Detailed information for compound 1420249

Basic information

Technical information
  • TDR Targets ID: 1420249
  • Name: MLS000858789
  • MW: 271.314 | Formula: C15H17N3O2
  • H donors: 2 H acceptors: 2 LogP: 2.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cn1)NC(=O)Nc1cc(C)cc(c1)C
  • InChi: 1S/C15H17N3O2/c1-10-6-11(2)8-13(7-10)18-15(19)17-12-4-5-14(20-3)16-9-12/h4-9H,1-3H3,(H2,17,18,19)
  • InChiKey: BNQVUQSZXQSEBE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3,5-dimethylphenyl)-N'-(6-methoxy-3-pyridinyl)urea
  • SMR000458868
  • SR-01000637219-1
  • ZINC00157948

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Caenorhabditis elegans Protein GLD-1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Protein Rev Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei variant surface glycoprotein (VSG), putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania donovani calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi tumor suppressor. Get druggable targets OG5_170288 All targets in OG5_170288
Trypanosoma congolense cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum calpain-like cysteine peptidase Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei hypothetical protein Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi calpain cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma congolense calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei gambiense calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) tumor suppressor Get druggable targets OG5_170288 All targets in OG5_170288
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei gambiense Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei gambiense calpain-like cysteine peptidase, putative,antigen, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Leishmania donovani hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Leishmania infantum hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.0133 0.1055 0.3263
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0083 0.0143
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0256
Leishmania major DNA topoisomerase III, putative 0.0021 0.0103 0.0673
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0083 0.0256
Brugia malayi nuclear hormone receptor 0.0019 0.0083 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.1501 1
Leishmania major hypothetical protein, conserved 0.0049 0.0342 0.2266
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0025 0.0134 0.0416
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0253
Loa Loa (eye worm) hypothetical protein 0.0044 0.03 0.0928
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0435 0.2886
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0083 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0093 0.0608
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0083 0.0143
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1075 0.7158
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.028 0.1857
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0091 0.0134
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0062 0.0452 0.3002
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0083 0.0143
Brugia malayi hypothetical protein 0.0033 0.0204 0.0632
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.028 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0091 0.0158
Brugia malayi Probable DNA topoisomerase II 0.0009 0.0002 0.0006
Schistosoma mansoni ap endonuclease 0.0042 0.028 0.0492
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0049 0.0083
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0328 0.2177
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0328 0.2177
Mycobacterium ulcerans esterase/lipase LipP 0.0185 0.1501 1
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.0149
Schistosoma mansoni jumonji/arid domain-containing protein 0.0024 0.013 0.0226
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0258 0.1709
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0093 0.0608
Plasmodium falciparum DNA topoisomerase 3, putative 0.004 0.0267 0.7812
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0083 0.0143
Loa Loa (eye worm) jmjC domain-containing protein 0.0024 0.013 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0083 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0034 0.0212
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0083 0.0256
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0258 0.1709
Brugia malayi PHD-finger family protein 0.0018 0.0082 0.0253
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.0149
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0049 0.0151
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0083 0.0143
Schistosoma mansoni hypothetical protein 0.0041 0.0275 0.0482
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0093 0.0608
Schistosoma mansoni inositol monophosphatase 0.0039 0.0258 0.0453
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0083 0.0143
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0328 0.2177
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.028 0.1857
Brugia malayi Smad1 0.0016 0.0061 0.019
Schistosoma mansoni hypothetical protein 0.0033 0.0204 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0083 0.0256
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0185 0.1501 0.15
Treponema pallidum DNA topoisomerase I (topA) 0.0081 0.0617 1
