Detailed information for compound 1434530

Basic information

Technical information
  • TDR Targets ID: 1434530
  • Name: N-(2,3-dimethylcyclohexyl)-2-(4-oxo-5-propylp yridazino[5,4-b]indol-3-yl)acetamide
  • MW: 394.51 | Formula: C23H30N4O2
  • H donors: 1 H acceptors: 2 LogP: 4.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c2ccccc2c2c1c(=O)n(nc2)CC(=O)NC1CCCC(C1C)C
  • InChi: 1S/C23H30N4O2/c1-4-12-26-20-11-6-5-9-17(20)18-13-24-27(23(29)22(18)26)14-21(28)25-19-10-7-8-15(2)16(19)3/h5-6,9,11,13,15-16,19H,4,7-8,10,12,14H2,1-3H3,(H,25,28)
  • InChiKey: JOTMUDXRYXKKEY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,3-dimethylcyclohexyl)-2-(4-oxo-5-propyl-pyridazino[5,4-b]indol-3-yl)acetamide
  • N-(2,3-dimethylcyclohexyl)-2-(4-oxo-5-propyl-3-pyridazino[5,4-b]indolyl)acetamide
  • N-(2,3-dimethylcyclohexyl)-2-(4-keto-5-propyl-pyridazino[5,4-b]indol-3-yl)acetamide
  • N-(2,3-dimethylcyclohexyl)-2-(4-oxo-5-propyl-pyridazino[5,4-b]indol-3-yl)ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0056 0.0184 0.0184
Echinococcus granulosus intermediate filament protein 0.0032 0.007 0.0069
Echinococcus multilocularis tyrosine protein kinase pr2 0.003 0.0063 0.0061
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.007 0.0087
Brugia malayi protein-tyrosine kinase 0.003 0.0063 0.0079
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0119 0.0131
Brugia malayi hypothetical protein 0.003 0.0063 0.0079
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.003 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0032 0.007 0.007
Echinococcus granulosus ephrin type A receptor 4 A 0.003 0.0063 0.0061
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0069 0.0086
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0063 0.0063
Trypanosoma cruzi protein kinase, putative 0.003 0.0063 0.0073
Chlamydia trachomatis sulfate transporter 0.0038 0.0101 0.5
Leishmania major hypothetical protein, conserved 0.003 0.0063 0.0073
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.003 0.0063 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Schistosoma mansoni hypothetical protein 0.0205 0.0884 0.1097
Brugia malayi hypothetical protein 0.003 0.0063 0.0079
Loa Loa (eye worm) hypothetical protein 0.0043 0.0124 0.0124
Mycobacterium ulcerans beta-lactamase 0.0043 0.0124 0.0029
Onchocerca volvulus 0.0043 0.0124 0.051
Schistosoma mansoni serine/threonine RGC 0.003 0.0063 0.0073
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Schistosoma mansoni hypothetical protein 0.0744 0.3424 0.4267
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.003 0.0063 0.0063
Brugia malayi Furin-like cysteine rich region family protein 0.003 0.0063 0.0079
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0063 0.0073
Schistosoma mansoni ephrin receptor 0.003 0.0063 0.0073
Onchocerca volvulus 0.0032 0.007 0.0055
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0089 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0124 0.0074
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0063 0.0061
Schistosoma mansoni tyrosine-protein kinase fps85d 0.003 0.0063 0.0073
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0278 0.1231 0.2127
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.003 0.0063 0.0073
Onchocerca volvulus Putative sulfate transporter 0.0241 0.1055 0.8239
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Plasmodium vivax tyrosine kinase-like protein, putative 0.003 0.0063 0.3471
Echinococcus granulosus activin receptor type 0.003 0.0063 0.0061
Echinococcus multilocularis tyrosine protein kinase 0.003 0.0063 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0124 0.0074
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus multilocularis dual specificity testis specific protein kinase 0.003 0.0063 0.0061
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0744 0.3424 0.4271
Schistosoma mansoni carbonic anhydrase 0.1709 0.7968 0.9938
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Schistosoma mansoni carbonic anhydrase 0.0744 0.3424 0.4267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0184 0.0224
Echinococcus multilocularis transfer RNA-Thr 0.003 0.0063 0.0061
Loa Loa (eye worm) TK/EPH protein kinase 0.003 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus multilocularis tyrosine protein kinase Srms 0.003 0.0063 0.0061
Brugia malayi beta-lactamase 0.0043 0.0124 0.0155
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.003 0.0063 0.0061
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.003 0.0063 0.0061
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0014 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1228 0.2121
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.003 0.0032
Echinococcus granulosus SAM and MBT domain containing protein 0.0044 0.0129 0.0143
