Detailed information for compound 1395956

Basic information

Technical information
  • TDR Targets ID: 1395956
  • Name: [5-bromo-3-(4-methoxyphenyl)-7-methyl-6,8-dio xoisochromen-7-yl] methyl butanedioate
  • MW: 491.285 | Formula: C22H19BrO8
  • H donors: 0 H acceptors: 4 LogP: 2.6 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CCC(=O)OC1(C)C(=O)C(=C2C(=COC(=C2)c2ccc(cc2)OC)C1=O)Br
  • InChi: 1S/C22H19BrO8/c1-22(31-18(25)9-8-17(24)29-3)20(26)15-11-30-16(10-14(15)19(23)21(22)27)12-4-6-13(28-2)7-5-12/h4-7,10-11H,8-9H2,1-3H3
  • InChiKey: VVZFCLWSBDXRKE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [5-bromo-3-(4-methoxyphenyl)-7-methyl-6,8-dioxo-isochromen-7-yl] methyl butanedioate
  • butanedioic acid [5-bromo-3-(4-methoxyphenyl)-7-methyl-6,8-dioxo-7-isochromenyl] ester methyl ester
  • succinic acid [5-bromo-6,8-diketo-3-(4-methoxyphenyl)-7-methyl-isochromen-7-yl] ester methyl ester
  • NCGC00161522-01
  • CMLD003391
  • MLS000438293
  • SMR000452571

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Human immunodeficiency virus type 1 Tat protein Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Echinococcus multilocularis squamous cell carcinoma antigen Human immunodeficiency virus type 1 Tat protein   86 aa 79 aa 30.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.031 0.165
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0062 0.0458 0.0607
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0056 0.0404 0.1505
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.031 0.165
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0212 0.1129
Schistosoma mansoni cpg binding protein 0.003 0.0143 0.0143
Brugia malayi Cell death protein 3 precursor 0.0308 0.2889 0.2889
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0262 0.0262
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0054 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0564 0.2998
Giardia lamblia Rab geranylgeranyltransferase 0.0021 0.0056 0.0296
Loa Loa (eye worm) hypothetical protein 0.0072 0.0564 0.0564
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0021 0.0056 0.0296
Loa Loa (eye worm) hypothetical protein 0.0072 0.0564 0.0564
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) calpain family protein 1 0.004 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0055 0.039 0.039
Leishmania major trypanothione reductase 0.0103 0.0866 0.4601
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0564 0.086
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0564 0.086
Echinococcus granulosus allatostatin A receptor 0.0176 0.1594 0.1594
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0021 0.0021
Echinococcus multilocularis calpain 5 0.0021 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0021
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0028 0.0128 0.0128
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0866 0.4601
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0054 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0262 0.0262
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0202 0.0752
Brugia malayi mbt repeat family protein 0.0048 0.0322 0.0322
Brugia malayi Phosphoglycerate kinase 0.0075 0.0595 0.0595
Onchocerca volvulus 0.0042 0.0262 0.0243
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0072 0.0564 0.0564
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0212 0.0212
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0021 0.0021
Onchocerca volvulus 0.0308 0.2889 0.2875
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0021 0.0056 0.0296
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0262 0.0262
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0021 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0167 0.089
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0021 0.0056 0.0296
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0262 0.0262
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0262 0.0262
Echinococcus granulosus dna polymerase kappa 0.0047 0.031 0.031
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0262 0.0262
Schistosoma mansoni cpg binding protein 0.0031 0.016 0.016
Schistosoma mansoni organic anion transporter 0.0028 0.0128 0.0128
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0054 0.0285
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0197 0.0197
Giardia lamblia Kinase, PLK 0.0114 0.0977 0.5195
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0021 0.0056 0.0056
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0262 0.0262
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0262 0.0262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1677 0.1677
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.031 0.165
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0262 0.0262
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0056 0.0404 0.2146
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.002
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0322 0.0322
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.031 0.031
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0406 0.1218
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.001 0.001
Echinococcus granulosus g protein coupled receptor 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.031 0.0258
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.2167 0.4666
Giardia lamblia Phosphoglycerate kinase 0.0206 0.1881 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0056 0.0296
Schistosoma mansoni agrin 0.0019 0.004 0.004
Onchocerca volvulus 0.003 0.0143 0.0123
Schistosoma mansoni neuropeptide receptor 0.0042 0.0262 0.0262
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0387 0.0387
Mycobacterium tuberculosis Probable reductase 0.0234 0.2167 0.4666
Echinococcus granulosus caspase 2 0.0308 0.2889 0.2889
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0866 0.0866
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0262 0.0262
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.002 0.0106
Plasmodium vivax glutathione reductase, putative 0.0103 0.0866 0.4601
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0302 0.2831 0.2831
Trypanosoma brucei polo-like protein kinase 0.0114 0.0977 0.5195
Loa Loa (eye worm) glutathione reductase 0.0103 0.0866 0.0866
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0406 0.216
