Detailed information for compound 1415275

Basic information

Technical information
  • TDR Targets ID: 1415275
  • Name: N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)py ridine-4-carboxamide
  • MW: 234.278 | Formula: C10H10N4OS
  • H donors: 0 H acceptors: 4 LogP: 1.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nnc(s1)N(C(=O)c1ccncc1)C
  • InChi: 1S/C10H10N4OS/c1-7-12-13-10(16-7)14(2)9(15)8-3-5-11-6-4-8/h3-6H,1-2H3
  • InChiKey: UPHDADLJKGJPNS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-pyridinecarboxamide
  • N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)isonicotinamide
  • ZINC01349010
  • MLS000856795
  • SMR000278740
  • ASN 09114538
  • N-Methyl-N-(5-methyl-[1,3,4]thiadiazol-2-yl)-isonicotinamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0128 0.0128
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0832 0.4268 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0034 0.0079
Onchocerca volvulus 0.0036 0.0114 0.0235
Toxoplasma gondii microneme protein MIC2 0.0036 0.0114 0.0892
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.1315 0.1315
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0047 0.0047
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0276 0.5708
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Entamoeba histolytica hypothetical protein 0.0039 0.0128 0.2634
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0009 0.002
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0128 0.03
Onchocerca volvulus 0.0036 0.0114 0.0235
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0128 0.0229
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0047 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Chlamydia trachomatis endonuclease IV 0.0078 0.0332 1
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0036 0.0114 0.0114
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1469 0.3399
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0055 0.041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0128 0.0297
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0481
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0081 0.0191
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0115 0.2313
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1931 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0009 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0081 0.0081
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0081 0.0191
Entamoeba histolytica hypothetical protein 0.0039 0.0128 0.2634
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0479 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0069 0.0159
Loa Loa (eye worm) hypothetical protein 0.023 0.1128 0.2644
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0095 0.0159
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0009 0.002
Brugia malayi nuclear receptor RXR 0.0016 0.0009 0.002
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0276 0.0647
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0134 0.0134
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0047 0.0805
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Brugia malayi hypothetical protein 0.0245 0.1203 0.2818
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0129 0.0129
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0128 0.03
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0081 0.0188
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0225 0.0225
Toxoplasma gondii aldehyde dehydrogenase 0.0251 0.1235 1
Echinococcus multilocularis musashi 0.0082 0.0356 0.0356
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0081 0.0081
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0479 0.0479
Brugia malayi Pre-SET motif family protein 0.0832 0.4268 1
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.2136 0.2136
Echinococcus granulosus lamin 0.0082 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0479 0.0953
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0139 0.1001
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.024 0.1181 0.2733
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0479 0.111
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0157 0.0368
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0128 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Onchocerca volvulus 0.012 0.0553 0.1136
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0139 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0077 0.0584
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0095 0.1877
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0079
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0139 0.1707
Toxoplasma gondii endonuclease IV APN 0.0078 0.0332 0.2663
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0356 0.0835
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0009 0.002
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0276 0.5734
Echinococcus multilocularis cpg binding protein 0.0031 0.0091 0.0091
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0115 0.0115
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0115 0.0267
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0069 0.134
Onchocerca volvulus 0.0036 0.0114 0.0235
Echinococcus granulosus dnaJ subfamily B 0.0423 0.2136 0.2136
Loa Loa (eye worm) hypothetical protein 0.0081 0.0348 0.0817
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.1129 0.2645
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0128 0.0297
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Schistosoma mansoni serine-rich repeat protein 0.0454 0.2293 0.5307
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0034 0.0034
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0081 0.0191
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0128 0.0297
Schistosoma mansoni hypothetical protein 0.0454 0.2293 0.5307
Entamoeba histolytica hypothetical protein 0.0039 0.013 0.2664
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0103 0.2064
Toxoplasma gondii exonuclease III APE 0.0041 0.0139 0.1093
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Onchocerca volvulus 0.0036 0.0114 0.0235
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0128 0.03
Onchocerca volvulus 0.0947 0.4867 1
Schistosoma mansoni cpg binding protein 0.0031 0.0091 0.0211
Brugia malayi follicle stimulating hormone receptor 0.023 0.1129 0.2645
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0081 0.0081
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0069 0.1183
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0479 0.1123
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0081 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0081 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0081 0.0191
