TDR Targets

Basic information

Technical information

TDR Targets ID: 1405713
Name: 2-(methylthio)-5-[2-(methylthio)pyrimidin-4-y l]-4-phenylthiophene-3-carbonitrile
MW: 355.5 | Formula: C17H13N3S3
H donors: 0 H acceptors: 3 LogP: 4.62 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CSc1sc(c(c1C#N)c1ccccc1)c1ccnc(n1)SC
InChi: 1S/C17H13N3S3/c1-21-16-12(10-18)14(11-6-4-3-5-7-11)15(23-16)13-8-9-19-17(20-13)22-2/h3-9H,1-2H3
InChiKey: JTVSXHPMYXGZOJ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

MLS000860726
SMR000459510
ZINC01038631

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	l(3)mbt-like 1 (Drosophila)	Starlite/ChEMBL	No references
Homo sapiens	neuropeptide S receptor 1	Starlite/ChEMBL	No references
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	No references
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 3 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus granulosus	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 4 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130415	All targets in OG5_130415
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus multilocularis	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.1145	0.4768	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0035	0.0073
Echinococcus granulosus	neural cadherin	0.0219	0.0882	0.1588
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0058	0.0203	0.0355
Echinococcus multilocularis	polycomb protein SCMH1	0.0058	0.0203	0.0203
Brugia malayi	EGF-like domain containing protein	0.0219	0.0882	0.1851
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0025	0.0067	0.0121
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0203	0.0365
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0066	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0035	0.0073
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0045	0.0151	1
Toxoplasma gondii	exonuclease III APE	0.0018	0.0037	0.011
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0061	0.0218	0.0392
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0058	0.0203	0.0203
Loa Loa (eye worm)	oxidoreductase	0.008	0.0296	0.062
Brugia malayi	Pre-SET motif family protein	0.0037	0.0115	0.0241
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0219	0.1684
Echinococcus multilocularis	slit 2 protein	0.0219	0.0882	0.0882
Loa Loa (eye worm)	oxidoreductase	0.008	0.0296	0.062
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0343	0.0617
Onchocerca volvulus		0.0287	0.1164	0.2386
Brugia malayi	mbt repeat family protein	0.0058	0.0203	0.0425
Brugia malayi	hypothetical protein	0.1145	0.4768	1
Echinococcus granulosus	fibropellin Ia	0.0219	0.0882	0.1588
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0052	0.0181	0.038
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0035	0.0073
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0018	0.0035	0.0063
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.008	0.0296	0.2357
Schistosoma mansoni	slit	0.0219	0.0882	0.1588
Onchocerca volvulus	Peroxidasin homolog	0.1145	0.4768	1
Onchocerca volvulus	Slit protein homolog	0.0219	0.0882	0.1791
Loa Loa (eye worm)	animal heme peroxidase	0.1145	0.4768	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.0401	0.313
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0154	0.0323
Echinococcus multilocularis	aldo keto reductase	0.008	0.0296	0.0296
Mycobacterium tuberculosis	Conserved protein	0.008	0.0296	0.2245
Brugia malayi	glutathione reductase	0.0046	0.0154	0.0323
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0061	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Schistosoma mansoni	hypothetical protein	0.0079	0.0294	0.0528
Entamoeba histolytica	hypothetical protein	0.0037	0.0115	0.2992
Schistosoma mansoni	ap endonuclease	0.0018	0.0037	0.0067
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0219	0.0882	0.0882
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Brugia malayi	Animal haem peroxidase family protein	0.1145	0.4768	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0214	0.0384
Plasmodium vivax	SET domain protein, putative	0.0037	0.0115	0.3249
Schistosoma mansoni	microsomal glutathione s-transferase	0.0118	0.0457	0.0821
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.008	0.0296	0.2357
Brugia malayi	hypothetical protein	0.0037	0.0115	0.024
Onchocerca volvulus		0.0161	0.0635	0.1269
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0343	0.0617
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0018	0.0035	0.0063
Plasmodium vivax	multidomain scavenger receptor, putative	0.0079	0.0294	0.9922
Echinococcus granulosus	neurogenic locus notch protein	0.0219	0.0882	0.1588
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0037	0.0078
Loa Loa (eye worm)	inositol-1	0.0036	0.0112	0.0234
Loa Loa (eye worm)	oxidoreductase	0.008	0.0296	0.062