Brugia malayi calpain family protein 1 0.0055 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Echinococcus granulosus follistatin 0.0019 0.004 0.004
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0564 0.2102
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0056 0.0404 0.0404
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.031 0.0647
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0072 0.0564 0.0564
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0406 0.216
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0212 0.0212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0262 0.0262
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0054 0.0285
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0262 0.0262
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0021
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0262 0.0262
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0262 0.0262
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.002 0.002
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0021 0.0056 0.0296
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.031 0.165
Echinococcus granulosus calpain A 0.0021 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0054 0.0387 0.0387
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0056 0.0404 0.0404
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0308 0.2889 0.2889
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.004 0.0213
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0206 0.1881 0.1881
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0021 0.0021
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0615 0.3266
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0262 0.0262
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0262 0.0262
Echinococcus granulosus cpg binding protein 0.0031 0.016 0.016
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0021 0.0056 0.0056
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.1881 0.1881
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0021 0.0021
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0056 0.0404 0.2146
Schistosoma mansoni opsin-like receptor 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0019 0.004 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0564 0.2998
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0057 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0128
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.1881 1
Echinococcus multilocularis serotonin receptor 0.0042 0.0262 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0167 0.089
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0387 0.0387
Brugia malayi calpain family protein 1 0.0055 0.039 0.039
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0021 0.0056 0.0207
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.0595 0.3165
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0202 0.1072
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.2426 0.528
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.031 0.165
Brugia malayi hypothetical protein 0.0042 0.0262 0.0262
Schistosoma mansoni DNA polymerase eta 0.0077 0.0615 0.0615
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0021 0.0021
Loa Loa (eye worm) MBCTL1 0.0054 0.0387 0.0387
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.0595 0.3165
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.2167 0.4666
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.001 0.001
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0262 0.0262
Schistosoma mansoni amine GPCR 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0042 0.0262 0.0243
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0357 0.0357
Echinococcus multilocularis cpg binding protein 0.0031 0.016 0.016
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0021 0.0001
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0595 0.3165
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0054 0.0285
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0262 0.0262
Brugia malayi hypothetical protein 0.0042 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.001
Onchocerca volvulus 0.0042 0.0262 0.0243
Toxoplasma gondii kringle domain-containing protein 0.0017 0.002 0.0106
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0202 0.1072
Echinococcus granulosus neuropeptide receptor A26 0.0504 0.4827 0.4827
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0054 0.0285
Echinococcus granulosus hypothetical protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0101 0.0845 0.0845
Onchocerca volvulus 0.0042 0.0262 0.0243
Leishmania major hypothetical protein, conserved 0.0017 0.002 0.0106
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.0262 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.031 0.165
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0262 0.0262
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0406 0.1514
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0054 0.0054
Schistosoma mansoni neuropeptide receptor 0.0042 0.0262 0.0262
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0262 0.0262
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0054 0.0285
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0595 0.3165
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0564 0.0564
Trypanosoma cruzi protein farnesyltransferase, putative 0.0056 0.0404 0.2146
Echinococcus granulosus neuropeptide receptor 0.0042 0.0262 0.0262
Brugia malayi CXXC zinc finger family protein 0.003 0.0143 0.0143
Echinococcus multilocularis serotonin receptor 0.0042 0.0262 0.0262
Leishmania major DNA polymerase kappa, putative 0.0047 0.031 0.165
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0287 0.2684 0.2669
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0021
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0021 0.0021
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0021 0.0056 0.0056
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0202 0.1072
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0262 0.0262
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.031 0.165
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0406 0.216
Echinococcus granulosus Solute carrier organic anion transporter family 0.0028 0.0128 0.0128
Echinococcus granulosus dnaJ subfamily B 0.0422 0.4026 0.4026