Echinococcus granulosus lamin dm0 0.0032 0.007 0.0069
Loa Loa (eye worm) TK/EGFR protein kinase 0.003 0.0063 0.0063
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.003 0.0063 0.0061
Echinococcus multilocularis geminin 0.0205 0.0884 0.1086
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0051 0.0158 0.0179
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0089 0.0094
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.003 0.0063 0.0073
Echinococcus multilocularis carbonic anhydrase 0.0744 0.3424 0.426
Brugia malayi bone morphogenetic protein type 1 receptor 0.003 0.0063 0.0079
Echinococcus granulosus carbonic anhydrase 0.0744 0.3424 0.426
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0014 0.0012
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.0063 0.0061
Loa Loa (eye worm) TK/ABL protein kinase 0.003 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Schistosoma mansoni intermediate filament proteins 0.0032 0.007 0.0081
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Echinococcus granulosus tyrosine protein kinase shark 0.003 0.0063 0.0061
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.0063 0.0061
Schistosoma mansoni carbonic anhydrase-related 0.0744 0.3424 0.4267
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Loa Loa (eye worm) intermediate filament protein 0.0032 0.007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0044 0.0129 0.0155
Schistosoma mansoni lamin 0.0032 0.007 0.0081
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.003 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0035 0.0086 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Echinococcus granulosus integrin linked protein kinase 0.003 0.0063 0.0061
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0063 0.0079
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0018 0.0018
Loa Loa (eye worm) transcription factor SMAD2 0.0111 0.0444 0.0444
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Schistosoma mansoni tyrosine-protein kinase fps85d 0.003 0.0063 0.0073
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.003 0.0063 0.0061
Echinococcus granulosus receptor type guanylyl cyclase 0.003 0.0063 0.0061
Brugia malayi SRC-1 0.003 0.0063 0.0079
Echinococcus granulosus lamin 0.0032 0.007 0.0069
Brugia malayi C-terminal src kinase protein 1 0.003 0.0063 0.0079
Echinococcus granulosus tyrosine protein kinase Src42A 0.003 0.0063 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.1788 0.8341 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.0063 0.0061
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.003 0.0063 0.0061
Toxoplasma gondii protein kinase 0.003 0.0063 0.0096
Plasmodium vivax sulfate transporter, putative 0.0038 0.0101 0.7457
Echinococcus multilocularis integrin linked protein kinase 0.003 0.0063 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Mycobacterium leprae Probable transmembrane transport protein 0.0278 0.1231 0.1411
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Brugia malayi Tyrosine-protein kinase PR2 0.003 0.0063 0.0079
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.0063 0.0061
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Echinococcus multilocularis tyrosine protein kinase Abl 0.003 0.0063 0.0061
Toxoplasma gondii ABC1 family protein 0.0043 0.0124 0.0277
Echinococcus multilocularis FL cytokine receptor 0.003 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0124 0.0149
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.0063 0.0073
Brugia malayi Probable tyrosine-protein kinase kin-31 0.003 0.0063 0.0079
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0063 0.0061
Echinococcus granulosus tyrosine protein kinase Btk29A 0.003 0.0063 0.0061
Schistosoma mansoni protein kinase 0.003 0.0063 0.0073
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.003 0.0063 0.0061
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.003 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus granulosus carbonic anhydrase 0.0744 0.3424 0.426
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0175 0.0745 0.0913
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1549 0.7218 0.9
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.003 0.0063 0.0061
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.007 0.007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0124 0.0124
Onchocerca volvulus 0.0241 0.1055 0.8239
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0252 0.0296
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1719 0.8018 0.8018
Schistosoma mansoni src-type protein tyrosine kinase-related 0.003 0.0063 0.0073
Loa Loa (eye worm) protein kinase domain-containing protein 0.003 0.0063 0.0063
