Detailed information for compound 1426826

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 417.843 | Formula: C20H20ClN3O5
  • H donors: 1 H acceptors: 3 LogP: 3.11 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)Cl)OCc1onc(c1)C(=O)NCC(Oc1cccnc1)C
  • InChi: 1S/C20H20ClN3O5/c1-13(28-15-4-3-7-22-11-15)10-23-20(25)18-9-16(29-24-18)12-27-19-6-5-14(26-2)8-17(19)21/h3-9,11,13H,10,12H2,1-2H3,(H,23,25)
  • InChiKey: QTUIGICFLKDWDM-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0196 0.0342
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0026 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0029 0.047 0.0895
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0109 0.0228
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0066 0.1285 0.1263
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0102 0.0607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.2005 0.5408
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0102 0.0315
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0038 0.0035
Echinococcus multilocularis ferritin 0.001 0.0066 0.011
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0102 0.0154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0259 0.0658
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0109 0.0168
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0102 0.0297
Echinococcus multilocularis smad 0.0008 0.0026 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0109 0.0168
Echinococcus multilocularis protein dispatched 1 0.0058 0.112 0.299
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0109 0.0168
Echinococcus granulosus ornithine aminotransferase 0.0066 0.1285 0.3546
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.2005 0.5408
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0259 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0109 0.0168
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0109 0.0168
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0196 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0196 0.0478
Echinococcus granulosus expressed protein 0.001 0.0066 0.0113
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.047 0.047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0109 0.0168
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0026 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1163 0.2292
Schistosoma mansoni hypothetical protein 0.0019 0.0259 0.0639
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0109 0.0168
Mycobacterium tuberculosis Probable aminotransferase 0.0462 1 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0026 0.0002
Treponema pallidum DNA ligase (lig) 0.0012 0.0102 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0026 0.0026
Onchocerca volvulus 0.0029 0.047 0.0895
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0109 0.0228
Mycobacterium ulcerans L-lysine aminotransferase 0.0066 0.1285 0.1263
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0196 0.0464
Mycobacterium ulcerans hypothetical protein 0.0462 1 1
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0962 0.2635
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0462 1 1
Schistosoma mansoni dishevelled 0.0009 0.0038 0.0034
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0962 0.2558
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0102 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0154
Schistosoma mansoni ferritin light chain 0.001 0.0066 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.2005 0.5408
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0109 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0109 0.0168
Plasmodium vivax ornithine aminotransferase, putative 0.0066 0.1285 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0109 0.0228
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0038 0.0025
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0196 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.047 0.0445
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0109 0.0228
Schistosoma mansoni patched 1 0.0051 0.0962 0.2558
Schistosoma mansoni apoferritin-2 0.001 0.0066 0.011
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0102 0.0607
Loa Loa (eye worm) hypothetical protein 0.0012 0.0109 0.0168
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.047 0.0445
Echinococcus granulosus nibrin 0.0012 0.0102 0.0215
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0109 0.0228
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.3845 0.7694
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0311 0.1765
Schistosoma mansoni smad1 5 8 and 0.0008 0.0026 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0196 0.0464
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0021 0.0311 0.0575
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0196 0.1349
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0285 0.0285
Brugia malayi isocitrate dehydrogenase 0.0016 0.0196 0.0342
Brugia malayi steroid hormone receptor 0.0012 0.0109 0.0168
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0109 0.0168
Echinococcus granulosus ferritin 0.001 0.0066 0.0113
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0109 0.0228
Schistosoma mansoni dep domain containing protein 0.0009 0.0038 0.0034
Loa Loa (eye worm) hypothetical protein 0.0012 0.0109 0.0168
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0109 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0102 0.0077
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0066 0.1285 1
Echinococcus multilocularis protein patched 0.0051 0.0962 0.2558
Echinococcus multilocularis nibrin 0.0012 0.0102 0.0209
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0196 0.0464
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0109 0.0228
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0285 0.0285
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0038 0.0034
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0109 0.0228
Schistosoma mansoni topbp1 0.0012 0.0102 0.0209
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0259 0.0471
Brugia malayi DKFZp564C0469 protein 0.0012 0.0102 0.0154
Brugia malayi hypothetical protein 0.0012 0.0102 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0102 0.4501
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.047 0.0445
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0066 0.1285 0.1285
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.047 0.0445
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0066 0.1285 0.1263
Brugia malayi hypothetical protein 0.0012 0.0102 0.0154
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0196 0.0464
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0109 0.0228
Loa Loa (eye worm) hypothetical protein 0.0119 0.2453 0.4889
Echinococcus multilocularis expressed protein 0.001 0.0066 0.011
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.3573 0.9693
Loa Loa (eye worm) hypothetical protein 0.0062 0.1214 0.2394
Loa Loa (eye worm) hypothetical protein 0.0021 0.0311 0.0575
Loa Loa (eye worm) hypothetical protein 0.0021 0.0311 0.0575
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0026 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0109 0.0168
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0026 0.0002
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0102 0.0077
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0066 0.1285 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0196 0.0464
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0038 0.0034
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0311 0.2265
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0026 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0285 0.0285