Echinococcus granulosus DNA topoisomerase 3 alpha 0.004 0.0267 0.0469
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0457 0.3033
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0437 0.1352
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0201 0.0352
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0049 0.007
Leishmania major hypothetical protein, conserved 0.0185 0.1501 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0185 0.1501 0.265
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0086 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0435 0.2886
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1171 0.2066
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0062 0.0191
Trypanosoma cruzi DNA topoisomerase III, putative 0.0021 0.0103 0.0673
Loa Loa (eye worm) hypothetical protein 0.0185 0.1501 0.4645
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0258 0.1709
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0009 0.0002 0.0006
Trypanosoma brucei calpain, putative 0.0135 0.1075 0.7158
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0034 0.0212
Brugia malayi jmjC domain containing protein 0.0024 0.013 0.0402
Schistosoma mansoni jumonji/arid domain-containing protein 0.0024 0.013 0.0226
Schistosoma mansoni rotamase 0.0025 0.0134 0.0234
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0258 0.1709
Loa Loa (eye worm) hypothetical protein 0.0019 0.0086 0.0267
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0083 0.0143
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0061 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0083 0.0256
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0632
Brugia malayi hypothetical protein 0.0049 0.0342 0.1057
Loa Loa (eye worm) hypothetical protein 0.0185 0.1501 0.4645
Toxoplasma gondii ABC1 family protein 0.0185 0.1501 1
Giardia lamblia DNA topoisomerase III 0.0021 0.0103 0.2334
Echinococcus multilocularis smad 0.0016 0.0061 0.0089
Onchocerca volvulus Serine\/threonine kinase homolog 0.006 0.0435 0.2886
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0034 0.0212
Onchocerca volvulus Alhambra homolog 0.0018 0.0082 0.0532
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0342 1
Echinococcus granulosus hypothetical protein 0.0033 0.0204 0.0357
Leishmania major DNA topoisomerase 1A 0.004 0.0267 0.177
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0148 0.1183 0.366
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0256
Schistosoma mansoni cpg binding protein 0.0032 0.0201 0.0352
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0034 0.0056
Schistosoma mansoni mucolipin 0.0048 0.0335 0.0588
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0258 0.1709
Loa Loa (eye worm) acetyltransferase 0.0146 0.1171 0.3623
Trypanosoma brucei polo-like protein kinase 0.006 0.0435 0.2886
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0066 0.0425
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0061 0.0396
Trichomonas vaginalis set domain proteins, putative 0.0151 0.121 0.8058
Mycobacterium ulcerans beta-lactamase 0.0185 0.1501 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0258 0.1709
Echinococcus multilocularis cpg binding protein 0.0032 0.0201 0.0298
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0061 0.0105
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.004 0.0267 0.0345
Echinococcus granulosus serine:threonine protein kinase PLK1 0.006 0.0435 0.0765
Brugia malayi hypothetical protein 0.0013 0.0034 0.0105
Schistosoma mansoni chromobox protein 0.0079 0.0594 0.1047
Schistosoma mansoni hypothetical protein 0.004 0.0263 0.0461
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0185 0.1501 0.4645
Brugia malayi Inositol-1 0.0039 0.0258 0.0799
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0008 0.0009
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0111 0.0193
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0185 0.1501 0.15
Brugia malayi steroid hormone receptor 0.0019 0.0083 0.0256
Schistosoma mansoni hypothetical protein 0.0022 0.0111 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0083 0.0256
Echinococcus granulosus mucolipin 3 0.0048 0.0335 0.0588
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.028 0.453
Loa Loa (eye worm) hypothetical protein 0.0035 0.0219 0.0677
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0083 0.0256
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0105
Echinococcus multilocularis PHD finger protein rhinoceros 0.0018 0.0082 0.012
Echinococcus granulosus lysine specific demethylase 5A 0.0024 0.013 0.0226
Entamoeba histolytica hypothetical protein 0.004 0.0263 0.603
Onchocerca volvulus 0.0019 0.0083 0.0538
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0083 0.0256
Plasmodium falciparum phd finger protein, putative 0.0018 0.0082 0.2346
Brugia malayi MH2 domain containing protein 0.0236 0.1936 0.5989
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.006 0.0435 0.0649
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0086 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0091 0.0158
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0083 0.0143
Entamoeba histolytica hypothetical protein 0.0013 0.0034 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.019 0.1255
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0342 0.2266
Schistosoma mansoni smad1 5 8 and 0.0016 0.0061 0.0105
