Detailed information for compound 1409398

Basic information

Technical information
  • TDR Targets ID: 1409398
  • Name: (4-pyridin-2-yl-4,9-diazaspiro[5.5]undecan-9- yl)-(thiadiazol-4-yl)methanone
  • MW: 343.447 | Formula: C17H21N5OS
  • H donors: 0 H acceptors: 4 LogP: 2.41 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1csnn1)N1CCC2(CC1)CCCN(C2)c1ccccn1
  • InChi: 1S/C17H21N5OS/c23-16(14-12-24-20-19-14)21-10-6-17(7-11-21)5-3-9-22(13-17)15-4-1-2-8-18-15/h1-2,4,8,12H,3,5-7,9-11,13H2
  • InChiKey: VFDMBHJCLAMSMI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [4-(2-pyridyl)-4,9-diazaspiro[5.5]undecan-9-yl]-(thiadiazol-4-yl)methanone
  • [4-(2-pyridyl)-4,9-diazaspiro[5.5]undecan-9-yl]-(4-thiadiazolyl)methanone
  • (4-pyridin-2-yl-4,9-diazaspiro[5.5]undecan-9-yl)-(1,2,3-thiadiazol-4-yl)methanone
  • NCGC00010185
  • PCOP-60613

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0078 0.0237 0.2899
Schistosoma mansoni cytochrome P450 0.0017 0.0039 0.0284
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0237 0.1746
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0057 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0237 0.0327
Onchocerca volvulus 0.0023 0.0056 0.0375
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0057 0.0067
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0078 0.0237 0.2899
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0214
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0073 0.1355
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0237 0.1746
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0149 0.1959
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0138 0.0433 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni DNA helicase recq1 0.002 0.0049 0.0362
Brugia malayi hypothetical protein 0.0017 0.0038 0.0022
Onchocerca volvulus 0.0078 0.0237 0.2899
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.00000000036955
Leishmania major cytochrome p450-like protein 0.0028 0.0073 0.1802
Brugia malayi Cytochrome P450 family protein 0.0063 0.0189 0.0173
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0039 0.0042
Echinococcus multilocularis neuropeptide FF receptor 2 0.0078 0.0237 0.0327
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0017 0.0038 0.0041
Echinococcus granulosus intermediate filament protein 0.0026 0.0069 0.0085
Schistosoma mansoni neuropeptide receptor 0.0078 0.0237 0.1746
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.1697 0.5513 1
Schistosoma mansoni cpg binding protein 0.0031 0.0084 0.0622
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.0038 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0149 0.1102
Echinococcus multilocularis cpg binding protein 0.0031 0.0084 0.0107
Echinococcus granulosus lamin 0.0026 0.0069 0.0085
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0237 0.0327
Echinococcus multilocularis lamin 0.0026 0.0069 0.0085
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus multilocularis dro:myosuppressin receptor 0.0078 0.0237 0.0327
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0119 0.0189
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0057 0.0707
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0069 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0081 0.0594
Echinococcus multilocularis inhibitor of apoptosis protein 0.0214 0.0682 0.097
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.003 0.0014
Schistosoma mansoni histamine h1 receptor 0.0078 0.0237 0.1746
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0078 0.0237 0.1746
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0.0038 0.0022
Loa Loa (eye worm) trypsin family protein 0.0023 0.0056 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0073 1
Toxoplasma gondii microneme protein MIC17A 0.0014 0.003 0.0026
Loa Loa (eye worm) melatonin receptor type 1A 0.0078 0.0237 0.0221
Echinococcus granulosus dro:myosuppressin receptor 0.0078 0.0237 0.0327
Schistosoma mansoni DNA helicase recq5 0.002 0.0049 0.0362
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0237 0.1746
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Onchocerca volvulus 0.0214 0.0682 0.9132
Loa Loa (eye worm) cathepsin B 0.0046 0.0132 0.0116
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0078 0.0237 0.0221
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0057 0.5309
Toxoplasma gondii exonuclease III APE 0.0023 0.0057 0.0076
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0049 0.0033
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0038 0.0279
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0073 0.0057
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0078 0.0237 0.0327
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0237 0.1746
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.018 0.0299
Leishmania major hypothetical protein, conserved 0.0076 0.023 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0049 0.0779
Echinococcus granulosus neuropeptide receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0056 0.0415
Schistosoma mansoni hypothetical protein 0.0023 0.0056 0.0415
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0237 0.0327
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.0038 0.0022