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0109 0.0168
Echinococcus granulosus Smad4 0.0008 0.0026 0.0002
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0026 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0102 0.0077
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0109 0.0228
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0285 0.0285
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0066 0.1285 0.1263
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0066 0.1285 0.1263
Schistosoma mansoni ferritin 0.001 0.0066 0.011
Echinococcus multilocularis Smad4 0.0008 0.0026 0.0002
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0038 0.0025
Echinococcus granulosus Aminotransferase class III 0.0066 0.1285 0.3546
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0972 0.751
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0109 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0109 0.0168
Brugia malayi hypothetical protein 0.0009 0.0038 0.0025
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0102 0.0607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.2005 0.5572
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0102 0.0607
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.3573 0.9987
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0038 0.0034
Loa Loa (eye worm) hypothetical protein 0.0051 0.0962 0.1886
Trichomonas vaginalis ferritin, putative 0.001 0.0066 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0109 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0109 0.0168
Loa Loa (eye worm) hypothetical protein 0.0021 0.0311 0.0575
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0877 0.351
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.047 0.183
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0259 0.0639
Loa Loa (eye worm) hypothetical protein 0.0041 0.0745 0.1449
Brugia malayi hypothetical protein 0.0009 0.0038 0.0025
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.047 0.0445
Schistosoma mansoni topbp1 0.0012 0.0102 0.0209
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0109 0.0168
Schistosoma mansoni ferritin light chain 0.001 0.0066 0.011
Schistosoma mansoni hypothetical protein 0.0019 0.0259 0.0639
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0259 0.0471
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0109 0.0235
Schistosoma mansoni apoferritin-2 0.001 0.0066 0.011
Onchocerca volvulus 0.0012 0.0109 0.0168
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0066 0.1285 0.2537
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.047 0.047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0154
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0471
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0109 0.0168
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0311 0.0286
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0962 0.1886
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0196 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0038 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.2005 0.3987
Schistosoma mansoni ferritin 0.001 0.0066 0.011
Echinococcus multilocularis ornithine aminotransferase 0.0066 0.1285 0.3441
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0109 0.0228
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0038 0.0034
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0109 0.0228
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0025
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0026 0.0002
Echinococcus granulosus smad 0.0008 0.0026 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0025
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0066 0.004
Onchocerca volvulus 0.0009 0.0038 0.0025
Mycobacterium ulcerans acetylornithine aminotransferase 0.0066 0.1285 0.1263
Brugia malayi MH2 domain containing protein 0.0008 0.0026 0.0002
Schistosoma mansoni DNA ligase IV 0.0012 0.0102 0.0209
Loa Loa (eye worm) hypothetical protein 0.0012 0.0109 0.0168
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0109 0.0235
Brugia malayi nuclear receptor NHR-88 0.0012 0.0109 0.0168
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0196 0.0342
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0026 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.2005 0.5408
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0462 1 1
Schistosoma mansoni hypothetical protein 0.0049 0.0921 0.2447
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0196 0.1349
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.2493 0.6741
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0109 0.0235
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0972 0.751
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.3686 0.7373
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.2005 0.5572
Echinococcus multilocularis ornithine aminotransferase 0.0066 0.1285 0.3441
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0038 0.0034
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0026 0.0026
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0877 0.6762
Schistosoma mansoni hypothetical protein 0.0049 0.0921 0.2447
Brugia malayi MH2 domain containing protein 0.0008 0.0026 0.0002
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0462 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0972 0.751
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0962 0.0939
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0102 0.0077
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0038 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0109 0.0168
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0196 0.0196
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0102 0.0209
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.047 1
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0038 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0109 0.0168
Loa Loa (eye worm) hypothetical protein 0.0021 0.0311 0.0575
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.3686 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.047 1
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0877 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0109 0.0228
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0196 0.1349
Mycobacterium ulcerans hypothetical protein 0.0029 0.047 0.0445
Loa Loa (eye worm) hypothetical protein 0.006 0.1163 0.2292
Brugia malayi Pax transcription factor protein 2 0.0234 0.499 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0109 0.0228
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0038 0.0034
Schistosoma mansoni hypothetical protein 0.0019 0.0259 0.0639
Brugia malayi MH1 domain containing protein 0.0008 0.0026 0.0002
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0972 0.0948
Schistosoma mansoni Smad4 0.0008 0.0026 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0109 0.0168
Echinococcus multilocularis Aminotransferase class III 0.0066 0.1285 0.3441
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.047 0.183
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0066 0.1285 0.1263
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0154
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0196 0.0464
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0066 0.1285 0.1285
Onchocerca volvulus 0.0234 0.499 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0154
Schistosoma mansoni hypothetical protein 0.0019 0.0259 0.0639
Brugia malayi topoisomerase 0.0012 0.0102 0.0154
Entamoeba histolytica hypothetical protein 0.0012 0.0102 0.0315
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0102 0.0209
