TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 500.481 | Formula: C22H20N4O8S
H donors: 3 H acceptors: 6 LogP: 3.98 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1)NS(=O)(=O)c1cc(ccc1NN=Cc1ccccc1OCC(=O)O)[N+](=O)[O-]
InChi: 1S/C22H20N4O8S/c1-33-18-9-6-16(7-10-18)25-35(31,32)21-12-17(26(29)30)8-11-19(21)24-23-13-15-4-2-3-5-20(15)34-14-22(27)28/h2-13,24-25H,14H2,1H3,(H,27,28)
InChiKey: PCSHDEJXEHLSFX-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references
Homo sapiens	parathyroid hormone 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed), eta	Starlite/ChEMBL	No references
Homo sapiens	EYA transcriptional coactivator and phosphatase 2	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	glutaminase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	DNA polymerase eta	Get druggable targets OG5_128521	All targets in OG5_128521
Candida albicans	similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei gambiense	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Brugia malayi	ImpB/MucB/SamB family protein	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Leishmania braziliensis	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129664	All targets in OG5_129664
Trypanosoma brucei	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania infantum	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129664	All targets in OG5_129664
Leishmania infantum	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma japonicum	ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative	Get druggable targets OG5_129664	All targets in OG5_129664
Leishmania braziliensis	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma japonicum	ko:K03509 DNA polymerase eta subunit, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma japonicum	ko:K04588 secretin receptor, putative	Get druggable targets OG5_139196	All targets in OG5_139196
Echinococcus multilocularis	dna polymerase eta	Get druggable targets OG5_128521	All targets in OG5_128521
Neospora caninum	Pc21g17280 protein, related	Get druggable targets OG5_128521	All targets in OG5_128521
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania major	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Brugia malayi	hypothetical protein	Get druggable targets OG5_129664	All targets in OG5_129664
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania mexicana	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Trypanosoma cruzi	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma cruzi	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma mansoni	eyes absent homolog	Get druggable targets OG5_129664	All targets in OG5_129664
Leishmania major	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Trypanosoma congolense	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Cryptosporidium parvum	DinB/family X-type DNA polymerase	Get druggable targets OG5_128521	All targets in OG5_128521
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma japonicum	ko:K03509 DNA polymerase eta subunit, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Candida albicans	similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions	Get druggable targets OG5_128521	All targets in OG5_128521
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania mexicana		Get druggable targets OG5_128521	All targets in OG5_128521
Echinococcus granulosus	dna polymerase eta	Get druggable targets OG5_128521	All targets in OG5_128521
Toxoplasma gondii	ImpB/MucB/SamB family protein	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0606	0.0896
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0114	0.2253	0.5437
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0606	0.0896
Brugia malayi	Na,K-ATPase alpha subunit	0.001	0.0079	0.0117
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0035	0.0597	0.0597
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Plasmodium vivax	hexose transporter	0.0114	0.2253	0.2253
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0606	0.0896
Trypanosoma cruzi	hexose transporter	0.0035	0.0606	0.6084
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.001	0.0079	0.0117
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.001	0.0079	0.1325
Mycobacterium ulcerans	hypothetical protein	0.0007	0.0017	0.0025
Echinococcus granulosus	phospholipid transporting ATPase VA	0.001	0.0079	0.0191
Leishmania major	glucose transporter, lmgt2	0.0035	0.0606	0.6084
Schistosoma mansoni	ATPase	0.001	0.0079	0.0117
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0353	0.0852
Schistosoma mansoni	phosphoserine phosphatase	0.001	0.0079	0.0117
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Loa Loa (eye worm)	hypothetical protein	0.001	0.0079	0.0117
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0606	0.6084
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0035	0.0597	0.0597
Plasmodium vivax	sugar transporter, putative	0.0016	0.0201	0.0201
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0035	0.0597	0.144
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0353	0.0852