Loa Loa (eye worm) TOPoisomerase family member 0.0009 0.0002 0.0006
Onchocerca volvulus 0.0151 0.121 0.8058
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1936 0.5989
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0083 0.0143
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0282
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0034 0.0937
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0342 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0105
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0061 0.0105
Plasmodium vivax SET domain protein, putative 0.002 0.0091 0.0595
Echinococcus multilocularis Smad4 0.0016 0.0061 0.0089
Echinococcus granulosus Smad4 0.0016 0.0061 0.0105
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0083 0.0143
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0061 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0083 0.0256
Trypanosoma cruzi DNA topoisomerase IA, putative 0.004 0.0267 0.177
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0135 0.1075 0.7158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0083 0.0256
Giardia lamblia DNA topoisomerase III 0.004 0.0267 0.6134
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0021 0.0103 0.0319
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0083 0.0143
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1075 0.7158
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1075 0.7158
Echinococcus granulosus GPCR family 2 0.0019 0.0086 0.0149
Trichomonas vaginalis hypothetical protein 0.0013 0.0034 0.0212
Brugia malayi nuclear receptor RXR 0.001 0.0008 0.0025
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0034 0.0212
Echinococcus granulosus smad 0.0016 0.0061 0.0105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0047 0.0079
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Schistosoma mansoni cpg binding protein 0.0031 0.0186 0.0325
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.1501 1
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.566 1
Trypanosoma cruzi DNA topoisomerase IA, putative 0.004 0.0267 0.177
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0185 0.1501 0.4645
Echinococcus granulosus cpg binding protein 0.0032 0.0201 0.0352
Trypanosoma brucei hypothetical protein, conserved 0.0185 0.1501 1
Mycobacterium tuberculosis Conserved protein 0.0185 0.1501 0.15
Onchocerca volvulus 0.0031 0.0186 0.1227
Entamoeba histolytica DNA topoisomerase III, putative 0.004 0.0267 0.6134
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0024 0.0129 0.085
Echinococcus granulosus Chromobox protein 3 0.0013 0.0034 0.0056
Echinococcus multilocularis peregrin 0.0022 0.0112 0.0165
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0437 0.1352
Chlamydia trachomatis DNA topoisomerase I 0.0081 0.0617 1
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0594 0.3951
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0083 0.0121
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.028 0.0868
Mycobacterium tuberculosis Probable esterase LipL 0.0185 0.1501 0.15
Onchocerca volvulus 0.0185 0.1501 1
Schistosoma mansoni mucolipin 0.0044 0.03 0.0527
Echinococcus granulosus survival motor neuron protein 1 0.017 0.1376 0.2428
Schistosoma mansoni chromobox protein 0.0013 0.0034 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0435 0.2886
Schistosoma mansoni hypothetical protein 0.0018 0.0082 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0034 0.0212
Loa Loa (eye worm) hypothetical protein 0.0041 0.0275 0.085
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.028 0.1857
Echinococcus multilocularis expressed protein 0.0025 0.0134 0.0198
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0034 0.0212
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 0.1183 0.366
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0034 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0134 0.0883
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0291 0.1926
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0083 0.0256
Schistosoma mansoni hypothetical protein 0.0438 0.3654 0.6455
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0025
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0021 0.0103 0.0178
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0012 0.0025 0.0154
Trypanosoma brucei calpain-like protein, putative 0.0135 0.1075 0.7158
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0008 0.001
Brugia malayi DNA topoisomerase III 0.004 0.0267 0.0828
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0083 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0083 0.0256
Brugia malayi nuclear receptor NHR-88 0.0019 0.0083 0.0256
Toxoplasma gondii PHD-finger domain-containing protein 0.0018 0.0082 0.0532
Toxoplasma gondii SWI2/SNF2-containing protein 0.0041 0.0273 0.1809
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0034 0.0212
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1075 0.7158
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.028 0.1857
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0025
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.0149
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0034 0.0105
Loa Loa (eye worm) hypothetical protein 0.0185 0.1501 0.4645
Brugia malayi MH2 domain containing protein 0.0016 0.0061 0.019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0083 0.0121