Echinococcus granulosus neuropeptide receptor 0.0078 0.0237 0.0327
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0078 0.0237 0.0327
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0038 0.0279
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0447 0.0432
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.023 0.5119
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0056 0.0415
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0005 0.00000000036955
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0056 0.0415
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.0237 0.1746
Brugia malayi GnHR receptor homolog 0.0078 0.0237 0.0221
Schistosoma mansoni inhibitor of apoptosis protein 0.0214 0.0682 0.5033
Brugia malayi Serotonin receptor 0.0078 0.0237 0.0221
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0023 0.0056 0.0067
Onchocerca volvulus Deterin homolog 0.0214 0.0682 0.9132
Onchocerca volvulus 0.0078 0.0237 0.2899
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Loa Loa (eye worm) acetyltransferase 0.0142 0.0447 0.0432
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0237 0.0327
Echinococcus granulosus neuropeptide receptor A26 0.0078 0.0237 0.0327
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0237 0.0221
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0214 0.0682 0.097
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0057 0.0041
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.0189 0.0173
Onchocerca volvulus 0.0023 0.0056 0.0375
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Brugia malayi Dopamine receptor 0.0078 0.0237 0.0221
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.019 0.1402
Brugia malayi PAN domain containing protein 0.0014 0.003 0.0014
Schistosoma mansoni memapsin-2 (A01 family) 0.0421 0.1354 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0022
Brugia malayi hypothetical protein 0.0078 0.0237 0.0221
Onchocerca volvulus 0.0029 0.0079 0.069
Toxoplasma gondii cathepsin B 0.0046 0.0132 0.0211
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0049 0.0056
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0065
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0005 0.00000000036955
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0057 0.0966
Loa Loa (eye worm) hypothetical protein 0.0023 0.0056 0.004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0016 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0237 0.0327
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0237 0.0327
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0078 0.0237 0.1746
Schistosoma mansoni ap endonuclease 0.0023 0.0057 0.0419
Onchocerca volvulus 0.0026 0.0069 0.0555
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0056 0.0415
Schistosoma mansoni biogenic amine receptor 0.0078 0.0237 0.1746
Loa Loa (eye worm) hypothetical protein 0.0194 0.0616 0.0601
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0078 0.0237 0.1746
Brugia malayi Trypsin family protein 0.0194 0.0616 0.0601
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0075 0.0093
Loa Loa (eye worm) hypothetical protein 0.0026 0.0068 0.0052
Brugia malayi hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0056 0.0415
Brugia malayi hypothetical protein 0.0078 0.0237 0.0221
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0651 0.0636
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni intermediate filament proteins 0.0026 0.0069 0.051
Onchocerca volvulus 0.0078 0.0237 0.2899
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0237 0.0221
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni amine GPCR 0.0078 0.0237 0.1746
Schistosoma mansoni amine GPCR 0.0078 0.0237 0.1746
Echinococcus granulosus neuropeptide s receptor 0.0078 0.0237 0.0327
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.0039 0.5
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0038 0.0279
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus multilocularis tissue type plasminogen activator 0.0076 0.023 0.0317
Schistosoma mansoni hypothetical protein 0.0214 0.0682 0.5033
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0078 0.0237 0.0221
Onchocerca volvulus 0.0078 0.0237 0.2899
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0057 0.0041
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0149 0.3186
Brugia malayi PAN domain containing protein 0.0014 0.003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Loa Loa (eye worm) hypothetical protein 0.0023 0.0056 0.004
Schistosoma mansoni hypothetical protein 0.0078 0.0237 0.1746
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0057 0.0067
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0023 0.0056 0.0041
Toxoplasma gondii hypothetical protein 0.0014 0.003 0.0026
Brugia malayi PAN domain containing protein 0.0014 0.003 0.0014
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0132 0.097
Schistosoma mansoni adenoreceptor 0.0078 0.0237 0.1746
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.0038 0.0022
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0025 0.0021
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0017 0.0038 0.0041
Onchocerca volvulus 0.0078 0.0237 0.2899
Brugia malayi RE15519p 0.0078 0.0237 0.0221
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0001