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0181	0.038
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.008	0.0296	0.3134
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0219	0.1605
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.008	0.0296	0.0532
Onchocerca volvulus	Peroxidase homolog	0.1145	0.4768	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.008	0.0296	0.0296
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.045	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0018	0.0035	0.0035
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0219	0.1684
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.03	0.1221	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0018	0.0035	0.0063
Echinococcus multilocularis	aldo keto reductase	0.008	0.0296	0.0296
Giardia lamblia	Aldose reductase	0.008	0.0296	0.3134
Schistosoma mansoni	hypothetical protein	0.0354	0.1446	0.2602
Echinococcus granulosus	peroxidasin	0.1145	0.4768	0.8578
Echinococcus granulosus	neurogenic locus protein delta	0.0219	0.0882	0.1588
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0045	0.0151	0.1437
Trypanosoma cruzi	aldo/keto reductase, putative	0.008	0.0296	0.2245
Echinococcus multilocularis	ecdysone induced protein 78C	0.0018	0.0035	0.0035
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0037	0.0115	0.1018
Brugia malayi	Doublecortin family protein	0.0079	0.0294	0.0616
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0028	0.005
Echinococcus granulosus	aldo keto reductase	0.008	0.0296	0.0532
Echinococcus multilocularis	muscleblind protein	0.018	0.0718	0.0718
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Schistosoma mansoni	ap endonuclease	0.0018	0.0037	0.0067
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0018	0.0035	0.0073
Leishmania major	aldo-keto reductase-like protein	0.008	0.0296	0.2245
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.008	0.0296	0.0532
Echinococcus multilocularis	neuropeptide receptor A26	0.0899	0.3736	0.3736
Mycobacterium leprae	conserved hypothetical protein	0.0045	0.0151	0.1544
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0343	0.0617
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0112	0.0201
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0343	0.0617
Mycobacterium tuberculosis	Probable oxidoreductase	0.008	0.0296	0.2245
Brugia malayi	EGF-like domain containing protein	0.0219	0.0882	0.1851
Echinococcus multilocularis	FTZ F1 alpha	0.0018	0.0035	0.0035
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.008	0.0296	0.0296
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0037	0.0079
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0079	0.0294	0.0294
Echinococcus granulosus	polycomb protein SCMH1	0.0058	0.0203	0.0365
Loa Loa (eye worm)	blistered cuticle protein 3	0.1145	0.4768	1
Echinococcus granulosus	L aminoadipate semialdehyde	0.0161	0.0635	0.1143
Echinococcus granulosus	microtubule associated protein 2	0.1333	0.5558	1
Onchocerca volvulus		0.008	0.0296	0.0551
Echinococcus multilocularis	Polycystic kidney disease protein	0.0079	0.0294	0.0294
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0037	0.0115	0.0207
Schistosoma mansoni	hypothetical protein	0.0219	0.0882	0.1588
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0154	0.4708
Trypanosoma brucei	aldo-keto reductase, putative	0.008	0.0296	0.2245
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.0035	0.0073
Brugia malayi	Thioredoxin reductase	0.0046	0.0154	0.0323
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.008	0.0296	0.0296
Onchocerca volvulus		0.008	0.0296	0.0551
Mycobacterium ulcerans	oxidoreductase	0.008	0.0296	0.2245
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.008	0.0296	0.2357
Trypanosoma cruzi	aldo-keto reductase	0.008	0.0296	0.2245
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.008	0.0296	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0063	0.0133
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0045	0.0151	0.4585
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.008	0.0296	0.0532
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0018	0.0035	0.0063
Schistosoma mansoni	lipoxygenase	0.0474	0.1951	0.3509
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0037	0.0079
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0037	0.0078
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.008	0.0296	0.0532
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0045	0.0151	0.103
Echinococcus granulosus	neurogenic locus notch protein 4	0.0219	0.0882	0.1588
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0219	0.0882	0.0882
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0003	0.0005
Schistosoma mansoni	hypothetical protein	0.0205	0.082	0.1475
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0066	0.0236	0.0236
