TDR Targets

Basic information

Technical information

TDR Targets ID: 1413892
Name: (3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyrimidin -7-yl)methyl 3-[[2-(4-methylphenoxy)acetyl]am ino]benzoate
MW: 463.506 | Formula: C24H21N3O5S
H donors: 1 H acceptors: 3 LogP: 3.15 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccc(c1)C(=O)OCc1cc(=O)n2c(n1)scc2C)COc1ccc(cc1)C
InChi: 1S/C24H21N3O5S/c1-15-6-8-20(9-7-15)31-13-21(28)25-18-5-3-4-17(10-18)23(30)32-12-19-11-22(29)27-16(2)14-33-24(27)26-19/h3-11,14H,12-13H2,1-2H3,(H,25,28)
InChiKey: AHMOSGSIHBRTJU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-7-yl)methyl 3-[[2-(4-methylphenoxy)acetyl]amino]benzoate
3-[[2-(4-methylphenoxy)-1-oxoethyl]amino]benzoic acid (3-methyl-5-oxo-7-thiazolo[3,2-a]pyrimidinyl)methyl ester
3-[[2-(4-methylphenoxy)acetyl]amino]benzoic acid (5-keto-3-methyl-thiazolo[3,2-a]pyrimidin-7-yl)methyl ester
(3-methyl-5-oxo-[1,3]thiazolo[3,2-a]pyrimidin-7-yl)methyl 3-[2-(4-methylphenoxy)ethanoylamino]benzoate
G357-1857
NCGC00130517-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Photinus pyralis	Luciferin 4-monooxygenase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania donovani	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Onchocerca volvulus		Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania donovani	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium vivax	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Mycobacterium ulcerans	fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Entamoeba histolytica	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Mycobacterium ulcerans	fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Entamoeba histolytica	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium berghei	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Entamoeba histolytica	acyl-coA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium knowlesi	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium falciparum	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania braziliensis	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium yoelii	peroxisomal-coenzyme a synthetase	Get druggable targets OG5_126609	All targets in OG5_126609

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD9	Luciferin 4-monooxygenase	550 aa	463 aa	21.8 %
Mycobacterium leprae	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	461 aa	22.3 %
Trypanosoma cruzi	fatty acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	482 aa	24.7 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	526 aa	21.9 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	539 aa	19.1 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	542 aa	23.8 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	497 aa	19.3 %
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	Luciferin 4-monooxygenase	550 aa	502 aa	22.5 %
Neospora caninum	Short-chain dehydrogenase/reductase SDR, related	Luciferin 4-monooxygenase	550 aa	518 aa	19.1 %
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	Luciferin 4-monooxygenase	550 aa	476 aa	22.5 %
Onchocerca volvulus	Lysine-specific histone demethylase 1A homolog	Luciferin 4-monooxygenase	550 aa	550 aa	22.5 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	530 aa	23.8 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	18.3 %
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	Luciferin 4-monooxygenase	550 aa	509 aa	21.8 %
Leishmania donovani	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	500 aa	23.4 %
Trypanosoma brucei	fatty acyl CoA synthetase 3	Luciferin 4-monooxygenase	550 aa	491 aa	23.6 %
Loa Loa (eye worm)	AMP-binding enzyme family protein	Luciferin 4-monooxygenase	550 aa	489 aa	23.3 %
Mycobacterium ulcerans	putative fatty-acid--CoA ligase	Luciferin 4-monooxygenase	550 aa	576 aa	20.8 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	478 aa	21.1 %
Babesia bovis	fatty acyl-CoA synthetase family protein	Luciferin 4-monooxygenase	550 aa	461 aa	23.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	499 aa	19.2 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	507 aa	20.9 %
Schistosoma japonicum	ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative	Luciferin 4-monooxygenase	550 aa	501 aa	24.6 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	617 aa	22.2 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	493 aa	20.7 %
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	496 aa	24.2 %
Leishmania mexicana	acetyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	559 aa	20.6 %
Trypanosoma brucei gambiense	fatty acyl CoA synthetase 4, putative	Luciferin 4-monooxygenase	550 aa	497 aa	23.7 %
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	480 aa	22.5 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.6 %
Echinococcus granulosus	long chain fatty acid coenzyme A ligase 1	Luciferin 4-monooxygenase	550 aa	452 aa	26.1 %
Echinococcus multilocularis	long chain fatty acid transport protein 4	Luciferin 4-monooxygenase	550 aa	476 aa	22.3 %
Trichomonas vaginalis	long-chain-fatty-acid CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	490 aa	23.3 %
Theileria parva	long-chain fatty acid CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	507 aa	23.5 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	442 aa	23.5 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	526 aa	22.4 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase FadD15	Luciferin 4-monooxygenase	550 aa	484 aa	26.0 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	593 aa	22.1 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	539 aa	22.1 %
Onchocerca volvulus		Luciferin 4-monooxygenase	550 aa	487 aa	23.8 %
Dictyostelium discoideum	fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	462 aa	23.8 %
Cryptosporidium hominis	acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme)	Luciferin 4-monooxygenase	550 aa	549 aa	22.6 %
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	Luciferin 4-monooxygenase	550 aa	509 aa	22.6 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	545 aa	24.9 %
