Detailed information for compound 1412127

Basic information

Technical information
  • TDR Targets ID: 1412127
  • Name: 2-(4-oxo-1-phenylpyrazolo[5,4-d]pyrimidin-5-y l)-N-(phenylmethyl)acetamide
  • MW: 359.381 | Formula: C20H17N5O2
  • H donors: 1 H acceptors: 3 LogP: 2.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1cnc2c(c1=O)cnn2c1ccccc1)NCc1ccccc1
  • InChi: 1S/C20H17N5O2/c26-18(21-11-15-7-3-1-4-8-15)13-24-14-22-19-17(20(24)27)12-23-25(19)16-9-5-2-6-10-16/h1-10,12,14H,11,13H2,(H,21,26)
  • InChiKey: LMWLVRWPRMZPQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-oxo-1-phenyl-pyrazolo[5,4-d]pyrimidin-5-yl)-N-(phenylmethyl)acetamide
  • 2-(4-oxo-1-phenyl-5-pyrazolo[5,4-d]pyrimidinyl)-N-(phenylmethyl)acetamide
  • N-(benzyl)-2-(4-keto-1-phenyl-pyrazolo[5,4-d]pyrimidin-5-yl)acetamide
  • 2-(4-oxo-1-phenyl-pyrazolo[5,4-d]pyrimidin-5-yl)-N-(phenylmethyl)ethanamide
  • BAS 06481320
  • IDI1_006297
  • ZINC00801462
  • ChemDiv2_007582
  • MLS000034417
  • N-Benzyl-2-(4-oxo-1-phenyl-1,4-dihydro-pyrazolo[3,4-d]pyrimidin-5-yl)-acetamide
  • SMR000013761

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0077 0.0424 0.0566
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0665 0.2305
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0472 0.3699 0.3699
Loa Loa (eye worm) calpain family protein 1 0.0053 0.0221 0.0294
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0365 0.2815 0.3756
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0241 0.0241
Onchocerca volvulus 0.0248 0.1846 0.6557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0665 0.2305
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0224 0.164 0.164
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0143 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0077 0.0424 0.1445
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0117 0.0751 0.1003
Entamoeba histolytica hypothetical protein 0.0077 0.0424 0.1445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Giardia lamblia Hypothetical protein 0.0077 0.0424 0.2851
Loa Loa (eye worm) hypothetical protein 0.0248 0.1846 0.2463
Plasmodium falciparum prefoldin subunit 6, putative 0.0061 0.0292 0.097
Brugia malayi Cathepsin L-like precursor 0.0248 0.1846 0.2463
Loa Loa (eye worm) hypothetical protein 0.0037 0.0086 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.3198 1
Brugia malayi calpain family protein 1 0.0053 0.0221 0.0294
Giardia lamblia Cathepsin B precursor 0.0077 0.0424 0.2851
Schistosoma mansoni cathepsin F (C01 family) 0.0365 0.2815 0.2815
Giardia lamblia Cysteine protease 0.0077 0.0424 0.2851
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0243 0.18 0.2401
Brugia malayi Eukaryotic aspartyl protease family protein 0.0068 0.0347 0.0463
Leishmania major hypothetical protein, conserved 0.0049 0.0192 0.0342
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0053 0.0221 0.0221
Onchocerca volvulus Cathepsin L homolog 0.0077 0.0424 0.1508
Brugia malayi hypothetical protein 0.0241 0.1781 0.2377
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0347 0.0347
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0086 0.0234
Echinococcus multilocularis microtubule associated protein 2 0.0756 0.6064 0.8092
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0288 0.2172 0.2898
Toxoplasma gondii cathepsin CPC1 0.0077 0.0424 0.1445
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0424 0.0424
Echinococcus multilocularis prefoldin subunit 6 0.0061 0.0292 0.0389
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0424 0.0424
Giardia lamblia Cathepsin L-like protease 0.0077 0.0424 0.2851
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0755 0.1008
Brugia malayi cathepsin Z-like cysteine proteinase 0.0077 0.0424 0.0566
Trypanosoma cruzi prefoldin subunit, putative 0.0061 0.0292 0.0569
Leishmania major hypothetical protein, conserved 0.0043 0.0143 0.0185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.053 0.0707
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0077 0.0424 0.1445
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.1781 0.2377
Plasmodium falciparum cysteine proteinase falcipain 1 0.0194 0.1393 0.4913
Loa Loa (eye worm) aspartyl protease 6 0.0068 0.0347 0.0463
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0424 0.1445
Plasmodium vivax serine-repeat antigen (SERA) 0.0077 0.0424 0.1445