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0079	0.0191
Trypanosoma cruzi	sugar transporter, putative	0.0016	0.0201	0.2022
Brugia malayi	Probable cation-transporting ATPase C10C6.6 in chromosome IV	0.001	0.0079	0.0117
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1021	0.2463
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trypanosoma cruzi	DNA polymerase eta, putative	0.0054	0.0996	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.001	0.0079	0.0117
Echinococcus multilocularis	cation transporting ATPase 13A3	0.001	0.0079	0.0191
Chlamydia trachomatis	metal transport ATPase	0.001	0.0079	0.1984
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0035	0.0597	0.0903
Echinococcus multilocularis	geminin	0.0205	0.4145	1
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.001	0.0079	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0333	0.0492
Leishmania major	P-type H -ATPase, putative	0.001	0.0079	0.0794
Brugia malayi	ImpB/MucB/SamB family protein	0.0054	0.0996	0.1472
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.001	0.0079	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.001	0.0079	0.0794
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0264	0.0637
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0318	0.9017
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.5437
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0298
Trypanosoma brucei	DNA polymerase kappa, putative	0.0007	0.0017	0.017
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0201	0.0298
Onchocerca volvulus		0.0016	0.0201	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.0589
Trypanosoma brucei	DNA polymerase eta, putative	0.0054	0.0996	1
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.001	0.0079	0.0191
Mycobacterium ulcerans	metal cation transporter ATPase p-type CtpE	0.001	0.0079	0.0117
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0597	0.0882
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0035	0.0597	0.0903
Schistosoma mansoni	hypothetical protein	0.0019	0.0264	0.039
Mycobacterium ulcerans	glutaminase	0.033	0.6769	1
Trypanosoma brucei	hypothetical protein, conserved	0.0007	0.0017	0.017
Onchocerca volvulus		0.0016	0.0201	1
Plasmodium vivax	copper-transporting ATPase, putative	0.001	0.0079	0.0079
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.016	0.0236
Onchocerca volvulus		0.0016	0.0201	1
Echinococcus multilocularis	phospholipid transporting ATPase IIB	0.001	0.0079	0.0191
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0353	0.3543
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.4001
Trichomonas vaginalis	ATPase, class VI, type 11C, putative	0.001	0.0079	0.0117
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.001	0.0079	0.0794
Schistosoma mansoni	hypothetical protein	0.0019	0.0264	0.039
Toxoplasma gondii	transporter, major facilitator family protein	0.0016	0.0201	0.0305
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0034	0.0582	1
Schistosoma mansoni	glucose transport protein	0.0114	0.2253	0.3329
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Echinococcus multilocularis	General substrate transporter	0.0098	0.1918	0.4627
Schistosoma mansoni	protein kinase	0.0035	0.0597	0.0882
Onchocerca volvulus		0.0016	0.0201	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Echinococcus multilocularis	cation transporting ATPase 13A1	0.001	0.0079	0.0191
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.144
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0017	0.0025
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0264	0.0637
Schistosoma mansoni	protein kinase	0.0035	0.0597	0.0882
Trypanosoma brucei	DNA polymerase kappa, putative	0.0007	0.0017	0.017
Trichomonas vaginalis	glucose transporter, putative	0.0016	0.0201	0.0298
Schistosoma mansoni	eyes absent homolog	0.0106	0.2091	0.3089
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.001	0.0079	0.0117
Brugia malayi	major facilitator superfamily protein	0.0016	0.0201	0.0298
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0606	0.0896
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0079	0.0191
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.5437
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0399	0.0962
Brugia malayi	Sugar transporter family protein	0.0016	0.0201	0.0298
Brugia malayi	polk-prov protein	0.0007	0.0017	0.0025
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0701	0.7033
Brugia malayi	Sugar transporter family protein	0.0114	0.2253	0.3329
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0264	0.0637
Mycobacterium ulcerans	cation transporter p-type ATPase a CtpA	0.001	0.0079	0.0117
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.5437
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0034	0.0582	0.9752
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.001	0.0079	0.012
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.6084
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.4001
Echinococcus granulosus	copper transporting ATPase 1	0.001	0.0079	0.0191
Giardia lamblia	Phospholipid-transporting ATPase IA, putative	0.001	0.0079	0.1359