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0083 0.0121
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0091 0.0158
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.028 0.0492
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.028 0.1857
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0083 0.0143
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.026 0.5969
Echinococcus granulosus chromobox protein 2 0.0013 0.0034 0.0056
Brugia malayi SET domain containing protein 0.0014 0.0046 0.0141
Schistosoma mansoni smad1 5 8 and 0.0016 0.0061 0.0105
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0008 0.0025
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0291 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0034 0.0212
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0049 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.1501 0.265
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0291 0.1926
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0083 0.0256
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.028 0.0418
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0018 0.008 0.0137
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0258 0.1709
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0258 0.5924
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.002 0.0091 0.0134
Trypanosoma brucei DNA topoisomerase III, putative 0.004 0.0267 0.177
Trypanosoma brucei hypothetical protein 0.0135 0.1075 0.7158
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0258 0.417
Schistosoma mansoni smad 0.0016 0.0061 0.0105
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.006 0.0435 0.2886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.1183 0.2087
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0594 0.1839
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0177 0.1166
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.028 0.0868
Brugia malayi DNA topoisomerase III beta-1 0.0021 0.0103 0.0319
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0034 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0256
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0105
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0105
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0024 0.0129 0.2944
Giardia lamblia Kinase, PLK 0.006 0.0435 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0066 0.0425
Onchocerca volvulus 0.0032 0.0201 0.1327
Mycobacterium leprae Probable lipase LipE 0.0185 0.1501 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0093 0.0608
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1075 0.7158
Loa Loa (eye worm) histone methyltransferase 0.001 0.0011 0.0035
Trypanosoma brucei DNA topoisomerase IA, putative 0.004 0.0267 0.177
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0083 0.0256
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0435 0.2886
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0086 0.0127
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.028 0.1857
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0034 0.0212
Brugia malayi serine/threonine-protein kinase plk-2 0.006 0.0435 0.1345
Mycobacterium tuberculosis Conserved protein 0.0185 0.1501 0.15
Mycobacterium ulcerans DNA topoisomerase I 0.004 0.0267 0.177
Echinococcus multilocularis mucolipin 3 0.0048 0.0335 0.0499
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0263 0.0391
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.026 0.5969
Onchocerca volvulus 0.0013 0.0034 0.0212
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.006 0.0435 0.1345
Schistosoma mansoni survival motor neuron protein 0.0035 0.022 0.0386
Leishmania major DNA topoisomerase III, putative 0.0081 0.0617 0.4099
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0034 0.0212
Trypanosoma cruzi polo-like protein kinase, putative 0.006 0.0435 0.2886
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0204 0.0632
Loa Loa (eye worm) hypothetical protein 0.017 0.1376 0.4256
Loa Loa (eye worm) hypothetical protein 0.006 0.0437 0.1352
Loa Loa (eye worm) beta-lactamase 0.0185 0.1501 0.4645
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0061 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.03 0.1987
Trichomonas vaginalis Heterochromatin protein, putative 0.0013 0.0034 0.0212
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0083 0.0121
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0083 0.0143
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0034 0.0736
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0083 0.0256
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.03 0.1987
Schistosoma mansoni jumonji domain containing protein 0.0048 0.0334 0.0587
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0021 0.0103 0.0178
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0105
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1136 0.2004
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0018 0.0082 0.0141
Echinococcus granulosus dnaJ subfamily B 0.0438 0.3654 0.6455
Onchocerca volvulus 0.0035 0.022 0.1455
Loa Loa (eye worm) Smad1 0.0016 0.0061 0.019
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0034 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0083 0.0256
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0258 0.1709
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0083 0.0121
Loa Loa (eye worm) PHD-finger family protein 0.0018 0.0082 0.0253