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0212 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0262 0.0262
Brugia malayi ecdysteroid receptor 0.0017 0.0021 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0262 0.0262
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0977 0.5195
Trypanosoma cruzi lanosterol synthase, putative 0.0062 0.0458 0.2433
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0202 0.1072
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Trypanosoma brucei lanosterol synthase 0.0062 0.0458 0.2433
Loa Loa (eye worm) hypothetical protein 0.0077 0.0615 0.0615
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0021 0.0021
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0202 0.1072
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0021 0.0021
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0406 0.1218
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.031 0.165
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0387 0.0387
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.2167 0.4666
Echinococcus granulosus apoptotic protease activating factor 1 0.0308 0.2889 0.2889
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0322 0.0322
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.1881 0.1881
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0021 0.0021
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0021 0.0056 0.0296
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0357 0.0357
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0202 0.1072
Echinococcus multilocularis caspase 2 0.0308 0.2889 0.2889
Trypanosoma cruzi lanosterol synthase, putative 0.0062 0.0458 0.2433
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8087 0.8087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0262 0.0262
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0262 0.0262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0021 0.0021
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0262 0.0262
Schistosoma mansoni neuropeptide receptor 0.0042 0.0262 0.0262
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0176 0.1594 0.1577
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi GnHR receptor homolog 0.0042 0.0262 0.0262
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0262 0.0262
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0202 0.1072
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.1677 0.1677
Onchocerca volvulus 0.0042 0.0262 0.0243
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0406 0.216
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.031 0.165
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.004 0.004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0176 0.1594 0.1594
Echinococcus granulosus calpain 0.0021 0.0054 0.0054
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0262 0.0262
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0262 0.0262
Schistosoma mansoni amine GPCR 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0017 0.0021 0.0001
Leishmania major DNA polymerase eta, putative 0.0045 0.0297 0.1577
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi putative neuropeptide receptor 0.0042 0.0262 0.0262
Brugia malayi Serotonin receptor 0.0042 0.0262 0.0262
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0202 0.1072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0056
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0595 0.3165
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0262 0.0262
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0056 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0021 0.0021
Echinococcus multilocularis max protein X 0.05 0.4794 0.4794
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0297 0.1577
Onchocerca volvulus 0.0042 0.0262 0.0243
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.1881 1
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0021 0.0021
Brugia malayi AKH receptor 0.0042 0.0262 0.0262
Giardia lamblia Prenyltransferase 0.0056 0.0404 0.2146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.1677 0.1677
Echinococcus granulosus g protein coupled receptor 0.0042 0.0262 0.0262
Echinococcus multilocularis agrin 0.0019 0.004 0.004
Onchocerca volvulus 0.0042 0.0262 0.0243
Echinococcus multilocularis neuropeptide receptor A26 0.0504 0.4827 0.4827
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0128
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0262 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.031 0.165
Loa Loa (eye worm) hypothetical protein 0.0048 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0072 0.0564 0.0564
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0056 0.0296
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0202 0.1072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0202 0.1072
Brugia malayi Dopamine receptor 0.0042 0.0262 0.0262
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.1881 1
Brugia malayi steroid hormone receptor 0.0017 0.0021 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0048 0.0322 0.0302
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0202 0.1072
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0021 0.0056 0.0296
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0128
Brugia malayi beta-lactamase family protein 0.0072 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0072 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0262 0.0262
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0101 0.0845 0.0845
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0054 0.0285
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0089 0.0089
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0262 0.0262
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0089 0.0089
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0262 0.0262
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0564 0.2102
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0021 0.0056 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0021 0.0021
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.1881 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.004 0.004
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0262 0.0262
Mycobacterium tuberculosis Conserved protein 0.0072 0.0564 0.086
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.2167 0.8611