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0353	1
Trichomonas vaginalis	sugar transport protein, putative	0.0016	0.0201	0.0298
Echinococcus granulosus	synaptic vesicle 2 protein	0.0016	0.0201	0.0486
Echinococcus granulosus	phospholipid transporting ATPase IIB	0.001	0.0079	0.0191
Brugia malayi	Sugar transporter family protein	0.0016	0.0201	0.0298
Loa Loa (eye worm)	glutaminase	0.033	0.6769	1
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0353	0.0522
Schistosoma mansoni	cation-transporting atpase 13a1 (G-box binding protein)	0.001	0.0079	0.0117
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Echinococcus granulosus	General substrate transporter	0.0098	0.1918	0.4627
Trypanosoma brucei	hypothetical protein, conserved	0.0007	0.0017	0.017
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.001	0.0079	0.0117
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0079	0.0191
Schistosoma mansoni	hypothetical protein	0.0019	0.0264	0.039
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0298
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.001	0.0079	0.0794
Trypanosoma cruzi	glucose transporter, putative	0.0016	0.0201	0.2022
Onchocerca volvulus		0.0016	0.0201	1
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.001	0.0079	0.1325
Trypanosoma cruzi	cation-transporting ATPase, putative	0.001	0.0079	0.0794
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB	0.001	0.0079	0.1359
Leishmania major	protein kinase, putative	0.0035	0.0597	0.599
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trypanosoma cruzi	hypothetical protein, conserved	0.0007	0.0017	0.017
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0353	0.0522
Trypanosoma brucei	unspecified product	0.0023	0.0353	0.3543
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.001	0.0079	0.0117
Treponema pallidum	cation-transporting ATPase, P-type	0.001	0.0079	0.6664
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0298
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.001	0.0079	0.2241
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0597	0.0882
Schistosoma mansoni	glucose transport protein	0.0114	0.2253	0.3329
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.001	0.0079	0.1325
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0399	0.6849
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0399	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0448	0.0661
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0298
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0701	0.7033
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.144
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0353	0.3543
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0264	0.039
Trypanosoma cruzi	DNA damage repair protein, putative	0.0007	0.0017	0.017
Giardia lamblia	Copper-transporting P-type ATPase	0.001	0.0079	0.1359
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0016	0.0201	0.0486
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0035	0.0606	0.6084
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0606	0.0896
Schistosoma mansoni	DNA polymerase IV / kappa	0.0007	0.0017	0.0025
Plasmodium vivax	P-type ATPase4, putative	0.001	0.0079	0.0079
Onchocerca volvulus		0.0016	0.0201	1
Brugia malayi	hypothetical protein	0.0106	0.2091	0.3089
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0353	0.3543
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1125	0.1661
Loa Loa (eye worm)	sugar transporter	0.0016	0.0201	0.0298
Brugia malayi	hypothetical protein	0.0016	0.0201	0.0298
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0701	0.7033
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0606	0.6084
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.6084
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0399	0.0589
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0399	0.0589
Onchocerca volvulus		0.0016	0.0201	1
Leishmania major	P-type H -ATPase, putative	0.001	0.0079	0.0794
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.1021	0.1508
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.2253	0.3329
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.0119	1
Treponema pallidum	hypothetical protein	0.001	0.0079	0.6664
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.001	0.0079	0.0117
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0016	0.0201	0.2022
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0353	0.0522
Echinococcus multilocularis	dna polymerase eta	0.0054	0.0996	0.2404
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1021	0.1508
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0298
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0298
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Plasmodium falciparum	copper-transporting ATPase	0.001	0.0079	0.0079
Plasmodium falciparum	DNA repair protein REV1, putative	0.0007	0.0017	0.0017
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0201	0.0298
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.001	0.0079	0.1325
Toxoplasma gondii	sugar transporter ST2	0.0016	0.0201	0.0305