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	Luciferin 4-monooxygenase	550 aa	558 aa	20.1 %
Trypanosoma cruzi	fatty acyl CoA synthetase 2, putative	Luciferin 4-monooxygenase	550 aa	495 aa	22.6 %
Toxoplasma gondii	propionate-CoA ligase	Luciferin 4-monooxygenase	550 aa	550 aa	21.1 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	529 aa	22.3 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	517 aa	24.8 %
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	Luciferin 4-monooxygenase	550 aa	493 aa	22.1 %
Leishmania infantum	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	500 aa	23.4 %
Mycobacterium leprae	FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Luciferin 4-monooxygenase	550 aa	533 aa	22.7 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	601 aa	22.5 %
Onchocerca volvulus	Matrilysin homolog	Luciferin 4-monooxygenase	550 aa	466 aa	24.2 %
Leishmania braziliensis	acetyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	596 aa	21.1 %
Trichomonas vaginalis	antibiotic synthetase, putative	Luciferin 4-monooxygenase	550 aa	581 aa	21.2 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	543 aa	24.5 %
Trypanosoma brucei gambiense	fatty acyl CoA synthetase 3	Luciferin 4-monooxygenase	550 aa	491 aa	23.6 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	22.1 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	531 aa	19.0 %
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	480 aa	21.5 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	535 aa	22.6 %
Leishmania major	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	482 aa	23.2 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	586 aa	24.4 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase, FadD11	Luciferin 4-monooxygenase	550 aa	492 aa	24.6 %
Mycobacterium ulcerans	non-ribosomal peptide synthetase	Luciferin 4-monooxygenase	550 aa	541 aa	22.4 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase FadD15	Luciferin 4-monooxygenase	550 aa	482 aa	24.3 %
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	476 aa	20.8 %
Cryptosporidium parvum	putative long chain fatty acyl CoA synthetase having a signal peptide	Luciferin 4-monooxygenase	550 aa	472 aa	24.8 %
Leishmania braziliensis	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	496 aa	22.8 %
Babesia bovis	long-chain acyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	445 aa	21.8 %
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	Luciferin 4-monooxygenase	550 aa	536 aa	24.4 %
Schistosoma japonicum	ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative	Luciferin 4-monooxygenase	550 aa	466 aa	27.3 %
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	505 aa	28.1 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	558 aa	20.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	463 aa	23.5 %
Neospora caninum	acetyl-coenzyme a synthetase, putative	Luciferin 4-monooxygenase	550 aa	549 aa	20.9 %
Entamoeba histolytica	acyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	446 aa	22.0 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	538 aa	21.8 %
Dictyostelium discoideum	fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	501 aa	24.4 %
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	Luciferin 4-monooxygenase	550 aa	535 aa	23.2 %
Trichomonas vaginalis	AMP dependent ligase, putative	Luciferin 4-monooxygenase	550 aa	445 aa	26.1 %
Leishmania braziliensis	long-chain-fatty-acid-CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	504 aa	25.6 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	522 aa	19.9 %
Echinococcus granulosus	long chain fatty acid transport protein 4	Luciferin 4-monooxygenase	550 aa	476 aa	22.3 %
Candida albicans	similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase	Luciferin 4-monooxygenase	550 aa	478 aa	23.4 %
Leishmania mexicana	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	483 aa	23.8 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.6 %
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	494 aa	23.9 %
Echinococcus granulosus	long chain fatty acid coenzyme A ligase 5	Luciferin 4-monooxygenase	550 aa	458 aa	25.8 %
Schistosoma japonicum	ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative	Luciferin 4-monooxygenase	550 aa	541 aa	22.4 %
Dictyostelium discoideum	acetyl-CoA ligase	Luciferin 4-monooxygenase	550 aa	549 aa	22.2 %
Trypanosoma cruzi	fatty acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	480 aa	25.2 %
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	496 aa	24.2 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	484 aa	20.5 %
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD11	Luciferin 4-monooxygenase	550 aa	498 aa	23.5 %
Cryptosporidium hominis	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	460 aa	26.1 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 1	Luciferin 4-monooxygenase	550 aa	443 aa	26.4 %
Cryptosporidium parvum	acetyl-coenzyme A synthetase	Luciferin 4-monooxygenase	550 aa	545 aa	22.8 %
Cryptosporidium parvum	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	460 aa	25.7 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	494 aa	24.3 %
Toxoplasma gondii	type I fatty acid synthase, putative	Luciferin 4-monooxygenase	550 aa	514 aa	19.8 %
Mycobacterium tuberculosis	Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase)	Luciferin 4-monooxygenase	550 aa	592 aa	20.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	535 aa	21.7 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	524 aa	24.0 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 5	Luciferin 4-monooxygenase	550 aa	458 aa	25.5 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	554 aa	24.4 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	560 aa	21.4 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	539 aa	22.1 %
Trichomonas vaginalis	antibiotic synthetase, putative	Luciferin 4-monooxygenase	550 aa	577 aa	22.2 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	539 aa	19.1 %