Schistosoma mansoni	lipoxygenase	0.0331	0.1352	0.2432
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0035	0.0073
Echinococcus multilocularis	muscleblind protein 1	0.018	0.0718	0.0718
Echinococcus multilocularis	neurogenic locus protein delta	0.0219	0.0882	0.0882
Echinococcus multilocularis	neurogenic locus notch protein	0.0219	0.0882	0.0882
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0219	0.0395
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Loa Loa (eye worm)	doublecortin family protein	0.0079	0.0294	0.0616
Schistosoma mansoni	nuclear hormone receptor	0.0018	0.0035	0.0063
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.008	0.0296	0.062
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.0035	0.0035
Mycobacterium ulcerans	hypothetical protein	0.008	0.0296	0.2245
Loa Loa (eye worm)	steroid hormone receptor	0.0018	0.0035	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0037	0.0115	0.0115
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0018	0.0035	0.0063
Leishmania major	prostaglandin f synthase, putative	0.008	0.0296	0.2245
Brugia malayi	Peroxidasin	0.1145	0.4768	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0018	0.0035	0.0073
Onchocerca volvulus		0.1145	0.4768	1
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Schistosoma mansoni	hypothetical protein	0.0219	0.0882	0.1588
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0077	0.0162
Brugia malayi	Inositol-1	0.0036	0.0112	0.0234
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Echinococcus multilocularis	notch	0.0219	0.0882	0.0882
Schistosoma mansoni	cpg binding protein	0.0028	0.0077	0.0139
Brugia malayi	mbt repeat family protein	0.0058	0.0203	0.0425
Echinococcus multilocularis	musashi	0.0052	0.0181	0.0181
Trichomonas vaginalis	aldo/keto reductase, putative	0.008	0.0296	0.2357
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0037	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Brugia malayi	ecdysteroid receptor	0.0018	0.0035	0.0073
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0194	0.0774	0.1622
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Echinococcus granulosus	slit 2 protein	0.0219	0.0882	0.1588
Loa Loa (eye worm)	MBCTL1	0.0066	0.0236	0.0496
Onchocerca volvulus	Phospholipase A2 homolog	0.0093	0.035	0.0666
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.0401	0.313
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.008	0.0296	0.2357
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0018	0.0035	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Brugia malayi	cytoplasmic intermediate filament protein	0.0028	0.0079	0.0166
Echinococcus multilocularis	neuropeptide s receptor	0.0899	0.3736	0.3736
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.008	0.0296	0.062
Brugia malayi	Muscleblind-like protein	0.018	0.0718	0.1506
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0018	0.0035	0.0073
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0112	0.0703
Loa Loa (eye worm)	animal heme peroxidase	0.1145	0.4768	1
Onchocerca volvulus	Peroxidasin homolog	0.1145	0.4768	1
Brugia malayi	hypothetical protein	0.0079	0.0294	0.0616
Schistosoma mansoni	cpg binding protein	0.0029	0.0084	0.0151
Echinococcus multilocularis	fibropellin Ia	0.0219	0.0882	0.0882
Brugia malayi	NADH-dependent xylose reductase	0.008	0.0296	0.062
Echinococcus granulosus	histone acetyltransferase MYST2	0.0066	0.0236	0.0425
Schistosoma mansoni	RAR-like nuclear receptor	0.0018	0.0035	0.0063
Entamoeba histolytica	hypothetical protein	0.0037	0.0115	0.2992
Echinococcus multilocularis	lamin dm0	0.0052	0.0181	0.0181
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0077	0.0162
Schistosoma mansoni	hypothetical protein	0.0061	0.0218	0.0392
Echinococcus multilocularis	protein jagged 1	0.0219	0.0882	0.0882
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0112	0.0703
Schistosoma mansoni	loxhd1	0.0079	0.0294	0.0528
Schistosoma mansoni	cpg binding protein	0.0029	0.0084	0.0151
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0194	0.0774	0.1622
Brugia malayi	Muscle positioning protein 4	0.0219	0.0882	0.1851
Entamoeba histolytica	aldose reductase, putative	0.008	0.0296	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0115	0.0115
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0112	0.0981
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0018	0.0035	0.0063
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0219	0.1605
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0035	0.0073
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0025	0.0067	0.0067
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0045	0.0151	0.103
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0066	0.0236	0.0425
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0096	0.0571