Loa Loa (eye worm) hypothetical protein 0.0214 0.0682 0.0666
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0039 0.0527
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0038 0.0279
Echinococcus multilocularis serotonin receptor 0.0078 0.0237 0.0327
Brugia malayi follicle stimulating hormone receptor 0.0356 0.1142 0.1128
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0017 0.0038 0.004
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0049 0.0033
Mycobacterium leprae putative cytochrome p450 0.0017 0.0039 0.5
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0081 0.0102
Brugia malayi Tachykinin-like peptides receptor 99D 0.0078 0.0237 0.0221
Brugia malayi Kringle domain containing protein 0.0076 0.023 0.0214
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0078 0.0237 0.0327
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0237 0.0327
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0214 0.0682 0.097
Plasmodium vivax plasmepsin V, putative 0.0017 0.0038 0.1655
Brugia malayi CXXC zinc finger family protein 0.0029 0.0079 0.0063
Schistosoma mansoni hypothetical protein 0.0078 0.0237 0.1746
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0078 0.0237 0.0327
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0039 0.0527
Loa Loa (eye worm) TYRA-2 protein 0.0078 0.0237 0.0221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0237 0.1746
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0138 0.0433 0.0418
Brugia malayi Trypsin family protein 0.0023 0.0056 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0033
Brugia malayi hypothetical protein 0.0078 0.0237 0.0221
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0237 0.0221
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0447 0.0631
Onchocerca volvulus 0.0078 0.0237 0.2899
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0057 0.0777
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0356 0.1142 0.1127
Plasmodium vivax aspartyl protease, putative 0.0017 0.0038 0.1655
Schistosoma mansoni lamin 0.0026 0.0069 0.051
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0743 1
Schistosoma mansoni biogenic amine receptor 0.0078 0.0237 0.1746
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0237 0.1746
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0237 0.0327
Brugia malayi hypothetical protein 0.0017 0.0038 0.0022
Echinococcus granulosus cathepsin b 0.0138 0.0433 0.0611
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0023 0.0056 0.0415
Onchocerca volvulus 0.0026 0.0069 0.0555
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0038 0.0279
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0017 0.0122
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0237 0.1746
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0237 0.0221
Brugia malayi putative neuropeptide receptor NPR1 0.0078 0.0237 0.0221
Trypanosoma brucei protein kinase, putative 0.0051 0.0149 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Brugia malayi hypothetical protein 0.0078 0.0237 0.0221
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus granulosus somatostatin receptor 0.0078 0.0237 0.0327
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0015 0.0673
Echinococcus multilocularis Mastin 0.0023 0.0056 0.0067
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0056 0.0415
Onchocerca volvulus 0.0076 0.023 0.2806
Brugia malayi Serotonin receptor 0.0078 0.0237 0.0221
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0237 0.0327
Echinococcus granulosus transmembrane protease serine 3 0.0023 0.0056 0.0067
Schistosoma mansoni alpha-1 adrenergic receptor 0.0078 0.0237 0.1746
Brugia malayi cytochrome P450 0.0017 0.0039 0.0023
Loa Loa (eye worm) aspartyl protease 6 0.0017 0.0038 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0073 0.1355
Toxoplasma gondii PAN domain-containing protein 0.0014 0.003 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0237 0.1746
Toxoplasma gondii PAN domain-containing protein 0.0014 0.003 0.0026
Schistosoma mansoni hypothetical protein 0.0078 0.0237 0.1746
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.00000000036955
Entamoeba histolytica recQ family DNA helicase 0.001 0.0017 0.0139
Brugia malayi Cytochrome P450 family protein 0.0028 0.0073 0.0057
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0057 0.2479
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Onchocerca volvulus 0.0078 0.0237 0.2899
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0056 0.0067
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.003 0.0014
Schistosoma mansoni neuropeptide receptor 0.0078 0.0237 0.1746
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0049 0.0061
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0073 0.3113
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus granulosus enteropeptidase 0.0023 0.0056 0.0067
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0049 0.0056
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0108 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0149 0.0244
Entamoeba histolytica recQ family helicase, putative 0.002 0.0049 0.3643
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0057 0.0987
Toxoplasma gondii microneme protein, putative 0.0014 0.003 0.0026
