Detailed information for compound 1427234

Basic information

Technical information
  • TDR Targets ID: 1427234
  • Name: 2-[[4-[(2-chlorophenyl)methylamino]-1-methylp yrazolo[5,4-d]pyrimidin-6-yl]amino]ethanol
  • MW: 332.788 | Formula: C15H17ClN6O
  • H donors: 3 H acceptors: 4 LogP: 2.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCNc1nc(NCc2ccccc2Cl)c2c(n1)n(C)nc2
  • InChi: 1S/C15H17ClN6O/c1-22-14-11(9-19-22)13(20-15(21-14)17-6-7-23)18-8-10-4-2-3-5-12(10)16/h2-5,9,23H,6-8H2,1H3,(H2,17,18,20,21)
  • InChiKey: QFNKFTDYZZRFTR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-[(2-chlorophenyl)methylamino]-1-methyl-pyrazolo[5,4-d]pyrimidin-6-yl]amino]ethanol
  • 2-[[4-[(2-chlorophenyl)methylamino]-1-methyl-6-pyrazolo[5,4-d]pyrimidinyl]amino]ethanol
  • 2-[[4-[(2-chlorobenzyl)amino]-1-methyl-pyrazolo[5,4-d]pyrimidin-6-yl]amino]ethanol
  • G414-0577
  • NCGC00131204-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0237 0.0513
Echinococcus multilocularis muscleblind protein 0.0152 0.4122 0.4122
Echinococcus granulosus RUN 0.002 0.0065 0.0065
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0237 0.059
Brugia malayi Doublecortin family protein 0.002 0.0065 0.0076
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0065 0.0065
Trichomonas vaginalis beta lactamase domain, putative 0.0034 0.0484 0.0569
Plasmodium falciparum glutathione reductase 0.0038 0.062 0.1474
Brugia malayi Cytochrome P450 family protein 0.0046 0.0852 0.1002
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0237 0.059
Brugia malayi hypothetical protein 0.002 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.0034 0.0484 0.057
Entamoeba histolytica alkyl sulfatase, putative 0.0034 0.0484 0.1206
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.2438 0.6087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.543 0.543
Loa Loa (eye worm) hypothetical protein 0.0106 0.271 0.3192
Plasmodium vivax RNA helicase-1, putative 0.0148 0.4005 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.543 1
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.062 0.1546
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.1412 0.1412
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0034 0.0484 0.1206
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0148 0.4005 0.4005
Schistosoma mansoni loxhd1 0.002 0.0065 0.0119
Entamoeba histolytica metallo-beta-lactamase family protein 0.0034 0.0484 0.1206
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0002 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.543 0.543
Onchocerca volvulus 0.0115 0.2987 0.5502
Onchocerca volvulus 0.0033 0.0449 0.0723
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0065 0.0077
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0212 0.0212
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.2137 0.5334
Leishmania major eukaryotic initiation factor 4a, putative 0.0148 0.4005 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0484 0.0569
Loa Loa (eye worm) hypothetical protein 0.0046 0.0848 0.0998
Echinococcus multilocularis geminin 0.0168 0.4621 0.4621
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0065 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.849 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0001 0.0001
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0237 0.0588
Plasmodium falciparum cytosolic glyoxalase II 0.0034 0.0484 0.1131
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.849 1
Onchocerca volvulus 0.0034 0.0484 0.0788
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0022 0.0119 0.0218
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0071 0.1618 0.6275
Loa Loa (eye worm) MH2 domain-containing protein 0.0262 0.7521 0.8858
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.1742 0.2052
Loa Loa (eye worm) hypothetical protein 0.0115 0.2987 0.3518
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1235 0.304
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0729 0.0858
Mycobacterium ulcerans hypothetical protein 0.0034 0.0484 0.1138
Trichomonas vaginalis beta lactamase domain, putative 0.0034 0.0484 0.0569
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0212 0.0249
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0076
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0147 0.3984 1
Mycobacterium tuberculosis Possible hydrolase 0.0034 0.0484 0.1204
Loa Loa (eye worm) hypothetical protein 0.0034 0.0484 0.057
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.1235 0.3082
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0034 0.0484 0.0788
Schistosoma mansoni zinc phosphodiesterase 0.0034 0.0484 0.0891
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1235 0.1235
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.5376 0.6332
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0237 0.0513
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0034 0.0484 0.0891
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0148 0.4005 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0148 0.4005 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.004