Trypanosoma cruzi cysteine peptidase, putative 0.0411 0.3198 0.8613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0424 0.1445
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0665 0.0887
Echinococcus granulosus cathepsin b 0.0472 0.3699 0.4936
Loa Loa (eye worm) ctsf protein 0.0365 0.2815 0.3756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.1393 0.4913
Loa Loa (eye worm) hypothetical protein 0.0039 0.0105 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.1846 0.6532
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0192 0.0294
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0299 0.0299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.1393 0.4201
Brugia malayi cathepsin F-like cysteine proteinase 0.0077 0.0424 0.0566
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0665 0.0887
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0424 0.1445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.3198 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0299 0.0299
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0199 0.1437 0.1437
Giardia lamblia Cathepsin B precursor 0.0199 0.1437 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0143 0.0191
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Plasmodium vivax aspartyl protease, putative 0.0068 0.0347 0.1169
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0077 0.0424 0.1445
Onchocerca volvulus 0.0365 0.2815 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0077 0.0424 0.1445
Plasmodium vivax unspecified product 0.0194 0.1393 0.4913
Brugia malayi Papain family cysteine protease containing protein 0.0077 0.0424 0.0566
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Onchocerca volvulus Cathepsin F homolog 0.0365 0.2815 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0077 0.0424 0.0424
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0299 0.0299
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0288 0.2172 0.2898
Plasmodium vivax aspartyl protease, putative 0.0068 0.0347 0.1169
Brugia malayi KE2 family protein 0.0061 0.0292 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0424 0.1445
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.1781 0.2377
Giardia lamblia Cathepsin B precursor 0.0199 0.1437 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.3198 1
Plasmodium falciparum plasmepsin X 0.0068 0.0347 0.1169
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0077 0.0424 0.1445
Plasmodium falciparum plasmepsin VIII, putative 0.0068 0.0347 0.1169
Brugia malayi aspartic protease BmAsp-1, identical 0.0068 0.0347 0.0463
Giardia lamblia Cysteine protease 0.0077 0.0424 0.2851
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0299 0.0398
Leishmania major cathepsin L-like protease 0.0365 0.2815 0.8768
Brugia malayi hypothetical protein 0.0068 0.0347 0.0463
Brugia malayi Pepsin A precursor 0.0068 0.0347 0.0463
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0077 0.0424 0.1445
Giardia lamblia Cysteine protease 0.0077 0.0424 0.2851
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0665 0.1859
Giardia lamblia Cathepsin B precursor 0.0077 0.0424 0.2851
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0143 0.0287
Toxoplasma gondii cathepsin CPL 0.0365 0.2815 1
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0665 0.0665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0192 0.0614
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0077 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0365 0.2815 1
Brugia malayi Cathepsin L-like precursor 0.0365 0.2815 0.3756
Leishmania major cathepsin L-like protease 0.0411 0.3198 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0347 0.0463
Toxoplasma gondii aspartyl protease ASP1 0.0288 0.2172 0.7698
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0143 0.0287
Loa Loa (eye worm) hypothetical protein 0.0077 0.0424 0.0566
Plasmodium falciparum plasmepsin II 0.0288 0.2172 0.7698
Plasmodium vivax unspecified product 0.0117 0.0751 0.2615
Plasmodium falciparum cysteine proteinase falcipain 3 0.0365 0.2815 1
Leishmania major cathepsin L-like protease 0.0411 0.3198 1
Onchocerca volvulus 0.0365 0.2815 1
Brugia malayi TAR-binding protein 0.0062 0.0299 0.0398
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.053 0.0707
Trypanosoma cruzi cysteine peptidase, putative 0.0194 0.1393 0.3619