Plasmodium vivax SET domain protein, putative 0.012 0.0553 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0034 0.0136
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0011
Onchocerca volvulus 0.0015 0.0005 0.001
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0276 0.1929
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0479 1
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0078 0.0332 0.0778
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0479 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0009 0.002
Echinococcus granulosus leukotriene A 4 hydrolase 0.024 0.1181 0.1181
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0114 0.0268
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0081 0.0188
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1235 1
Brugia malayi Kringle domain containing protein 0.0023 0.0047 0.011
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0049 0.0112
Brugia malayi hypothetical protein 0.0039 0.013 0.0304
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0082 0.0193
Onchocerca volvulus 0.0015 0.0005 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0081 0.0191
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0081 0.0191
Entamoeba histolytica hypothetical protein 0.0036 0.0114 0.2344
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0115 0.0115
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0103 0.2114
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.004
Schistosoma mansoni rab6-interacting 0.002 0.0034 0.0078
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0016 0.0011 0.0025
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0034 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0115 0.0202
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.013 0.013
Onchocerca volvulus 0.002 0.0034 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0079
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Brugia malayi PXA domain containing protein 0.0039 0.0128 0.03
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0103 0.0476
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0108 0.0252
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0081 0.0188
Brugia malayi hypothetical protein 0.002 0.0034 0.0079
Onchocerca volvulus 0.0015 0.0005 0.001
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0103 0.0803
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0553 0.1279
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0081 0.0191
Echinococcus granulosus intermediate filament protein 0.0082 0.0356 0.0356
Entamoeba histolytica elongation factor-2 kinase, putative 0.0036 0.0114 0.2344
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.027
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0078 0.0332 0.2587
Echinococcus granulosus tumor protein p63 0.0364 0.1828 0.1828
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0115 0.0527 0.0527
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0077 0.1343
Echinococcus multilocularis thyroid hormone receptor alpha 0.0296 0.1469 0.1469
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0139 0.0326
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Onchocerca volvulus 0.0023 0.0047 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0081 0.0191
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1235 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0081 0.0191
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0095 0.0401
Loa Loa (eye worm) hypothetical protein 0.0078 0.0332 0.0778
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0115 0.027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0553 0.1279
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0081 0.0167
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0279 0.0646
Onchocerca volvulus 0.0015 0.0005 0.001
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0842 0.4321 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0069 0.134
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0077 0.0174
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0128 0.0128
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0878 0.4509 0.4509
Brugia malayi Zona pellucida-like domain containing protein 0.0036 0.0114 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Echinococcus granulosus pikachurin 0.0023 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0128 0.0128
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0205 0.0475
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0479 0.0953
Schistosoma mansoni DNA helicase recq1 0.0029 0.0081 0.0187
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0081 0.0081
Schistosoma mansoni ap endonuclease 0.0041 0.0139 0.0322
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0128 0.0128
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0251 0.1235 1
Onchocerca volvulus 0.0015 0.0005 0.001
Entamoeba histolytica hypothetical protein 0.0039 0.013 0.2664
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0205 0.0995 0.2302
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0081 0.0188
Brugia malayi hypothetical protein 0.0016 0.0009 0.002
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0081 0.0619
Schistosoma mansoni hypothetical protein 0.0266 0.1315 0.3043
Brugia malayi 6-phosphofructokinase 0.0106 0.0479 0.1123
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0115 0.0202
Echinococcus granulosus slit 2 protein 0.0023 0.0049 0.0049
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.002 0.0034 0.0078
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0172 0.0404
Schistosoma mansoni lipoxygenase 0.002 0.0034 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0047 0.0872
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0114
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0425 0.2142 0.4958
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0115 0.2313
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0276 0.0276
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0332 0.5991
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0115 0.0575
Schistosoma mansoni loxhd1 0.002 0.0034 0.0078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0127 0.0296
Onchocerca volvulus 0.0082 0.0356 0.0732
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0479 0.0953
Schistosoma mansoni ap endonuclease 0.0041 0.0139 0.0322
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0133 0.3337
Treponema pallidum hypothetical protein 0.0036 0.0114 0.0267
Loa Loa (eye worm) RecQ helicase 0.0042 0.0147 0.0345
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0134 0.0134
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0009 0.002
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0128 0.03
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0128 0.0297
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0036 0.0114 0.2032