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0021 0.0056 0.0056
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.1881 0.1881
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0977 0.3641
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0021 0.0056 0.0207
Plasmodium falciparum thioredoxin reductase 0.0036 0.0202 0.1072
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0977 0.0977
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0054 0.0285
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.001 0.001
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0262 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.031 0.165
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0021 0.0021
Onchocerca volvulus 0.0086 0.0701 0.0682
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0202 0.0752
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0262 0.0262
Echinococcus granulosus dna polymerase eta 0.0077 0.0615 0.0615
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.1881 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0056 0.0404 0.1505
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0406 0.1514
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0056 0.0404 0.1505
Echinococcus granulosus somatostatin receptor 0.0042 0.0262 0.0262
Echinococcus multilocularis calpain A 0.0057 0.0415 0.0415
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0202 0.1072
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0108 0.0108
Echinococcus multilocularis allatostatin A receptor 0.0176 0.1594 0.1594
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0021 0.0056 0.0296
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0262 0.0262
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0564 0.086
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0021 0.0021
Schistosoma mansoni biogenic amine receptor 0.0042 0.0262 0.0262
Echinococcus granulosus geminin 0.0346 0.3274 0.3274
Leishmania major hypothetical protein, conserved 0.0072 0.0564 0.2998
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0262 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0262 0.0262
Echinococcus granulosus fmrfamide receptor 0.0042 0.0262 0.0262
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0564 0.2998
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0021 0.0056 0.0056
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0054 0.0285
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.004 0.0213
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0202 0.1072
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0262 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0262 0.0262
Brugia malayi sulfakinin receptor protein 0.0042 0.0262 0.0262
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0406 0.0406
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.001 0.001
Brugia malayi RE15519p 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0072 0.0564 0.0545
Brugia malayi beta-lactamase 0.0072 0.0564 0.0564
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0212 0.0212
Onchocerca volvulus 0.0028 0.0128 0.0109
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0021
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.031 0.031
Schistosoma mansoni amine GPCR 0.0042 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0422 0.4026 0.4026
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0021 0.0021
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.0262 0.0243
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0042 0.0262 0.0243
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Trichomonas vaginalis esterase, putative 0.0072 0.0564 0.2102
Schistosoma mansoni hypothetical protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0977 0.0977
Mycobacterium tuberculosis Conserved protein 0.0072 0.0564 0.086
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0028 0.0128 0.0109
Echinococcus multilocularis expressed protein 0.0019 0.004 0.004
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0021 0.0021
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0021 0.0056 0.0296
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0262 0.0262
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Trypanosoma cruzi MFS transporter, putative 0.0028 0.0128 0.0683
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.004 0.0213
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0977 0.0959
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0262 0.0262
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0101 0.0845 0.0845
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0406 0.216
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0056 0.0404 0.2146
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0101 0.0845 0.0827
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0021 0.0056 0.0296
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0128
Trypanosoma cruzi protein farnesyltransferase, putative 0.0056 0.0404 0.2146
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0202 0.1072
Mycobacterium ulcerans hypothetical protein 0.0072 0.0564 0.2157
Brugia malayi Pre-SET motif family protein 0.0252 0.2341 0.2341
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0564 0.086
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0406 0.0406
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0212 0.0212
Mycobacterium tuberculosis Conserved protein 0.0072 0.0564 0.086
Plasmodium falciparum glutathione reductase 0.0103 0.0866 0.4601
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0872 0.0872
Brugia malayi G protein-coupled receptor 0.0042 0.0262 0.0262
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0054 0.0285
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0202 0.0202
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0262 0.0262
Echinococcus granulosus calpain A 0.0057 0.0415 0.0415
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0202 0.1072
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0277 0.2588 0.2588
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.002 0.002
Toxoplasma gondii hypothetical protein 0.0021 0.0056 0.0296
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi hypothetical protein 0.0028 0.0128 0.0128
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.1677 0.1677