Echinococcus granulosus eukaryotic initiation factor 4A 0.0148 0.4005 0.4005
Trichomonas vaginalis A-type flavoprotein 0.0034 0.0484 0.0569
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0982 0.1808
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0148 0.4005 0.7377
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.1412 0.1412
Loa Loa (eye worm) hypothetical protein 0.005 0.0982 0.1156
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.5376 0.6332
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0034 0.0484 0.0484
Trichomonas vaginalis beta lactamase domain, putative 0.0034 0.0484 0.0569
Loa Loa (eye worm) TAR-binding protein 0.0138 0.3683 0.4338
Trichomonas vaginalis beta lactamase domain, putative 0.0034 0.0484 0.0569
Mycobacterium leprae POSSIBLE HYDROLASE 0.0034 0.0484 0.112
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.5376 0.6332
Echinococcus granulosus ETHE1 protein 0.0034 0.0484 0.0484
Trypanosoma cruzi glyoxalase II 0.0034 0.0484 0.1206
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.5696 0.6709
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0827 0.0973
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0138 0.3683 0.4338
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0034 0.0484 0.0484
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0212 0.0527
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0034 0.0484 0.1206
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0034 0.0484 0.1206
Brugia malayi metallo-beta-lactamase superfamily protein 0.0034 0.0484 0.0569
Brugia malayi chromobox protein homolog 3 0.0042 0.0729 0.0857
Trichomonas vaginalis cdc25b, putative 0.0115 0.2987 0.3518
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0625 0.0625
Brugia malayi RNA binding protein 0.0138 0.3683 0.4337
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0065 0.0065
Mycobacterium leprae conserved hypothetical protein 0.0034 0.0484 0.112
Onchocerca volvulus 0.0026 0.0237 0.0324
Schistosoma mansoni chromobox protein 0.0075 0.1742 0.3209
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0237 0.0513
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.2137 0.5334
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0484 0.0569
Mycobacterium ulcerans hypothetical protein 0.0034 0.0484 0.1138
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.004
Mycobacterium ulcerans hydrolase 0.0034 0.0484 0.1138
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0351 0.0413
Toxoplasma gondii thioredoxin reductase 0.0038 0.062 0.1546
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0237 0.059
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0827 0.1434
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.062 0.1544
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.062 0.073
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1235 0.304
Schistosoma mansoni lipoxygenase 0.0122 0.3201 0.5896
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0034 0.0484 0.1206
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0148 0.4005 0.4717
Mycobacterium ulcerans hypothetical protein 0.0026 0.0237 0.0513
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0237 0.0513
Schistosoma mansoni zinc phosphodiesterase 0.0034 0.0484 0.0891
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.2137 0.5334
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0237 0.0513
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.004
Chlamydia trachomatis ribonuclease Z 0.0034 0.0484 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.2137 0.8631
Loa Loa (eye worm) hypothetical protein 0.0033 0.0449 0.0529
Mycobacterium ulcerans hydrolase 0.0034 0.0484 0.1138
Schistosoma mansoni hypothetical protein 0.0034 0.0484 0.0891
Loa Loa (eye worm) hypothetical protein 0.0152 0.4122 0.4854
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.3201 0.3201
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.3201 0.3201
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0237 0.059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.543 0.6395
Brugia malayi Heterochromatin protein 1 0.0075 0.1742 0.2052
Echinococcus multilocularis tar DNA binding protein 0.0138 0.3683 0.3683
Onchocerca volvulus Putative hydrolase PNKD 0.0034 0.0484 0.0788
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.2137 0.5334
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0237 0.0513
Schistosoma mansoni tar DNA-binding protein 0.0138 0.3683 0.6783
Loa Loa (eye worm) hypothetical protein 0.0115 0.2987 0.3518
Schistosoma mansoni hypothetical protein 0.0168 0.4621 0.851
Schistosoma mansoni tar DNA-binding protein 0.0138 0.3683 0.6783
Schistosoma mansoni tar DNA-binding protein 0.0138 0.3683 0.6783
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0065 0.0065
Entamoeba histolytica alkyl sulfatase, putative 0.0034 0.0484 0.1206
Echinococcus granulosus chromobox protein 1 0.0075 0.1742 0.1742
Brugia malayi MH2 domain containing protein 0.0262 0.7521 0.8858