Leishmania braziliensis	acetyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	603 aa	22.6 %
Mycobacterium leprae	PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Luciferin 4-monooxygenase	550 aa	565 aa	22.8 %
Mycobacterium leprae	Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Luciferin 4-monooxygenase	550 aa	484 aa	23.3 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	522 aa	19.9 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	18.3 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	475 aa	21.1 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	550 aa	20.9 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.4 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 1	Luciferin 4-monooxygenase	550 aa	459 aa	27.0 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	492 aa	23.6 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	AMP-binding enzyme family protein	Luciferin 4-monooxygenase	550 aa	497 aa	24.7 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	476 aa	23.5 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	504 aa	22.6 %
Trypanosoma congolense	fatty acyl CoA synthetase 2, putative	Luciferin 4-monooxygenase	550 aa	500 aa	22.4 %
Trichomonas vaginalis	long-chain-fatty-acid CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	466 aa	21.7 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity.	Luciferin 4-monooxygenase	550 aa	487 aa	22.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	22.1 %
Brugia malayi	AMP-binding enzyme family protein	Luciferin 4-monooxygenase	550 aa	544 aa	21.5 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	582 aa	22.3 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	576 aa	19.8 %
Onchocerca volvulus		Luciferin 4-monooxygenase	550 aa	502 aa	24.9 %
Schistosoma mansoni	FAA1 Long-chain-fatty-acid--CoA ligase 1	Luciferin 4-monooxygenase	550 aa	494 aa	26.3 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	527 aa	25.0 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	554 aa	22.9 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	543 aa	24.5 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	538 aa	21.8 %
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	537 aa	20.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0011	0.001	0.0011
Echinococcus multilocularis	lamin dm0	0.0033	0.0109	0.0121
Brugia malayi	neuropeptide F receptor	0.0011	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0045	0.0045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Schistosoma mansoni	biogenic amine receptor	0.0011	0.001	0.0011
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0029	0.0091	0.1183
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0011	0.001	0.0011
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0011	0.001	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.001	0.0011
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.0453	0.8837
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0176	1
Echinococcus granulosus	g-protein coupled receptor	0.0011	0.001	0.0011
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.1977	0.8991	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0011	0.001	0.001
Schistosoma mansoni	histamine h1 receptor	0.0011	0.001	0.0011
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0045	0.0033
Leishmania major	DNA polymerase eta, putative	0.0019	0.0047	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0235	0.0235
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0109	0.0109
Trichomonas vaginalis	set domain proteins, putative	0.0237	0.1042	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0011	0.001	0.0011
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.001	0.0011
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0045	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0519	0.233	0.2591
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0029	0.0091	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0047	0.0036
Echinococcus granulosus	g protein coupled receptor	0.0011	0.001	0.0011
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0047	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0045	0.419
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.001	0.0011
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0011	0.001	0.001
Schistosoma mansoni	amine GPCR	0.0011	0.001	0.0011
Schistosoma mansoni	amine GPCR	0.0011	0.001	0.0011
Plasmodium falciparum	acyl-CoA synthetase	0.0021	0.0058	0.3294
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.0453	0.8837
Brugia malayi	Dopamine receptor protein 1	0.0011	0.001	0.001
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.0453	0.8837
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0045	0.0045
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.031	0.031
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0091	0.0091
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0091	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0091	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0011	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Brugia malayi	G-protein coupled receptor	0.0011	0.001	0.001
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0053	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0053	0.0371
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0047	0.0047
Schistosoma mansoni	neuropeptide receptor	0.0011	0.001	0.0011
Echinococcus multilocularis	G protein coupled receptor 139	0.0011	0.001	0.0011
Trypanosoma brucei	unspecified product	0.0013	0.002	0.0009
Leishmania major	trypanothione reductase	0.0047	0.0176	0.0165
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0053	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Echinococcus granulosus	somatostatin receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Echinococcus multilocularis	g-protein coupled receptor	0.0011	0.001	0.0011
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Brugia malayi	putative neuropeptide receptor	0.0011	0.001	0.001
Loa Loa (eye worm)	melatonin receptor type 1A	0.0011	0.001	0.001
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.004	0.004
