Detailed information for compound 1395241

Basic information

Technical information
  • TDR Targets ID: 1395241
  • Name: 2-chloro-N-[5-(2-morpholin-4-yl-2-oxoethyl)su lfanyl-1,3,4-thiadiazol-2-yl]benzamide
  • MW: 398.888 | Formula: C15H15ClN4O3S2
  • H donors: 1 H acceptors: 4 LogP: 2.16 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCOCC1)CSc1nnc(s1)NC(=O)c1ccccc1Cl
  • InChi: 1S/C15H15ClN4O3S2/c16-11-4-2-1-3-10(11)13(22)17-14-18-19-15(25-14)24-9-12(21)20-5-7-23-8-6-20/h1-4H,5-9H2,(H,17,18,22)
  • InChiKey: LMGLLFYWYHDMSE-UHFFFAOYSA-N  


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Synonyms

  • 2-chloro-N-[5-(2-morpholino-2-oxo-ethyl)sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
  • 2-chloro-N-[5-[(2-morpholino-2-oxoethyl)thio]-1,3,4-thiadiazol-2-yl]benzamide
  • 2-chloro-N-[5-[(2-keto-2-morpholino-ethyl)thio]-1,3,4-thiadiazol-2-yl]benzamide
  • 2-chloro-N-[5-(2-morpholin-4-yl-2-oxo-ethyl)sulfanyl-1,3,4-thiadiazol-2-yl]benzamide
  • ZINC01838382
  • ZINC00818238
  • 2-Chloro-N-[5-(2-morpholin-4-yl-2-oxo-ethylsulfanyl)-[1,3,4]thiadiazol-2-yl]-benzamide
  • MLS000558308
  • SMR000178686
  • BAS 09627876
  • STK138806
  • ZINC01838381