Entamoeba histolytica ankyrin repeat protein 0.003 0.0063 0.0000000089967
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Toxoplasma gondii protein kinase domain-containing protein 0.003 0.0063 0.0096
Onchocerca volvulus 0.0032 0.007 0.0055
Schistosoma mansoni hypothetical protein 0.0205 0.0884 0.1097
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0063 0.0073
Echinococcus multilocularis raf serine:threonine protein kinase 0.003 0.0063 0.0061
Schistosoma mansoni protein kinase 0.003 0.0063 0.0073
Echinococcus multilocularis tyrosine protein kinase Src42A 0.003 0.0063 0.0061
Loa Loa (eye worm) TK/RYK protein kinase 0.003 0.0063 0.0063
Loa Loa (eye worm) TK protein kinase 0.003 0.0063 0.0063
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0051 0.0158 0.0179
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Echinococcus granulosus activated cdc42 kinase 1 0.003 0.0063 0.0061
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.0063 0.0061
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.003 0.0063 0.0096
Onchocerca volvulus 0.0043 0.0124 0.051
Echinococcus multilocularis epidermal growth factor receptor 0.003 0.0063 0.0061
Echinococcus granulosus muscleblind protein 0.018 0.0769 0.0943
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.003 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Loa Loa (eye worm) TK protein kinase 0.003 0.0063 0.0063
Entamoeba histolytica carbonic anhydrase, putative 0.1709 0.7968 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus granulosus tyrosine protein kinase Fps85D 0.003 0.0063 0.0061
Echinococcus granulosus activated cdc42 kinase 1 0.003 0.0063 0.0061
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.003 0.0063 0.0096
Brugia malayi Bromodomain containing protein 0.0089 0.0337 0.042
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.1069 0.4954 0.9283
Echinococcus multilocularis tyrosine kinase 0.003 0.0063 0.0061
Schistosoma mansoni carbonic anhydrase-related 0.0744 0.3424 0.4267
Toxoplasma gondii STE kinase 0.003 0.0063 0.0096
Loa Loa (eye worm) TK/KIN6 protein kinase 0.003 0.0063 0.0063
Schistosoma mansoni protein kinase 0.003 0.0063 0.0073
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus granulosus carbonic anhydrase II 0.1719 0.8018 1
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.003 0.0063 0.0063
Brugia malayi hypothetical protein 0.0023 0.003 0.0038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.0139 0.0173
Loa Loa (eye worm) TK/ROR protein kinase 0.003 0.0063 0.0063
Echinococcus granulosus tyrosine protein kinase Src64B 0.003 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0043 0.0124 0.0124
Brugia malayi PHD-finger family protein 0.0029 0.0058 0.0073
Giardia lamblia Protein 21.1 0.003 0.0063 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.0139 0.0173
Schistosoma mansoni protein kinase 0.003 0.0063 0.0073
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.003 0.0063 0.0061
Schistosoma mansoni protein kinase 0.003 0.0063 0.0073
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0063 0.0079
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Brugia malayi Guanylyl cyclase protein 23 0.003 0.0063 0.0079
Plasmodium falciparum protein kinase, putative 0.003 0.0063 0.0096
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0063 0.0061
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.0063 0.0061
Echinococcus granulosus tyrosine protein kinase Blk 0.003 0.0063 0.0061
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0744 0.3424 0.4271
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.003 0.0063 0.0096
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Echinococcus granulosus protein tyrosine kinase 0.003 0.0063 0.0061
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0038 0.0101 0.012
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus granulosus carbonic anhydrase 0.0744 0.3424 0.426
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1719 0.8018 1
Entamoeba histolytica protein kinase, putative 0.003 0.0063 0.0000000089967
Loa Loa (eye worm) TK/ALK protein kinase 0.003 0.0063 0.0063
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1148 0.5327 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1719 0.8018 1
Loa Loa (eye worm) MBCTL1 0.0051 0.0158 0.0158
Echinococcus granulosus insulin receptor 0.003 0.0063 0.0061
Schistosoma mansoni bromodomain containing protein 0.0075 0.0271 0.0333
Plasmodium falciparum protein kinase, putative 0.003 0.0063 0.0096
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Entamoeba histolytica hypothetical protein 0.0035 0.0086 0.0028
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.003 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0063 0.0073
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0063 0.0061