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0011	0.001	0.0011
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0176	0.0196
Echinococcus multilocularis	neuropeptide receptor A26	0.0011	0.001	0.0011
Echinococcus multilocularis	orexin receptor type 2	0.0011	0.001	0.0011
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0056	0.0434
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0035	0.0229
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0015	0.0015
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Brugia malayi	GnHR receptor homolog	0.0011	0.001	0.001
Onchocerca volvulus		0.0237	0.1042	0.1149
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.0453	0.8837
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0237	0.1045	0.1045
Schistosoma mansoni	hypothetical protein	0.0019	0.0047	0.0053
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.031	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0019	0.0047	0.0053
Onchocerca volvulus		0.0047	0.0177	0.0186
Trypanosoma brucei	C-8 sterol isomerase, putative	0.2198	1	1
Brugia malayi	ORL1-like opioid receptor	0.0011	0.001	0.001
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0035	0.0659
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0035	0.0024
Echinococcus granulosus	serotonin receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.031	0.031
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0035	0.0024
Echinococcus granulosus	geminin	0.0336	0.1496	0.1664
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0047	0.0047
Schistosoma mansoni	ap endonuclease	0.0019	0.0045	0.005
Plasmodium falciparum	glutathione reductase	0.0047	0.0176	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Mycobacterium ulcerans	hypothetical protein	0.0029	0.0091	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0011	0.001	0.0011
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0047	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0097	0.0108
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.001	0.0011
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0056	0.0056
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0176	0.2985
Brugia malayi	larval opioid receptor	0.0011	0.001	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Echinococcus granulosus	lamin dm0	0.0033	0.0109	0.0121
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0047	0.0053
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.001	0.0011
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0035	0.0024
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.001	0.0011
Brugia malayi	hypothetical protein	0.0011	0.001	0.001
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0047	0.2137
Brugia malayi	sulfakinin receptor protein	0.0011	0.001	0.001
Echinococcus granulosus	orexin receptor type 2	0.0011	0.001	0.0011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0029	0.0091	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0047	0.0036
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0035	0.7467
Schistosoma mansoni	lamin	0.0033	0.0109	0.0121
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0047	0.0052
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0035	0.0039
Brugia malayi	hypothetical protein	0.0011	0.001	0.001
Echinococcus multilocularis	somatostatin receptor	0.0011	0.001	0.0011
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.001	0.0011
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0176	0.0196
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.001	0.0011
Brugia malayi	hypothetical protein	0.0011	0.001	0.001
Echinococcus granulosus	tm gpcr rhodopsin	0.0519	0.233	0.2591
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0058	0.0484
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.001	0.0011
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0091	0.008
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0047	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0045	0.0033
Echinococcus multilocularis	neuropeptide s receptor	0.0011	0.001	0.0011
Brugia malayi	Pre-SET motif family protein	0.0208	0.0911	0.0911
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0047	0.0345
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0011	0.001	0.0011
Plasmodium vivax	acyl-CoA synthetase, putative	0.0021	0.0058	0.2172
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.001	0.0011
Brugia malayi	follicle stimulating hormone receptor	0.0237	0.1045	0.1045
Loa Loa (eye worm)	hypothetical protein	0.006	0.0233	0.0233
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.001	0.0011
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0045	0.005
Schistosoma mansoni	hypothetical protein	0.0336	0.1496	0.1664
Echinococcus multilocularis	dro:myosuppressin receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Brugia malayi	G protein-coupled receptor F59B2.13	0.0011	0.001	0.001
Echinococcus granulosus	lamin	0.0033	0.0109	0.0121
Schistosoma mansoni	myosin xvIII	0.0011	0.001	0.0011
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0035	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0108	0.0453	0.8681
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0097	0.0108
Echinococcus granulosus	vesicular acetylcholine transporter	0.1977	0.8991	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.031	0.031
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.001	0.0011
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0235	0.0235
Trypanosoma brucei	unspecified product	0.0019	0.0047	0.0036
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.002	0.0009
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0015	0.0015
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.001	0.001
Echinococcus granulosus	tar DNA binding protein	0.0076	0.031	0.0345
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0011	0.001	0.0011
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0035	0.0024
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0011	0.001	0.0011
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.3766	0.4189
