Detailed information for compound 1439628

Basic information

Technical information
  • TDR Targets ID: 1439628
  • Name: 1-[3-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-y l]piperidin-1-yl]pentan-1-one
  • MW: 343.42 | Formula: C19H25N3O3
  • H donors: 0 H acceptors: 3 LogP: 3.22 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC(=O)N1CCCC(C1)c1onc(n1)c1cccc(c1)OC
  • InChi: 1S/C19H25N3O3/c1-3-4-10-17(23)22-11-6-8-15(13-22)19-20-18(21-25-19)14-7-5-9-16(12-14)24-2/h5,7,9,12,15H,3-4,6,8,10-11,13H2,1-2H3
  • InChiKey: XVWXVDPWHWQQLB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidyl]pentan-1-one
  • 1-[3-[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]pentan-1-one
  • 1-{3-[3-(3-Methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-pentan-1-one
  • ASN 06934835
  • MLS000764857
  • SMR000290462

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0409 0.7334 0.7269
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0035 0.0266 0.0028
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0266 0.0266
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.055 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0104 0.1563 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0297 0.5213 0.5096
Brugia malayi FAT domain containing protein 0.008 0.1117 0.0993
Leishmania major peptidylprolyl isomerase-like protein 0.0056 0.0658 0.0529
Trypanosoma cruzi cytochrome P450, putative 0.0074 0.0991 0.0744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0266 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0137 0.1383
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0035 0.0266 0.0131
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0266 0.0266
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0048 0.0512 0.0252
Leishmania major cytochrome p450-like protein 0.0074 0.0991 0.0865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0328 0.5812 0.571
Toxoplasma gondii FATC domain-containing protein 0.0104 0.1563 0.1835
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0056 0.0658 0.0529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0104 0.1563 0.1446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.5205 0.5088
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0035 0.0266 0.0131
Loa Loa (eye worm) hypothetical protein 0.008 0.1117 0.1117
Trypanosoma brucei cytochrome P450, putative 0.0074 0.0991 0.0744
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0035 0.0266 0.0028
Trichomonas vaginalis immunophilin, putative 0.0056 0.0658 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.5751 0.5647
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0035 0.0266 0.4047
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0561 0.0302
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0035 0.0266 0.0131
Echinococcus granulosus expressed conserved protein 0.0112 0.1709 0.1482
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0035 0.0266 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0184 0.3084 0.2915
Leishmania major phosphatidylinositol 3-kinase, putative 0.0184 0.3084 0.2988
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0137 0.5142
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.188 0.1658
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0035 0.0266 0.0131
Leishmania major phosphatidylinositol 3-kinase, putative 0.0035 0.0266 0.0131
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0735 0.0735
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0035 0.0266 0.0131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0641 0.0384
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0104 0.1563 0.1332
Schistosoma mansoni hypothetical protein 0.0049 0.0526 0.0267
Schistosoma mansoni hypothetical protein 0.0041 0.0374 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0184 0.3084 0.2915
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0104 0.1563 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.055 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0035 0.0266 0.0028
Loa Loa (eye worm) hypothetical protein 0.0116 0.1788 0.1788
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0035 0.0266 0.0028
Loa Loa (eye worm) CYP4Cod1 0.0074 0.0991 0.0991
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0035 0.0266 0.0131
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1845 0.1622
Schistosoma mansoni hypothetical protein 0.008 0.1117 0.0873
Schistosoma mansoni fkbp-rapamycin associated protein 0.0104 0.1563 0.1332
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0266 0.0131
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.2811 0.2614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.5751 0.5647
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0056 0.0658 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1845 0.1732
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0991 0.0991
Loa Loa (eye worm) hypothetical protein 0.0051 0.0561 0.0561
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0641 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.8479 0.8441
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0266 0.4047
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0347 0.0083
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0056 0.0658 0.0403
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0056 0.0658 0.0658
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0056 0.0658 0.0403
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.055 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0184 0.3084 0.2895
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0056 0.0658 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0437 0.7871 0.7819
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0056 0.0658 0.0403
Entamoeba histolytica protein kinase rad3, putative 0.0104 0.1563 0.1446
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0266 0.0266
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.008 0.1117 0.0873
Trichomonas vaginalis PIKK family atypical protein kinase 0.0409 0.7334 0.7269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0297 0.5213 0.5096
Loa Loa (eye worm) hypothetical protein 0.0119 0.1845 0.1845
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0056 0.0658 0.043