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.001	0.0079	0.1325
Trypanosoma cruzi	hexose transporter, putative	0.0016	0.0201	0.2022
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1021	0.2463
Trichomonas vaginalis	glutaminase, putative	0.033	0.6769	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.144
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1021	0.2463
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0399	0.0399
Brugia malayi	hypothetical protein	0.0016	0.0201	0.0298
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0016	0.0201	0.0201
Onchocerca volvulus	Putative transporter	0.0016	0.0201	1
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0486
Trypanosoma cruzi	proton motive ATPase 1, putative	0.001	0.0079	0.0794
Onchocerca volvulus		0.0016	0.0201	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0298
Mycobacterium ulcerans	sugar transporter	0.0016	0.0201	0.0298
Giardia lamblia	Prolyl-tRNA synthetase	0.0034	0.0582	1
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.001	0.0079	0.012
Plasmodium falciparum	hexose transporter	0.0114	0.2253	0.2253
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0.0201	0.0298
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0606	0.6084
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.5437
Brugia malayi	hypothetical protein	0.0016	0.0201	0.0298
Plasmodium falciparum	proline--tRNA ligase	0.004	0.0701	0.0701
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0035	0.0597	0.0882
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0079	0.0191
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0035	0.0597	0.0597
Onchocerca volvulus		0.0016	0.0201	1
Toxoplasma gondii	P-type ATPase4, putative	0.001	0.0079	0.012
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.5437
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0726	0.1073
Entamoeba histolytica	protein kinase, putative	0.0035	0.0597	1
Brugia malayi	hypothetical protein	0.001	0.0079	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2091	0.3089
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Onchocerca volvulus		0.0016	0.0201	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.1021	0.1508
Plasmodium vivax	calcium-transporting ATPase, putative	0.001	0.0079	0.0079
Leishmania major	DNA polymerase eta, putative	0.0054	0.0996	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1021	0.1508
Toxoplasma gondii	protein kinase, putative	0.0323	0.6612	1
Loa Loa (eye worm)	glutaminase 2	0.033	0.6769	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0353	0.0522
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0.0201	0.0298
Trypanosoma brucei	glucose transporter 2A	0.0035	0.0606	0.6084
Trypanosoma brucei	P-type H+-ATPase, putative	0.001	0.0079	0.0794
Schistosoma mansoni	hypothetical protein	0.0041	0.0726	0.1073
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0582	0.086
Brugia malayi	major facilitator superfamily protein	0.0016	0.0201	0.0298
Plasmodium vivax	cation transporting ATPase, putative	0.001	0.0079	0.0079
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0701	0.7033
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.001	0.0079	0.1325
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.6084
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.001	0.0079	0.0079
Echinococcus granulosus	cation transporting ATPase 13A3	0.001	0.0079	0.0191
Leishmania major	DNA polymerase kappa, putative	0.0007	0.0017	0.017
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0399	0.0589
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.001	0.0079	0.0794
Trypanosoma cruzi	phospholipid-transporting ATPase-like protein, putative	0.001	0.0079	0.0794
Toxoplasma gondii	cation-transporting atpase family protein	0.001	0.0079	0.012
Leishmania major	DNA polymerase eta, putative	0.0038	0.066	0.6627
Leishmania major	myo-inositol/proton symporter (MIT)	0.0016	0.0201	0.2022
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0399	0.0399
Trypanosoma cruzi	DNA damage repair protein, putative	0.0007	0.0017	0.017
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0264	0.0637
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.001	0.0079	0.1325
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0035	0.0597	0.0882
Schistosoma mansoni	copper ABC transporter ATPase	0.001	0.0079	0.0117
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.001	0.0079	0.0117
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.001	0.0079	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0353	0.5915
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0399	0.0589
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0012	0.0119	0.0175
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.027	0.2715
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0606	0.6084
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0035	0.0597	0.0597
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0264	0.0637
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.004	0.0701	0.106
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.001	0.0079	0.0117