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0045	0.1303
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0106	0.0106
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0176	0.0176
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0045	0.0033
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0056	0.0063
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0056	0.0056
Echinococcus granulosus	neuropeptide receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Echinococcus multilocularis	geminin	0.0336	0.1496	0.1664
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0109	0.0109
Brugia malayi	Thioredoxin reductase	0.0047	0.0176	0.0176
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Loa Loa (eye worm)	hypothetical protein	0.003	0.0097	0.0097
Loa Loa (eye worm)	TYRA-2 protein	0.0011	0.001	0.001
Entamoeba histolytica	acyl-coA synthetase, putative	0.0029	0.0091	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.001	0.0011
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0011	0.001	0.001
Brugia malayi	TAR-binding protein	0.0076	0.031	0.031
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0047	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.002	0.0009
Echinococcus granulosus	G protein coupled receptor 139	0.0011	0.001	0.0011
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0035	0.0035
Mycobacterium tuberculosis	Probable reductase	0.0108	0.0453	0.8837
Echinococcus granulosus	fmrfamide receptor	0.0011	0.001	0.0011
Schistosoma mansoni	adenoreceptor	0.0011	0.001	0.0011
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0091	0.008
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0035	0.1997
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0047	0.0253
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0109	0.0121
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.001	0.0011
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.2198	1	1
Brugia malayi	G protein-coupled receptor	0.0011	0.001	0.001
Schistosoma mansoni	growth hormone secretagogue receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0029	0.0091	1
Onchocerca volvulus		0.003	0.0097	0.0096
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0045	0.255
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0045	0.9531
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0011	0.001	0.001
Schistosoma mansoni	biogenic amine receptor	0.0011	0.001	0.0011
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.001	0.0011
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0091	0.008
Echinococcus granulosus	g protein coupled receptor	0.0011	0.001	0.0011
Schistosoma mansoni	blooms syndrome DNA helicase	0.0017	0.0036	0.004
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0035	0.0024
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0091
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0047	0.4469
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0011	0.001	0.0011
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0177	0.0177
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0035	0.1997
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0035	0.0024
Brugia malayi	RE15519p	0.0011	0.001	0.001
Brugia malayi	hypothetical protein	0.0011	0.001	0.001
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0058	0.0058
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0011	0.001	0.0011
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0011	0.001	0.0011
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0035	0.0024
Brugia malayi	RNA binding protein	0.0076	0.031	0.031
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0056	0.0434
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0035	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.001	0.0011
Echinococcus granulosus	dna polymerase eta	0.0019	0.0047	0.0052
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.0911	0.0911
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.031	0.0345
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0091	0.0091
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.001	0.001
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0058	0.0058
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0011	0.001	0.0011
Schistosoma mansoni	opsin-like receptor	0.0011	0.001	0.0011
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0035	0.0024
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.1024	0.1139
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.001	0.0011
Echinococcus multilocularis	lamin	0.0033	0.0109	0.0121
Echinococcus granulosus	7tm_1 domain containing protein	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Echinococcus granulosus	g protein coupled receptor	0.0011	0.001	0.0011
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0045	0.005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.001	0.0011
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.0453	0.8837
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.3766	0.4189
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0091
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0047	0.0053
Echinococcus granulosus	hypothetical protein	0.0011	0.001	0.0011
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0176	0.0176
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0045	0.0323
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.001	0.0011
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0045	0.1741
Echinococcus multilocularis	musashi	0.0033	0.0109	0.0121
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0047	0.0052
Echinococcus granulosus	tumor protein p63	0.0408	0.1824	0.2029
Echinococcus multilocularis	tumor protein p63	0.0408	0.1824	0.2029
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0091	0.0091
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0011	0.001	0.0011
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.001	0.0011
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0047	0.0052
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0233	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0029	0.0029