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0061	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.008	0.0296	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0112	0.0703
Loa Loa (eye worm)	intermediate filament protein	0.0052	0.0181	0.038
Plasmodium falciparum	LCCL domain-containing protein	0.0079	0.0294	0.9922
Onchocerca volvulus		0.0219	0.0882	0.1791
Onchocerca volvulus		0.1145	0.4768	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0037	0.0079
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.0401	0.313
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Echinococcus granulosus	neurogenic locus notch protein	0.0219	0.0882	0.1588
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Brugia malayi	EGF-like domain containing protein	0.0219	0.0882	0.1851
Loa Loa (eye worm)	hypothetical protein	0.0093	0.035	0.0735
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0035	0.0073
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0018	0.0035	0.0073
Trichomonas vaginalis	set domain proteins, putative	0.0287	0.1164	1
Onchocerca volvulus		0.0219	0.0882	0.1791
Schistosoma mansoni	microtubule-associated protein tau	0.1333	0.5558	1
Brugia malayi	notch-like transmembrane receptor	0.0219	0.0882	0.1851
Echinococcus multilocularis	protein jagged 2	0.0219	0.0882	0.0882
Onchocerca volvulus	Dual oxidase homolog	0.1145	0.4768	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0112	0.0738
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0161	0.0635	0.1143
Schistosoma mansoni	hypothetical protein	0.0061	0.0218	0.0392
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0343	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0774	0.1622
Loa Loa (eye worm)	animal heme peroxidase	0.1145	0.4768	1
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0045	0.0151	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0112	0.6829
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0037	0.011
Echinococcus multilocularis	neurogenic locus protein delta	0.0219	0.0882	0.0882
Echinococcus granulosus	intermediate filament protein	0.0052	0.0181	0.0326
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0154	0.0154
Trichomonas vaginalis	aldo/keto reductase, putative	0.008	0.0296	0.2357
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0045	0.0151	1
Onchocerca volvulus	Phospholipase A2 homolog	0.0093	0.035	0.0666
Echinococcus multilocularis	peroxidasin	0.1145	0.4768	0.4768
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.008	0.0296	0.0296
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0474	0.1951	0.1951
Brugia malayi	intermediate filament protein	0.0052	0.0181	0.038
Trypanosoma brucei	trypanothione reductase	0.0046	0.0154	0.1057
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.008	0.0296	0.0296
Giardia lamblia	High cysteine protein	0.0219	0.0882	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0037	0.0079
Loa Loa (eye worm)	oxidoreductase	0.008	0.0296	0.062
Schistosoma mansoni	notch	0.0219	0.0882	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0236	0.0496
Schistosoma mansoni	notch	0.0219	0.0882	0.1588
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0037	0.0067
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.008	0.0296	0.0532
Brugia malayi	Cadherin domain containing protein	0.0219	0.0882	0.1851
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.008	0.0296	0.0532
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0018	0.0035	0.0073
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.008	0.0296	0.062
Plasmodium vivax	aldehyde reductase, putative	0.008	0.0296	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0018	0.0035	0.0063
Entamoeba histolytica	alcohol dehydrogenase, putative	0.008	0.0296	1
Schistosoma mansoni	pol-related	0.008	0.0296	0.0532
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0115	0.0206
Loa Loa (eye worm)	animal heme peroxidase	0.1145	0.4768	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.0035	0.0073
Echinococcus multilocularis	protein jagged 1	0.0219	0.0882	0.0882
Echinococcus granulosus	aldo keto reductase	0.008	0.0296	0.0532
Schistosoma mansoni	hypothetical protein	0.0061	0.0218	0.0392
Echinococcus granulosus	ecdysone induced protein 78C	0.0018	0.0035	0.0063
Toxoplasma gondii	aldo-keto reductase	0.008	0.0296	0.3134
Entamoeba histolytica	hypothetical protein	0.0037	0.0115	0.2992
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Trichomonas vaginalis	conserved hypothetical protein	0.008	0.0296	0.2357
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0018	0.0035	0.0073
Brugia malayi	Animal haem peroxidase family protein	0.1145	0.4768	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0079	0.0294	0.0294
Schistosoma mansoni	retinoic acid receptor RXR	0.0018	0.0035	0.0063
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0018	0.0035	0.0035
Schistosoma mansoni	lamin	0.0052	0.0181	0.0326