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis STE family protein kinase 0.0118 0.0804 0.774
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1197 0.131
Brugia malayi MAP kinase sur-1 0.0058 0.0344 0.0344
Brugia malayi WH1 domain containing protein 0.0113 0.0767 0.0767
Schistosoma mansoni hypothetical protein 0.0049 0.0281 0.2849
Echinococcus multilocularis cyclin dependent kinase 5 0.0142 0.0985 0.1078
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.007 0.139
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0505 0.5122
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0113 0.0767 0.0767
Trichomonas vaginalis STE family protein kinase 0.0118 0.0804 0.774
Schistosoma mansoni hypothetical protein 0.0113 0.0767 0.7786
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0185 0.188
Giardia lamblia Kinase, STE STE20 0.0118 0.0804 0.7276
Entamoeba histolytica hypothetical protein 0.0113 0.0767 0.7465
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0295 0.0322
Echinococcus multilocularis protein dispatched 1 0.0058 0.0349 0.0382
Entamoeba histolytica protein kinase, putative 0.0118 0.0804 0.7899
Trypanosoma brucei protein kinase, putative 0.0058 0.0344 0.0346
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0985 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.081 0.7963
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0125 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0295 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0264 0.0985
Trichomonas vaginalis STE family protein kinase 0.0118 0.0804 0.774
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0125 0.5
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0142 0.0985 0.0985
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0344 0.0344
Schistosoma mansoni hypothetical protein 0.0032 0.0148 0.1502
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0125 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.734 0.8031
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0985 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0321 0.1701
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0344 0.1988
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0185 0.188
Trichomonas vaginalis STE family protein kinase 0.0118 0.0804 0.774
Entamoeba histolytica protein kinase, putative 0.0055 0.0321 0.2285
Schistosoma mansoni hypothetical protein 0.0049 0.0281 0.2849
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0125 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0142 0.0985 1
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0344 0.3495
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0295 0.0295
Entamoeba histolytica protein kinase, putative 0.0118 0.0804 0.7899
Trypanosoma cruzi cdc2-related kinase 3 0.0142 0.0985 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0142 0.0985 1
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0113 0.0767 0.0839
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0767 0.7786
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0079 0.0505 0.0552
Schistosoma mansoni hypothetical protein 0.0032 0.0148 0.1502
Entamoeba histolytica protein kinase, putative 0.0118 0.0804 0.7899
Echinococcus multilocularis PAK box P21 Rho binding 0.0118 0.0804 0.088
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0344 0.0346
Schistosoma mansoni protein kinase 0.0118 0.0804 0.8165
Trypanosoma cruzi cdc2-related kinase 3 0.0142 0.0985 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0142 0.0985 0.0985
Giardia lamblia Kinase, CMGC CDK 0.0142 0.0985 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0295 0.0295
Echinococcus multilocularis serine:threonine protein kinase 0.0047 0.0264 0.0289
Echinococcus granulosus cyclin dependent kinase 1 0.0142 0.0985 0.1078
Entamoeba histolytica cell division protein kinase 2, putative 0.0142 0.0985 1
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0047 0.0264 0.0264
Entamoeba histolytica p21-activated kinase 0.0118 0.0804 0.7899
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0055 0.0321 0.3262
Echinococcus granulosus serine:threonine protein kinase 0.0047 0.0264 0.0289
Brugia malayi Protein kinase domain containing protein 0.0142 0.0985 0.0985
Schistosoma mansoni tyrosine kinase 0.0113 0.0767 0.7786
Echinococcus multilocularis cyclin dependent kinase 1 0.0142 0.0985 0.1078
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0344 0.0377
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0321 0.2285
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.081 0.0886
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0118 0.0804 0.088
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0344 0.0346
Brugia malayi Protein kinase domain containing protein 0.0047 0.0264 0.0264
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0344 0.2552
Echinococcus multilocularis protein patched 0.0051 0.0295 0.0322
Brugia malayi intracellular kinase 0.0055 0.0321 0.0321
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0985 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0344 0.0346
Brugia malayi P21-Rho-binding domain containing protein 0.0113 0.0767 0.0767
Plasmodium vivax glycogen synthase kinase 3, putative 0.0055 0.0321 0.2748
Schistosoma mansoni protein kinase 0.0113 0.0767 0.7786
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0113 0.0767 0.0839
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0125 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0344 0.2552
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0125 0.0125
Echinococcus multilocularis hypothetical protein 0.0032 0.0148 0.0162
Echinococcus multilocularis expressed conserved protein 0.0112 0.0755 0.0826
Giardia lamblia Kinase, CMGC CDK 0.0142 0.0985 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0125 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0985 1
Schistosoma mansoni hypothetical protein 0.0113 0.0767 0.7786
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0125 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.007
Echinococcus multilocularis serine:threonine protein kinase 0.0047 0.0264 0.0289
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0125 0.5
Mycobacterium ulcerans hypothetical protein 0.0029 0.0125 1
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0118 0.0804 0.088
Echinococcus granulosus calcium activated potassium channel 0.0037 0.0185 0.0203
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0344 0.0346
Trypanosoma brucei cdc2-related kinase 3 0.0142 0.0985 1
Echinococcus granulosus serine:threonine protein kinase 0.0047 0.0264 0.0289