Brugia malayi hypothetical protein 0.0035 0.0086 0.0107
Echinococcus multilocularis SAM and MBT domain containing protein 0.0044 0.0129 0.0143
Echinococcus multilocularis musashi 0.0032 0.007 0.0069
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1719 0.8018 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0124 0.0155
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus granulosus tyrosine protein kinase Lyn 0.003 0.0063 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Brugia malayi integrin-linked kinase 0.003 0.0063 0.0079
Loa Loa (eye worm) beta-lactamase 0.0043 0.0124 0.0124
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Schistosoma mansoni zinc finger protein 0.0023 0.0029 0.003
Schistosoma mansoni protein kinase 0.003 0.0063 0.0073
Trypanosoma brucei carbonic anhydrase-like protein 0.1719 0.8018 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.003 0.0063 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0063 0.0000000085913
Echinococcus granulosus tyrosine protein kinase Btk29A 0.003 0.0063 0.0061
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0063 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0089 0.0106
Loa Loa (eye worm) TK/FAK protein kinase 0.003 0.0063 0.0063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0124 0.0149
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Loa Loa (eye worm) TK protein kinase 0.003 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0063 0.0061
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.0063 0.0061
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1719 0.8018 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.003 0.0063 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Loa Loa (eye worm) hypothetical protein 0.0051 0.0158 0.0158
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Plasmodium falciparum tyrosine kinase-like protein 0.003 0.0063 0.0096
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0744 0.3424 0.4271
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1267 0.1454
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.003 0.0063 0.0079
Echinococcus granulosus dual specificity testis-specific protein kinase 0.003 0.0063 0.0061
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.003 0.0063 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Brugia malayi Pre-SET motif family protein 0.0251 0.1103 0.1376
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0063 0.0073
Brugia malayi Muscleblind-like protein 0.018 0.0769 0.096
Brugia malayi SH2 domain containing protein 0.003 0.0063 0.0079
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0063 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Loa Loa (eye worm) hypothetical protein 0.0744 0.3424 0.3424
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0056 0.0184 0.0212
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0089 0.0106
Echinococcus granulosus fibroblast growth factor receptor 4 0.003 0.0063 0.0061
Echinococcus granulosus tyrosine kinase 0.003 0.0063 0.0061
Leishmania major carbonic anhydrase-like protein 0.1719 0.8018 1
Entamoeba histolytica hypothetical protein 0.0035 0.0086 0.0028
Brugia malayi mbt repeat family protein 0.0044 0.0129 0.0161
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0063 0.0061
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1709 0.7968 1
Echinococcus granulosus tyrosine kinase 0.003 0.0063 0.0061
Echinococcus multilocularis tyrosine protein kinase shark 0.003 0.0063 0.0061
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0744 0.3424 0.3424
Echinococcus multilocularis epidermal growth factor receptor 0.003 0.0063 0.0061
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.003 0.0063 0.0061
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0045 0.005
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0038 0.0101 0.012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0124 0.0137
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.003 0.0063 0.0061
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0063 0.0061
Onchocerca volvulus 0.0044 0.0129 0.0549
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.0063 0.0061
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.003 0.0063 0.0063
Echinococcus multilocularis muscleblind protein 0.018 0.0769 0.0943
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0063 0.0079
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Leishmania major carbonic anhydrase family protein, putative 0.1709 0.7968 0.9938
Echinococcus multilocularis muscleblind protein 1 0.018 0.0769 0.0943
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.003 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0043 0.0124 0.0124