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.019 0.0254
Leishmania major prefoldin subunit, putative 0.0061 0.0292 0.0661
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0665 0.0887
Trypanosoma brucei cysteine peptidase C (CPC) 0.0199 0.1437 0.4342
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.1393 0.4913
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0077 0.0424 0.0424
Toxoplasma gondii aspartyl protease 0.0068 0.0347 0.1169
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0143 0.0191
Toxoplasma gondii prefoldin subunit 6, putative 0.0061 0.0292 0.097
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0665 0.0665
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0077 0.0424 0.1445
Giardia lamblia Hypothetical protein 0.0061 0.0292 0.1913
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0143 0.0191
Plasmodium falciparum serine repeat antigen 6 0.0077 0.0424 0.1445
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0077 0.0424 0.1445
Loa Loa (eye worm) hypothetical protein 0.0047 0.0171 0.0228
Echinococcus granulosus cathepsin l1 0.0248 0.1846 0.2463
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Brugia malayi 6-phosphofructokinase 0.0106 0.0665 0.0887
Onchocerca volvulus 0.0365 0.2815 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0665 0.2887
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.1393 0.4201
Brugia malayi cathepsin L precursor 0.0077 0.0424 0.0566
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0665 0.0887
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.1393 0.1393
Plasmodium vivax prefoldin subunit 6, putative 0.0061 0.0292 0.097
Entamoeba histolytica cysteine protease, putative 0.0077 0.0424 0.1445
Echinococcus granulosus cathepsin b 0.0472 0.3699 0.4936
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Brugia malayi beta-lactamase family protein 0.0043 0.0143 0.0191
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0105 0.014
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0086 0.0305
Onchocerca volvulus 0.0043 0.0143 0.051
Loa Loa (eye worm) hypothetical protein 0.0043 0.0143 0.0191
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0665 1
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0192 0.0614
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0347 0.0347
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Echinococcus granulosus cysteine protease 0.0194 0.1393 0.186
Brugia malayi Papain family cysteine protease containing protein 0.0077 0.0424 0.0566
Plasmodium falciparum serine repeat antigen 2 0.0077 0.0424 0.1445
Plasmodium falciparum serine repeat antigen 4 0.0077 0.0424 0.1445
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0143 0.0143
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0472 0.3699 0.3699
Brugia malayi hypothetical protein 0.0049 0.0192 0.0257
Plasmodium vivax plasmepsin V, putative 0.0068 0.0347 0.1169
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0086 0.0234
Brugia malayi beta-lactamase 0.0043 0.0143 0.0191
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0055 0.0241 0.0321
Leishmania major cathepsin L-like protease 0.0365 0.2815 0.8768
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.1393 0.1393
Brugia malayi hypothetical protein 0.0068 0.0347 0.0463
Plasmodium falciparum plasmepsin IX 0.0068 0.0347 0.1169
Brugia malayi beta-lactamase family protein 0.0043 0.0143 0.0191
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0288 0.2172 0.2898
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.053 0.053
Echinococcus multilocularis cysteine protease 0.0365 0.2815 0.3756
Onchocerca volvulus 0.0043 0.0143 0.051
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.025 0.1861 0.2483
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.053 0.0707
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0665 1
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Schistosoma mansoni hypothetical protein 0.0205 0.1482 0.1482
Loa Loa (eye worm) hypothetical protein 0.0117 0.0751 0.1003
Brugia malayi Cathepsin L-like precursor 0.0365 0.2815 0.3756
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.1393 0.186
Plasmodium falciparum plasmepsin V 0.0068 0.0347 0.1169
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0288 0.2172 0.7698
Plasmodium falciparum plasmepsin IV 0.0288 0.2172 0.7698