Loa Loa (eye worm) helicase 0.0013 0.0034 0.0105
Trypanosoma cruzi polo-like protein kinase, putative 0.006 0.0435 0.2886
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.1501 1
Entamoeba histolytica hypothetical protein 0.0013 0.0034 0.0736
Brugia malayi hypothetical protein 0.001 0.0008 0.0025
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0258 0.0384
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0258 0.1709
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.028 0.453
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Loa Loa (eye worm) mucolipin 1 0.0048 0.0335 0.1035
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0024 0.0129 0.085
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.028 0.8195
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1075 0.7158
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0291 0.1926
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0081 0.0617 1
Schistosoma mansoni hypothetical protein 0.0033 0.0204 0.0357
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0105
Echinococcus granulosus chromobox protein 1 0.0079 0.0594 0.1047
Onchocerca volvulus 0.0021 0.0103 0.0673
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0437 0.1352
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0111 0.0164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.1183 0.2087
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0024 0.0129 0.085
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1075 0.7158
Brugia malayi beta-lactamase family protein 0.0185 0.1501 0.4645
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1936 0.5989
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.002 0.0091 0.0595
Schistosoma mansoni cpg binding protein 0.0032 0.0201 0.0352
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0083 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.1183 0.2087
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.044 0.0657
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0223 0.0221
Trichomonas vaginalis rotamase, putative 0.0024 0.0129 0.085
Loa Loa (eye worm) hypothetical protein 0.0049 0.0342 0.1057
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1075 0.7158
Giardia lamblia PHD finger protein 15 0.0018 0.0082 0.1842
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0291 0.1926
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1075 0.7158
Plasmodium vivax hypothetical protein, conserved 0.0185 0.1501 1
Brugia malayi jmjC domain containing protein 0.0061 0.044 0.1362
Toxoplasma gondii exonuclease III APE 0.0042 0.028 0.1857
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0083 0.0256
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0021 0.0103 0.0151
Brugia malayi CHD4 protein 0.0015 0.0049 0.0151
Toxoplasma gondii PHD-finger domain-containing protein 0.0018 0.0082 0.0532
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.1501 1
Brugia malayi ecdysteroid receptor 0.0019 0.0083 0.0256
Onchocerca volvulus 0.0035 0.0219 0.1445
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.1501 0.265
Toxoplasma gondii DNA topoisomerase family protein 0.004 0.0267 0.177
Mycobacterium tuberculosis DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-c 0.0019 0.0089 0.0087
Brugia malayi Coelomocyte uptake defective protein 5 0.0048 0.0335 0.1035
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.0149
Schistosoma mansoni smad1 5 8 and 0.0016 0.0061 0.0105
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0135 0.1075 0.7158
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0342 0.2266
Entamoeba histolytica hypothetical protein 0.004 0.0263 0.603
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0275 0.085
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0034 0.0937
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0093 0.0608
Mycobacterium tuberculosis Probable lipase LipD 0.0185 0.1501 0.15
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0034 0.0212
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.004 0.0267 0.177
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0034 0.0212
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0034 0.0212
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0342 0.2266
Echinococcus multilocularis chromobox protein 2 0.0013 0.0034 0.0048
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0086 0.0149
Brugia malayi Protein cec-1. 0.0013 0.0034 0.0105
Echinococcus multilocularis jumonji domain containing protein 0.0026 0.0143 0.0212
Schistosoma mansoni kinase 0.003 0.0184 0.0321
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.1183 0.1771
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0185 0.1501 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0291 0.1926
Mycobacterium ulcerans hypothetical protein 0.0185 0.1501 1
Schistosoma mansoni Smad4 0.0016 0.0061 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.1183 0.2087
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0177 0.1166
Brugia malayi beta-lactamase 0.0185 0.1501 0.4645
Echinococcus granulosus chromobox protein 1 0.0079 0.0594 0.1047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0133 0.1055 0.3263
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0024 0.0129 0.085
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0083 0.0121
Echinococcus multilocularis Chromo domain 0.0013 0.0034 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0083 0.0256
