblia PHD finger protein 15 0.0033 0.0137 0.0549
Echinococcus granulosus GPCR family 3 C terminal 0.0052 0.0288 0.0288
Brugia malayi hypothetical protein 0.0041 0.0201 0.02
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0148
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0149 0.126
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0137 0.1163
Brugia malayi jmjC domain containing protein 0.0027 0.0094 0.0093
Onchocerca volvulus 0.0268 0.2011 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0171 0.1236 0.1236
Onchocerca volvulus 0.0037 0.0169 0.0705
Echinococcus granulosus tyrosine kinase 0.003 0.0115 0.0115
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0169 0.0959
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.023 0.023
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0854 0.4868
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0009 0.0166
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0029 0.054
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0064 0.0257
Brugia malayi Cytochrome P450 family protein 0.0027 0.0089 0.0088
Brugia malayi TAR-binding protein 0.0076 0.0484 0.0483
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0064 0.0063
Echinococcus multilocularis glutamate receptor 2 0.003 0.0115 0.0115
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0469 0.0469
Trypanosoma brucei trypanothione reductase 0.0048 0.0261 0.4972
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0484 0.0484
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Schistosoma mansoni microtubule-associated protein tau 0.0741 0.5772 0.5772
Brugia malayi jmjC domain containing protein 0.0027 0.0094 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0063
Plasmodium vivax SET domain protein, putative 0.0034 0.0149 0.5696
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0094 0.1771
Onchocerca volvulus Huntingtin homolog 0.0126 0.0875 0.427
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0261 0.1484
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0064 0.0481
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.0708 0.0708
Echinococcus granulosus poly adp ribose polymerase 2 0.0082 0.0524 0.0524
Plasmodium falciparum thioredoxin reductase 0.0017 0.0009 0.0345
Loa Loa (eye worm) glutamate receptor 0.032 0.2421 0.242
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0268 0.2008 0.2008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0756 0.4307
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.023 0.1924
Brugia malayi hypothetical protein 0.0237 0.1761 0.176
Echinococcus granulosus GPCR family 2 0.0016 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0105 0.0708 0.0708
Onchocerca volvulus 0.0037 0.0169 0.0705
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0094 0.0093
Loa Loa (eye worm) hypothetical protein 0.0073 0.0459 0.0458
Brugia malayi hypothetical protein 0.0126 0.0875 0.0874
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0169 0.6475
Leishmania major extracellular receptor, putative 0.003 0.0115 0.2424
Loa Loa (eye worm) hypothetical protein 0.0153 0.1095 0.1094
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0169 0.0959
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1493 0.5965
Loa Loa (eye worm) hypothetical protein 0.0033 0.0137 0.0136
Brugia malayi glutathione reductase 0.0048 0.0261 0.026
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0009 0.0148
Schistosoma mansoni hypothetical protein 0.0041 0.02 0.02
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0009 0.0148
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0094 0.0094
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0854 0.4868
Plasmodium falciparum thioredoxin reductase 0.0048 0.0261 1
Echinococcus granulosus jumonji domain containing protein 0.0046 0.024 0.024
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0169 0.1392
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0287 0.0287
Treponema pallidum fructose-bisphosphate aldolase 0.033 0.2504 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0017 0.0633
Echinococcus multilocularis glutamate receptor 2 0.003 0.0115 0.0115
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0009
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0009 0.0076
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0469 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0484 0.0484
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.023 0.438
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0169 0.0959
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Brugia malayi beta-lactamase 0.0037 0.0169 0.0168
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0261 1
Brugia malayi Bromodomain containing protein 0.0033 0.0137 0.0136
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0171 0.1236 0.1236
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Echinococcus multilocularis protein patched 0.0042 0.0212 0.0212
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0094 0.0094
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0094 0.0094
Brugia malayi metabotropic glutamate receptor type 2 0.0156 0.1116 0.1115
Schistosoma mansoni survival motor neuron protein 0.0048 0.026 0.026
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0001 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0126 0.0875 0.0874
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0164 0.1181 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0169 0.0169
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0034 0.0146 0.0146
Echinococcus granulosus dnaJ subfamily B 0.0419 0.3214 0.3214
Entamoeba histolytica hypothetical protein 0.0023 0.0059 0.0234
Mycobacterium ulcerans hypothetical protein 0.0024 0.0064 0.0481
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.023 0.092
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0294 0.2215 0.2214
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Echinococcus granulosus poly (ADP ribose) polymerase 0.0046 0.0242 0.0242
Schistosoma mansoni hypothetical protein 0.0041 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0082 0.0528 0.0527
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.023 0.195
Trypanosoma brucei poly(adp-ribose) polymerase 0.0082 0.0524 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.1095 0.1094
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0484 0.0483
Schistosoma mansoni tyrosine kinase 0.003 0.0115 0.0115
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0137 0.0137
Loa Loa (eye worm) glutamate receptor 0.0126 0.0877 0.0876
Schistosoma mansoni hypothetical protein 0.0033 0.0137 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.026 0.0259
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0009 0.0008