Chlamydia trachomatis pyruvate kinase 0.0037 0.0086 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0068 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0117 0.0751 0.1003
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0077 0.0424 0.1445
Plasmodium falciparum pyruvate kinase 0.0037 0.0086 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.3198 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0424 0.0566
Echinococcus granulosus calpain A 0.0055 0.0241 0.0321
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.209 1
Plasmodium falciparum serine repeat antigen 8 0.0077 0.0424 0.1445
Loa Loa (eye worm) hypothetical protein 0.0043 0.0143 0.0191
Loa Loa (eye worm) hypothetical protein 0.0043 0.0143 0.0191
Mycobacterium leprae Probable lipase LipE 0.0043 0.0143 0.0994
Toxoplasma gondii cathepsin CPC2 0.0077 0.0424 0.1445
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0424 0.1445
Leishmania major cysteine peptidase A (CPA) 0.0365 0.2815 0.8768
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0077 0.0424 0.2851
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0424 0.1445
Loa Loa (eye worm) hypothetical protein 0.0117 0.0751 0.1003
Brugia malayi Papain family cysteine protease containing protein 0.0365 0.2815 0.3756
Leishmania major cathepsin L-like protease 0.0411 0.3198 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0424 0.0566
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0077 0.0424 0.1445
Entamoeba histolytica cysteine proteinase, putative 0.0365 0.2815 1
Trypanosoma cruzi cysteine peptidase, putative 0.0411 0.3198 0.8613
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0928 0.7494 1
Plasmodium vivax vivapain-1 0.0194 0.1393 0.4913
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0077 0.0424 0.0566
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0143 0.0994
Onchocerca volvulus 0.0049 0.019 0.0675
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0143 0.0287
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0086 0.0115
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0365 0.2815 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.0299 0.0398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0347 0.0347
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0077 0.0424 0.1445
Trypanosoma cruzi major cysteine proteinase, putative 0.0077 0.0424 0.0937
Trypanosoma cruzi cysteine peptidase, putative 0.0117 0.0751 0.1841
Trypanosoma cruzi cysteine protease, putative 0.0194 0.1393 0.3619
Onchocerca volvulus Cathepsin L homolog 0.0365 0.2815 1
Toxoplasma gondii aspartyl protease ASP3 0.0068 0.0347 0.1169
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0192 0.0614
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0424 0.0424
Schistosoma mansoni hypothetical protein 0.0049 0.019 0.019
Schistosoma mansoni survival motor neuron protein 0.0049 0.019 0.019
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0347 0.0347
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0192 0.0614
Mycobacterium ulcerans lipase LipD 0.0043 0.0143 0.0994
Trichomonas vaginalis esterase, putative 0.0043 0.0143 0.044
Entamoeba histolytica cysteine proteinase, putative 0.0248 0.1846 0.6532
Brugia malayi fibroinase precursor 0.0077 0.0424 0.0566
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0299 0.0398
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0621 0.4945 0.6598
Echinococcus granulosus cathepsin L cysteine proteinase 0.0365 0.2815 0.3756
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0347 0.0347
Schistosoma mansoni pyruvate kinase 0.0037 0.0086 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0365 0.2815 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0665 1
Brugia malayi hypothetical protein 0.0032 0.0047 0.0063
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0077 0.0424 0.0566
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0077 0.0424 0.1445
Schistosoma mansoni cathepsin D (A01 family) 0.0848 0.6827 0.6827
Giardia lamblia Cysteine protease 0.0077 0.0424 0.2851
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.1393 0.186
Echinococcus multilocularis pyruvate kinase 0.0037 0.0086 0.0115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0365 0.2815 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0077 0.0424 0.1445
Loa Loa (eye worm) hypothetical protein 0.0043 0.0143 0.0191