Loa Loa (eye worm) TK protein kinase 0.003 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Plasmodium falciparum carbonic anhydrase 0.0744 0.3424 1
Schistosoma mansoni tyrosine protein kinase 0.003 0.0063 0.0073
Schistosoma mansoni protein kinase 0.003 0.0063 0.0073
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Echinococcus multilocularis protein tyrosine kinase 0.003 0.0063 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.003 0.0063 0.0000000085913
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.003 0.0063 0.0061
Echinococcus multilocularis protein KINase family member (kin 25) 0.003 0.0063 0.0061
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0032 0.0069 0.0081
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0051 0.0158 0.0197
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.0139 0.0139
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0124 0.0074
Leishmania major protein kinase, putative 0.003 0.0063 0.0073
Loa Loa (eye worm) hypothetical protein 0.0048 0.0146 0.0146
Brugia malayi mbt repeat family protein 0.0044 0.0129 0.0161
Echinococcus granulosus natriuretic peptide receptor 1 0.003 0.0063 0.0061
Entamoeba histolytica protein kinase, putative 0.003 0.0063 0.0000000089967
Loa Loa (eye worm) hypothetical protein 0.0043 0.0124 0.0124
Plasmodium falciparum tyrosine kinase-like protein 0.003 0.0063 0.0096
Brugia malayi beta-lactamase family protein 0.0043 0.0124 0.0155
Brugia malayi Bromodomain containing protein 0.0045 0.0133 0.0165
Echinococcus multilocularis kinase suppressor of Ras 1 0.003 0.0063 0.0061
Loa Loa (eye worm) TK protein kinase 0.003 0.0063 0.0063
Echinococcus multilocularis tyrosine kinase 0.003 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0063 0.0061
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.003 0.0063 0.0061
Brugia malayi Tyrosine-protein kinase abl-1 0.003 0.0063 0.0079
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0124 0.0029
Onchocerca volvulus 0.0043 0.0124 0.051
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.003 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus granulosus tyrosine protein kinase 0.003 0.0063 0.0061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0086 0.0089
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.0063 0.0073
Echinococcus multilocularis tyrosine protein kinase Blk 0.003 0.0063 0.0061
Trichomonas vaginalis TKL family protein kinase 0.003 0.0063 0.0000000085913
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.0063 0.0061
Echinococcus multilocularis polycomb protein SCMH1 0.0044 0.0129 0.0143
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.0063 0.0061
Toxoplasma gondii hypothetical protein 0.0744 0.3424 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0086 0.0101
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0124 0.0074
Echinococcus multilocularis tyrosine protein kinase Fgr 0.003 0.0063 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0744 0.3424 0.3424
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0124 0.0149
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Loa Loa (eye worm) MH2 domain-containing protein 0.0111 0.0444 0.0444
Leishmania major protein kinase, putative 0.003 0.0063 0.0073
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.003 0.0063 0.0073
Schistosoma mansoni protein kinase 0.003 0.0063 0.0073
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.003 0.0063 0.0079
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0038 0.0101 0.0207
Loa Loa (eye worm) TK/ACK protein kinase 0.003 0.0063 0.0063
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.003 0.0063 0.0061
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0119 0.0131
Schistosoma mansoni sex comb on midleg homolog 0.0044 0.0129 0.0155
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1103 0.1103
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0086 0.0089
Mycobacterium ulcerans carbonic anhydrase 0.1788 0.8341 1
Echinococcus multilocularis carbonic anhydrase II 0.1719 0.8018 1
Schistosoma mansoni protein kinase 0.003 0.0063 0.0073
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.003 0.0063 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Schistosoma mansoni carbonic anhydrase-related 0.0744 0.3424 0.4267
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.003 0.0063 0.0061
Brugia malayi MH2 domain containing protein 0.0111 0.0444 0.0554
Echinococcus multilocularis heat shock protein 70 0.003 0.0063 0.0061
Schistosoma mansoni myelin transcription factor 1 myt1 0.0051 0.0158 0.0191
Loa Loa (eye worm) hypothetical protein 0.0044 0.0129 0.0129
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0184 0.0224
Echinococcus granulosus epidermal growth factor receptor 0.003 0.0063 0.0061
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0045 0.0038