Schistosoma mansoni amine GPCR 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0028 0.0128 0.0109
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0021 0.0021
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0387 0.0387
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.031 0.1157
Brugia malayi Trypsin family protein 0.0101 0.0845 0.0845
Schistosoma mansoni biogenic amine receptor 0.0042 0.0262 0.0262
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0202 0.1072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0262 0.0262
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0262 0.0262
Trypanosoma brucei unspecified product 0.0032 0.0167 0.089
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0564 0.086
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0167 0.089
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.031 0.031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0021 0.0021
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0021 0.0021
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0322 0.0322
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0977 0.0977
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.001 0.001
Echinococcus granulosus orexin receptor type 2 0.0042 0.0262 0.0262
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0021 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.004
Onchocerca volvulus 0.0021 0.0056 0.0036
Brugia malayi nuclear hormone receptor 0.0017 0.0021 0.0021
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0021 0.0021
Brugia malayi Melatonin receptor type 1A 0.0042 0.0262 0.0262
Echinococcus multilocularis dna polymerase eta 0.0077 0.0615 0.0615
Toxoplasma gondii transporter, major facilitator family protein 0.0028 0.0128 0.0683
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.05 0.4794 0.4794
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0262 0.0262
Plasmodium falciparum cysteine repeat modular protein 1 0.0017 0.002 0.0106
Onchocerca volvulus 0.0042 0.0262 0.0243
Plasmodium vivax SET domain protein, putative 0.0037 0.0212 0.1129
Onchocerca volvulus 0.0042 0.0262 0.0243
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0056 0.0404 0.0404
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0054 0.0285
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0262 0.0262
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0128 0.0128
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0021 0.0021
Brugia malayi hypothetical protein 0.0042 0.0262 0.0262
Schistosoma mansoni opsin-like receptor 0.0042 0.0262 0.0262
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0021 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.1881 1
Echinococcus granulosus tm gpcr rhodopsin 0.0565 0.5437 0.5437
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0406 0.0486
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.031 0.165
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0262 0.0262
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0021 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0564 0.0564
Brugia malayi larval opioid receptor 0.0042 0.0262 0.0262
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0262 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0072 0.0564 0.0545
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0021
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0262 0.0262
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0262 0.0262
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0028 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Mycobacterium ulcerans lipase LipD 0.0072 0.0564 0.2157
Brugia malayi Dopamine receptor protein 2 0.0042 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0042 0.0262 0.0262
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0021 0.0021
Leishmania major DNA polymerase eta, putative 0.0077 0.0615 0.3266
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.1881 1
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.1881 1
Toxoplasma gondii thioredoxin reductase 0.0103 0.0866 0.4601
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0564 0.086
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0262 0.0262
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.031 0.1157
Echinococcus granulosus calpain 5 0.0021 0.0054 0.0054
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.2426 0.528
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.1822 0.1822
Plasmodium vivax calpain, putative 0.0021 0.0054 0.0285
Schistosoma mansoni organic anion transporter 0.0028 0.0128 0.0128
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0595 0.3165
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.1677 0.1677
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0564 0.2102
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0866 0.1576
Leishmania major farnesyltransferase beta subunit 0.0056 0.0404 0.2146
Brugia malayi SPARC precursor 0.0019 0.004 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.031 0.165
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0021 0.0021
Echinococcus granulosus g protein coupled receptor 0.0042 0.0262 0.0262
Treponema pallidum phosphoglycerate kinase 0.0206 0.1881 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.004 0.004
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0262 0.0262
Schistosoma mansoni bhlhzip transcription factor bigmax 0.05 0.4794 0.4794
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0387 0.0387
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0021 0.0021
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.1822 0.1822
Schistosoma mansoni hypothetical protein 0.0346 0.3274 0.3274
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.1881 1
Trypanosoma brucei unspecified product 0.0047 0.031 0.165
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0977 0.3641
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.031 0.165
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0054 0.0285
Brugia malayi Thioredoxin reductase 0.0103 0.0866 0.0866
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0021 0.0021
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0054 0.0285
Giardia lamblia DINP protein human, muc B family 0.0047 0.031 0.165
Loa Loa (eye worm) hypothetical protein 0.0035 0.0197 0.0197
Schistosoma mansoni follistatin 0.0019 0.004 0.004