Trypanosoma cruzi cysteine proteinase, putative 0.0194 0.1393 0.3619
Trypanosoma cruzi cysteine proteinase, putative 0.0194 0.1393 0.3619
Echinococcus granulosus pyruvate kinase 0.0037 0.0086 0.0115
Schistosoma mansoni hypothetical protein 0.0061 0.0292 0.0292
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0288 0.2172 0.2172
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0143 0.0994
Entamoeba histolytica cysteine protease, putative 0.0365 0.2815 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0199 0.1437 0.4342
Echinococcus granulosus cathepsin L cysteine protease 0.0194 0.1393 0.186
Echinococcus granulosus cathepsin l1 0.0365 0.2815 0.3756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Plasmodium falciparum serine repeat antigen 5 0.0077 0.0424 0.1445
Echinococcus multilocularis cathepsin L cysteine protease 0.0365 0.2815 0.3756
Trypanosoma cruzi cysteine peptidase, putative 0.0365 0.2815 0.7552
Schistosoma mansoni cathepsin F (C01 family) 0.0248 0.1846 0.1846
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0143 0.044
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0424 0.1445
Brugia malayi cathepsin B-like cysteine proteinase 0.0472 0.3699 0.4936
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0077 0.0424 0.2851
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0424 0.1445
Plasmodium vivax aspartyl protease, putative 0.0068 0.0347 0.1169
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0143 0.044
Brugia malayi Cathepsin L-like cysteine proteinase 0.0248 0.1846 0.2463
Giardia lamblia Pyruvate kinase 0.0037 0.0086 0.0461
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0086 0.0305
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0143 0.044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0143 0.0143
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0493 0.3878 0.5175
Entamoeba histolytica cysteine proteinase 2 0.0194 0.1393 0.4913
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0143 0.044
Brugia malayi Papain family cysteine protease containing protein 0.0077 0.0424 0.0566
Brugia malayi cathepsin L-like precursor 0.0248 0.1846 0.2463
Schistosoma mansoni cathepsin s 0.0117 0.0751 0.0751
Plasmodium vivax vivapain-2 0.0365 0.2815 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0299 0.0398
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0192 0.0294
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0194 0.1393 0.3619
Plasmodium falciparum serine repeat antigen 1 0.0077 0.0424 0.1445
Echinococcus granulosus geminin 0.0205 0.1482 0.1978
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.3198 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.053 0.0707
Schistosoma mansoni cathepsin S (C01 family) 0.0077 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0292 0.097
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0143 0.0191
Mycobacterium tuberculosis Conserved protein 0.0043 0.0143 0.0287
Trypanosoma cruzi prefoldin subunit, putative 0.0061 0.0292 0.0569
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.3198 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0299 0.0299
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0365 0.2815 0.3756
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0424 0.0424
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0077 0.0424 0.2851
Brugia malayi Cathepsin L-like precursor 0.0365 0.2815 0.3756
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0299 0.0299
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0288 0.2172 0.7698
Schistosoma mansoni cathepsin D (A01 family) 0.0848 0.6827 0.6827
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0143 0.0287
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0928 0.7494 0.7494
Brugia malayi cathepsin F-like cysteine proteinase 0.0117 0.0751 0.1003
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0241 0.0241
Plasmodium vivax unspecified product 0.0077 0.0424 0.1445
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0077 0.0424 0.1445
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0424 0.1445
Schistosoma mansoni pyruvate kinase 0.0037 0.0086 0.0086
Echinococcus granulosus prefoldin subunit 6 0.0061 0.0292 0.0389
Brugia malayi Cathepsin L-like precursor 0.0365 0.2815 0.3756
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0143 0.0185