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.1501 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0034 0.0212
Echinococcus granulosus PHD finger protein rhinoceros 0.0018 0.0082 0.0141
Brugia malayi Bromodomain containing protein 0.0022 0.0112 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0083 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0256
Entamoeba histolytica hypothetical protein 0.004 0.0263 0.603
Echinococcus granulosus microtubule associated protein 2 0.0673 0.566 1
Brugia malayi MH2 domain containing protein 0.0016 0.0061 0.019
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0034 0.0937
Echinococcus multilocularis dnaJ subfamily B 0.0438 0.3654 0.5478
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0435 0.2886
Schistosoma mansoni coup transcription factor 0.0019 0.0083 0.0143
Trichomonas vaginalis esterase, putative 0.0185 0.1501 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0093 0.0608
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0486 0.0855
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0256
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0083 0.0143
Mycobacterium leprae conserved hypothetical protein 0.0185 0.1501 1
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0082 0.0532
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0034 0.0056
Entamoeba histolytica hypothetical protein 0.004 0.0263 0.603
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0034 0.0056
Onchocerca volvulus 0.0013 0.0034 0.0212
Loa Loa (eye worm) hypothetical protein 0.0185 0.1501 0.4645
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0083 0.0143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0091 0.0158
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.1501 1
Brugia malayi GRF zinc finger family protein 0.0009 0.0002 0.0006
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1075 0.7158
Schistosoma mansoni chromobox protein 0.0079 0.0594 0.1047
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1075 0.7158
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0435 0.2886
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0034 0.0105
Brugia malayi hypothetical protein 0.017 0.1376 0.4256
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0083 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0083 0.0256
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0083 0.0121
Trypanosoma cruzi DNA topoisomerase III, putative 0.004 0.0267 0.177
Echinococcus multilocularis rho GTPase activating protein 20 0.004 0.0267 0.0398
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0034 0.0212
Schistosoma mansoni hypothetical protein 0.0013 0.0034 0.0056
Echinococcus granulosus jumonji domain containing protein 0.0026 0.0143 0.025
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0034 0.0212
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0008 0.001
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0034 0.0212
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0011 0.0016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0011 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0083 0.0256
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0093 0.0608
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0186 0.0576
Brugia malayi hypothetical protein 0.0032 0.0194 0.06
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0256
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0083 0.0538
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0086 0.0267
Brugia malayi MH1 domain containing protein 0.0016 0.0061 0.019
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0034 0.0212
Loa Loa (eye worm) hypothetical protein 0.0185 0.1501 0.4645
Onchocerca volvulus 0.0185 0.1501 1
Schistosoma mansoni hypothetical protein 0.0035 0.022 0.0386
Brugia malayi Heterochromatin protein 1 0.0079 0.0594 0.1839
Mycobacterium tuberculosis Probable hydrolase 0.0185 0.1501 0.15
Echinococcus multilocularis protein quaking 0.0033 0.0204 0.0303
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0034 0.0056
Entamoeba histolytica DNA topoisomerase III, putative 0.0021 0.0103 0.2334
Trichomonas vaginalis rotamase, putative 0.0025 0.0134 0.0883
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0093 0.0608
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0083 0.0121
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.044 0.0774
Brugia malayi hypothetical protein 0.001 0.0008 0.0025
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0081 0.0617 0.1086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.1183 0.2087
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0083 0.0143
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0034 0.0736
Echinococcus multilocularis GPCR, family 2 0.0019 0.0086 0.0127
Brugia malayi beta-lactamase family protein 0.0185 0.1501 0.4645
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.566 0.8486
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0035 0.022 0.0681
Brugia malayi CXXC zinc finger family protein 0.0031 0.0186 0.0576
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0083 0.0143
Toxoplasma gondii peptidylprolyl isomerase 0.0024 0.0129 0.085
Schistosoma mansoni chromobox protein 0.0013 0.0034 0.0056
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.028 0.6434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0083 0.0256