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0078 0.0237 0.0221
Schistosoma mansoni lamin 0.0026 0.0069 0.051
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus multilocularis cathepsin b 0.0138 0.0433 0.0611
Echinococcus granulosus hypothetical protein 0.0078 0.0237 0.0327
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0049 0.0602
Toxoplasma gondii aspartyl protease ASP3 0.0017 0.0038 0.0041
Echinococcus multilocularis somatostatin receptor 0.0078 0.0237 0.0327
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0049 0.0581
Schistosoma mansoni opsin-like receptor 0.0078 0.0237 0.1746
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0014
Echinococcus granulosus g-protein coupled receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0023 0.0056 0.004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0119 0.0158
Echinococcus multilocularis neuropeptide receptor 0.0078 0.0237 0.0327
Schistosoma mansoni opsin-like receptor 0.0078 0.0237 0.1746
Onchocerca volvulus 0.0078 0.0237 0.2899
Schistosoma mansoni amine GPCR 0.0078 0.0237 0.1746
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0023 0.0056 0.0067
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0078 0.0237 0.0327
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.003 0.0014
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0078 0.0237 0.0221
Onchocerca volvulus 0.0078 0.0237 0.2899
Schistosoma mansoni cpg binding protein 0.0031 0.0084 0.0622
Schistosoma mansoni hypothetical protein 0.0023 0.0056 0.0415
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0194 0.0616 0.4549
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni hypothetical protein 0.0076 0.023 0.1697
Toxoplasma gondii aspartyl protease ASP1 0.0017 0.0038 0.0041
Brugia malayi hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0038 0.0279
Brugia malayi cathepsin B-like cysteine proteinase 0.0138 0.0433 0.0418
Brugia malayi PAN domain containing protein 0.0014 0.003 0.0014
Schistosoma mansoni amine GPCR 0.0078 0.0237 0.1746
Echinococcus multilocularis orexin receptor type 2 0.0078 0.0237 0.0327
Schistosoma mansoni neuropeptide receptor 0.0078 0.0237 0.1746
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0078 0.0237 0.0221
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0078 0.0237 0.1746
Echinococcus granulosus 7tm_1 domain containing protein 0.0078 0.0237 0.0327
Brugia malayi G protein-coupled receptor F59B2.13 0.0078 0.0237 0.0221
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0434 0.0612
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0078 0.0237 0.1746
Echinococcus multilocularis neuropeptide s receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0069 0.0053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0057 0.0966
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Brugia malayi PAN domain containing protein 0.0014 0.003 0.0014
Onchocerca volvulus 0.0023 0.0056 0.0375
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0237 0.0327
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0056 0.0415
Brugia malayi G protein-coupled receptor 0.0078 0.0237 0.0221
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0081 0.0102
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0237 0.1746
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0237 0.1746
Brugia malayi Protein kinase domain containing protein 0.0076 0.023 0.0214
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0049 0.0581
Onchocerca volvulus 0.0017 0.0038 0.0117
Toxoplasma gondii microneme protein MIC17C 0.0014 0.003 0.0026
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0017 0.0002
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0057 1
Onchocerca volvulus 0.0172 0.0542 0.7184
Echinococcus multilocularis glycoprotein Antigen 5 0.0023 0.0056 0.0067
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0149 0.3186
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0149 0.0201
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0029 0.0013
Onchocerca volvulus 0.0017 0.0038 0.0117
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0056 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0132 0.1717
Giardia lamblia Cathepsin B precursor 0.0046 0.0132 0.8219
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0214 0.0682 0.5033
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0149 0.1959
Echinococcus multilocularis g-protein coupled receptor 0.0078 0.0237 0.0327
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0023 0.0056 0.0067
Onchocerca volvulus 0.0233 0.0743 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0078 0.0237 0.1746
Brugia malayi AKH receptor 0.0078 0.0237 0.0221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Echinococcus multilocularis G protein coupled receptor 139 0.0078 0.0237 0.0327
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.003 0.0014
Echinococcus multilocularis cathepsin b 0.0138 0.0433 0.0611
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.00000000036955
Echinococcus granulosus alpha 1A adrenergic receptor 0.0078 0.0237 0.0327
Onchocerca volvulus 0.0023 0.0056 0.0375
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0108 0.5875
Loa Loa (eye worm) cytochrome P450 0.0017 0.0039 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0014