Echinococcus granulosus	dro:myosuppressin receptor	0.0011	0.001	0.0011
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0011	0.001	0.0011
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0021	0.0058	0.4089
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0047	0.0036
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0035	0.0024
Schistosoma mansoni	hypothetical protein	0.0041	0.0148	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.001	0.0011
Onchocerca volvulus		0.006	0.0233	0.0248
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0011	0.001	0.0011
Schistosoma mansoni	opsin-like receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0035	0.1997
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.031	0.0345
Onchocerca volvulus		0.0033	0.0109	0.011
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0091	1
Echinococcus multilocularis	serotonin receptor	0.0011	0.001	0.0011
Echinococcus granulosus	neuropeptide FF receptor 2	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0029	0.0091	0.1183
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.001	0.0011
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0047	0.0053
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.001	0.0011
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.2198	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0011	0.001	0.0011
Schistosoma mansoni	biogenic amine receptor	0.0011	0.001	0.0011
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.001	0.0011
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0047	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0037	0.0037
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0035	0.0024
Schistosoma mansoni	amine GPCR	0.0011	0.001	0.0011
Schistosoma mansoni	hypothetical protein	0.0011	0.001	0.0011
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0177	0.0197
Echinococcus granulosus	allatostatin A receptor	0.0011	0.001	0.0011
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0035	0.0024
Brugia malayi	intermediate filament protein	0.0033	0.0109	0.0109
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Brugia malayi	putative neuropeptide receptor NPR1	0.0011	0.001	0.001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0097	0.0108
Brugia malayi	Serotonin receptor	0.0011	0.001	0.001
Schistosoma mansoni	neuropeptide receptor	0.0011	0.001	0.0011
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0047	0.0052
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0047	0.0053
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.001	0.0011
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0045	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0045	0.005
Brugia malayi	hypothetical protein	0.0011	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.004	0.004
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.006	0.0235	0.0235
Plasmodium vivax	SET domain protein, putative	0.003	0.0097	0.473
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0035	0.0659
Brugia malayi	neuropeptide F receptor	0.0011	0.001	0.001
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0029	0.0091	1
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Schistosoma mansoni	lamin	0.0033	0.0109	0.0121
Trypanosoma brucei	trypanothione reductase	0.0047	0.0176	0.0165
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0097	0.0108
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0047	0.0053
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.001	0.0011
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0047	0.0052
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.001	0.0011
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0092	0.0102
Brugia malayi	Serotonin receptor	0.0011	0.001	0.001
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.00000000001804	0.000000001023
Brugia malayi	glutathione reductase	0.0047	0.0176	0.0176
Schistosoma mansoni	hypothetical protein	0.0047	0.0177	0.0197
Echinococcus multilocularis	allatostatin A receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	RNA binding protein	0.0076	0.031	0.031
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0097	0.0108
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0035	0.0024
Schistosoma mansoni	amine GPCR	0.0011	0.001	0.0011
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0097	0.5485
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0011	0.001	0.001
Brugia malayi	hypothetical protein	0.0011	0.001	0.001
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0235	0.0235
Brugia malayi	hypothetical protein	0.0233	0.1024	0.1024
Echinococcus granulosus	intermediate filament protein	0.0033	0.0109	0.0121
Schistosoma mansoni	neuropeptide receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0058	0.0058
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0097	0.0108
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.002	0.0009
Schistosoma mansoni	hypothetical protein	0.0019	0.0047	0.0053
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0029	0.0091	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0047	0.0053
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0047	0.0047
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0011	0.001	0.0011
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0035	0.0039
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0035	0.0039
Leishmania major	C-8 sterol isomerase-like protein	0.2198	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0176	0.0165
Brugia malayi	Dopamine receptor	0.0011	0.001	0.001
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0016	0.0032	0.0036
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0047	0.0036
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0011	0.001	0.0011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.001	0.0011
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0176	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Plasmodium falciparum	glutathione reductase	0.0016	0.0035	0.1997