Echinococcus granulosus	protein jagged 2	0.0219	0.0882	0.1588
Echinococcus granulosus	protein jagged 2	0.0219	0.0882	0.1588
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0252	0.1019	0.2136
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Echinococcus multilocularis	neurogenic locus notch protein	0.0219	0.0882	0.0882
Toxoplasma gondii	aldose reductase, putative	0.008	0.0296	0.3134
Schistosoma mansoni	notch	0.0219	0.0882	0.1588
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0115	0.0207
Brugia malayi	Calcium binding EGF domain containing protein	0.0219	0.0882	0.1851
Onchocerca volvulus		0.0219	0.0882	0.1791
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.0219	0.224
Trichomonas vaginalis	aldo/keto reductase, putative	0.008	0.0296	0.2357
Echinococcus granulosus	neuropeptide receptor A26	0.0899	0.3736	0.6721
Onchocerca volvulus		0.0028	0.0077	0.009
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0045	0.0151	0.4585
Echinococcus granulosus	delta-like protein 1	0.0219	0.0882	0.1588
Schistosoma mansoni	rab6-interacting	0.0079	0.0294	0.0528
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.0035	0.0073
Plasmodium falciparum	aldo-keto reductase, putative	0.008	0.0296	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0045	0.0151	0.1437
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0154	0.4708
Echinococcus granulosus	SAM and MBT domain containing protein	0.0058	0.0203	0.0365
Onchocerca volvulus		0.0219	0.0882	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0115	0.0206
Leishmania major	trypanothione reductase	0.0046	0.0154	0.1057
Brugia malayi	EGF-like domain containing protein	0.0219	0.0882	0.1851
Trypanosoma cruzi	aldo/keto reductase, putative	0.008	0.0296	0.2245
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Trypanosoma brucei	aldo/keto reductase, putative	0.008	0.0296	0.2245
Onchocerca volvulus		0.008	0.0296	0.0551
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0028	0.0058
Entamoeba histolytica	aldose reductase, putative	0.008	0.0296	1
Mycobacterium tuberculosis	Probable reductase	0.0105	0.0401	0.313
Echinococcus granulosus	muscleblind protein	0.018	0.0718	0.1292
Schistosoma mansoni	hypothetical protein	0.0132	0.0516	0.0929
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0037	0.0037
Giardia lamblia	Aldose reductase	0.008	0.0296	0.3134
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.0343	0.0719
Brugia malayi	Latrophilin receptor protein 2	0.0061	0.0218	0.0457
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0219	0.046
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0219	0.1605
Echinococcus granulosus	voltage gated potassium channel subunit	0.008	0.0296	0.0532
Echinococcus granulosus	Polycystic kidney disease protein	0.0079	0.0294	0.0528
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.001	0.0021
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Echinococcus multilocularis	voltage gated potassium channel subunit	0.008	0.0296	0.0296
Onchocerca volvulus		0.0219	0.0882	0.1791
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0194	0.0774	0.1622
Schistosoma mansoni	hypothetical protein	0.0219	0.0882	0.1588
Onchocerca volvulus		0.0079	0.0294	0.0547
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.0035	0.0073
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0058	0.0203	0.0365
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.045	0.3542
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0112	0.2881
Echinococcus granulosus	RUN	0.0079	0.0294	0.0528
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0112	0.0703
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0219	0.1684
Entamoeba histolytica	hypothetical protein	0.0045	0.0151	0.4388
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.008	0.0296	0.0296
Onchocerca volvulus		0.0037	0.0115	0.0169
Echinococcus multilocularis	cpg binding protein	0.0029	0.0084	0.0084
Echinococcus granulosus	neuropeptide s receptor	0.0899	0.3736	0.6721
Brugia malayi	Calcium binding EGF domain containing protein	0.0219	0.0882	0.1851
Schistosoma mansoni	notch	0.0219	0.0882	0.1588
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0018	0.0035	0.0063
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Schistosoma mansoni	hypothetical protein	0.0037	0.0115	0.0206
Schistosoma mansoni	hypothetical protein	0.0219	0.0882	0.1588
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.008	0.0296	0.5637
Echinococcus multilocularis	RUN	0.0079	0.0294	0.0294
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.0118	0.0457	0.0457
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.045	0.3542
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.03	0.1221	1
Echinococcus granulosus	microsomal glutathione S transferase 3	0.0118	0.0457	0.0821
Echinococcus granulosus	cpg binding protein	0.0029	0.0084	0.0151