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0035 0.0266 0.0028
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0035 0.0266 0.0028
Loa Loa (eye worm) phosphatidylinositol kinase 0.0035 0.0266 0.0266
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0266 0.0131
Trypanosoma cruzi cytochrome P450, putative 0.0074 0.0991 0.0744
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.008 0.1117 0.0873
Trichomonas vaginalis PIKK family atypical protein kinase 0.055 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Echinococcus multilocularis expressed conserved protein 0.0112 0.1709 0.1482
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0284 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0374 0.024
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0184 0.3084 0.2895
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.055 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0056 0.0658 0.0403
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0056 0.0658 0.0403
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0184 0.3084 0.2988
Schistosoma mansoni immunophilin 0.0056 0.0658 0.0403
Loa Loa (eye worm) hypothetical protein 0.0029 0.0137 0.0137
Echinococcus multilocularis protein patched 0.0051 0.0561 0.0302
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0228 0.3917 0.375
Entamoeba histolytica hypothetical protein 0.0035 0.0266 0.0131
Schistosoma mansoni patched 1 0.0051 0.0561 0.0302
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0184 0.3084 0.2895
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0035 0.0266 0.0131
Giardia lamblia GTOR 0.055 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0056 0.0658 0.0529
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0104 0.1563 0.1332
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0561 0.033
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.055 1 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0056 0.0658 0.0403
Loa Loa (eye worm) hypothetical protein 0.0104 0.1563 0.1563
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0184 0.3084 0.2895
Echinococcus multilocularis fk506 binding protein 0.0056 0.0658 0.0403
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0641 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0328 0.5812 0.571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.5205 0.5088
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0438 0.788 0.7822
Leishmania major hypothetical protein, unknown function 0.0035 0.0266 0.0131
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0266 0.0131
Schistosoma mansoni hypothetical protein 0.0049 0.0526 0.0267
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0104 0.1563 0.1446
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0116 0.1788 0.2153
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.055 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0137 0.0137
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0561 0.0302
Loa Loa (eye worm) hypothetical protein 0.006 0.0735 0.0735
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0056 0.0658 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0892 0.0669
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0035 0.0266 0.4047
Trichomonas vaginalis PIKK family atypical protein kinase 0.055 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0137 0.1383
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0137 0.1383
Echinococcus granulosus serine protein kinase ATM 0.0104 0.1563 0.1332
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0035 0.0266 0.0028
Trypanosoma cruzi target of rapamycin kinase 3 0.0438 0.788 0.7822
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0284 0.0284
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0266 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0409 0.7334 0.7269
Loa Loa (eye worm) FKBP5 protein 0.0056 0.0658 0.0658
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0035 0.0266 0.4047
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0074 0.0991 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0137 0.0137
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0266 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.1563 0.1357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0437 0.7871 0.7819
Loa Loa (eye worm) hypothetical protein 0.0048 0.0512 0.0512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.1563 0.1357
Schistosoma mansoni hypothetical protein 0.0049 0.0526 0.0267
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0438 0.788 0.785
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0056 0.0658 0.6646
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0137 0.1383
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0266 0.0131
Leishmania major phosphatidylinositol 4-kinase, putative 0.0035 0.0266 0.0131
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0056 0.0658 0.0529
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.055 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.0658 0.0403
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0035 0.0266 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0328 0.5812 0.571
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0184 0.3084 0.2895
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0137 0.5142
Leishmania major hypothetical protein, conserved 0.0035 0.0266 0.0131
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0035 0.0266 0.4047
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.055 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0069 0.0892 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0184 0.3084 0.2915
Trichomonas vaginalis fk506-binding protein, putative 0.0056 0.0658 0.043
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0137 0.1383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0266 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0184 0.3084 0.2915
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0735 0.0606
Loa Loa (eye worm) phosphatidylinositol 3 0.0184 0.3084 0.3084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0641 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0437 0.7871 0.7819
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0184 0.3084 0.2988