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0037 0.0212 0.0212
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0977 0.5195
Loa Loa (eye worm) calpain family protein 1 0.0055 0.039 0.039
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0202 0.1072
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0021 0.0056 0.0056
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.1881 1
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0564 0.2102
Loa Loa (eye worm) calpain 0.0021 0.0054 0.0054
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0564 0.2998
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0021 0.0056 0.0056
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0262 0.0262
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0564 0.2157
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.031 0.031
Onchocerca volvulus 0.0072 0.0564 0.0545
Schistosoma mansoni ap endonuclease 0.0056 0.0406 0.0406
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0143 0.0143
Toxoplasma gondii exonuclease III APE 0.0056 0.0406 0.216
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0021 0.0021
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.1881 0.701
Trypanosoma brucei antigen, putative 0.0021 0.0054 0.0285
Onchocerca volvulus Cell death protein 3 homolog 0.0308 0.2889 0.2875
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0202 0.0202
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0322 0.0322
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0202 0.1072
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.0595 0.3165
Loa Loa (eye worm) hypothetical protein 0.0034 0.0186 0.0186
Schistosoma mansoni biogenic amine receptor 0.0042 0.0262 0.0262
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0021 0.0021
Brugia malayi hypothetical protein 0.0042 0.0262 0.0262
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0128 0.0109
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0021 0.0056 0.0056
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0017 0.002 0.0106
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.004
Brugia malayi hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi Serotonin receptor 0.0042 0.0262 0.0262
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0418 0.2223
Brugia malayi Dopamine receptor protein 1 0.0042 0.0262 0.0262
Echinococcus multilocularis hypothetical protein 0.0021 0.0054 0.0054
Echinococcus granulosus max protein X 0.05 0.4794 0.4794
Brugia malayi G-protein coupled receptor 0.0042 0.0262 0.0262
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0564 0.086
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0297 0.1577
Giardia lamblia Rab geranylgeranyltransferase 0.0021 0.0056 0.0296
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0615 0.3266
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0056 0.0404 0.2146
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0202 0.1072
Brugia malayi Protein kinase domain containing protein 0.0017 0.002 0.002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0042 0.0262 0.0243
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.1677 0.1677
Schistosoma mansoni kinase 0.0058 0.0423 0.0423
Mycobacterium ulcerans beta-lactamase 0.0072 0.0564 0.2157
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0406 0.216
Loa Loa (eye worm) hypothetical protein 0.0308 0.2889 0.2889
Echinococcus granulosus neuropeptide receptor 0.0042 0.0262 0.0262
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0054 0.0054
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.004 0.004
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.2167 0.4666
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.004 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0034 0.0186 0.0167
Toxoplasma gondii protease inhibitor PI2 0.0019 0.004 0.0213
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0054 0.0285
Brugia malayi follicle stimulating hormone receptor 0.0042 0.0262 0.0262
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0042 0.0262 0.0243
Onchocerca volvulus 0.0028 0.0128 0.0109
Echinococcus multilocularis apoptotic protease activating factor 1 0.0308 0.2889 0.2889
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0054 0.0285
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0017 0.002 0.002
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0028 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi Phosphoglycerate kinase 0.0206 0.1881 0.1881
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0977 0.3641
Leishmania major lanosterol synthase, putative 0.0046 0.0307 0.1634
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.004
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0202 0.0202
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0193 0.0193
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0021 0.0056 0.0207
Trypanosoma brucei trypanothione reductase 0.0103 0.0866 0.4601
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0565 0.5437 0.5437
Brugia malayi hypothetical protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0021 0.0021
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.7692 0.7692
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0408 0.152
Brugia malayi nuclear receptor NHR-88 0.0017 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0042 0.0262 0.0243
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0202 0.1072
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Brugia malayi hypothetical protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0262 0.0262
Echinococcus multilocularis dna polymerase kappa 0.0047 0.031 0.031
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.004 0.0248 0.0248
Echinococcus multilocularis follistatin 0.0019 0.004 0.004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0262 0.0262
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.1881 0.7075
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Schistosoma mansoni neuropeptide receptor 0.0042 0.0262 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.031 0.165
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0977 0.5195
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.1881 1
Schistosoma mansoni hypothetical protein 0.0346 0.3274 0.3274
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0322 0.0322
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0977 0.0977