Schistosoma mansoni	hypothetical protein	0.0019	0.0264	0.039
Giardia lamblia	Hexose transporter	0.0016	0.0201	0.346
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0486
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0582	0.086
Mycobacterium tuberculosis	Probable metal cation transporter P-type ATPase CtpV	0.001	0.0079	0.2241
Toxoplasma gondii	P-type ATPase PMA1	0.001	0.0079	0.012
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1021	0.2463
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0399	0.6849
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0582	0.086
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0353	0.0852
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.001	0.0079	0.0794
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0606	0.6084
Brugia malayi	E1-E2 ATPase family protein	0.001	0.0079	0.0117
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0.0201	0.0298
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Schistosoma mansoni	cation-transporting atpase worm	0.001	0.0079	0.0117
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0016	0.0201	0.0486
Schistosoma mansoni	hypothetical protein	0.0114	0.2253	0.3329
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Schistosoma mansoni	hypothetical protein	0.0205	0.4145	0.6123
Schistosoma mansoni	cation-transporting atpase worm	0.001	0.0079	0.0117
Trypanosoma brucei	unspecified product	0.0016	0.0202	0.2025
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0485	1	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.001	0.0079	0.0117
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Mycobacterium tuberculosis	Probable metal cation transporter ATPase P-type CtpE	0.001	0.0079	0.2241
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0201	0.0298
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0185	0.3724	0.5632
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0353	0.0852
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.001	0.0079	0.1359
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0007	0.0017	0.0026
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0035	0.0597	0.0597
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0486
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0582	0.1404
Mycobacterium leprae	Probable metal cation-transporting P-type ATPase C CtpC	0.001	0.0079	0.1359
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.001	0.0079	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0264	0.039
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0486
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Toxoplasma gondii	heavy metal translocating P-type ATPase subfamily protein	0.001	0.0079	0.012
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0399	0.0589
Onchocerca volvulus		0.0016	0.0201	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0035	0.0597	0.0882
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.001	0.0079	0.012
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0201	0.0298
Trichomonas vaginalis	cation-transporting ATPase, putative	0.001	0.0079	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Onchocerca volvulus		0.0016	0.0201	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0264	0.039
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1021	0.1508
Schistosoma mansoni	glutaminase	0.033	0.6769	1
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0399	1
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.001	0.0079	0.0191
Trypanosoma cruzi	DNA polymerase eta, putative	0.0038	0.066	0.6627
Loa Loa (eye worm)	hypothetical protein	0.001	0.0079	0.0117
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0034	0.0582	0.086
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.5437
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0399	0.0589
Echinococcus granulosus	cation transporting ATPase 13A1	0.001	0.0079	0.0191
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.001	0.0079	0.0117
Entamoeba histolytica	hypothetical protein	0.0025	0.0399	0.6679
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2091	0.3089
Schistosoma mansoni	DNA polymerase eta	0.0054	0.0996	0.1472
Leishmania major	proton motive ATPase, putative	0.001	0.0079	0.0794
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.144
Trypanosoma cruzi	P-type H+-ATPase, putative	0.001	0.0079	0.0794
Echinococcus granulosus	geminin	0.0205	0.4145	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.4001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0035	0.0597	0.0597
Brugia malayi	glutaminase DH11.1	0.033	0.6769	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0.0201	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0079	0.0117
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0298
Loa Loa (eye worm)	hypothetical protein	0.001	0.0079	0.0117
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0353	1
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0007	0.0017	0.0026
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0079	0.0191
Loa Loa (eye worm)	E1-E2 ATPase	0.001	0.0079	0.0117
Mycobacterium tuberculosis	Probable cation transporter P-type ATPase D CtpD	0.001	0.0079	0.2241