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.008	0.0296	0.0296
Entamoeba histolytica	alcohol dehydrogenase, putative	0.008	0.0296	1
Echinococcus granulosus	lamin	0.0052	0.0181	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0219	0.1605
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0112	0.0703
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0115	0.0207
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Onchocerca volvulus		0.008	0.0296	0.0551
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0154	0.0277
Plasmodium falciparum	glutathione reductase	0.0046	0.0154	0.4708
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.0035	0.0063
Onchocerca volvulus	Peroxidase homolog	0.1145	0.4768	1
Echinococcus multilocularis	lamin	0.0052	0.0181	0.0181
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0002	0.0005
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.0401	0.313
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0219	0.0882	0.1791
Echinococcus granulosus	hypothetical protein	0.008	0.0296	0.0532
Echinococcus granulosus	FTZ F1 alpha	0.0018	0.0035	0.0063
Schistosoma mansoni	hypothetical protein	0.0205	0.082	0.1475
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0037	0.0083
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0037	0.0083
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0154	0.1057
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.008	0.0296	0.062
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0037	0.0766
Brugia malayi	Pre-SET motif family protein	0.0252	0.1019	0.2136
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0219	0.1605
Loa Loa (eye worm)	notch protein	0.0219	0.0882	0.1851
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0294	0.0616
Brugia malayi	GCC2 and GCC3 family protein	0.0219	0.0882	0.1851
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.008	0.0296	0.2245
Brugia malayi	photoreceptor-specific nuclear receptor	0.0018	0.0035	0.0073
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.008	0.0296	0.0296
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0061	0.0218	0.0392
Onchocerca volvulus		0.0052	0.0181	0.0309
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0219	0.0882	0.1851
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0219	0.1684
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0107	0.0192
Brugia malayi	Calcium binding EGF domain containing protein	0.0219	0.0882	0.1851
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0343	0.0343
Brugia malayi	Animal haem peroxidase family protein	0.1145	0.4768	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0294	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Echinococcus granulosus	protein jagged 1	0.0219	0.0882	0.1588
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0066	0.0236	0.0496
Schistosoma mansoni	lamin	0.0052	0.0181	0.0326
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.008	0.0296	0.0532
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.0035	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Brugia malayi	latrophilin 2 splice variant baaae	0.0132	0.0516	0.1083
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Loa Loa (eye worm)	mbt repeat family protein	0.0058	0.0203	0.0425
Onchocerca volvulus	Neurogenic locus notch homolog	0.0219	0.0882	0.1791
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0219	0.224
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0035	0.0073
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0018	0.0035	0.0073
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0219	0.0395
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0112	0.0201
Onchocerca volvulus	Chorion peroxidase homolog	0.1145	0.4768	1
Brugia malayi	EGF-like domain containing protein	0.0219	0.0882	0.1851
Schistosoma mansoni	laminin gamma-3 chain	0.0219	0.0882	0.1588
Loa Loa (eye worm)	oxidoreductase	0.008	0.0296	0.062
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0115	0.0241
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0028	0.005
Schistosoma mansoni	polycystin 1-related	0.0079	0.0294	0.0528
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0018	0.0035	0.0035
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0037	0.0079
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.0035	0.0063
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0219	0.0395
Echinococcus granulosus	lipoxygenase domain containing protein	0.0079	0.0294	0.0528
Schistosoma mansoni	notch	0.0219	0.0882	0.1588
Schistosoma mansoni	aldo-keto reductase	0.008	0.0296	0.0532
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0219	0.1605
Schistosoma mansoni	notch	0.0219	0.0882	0.1588
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0018	0.0035	0.0073
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Onchocerca volvulus		0.008	0.0296	0.0551