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0128
Onchocerca volvulus 0.0037 0.0212 0.0193
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0564 0.0564
Brugia malayi hypothetical protein 0.0308 0.2889 0.2889
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0041 0.0253 0.1347
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0357 0.0357
Brugia malayi mbt repeat family protein 0.0048 0.0322 0.0322
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0262 0.0262
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0021 0.0056 0.0296
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0262 0.0262
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.004 0.0213
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0128 0.0109
Onchocerca volvulus 0.0042 0.0262 0.0243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0262 0.0262
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0128 0.0109
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0262 0.0262
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0262 0.0262
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0021 0.0056 0.0296
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0021 0.0056 0.0296
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0262 0.0262
Echinococcus granulosus serotonin receptor 0.0042 0.0262 0.0262
Schistosoma mansoni myosin xvIII 0.0042 0.0262 0.0262
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0406 0.216
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0262 0.0262
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0021 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0021 0.0021
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0021
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0067 0.0516 0.0516
Brugia malayi Pre-SET motif family protein 0.0037 0.0212 0.0212
Schistosoma mansoni calpain (C02 family) 0.0021 0.0054 0.0054
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0262 0.0262
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0035 0.0197 0.0197
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.1881 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0021 0.0001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0202 0.1072
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0202 0.0202
Schistosoma mansoni hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0021 0.0021
Brugia malayi glutathione reductase 0.0103 0.0866 0.0866
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1677 0.1677
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0021 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.1677 0.1677
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0977 0.3641
Schistosoma mansoni caspase-7 (C14 family) 0.0308 0.2889 0.2889
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.031 0.0647
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.2426 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0262 0.0262
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0406 0.216
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0202 0.1072
Schistosoma mansoni adenoreceptor 0.0042 0.0262 0.0262
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0128
Brugia malayi hypothetical protein 0.0028 0.0128 0.0128
Brugia malayi Kringle domain containing protein 0.0017 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.004
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0564 0.0564
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0406 0.0406
Onchocerca volvulus 0.0042 0.0262 0.0243
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.05 0.4794 0.4794
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0056 0.0404 0.2146
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi neuropeptide F receptor 0.0042 0.0262 0.0262
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.031 0.165
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0028 0.0128 0.0128
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0357 0.0357
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0056 0.0404 0.1505
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.2167 0.4666
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0028 0.0128 0.0109
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8087 0.8087
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.1881 1
Plasmodium falciparum glutathione reductase 0.0036 0.0202 0.1072
Brugia malayi hypothetical protein 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Echinococcus granulosus sex peptide receptor 0.0042 0.0262 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0021 0.0021
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0977 0.5195
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0872 0.0872
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.0262 0.0243
Echinococcus multilocularis somatostatin receptor 0.0042 0.0262 0.0262
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.031 0.165
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0322 0.0322
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0202 0.1072
Echinococcus multilocularis calpain 0.0021 0.0054 0.0054
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.039 0.039
Brugia malayi neuropeptide F receptor 0.0042 0.0262 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0021 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0977 0.3641
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.4026 0.4026
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0406 0.1218
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.2426 0.528
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Schistosoma mansoni bhlhzip transcription factor bigmax 0.05 0.4794 0.4794
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0262 0.0262
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0054 0.0285
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0054 0.0285
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0277 0.2588 0.2588
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0021 0.0021
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.1881 0.701
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.031 0.0258
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0595 0.3165
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.1881 1
Echinococcus granulosus agrin 0.0019 0.004 0.004
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0056 0.0404 0.1505