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0064 0.036
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0273 0.0272
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0146
Schistosoma mansoni cpg binding protein 0.0031 0.0123 0.0123
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0115 0.0115
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0854 0.4868
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0094 0.0094
Echinococcus granulosus poly (ADP ribose) polymerase 0.0023 0.0059 0.0059
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.066 0.066
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0094 0.0094
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0169 0.0676
Onchocerca volvulus 0.0034 0.0149 0.0602
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0287 0.0287
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0009 0.0076
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0064 0.0481
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0001 0.0001
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Echinococcus multilocularis GPCR, family 3, C terminal 0.0052 0.0288 0.0288
Mycobacterium ulcerans hypothetical protein 0.0037 0.0169 0.1392
Entamoeba histolytica hypothetical protein 0.0041 0.0201 0.0804
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Schistosoma mansoni hypothetical protein 0.0193 0.1411 0.1411
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.003 0.0115 0.0115
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1272 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0064 0.0257
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0169 0.0676
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0193 0.1095
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.1753 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0052 0.0288 0.0287
Brugia malayi WGR domain containing protein 0.0082 0.0524 0.0523
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0484 0.0483
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Echinococcus multilocularis muscleblind protein 0.0153 0.1095 0.1095
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0058 0.0341 0.034
Loa Loa (eye worm) hypothetical protein 0.0237 0.1761 0.176
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0261 0.026
Echinococcus granulosus poly ADP ribose polymerase 1 0.0148 0.1056 0.1056
Mycobacterium tuberculosis Conserved protein 0.0037 0.0169 0.0959
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0997 0.0997
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0148 0.1056 0.1056
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0212 0.0212
Echinococcus granulosus tar DNA binding protein 0.0076 0.0484 0.0484
Toxoplasma gondii thioredoxin reductase 0.0048 0.0261 0.2212
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0169 0.0959
Loa Loa (eye worm) glutathione reductase 0.0048 0.0261 0.026
Leishmania major hypothetical protein, conserved 0.0037 0.0169 0.3591
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.033 0.2504 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0115 0.0114
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0469 0.8942
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Brugia malayi Receptor family ligand binding region containing protein 0.0082 0.0528 0.0527
Plasmodium falciparum JmjC domain-containing protein, putative 0.0027 0.0094 0.3594
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0029 0.0029
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0082 0.0524 0.0524
Entamoeba histolytica hypothetical protein 0.003 0.0115 0.0458
Schistosoma mansoni hypothetical protein 0.0193 0.1411 0.1411
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0001 0.0001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.023 0.092
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.033 0.2504 1
Plasmodium falciparum glutathione reductase 0.0017 0.0009 0.0345
Onchocerca volvulus Glucosylceramidase homolog 0.0193 0.1411 0.6972
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0148
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1493 0.5965
Loa Loa (eye worm) hypothetical protein 0.0082 0.0524 0.0523
Echinococcus granulosus geminin 0.0193 0.1411 0.1411
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0484 0.0483
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Echinococcus multilocularis peregrin 0.0033 0.0137 0.0137
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1761 0.1761
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0484 0.0484
Brugia malayi Pre-SET motif family protein 0.0236 0.1752 0.1751
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0009 0.0345
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi Muscleblind-like protein 0.0153 0.1095 0.1094
Loa Loa (eye worm) hypothetical protein 0.0113 0.0774 0.0773
Schistosoma mansoni protein kinase 0.003 0.0115 0.0115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0094 0.0093
Entamoeba histolytica hypothetical protein 0.0041 0.0201 0.0804
Echinococcus granulosus peregrin 0.0033 0.0137 0.0137
Schistosoma mansoni cpg binding protein 0.0029 0.011 0.011
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0001 0.0001
Trypanosoma cruzi DNA repair protein, putative 0.0019 0.0029 0.054
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0149 0.0149
Brugia malayi Inositol-1 0.0045 0.023 0.0229
Echinococcus multilocularis receptor type guanylyl cyclase 0.003 0.0115 0.0115
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0115 0.0115
Echinococcus granulosus metabotropic glutamate receptor 5 0.0394 0.3009 0.3009
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0009 0.0345
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Trypanosoma brucei DNA repair protein, putative 0.0019 0.0029 0.054
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0029 0.054
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0169 0.0676
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0064 0.1349
Brugia malayi Metabotropic glutamate receptor precursor. 0.032 0.2421 0.242
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0001 0.0001
Mycobacterium ulcerans lipase LipD 0.0037 0.0169 0.1392
Mycobacterium ulcerans beta-lactamase 0.0037 0.0169 0.1392
Brugia malayi Thioredoxin reductase 0.0048 0.0261 0.026
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0115 0.0114
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0261 0.4972
Schistosoma mansoni inositol monophosphatase 0.0045 0.023 0.023
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0169 0.0169
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0094 0.0795
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0063