Schistosoma mansoni cpg binding protein 0.0031 0.0091 0.0211
Entamoeba histolytica hypothetical protein 0.0039 0.0128 0.2634
Brugia malayi Cytochrome P450 family protein 0.0068 0.028 0.0656
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0479 0.111
Echinococcus multilocularis leukotriene A 4 hydrolase 0.024 0.1181 0.1181
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0139 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0081 0.0191
Schistosoma mansoni hypothetical protein 0.0047 0.0172 0.0399
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0479 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Brugia malayi hypothetical protein 0.0039 0.0128 0.03
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.028 0.0656
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0479 0.1123
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0108 0.0252
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0036 0.0114 0.0268
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0036 0.0114 0.2701
Echinococcus granulosus expressed protein 0.075 0.3839 0.3839
Echinococcus multilocularis tumor protein p63 0.0364 0.1828 0.1828
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0479 0.3641
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0023 0.0049 0.0114
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0114 0.2032
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0147 0.0147
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0139 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0081 0.0191
Brugia malayi laminin-like protein K08C7.3 precursor 0.0023 0.0049 0.0114
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0081 0.0191
Echinococcus granulosus cpg binding protein 0.0031 0.0091 0.0091
Onchocerca volvulus 0.0015 0.0005 0.001
Schistosoma mansoni rab6-interacting 0.002 0.0034 0.0078
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0139 0.2863
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0077 0.1431
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.012 0.0553 0.1279
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0215 0.0499
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.0553 0.0553
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0034 0.0566
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0637 0.3252 0.7618
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0215 0.0505
Loa Loa (eye worm) abnormal epIthelia family member 0.0023 0.0049 0.0114
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0081 0.0191
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0128 0.0297
Brugia malayi CXXC zinc finger family protein 0.003 0.0082 0.0193
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0034 0.0034
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0077 0.0122
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.013 0.03
Echinococcus granulosus voltage dependent calcium channel subunit 0.0878 0.4509 0.4509
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0081 0.0191
Brugia malayi 6-phosphofructokinase 0.0106 0.0479 0.1123
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0479 1
Brugia malayi hypothetical protein 0.002 0.0034 0.0079
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Loa Loa (eye worm) leukotriene A4 hydrolase 0.024 0.1181 0.2768
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0114 0.2344
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0081 0.0189
Treponema pallidum 76K protein 0.0036 0.0114 0.0267
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0215 0.0215
Brugia malayi Protein kinase domain containing protein 0.0023 0.0047 0.011
Brugia malayi EGF-like domain containing protein 0.0023 0.0049 0.0114
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0006 0.0008
Echinococcus multilocularis expressed protein 0.0035 0.0108 0.0108
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.0058 0.1008
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0036 0.0114 0.2701
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0128 0.0297
Onchocerca volvulus 0.0082 0.0356 0.0732
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0244 0.1945
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0128 0.0297
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0049 0.0049
Echinococcus multilocularis lamin dm0 0.0082 0.0356 0.0356
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0128 0.0128
Echinococcus multilocularis slit 2 protein 0.0023 0.0049 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0129 0.0129
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0011
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0128 0.03
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0147 0.0345
Brugia malayi hypothetical protein 0.023 0.1128 0.2644
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0079
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0276 0.5708
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0276 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0081 0.0191
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0128 0.0297
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0081 0.0081
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.002
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0039 0.013 0.03
Loa Loa (eye worm) hypothetical protein 0.004 0.0134 0.0315
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0115 0.1123
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0081 0.0191
Schistosoma mansoni coup transcription factor 0.003 0.0081 0.0188
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0077 0.0584
Brugia malayi Cache domain containing protein 0.0389 0.1955 0.4581
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0047 0.011
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0081 0.0167
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0034 0.0136
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0139 0.0326
Echinococcus multilocularis lamin 0.0082 0.0356 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.011
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0081 0.1578
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0081 0.0081
Brugia malayi ecdysteroid receptor 0.003 0.0081 0.0191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0215 0.0215
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0479 0.0953
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0081 0.0189
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Schistosoma mansoni lamin 0.0082 0.0356 0.0825
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0128 0.0297
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0115 0.0115
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0128 0.0128
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0128 0.0297