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0035 0.0266 0.0028
Schistosoma mansoni immunophilin 0.0056 0.0658 0.0403
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0035 0.0266 0.0131
Brugia malayi CHE-14 protein 0.0051 0.0561 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0357 0.635 0.626
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0056 0.0658 0.0529
Onchocerca volvulus 0.0035 0.0266 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.055 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0035 0.0266 0.0028
Loa Loa (eye worm) phosphatidylinositol 3 0.055 1 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.0697 0.0443
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0184 0.3084 0.2895
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0035 0.0266 0.0131
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0035 0.0266 0.0131
Loa Loa (eye worm) hypothetical protein 0.0032 0.0193 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0892 0.0669
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.026 0.4516 0.4366
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0056 0.0658 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0437 0.7871 0.7819
Leishmania major fk506-binding protein 1-like protein 0.0056 0.0658 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0297 0.5213 0.5096
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0137 0.1383
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0184 0.3084 0.2895
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0104 0.1563 0.1332
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0266 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0056 0.0658 0.043
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.055 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0641 0.0511
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.0658 0.0403
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0561 0.0302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0641 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.1788 0.1587
Trichomonas vaginalis conserved hypothetical protein 0.008 0.1117 0.0899
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0056 0.0658 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0409 0.7334 0.7269
Echinococcus multilocularis serine protein kinase ATM 0.0104 0.1563 0.1332
Loa Loa (eye worm) hypothetical protein 0.0062 0.0778 0.0778
Entamoeba histolytica hypothetical protein 0.0035 0.0266 0.0131
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0735 0.0606
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0035 0.0266 0.0028
Loa Loa (eye worm) hypothetical protein 0.0112 0.1715 0.1715
Loa Loa (eye worm) hypothetical protein 0.0041 0.0374 0.0374
Plasmodium vivax hypothetical protein 0.0035 0.0266 0.4047
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0347 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0437 0.7871 0.7819
Trichomonas vaginalis PIKK family atypical protein kinase 0.0297 0.5213 0.5096
Schistosoma mansoni hypothetical protein 0.0049 0.0526 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0296 0.5205 0.5088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.1563 0.1357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0184 0.3084 0.2915
Entamoeba histolytica hypothetical protein 0.0035 0.0266 0.0131
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0641 0.0384
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1845 0.1622
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0104 0.1563 0.1332
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0035 0.0266 0.4047
Loa Loa (eye worm) hypothetical protein 0.0069 0.0892 0.0892
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0035 0.0266 0.4047
Entamoeba histolytica hypothetical protein 0.0035 0.0266 0.0131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0641 0.0384
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0641 0.0384
Toxoplasma gondii target of rapamycin (TOR), putative 0.0409 0.7334 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0056 0.0658 0.0403
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0056 0.0658 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0284 0.0149
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0048 0.0512 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0409 0.7334 0.7269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0409 0.7334 0.7269
Mycobacterium ulcerans hypothetical protein 0.0029 0.0137 0.1383
Onchocerca volvulus 0.0035 0.0266 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.055 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.2811 0.2614
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0266 0.0131
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0991 0.0991
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0035 0.0266 0.4047
Leishmania major phosphatidylinositol kinase related protein, putative 0.0035 0.0266 0.0131
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0137 0.1383
Brugia malayi Cytochrome P450 family protein 0.0074 0.0991 0.0865
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0035 0.0266 0.0266
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.055 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0035 0.0266 0.0028
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0561 0.0561
Brugia malayi Cytochrome P450 family protein 0.0074 0.0991 0.0865
Schistosoma mansoni immunophilin 0.0048 0.0512 0.0252
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1845 0.1732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147 0.2387 0.2201
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0284 0.0018
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0104 0.1563 0.1446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0409 0.7334 0.7269
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0266 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.6574 0.6491
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0266 0.0131
Entamoeba histolytica hypothetical protein 0.0104 0.1563 0.1446
Leishmania major phosphatidylinositol kinase, putative 0.0035 0.0266 0.0131

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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