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0009
Brugia malayi PHD-finger family protein 0.0033 0.0137 0.0136
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.023 0.438
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0094 0.1771
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0147 0.0146
Schistosoma mansoni tyrosine kinase 0.003 0.0115 0.0115
Echinococcus granulosus glutamate receptor 2 0.003 0.0115 0.0115
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0089 0.0088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0287 0.0286
Toxoplasma gondii ABC1 family protein 0.0037 0.0169 0.1432
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0017 0.0087
Echinococcus multilocularis microtubule associated protein 2 0.0741 0.5772 0.5772
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.1752 0.1751
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0009 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0064 0.0481
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0484 0.0484
Brugia malayi RNA binding protein 0.0076 0.0484 0.0483
Loa Loa (eye worm) hypothetical protein 0.0394 0.3009 0.3009
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0756 0.4307
Echinococcus granulosus phd:f box containing protein 0.0027 0.0094 0.0094
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0009 0.0044
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Echinococcus multilocularis cpg binding protein 0.0031 0.0123 0.0123
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0017 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0169 0.0958
Schistosoma mansoni inositol monophosphatase 0.0045 0.023 0.023
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.066 0.066
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0161 0.1159 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0756 0.4307
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0148
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0169 0.0676
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0169 0.0959
Echinococcus multilocularis muscleblind protein 1 0.0153 0.1095 0.1095
Loa Loa (eye worm) beta-lactamase 0.0037 0.0169 0.0168
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0029 0.0107 0.0107
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0137 0.0136
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0169 0.0959
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0115 0.0115
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0469 0.0468
Brugia malayi CHE-14 protein 0.0042 0.0212 0.0211
Brugia malayi hypothetical protein 0.003 0.0115 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0009 0.0036
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0001 0.0048
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0094 0.0094
Loa Loa (eye worm) RNA binding protein 0.0076 0.0484 0.0483
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0043
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0137 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0287 0.0287
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0673 0.0673
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0417 0.0416
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0001 0.0011
Mycobacterium tuberculosis Probable reductase 0.0111 0.0756 0.4307
Trichomonas vaginalis set domain proteins, putative 0.0268 0.2011 0.8031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Schistosoma mansoni metabotropic glutamate receptor 0.0156 0.1116 0.1116
Echinococcus granulosus WGR domain containing protein 0.0046 0.0242 0.0242
Brugia malayi metabotropic GABA-B receptor subtype 2 0.003 0.0115 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0469 0.1873
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0169 0.0168
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0064 0.0063
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0017 0.0065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0273 0.0272
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0364 0.277 0.277
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0201 0.0201
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.023 0.023
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0149 0.0149
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0115 0.0115
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0756 0.4307
Brugia malayi WGR domain containing protein 0.0148 0.1056 0.1055
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0212 0.0211
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.066 0.0659
Schistosoma mansoni patched 1 0.0042 0.0212 0.0212
Schistosoma mansoni metabotropic glutamate receptor 0.0268 0.2008 0.2008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0287 0.0286
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0082 0.0524 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Onchocerca volvulus 0.003 0.0115 0.043
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0854 0.7213
Echinococcus multilocularis atrial natriuretic peptide receptor 0.003 0.0115 0.0115
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.029 0.2182 0.2181
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0166
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0161 0.1159 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0137 0.1163
Brugia malayi CXXC zinc finger family protein 0.0029 0.011 0.0109
Echinococcus multilocularis GPCR, family 2 0.0016 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0287 0.0287
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0082 0.0528 0.0527
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.023 0.092
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0169 0.0959
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Schistosoma mansoni hypothetical protein 0.0041 0.02 0.02
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0027 0.0094 0.1771
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0212 0.0212
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0148 0.1056 0.422
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Echinococcus granulosus muscleblind protein 0.0153 0.1095 0.1095
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1272 1 1
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.003 0.0115 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0149 0.0149
Onchocerca volvulus 0.0029 0.011 0.0405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0287 0.0287
Onchocerca volvulus 0.0037 0.0169 0.0705
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0001 0.0011
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0009 0.0036
Onchocerca volvulus 0.0048 0.026 0.1163
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0001 0.0001