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0016	0.0201	0.5705
Trypanosoma brucei	glucose transporter 1E	0.0035	0.0606	0.6084
Onchocerca volvulus		0.0016	0.0201	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.001	0.0079	0.0117
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0038	0.066	0.0998
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.001	0.0079	0.0794
Trypanosoma brucei	DNA damage repair protein, putative	0.0007	0.0017	0.017
Leishmania major	copper-transporting ATPase-like protein, putative	0.001	0.0079	0.0794
Onchocerca volvulus		0.0016	0.0201	1
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.6084
Onchocerca volvulus		0.0016	0.0201	1
Trypanosoma brucei	chrX additional, unordered contigs	0.0007	0.0017	0.017
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0582	0.1404
Trypanosoma brucei	copper-transporting ATPase-like protein, putative	0.001	0.0079	0.0794
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.001	0.0079	0.012
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.001	0.0079	0.0191
Leishmania major	glucose transporter, lmgt1	0.0035	0.0606	0.6084
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.6084
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.001	0.0079	0.0794
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0016	0.0201	0.0298
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.001	0.0079	0.0117
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0035	0.0597	0.599
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.6084
Entamoeba histolytica	cation-transporting P-typeATPase, putative	0.001	0.0079	0.1325
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0606	0.0896
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0034	0.0582	0.086
Mycobacterium ulcerans	cation transporter p-type ATPase D CtpD	0.001	0.0079	0.0117
Trypanosoma brucei	cation-transporting ATPase, putative	0.001	0.0079	0.0794
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0035	0.0597	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Echinococcus granulosus	calcium dependent protein kinase	0.0033	0.0552	0.1331
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0034	0.0582	0.086
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0353	0.0522
Schistosoma mansoni	atpase class VI type 11c	0.001	0.0079	0.0117
Schistosoma mansoni	cation-transporting ATPase	0.001	0.0079	0.0117
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.144
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0016	0.0201	0.0486
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0606	0.0896
Giardia lamblia	DNA damage repair protein	0.0007	0.0017	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1125	0.1661
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0201	0.0298
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.001	0.0079	0.0794
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.001	0.0079	0.0191
Trypanosoma brucei	DNA damage repair protein, putative	0.0007	0.0017	0.017
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.001	0.0079	0.1325
Brugia malayi	E1-E2 ATPase family protein	0.001	0.0079	0.0117
Loa Loa (eye worm)	calcium ATPase	0.001	0.0079	0.0117
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.001	0.0079	0.1325
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Echinococcus multilocularis	phospholipid transporting ATPase VA	0.001	0.0079	0.0191
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0264	0.039
Trichomonas vaginalis	myo-inositol transporter, putative	0.0016	0.0201	0.0298
Leishmania major	calcium-translocating P-type ATPase	0.001	0.0079	0.0794
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.001	0.0079	0.1359
Mycobacterium tuberculosis	Cation transporter P-type ATPase a CtpA	0.001	0.0079	0.2241
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trichomonas vaginalis	cation-transporting ATPase, putative	0.001	0.0079	0.0117
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0353	0.0522
Leishmania major	glucose transporter, lmgt3	0.0035	0.0606	0.6084
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0353	0.0522
Echinococcus granulosus	dna polymerase eta	0.0054	0.0996	0.2404
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.6084
Echinococcus multilocularis	calcium dependent protein kinase	0.0033	0.0552	0.1331
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.001	0.0079	0.0117
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0318	0.5469
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0996	0.1472
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0035	0.0597	0.0597
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0486
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0353	0.6065
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1125	0.1661
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Toxoplasma gondii	sugar transporter ST1	0.0016	0.0201	0.0305
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0022	0.0318	0.9017
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.001	0.0079	0.0794