Echinococcus granulosus cpg binding protein 0.0031 0.0084 0.0107
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0149 0.0201
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0029 0.0013
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0073 0.0057
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Plasmodium vivax plasmepsin IV, putative 0.0017 0.0038 0.1655
Schistosoma mansoni cpg binding protein 0.0029 0.0079 0.0581
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0049 0.0033
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0026 0.0069 0.0053
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0038 0.1655
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0078 0.0237 0.0327
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0057 0.4484
Brugia malayi G-protein coupled receptor 0.0078 0.0237 0.0221
Echinococcus multilocularis neuropeptide receptor A26 0.0078 0.0237 0.0327
Echinococcus granulosus g protein coupled receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0149 0.1959
Echinococcus granulosus peptide allatostatin:somatostatin 0.0078 0.0237 0.0327
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0038 0.0279
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Brugia malayi hypothetical protein 0.0078 0.0237 0.0221
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0057 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0057 0.0957
Schistosoma mansoni ap endonuclease 0.0023 0.0057 0.0419
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0076 0.023 1
Echinococcus granulosus g protein coupled receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0078 0.0237 0.1746
Schistosoma mansoni growth hormone secretagogue receptor 0.0078 0.0237 0.1746
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0149 0.3186
Plasmodium vivax aspartyl protease, putative 0.0017 0.0038 0.1655
Echinococcus granulosus bloom syndrome protein 0.002 0.0049 0.0056
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0138 0.0433 0.3199
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0049 0.0033
Echinococcus granulosus neuropeptide FF receptor 2 0.0078 0.0237 0.0327
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0056 0.0415
Toxoplasma gondii PAN domain-containing protein 0.0014 0.003 0.0026
Toxoplasma gondii microneme protein MIC17B 0.0014 0.003 0.0026
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0119 0.1553
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0078 0.0237 0.0327
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0049 0.0056
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0078 0.0237 0.1746
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Loa Loa (eye worm) RecQ helicase 0.002 0.0049 0.0033
Echinococcus granulosus glycoprotein Antigen 5 0.0023 0.0056 0.0067
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.001 0.0074
Brugia malayi hypothetical protein 0.0078 0.0237 0.0221
Echinococcus granulosus allatostatin A receptor 0.0078 0.0237 0.0327
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.00000000036955
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0017 0.0038 0.0451
Brugia malayi Trypsin-like protease protein 5 0.0023 0.0056 0.0041
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0119 0.0189
Brugia malayi Pre-SET motif family protein 0.0205 0.0651 0.0637
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.0433 0.3199
Echinococcus multilocularis allatostatin A receptor 0.0078 0.0237 0.0327
Onchocerca volvulus 0.0078 0.0237 0.2899
Brugia malayi PAN domain containing protein 0.0014 0.003 0.0014
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0073 0.0057
Schistosoma mansoni myosin xvIII 0.0078 0.0237 0.1746
Brugia malayi Trypsin family protein 0.0023 0.0056 0.0041
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2133 0.6934 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0056 0.004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0038 0.0279
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0014
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.0237 0.0327
Toxoplasma gondii microneme protein MIC4 0.0014 0.003 0.0026
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0237 0.0327
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0025 0.0021
Echinococcus granulosus tissue type plasminogen activator 0.0076 0.023 0.0317
Loa Loa (eye worm) hypothetical protein 0.0214 0.0682 0.0666
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0039 0.0041
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0237 0.0327
Brugia malayi sulfakinin receptor protein 0.0078 0.0237 0.0221
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0022
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0119 0.1553
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0149 0.579
Toxoplasma gondii PAN domain-containing protein 0.0014 0.003 0.0026
Echinococcus multilocularis neuropeptide receptor 0.0078 0.0237 0.0327
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0056 0.0415
Brugia malayi Cytochrome P450 family protein 0.0017 0.0039 0.0023
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0149 0.0133
Toxoplasma gondii subtilisin SUB12 0.0014 0.003 0.0026
Brugia malayi neuropeptide F receptor 0.0078 0.0237 0.0221