Toxoplasma gondii preprocathepsin c precursor, putative 0.0077 0.0424 0.1445
Brugia malayi aspartic protease BmAsp-2, identical 0.0068 0.0347 0.0463
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0424 0.1445
Echinococcus multilocularis cysteine protease 0.0365 0.2815 0.3756
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0077 0.0424 0.0566
Leishmania major cathepsin L-like protease 0.0365 0.2815 0.8768
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0472 0.3699 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0055 0.0241 0.0321
Echinococcus granulosus cathepsin l cysteine peptidase 0.0365 0.2815 0.3756
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Echinococcus multilocularis cathepsin b 0.0472 0.3699 0.4936
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0074
Echinococcus granulosus pyruvate kinase 0.0037 0.0086 0.0115
Schistosoma mansoni dopamine-beta-monooxygenase 0.0493 0.3878 0.3878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0248 0.1846 0.6532
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0143 0.0159
Entamoeba histolytica prefoldin subunit 6, putative 0.0061 0.0292 0.097
Schistosoma mansoni cathepsin B (C01 family) 0.0077 0.0424 0.0424
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0665 0.2305
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0068 0.0347 0.0463
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0143 0.044
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0143 0.044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.053 0.053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0365 0.2815 1
Trypanosoma brucei prefoldin subunit, putative 0.0061 0.0292 0.0661
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0928 0.7494 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0143 0.0191
Giardia lamblia Cathepsin L precursor 0.0077 0.0424 0.2851
Schistosoma mansoni hypothetical protein 0.0205 0.1482 0.1482
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0143 0.0159
Plasmodium falciparum plasmepsin VII 0.0068 0.0347 0.1169
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0199 0.1437 0.507
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0086 0.0115
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0347 0.0347
Entamoeba histolytica cysteine protease, putative 0.0077 0.0424 0.1445
Echinococcus multilocularis calpain A 0.0055 0.0241 0.0321
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0086 0.0115
Loa Loa (eye worm) cathepsin B 0.0199 0.1437 0.1918
Loa Loa (eye worm) fibroinase 0.0365 0.2815 0.3756
Loa Loa (eye worm) hypothetical protein 0.0248 0.1846 0.2463
Entamoeba histolytica cysteine proteinase, putative 0.0365 0.2815 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.1393 0.4913
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0077 0.0424 0.1445
Brugia malayi cathepsin Z-like cysteine proteinase 0.0077 0.0424 0.0566
Onchocerca volvulus 0.0365 0.2815 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.3198 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0365 0.2815 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.1393 0.1393
Loa Loa (eye worm) hypothetical protein 0.0061 0.0292 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.1846 0.2463
Giardia lamblia Cathepsin L precursor 0.0077 0.0424 0.2851
Brugia malayi Cathepsin L-like precursor 0.0365 0.2815 0.3756
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.053 0.0707
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0077 0.0424 0.1445
Echinococcus granulosus tachykinin peptides receptor 99D 0.0621 0.4945 0.6598
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0077 0.0424 0.1445
Giardia lamblia Cathepsin L precursor 0.0077 0.0424 0.2851
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0365 0.2815 1
Echinococcus multilocularis cathepsin b 0.0472 0.3699 0.4936
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0424 0.1445
Plasmodium vivax vivapain-2 0.0365 0.2815 1
Plasmodium falciparum plasmepsin VI 0.0288 0.2172 0.7698
Giardia lamblia Cathepsin L precursor 0.0077 0.0424 0.2851
Onchocerca volvulus 0.0365 0.2815 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0077 0.0424 0.1445
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0086 0.0115
Echinococcus multilocularis cathepsin L cysteine protease 0.0365 0.2815 0.3756
Echinococcus multilocularis cathepsin L 0.0077 0.0424 0.0566