Schistosoma mansoni hypothetical protein 0.0168 0.4621 0.851
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0148 0.4005 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0065 0.0076
Mycobacterium leprae Beta-lactamase-like protein 0.0034 0.0484 0.112
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0635 0.0635
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0625 0.0625
Mycobacterium leprae conserved hypothetical protein 0.0034 0.0484 0.112
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0852 0.1003
Onchocerca volvulus Glucosylceramidase homolog 0.0193 0.5376 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.004
Brugia malayi hypothetical protein 0.0034 0.0484 0.0569
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0115 0.2987 0.3518
Loa Loa (eye worm) hypothetical protein 0.0026 0.0237 0.0279
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0827 0.0973
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0103 0.0256
Trichomonas vaginalis chromobox protein, putative 0.0075 0.1742 0.2052
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.1235 0.3081
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0148 0.4005 1
Brugia malayi Rhodanese-like domain containing protein 0.0115 0.2987 0.3518
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0148 0.4005 1
Brugia malayi Bromodomain containing protein 0.0041 0.0704 0.0828
Schistosoma mansoni polycystin 1-related 0.002 0.0065 0.0119
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0237 0.0278
Brugia malayi follicle stimulating hormone receptor 0.0252 0.7201 0.8481
Loa Loa (eye worm) hypothetical protein 0.0026 0.0237 0.0279
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1235 0.1235
Brugia malayi ethe1-prov protein 0.0034 0.0484 0.0569
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0212 0.039
Leishmania major hypothetical protein, conserved 0.0034 0.0484 0.1206
Trypanosoma cruzi glyoxalase II 0.0034 0.0484 0.1206
Echinococcus granulosus zinc finger protein 0.0021 0.0084 0.0084
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.062 0.1474
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.2137 0.5334
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0034 0.0484 0.1206
Trichomonas vaginalis beta lactamase domain, putative 0.0034 0.0484 0.0569
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0294 0.849 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0122
Loa Loa (eye worm) RNA binding protein 0.0138 0.3683 0.4338
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.5376 0.6332
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0001 0.0001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0729 0.1249
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0729 0.0857
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0034 0.0484 0.1206
Loa Loa (eye worm) hypothetical protein 0.0026 0.0237 0.0279
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.5376 0.6332
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0071 0.1618 0.4039
Brugia malayi PHD-finger family protein 0.0027 0.026 0.0306
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0115 0.2987 0.3518
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0119 0.014
Mycobacterium tuberculosis Beta lactamase like protein 0.0034 0.0484 0.1204
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0294 0.849 1
Echinococcus multilocularis muscleblind protein 1 0.0152 0.4122 0.4122
Entamoeba histolytica type A flavoprotein, putative 0.0034 0.0484 0.1206
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0034 0.0484 0.1131
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0237 0.0278
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0034 0.0484 0.057
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0034 0.0484 0.1206
Plasmodium vivax unspecified product 0.0034 0.0484 0.1131
Brugia malayi Rhodanese-like domain containing protein 0.0115 0.2987 0.3518
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0034 0.0484 0.0484
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0034 0.0484 0.057
Schistosoma mansoni chromobox protein 0.0075 0.1742 0.3209
Mycobacterium tuberculosis Conserved protein 0.0034 0.0484 0.1204
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0065 0.0077
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0034 0.0484 0.1206
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0484 0.0569
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0001 0.0001
Mycobacterium ulcerans lipoprotein LpqF 0.0071 0.1618 0.4011
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.1235 0.2275
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0001 0.0001
Mycobacterium ulcerans beta lactamase-like protein 0.0034 0.0484 0.1138
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0237 0.0513
Mycobacterium tuberculosis Conserved protein 0.0034 0.0484 0.1204
Schistosoma mansoni hypothetical protein 0.0034 0.0484 0.0891
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.2438 0.6087
Schistosoma mansoni hypothetical protein 0.0034 0.0484 0.0891
Trichomonas vaginalis chromobox protein, putative 0.0075 0.1742 0.2052