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0046 0.0132 0.4856
Brugia malayi PAN domain containing protein 0.0014 0.003 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0237 0.1746
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0014 0.003 0.0026
Brugia malayi intermediate filament protein 0.0026 0.0069 0.0054
Toxoplasma gondii PAN domain-containing protein 0.0014 0.003 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0081 0.0594
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0014
Plasmodium falciparum cysteine repeat modular protein 1 0.0076 0.023 1
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0049 0.0602
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0057 0.0707
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0049 0.0602
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0056 0.0415
Onchocerca volvulus 0.0023 0.0056 0.0375
Echinococcus granulosus Mastin 0.0023 0.0056 0.0067
Loa Loa (eye worm) TK/ROR protein kinase 0.0076 0.023 0.0214
Giardia lamblia Cathepsin B precursor 0.0046 0.0132 0.8219
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0056 0.0415
Brugia malayi PAN domain containing protein 0.0014 0.003 0.0014
Plasmodium vivax SET domain protein, putative 0.003 0.0081 0.3508
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0237 0.1746
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0069 0.0054
Brugia malayi putative neuropeptide receptor 0.0078 0.0237 0.0221
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0056 0.0415
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0081 0.0594
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.0433 0.3199
Brugia malayi Pre-SET motif family protein 0.003 0.0081 0.0065
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0078 0.0237 0.0221
Onchocerca volvulus 0.0078 0.0237 0.2899
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0049 0.0949
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0001
Echinococcus multilocularis G-protein coupled receptor, putative 0.0078 0.0237 0.0327
Schistosoma mansoni hypothetical protein 0.0419 0.1349 0.9967
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0108 0.3649
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0237 0.1746
Brugia malayi Cytochrome P450 family protein 0.0028 0.0073 0.0057
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0015 0.0112
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0149 0.579
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Onchocerca volvulus 0.0194 0.0616 0.8213
Echinococcus multilocularis 0.0017 0.0039 0.0041
Echinococcus multilocularis transmembrane protease serine 3 0.0023 0.0056 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.00000000036955
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0149 0.1959
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0056 0.0415
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Brugia malayi Dopamine receptor protein 2 0.0078 0.0237 0.0221
Echinococcus granulosus dnaJ subfamily B 0.0419 0.1349 0.1934
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0016 0.0008
Echinococcus multilocularis serotonin receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0078 0.0237 0.0221
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus granulosus sex peptide receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0079 0.0063
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0046 0.0132 0.2757
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0017 0.0729
Brugia malayi larval opioid receptor 0.0078 0.0237 0.0221
Echinococcus granulosus g protein coupled receptor 0.0078 0.0237 0.0327
Brugia malayi hypothetical protein 0.0078 0.0237 0.0221
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0237 0.0327
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0237 0.0327
Brugia malayi MAP kinase sur-1 0.0051 0.0149 0.0134
Toxoplasma gondii PAN domain-containing protein 0.0014 0.003 0.0026
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.1349 0.1934
Echinococcus multilocularis lamin dm0 0.0026 0.0069 0.0085
Brugia malayi Pepsin A precursor 0.0017 0.0038 0.0022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0007
Echinococcus granulosus serotonin receptor 0.0078 0.0237 0.0327
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0149 1
Toxoplasma gondii kringle domain-containing protein 0.0076 0.023 0.039
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0017 0.0038 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0049 0.055
Echinococcus multilocularis bloom syndrome protein 0.002 0.0049 0.0056
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.0237 0.1746
Brugia malayi Dopamine receptor protein 1 0.0078 0.0237 0.0221
Giardia lamblia Cathepsin B precursor 0.0046 0.0132 0.8219
Brugia malayi neuropeptide F receptor 0.0078 0.0237 0.0221
Brugia malayi PAN domain containing protein 0.0014 0.003 0.0014
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0056 0.0415
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0447 0.3301
Toxoplasma gondii aspartyl protease 0.0017 0.0038 0.0041
Onchocerca volvulus 0.0078 0.0237 0.2899
Echinococcus granulosus 7TM GPCR rhodopsin 0.0078 0.0237 0.0327
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0214 0.0682 0.0667
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0038 0.0279