Brugia malayi	Cadherin domain containing protein	0.0219	0.0882	0.1851
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.008	0.0296	0.2245
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0219	0.0882	0.1588
Trypanosoma brucei	protein kinase, putative	0.0062	0.0219	0.1605
Echinococcus granulosus	geminin	0.0205	0.082	0.1475
Brugia malayi	Delta serrate ligand family protein	0.0219	0.0882	0.1851
Onchocerca volvulus		0.0052	0.0181	0.0309
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0037	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0203	0.0425
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.008	0.0296	0.0296
Echinococcus granulosus	protein jagged 1	0.0219	0.0882	0.1588
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0018	0.0035	0.0035
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0154	0.0323
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.0401	0.8614
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Onchocerca volvulus		0.0079	0.0294	0.0547
Brugia malayi	nuclear hormone receptor	0.0018	0.0035	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Echinococcus granulosus	histone lysine methyltransferase setb	0.0037	0.0115	0.0207
Loa Loa (eye worm)	hypothetical protein	0.018	0.0718	0.1506
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0035	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0035	0.0073
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0219	0.0219
Echinococcus granulosus	lamin dm0	0.0052	0.0181	0.0326
Echinococcus granulosus	aldo keto reductase	0.008	0.0296	0.0532
Leishmania major	phosphopantetheinyl transferase-like protein	0.0045	0.0151	0.103
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0112	0.0112
Echinococcus multilocularis	GPCR, family 2	0.0061	0.0218	0.0218
Brugia malayi	nuclear receptor NHR-88	0.0018	0.0035	0.0073
Brugia malayi	Steroid receptor seven-up type 2	0.0018	0.0035	0.0073
Brugia malayi	EGF-like domain containing protein	0.0219	0.0882	0.1851
Onchocerca volvulus		0.0058	0.0203	0.0355
Loa Loa (eye worm)	hypothetical protein	0.018	0.0718	0.1506
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0112	0.0738
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0061	0.0218	0.0457
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.0035	0.0063
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.0401	0.313
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.0035	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0018	0.0035	0.0073
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0018	0.0035	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0177	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0635	0.1333
Echinococcus granulosus	GPCR family 2	0.0061	0.0218	0.0392
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.008	0.0296	0.062
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0154	0.1476
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.03	0.1221	1
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.03	0.1221	1
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0037	0.0351
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0187	0.1865
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0037	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0063	0.0133
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0154	0.1057
Echinococcus multilocularis	neural cadherin	0.0219	0.0882	0.0882
Brugia malayi	Intermediate filament tail domain containing protein	0.0052	0.0181	0.038
Brugia malayi	Phospholipase A2 family protein	0.0093	0.035	0.0735
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.0035	0.0063
Echinococcus multilocularis	aldo keto reductase	0.008	0.0296	0.0296
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0037	0.0351
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0066	0.0236	0.0425
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0161	0.0635	0.0635
Brugia malayi	Animal haem peroxidase family protein	0.1145	0.4768	1
Toxoplasma gondii	EGF family domain-containing protein	0.0219	0.0882	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0219	0.0219
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0018	0.0035	0.0073
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0231	0.0929	0.1672
Brugia malayi	Animal haem peroxidase family protein	0.1145	0.4768	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.035	0.0735
Trypanosoma brucei	hypothetical protein, conserved	0.0045	0.0151	0.103
Schistosoma mansoni	coup transcription factor	0.0018	0.0035	0.0063
Schistosoma mansoni	cell polarity protein	0.0219	0.0882	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0035	0.0073
Schistosoma mansoni	hypothetical protein	0.0219	0.0882	0.1588
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0219	0.1605