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0034 0.0484 0.1206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.543 0.543
Onchocerca volvulus 0.0115 0.2987 0.5502
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0148 0.4005 0.4717
Echinococcus multilocularis ETHE1 protein 0.0034 0.0484 0.0484
Echinococcus multilocularis tumor protein p63 0.0342 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0784 0.0924
Mycobacterium tuberculosis Conserved protein 0.0034 0.0484 0.1204
Treponema pallidum ATP-dependent RNA helicase 0.0148 0.4005 1
Echinococcus multilocularis chromobox protein 1 0.0075 0.1742 0.1742
Mycobacterium ulcerans glyoxalase II, GloB 0.0034 0.0484 0.1138
Loa Loa (eye worm) hypothetical protein 0.0076 0.1777 0.2093
Brugia malayi glutathione reductase 0.0038 0.062 0.0729
Schistosoma mansoni tar DNA-binding protein 0.0138 0.3683 0.6783
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0002 0.0003
Trypanosoma brucei beta lactamase 0.0071 0.1618 0.404
Brugia malayi Muscleblind-like protein 0.0152 0.4122 0.4854
Onchocerca volvulus 0.0115 0.2987 0.5502
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.543 0.6395
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0182 0.0182
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0034 0.0484 0.1206
Brugia malayi Bromodomain containing protein 0.0081 0.1919 0.2259
Plasmodium falciparum thioredoxin reductase 0.0038 0.062 0.1474
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0212 0.0212
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0593 0.0697
Entamoeba histolytica type A flavoprotein, putative 0.0034 0.0484 0.1206
Leishmania major metallo-beta-lactamase family protein-like protein 0.0034 0.0484 0.1206
Mycobacterium ulcerans hypothetical protein 0.0034 0.0484 0.1138
Echinococcus granulosus muscleblind protein 0.0152 0.4122 0.4122
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0484 0.0569
Schistosoma mansoni tar DNA-binding protein 0.0138 0.3683 0.6783
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0635 0.0635
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0115 0.2987 0.2987
Brugia malayi Thioredoxin reductase 0.0038 0.062 0.0729
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0034 0.0484 0.057
Trichomonas vaginalis cdc25c, putative 0.0115 0.2987 0.3518
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.849 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.543 1
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0115 0.2987 0.2987
Onchocerca volvulus 0.005 0.0982 0.1726
Onchocerca volvulus 0.0115 0.2987 0.5502
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0237 0.0588
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0034 0.0484 0.1206
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0034 0.0484 0.1138
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0034 0.0484 0.0484
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0182 0.0335
Trypanosoma brucei glyoxalase II 0.0034 0.0484 0.1206
Trypanosoma cruzi glyoxalase II 0.0034 0.0484 0.1206
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0034 0.0484 0.1206
Schistosoma mansoni rab6-interacting 0.002 0.0065 0.0119
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0148 0.4005 0.4717
Trypanosoma brucei trypanothione reductase 0.0038 0.062 0.1546
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.543 0.543
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.1235 0.1454
Loa Loa (eye worm) hypothetical protein 0.0152 0.4122 0.4854
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0147 0.3984 0.9946
Brugia malayi RNA recognition motif domain containing protein 0.0138 0.3683 0.4337
Leishmania major metallo-beta-lactamase family-like protein 0.0034 0.0484 0.1206
Plasmodium vivax glutathione reductase, putative 0.0038 0.062 0.1474
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.2438 1
Mycobacterium ulcerans hydrolase 0.0034 0.0484 0.1138
Echinococcus multilocularis zinc phosphodiesterase 0.0034 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0041 0.0706 0.0831
Leishmania major trypanothione reductase 0.0038 0.062 0.1546
Echinococcus multilocularis RUN 0.002 0.0065 0.0065
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0034 0.0082
Echinococcus multilocularis zinc finger protein 0.0021 0.0084 0.0084
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0148 0.4005 0.7377
Trichomonas vaginalis beta lactamase domain, putative 0.0034 0.0484 0.0569
Entamoeba histolytica hypothetical protein 0.0025 0.0212 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0729 0.0857
Trichomonas vaginalis cdc25b, putative 0.0115 0.2987 0.3518
Schistosoma mansoni lipoxygenase 0.0085 0.2068 0.3809
Echinococcus multilocularis chromobox protein 1 0.0075 0.1742 0.1742
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0148 0.4005 0.4005
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0484 0.0569
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0115 0.2987 0.3518
Schistosoma mansoni bromodomain containing protein 0.0068 0.1531 0.2819