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Schistosoma mansoni hypothetical protein 0.0024 0.0034 0.0037
Echinococcus multilocularis protein kinase 0.003 0.0063 0.0061
Echinococcus granulosus protein kinase 0.003 0.0063 0.0061
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.003 0.0063 0.0061
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1719 0.8018 1
Brugia malayi intermediate filament protein 0.0032 0.007 0.0087
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.003 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0043 0.0124 0.0124
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0038 0.0101 0.012
Mycobacterium ulcerans hypothetical protein 0.0043 0.0124 0.0029
Plasmodium vivax SET domain protein, putative 0.0036 0.0089 0.6282
Brugia malayi Pre-SET motif family protein 0.0036 0.0089 0.0112
Trypanosoma brucei Flagellum attachment zone protein 20 0.003 0.0063 0.0073
Brugia malayi Raf kinase 0.003 0.0063 0.0079
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.003 0.0063 0.0061
Echinococcus multilocularis natriuretic peptide receptor 1 0.003 0.0063 0.0061
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0063 0.0073
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0124 0.0149
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0124 0.0029
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Echinococcus granulosus kinase suppressor of Ras 1 0.003 0.0063 0.0061
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1719 0.8018 1
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Onchocerca volvulus 0.003 0.0063 0.000000059071
Trichomonas vaginalis TKL family protein kinase 0.003 0.0063 0.0000000085913
Loa Loa (eye worm) carbonic anhydrase 3 0.1719 0.8018 0.8018
Echinococcus multilocularis ephrin type A receptor 4 A 0.003 0.0063 0.0061
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0063 0.0063
Echinococcus multilocularis histone acetyltransferase MYST2 0.0051 0.0158 0.0179
Trichomonas vaginalis esterase, putative 0.0043 0.0124 0.0074
Leishmania major hypothetical protein, conserved 0.0023 0.003 0.0032
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0083 0.0086
Schistosoma mansoni protein kinase 0.003 0.0063 0.0073
Loa Loa (eye worm) hypothetical protein 0.0032 0.0069 0.0069
Loa Loa (eye worm) TK protein kinase 0.003 0.0063 0.0063
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0175 0.0745 0.0913
Loa Loa (eye worm) TK/DDR protein kinase 0.003 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Echinococcus multilocularis carbonic anhydrase 0.0744 0.3424 0.426
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0067
Onchocerca volvulus 0.0036 0.0089 0.022
Brugia malayi SH2 domain containing protein 0.003 0.0063 0.0079
Loa Loa (eye worm) TK/INSR protein kinase 0.003 0.0063 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0063 0.0073
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0918 0.4245 0.792
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0034 0.0034
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Leishmania major hypothetical protein, conserved 0.0043 0.0124 0.0149
Echinococcus multilocularis c src tyrosine kinase 0.003 0.0063 0.0061
Mycobacterium ulcerans carbonic anhydrase 0.1709 0.7968 0.9547
Loa Loa (eye worm) TK protein kinase 0.003 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.003 0.0063 0.0073
Echinococcus granulosus tyrosine protein kinase pr2 0.003 0.0063 0.0061
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0063 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Echinococcus granulosus polycomb protein SCMH1 0.0044 0.0129 0.0143
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Trypanosoma brucei protein kinase, putative 0.003 0.0063 0.0073
Loa Loa (eye worm) hypothetical protein 0.0045 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0035 0.0086 0.0028
Echinococcus multilocularis lamin 0.0032 0.007 0.0069
Plasmodium falciparum protein kinase, putative 0.003 0.0063 0.0096
Mycobacterium ulcerans lipase LipD 0.0043 0.0124 0.0029
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0124 0.0149
Echinococcus granulosus insulin growth factor 1 receptor beta 0.003 0.0063 0.0061
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0044 0.0129 0.0549
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Brugia malayi beta-lactamase family protein 0.0043 0.0124 0.0155
Loa Loa (eye worm) hypothetical protein 0.0043 0.0124 0.0124
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Schistosoma mansoni lamin 0.0032 0.007 0.0081
Loa Loa (eye worm) TK/KIN16 protein kinase 0.003 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Trypanosoma cruzi protein kinase, putative 0.003 0.0063 0.0073