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0161	0.0635	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Schistosoma mansoni	intermediate filament proteins	0.0052	0.0181	0.0326
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.0035	0.0035
Entamoeba histolytica	hypothetical protein	0.0037	0.0115	0.2992
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0218	0.0457
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0474	0.1951	0.3509
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.008	0.0296	0.0532
Entamoeba histolytica	aldose reductase, putative	0.008	0.0296	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0018	0.0035	0.0073
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0018	0.0035	0.0063
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0061	0.0218	0.0457
Schistosoma mansoni	aldo-keto reductase	0.008	0.0296	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0067	0.0141
Schistosoma mansoni	peroxidasin	0.1145	0.4768	0.8578
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Schistosoma mansoni	hypothetical protein	0.0219	0.0882	0.1588
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Onchocerca volvulus		0.008	0.0296	0.0551
Schistosoma mansoni	hypothetical protein	0.0219	0.0882	0.1588
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0018	0.0035	0.0063
Echinococcus multilocularis	microtubule associated protein 2	0.1333	0.5558	0.5558
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.03	0.1221	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0018	0.0035	0.0063
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0115	0.0207
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0045	0.0151	0.103
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.008	0.0296	0.062
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.008	0.0296	0.2245
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0203	0.0365
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.008	0.0296	0.3134
Echinococcus granulosus	lipoxygenase domain containing protein	0.0079	0.0294	0.0528
Loa Loa (eye worm)	hypothetical protein	0.1145	0.4768	1
Schistosoma mansoni	potassium channel beta	0.008	0.0296	0.0532
Brugia malayi	MAP kinase sur-1	0.0062	0.0219	0.046
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.008	0.0296	0.0532
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0112	0.0201
Trypanosoma brucei	prostaglandin f synthase	0.008	0.0296	0.2245
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0112	0.0738
Brugia malayi	steroid hormone receptor	0.0018	0.0035	0.0073
Schistosoma mansoni	peroxidasin	0.1145	0.4768	0.8578
Echinococcus multilocularis	geminin	0.0205	0.082	0.082
Mycobacterium leprae	Possible oxidoreductase	0.008	0.0296	0.5637
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.0343	0.0719
Schistosoma mansoni	septate junction protein	0.0219	0.0882	0.1588
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0231	0.0929	0.0929
Onchocerca volvulus		0.008	0.0296	0.0551
Schistosoma mansoni	hypothetical protein	0.0061	0.0218	0.0392
Onchocerca volvulus	Putative cubilin	0.0219	0.0882	0.1791
Toxoplasma gondii	MAPEG family protein	0.0118	0.0457	0.5016
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0516	0.1083
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.03	0.1221	1
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	0.0515	0.2123	0.382
Loa Loa (eye worm)	Notch2	0.0219	0.0882	0.1851
Brugia malayi	hypothetical protein	0.0079	0.0294	0.0616
Loa Loa (eye worm)	hypothetical protein	0.008	0.0296	0.062
Plasmodium falciparum	aldehyde reductase, putative	0.008	0.0296	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.001	0.0021
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0028	0.0079	0.0166
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0018	0.0035	0.0035
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.008	0.0296	0.0296
Brugia malayi	Blistered cuticle protein 3	0.1145	0.4768	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0018	0.0035	0.0073
Schistosoma mansoni	rab6-interacting	0.0079	0.0294	0.0528
Trichomonas vaginalis	aldo-keto reductase, putative	0.008	0.0296	0.2357
Echinococcus granulosus	notch	0.0219	0.0882	0.1588
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.008	0.0296	0.0532
Brugia malayi	EGF-like domain containing protein	0.0219	0.0882	0.1851
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.045	0.3542
Echinococcus multilocularis	aldo keto reductase	0.008	0.0296	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0882	0.1851
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0154	0.4708

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (binding)	2.5119 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	4.6109 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	16.5113 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1543583

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1405713