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0021	0.0058	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Trypanosoma brucei	unspecified product	0.0013	0.002	0.0009
Brugia malayi	hypothetical protein	0.0011	0.001	0.001
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0045	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0032	0.0032
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.001	0.0011
Schistosoma mansoni	neuropeptide f receptor 76f	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Brugia malayi	Dopamine receptor protein 2	0.0011	0.001	0.001
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0018	0.0045	0.2534
Schistosoma mansoni	hypothetical protein	0.0336	0.1496	0.1664
Echinococcus granulosus	neuropeptide s receptor	0.0011	0.001	0.0011
Schistosoma mansoni	hypothetical protein	0.0011	0.001	0.0011
Onchocerca volvulus		0.0033	0.0109	0.011
Echinococcus granulosus	neuropeptide receptor A26	0.0011	0.001	0.0011
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0011	0.001	0.0011
Echinococcus multilocularis	sex peptide receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.1124	0.5092	0.5092
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.0508	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.031	0.0345
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0011	0.001	0.0011
Schistosoma mansoni	hypothetical protein	0.0011	0.001	0.0011
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0047	0.0047
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0035	0.1997
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.001	0.0011
Schistosoma mansoni	opsin-like receptor	0.0011	0.001	0.0011
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0047	0.0036
Brugia malayi	vesicular acetylcholine transporter unc-17	0.1977	0.8991	0.8991
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0011	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0233	0.1024	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0035	0.0024
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.001	0.0011
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0035	0.0024
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.001	0.0011
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0047	0.0253
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.001	0.0011
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.1977	0.8991	0.8991
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0056	0.0063
Echinococcus multilocularis	vesicular acetylcholine transporter	0.1977	0.8991	1
Echinococcus granulosus	GPCR family 2	0.0019	0.0047	0.0053
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0176	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.0032	0.0036
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0047	0.0345
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0058	0.0058
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.0508	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0045	0.0323
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0035	0.1997
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0035	0.0024
Brugia malayi	G-protein coupled receptor	0.0011	0.001	0.001
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0176	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0011	0.001	0.001
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0047	0.0036
Onchocerca volvulus		0.0029	0.0091	0.009
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.031	0.0345
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0047	0.2137
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.001	0.0011
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.0508	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0047	0.0047
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.3766	0.4189
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0097	0.0108
Echinococcus granulosus	sex peptide receptor	0.0011	0.001	0.0011
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0011	0.001	0.0011
Brugia malayi	AKH receptor	0.0011	0.001	0.001
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0011	0.001	0.001
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0109	0.0109
Schistosoma mansoni	neuropeptide receptor	0.0011	0.001	0.0011
Brugia malayi	hypothetical protein	0.0011	0.001	0.001
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Brugia malayi	hypothetical protein	0.0011	0.001	0.001
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0029	0.0091	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0011	0.001	0.0011
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0035	0.0024
Echinococcus multilocularis	serotonin receptor	0.0011	0.001	0.0011
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.0025	0.1389
Brugia malayi	Pre-SET motif family protein	0.003	0.0097	0.0097
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0148	0.0148
Brugia malayi	hypothetical protein	0.0011	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Echinococcus granulosus	neuropeptide receptor	0.0011	0.001	0.0011
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.0508	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0091
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.001	0.0011
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0045	0.0033
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.001	0.0011
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0053	0.0371
Schistosoma mansoni	amine GPCR	0.0011	0.001	0.0011
Schistosoma mansoni	vesicular acetylcholine transporter	0.1977	0.8991	1
Brugia malayi	Melatonin receptor type 1A	0.0011	0.001	0.001
Toxoplasma gondii	exonuclease III APE	0.0019	0.0045	0.255
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.1024	0.1139
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.031	0.0345
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0251 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 0.5012 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	5.3582 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1552571

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1413892