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0389 0.1955 0.4581
Brugia malayi hypothetical protein 0.0027 0.0069 0.0162
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0095 0.1928
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0139 0.2819
Brugia malayi Doublecortin family protein 0.002 0.0034 0.0079
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0139 0.0251
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0034 0.0034
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0077 0.4859
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0023 0.0049 0.0112
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0162
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0128 0.03
Onchocerca volvulus 0.0015 0.0005 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0081 0.0081
Echinococcus granulosus RUN 0.002 0.0034 0.0034
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0081 0.0191
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0225 0.0225
Schistosoma mansoni cell polarity protein 0.0023 0.0049 0.0112
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0006 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.012 0.0553 0.0553
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0139 0.0328
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0553 0.1279
Echinococcus multilocularis geminin 0.0205 0.0995 0.0995
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0128 0.0297
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Mycobacterium ulcerans endonuclease IV 0.0078 0.0332 0.2587
Loa Loa (eye worm) hypothetical protein 0.0082 0.0356 0.0835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0215 0.0499
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0036 0.0114 0.0268
Schistosoma mansoni hypothetical protein 0.0023 0.0047 0.0109
Schistosoma mansoni nuclear hormone receptor 0.003 0.0081 0.0188
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0479 1
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0017 0.0017 0.0036
Mycobacterium ulcerans hypothetical protein 0.002 0.0034 0.0136
Brugia malayi hypothetical protein 0.0018 0.0019 0.0044
Schistosoma mansoni hypothetical protein 0.0036 0.0114 0.0265
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.4305 0.4305
Echinococcus granulosus expressed protein 0.0035 0.0108 0.0108
Loa Loa (eye worm) CUTiclin family member 0.0036 0.0114 0.0268
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0139 0.2482
Schistosoma mansoni polycystin 1-related 0.002 0.0034 0.0078
Brugia malayi phosphofructokinase 0.0106 0.0479 0.1123
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0115 0.0115
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0049 0.0049
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0128 0.0297
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0128 0.0297
Brugia malayi intermediate filament protein 0.0082 0.0356 0.0835
Entamoeba histolytica hypothetical protein 0.0039 0.013 0.2664
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0081 0.0188
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0081 0.0081
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0081 0.0081
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0081 0.0081
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0077 0.0584
Brugia malayi Zona pellucida-like domain containing protein 0.0036 0.0114 0.0268
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Brugia malayi laminin alpha chain 0.0023 0.0049 0.0114
Schistosoma mansoni survival motor neuron protein 0.0047 0.0172 0.0399
Schistosoma mansoni slit 0.0023 0.0049 0.0112
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Schistosoma mansoni cpg binding protein 0.003 0.0082 0.0191
Echinococcus multilocularis expressed protein 0.075 0.3839 0.3839
Brugia malayi Pre-SET motif family protein 0.012 0.0553 0.1295
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0036 0.0114 0.02
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0128 0.03
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0115 0.0202
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1235 0.2857
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1128 0.1128
Onchocerca volvulus 0.0036 0.0114 0.0235
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.012 0.0553 0.0553
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0128 0.0128
Trichomonas vaginalis set domain proteins, putative 0.0947 0.4867 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0251 0.1235 0.1235
Onchocerca volvulus 0.0036 0.0114 0.0235
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.002
Leishmania major hypothetical protein, conserved 0.0027 0.0069 0.0187
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0047 0.0047
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.004
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0034 0.0079
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0356 0.0835
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0479 0.1123
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0036 0.0114 0.2032
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0128 0.0128
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0103 0.2064
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0128 0.03
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0139 0.1001
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0147 0.0268
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0081 0.0191
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0115 0.0267
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1235 0.2857
Trichomonas vaginalis rotamase, putative 0.0035 0.0108 0.0186
Brugia malayi hypothetical protein 0.0017 0.0017 0.004
Schistosoma mansoni hypothetical protein 0.0036 0.0114 0.0265
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0128 0.03
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0423 0.2136 0.4942
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0128 0.0128
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0356 0.0835
Onchocerca volvulus 0.0015 0.0005 0.001
Onchocerca volvulus 0.002 0.0034 0.0069
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0215 0.0215
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0128 0.0128
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0077 0.1343
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.002
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0077 0.1431
Echinococcus granulosus collagen alpha 1VII chain 0.0036 0.0114 0.0114
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0157 0.0368
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0081 0.0191
Mycobacterium ulcerans epimerase 0.002 0.0034 0.0136
Schistosoma mansoni rotamase 0.0035 0.0108 0.0249
Schistosoma mansoni lipoxygenase 0.0057 0.0225 0.0522
Plasmodium falciparum thrombospondin-related anonymous protein 0.0036 0.0114 0.2701