Echinococcus multilocularis protein kinase 0.003 0.0063 0.0061
Echinococcus granulosus tyrosine kinase 0.003 0.0063 0.0061
Brugia malayi ephrin receptor 1 precursor 0.003 0.0063 0.0079
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.003 0.0063 0.0079
Schistosoma mansoni protein kinase 0.003 0.0063 0.0073
Echinococcus multilocularis tyrosine protein kinase ABL1 0.003 0.0063 0.0061
Echinococcus granulosus raf serine:threonine protein kinase 0.003 0.0063 0.0061
Loa Loa (eye worm) TK protein kinase 0.003 0.0063 0.0063
Plasmodium vivax protein kinase, putative 0.003 0.0063 0.3471
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0045 0.0038
Schistosoma mansoni protein tyrosine kinase 0.003 0.0063 0.0073
Echinococcus multilocularis activated cdc42 kinase 1 0.003 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0063
Echinococcus granulosus tyrosine protein kinase ABL1 0.003 0.0063 0.0061
Loa Loa (eye worm) TK protein kinase 0.003 0.0063 0.0063
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0744 0.3424 0.4271
Echinococcus granulosus histone lysine methyltransferase setb 0.0056 0.0184 0.0212
Echinococcus granulosus geminin 0.0205 0.0884 0.1086
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0035 0.0086 0.0101
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.003 0.0063 0.0061
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0252 0.0296
Loa Loa (eye worm) hypothetical protein 0.0046 0.0139 0.0139
Echinococcus granulosus histone acetyltransferase MYST2 0.0051 0.0158 0.0179
Brugia malayi Probable tyrosine-protein kinase kin-31 0.003 0.0063 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.1788 0.8341 1
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0038 0.0101 0.0207
Loa Loa (eye worm) mbt repeat family protein 0.0044 0.0129 0.0129
Echinococcus multilocularis activin receptor type 0.003 0.0063 0.0061
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.003 0.0063 0.0079
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.0063 0.0061
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0124 0.0137
Loa Loa (eye worm) hypothetical protein 0.005 0.0157 0.0157
Echinococcus granulosus zinc finger protein 0.0023 0.0029 0.0018
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Loa Loa (eye worm) hypothetical protein 0.018 0.0769 0.0769
Onchocerca volvulus 0.0286 0.1267 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.003 0.0063 0.3471
Loa Loa (eye worm) hypothetical protein 0.018 0.0769 0.0769
Loa Loa (eye worm) hypothetical protein 0.0083 0.0313 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0063 0.0073
Schistosoma mansoni hypothetical protein 0.027 0.1193 0.1483
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0124 0.0074
Schistosoma mansoni tyrosine kinase 0.003 0.0063 0.0073
Trichomonas vaginalis TKL family protein kinase 0.003 0.0063 0.0000000085913
Echinococcus granulosus c src tyrosine kinase 0.003 0.0063 0.0061
Loa Loa (eye worm) serine/threonine protein kinase 0.003 0.0063 0.0063
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.003 0.0063 0.0061
Loa Loa (eye worm) TK protein kinase 0.003 0.0063 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0124 1
Giardia lamblia Kinase, NEK 0.003 0.0063 1
Brugia malayi hypothetical protein 0.003 0.0063 0.0079
Echinococcus multilocularis carbonic anhydrase 0.0744 0.3424 0.426
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.003 0.0063 0.0061
Echinococcus multilocularis fibroblast growth factor receptor 4 0.003 0.0063 0.0061
Echinococcus multilocularis insulin receptor 0.003 0.0063 0.0061
Brugia malayi Protein kinase domain containing protein 0.003 0.0063 0.0079
Trypanosoma brucei Pseudokinase, putative 0.003 0.0063 0.0073
Echinococcus multilocularis zinc finger protein 0.0023 0.0029 0.0018
Echinococcus granulosus tyrosine protein kinase Srms 0.003 0.0063 0.0061
Schistosoma mansoni sex comb on midleg homolog 0.0044 0.0129 0.0155
Schistosoma mansoni ephrin receptor 0.003 0.0063 0.0073
Loa Loa (eye worm) SRC-1 0.003 0.0063 0.0063
Loa Loa (eye worm) TK/Met protein kinase 0.003 0.0063 0.0063
Echinococcus multilocularis lamin dm0 0.0032 0.007 0.0069
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0744 0.3424 0.4271
Echinococcus granulosus epidermal growth factor receptor 0.003 0.0063 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.0063 0.0063
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.003 0.0063 0.0061
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.0063 0.0061
Loa Loa (eye worm) TK/CSK protein kinase 0.003 0.0063 0.0063

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0651 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (binding) 5.6234 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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