Giardia lamblia Cathepsin B precursor 0.0199 0.1437 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0365 0.2815 1
Giardia lamblia Cathepsin L precursor 0.0077 0.0424 0.2851
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.1393 0.4913
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.1393 0.4913
Echinococcus multilocularis geminin 0.0205 0.1482 0.1978
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0665 0.0887
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0665 0.2305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.3198 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0365 0.2815 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0424 0.1445
Loa Loa (eye worm) hypothetical protein 0.0241 0.1781 0.2377
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0665 0.1859
Echinococcus granulosus cathepsin L 0.0194 0.1393 0.186
Loa Loa (eye worm) hypothetical protein 0.0365 0.2815 0.3756
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0665 0.2305
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0199 0.1437 0.374
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0192 0.0342
Echinococcus granulosus cathepsin L 0.0077 0.0424 0.0566
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0086 0.0305
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Onchocerca volvulus 0.0365 0.2815 1
Plasmodium vivax plasmepsin IV, putative 0.0288 0.2172 0.7698
Entamoeba histolytica cysteine proteinase 1, putative 0.0194 0.1393 0.4913
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0077 0.0424 0.2851
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0143 0.0287
Trypanosoma cruzi cruzipain precursor, putative 0.0411 0.3198 0.8613
Onchocerca volvulus 0.0077 0.0424 0.1508
Trypanosoma cruzi major cysteine proteinase, putative 0.0123 0.0808 0.1998
Brugia malayi 6-phosphofructokinase 0.0106 0.0665 0.0887
Loa Loa (eye worm) hypothetical protein 0.0288 0.2172 0.2898
Loa Loa (eye worm) hypothetical protein 0.0068 0.0347 0.0463
Leishmania major cathepsin L-like protease 0.0365 0.2815 0.8768
Trypanosoma cruzi cysteine peptidase, putative 0.0411 0.3198 0.8613
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0053 0.0221 0.0294
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0472 0.3699 0.3699
Schistosoma mansoni microtubule-associated protein tau 0.0756 0.6064 0.6064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0365 0.2815 1
Onchocerca volvulus 0.0365 0.2815 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Toxoplasma gondii cathepsin B 0.0199 0.1437 0.507
Loa Loa (eye worm) hypothetical protein 0.0077 0.0424 0.0566
Leishmania major cathepsin L-like protease 0.0365 0.2815 0.8768
Brugia malayi phosphofructokinase 0.0106 0.0665 0.0887
Toxoplasma gondii ABC1 family protein 0.0043 0.0143 0.044
Loa Loa (eye worm) hypothetical protein 0.0472 0.3699 0.4936
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0077 0.0424 0.1445
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0665 0.2305
Plasmodium falciparum serine repeat antigen 9 0.0077 0.0424 0.1445
Brugia malayi Cathepsin L-like precursor 0.0248 0.1846 0.2463
Giardia lamblia Cathepsin B precursor 0.0077 0.0424 0.2851
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0928 0.7494 1
Plasmodium falciparum plasmepsin III 0.0068 0.0347 0.1169
Entamoeba histolytica cysteine protease, putative 0.0194 0.1393 0.4913
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0347 0.0347
Mycobacterium tuberculosis Conserved protein 0.0043 0.0143 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0077 0.0424 0.1445
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0365 0.2815 0.3756
Trypanosoma cruzi cruzipain precursor, putative 0.0117 0.0751 0.1841
Echinococcus granulosus microtubule associated protein 2 0.0756 0.6064 0.8092
Onchocerca volvulus 0.0033 0.0055 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0077 0.0424 0.1445
Giardia lamblia Cathepsin B precursor 0.0077 0.0424 0.2851
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.3198 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0143 0.0994
Plasmodium falciparum plasmepsin I 0.0288 0.2172 0.7698
Loa Loa (eye worm) hypothetical protein 0.0049 0.0192 0.0257
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0755 0.1008
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0665 0.2305