Schistosoma mansoni coup transcription factor 0.0017 0.0021 0.0021
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0054 0.0285
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0415 0.0415
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0564 0.2102
Brugia malayi Latrophilin receptor protein 2 0.0016 0.001 0.001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0406 0.0406
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0262 0.0262
Schistosoma mansoni opsin-like receptor 0.0042 0.0262 0.0262
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0977 0.3641
Brugia malayi hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi beta-lactamase family protein 0.0072 0.0564 0.0564
Plasmodium falciparum thioredoxin reductase 0.0103 0.0866 0.4601
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0054 0.0285
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0262 0.0262
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0277 0.2588 0.2588
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0415 0.0415
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.031 0.031
Schistosoma mansoni ap endonuclease 0.0056 0.0406 0.0406
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0564 0.2157
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0322 0.0302
Brugia malayi hypothetical protein 0.0042 0.0262 0.0262
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0021 0.0021
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0977 0.0977
Trichomonas vaginalis set domain proteins, putative 0.0287 0.2684 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0845 0.0845
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0262 0.0262
Onchocerca volvulus 0.0042 0.0262 0.0243
Echinococcus multilocularis GPCR, family 2 0.0016 0.001 0.001
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0128 0.0128
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0176 0.1594 0.1594
Echinococcus multilocularis neuropeptide s receptor 0.0504 0.4827 0.4827
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.4414 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0021 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1677 0.1677
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.1881 0.1881
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0021 0.0021
Echinococcus multilocularis calpain family protein 1, d 0.004 0.0248 0.0248
Toxoplasma gondii ABC1 family protein 0.0072 0.0564 0.2998
Loa Loa (eye worm) hypothetical protein 0.0048 0.0329 0.0329
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0977 0.3641
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.002 0.002
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0056 0.0404 0.0404
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0212 0.0212
Brugia malayi ORL1-like opioid receptor 0.0042 0.0262 0.0262
Echinococcus multilocularis geminin 0.0346 0.3274 0.3274
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0408 0.152
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0021 0.0056 0.0056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.031 0.165
Brugia malayi calpain 7 0.0021 0.0054 0.0054
Echinococcus multilocularis sex peptide receptor 0.0042 0.0262 0.0262
Brugia malayi G-protein coupled receptor 0.0042 0.0262 0.0262
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8087 0.8087
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0021 0.0021
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0262 0.0262
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.1881 0.3987
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0564 0.0564
Brugia malayi prostaglandin transporter 0.0028 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0262 0.0262
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2341 0.2341
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0021 0.0021
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0262 0.0262
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0202 0.1072
Echinococcus granulosus neuropeptide s receptor 0.0504 0.4827 0.4827
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0021 0.0021
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0056 0.0404 0.0404
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.004 0.004
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0387 0.0387
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0262 0.0262
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0054 0.0285
Schistosoma mansoni hypothetical protein 0.0308 0.2889 0.2889
Trypanosoma brucei unspecified product 0.0032 0.0167 0.089
Schistosoma mansoni cpg binding protein 0.0031 0.016 0.016
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.031 0.165
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0021 0.0021
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0262
Echinococcus granulosus GPCR family 2 0.0016 0.001 0.001
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0021 0.0021
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0108 0.0108
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0866 0.4601
Schistosoma mansoni histamine h1 receptor 0.0042 0.0262 0.0262
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0057 0.0415 0.0415
Schistosoma mansoni hypothetical protein 0.0052 0.0359 0.0359
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0021 0.0056 0.0296
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0056 0.0404 0.1505
Schistosoma mansoni amine GPCR 0.0042 0.0262 0.0262
Loa Loa (eye worm) beta-lactamase 0.0072 0.0564 0.0564

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 33.149 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of Mex-5 Binding to TCR-2. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
EC50 (binding) = 91.471 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of POS-1 Binding to mex-3-RNA. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
IC50 (functional) 13.025 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.6513 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.9173 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 22.3342 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) - Round 2 Cherry Picks. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2367, AID593, AID594] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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