Brugia malayi hypothetical protein 0.004 0.0263 0.0814
Loa Loa (eye worm) hypothetical protein 0.0185 0.1501 0.4645
Loa Loa (eye worm) DNA topoisomerase III 0.004 0.0267 0.0828
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0086 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.03 0.1987
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1171 0.3623
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1075 0.7158
Brugia malayi tumor suppressor. 0.0388 0.3232 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.1501 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1075 0.7158
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0061 0.0089
Brugia malayi Pre-SET motif family protein 0.002 0.0091 0.0282
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0594 0.3951
Mycobacterium tuberculosis Conserved protein 0.0185 0.1501 0.15
Entamoeba histolytica serine/threonine protein kinase, putative 0.006 0.0435 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0083 0.0121
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0258 0.0453
Trypanosoma cruzi DNA topoisomerase III, putative 0.004 0.0267 0.177
Echinococcus granulosus expressed protein 0.0025 0.0134 0.0234
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0185 0.1501 0.15
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0034 0.0105
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0025 0.0134 0.0416
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.028 0.6434
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0435 0.2886
Echinococcus multilocularis chromobox protein 1 0.0079 0.0594 0.0889
Schistosoma mansoni ap endonuclease 0.0042 0.028 0.0492
Entamoeba histolytica hypothetical protein 0.0013 0.0034 0.0736
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0256
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0061 0.019
Brugia malayi chromobox protein homolog 3 0.0044 0.03 0.0928
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.026 0.7603
Echinococcus multilocularis survival motor neuron protein 1 0.017 0.1376 0.206
Schistosoma mansoni inositol monophosphatase 0.0039 0.0258 0.0453
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0263 0.0461
Echinococcus granulosus peregrin 0.0022 0.0112 0.0195
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0342 0.2266
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.1183 0.1771
Mycobacterium tuberculosis Probable lipase LipE 0.0185 0.1501 0.15
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0034 0.0048
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.028 0.1857
Loa Loa (eye worm) hypothetical protein 0.0032 0.0194 0.0601
Loa Loa (eye worm) inositol-1 0.0039 0.0258 0.0799
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0263 0.0461
Brugia malayi MH1 domain containing protein 0.0016 0.0061 0.019
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0435 0.0765
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0034 0.0105
Mycobacterium ulcerans lipase LipD 0.0185 0.1501 1
Trypanosoma brucei DNA topoisomerase III, putative 0.0021 0.0103 0.0673
Echinococcus granulosus protein quaking 0.0033 0.0204 0.0357
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Loa Loa (eye worm) tumor suppressor 0.0388 0.3232 1
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.004 0.0267 0.177
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.001
Onchocerca volvulus 0.0185 0.1501 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0086 0.0267
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0034 0.0736
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1171 0.1753
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.028 0.1857
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0083 0.0143
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0083 0.0256
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0009 0.0002 0.0006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.6669 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0022 0.0115 0.0169
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0083 0.0538
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0342 0.2266
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0083 0.0538
Plasmodium vivax DNA topoisomerase 3, putative 0.004 0.0267 0.177
Echinococcus granulosus Chromo domain 0.0013 0.0034 0.0056
Echinococcus multilocularis beta LACTamase domain containing family member 0.0185 0.1501 0.2249
Echinococcus multilocularis chromobox protein 1 0.0079 0.0594 0.0889
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.019 0.1255
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.025 0.0772

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 27.376 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of Mex-5 Binding to TCR-2. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
EC50 (binding) = 186.273 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of POS-1 Binding to mex-3-RNA. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
IC50 (binding) = 7.148 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2280, AID2290, AID2459] ChEMBL. No reference
IC50 (binding) = 11.406 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2290 (Summary (gld-1 inhibitors)), 2280 (Primary screen (gld-1 inhibitors in singlicate))] ChEMBL. No reference
IC50 (functional) = 21.8 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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