Loa Loa (eye worm) hypothetical protein 0.0077 0.0424 0.0566
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.1393 0.4913
Mycobacterium ulcerans hypothetical protein 0.0043 0.0143 0.0994
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0068 0.0347 0.1169
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0077 0.0424 0.0424
Plasmodium vivax aspartyl proteinase, putative 0.0068 0.0347 0.1169
Giardia lamblia Hypothetical protein 0.0077 0.0424 0.2851
Entamoeba histolytica cysteine protease, putative 0.0077 0.0424 0.1445
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0077 0.0424 0.1445
Plasmodium falciparum serine repeat antigen 7 0.0077 0.0424 0.1445
Echinococcus multilocularis pyruvate kinase 0.0029 0.0022 0.0029
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0086 0.0234
Mycobacterium ulcerans beta-lactamase 0.0043 0.0143 0.0994
Giardia lamblia Cathepsin L precursor 0.0077 0.0424 0.2851
Brugia malayi MH2 domain containing protein 0.0117 0.0755 0.1008
Echinococcus multilocularis pyruvate kinase 0.0037 0.0086 0.0115
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0086 0.0115
Plasmodium vivax vivapain-3 0.0194 0.1393 0.4913
Plasmodium falciparum serine repeat antigen 3 0.0077 0.0424 0.1445
Onchocerca volvulus 0.0068 0.0347 0.1233
Onchocerca volvulus 0.0068 0.0347 0.1233
Brugia malayi Cathepsin L-like precursor 0.0365 0.2815 0.3756
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.0105 0.014
Plasmodium vivax aspartyl proteinase, putative 0.0288 0.2172 0.7698
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0365 0.2815 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0365 0.2815 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0365 0.2815 1
Schistosoma mansoni cathepsin C 0.0077 0.0424 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.3198 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0411 0.3198 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0299 0.0398
Onchocerca volvulus 0.0043 0.0143 0.051
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0117 0.0751 0.1003
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0143 0.0191
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0068 0.0347 0.0347
Schistosoma mansoni peptidylglycine monooxygenase 0.0493 0.3878 0.3878
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0665 0.1601
Echinococcus multilocularis cathepsin L 0.0194 0.1393 0.186
Entamoeba histolytica cysteine protease, putative 0.0077 0.0424 0.1445
Brugia malayi Cathepsin L-like precursor 0.0117 0.0751 0.1003
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0086 0.0234
Giardia lamblia Cathepsin L-like protease 0.0077 0.0424 0.2851
Brugia malayi RNA binding protein 0.0062 0.0299 0.0398
Loa Loa (eye worm) hypothetical protein 0.0077 0.0424 0.0566
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.053 0.0707
Loa Loa (eye worm) hypothetical protein 0.0928 0.7494 1
Entamoeba histolytica cysteine protease, putative 0.0077 0.0424 0.1445
Schistosoma mansoni cathepsin F (C01 family) 0.0365 0.2815 0.2815
Loa Loa (eye worm) RNA binding protein 0.0062 0.0299 0.0398
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0143 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0365 0.2815 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0365 0.2815 0.3756
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0295 0.2229 0.5931
Entamoeba histolytica cysteine protease, putative 0.0077 0.0424 0.1445
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0077 0.0424 0.1445
Brugia malayi cathepsin L-like cysteine proteinase 0.0077 0.0424 0.0566
Giardia lamblia Encystation-specific protease 0.0077 0.0424 0.2851
Mycobacterium tuberculosis Conserved protein 0.0043 0.0143 0.0287
Giardia lamblia Cathepsin B precursor 0.0077 0.0424 0.2851
Onchocerca volvulus Cathepsin L homolog 0.0365 0.2815 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0472 0.3699 0.3699
Loa Loa (eye worm) cysteine protease 0.0365 0.2815 0.3756
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.053 0.053
Brugia malayi calpain family protein 1 0.0053 0.0221 0.0294
Loa Loa (eye worm) hypothetical protein 0.0493 0.3878 0.5175
Loa Loa (eye worm) hypothetical protein 0.0043 0.0143 0.0191

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 89.772 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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