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0066 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0109 0.0168
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.2005 0.3987
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0066 0.1285 0.1263
Onchocerca volvulus 0.0012 0.0102 0.0154
Schistosoma mansoni hypothetical protein 0.0049 0.0921 0.2447
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.2453 0.4889
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0109 0.0228
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0102 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0029 0.047 0.0895
Schistosoma mansoni smad 0.0008 0.0026 0.0002
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0066 0.1285 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0026 0.0026
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0066 0.1285 0.1285
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0026 0.0026
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0026 0.0026
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0109 0.0228
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0962 0.2635
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0109 0.0168
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0109 0.0168
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0196 1
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0102 0.0077
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.2453 0.6832
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.047 0.183
Brugia malayi N-terminal motif family protein 0.0182 0.3845 0.7694
Echinococcus granulosus expressed conserved protein 0.0112 0.2294 0.6386
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0102 0.0215
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0038 0.0035
Brugia malayi MH2 domain containing protein 0.0124 0.2563 0.5112
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0102 0.0077
Loa Loa (eye worm) hypothetical protein 0.0029 0.047 0.0895
Loa Loa (eye worm) hypothetical protein 0.0012 0.0109 0.0168
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0109 0.0235
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.2563 0.5112
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0154
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0066 0.1285 0.3441
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1163 0.2292
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.047 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0311 0.2265
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0026 0.0026
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0102 0.4501
Loa Loa (eye worm) pax transcription factor protein 2 0.0234 0.499 1
Brugia malayi ecdysteroid receptor 0.0012 0.0109 0.0168
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0066 0.1285 0.1285
Loa Loa (eye worm) acetyltransferase 0.0175 0.3686 0.7373
Echinococcus granulosus GPCR family 2 0.0019 0.0259 0.0658
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0102 0.4501
Schistosoma mansoni hypothetical protein 0.0049 0.0921 0.2447
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0972 0.0948
Loa Loa (eye worm) hypothetical protein 0.0182 0.3845 0.7694
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0109 0.0235
Loa Loa (eye worm) Smad1 0.0008 0.0026 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0109 0.0168
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0102 0.0077
Schistosoma mansoni dishevelled 0.0009 0.0038 0.0034
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0109 0.0228
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1163 0.2292
Brugia malayi Smad1 0.0008 0.0026 0.0002
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0196 0.1349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0109 0.0168
Plasmodium falciparum ornithine aminotransferase 0.0066 0.1285 1
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0109 0.0168
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0196 0.3826
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0109 0.0228
Toxoplasma gondii hypothetical protein 0.0009 0.0038 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.2005 0.5408
Brugia malayi nuclear hormone receptor 0.0012 0.0109 0.0168
Schistosoma mansoni coup transcription factor 0.0012 0.0109 0.0228
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0026 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0109 0.0235
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0038 0.0025
Brugia malayi MH1 domain containing protein 0.0008 0.0026 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0109 0.0168
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0109 0.0228
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0972 0.2663
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.2453 0.6631
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0154
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0038 0.0025
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0109 0.0235
Echinococcus multilocularis GPCR, family 2 0.0019 0.0259 0.0639
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0259 0.0658
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0109 0.0235
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0038 0.0025
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.2563 0.5112
Schistosoma mansoni smad1 5 8 and 0.0008 0.0026 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0109 0.0168
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0066 0.1285 0.1263
Brugia malayi AMP-binding enzyme family protein 0.0029 0.047 0.0895
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.3578 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0109 0.0168
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0102 0.0077
Schistosoma mansoni ferritin 0.001 0.0066 0.011
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0102 0.0077
Echinococcus multilocularis expressed conserved protein 0.0112 0.2294 0.6198
Schistosoma mansoni ferritin 0.001 0.0066 0.011
Brugia malayi DIX domain containing protein 0.0009 0.0038 0.0025
Brugia malayi CHE-14 protein 0.0051 0.0962 0.1886
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.047 0.0445
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.2453 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.3686 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.047 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0109 0.0168
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0102 0.4501
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0102 0.0077
Schistosoma mansoni smad1 5 8 and 0.0008 0.0026 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0109 0.0168
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.047 0.0445
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0066 0.0066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0259 0.0471
Loa Loa (eye worm) hypothetical protein 0.0029 0.047 0.0895
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.047 0.0445
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0745 0.1449
Brugia malayi AMP-binding enzyme family protein 0.0029 0.047 0.0895
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0102 0.0154
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0026 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0025
Schistosoma mansoni hypothetical protein 0.0041 0.0745 0.1965
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0038 0.0034
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0066 0.004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0109 0.0168
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0102 0.4501

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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