Trichomonas vaginalis	ATPase, class I, type 8B, putative	0.001	0.0079	0.0117
Leishmania major	DNA damage repair protein, putative	0.0007	0.0017	0.017
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0202	0.2025
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.001	0.0079	0.0117
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.6084
Trypanosoma brucei	sugar transporter, putative	0.0016	0.0201	0.2022
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0353	0.0522
Schistosoma mansoni	type V p-type atpase isoform	0.001	0.0079	0.0117
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0202	0.2025
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0035	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.5437
Loa Loa (eye worm)	sugar transporter	0.0114	0.2253	0.3329
Leishmania major	hypothetical protein, conserved	0.0016	0.0201	0.2022
Mycobacterium ulcerans	metal cation transporter p-type ATPase, CtpV	0.001	0.0079	0.0117
Loa Loa (eye worm)	hypothetical protein	0.001	0.0079	0.0117
Entamoeba histolytica	protein kinase, putative	0.0035	0.0597	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.144
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0353	0.3543
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.001	0.0079	0.0117
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0202	0.2025
Echinococcus granulosus	GPCR family 2	0.0019	0.0264	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Trichomonas vaginalis	CAMK family protein kinase	0.0035	0.0597	0.0882
Schistosoma mansoni	ATPase	0.001	0.0079	0.0117
Mycobacterium ulcerans	cation-transporter ATPase I CtpI	0.001	0.0079	0.0117
Echinococcus multilocularis	phosphoserine phosphatase	0.001	0.0079	0.0191
Mycobacterium ulcerans	metal cation-transporting p-type ATPase CtpC	0.001	0.0079	0.0117
Plasmodium vivax	DNA repair protein REV1, putative	0.0007	0.0017	0.0017
Schistosoma mansoni	protein kinase	0.0035	0.0597	0.0882
Trypanosoma cruzi	hypothetical protein, conserved	0.0007	0.0017	0.017
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0035	0.0597	0.0597
Brugia malayi	Cam kinase protein 1	0.0035	0.0597	0.0882
Onchocerca volvulus		0.0016	0.0201	1
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.001	0.0079	0.0794
Plasmodium falciparum	protein kinase 7	0.0323	0.6612	0.6612
Schistosoma mansoni	glucose transport protein	0.0114	0.2253	0.3329
Loa Loa (eye worm)	hypothetical protein	0.006	0.1125	0.1661
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0701	0.7033
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0016	0.0201	0.5705
Toxoplasma gondii	sugar transporter ST3	0.0016	0.0201	0.0305
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0486
Trypanosoma cruzi	copper-transporting ATPase, putative	0.001	0.0079	0.0794
Brugia malayi	potential phospholipid-transporting ATPase IIB, putative	0.001	0.0079	0.0117
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Schistosoma mansoni	hypothetical protein	0.0205	0.4145	0.6123
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0486
Echinococcus multilocularis	cation transporting atpase worm	0.001	0.0079	0.0191
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298
Trypanosoma brucei	unspecified product	0.0016	0.0202	0.2025
Chlamydia trachomatis	proline--tRNA ligase	0.0012	0.0119	0.2978
Toxoplasma gondii	facilitative glucose transporter GT1	0.0114	0.2253	0.3408
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.001	0.0079	0.012
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.001	0.0079	0.012
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0353	0.3543
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0298
Echinococcus granulosus	cation transporting atpase worm	0.001	0.0079	0.0191
Echinococcus multilocularis	copper transporting ATPase 1	0.001	0.0079	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0582	0.086
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0185	0.3724	0.3724
Trypanosoma brucei	P-type H+-ATPase, putative	0.001	0.0079	0.0794
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.001	0.0079	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0298
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.144
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0726	0.1073
Mycobacterium ulcerans	cation-transporter p-type ATPase B CtpB	0.001	0.0079	0.0117
Schistosoma mansoni	glucose transporter	0.0016	0.0201	0.0298
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0185	0.3724	0.3724
Plasmodium vivax	proline--tRNA ligase, putative	0.004	0.0701	0.0701
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0606	0.6084
Giardia lamblia	Sugar-proton symporter	0.0016	0.0201	0.346
Trypanosoma cruzi	P-type H+-ATPase, putative	0.001	0.0079	0.0794
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0399	0.0962
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0298

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.6513 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939]	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	37.6858 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1532503

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1386858