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.0148
Trypanosoma cruzi cdc2-related kinase 1 0.0142 0.0985 1
Schistosoma mansoni serine/threonine kinase 0.0037 0.0185 0.188
Echinococcus multilocularis PAK box P21 Rho binding 0.0113 0.0767 0.0839
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0344 0.0346
Trichomonas vaginalis STE family protein kinase 0.0118 0.0804 0.774
Schistosoma mansoni hypothetical protein 0.0113 0.0767 0.7786
Schistosoma mansoni hypothetical protein 0.0049 0.0281 0.2849
Echinococcus granulosus PAK box P21 Rho binding 0.0113 0.0767 0.0839
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0295 0.0322
Loa Loa (eye worm) hypothetical protein 0.0047 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0321 0.2285
Echinococcus granulosus cyclin dependent kinase 5 0.0142 0.0985 0.1078
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0079 0.0505 0.0552
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.081 0.081
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0125 0.0125
Entamoeba histolytica protein kinase, putative 0.0118 0.0804 0.7899
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0125 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0055 0.0321 0.2285
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0321 0.0321
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0142 0.0985 0.0985
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0295 0.1368
Loa Loa (eye worm) hypothetical protein 0.0119 0.081 0.081
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0079 0.0505 0.0552
Trypanosoma cruzi cdc2-related kinase 1 0.0142 0.0985 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0125 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0344 0.0377
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0344 0.0377
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0142 0.0985 0.1078
Schistosoma mansoni hypothetical protein 0.0049 0.0281 0.2849
Brugia malayi Protein kinase domain containing protein 0.0037 0.0185 0.0185
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.1216 0.914 1
Plasmodium falciparum glycogen synthase kinase 3 0.0055 0.0321 0.2748
Brugia malayi CHE-14 protein 0.0051 0.0295 0.0295
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1197 0.131
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.133 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.007
Schistosoma mansoni patched 1 0.0051 0.0295 0.2991
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0113 0.0767 0.7786
Brugia malayi P21-Rho-binding domain containing protein 0.0113 0.0767 0.0767
Brugia malayi cell division control protein 2 homolog 0.0142 0.0985 0.0985
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.1216 0.914 1
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0985 1
Onchocerca volvulus 0.0029 0.0125 0.388
Echinococcus multilocularis protein kinase shaggy 0.0055 0.0321 0.0352
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0125 0.0125
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0125 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0824 0.8362
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0344 0.1988
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0118 0.0804 0.088
Loa Loa (eye worm) hypothetical protein 0.0029 0.0125 0.0125
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0055 0.0321 0.0352
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0321 0.1701
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0118 0.0804 0.088
Plasmodium vivax protein kinase Crk2 0.0142 0.0985 1
Echinococcus granulosus expressed conserved protein 0.0112 0.0755 0.0826
Trypanosoma brucei cdc2-related kinase 1 0.0142 0.0985 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0344 0.0346
Schistosoma mansoni protein kinase 0.0118 0.0804 0.8165
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0142 0.0985 1
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0113 0.0767 0.0839
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0037 0.0185 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0505 0.5122
Brugia malayi Kinase associated domain 1 family protein 0.0032 0.0148 0.0148
Echinococcus multilocularis calcium activated potassium channel 0.0037 0.0185 0.0203
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.007
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.007 0.5
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0344 0.0346
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.007
Echinococcus granulosus cyclin dependent kinase 0.0142 0.0985 0.1078
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0118 0.0804 0.088
Loa Loa (eye worm) hypothetical protein 0.0137 0.0948 0.0948
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0125 1
Echinococcus multilocularis cyclin dependent kinase 0.0142 0.0985 0.1078
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0118 0.0804 0.088
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0079 0.0505 0.0552
Schistosoma mansoni protein kinase 0.0118 0.0804 0.8165
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.0767 0.7273
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0344 0.0377
Echinococcus granulosus protein kinase shaggy 0.0055 0.0321 0.0352
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0185 0.188
Loa Loa (eye worm) hypothetical protein 0.0062 0.0382 0.0382
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0344 0.1988
Entamoeba histolytica hypothetical protein 0.0113 0.0767 0.7465
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.081 0.0886
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0344 0.1988
Plasmodium falciparum protein kinase 5 0.0142 0.0985 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0767 0.0767
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0055 0.0321 0.0352
Onchocerca volvulus 0.0055 0.0321 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0125 0.0125
Echinococcus multilocularis cyclin dependent kinase 1 0.0142 0.0985 0.1078
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0142 0.0985 1
Brugia malayi Protein kinase domain 0.0118 0.0804 0.0804
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0321 0.0321

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8275 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.0749 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.7907 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.4921 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Giardia lamblia
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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