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0795 0.4073 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0081 0.0081
Trichomonas vaginalis rotamase, putative 0.0034 0.0103 0.0178
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0128 0.0128
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0114 0.2344
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0081 0.0188
Onchocerca volvulus 0.0015 0.0005 0.001
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0047 0.0344
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Brugia malayi hypothetical protein 0.0111 0.0504 0.118
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0095 0.0621
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0038 0.0127 0.0296
Onchocerca volvulus 0.0053 0.0205 0.0422
Onchocerca volvulus 0.0015 0.0005 0.001
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0081 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0215 0.0499
Echinococcus multilocularis RUN 0.002 0.0034 0.0034
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1128 0.1128
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0036 0.0114 0.0892
Loa Loa (eye worm) hypothetical protein 0.012 0.0553 0.1295
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Onchocerca volvulus 0.0047 0.0172 0.0354
Brugia malayi steroid hormone receptor 0.003 0.0081 0.0191
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0189
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0128 0.03
Loa Loa (eye worm) CUTiclin-Like family member 0.0036 0.0114 0.0268
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1469 0.3399
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.0553 0.4456
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0081 0.0619
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0215 0.0505
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0479 0.3796
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0147 0.0268
Echinococcus multilocularis pikachurin 0.0023 0.0049 0.0049
Brugia malayi nuclear receptor NHR-88 0.003 0.0081 0.0191
Brugia malayi hypothetical protein 0.0039 0.0128 0.03
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0081 0.0081
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0128 0.0128
Onchocerca volvulus 0.003 0.0081 0.0167
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0139 0.2819
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0128 0.0128
Onchocerca volvulus 0.003 0.0082 0.0169
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0069 0.1183
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0081 0.0188
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0081 0.5218
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0108 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0114
Onchocerca volvulus 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0081 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0081 0.0191
Brugia malayi PXA domain containing protein 0.0039 0.0128 0.03
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0115 0.2361
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0069 0.1208
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0479 0.1165
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0036 0.0114 0.0268
Brugia malayi hypothetical protein 0.0016 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Schistosoma mansoni hypothetical protein 0.0205 0.0995 0.2302
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0036 0.0114 0.2032
Schistosoma mansoni DNA helicase recq5 0.0029 0.0081 0.0187
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0479 0.3796
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0276 0.5043
Echinococcus granulosus FTZ F1 alpha 0.003 0.0081 0.0081
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0251 0.1235 1
Echinococcus granulosus geminin 0.0205 0.0995 0.0995
Onchocerca volvulus 0.0036 0.0114 0.0235
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0069 0.0524
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0276 0.0647
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0332 1
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0128 0.0297
Echinococcus granulosus lamin dm0 0.0082 0.0356 0.0356
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0251 0.1235 0.1235
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0128 0.0128
Schistosoma mansoni lamin 0.0082 0.0356 0.0825
Brugia malayi nuclear hormone receptor 0.003 0.0081 0.0191
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0115 0.0115
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0081 0.0167
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0276 0.0276
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0139 0.0251
Brugia malayi Sulfatase family protein 0.0017 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Echinococcus granulosus bloom syndrome protein 0.0042 0.0147 0.0147
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0077 0.1549
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.1315 0.1315
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0081 0.0081
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0103 0.0836
Plasmodium vivax thrombospondin-related anonymous protein 0.0036 0.0114 0.2032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0081 0.0191
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0081 0.0081
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0081 0.0188
Schistosoma mansoni intermediate filament proteins 0.0082 0.0356 0.0825
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.013 0.013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0081 0.0081
Brugia malayi hypothetical protein 0.0036 0.0114 0.0268
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0128 0.03
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0115 0.8032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0081 0.0188
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1235 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0139 0.0139
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0139 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0168
Entamoeba histolytica hypothetical protein 0.0039 0.013 0.2664
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0115 0.0115
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0009 0.0009
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0139 0.3531
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0078 0.0332 0.6696
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0081 0.0191
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0006 0.0062
Brugia malayi von Willebrand Factor 0.0036 0.0114 0.0268
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0251 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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