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0237 0.059
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.5696 0.6709
Plasmodium falciparum eukaryotic initiation factor 4A 0.0148 0.4005 1
Brugia malayi eukaryotic initiation factor 4A 0.0148 0.4005 0.4717
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0034 0.0484 0.1206
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.004
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0034 0.0484 0.1206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.543 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.271 0.3192
Mycobacterium tuberculosis Probable reductase 0.0088 0.2137 0.5334
Mycobacterium ulcerans hypothetical protein 0.0034 0.0484 0.1138
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.7201 0.8481
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0484 0.1204
Trichomonas vaginalis apoptosis inducing factor, putative 0.0038 0.0593 0.0697
Schistosoma mansoni rab6-interacting 0.002 0.0065 0.0119
Loa Loa (eye worm) glutathione reductase 0.0038 0.062 0.073
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0034 0.0484 0.1206
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0351 0.0413
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0115 0.2987 0.5502
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0034 0.0484 0.1206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0212 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.849 1
Brugia malayi hypothetical protein 0.002 0.0065 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.849 1
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.002 0.0024
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0148 0.4005 0.7418
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0034 0.0484 0.1206
Loa Loa (eye worm) hypothetical protein 0.0034 0.0484 0.057
Echinococcus granulosus tar DNA binding protein 0.0138 0.3683 0.3683
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0484 0.0569
Brugia malayi TAR-binding protein 0.0138 0.3683 0.4337
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0034 0.0484 0.0484
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0034 0.0484 0.1206
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0182 0.0182
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0148 0.4005 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0001 0.0001
Entamoeba histolytica rodhanase-like domain containing protein 0.0115 0.2987 0.7458
Loa Loa (eye worm) hypothetical protein 0.0034 0.0484 0.057
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0212 0.0527
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0148 0.4005 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0212 0.0527
Loa Loa (eye worm) transcription factor SMAD2 0.0262 0.7521 0.8858
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.5376 0.6332
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0148 0.4005 0.4717
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0484 0.1204
Echinococcus granulosus chromobox protein 1 0.0075 0.1742 0.1742
Entamoeba histolytica rodhanase-like domain containing protein 0.0115 0.2987 0.7458
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.2438 0.6087
Entamoeba histolytica rodhanase-like domain containing protein 0.0115 0.2987 0.7458
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.1114 0.1312
Leishmania major eukaryotic initiation factor 4a, putative 0.0148 0.4005 1
Echinococcus granulosus zinc phosphodiesterase 0.0034 0.0484 0.0484
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0034 0.0484 0.0484
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.849 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0034 0.0484 0.0569
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.5376 0.6332
Schistosoma mansoni zinc finger protein 0.0021 0.0084 0.0154
Entamoeba histolytica metallo-beta-lactamase family protein 0.0034 0.0484 0.1206
Schistosoma mansoni hypothetical protein 0.002 0.0065 0.0119
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0237 0.059
Onchocerca volvulus 0.0034 0.0484 0.0788
Echinococcus granulosus geminin 0.0168 0.4621 0.4621
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0034 0.0484 0.0569
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0001 0.0001
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0148 0.4005 0.4005
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0484 0.1206
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0115 0.2987 0.3518
Entamoeba histolytica metallo-beta-lactamase family protein 0.0034 0.0484 0.1206
Mycobacterium tuberculosis Possible hydrolase 0.0034 0.0484 0.1204
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0237 0.0278
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0034 0.0484 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0484 0.1204
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0076
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0115 0.2987 0.3518

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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