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0057 0.1653
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0078 0.0237 0.0327
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0237 0.0327
Schistosoma mansoni amine GPCR 0.0078 0.0237 0.1746
Schistosoma mansoni biogenic amine receptor 0.0078 0.0237 0.1746
Onchocerca volvulus Neuropeptide F receptor homolog 0.0078 0.0237 0.2899
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0081 0.0119
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0056 0.0415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Plasmodium vivax aspartyl protease, putative 0.0017 0.0038 0.1655
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0237 0.0327
Onchocerca volvulus 0.0078 0.0237 0.2899
Echinococcus granulosus orexin receptor type 2 0.0078 0.0237 0.0327
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0237 0.1746
Onchocerca volvulus 0.003 0.0081 0.0714
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0078 0.0237 0.0221
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0014
Echinococcus granulosus inhibitor of apoptosis protein 0.0214 0.0682 0.097
Toxoplasma gondii PAN/Apple domain-containing protein 0.0014 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0017 0.0038 0.004
Loa Loa (eye worm) hypothetical protein 0.0194 0.0616 0.0601
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0049 0.0061
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0149 0.0201
Onchocerca volvulus 0.0078 0.0237 0.2899
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.3074 1 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0038 0.0279
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0149 0.0201
Echinococcus granulosus tm gpcr rhodopsin 0.2133 0.6934 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.003 0.0014
Echinococcus granulosus tachykinin peptides receptor 99D 0.0078 0.0237 0.0327
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.0038 0.0279
Echinococcus granulosus fmrfamide receptor 0.0078 0.0237 0.0327
Mycobacterium ulcerans hypothetical protein 0.0023 0.0056 0.5153
Echinococcus granulosus lamin dm0 0.0026 0.0069 0.0085
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0049 0.0056
Onchocerca volvulus 0.0078 0.0237 0.2899
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0149 0.3186
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Onchocerca volvulus 0.0078 0.0237 0.2899
Schistosoma mansoni hypothetical protein 0.0078 0.0237 0.1746
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0237 0.0327
Brugia malayi ORL1-like opioid receptor 0.0078 0.0237 0.0221
Echinococcus multilocularis sex peptide receptor 0.0078 0.0237 0.0327
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0014
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0237 0.0327
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0081 0.0594
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0078 0.0237 0.0221
Echinococcus multilocularis enteropeptidase 0.0023 0.0056 0.0067
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0237 0.0327
Brugia malayi Trypsin family protein 0.0023 0.0056 0.0041
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0214 0.0682 0.0667
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0194 0.0616 0.4549
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0237 0.1746
Brugia malayi hypothetical protein 0.0023 0.0056 0.0041
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.0038 0.1655
Toxoplasma gondii hypothetical protein 0.0014 0.003 0.0026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0056 0.0415
Echinococcus granulosus G protein coupled receptor 139 0.0078 0.0237 0.0327
Echinococcus multilocularis musashi 0.0026 0.0069 0.0085
Brugia malayi PAN domain containing protein 0.0014 0.003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0022
Brugia malayi G-protein coupled receptor 0.0078 0.0237 0.0221
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0119 0.5195
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0237 0.0327
Schistosoma mansoni hypothetical protein 0.0017 0.0039 0.0284
Brugia malayi Melatonin receptor type 1A 0.0078 0.0237 0.0221
Trypanosoma brucei cysteine peptidase C (CPC) 0.0046 0.0132 0.8388
Brugia malayi hypothetical protein 0.0078 0.0237 0.0221
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0039 0.0527
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0237 0.0327
Loa Loa (eye worm) hypothetical protein 0.0078 0.0237 0.0221
Schistosoma mansoni opsin-like receptor 0.0078 0.0237 0.1746
Echinococcus granulosus cathepsin b 0.0138 0.0433 0.0611
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0237 0.0327
Schistosoma mansoni neuropeptide receptor 0.0078 0.0237 0.1746
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0237 0.1746
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.0433 0.3199
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0005 0.00000000036955
Schistosoma mansoni neuropeptide f receptor 76f 0.0078 0.0237 0.1746

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 19.95262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.1413 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (ADMET) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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