Mycobacterium tuberculosis Conserved protein 0.0037 0.0169 0.0959
Echinococcus granulosus nmda type glutamate receptor 0.003 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0041 0.02 0.02
Echinococcus multilocularis lysine specific demethylase 5A 0.0103 0.0695 0.0695
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0063
Echinococcus granulosus lysine specific demethylase 5A 0.0105 0.0708 0.0708
Echinococcus granulosus atrial natriuretic peptide receptor 0.003 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0419 0.3214 0.3214
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0287
Leishmania major hypothetical protein, conserved 0.0019 0.0029 0.0603
Plasmodium falciparum glutathione reductase 0.0048 0.0261 1
Echinococcus granulosus receptor type guanylyl cyclase 0.003 0.0115 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0212 0.0848
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0115 0.0115
Echinococcus multilocularis tyrosine kinase 0.003 0.0115 0.0115
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0009 0.0036
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Leishmania major DNA repair protein, putative 0.0019 0.0029 0.0603
Plasmodium vivax glutathione reductase, putative 0.0048 0.0261 1
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0115 0.0114
Echinococcus granulosus glutamate receptor 2 0.003 0.0115 0.0115
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0029 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0126 0.0875 0.0874
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.011 0.0109
Echinococcus granulosus poly (ADP ribose) polymerase 0.0023 0.0059 0.0059
Onchocerca volvulus 0.0024 0.0064 0.0176
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0756 0.4307
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0294 0.2215 0.2214
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0148 0.1056 0.1056
Plasmodium falciparum phd finger protein, putative 0.0033 0.0137 0.526
Echinococcus granulosus metabotropic glutamate receptor 2 0.0268 0.2008 0.2008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0149 0.0149
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0261 0.0261
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.023 1
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1761 0.1761
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0094 0.0094
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0161 0.1159 0.661
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0212 0.0212
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.003 0.0115 0.0115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0043
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0329 0.2788
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0193 0.1176
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0028
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0115 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0169 0.3211
Loa Loa (eye worm) hypothetical protein 0.0042 0.0212 0.0211
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0169 0.0168
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0009 0.0345
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0261 0.0261
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0469 0.0469
Brugia malayi jmjC domain containing protein 0.0027 0.0094 0.0093
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0134 0.0134
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0009 0.0345
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0042 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0149 0.0149
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0469 0.0469
Schistosoma mansoni hypothetical protein 0.0041 0.0201 0.0201
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.023 0.092
Echinococcus granulosus microtubule associated protein 2 0.0741 0.5772 0.5772
Echinococcus granulosus poly (ADP ribose) polymerase 0.0023 0.0059 0.0059
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0082 0.0524 0.0524
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0043
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0094 0.0094
Brugia malayi beta-lactamase family protein 0.0037 0.0169 0.0168
Leishmania major hypothetical protein, conserved 0.0027 0.0094 0.1981
Brugia malayi Guanylyl cyclase protein 23 0.003 0.0115 0.0114
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0017 0.0633
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0009 0.0148
Echinococcus granulosus expressed conserved protein 0.0093 0.0613 0.0613
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0169 0.0676
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0094 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0484 0.0484
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.6342 0.6342
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0064 0.036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0287 0.0287
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0082 0.0524 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0273 0.0272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0273 0.0272
Loa Loa (eye worm) hypothetical protein 0.0099 0.066 0.0659
Schistosoma mansoni hypothetical protein 0.0034 0.0147 0.0147
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0064 0.0481
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0001 0.0001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.023 0.438
Echinococcus granulosus cpg binding protein 0.0031 0.0123 0.0123
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0169 0.1392
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1272 1 1
Loa Loa (eye worm) inositol-1 0.0045 0.023 0.0229
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0149 0.0149
Entamoeba histolytica hypothetical protein 0.0041 0.0201 0.0804
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0064 0.0481
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0115 0.0114
Brugia malayi Pre-SET motif family protein 0.0034 0.0149 0.0148
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.066 0.2638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Trypanosoma cruzi extracellular receptor, putative 0.003 0.0115 0.2168
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0064 0.1349
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0166
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0382 0.0382
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0169 0.0958
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0093
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0201 0.0201
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0169 0.0169

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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